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Leishmania major Infection in Synanthropic Rodents: Evidence for the Urbanization of Zoonotic Cutaneous Leishmaniasis (ZCL) in Southern Iran Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-3-7 Saeed Shahabi, Kourosh Azizi, Qasem Asgari, Bahador Sarkari
Cutaneous leishmaniasis is of particular importance in southern Iran. This study aimed to investigate the infection of rodents with Leishmania major in an urban area of Fars Province, located in southern Iran. Rodents were trapped and samples from the liver, spleen, and skin were collected. Impression smears were prepared from these tissues and any skin lesions and were examined microscopically. In
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Relationship between Antibiotic Consumption and Resistance: A Systematic Review Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-3-5 Asrat Agalu Abejew, Gizachew Yismaw Wubetu, Teferi Gedif Fenta
Background. Unreserved use of antibiotics exerted selective pressure on susceptible bacteria, resulting in the survival of resistant strains. Despite this, the relationship between antibiotic resistance (ABR) and antibiotic consumption (ABC) is rarely studied. This systematic review aims to review the relationship between ABC and ABR from 2016 to 2022. Methods. Articles published over 7 years (2016–2022)
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Fulminant Myocarditis with SARS-CoV-2 Infection: A Narrative Review from the Case Studies Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-3-4 Ryohei Ono, Togo Iwahana, Kaoruko Aoki, Hirotoshi Kato, Sho Okada, Yoshio Kobayashi
One of the severe complications of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is myocarditis. However, the characteristics of fulminant myocarditis with SARS-CoV-2 infection are still unclear. We systematically reviewed the previously reported cases of fulminant myocarditis associated with SARS-CoV-2 infection from January 2020 to December 2022, identifying 108 cases
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Isolation and Identification of Effective Probiotics on Drug-Resistant Acinetobacter baumannii Strains and Their Biofilms Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-26 Zahra Abbasi, Seyed Mahdi Ghasemi, Yasaman Ahmadi, Dariush Shokri
Introduction. This study aimed to identify, assess, and isolate strong lactobacilli demonstrating broad antibacterial and anti-biofilm activity against drug-resistant strains of Acinetobacter baumannii. Additionally, the mechanism of inhibition of these organisms was to be determined. Methods. Over a 6-month period (from December 2021 to June 2022), 53 clinical A. baumannii strains were collected from
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Epidemiology and Performances of Typhidot Immunoassay and Widal Slide Agglutination in the Diagnosis of Typhoid Fever in Febrile Patients in Bafoussam City, Cameroon: A Cross-Sectional Comparative Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-22 Aurelie Dahlia Yemeli Piankeu, Siméon Pierre Chegaing Fodouop, Michel Noubom, Emmanuel Boris Gomseu Djoumsie, Georges Ful Kuh, Donatien Gatsing
Background. Enteric fever is a great public health problem associated with significant illness and death in many endemic countries, and its clinical diagnosis is still daunting. The aim of this study was to determine the prevalence and risk factors of S. Typhi among febrile patients in Bafoussam and to evaluate the diagnostic performances of Widal and Typhidot tests. Methods. This was a cross-sectional
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Psychological Status of Medical Staff in Obstetrics and Gynecology Hospitals during the Omicron Pandemic Outbreak in China Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-21 Shuting Bao, Bangwu Chen, Ying Hu, Chee Shin Lee, Qi Wu, Menglin Zhou, Mengkai Du, Shuqi Zhu, Biao Xie, Jiuqiong Hu, Zhaoxia Liang
Background. Medical staff in China faced great challenges and psychological and physiological changes of varying degrees during the omicron epidemic outbreak. It is important to recognize the potential impact of these challenges on the mental health of medical staff and to provide appropriate resources and support to mitigate their effects. Methods. A total of 354 medical staff in two obstetrics and
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Effects of Different SARS-CoV-2 Testing Strategies in the Emergency Department on Length of Stay and Clinical Outcomes: A Randomised Controlled Trial Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-14 Kira Louisa Boldt, Myrto Bolanaki, Fabian Holert, Antje Fischer-Rosinský, Anna Slagman, Martin Möckel
The turn-around-time (TAT) of diagnostic and screening measures such as testing for SARS-CoV-2 can affect a patient’s length of stay (LOS) in the hospital as well as the emergency department (ED). This, in turn, can affect clinical outcomes. Therefore, a reliable and time-efficient SARS-CoV-2 testing strategy is necessary, especially in the ED. In this randomised controlled trial, n = 598 ED patients
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Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-14 Diana Lourdes Padilla-Bórquez, Mónica Guadalupe Matuz-Flores, Jorge Hernández-Bello, Gabriela Athziri Sánchez-Zuno, Samuel García-Arellano, Edith Oregon-Romero, Melva Guadalupe Herrera-Godina, Guillermo González-Estevez, Norma Patricia Adan-Bante, Jesús Alfredo Rosas-Rodríguez, José Francisco Muñoz-Valle
Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control the spread of the disease. Methods. A total of 171 unvaccinated young adults (18–35 years) from Sonora
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Epidemiology of Brucellosis in Small Ruminants of Rural and Peri-Urban Areas of Multan, Pakistan Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-14 Mian Muhammad Awais, Bakhtawar Khadim, Masood Akhtar, Muhammad Irfan Anwar, Gohar Khadim, Abdul Sammad Ali Khan Shirwany, Halil Selcuk Biricik, Abdul Razzaq, Muhammad Sibtain Bhatti
Brucellosis is a widespread zoonotic disease of veterinary and public health importance with considerably higher prevalence in developing/underdeveloped countries. This study reports the prevalence and risk determinants of brucellosis in small ruminants of peri-urban and rural areas of district Multan, Southern Punjab, Pakistan. For this purpose, sera samples (n = 392) of small ruminants were collected
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Frequency and Risk Factors of Surgical Site Infection among Sudanese Patients with Oral Squamous Cell Carcinoma Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-8 Mohamed Elfayeg, Ahmed Suleiman, Yousif Eltohami
Background. In Sudan, patients with oral squamous cell carcinoma (OSCC) presented lately in advanced stages. Surgical site infection (SSI) is one of the most common complications of surgical treatment of OSCC which significantly affects the clinical outcomes. The present study aimed to assess the frequency and risk factors of postoperative surgical site infection among OSCC patients underwent surgery
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Three-Year Point Prevalence Survey of Antimicrobial Use in a Chinese University Hospital Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-8 Fa-Hong Jing, Qiang Wang, Tian-Jiao He, Na Xin, Yao-Wei Wang, Yang Han, Xin Wang, Zhuo Li
To evaluate the prevalence and quality of antimicrobial prescriptions using a Global Point Prevalence Survey (PPS) tool and help identify targets for improvement of antimicrobial prescribing and inform the development of antimicrobial stewardship activities. Antimicrobial prescriptions for inpatients staying at a hospital overnight were surveyed on one weekday in October 2018, November 2019, and November
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Corynebacterium striatum: A True Pathogen in Chronic Contiguous Osteomyelitis Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-2-2 Grishma R. Trivedi, Shehzad S. Merchant
Objective/Purpose. Chronic contiguous osteomyelitis (CCO) is a well-recognized clinical condition. Causative factors include direct trauma, prior surgery, or underlying comorbidities like diabetes and vascular insufficiency. Staphylococci especially S. aureus, Streptococci especially beta-hemolytic Streptococci, Gram-negative bacilli, and anaerobes are the most common pathogens isolated. Corynebacterium
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Molecular Epidemiology of Escherichia coli Resistant to Carbapenems, Fluoroquinolones, and Aminoglycosides Isolated from One of the Largest Hospitals in Vietnam in 2014–2019 Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-31 Tohru Miyoshi-Akiyama, Do Van Thanh, Truong Thai Phuong, Nguyen Quang Huy, Pham Thi Phuong Thuy, Teruo Kirikae, Pham Hong Nhung, Norio Ohmagari
Introduction. Multidrug-resistant (MDR) Gram-negative bacilli including carbapenem-resistant Gram-negative Enterobacteriaceae (CRE) threaten global health. Little is known, however, about the distribution of antimicrobial resistance genes in MDR isolated from patients in Vietnamese hospitals. In this study, we collected MDR Escherichia coli, defined as E. coli resistance against all fluoroquinolones
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The Cell Envelope Integrity Protein Homologue D0Y85_RS06240 of Stenotrophomonas Confers Multiantibiotic Resistance Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-20 Chuanqing Zhong, Xiaoqiang Deng, Aihua Jiang, Yayu Liu, Yuanyuan Liu, Jiafang Fu, Guangxiang Cao
Background. The potential role of cell envelope integrity proteins in mediating antibiotic resistance is not well understood. In this study, we investigated whether the cell envelope integrity protein D0Y85_RS06240 from the multiantibiotic resistant strain Stenotrophomonas sp. G4 mediates antibiotic resistance. Methods. Bioinformatics analysis was conducted to identify proteins related to the D0Y85_RS06240
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Incidence and Predictors of Severe Adverse Drug Reactions among Patients on Antiretroviral Drugs in Harari Regional State, Eastern Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-19 Obsa Anbessa, Behailu Hawulte, Tariku Dingeta, Abdi Birhanu
Background. The introduction of combination antiretroviral therapy improves the quality and longevity of people living with HIV/AIDS. However, adverse drug reactions associated with antiretroviral therapy compromise the resulting benefits and have been reported differently worldwide, including Ethiopia. Severe adverse drug reactions are one of the major public health concerns for the reason that they
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What Makes the Gut-Lung Axis Working? From the Perspective of Microbiota and Traditional Chinese Medicine Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-18 Hui Wang, Ying Wang
Background. An increasing number of studies have proved that gut microbiota is involved in the occurrence and development of various lung diseases and can interact with the diseased lung. The concept of the gut-lung axis (GLA) provides a new idea for the subsequent clinical treatment of lung diseases through human microbiota. This review aims to summarize the microbiota in the lung and gut and the
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Phylogenetic Aspects of Antibiotic Resistance and Biofilm Formation of P. aeruginosa Isolated from Clinical Samples Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-13 Maryam Motevasel, Masoud Haghkhah, Negar Azimzadeh
Introduction. Biofilm production and drug resistance phenomenon play a critical role in P. aeruginosa infections. Several genes, including psl, pel, brlR, and mex, are involved in the phenomenon. The aim of this study was to find the relationship between the mentioned genes and the sources of P. aeruginosa infections. Materials and Methods. Fifty-nine P. aeruginosa isolates detected from clinical specimens
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Prevalence of blaCTX-M and blaTEM Genes in Cefotaxime-Resistant Escherichia coli Recovered from Tertiary Care at Central Nepal: A Descriptive Cross-Sectional Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-8 Rani Kumari Sah, Pragyan Dahal, Ranjana Parajuli, Gorkha Raj Giri, Era Tuladhar
Urinary tract infections (UTIs) are highly prevalent globally, and various antibiotics are employed for their treatment. However, the emergence of drug-resistant uropathogens towards these antibiotics causes a high rate of morbidity and mortality. This study was conducted at the Microbiology Laboratory of Grande International Hospital from November 2021 to May 2022 and aimed to assess the prevalence
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Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2024-1-6 Garima Gautam, Shweta Satija, Ravinder Kaur, Anil Kumar, Divakar Sharma, Megh Singh Dhakad
Intensive care unit (ICU) patients are prone to develop infections by hospital prevalent organisms. The aim of the study was to determine the bacteriological profiles and their drug resistance pattern among different infections in ICU patients of a tertiary care hospital. The record-based retrospective data of culture reports of the patients admitted to all the ICUs of a tertiary care hospital during
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Inpatient Q Fever Frequency Is on the Rise Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-31 Mohamad Alhoda Mohamad Alahmad, Kassem A. Hammoud
Background. Q fever is a zoonotic bacterial infection caused by Coxiella burnetii that is reportable in the USA. This infection is often asymptomatic; acute infection usually manifests as a self-limited febrile illness, hepatitis, or pneumonia. Chronic infection (usually infective endocarditis) often affects patients with valvulopathy or immunosuppression. Herein, we study the inpatient frequency of
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Association between Pneumonia Development and Virulence Gene Expression in Carbapenem-Resistant Acinetobacter baumannii Isolated from Clinical Specimens Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-21 Ji Yun Bae, Ina Yun, Kang Il Jun, Chung-Jong Kim, Miae Lee, Hee Jung Choi
We investigated the virulence gene expression of carbapenem-resistant Acinetobacter baumanii (CRAB) isolated from the respiratory samples of patients with CRAB pneumonia and those with CRAB colonization to identify the virulence genes contributing to CRAB pneumonia’s development and mortality. Patients with CRAB identified from respiratory specimens were screened at a tertiary university hospital between
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Radiology Department: A Potential Source of Multidrug-Resistant Microorganisms: A Cross-Sectional Study at Tertiary Hospital, Palestine Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-18 Zena Odeh, Safaa Abatli, Mohammad Qadi
Introduction. Globally, healthcare facilities face a great challenge in the form of hospital-acquired infections (HAIs). Aside from the morbidity and mortality they cause, these illnesses are also extremely costly. Research on infection transmission in the medical field has been considerable, but not so much in the radiology department. Aim. This study aims to identify the presence of multidrug-resistant
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Time Series Modeling of Tuberculosis Cases in India from 2017 to 2022 Based on the SARIMA-NNAR Hybrid Model Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-16 Baikunth Kumar Yadav, Sunil Kumar Srivastava, Ponnusamy Thillai Arasu, Pranveer Singh
Tuberculosis (TB) is still one of the severe progressive threats in developing countries. There are some limitations to social and economic development among developing nations. The present study forecasts the notified prevalence of TB based on seasonality and trend by applying the SARIMA-NNAR hybrid model. The NIKSHAY database repository provides monthly informed TB cases (2017 to 2022) in India.
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Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-14 Behnam Shafaei, Zahra Nafei, Mehran Karimi, Nasrin Behniafard, Farimah Shamsi, Masoud Faisal, Amir Pasha Amel Shahbaz, Elahe Akbarian
Introduction. The study aims to investigate the characteristics, comorbidities, laboratory findings, and clinical manifestations of under 18-year-old patients who died with the diagnosis of COVID-19 and determination of the most prevalent risk factors. Method. This case-control study was performed at a referral hospital in Yazd from March 2020 to August 2021. All patients under 18 years who were diagnosed
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Knowledge and Attitude toward Antibiotic Use and Identification of Financially Feasible Options to Curb the Spread of Antibiotics in Environment Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-11 Mayank Krishna, Nilesh Makwana, Ganesh S. Kakde, Sapna Puri, Arun S. Kharat
A survey on antibiotic literacy in terms of the use and abuse of antibiotics to track and understand antibiotic consumption is crucial to optimize the use of antibiotics and minimizing antimicrobial resistance (AMR). Purposive random sampling, using the snow-ball questionnaire technique, was adopted to ensure that the respondents distributed across India, coming from rural and urban settings, were
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Anti-Biofilm Effect of Ampicillin-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles Conjugated with Lysostaphin on Methicillin-Resistant Staphylococcus aureus Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-12-6 Elahe Norouzi, Seyed Mostafa Hosseini, Babak Asghari, Reza Mahjoub, Ehsan Nazarzadeh Zare, Mohammad-Ali Shahbazi, Fereshte Kalhori, Mohammad Reza Arabestani
Staphylococcus aureus exhibits the capacity to develop biofilms on various surfaces, encompassing both living and nonliving substrates, enabling it to develop resistance against the immune system and antibiotics. Therefore, this bacterium can cause numerous challenges in healthcare and treatment systems. The present study aimed to investigate the ampicillin-loaded PLGA nanoparticles’ effect on preventing
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Trends and Progress on Antibiotic-Resistant Mycobacterium tuberculosis and Genes in relation to Human Immunodeficiency Virus Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-11-30 N. G. Mbewana Ntshanka, T. A. M. Msagati
Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and tuberculosis (TB) are among the infectious diseases that cause high rates of mortality worldwide. The epidemiology of antibiotic resistance in correlation to people that live with TB and HIV has not been thoroughly investigated particularly in South Africa. Numerous cases of multidrug-resistant TB (MDR-TB) and extensively
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Ready-to-Eat Foods: A Potential Vehicle for the Spread of Coagulase-Positive Staphylococci and Antimicrobial-Resistant Staphylococcus aureus in Buea Municipality, South West Cameroon Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-11-20 Seraphine Nkie Esemu, Sally Tabe Njoh, Lucy Mande Ndip, Nene Kaah Keneh, Jerome Achah Kfusi, Achiangia Patrick Njukeng
The consumption of ready-to-eat (RTE) foods contaminated with coagulase-positive staphylococci (CoPS) and especially Staphylococcus aureus puts consumers at a potential risk of food-borne disease or colonization and subsequent infection. This cross-sectional study determined the levels of CoPS and the presence of S. aureus in RTE foods sold in Buea municipality. A total of 420 RTE food samples, comprising
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Oxygen Requirement and Associated Risk Factors in Post-COVID-19 Patients Admitted to a Tertiary Care Center: A Cross-Sectional Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-11-14 Bishnu Deep Pathak, Binit Upadhaya Regmi, Sushil Joshi, Bishal Dhakal, Suhail Sapkota, Kanchan Bishwakarma, Ashim Bhandari, Seejan Pathak, Shriya Sharma, Aakriti Adhikari, Nabin Simkhada, Dhan Shrestha
Background. COVID-19 commonly affects the lungs and may lead to mild to severe hypoxemia. The supplemental oxygen requirement gradually reduces with the improvement in lung pathology. However, a few patients may have exertional desaturation, and ongoing oxygen needs at the time of hospital discharge. The objective of this research was to study the requirement of oxygen therapy in the immediate post-COVID-19
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Factors Associated with HIV Testing among Male Students Who Have Engaged in Sexual Behaviour in Zhejiang Province, China Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-11-13 Zhongrong Yang, Hui Wang, Qiaoqin Ma, Weiyong Chen, Xiang Zhao, Tingting Jiang, Wanjun Chen, Xin Zhou, Lin Chen
Objective. This study aimed to estimate the prevalence of human immunodeficiency virus (HIV) testing, identify factors associated with HIV testing among male students who have engaged in sexual behaviour in Zhejiang province, and provide a scientific basis for the prevention and control of HIV infection on campus. Methods. Stratified cluster random sampling analysis was performed, which included general
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Antimicrobial-Resistance Profile of Helicobacter pylori, Obtained from Endoscopic Patients in Bahir Dar, North West Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-11-13 Mulat Erkihun, Desalegn Nigatu Chanie, Yesuf Adem Siraj
Background. Antimicrobial resistance for Helicobacter pylori infection is a highly emerging problem throughout the world to treat gastric-associated diseases. People living in developing countries are more likely to acquire a Helicobacter pylori infection and less likely to gate treatment after infection due to poverty. Therefore, the current study was aimed at determining the magnitude and antibiotic-resistance
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Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-10-28 Chinnaperumal Kamaraj, Chinnasamy Ragavendran, Pradisha Prem, Selvam Naveen Kumar, Amir Ali, Abeer Kazmi, Abd Ullah, Rajappan Chandra Satish Kumar, Safir Ullah Khan, Juan Pedro Luna-Arias, Zia-Ur-Rehman Mashwani, Govindhasamy Balasubramani, Saif Ur Rehman
Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace. The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the escalating resistance of parasites to current treatments. This
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Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-10-28 Zhaoyi Pan, Nanping Wu, Changzhong Jin
The intestinal microbiota is an “invisible organ” in the human body, with diverse components and complex interactions. Homeostasis of the intestinal microbiota plays a pivotal role in maintaining the normal physiological process and regulating immune homeostasis. By reviewing more than one hundred related studies concerning HIV infection and intestinal microbiota from 2011 to 2023, we found that human
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Prevalence and Antimicrobial Susceptibility Profile of Salmonella and Shigella among Diarrheic Patients Attending Selected Health Facilities in Addis Ababa, Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-10-14 Tiruneh Ararsa, Deneke Wolde, Haile Alemayehu, Ketema Bizuwork, Tadesse Eguale
Diarrhea is one of the important public health problems in developing countries. Salmonella and Shigella species are the major bacterial causal agents of diarrhea. The increasing burden of antimicrobial resistance is posing difficulty in the treatment of these pathogens. This study aimed to assess the occurrence of Salmonella and Shigella in the feces of diarrheic patients receiving health services
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Prevalence of Candida albicans in High-Risk Human Papillomavirus-Positive Women: A Study in Diyarbakır Province, Turkey Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-10-10 Efdal Oktay Gultekin, Behzat Can
The human papillomavirus (HPV) is a significant public health concern due to its association with the development of cervical cancer. Although inflammation caused by Candida spp. has been shown to facilitate oncogenesis, the interactions between HPV and Candida spp. remain unclear. This study aimed to determine the prevalence and genotype distribution of HR-HPV infection HR-HPV-positiveCandida albicans
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ERC-BiP Functional Protein Pathway for Assessing Endoplasmic Reticulum Stress Induced by SARS-CoV-2 Replication after Cell Invasion Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-10-9 Mingshan Xue, Zhiwei Lin, Teng Zhang, Zhangkai J. Cheng, Runpei Lin, Baojun Guo, Yifeng Zeng, Fengyu Hu, Feng Li, Peiyan Zheng, Huimin Huang, Ning Li, Qi Zhao, Baoqing Sun, Xiaoping Tang
Background. SARS-CoV-2 induces apoptosis and amplifies the immune response by continuously stressing the endoplasmic reticulum (ER) after invading cells. This study aimed to establish a protein-metabolic pathway associated with ER dysfunction based on the invasion mechanism of SARS-CoV-2. Methods. This study included 17 healthy people and 46 COVID-19 patients, including 38 mild patients and 8 severe
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Establishment and Performance Evaluation of Multiplex PCR-Dipstick DNA Chromatography for Mycoplasma pneumoniae and Chlamydia pneumoniae Rapid Detection Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-28 Liuyang Hu, Xiuri Wang, Donglin Cao, Qiuchen Cheng, Qiong Li
Background and Objective. Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) infections are becoming increasingly prominent in respiratory infections. This study established a rapid, simple, sensitive, accurate multiplex PCR-dipstick DNA chromatography assay for Mycoplasma pneumoniae and Chlamydia pneumoniae detection. Methods. Nasopharyngeal swab samples of 300 children with an acute respiratory
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Clinical and Biological Characteristics of Severe Malaria in Children under 5 Years Old in Benin Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-20 Xiao Ma, Xin Fan, Kora Chabi Youssaou, Junfei Zhang, Xingyi Wang, Guoqiang Zheng, Shuping Tian, Yujing Gao
Background. Malaria is a global public health concern, mainly occurring in sub-Saharan Africa. Children infected with malaria are more likely to develop severe disease, which can be fatal. During COVID-19 in 2020, diagnosing and treating malaria became difficult. We analyzed the clinical characteristics and laboratory indicators of children with severe malaria in Benin to provide important information
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Bacterial Profile and Their Antimicrobial Susceptibility Pattern of Isolates Recovered from Intensive Care Unit Environments at Wachemo University Nigist Ellen Mohammed Memorial Comprehensive Specialized Hospital, Southern Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-15 Muluneh Temesgen, Abera Kumalo, Takele Teklu, Getachew Alemu, Desta Odoko
Background. Bacterial contamination of indoor hospitals, especially in intensive care units is a serious health hazard in the world with a high morbidity and mortality rates. Particularly, multidrug-resistant bacteria can cross-contaminate medical devices, inanimate surfaces, health care providers, and patients in the intensive care unit. This study was aimed to assess the bacterial profile and their
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Antimicrobial Therapy as a Risk Factor of Multidrug-Resistant Acinetobacter Infection in COVID-19 Patients Admitted to the Intensive Care Unit Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-14 P. Mihalov, J. Hodosy, A. Koščálová, M. Čaprnda, M. Kachlíková, J. Jurenka, M. Bendžala, P. Sabaka
Background. Multidrug-resistant Acinetobacter (MDR-Ab) is one of the most important pathogens causing superinfections in COVID-19 patients hospitalised in the intensive care unit (ICU). The occurrence of MDR-Ab superinfection significantly impairs the prognosis of patients in the ICU. Overuse of antibiotics in COVID-19 patients might contribute to the risk of developing MDR-Ab infection. Objective
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Association between Probiotics and Modulation of Gut Microbial Community Composition in Colorectal Cancer Animal Models: A Systematic Review (2010–2021) Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-9 Shabnam Zeighamy Alamdary, Shahnaz Halimi, Akram Rezaei, Roghayeh Afifirad
Background. Colorectal cancer (CRC) is one of the most prevalent gastrointestinal malignancies and is considered the third major cause of mortality globally. Probiotics have been shown to protect against the CRC cascade in numerous studies. Aims. The goal of this systematic review was to gather the preclinical studies that examined the impact of probiotics on the alteration of gut microbiota profiles
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Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-9-8 Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni
The Omicron variant of concern (VOC) replaced the delta variant rapidly and became the predominant strain due to more mutations in spike protein and receptor-binding domain (RBD) enhancing its infectivity and binding affinity. The severity of the illness is less than that of the delta variant. Omicron is nonsusceptible to REGEN-COV™ and bamlanivimab with etesevimab. Drugs that are effective against
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Fecal Microbiota Underlying the Coexistence of Schizophrenia and Multiple Sclerosis in Chinese Patients Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-30 Li Shao, Jinlong Fu, Lulu Xie, Guangyong Cai, Yiwen Cheng, Nengneng Zheng, Ping Zeng, Xiumei Yan, Zongxin Ling, Shiwei Ye
Both schizophrenia (SZ) and multiple sclerosis (MS) affect millions of people worldwide and impose a great burden on society. Recent studies indicated that MS elevated the risk of SZ and vice versa, whereas the underlying pathological mechanisms are still obscure. Considering that fecal microbiota played a vital role in regulating brain functions, the fecal microbiota and serum cytokines from 90 SZ
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Isolation and Characterization of Carbapenem-Resistant Escherichia coli Carrying blaNDM and mcr-1 from Recurrent Urinary Tract Infection Patient Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-30 Liang Chen, Jiyong Jian, Zeqiang Xie, Ping Zhao, Man Zhang
Objective. The emergence of carbapenem-resistant E. coli (CRECO), leading to few antibacterial drugs available for CRECO infection. In this study, we report three carbapenem-resistant Escherichia coli (E. coli) isolates coproducing blaNDM and mcr-1 from patients with recurrent urinary tract infection (RUTI). Carbapenem-resistant E. coli strains, E55, E84, and E85, were isolated from the urine sample
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A Sensitive Method for Detecting Beauveria bassiana, an Insecticidal Biocontrol Agent, Population Dynamics, and Stability in Different Substrates Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-25 Zepei Gu, Lijie Chen, Weixing Zhang, Pin Su, Deyong Zhang, Xiaohua Du, Qianze Peng, Zhuoxin Liu, Xiaolan Liao, Yong Liu
Beauveria bassiana is a well-known insecticidal biocontrol agent. Despite its broad field applications, its survival, colonization, and stability under field conditions remained unclear, mainly due to the lack of a quick and reliable detection method. In this study, we developed a quantitative real-time PCR technology to monitor the stability and population dynamics of B. bassiana in different substrates
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Dry Swab-Based Nucleic Acid Extraction vs. Spin Column-Based Nucleic Acid Extraction for COVID-19 RT-PCR Testing: A Comparative Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-23 Mohammed Faraaz Khan, C. Roopa
Conventional nucleic acid extraction involves usage of spin columns to isolate the RNA, but this is labor intensive. This study compares the spin column method with a dry swab-based method of extraction using a proteinase K buffer and subsequent heat inactivation. A total of 56 subjects were tested for COVID-19 by RT-PCR with probes targeting the E and RdRp genes by collecting two nasopharyngeal and
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Antimicrobial Susceptibility Patterns of Shigella Species among Children under Five Years of Age with Diarrhea in Selected Health Centers, Addis Ababa, Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-10 Basha Ayele, Zeleke Mekonnen, Tesfaye Sisay Tessema, Etsehiwot Adamu, Estifanos Tsige, Getenet Beyene
Background. Shigella and parasitic infections are common public health problems throughout the world. Shigellosis is an acute gastroenteritis infection and one of Ethiopia’s most common causes of morbidity and mortality, especially in children under five. High resistance rates to commonly used antibiotic agents have been documented in different locations in Ethiopia. Objective. This study aimed to
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Comparing SARS-CoV-2 Viral Load in Human Saliva to Oropharyngeal Swabs, Nasopharyngeal Swabs, and Sputum: A Systematic Review and Meta-Analysis Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-10 Mouri R. J. Faruque, Floris J. Bikker, Marja L. Laine
A systematic review and meta-analysis were conducted to investigate the SARS-CoV-2 viral load in human saliva and compared it with the loads in oropharyngeal swabs, nasopharyngeal swabs, and sputum. In addition, the salivary viral loads of symptomatic and asymptomatic COVID-19 patients were compared. Searches were conducted using four electronic databases: PubMed, Embase, Scopus, and Web of Science
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Bacterial Colonization in the Airways and Intestines of Twin and Singleton Preterm Neonates: A Single-Center Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-8-1 Jiawei Yao, Tao Ai, Lei Zhang, Wei Tang, Zijin Chen, Yuedong Huang, Yinghong Fan
Limited studies have investigated the microbial colonization of the airways and intestines in preterm neonates. We studied the composition of intestinal and airway bacterial colonies in several preterm twin pairs and singletons to explore the dominant bacteria, assess their variability, and predict their phenotypic and metabolic functions. In this descriptive study, we collected sputum and fetal stool
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Analysis of Antimicrobial Susceptibility in Bacterial Pathogens Associated with Urinary Tract Infections from Beijing Teaching Hospital in China, 2009–2017 Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-7-24 Zeqiang Xie, Jiyong Jian, Liang Chen
Objective. Since a urinary tract infection (UTI) is easy to relapse and difficult to treat, the antibiotic resistance rate has increased year by year in recent years. This study was to analyze the characteristics of the common pathogenic bacteria and the changes of antibiotic resistance in urinary system infection, so as to guide the standard use of antibiotics in a clinical urinary tract infection
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Multidrug-Resistant Pathogens in Burn Wound, Prevention, Diagnosis, and Therapeutic Approaches (Conventional Antimicrobials and Nanoparticles) Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-7-22 Jaber Hemmati, Mehdi Azizi, Babak Asghari, Mohammad Reza Arabestani
Multidrug-resistant pathogens are one of the common causes of death in burn patients and have a high risk of nosocomial infections, especially pneumonia, urinary tract infections, and cellulitis. The role of prolonged hospitalization and empirical antibiotics administration in developing multidrug-resistant pathogens is undeniable. In the early days of admitting burn patients, Gram-positive bacteria
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Development and Validation of a Prediction Model of the Risk of Pneumonia in Patients with SARS-CoV-2 Infection Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-7-18 Xi Yi, Daiyan Fu, Guiliang Wang, Lile Wang, Jirong Li
Objective. To establish a prediction model of pneumonia risk in SARS-CoV-2-infected patients to reduce unnecessary chest CT scans. Materials and Methods. The model was constructed based on a retrospective cohort study. We selected SARS-CoV-2 test-positive patients and collected their clinical data and chest CT images from the outpatient and emergency departments of Hunan Provincial People’s Hospital
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Sero- and Feco-Prevalence of Helicobacter pylori Infection and Its Associated Risk Factors among Adult Dyspeptic Patients Visiting the Outpatient Department of Adet Primary Hospital, Yilmana Densa District, Northwest Ethiopia Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-7-17 Zebasil Mnichil, Endalkachew Nibret, Daniel Mekonnen, Maritu Demelash
Background. Most gastric cancers in the world are attributed to Helicobacter pylori (H. pylori) infections. The prevalence of H. pylori infection is influenced by socioeconomic status, hygiene, and lifestyle of the population. This study aimed to assess sero- and feco-prevalence of H. pylori infections and its associated risk factors among adult dyspeptic patients visiting the outpatient department
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Survival and Mortality in Hospitalized Children with COVID-19: A Referral Center Experience in Yazd, Iran Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-7-17 Farimah Shamsi, Mehran Karimi, Zahra Nafei, Elahe Akbarian
Introduction. COVID-19 prognostic risk factors, therapeutic protocols, and clinical outcomes in pediatric cases are still under investigation. Materials and Methods. This historical cohort study evaluated the survival time of hospitalized children (1 month–18 years old) with COVID-19 admitted from March 2020 to August 2021 to an educational hospital in Yazd, Iran. The follow-up of patients was performed
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Post-COVID-19 Vaccination CNS Magnetic Resonance Imaging Findings: A Systematic Review Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-6-29 Sadegh Ghaderi, Sana Mohammadi, Mehrsa Heidari, Seyedeh Shadi Sharif Jalali, Mahdi Mohammadi
Objective. This systematic review aims to synthesize and analyze the available literature on central nervous system (CNS) magnetic resonance imaging (MRI) findings in individuals who have received COVID-19 vaccinations. Our objective is to enhance understanding of potential neurological side effects, inform clinical practice, and guide future research on the neurological implications of COVID-19 vaccination
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Comparative Diagnostic of Cervical Tuberculous Lymphadenitis: PCR is a Fast, Efficient, and Improved Diagnostic Approach Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-6-13 Himanshu Jha, Chandra Prakash Baveja, Vinay Kamal, Prem Narayan Agarwal, Sonal Saxena, Megh Singh Dhakad, Divakar Sharma
Background and Objectives. Tuberculosis has become a major health problem in India, and the incidence of tuberculous lymphadenitis (TBLN) has increased in parallel with the increase in the incidence of mycobacterial infection worldwide. Therefore, the main objective of this study was to correlate the diagnostic efficacy of polymerase chain reaction (PCR) with various diagnostic techniques in clinically
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Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19 Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-6-5 Seyed Parsa Eftekhar, Mahdi Sepidarkish, Parviz Amri Maleh, Iraj Jafaripour, Mohammad Taghi Hedayati, Kamyar Amin, Roghayeh Pourkia, Saeid Abroutan, Mehrdad Saravi, Farzad Jalali, Mahmoud Sadeghi Haddad Zavareh, Naghmeh Ziaie
Purpose. Maintaining the proper fluid balance is a fundamental step in the management of hospitalized patients. The current study evaluated the impact of negative fluid balance on outcomes of patients with confirmed COVID-19. Methods. We considered the negative fluid balance as a higher output fluid compared to the input fluid. The fluid balance was categorized into four groups (group 4: −850 to −500 ml/day;
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Analyzing Trends in Demographic, Laboratory, Imaging, and Clinical Outcomes of ICU-Hospitalized COVID-19 Patients Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-5-29 Mohsen Gholinataj Jelodar, Shahab Rafieian, Azadeh Allah Dini, Fatemeh Khalaj, Samira Zare, Hanieh Dehghanpour, Samaneh Mirzaei
Background. COVID-19 has led to significant hospitalization and intensive care unit admission rates. The demographic parameters of COVID-19 patients, such as age, underlying illnesses, and clinical symptoms, substantially influence the incidence and mortality of these individuals. The current study examined the clinical and demographic characteristics of COVID-19 intensive care unit (ICU) patients
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A Community-Level Knowledge, Attitude, and Practice about Dengue Fever and the Identification of Mosquito Breeding Containers in Dire Dawa City of Ethiopia: A Cross-Sectional Study Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-5-25 Taye Kebede, Bedasa Tesema, Akalu Mesfin, Dejene Getachew
Background. Lately, dengue fever (DF) is an emerging viral disease, one of the top 10 threats to global health, causing 24 million–130 million symptomatic cases and 10,000–50,000 deaths yearly. DF threat has expanded beyond traditional areas of endemicity, with over 50% of the world population now estimated to live in areas at risk of dengue virus (DV) transmission. Hence, the current study aimed to
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Diagnosis of Acute Dengue Virus Infection Using Enzyme-Linked Immunosorbent Assay and Real-Time PCR Can. J. Infect. Dis. Med. Microbiol. (IF 2.8) Pub Date : 2023-5-22 Gohar Iqbal, Hasnain Javed, Faiz Ahmed Raza, Umar Farooq Gohar, Warda Fatima, Mohsin Khurshid
Dengue fever is a viral infection caused by the dengue virus and is a growing concern for public health worldwide, particularly in tropical and subtropical regions. This study aimed to assess the diagnostic accuracy of a commercially available NS1 ELISA kit for dengue fever in Pakistan using multiplex qRT-PCR as the gold standard. The study recruited 1236 suspected cases of dengue fever admitted to