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Retrospective review of maternal HIV viral load electronic gatekeeping codes in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2024-02-20 Siphesihle K Mahanjana, Tladi Ledibane, Gayle G Sherman, Tanya Y Murray, Ahmad F Haeri Mazanderani
Maternal electronic gatekeeping (eGK) codes for HIV viral load (VL) testing of pregnant and breastfeeding women were developed to permit increased frequency of maternal HIV VL testing without automated gatekeeping cancellation, and to enable virological surveillance.
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Outcomes and characteristics of patients on protease inhibitors at a tertiary level antiretroviral clinic. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-12-21 Michele Perks, Denasha L Reddy, Francois Venter
Protease inhibitors (PIs) have been recommended as World Health Organization second-line antiretroviral therapy (ART) for low- to middle-income countries for two decades. As dolutegravir-based regimens have become widely available, the future role of PIs is uncertain.
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Confronting the human papillomavirus-HIV intersection: Cervical cytology implications for Kenyan women living with HIV. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-10-27 James M Kangethe,Stephen Gichuhi,Eddy Odari,Jillian Pintye,Kenneth Mutai,Leila Abdullahi,Alex Maiyo,Marianne W Mureithi
Background High-risk human papillomavirus (HR-HPV) is the primary cause of cervical cancer, leading to over 311 000 global deaths, mainly in low- and middle-income countries. Kenyan women living with HIV (WLHIV) face a disproportionate burden of HR-HPV. Objectives We determined the prevalence of HR-HPV infections and their association with cervical cytology findings among Kenyan WLHIV. Method We conducted
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Thrombotic thrombocytopaenic purpura in the era of HIV: A single-centre experience. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-10-27 Yusuf Moola,Zaheera Cassimjee,Chandni Dayal,Sheetal Chiba,Adekunle Ajayi,Malcolm Davies
Background Thrombotic thrombocytopaenia purpura (TTP) is a rare disorder which carries a high mortality. HIV is an important cause of TTP. Objectives We assessed the presentation and response to plasma exchange (PEX) by HIV status. Method A single-centre retrospective review of all patients receiving PEX for TTP between 01 January 2010 and 31 December 2019 was undertaken. Demographics and presenting
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No increased in utero and peripartum HIV acquisition risk in HIV-exposed preterm infants. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-10-19 Gbolahan Ajibola,Charlotte Mdluli,Kara Bennett,Maureen Sakoi,Oganne Batlang,Joseph Makhema,Shahin Lockman,Roger Shapiro,Landon Myer,Kathleen Powis
Background Limited data exist on the differential risk of HIV acquisition between infants born preterm versus those born at term to women living with HIV (WLHIV). With a reported increase in preterm delivery among pregnant WLHIV, understanding the risk of vertical transmission of HIV in preterm infants can inform strategies to optimise the timing of diagnostic testing, antiretroviral prophylaxis, and
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2023 Southern African HIV Clinicians Society Adult Antiretroviral Therapy Guidelines: What's new? South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-09-29 Jeremy Nel,Camilla Wattrus,Regina Osih,Graeme Meintjes
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Southern African HIV Clinicians Society 2023 Guideline for post-exposure prophylaxis: Updated recommendations. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-09-28 Jaco Horak,Willem D F Venter,Camilla Wattrus,Nectarios Papavarnavas,Pauline Howell,Gillian Sorour,Carole Wallis,Katherine Gill,Francesca Conradie,Linda-Gail Bekker
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Doxycycline post-exposure prophylaxis for sexually transmitted infections in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-09-28 Remco P H Peters, James A McIntyre, Nigel Garrett, Adrian J Brink, Connie L Celum, Linda-Gail Bekker
South Africa has a large burden of bacterial sexually transmitted infections (STIs) with high rates among men who have sex with men (MSM). Randomised controlled trials have recently demonstrated high effectiveness of doxycycline post-exposure prophylaxis (PEP) for prevention of bacterial STIs in MSM, with 70% - 85% reductions in Chlamydia trachomatis infection and syphilis, and approximately 50% reduction
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Diminished health and social outcomes among men who have sex with men who use drugs in Zimbabwe. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-09-27 Munyaradzi Mapingure,Innocent Chingombe,Tafadzwa Dzinamarira,Chesterfield Samba,Brian Moyo,Owen Mugurungi,Godfrey Musuka
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The prevalence of multimorbidity in virally suppressed HIV-positive patients in Limpopo. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-09-18 Limakatso Lebina, Tumiso Malatji, Firdaus Nabeemeeah, Kegaugetswe Motsomi, Tsundzukani Siwelana, Khuthadzo Hlongwane, Neil Martinson
Non-communicable diseases (NCDs) are an emerging global public health problem.
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Outcomes of a model for re-testing HIV-negative index contacts in Sedibeng, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-05-29 Ditebogo L Phiri,Kate Rees,Natasha Davies
Background Index contact testing is an HIV case-finding approach that elicits sexual or needle-sharing partners, as well as biological children, of people living with HIV (PLHIV) and offers them HIV testing services. Objectives We aim to describe the results of an innovative project in Sedibeng District that expanded index testing by retesting previously negative contacts and incorporating status-neutral
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An audit of adherence to cervical cancer screening guidelines in a tertiary-level HIV clinic. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-05-26 Jeffrey Bolon,Amy Samson,Natalie Irwin,Lyle Murray,Langanani Mbodi,Sarah Stacey,Nicholas Aikman,Louell Moonsamy,Jarrod Zamparini
Background Cervical cancer is the most common malignancy affecting South African women aged 15-44 years, with a higher prevalence among women living with HIV (WLWH). Despite recommendations for a screening target of 70%, the reported rate of cervical cancer screening in South Africa is 19.3%. Objectives To investigate the adherence of healthcare workers to cervical cancer screening guidelines in a
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Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-05-23 Sibongiseni Malinga,Aabida Khan,Moherndran Archary
We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching
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Weight gain on dolutegravir: Association is not the same as causation. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-05-15 Gary Maartens,Phumla Sinxadi,W D Francois Venter
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Survival outcomes of HIV-positive adults on peritoneal dialysis at Helen Joseph renal unit. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-05-10 Kagisho L Thomas,Malcolm Davies
Background HIV is a risk factor for the development of chronic kidney disease. People with chronic kidney disease in the state sector are likely to be prescribed continuous ambulatory peritoneal dialysis (CAPD). Previous studies have raised concern about the safety of CAPD in people living with HIV (PLWH) compared to HIV-negative patients. Objectives To compare the risk of peritonitis, and modality
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Effect of HIV on mortality among hospitalised patients in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-04-26 Dirk J Lamprecht,Neil Martinson,Ebrahim Variava
Background HIV and AIDS continues to impose substantial healthcare challenges in sub-Saharan Africa, but there are limited local data comparing inpatient outcomes between people with HIV (PLWH) and those uninfected. Objectives To compare cause-specific mortality among hospitalised adolescents and adults, stratified by HIV-serostatus. Method A cross-sectional analysis was performed, analysing cause-specific
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The prevalence of cervical abnormalities: Comparison of youth with perinatally acquired HIV and older women in Botswana. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-03-28 Thabo Phologolo,Mogomotsi Matshaba,Bathusi Mathuba,Keboletse Mokete,Ontibile Tshume,Elizabeth Lowenthal
Background Cervical cancer burden and prevalence of precursor lesions is unknown among young women living with HIV in high prevalence settings. Current cervical cancer screening guidelines in resource-limited settings with high HIV prevalence typically exclude adolescents and young women. After observing two cases of advanced cervical cancer among young women with perinatally acquired HIV, a pilot
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COVID-19 severity and in-hospital mortality in an area with high HIV prevalence. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-01-27 Michael T Boswell,Tshegofatso Maimela,Dan Hameiri-Bowen,George Riley,Albertus Malan,Nickietta Steyn,Nomonde Nolutshungu,Talita R de Villiers,Zelda de Beer,John Mathabathe,Khanyisile Tshabalala,Fareed Abdullah,Rajiev Ramlall,Marthinus Heystek,Debashis Basu,Paul Rheeder,Veronica Ueckermann,Wesley van Hougenhouck-Tulleken
Background HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. Objectives We investigated the associations among clinical phenotypes, laboratory biomarkers, and hospitalisation outcomes in a cohort of people hospitalised with COVID-19 in a high HIV prevalence area. Method We conducted a prospective observational
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Human rights violations among men who have sex with men and transgender people in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-01-23 Raymond Chimatira,Dumo Jebese-Mfenqe,Joram Chikwanda,Edward Sibanda,Qhawekazi Thengwa,Bulumko Futshane,Sisanda Gaga
Background Men who have sex with men (MSM) and transgender (TG) people face human rights violations (HRVs) which impact their access to critical interventions for HIV prevention, treatment, and related services. Objectives This study describes how Beyond Zero, a not-for-profit organisation in South Africa, built an HRV reporting system and discusses data on the HRVs experienced by MSM and TG people
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Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2023-01-12 Lyneshree Munsami,Clara M Schutte,Maryke de Villiers,Juliane Hiesgen
Background The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. Data regarding this condition are limited. Objectives We describe the clinical picture of late-onset efavirenz toxicity, investigate co-morbidities and report outcomes. Method This
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Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-12-13 Enkosi Mondleki,Clifford G Banda,Nomathemba C Chandiwana,Simiso Sokhela,Lubbe Wiesner,Francois Venter,Gary Maartens,Phumla Z Sinxadi
Background Dolutegravir, a component of the preferred first-line antiretroviral therapy regimen, has been associated with increased weight gain. South Africa has a high prevalence of obesity, especially among women. Understanding dolutegravir exposure in patients with obesity is important for dose optimisation. Objectives We compared the pharmacokinetic parameters of dolutegravir in Southern African
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Effect of a ward-based outreach team and adherence game on retention and viral load suppression. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-12-07 Sanele Ngcobo,Steve Olorunju,Tshifhiwa Nkwenika,Theresa Rossouw
Background Only 66% of South African people living with HIV (PLWH) are virologically suppressed. Therefore, it is important to develop strategies to improve outcomes. Objectives Assess the effect of interventions on 12-month retention in care and virological suppression in participants newly initiated on antiretroviral therapy. Method Fifty-seven clinics were randomised into four arms: Ward-based primary
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COVID-19 and HIV viral load suppression in children and adolescents in Durban, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-12-02 Asandile Mathamo,Kimesh L Naidoo,Jienchi Dorward,Thashir Archary,Christian Bottomley,Moherndran Archary
Background The coronavirus disease 2019 (COVID-19) pandemic poses challenges to paediatric and adolescent HIV treatment programme. Modelling exercises raised concerns over potential impact of disruptions. Objectives To describe the impact of the COVID-19 pandemic on viral load (VL) testing among infants, children and adolescents on antiretroviral treatment (ART) in Durban, South Africa. Method Routinely
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Experiences in receiving financial incentives to access HIV care in Johannesburg, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-11-17 Sara Rachel Schlehr,Leanne Singh,Athini Nyatela,Sizwe Nqakala,Samanta T Lalla-Edward
Background Financial incentivisation has been used to improve all steps of the HIV cascade with varying results. Most studies conducted on the matter are of a quantitative nature, not giving enough space for in-depth understanding as to why financial incentives work or do not work. Objectives To describe experiences with, and opinions on, the use of financial incentives to promote linkage to and retention
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Comparative performance of cardiovascular risk prediction models in people living with HIV. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-11-15 Irtiza S Tahir,Alinda G Vos,Johanna A A Damen,Roos E Barth,Hugo A Tempelman,Diederick E Grobbee,Karine Scheuermaier,Willem D F Venter,Kerstin Klipstein-Grobusch
Background Current cardiovascular risk assessment in people living with HIV is based on general risk assessment tools; however, whether these tools can be applied in sub-Saharan African populations has been questioned. Objectives The study aimed to assess cardiovascular risk classification of common cardiovascular disease (CVD) risk prediction models compared to the Data Collection on Adverse Events
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Incidence of hepatitis C virus infection among people living with HIV: An Egyptian cohort study. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-11-09 Fatma Elrashdy,Suzan Hagag,Rahma Mohamed,Shereen Abdel Alem,Safa Meshaal,Ahmed Cordie,Aisha Elsharkawy,Gamal Esmat
Background Egypt used to have one of the highest hepatitis C virus (HCV) infection prevalence rates worldwide, with an estimated HCV prevalence of around 4.5% to 6.7%. Objectives To determine the HCV infection incidence rate amid Egyptian patients living with HIV. Method A total of 460 HIV-positive patients were recruited in a retrospective cohort study from Imbaba Fever Hospital, Cairo, between January
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Oral pre-exposure prophylaxis uptake, adherence, and adverse events among South African men who have sex with men and transgender women. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-11-08 Linda-Gail Bekker,Danielle Giovenco,Stefan Baral,Karen Dominguez,Rachel Valencia,Travis Sanchez,A D McNaghten,Ryan Zahn,Clarence S Yah,Zinhle Sokhela,Richard Kaplan,Refliwe N Phaswana-Mafuya,Chris Beyrer,Patrick S Sullivan
Background HIV prevention programmes that include pre-exposure prophylaxis (PrEP) for men who have sex with men (MSM) and transgender women (TGW) in South Africa have not been widely implemented. Objectives The authors examined oral PrEP uptake, adherence, and adverse events among HIV-uninfected MSM and TGW to inform intervention acceptability and feasibility. Method In 2015, MSM and TGW in two South
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Weight gain in children from birth to 10 years on antiretroviral treatment. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-10-28 Janine Scholtz,Susanna M Ellis,Herculina S Kruger
Background Inadequate weight gain could indicate clinical deterioration in infants and children living with HIV (CLHIV). The World Health Organization's (WHO) weight-for-age z-score (WAZ) growth standards and reference charts are currently used in South Africa to assess weight gain in CLHIV on antiretroviral treatment (ART). Objectives To assess weight gain patterns of infants and children initiated
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HIV viral load suppression before and after COVID-19 in Kinshasa and Haut Katanga, Democratic Republic of the Congo. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-10-28 Gulzar H Shah,Gina D Etheredge,Stacy W Smallwood,Lievain Maluantesa,Kristie C Waterfield,Osaremhen Ikhile,John Ditekemena,Elodie Engetele,Elizabeth Ayangunna,Astrid Mulenga,Bernard Bossiky
Background The coronavirus disease 2019 (COVID-19) pandemic resulted in unique programmatic opportunities to test hypotheses related to the initiation of antiretroviral treatment (ART) and viral load (VL) suppression during a global health crisis, which would not otherwise have been possible. Objectives To generate practice-relevant evidence on the impact of initiating ART pre-COVID-19 versus during
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Emergent dolutegravir resistance in integrase-naïve, treatment experienced patients from Zimbabwe. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-10-26 Linda A Mandikiyana Chirimuta,Margaret J Pascoe,Sara Lowe
We report two cases of dolutegravir (DTG) resistance in highly treatment experienced patients. Monitoring for treatment failure and adherence support is important in highly treatment experienced patients taking DTG. What this study adds Dolutegravir is the mainstay of HIV treatment programmes and emergence of drug resistance to DTG is of public health relevance.
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Delays in third-line antiretroviral therapy and outcomes in North West province. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-10-24 Babalwa Majova,Ebrahim Variava,Neil Martinson
Background Rapid switching from second-line to third-line antiretroviral therapy (TLART) is crucial for achieving viral suppression and reducing illness related to ART failure. Objectives This retrospective cohort study quantified the waiting periods for TLART initiation after virological failure on second-line therapy was detected, assessed factors associated with delays and assessed the outcomes
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Low-level viraemia despite emergence of dolutegravir-resistant variants. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-30 Johannes C Botha,Kim Steegen,Mariam Edoo,Jeremy Nel,Gert U van Zyl
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Rifampicin resistance and mortality in patients hospitalised with HIV-associated tuberculosis. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-27 Ruan Spies,Charlotte Schutz,Amy Ward,Avuyonke Balfour,Muki Shey,Mark Nicol,Rosie Burton,Bianca Sossen,Robert Wilkinson,David Barr,Graeme Meintjes
Background Patients with HIV and drug-resistant tuberculosis (TB) are at high risk of death. Objectives We investigated the association between rifampicin-resistant TB (RR-TB) and mortality in a cohort of patients who were admitted to hospital at the time of TB diagnosis. Method Adults hospitalised at Khayelitsha Hospital and diagnosed with HIV-associated TB during admission, were enrolled between
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Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-27 Remco P H Peters,Nigel Garrett,Nomathemba Chandiwana,Ranmini Kularatne,Adrian J Brink,Karen Cohen,Katherine Gill,Thato Chidarikire,Camilla Wattrus,Jeremy S Nel,Mahomed Y S Moosa,Linda-Gail Bekker
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The sexual and reproductive health needs of young people living with HIV in Gauteng, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-06 Bandile E Ndlazi,Thembekile Masango
Background HIV has been the focus of health systems strengthening in South Africa for the past two decades. Despite progress, sexual and reproductive health (SRH) challenges such as contraception, condom usage and HIV disclosure of young people living with HIV (YPLHIV) remain inadequately addressed. Therefore, the purpose of the study was to describe the SRH needs of YPLHIV and make recommendations
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Dolutegravir for second-line treatment: Programmatic implications of new evidence. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-05 Ying Zhao,Gary Maartens,Graeme Meintjes
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Ethically acceptable consent approaches to adolescent research in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-09-05 Marian Loveday,Ameena Goga,Ames Dhai,Melodie Labuschaigne,Theresa Roussouw,Theresa Burgess,Ann Strode,Melissa Wallace,Marc Blockman,Brodie Daniels,Elizabeth Spooner,Linda-Gail Bekker
Background Adolescents are a unique population with significant unmet health needs. They are often excluded from research that may benefit them as they are perceived as vulnerable and needing protection from research participation. For Research Ethics Committees, conflicting positions in statutes, regulations and ethical guidelines about who provides informed consent for adolescent involvement in health
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COVID-19 vaccine acceptance and associated factors among people living with HIV in the Middle East and North Africa region. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-08-24 Rahma Mohamed, Trenton M White, Jeffrey V Lazarus, Amany Salem, Reham Kaki, Wafa Marrakchi, Sara G M Kheir, Ibrahim Amer, Fida M Ahmed, Maie A Khayat, Nabeela Al-Abdullah, Batool Ali, Roaa Sultan, Bandar Alamri, Anouf Abdulmajid, Ikbal Kooli, Mohamed Chakroun, Tariq A Madani, Gamal Esmat, Ahmed Cordie
Identifying coronavirus disease 2019 (COVID-19) vaccine acceptance and associated factors among people living with HIV (PLHIV) in the Middle East and North Africa region is important to meet the need for broad-scale vaccination against COVID-19.
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Cutaneous squamous cell carcinoma in vertically acquired HIV and epidermodysplasia verruciformis. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-06-27 Linda A Mandikiyana Chirimuta, Francis J Ndowa, Margaret J Pascoe
Acquired epidermodysplasia verruciformis (EV) is a skin disorder that has been described in individuals with perinatally acquired HIV. Many cases have been identified in sub-Saharan Africa in keeping with the epidemiology of HIV infection compared to the rest of the world, where cases are rare. Epidermodysplasia verruciformis skin lesions may undergo malignant transformation. There are few documented
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Rechallenge after anti-tuberculosis drug-induced liver injury in a high HIV prevalence cohort. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-06-14 Muhammed Shiraz Moosa, Gary Maartens, Hannah Gunter, Shaazia Allie, Mohamed F Chughlay, Mashiko Setshedi, Sean Wasserman, David F Stead, Karen Cohen
There are limited data on the outcomes of rechallenge with anti-tuberculosis therapy (ATT) following anti-tuberculosis drug-induced liver injury (AT-DILI) in a high HIV prevalence setting.
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Digitally supported HIV self-testing increases facility-based HIV testing capacity in Ekurhuleni, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-06-13 Nolundi T Mshweshwe-Pakela, Tonderai Mabuto, Luke Shankland, Alex Fischer, Dikeledi Tsukudu, Christopher J Hoffmann
HIV testing is the first step for linkage to HIV prevention or treatment services. Facility-based HIV testing is the most utilised method, but faces challenges such as limited work space and human resources. Digitally supported HIV self-testing (HIVST) provided in clinics shifts testing to the client, potentially empowering the client, and addresses such constraints.
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Factors associated with viral suppression among adolescents on antiretroviral therapy in Free State province, South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-06-13 Balsam A Y Elashi, Brian E van Wyk
In 2019, about 1.7 million adolescents between the ages of 10 and 19 years were living with HIV worldwide, of which 170 000 were newly infected with HIV in 2019. South Africa has the highest number of persons living with HIV. Although there has been major improvement in access to antiretroviral therapy (ART), it is still unclear what proportion of adolescents (aged 10-19 years) are virally suppressed
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Splenic hydatid disease in pregnancy. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-05-26 Kirstie F Thomson, Florence Mahlobo, Denasha L Reddy
Hydatid disease in the South African setting remains an important differential diagnosis in many appropriate clinical presentations, such as splenomegaly. Splenic hydatid disease in pregnancy is a rare and complex disease to manage.
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Corrigendum: The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-05-20 Oda E van den Berg, Erica J Shaddock, Sarah L Stacey, Charles Feldman, Roos E Barth, Diederick E Grobbee, Willem D F Venter, Kerstin Klipstein-Grobusch, Alinda G Vos
[This corrects the article DOI: 10.4102/sajhivmed.v22i1.1312.].
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Tracking adverse drug reactions and medication errors in the Central Chronic Medicine Dispensing and Distribution (CCMDD) programme in South Africa. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-05-19 Kennedy Otwombe, Maggie Munsamy, Mukesh Dheda, Nishana Ramdas, Corlee Herbst, Merlin Pillay, Tanya van Tonder, Celicia Serenata, Samanta Lalla-Edward
The South African Central Chronic Medicine Dispensing and Distribution (CCMDD) programme is a National Health Insurance (NHI) initiative that improves access to medicine for patients.
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Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-29 Grace Karugaba, Gloria Thupayagale-Tshweneagae, Mary M Moleki, Onkabetse V Mabikwa, Mogomotsi Matshaba
Due to the successful antiretroviral therapy (ART) programme in Botswana, large numbers of perinatally HIV-infected adolescents are emerging into young adulthood. Young adulthood is a critical period of human development. However, there is lack of information on the factors affecting the health-related quality of life (HRQOL) of young adults living with perinatally acquired HIV (YALPH) in Botswana
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Utilisation of cervical cancer screening among women living with HIV at Kenya's national referral hospital. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-25 James M Kangethe, Aliza Monroe-Wise, Peter N Muiruri, James G Komu, Kenneth K Mutai, Mirriam M Nzivo, Jillian Pintye
In 2009, Kenyatta National Hospital (KNH) integrated cervical cancer screening within HIV care using visual inspection with acetic acid (VIA) and Pap smear cytology.
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Where are the children? Case finding in 5–14-year-olds living with HIV in Johannesburg South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-14 Jackie L. Dunlop,Carol L. Tait,Moyahabo Mabitsi,Kate Rees
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Understanding patients reinitiating antiretroviral therapy in two South African districts South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-14 Kate Rees,Melanie Bisnauth,Cara O’Connor,Tshifhiwa Ramvhulela,Nomzamo Vali
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Psychosocial support for adolescents and youth living with HIV during COVID-19: A differentiated approach is needed. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-14 Carol L Tait,Njabulo Mbanda,Rudairo Tumba,Marnie J Vujovic,Kate Rees
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Alere Determine-tuberculosis lipoarabinomannan positivity in disseminated non-tuberculous mycobacteria: An illustrative case series. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-04-04 Riana Greyling, Graeme Meintjes, Bianca Sossen
In outpatients, the World Health Organization recommends that the urine Alere Determine-tuberculosis lipoarabinomannan (AlereLAM) should be used to support the diagnosis of tuberculosis (TB) in people living with HIV (PLHIV) with CD4 counts ≤ 100 cells/µL or with signs of being 'seriously ill'. There is a risk of a false-positive AlereLAM in disseminated non-tuberculous mycobacterial (NTM) infections
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Association between socio-economic factors and HIV self-testing knowledge amongst South African women. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-03-24 Michael Ekholuenetale, Chimezie I Nzoputam, Osaretin C Okonji
Self-testing for HIV is an effective and alternative method of increasing HIV testing rates and a strategy for reaching populations that are underserved by HIV testing services. Nonetheless, many resource-constrained settings are yet to adopt HIV self-testing (HIVST) into their national HIV programmes.
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Evaluation of the modified Wells score in predicting venous thromboembolic disease in patients with tuberculosis or HIV in a South African setting. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-03-23 Tweedy Keokgale, Sarah A van Blydenstein, Ishmail S Kalla
There is paucity of data on the modified Wells score (MWS) utility on patients with venous thromboembolism (VTE) in a South African setting where there is a high burden of HIV and tuberculosis (TB). This study analyses the performance of this score in HIV/TB-infected patients compared with non-infected patients.
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Cytomegalovirus retinitis and antiretroviral treatment: A fifteen year experience. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-03-08 Serisha Jay Narain, Linda Visser, Wilbert Sibanda
South Africa's public antiretroviral treatment (ART) programme has undergone progressive changes since its introduction in 2004. The effect of this on the burden of the AIDS-defining opportunistic infection, cytomegalovirus retinitis (CMVR), in SA, has not been fully appreciated.
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Age-related differences in the vascular function and structure of South Africans living with HIV South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-02-24 Anisca Louwrens,Carla M.T. Fourie,Shani Botha-Le Roux,Yolandi Breet
Background: As the life expectancy of people living with the HIV increases because of antiretroviral treatment (ART), their risk for vascular co-morbidities and early vascular ageing (EVA) also increases.Objective: We aimed to investigate whether HIV infection relates to vascular structure and function in black South African adults and whether this relationship is age dependent.Method: This cross-sectional
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Age-related differences in the vascular function and structure of South Africans living with HIV. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-02-24 Anisca Louwrens, Carla M T Fourie, Shani Botha-Le Roux, Yolandi Breet
As the life expectancy of people living with the HIV increases because of antiretroviral treatment (ART), their risk for vascular co-morbidities and early vascular ageing (EVA) also increases.
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The influence of smoking and HIV infection on pulmonary function. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-02-21 Annelotte E Sussenbach, Sjors W L van Gijzel, Samanta T Lalla-Edward, Willem D F Venter, Erica Shaddock, Charles Feldman, Kerstin Klipstein-Grobusch, Alinda G Vos
Prevalence of HIV, smoking, and pulmonary infections in South Africa are high.
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Predictors of low antiretroviral adherence at an urban South African clinic: A mixed-methods study. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-02-10 Connor P Bondarchuk, Nwabisa Mlandu, Tasneem Adams, Elma de Vries
Low adherence to antiretroviral treatment (ART) in people living with HIV (PLHIV) remains a critical issue, especially in vulnerable populations. Although ART is responsible for greatly reducing the mortality and morbidity associated with HIV, low treatment adherence continues to impact the effectiveness of ART. Considering that a high level of adherence to ART is required for the excellent clinical
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Multiple opportunistic infections (pulmonary tuberculosis, Mycobacterium avium complex and parvovirus B19) in a single patient. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-01-25 Midhun T John, Michelle Venter, Jenifer Vaughan, Marianne Black, Daniel Prince, Aishwarya M Luke, Mithra John
HIV infection is a common disease in the South African population. The virus can lead to the development of many opportunistic infections. This case study examines co-infection with three opportunistic infections and the need for clinical suspicion of infections in our HIV population.
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Factors influencing the high rejection rates of HIV 1/2 serology samples at Charlotte Maxeke Johannesburg Academic Hospital and the cost implications. South. Afr. J. Hiv Med. (IF 1.7) Pub Date : 2022-01-11 Bhaveshan Reddy, Naseem Cassim, Florette Treurnicht, Zinhle Makatini
HIV enzyme-linked immunosorbent assay (ELISA) is one of the most requested test sets within Virology and forms an essential part of patient management. Assessment of the rejection criteria is a key quality indicator, crucial for improving laboratory services and efficiency to ensure accurate and reliable results.