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Assessment of soil microbial diversity and soil enzyme activities under inorganic input sources on maize and rice ecosystems Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-12 M. Jeya Bharathi, M. Anbarasu, R. Ragu, E. Subramanian
To increase crop productivity, modern agricultural practices comprises fertilizers, algaecides, herbicides and fungicides. The purpose of this study was to evaluate the effects of soil microbial population and soil enzyme activity by the use of fertilizer in maize and inorganic input in the rice ecosystem. A field experiment (2021 to 2023) was carried out using synthetic fertilizer doses with maize
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Comparison of the first time detected Oesophagostomum asperum with Oesophagostomum columbianum in sheep and goats in Bangladesh based on the trinity: Morphology, morphometry and genetic diversity Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Nusrat Nowrin Shohana, Anita Rani Dey, Sharmin Aqter Rony, Shirin Akter, Bimal Chandra Karmakar, Mohammad Zahangir Alam
spp. (Family: Chabertiidae) is keeping a low profile in terms of severity in Bangladesh while maintaining economic loss through disguise within sheep and goats. The study was performed to identify prevalence, confirmation of species through morphology and morphometry followed by phylogeny using and genes. In total 384 slaughterhouse-sourced small and large intestines were pooled from Mymensingh, Kishoreganj
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Berberine modulates cardiovascular diseases as a multitarget-mediated alkaloid with insights into its downstream signals using in silico prospective screening approaches Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Sanaa Almowallad, Rehab Al-Massabi
Atherosclerosis is potentially correlated with several cardiac disorders that are greatly associated with cellular oxidative stress generation, inflammation, endothelial cells dysfunction, and many cardiovascular complications. Berberine is a natural isoquinoline alkaloid compound that widely modulates pathogenesis of atherosclerosis through its different curative potentials. This screening study was
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Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1 Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Mohammed Ageeli Hakami
The epigenetic regulation of lncRNA TUG1 has garnered significant attention in the context of diabetes and its associated disorders. TUG1′s multifaceted roles in gene expression modulation, and cellular differentiation, and it plays a major role in the growth of diabetes and the issues that are related to it due to pathological processes. In diabetes, aberrant epigenetic modifications can lead to dysregulation
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The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-10 Saif Aldeen Jaber
are one of the medicinal plants that commonly used in the treatment of different diseases. () is part of the species which grow in Jordan and used in traditional folklore medicine. The aim of this study is to confirm the ability of () leaves extracts to exert anticancer activity.
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Microbiological Quality Assessment of Skin and Body care Cosmetics by using Challenge test Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-28 Fatimah M. Alshehrei
Cosmetic products may be exposed to microbial contamination during storage or transport, and to avoid the risk of microbial growth, manufacturers add preservative compounds as a protection for the product from spoilage. The Microbial Challenge test is a procedure to evaluate the preservative efficacy by challenging the product with testing microorganisms to determine the quality of preservation. In
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Camel urine as a potential source of bioactive molecules showing their efficacy against pathogens: A systematic review Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-25 Ressmi Amina, Raqraq Habiba, Barguigua Abouddihaj
Camels are highly suited for severe desert conditions and able to provide most of the natural products like urine, which has been used as alternative medicine to treat diverse infections and disorders. There is, however, a shortage and paucity of scientific reviews highlighting the antifungal, antibacterial and antiviral effects of camel urine. By better understanding its antimicrobial characteristics
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In vitro and in silico studies of the potential cytotoxic, antioxidant, and HMG CoA reductase inhibitory effects of chitin from Indonesia mangrove crab (Scylla serrata) shells Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-25 Inarah Fajriaty, Irda Fidrianny, Neng Fisheri Kurniati, Norsyahida Mohd Fauzi, Sarmila Hanim Mustafa, I. Ketut Adnyana
This study aimed to characterize chitin extracted from Indonesia mangrove crab () shells, as well as to assess its cytotoxic, antioxidant, and HMG CoA reductase inhibitory potentials. molecular docking, molecular dynamic, and ADMET prediction analyses were also carried out. Chitin was extracted from mangrove crab shells using deproteination and demineralization processes, Scanning Electron Microscopy
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Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-23 Srivarshini Sankar, Gothandam Kodiveri Muthukaliannan
In terms of the economics and public health, chronic wounds exert a significant detrimental impact on the health care system. Bacterial infections, which cause the formation of highly resistant biofilms that elude standard antibiotics, are the main cause of chronic, non-healing wounds. Numerous studies have shown that phytochemicals are effective in treating a variety of diseases, and traditional medicinal
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Physiological responses and yield performance of selected rice (Oryza sativa L.) genotypes under deficit moisture stress Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-19 Khushi Rani Das, Farhana Zaman, Md. Moshiul Islam, Sazada Siddiqui, Mohammed O. Alshaharni, Uthman Balgith Algopishi
Rice is an important food crop, while it is severely affected by drought stress. Viewing this point in mind we conducted an experiment to see the physiological responses and yield potential of selected rice genotypes under inadequate moisture condition. Two soil moisture condition: one is sufficient moisture condition (control; 95–100% field capacity (FC)) and another is deficit moisture condition
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Antibacterial and antibiofilm potentials of Rumex dentatus root extract characterized by HPLC-ESI-Q-TOF-MS Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Imran Khan, Uzma Khan, Wajiha Khan, Aljawharah Alqathama, Muhammad Riaz, Rizwan Ahmad, Mohammad Mahtab Alam
The control of infections is one of the key strategies to treat cuts, wounds, lung, and skin infections. In this study the folkloric use of () roots in the mentioned conditions was scientifically investigated. The methanolic (MeOH) crude extract of root was fractionated (n-hexane, ethyl acetate and water) via bioassay-guided method, and its antibacterial activity was evaluated using the agar well diffusion
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Metabolic analysis of the CAZy class glycosyltransferases in rhizospheric soil fungiome of the plant species Moringa oleifera Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Sahar A. Alshareef
The target of the present work is to study the most abundant carbohydrate-active enzymes (CAZymes) of glycosyltransferase (GT) class, which are encoded by fungiome genes present in the rhizospheric soil of the plant species . The datasets of this CAZy class were recovered using metagenomic whole shotgun genome sequencing approach, and the resultant CAZymes were searched against the KEGG pathway database
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Targeting XGHPRT enzyme to manage Helicobacter pylori induced gastric cancer: A multi-pronged machine learning, artificial intelligence and biophysics-based study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Alhumaidi B. Alabbas
infects the stomach mucosa of over half of the global population and can lead to gastric cancer. This pathogen has demonstrated resistance to many frequently prescribed antibiotics, thereby underscoring the pressing need to identify novel therapeutic targets. The inhibition or disruption of nucleic acid biosynthesis constitutes a promising avenue for either restraining or eradicating bacterial proliferation
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Microbiological risk assessment and resistome analysis from shotgun metagenomics of bovine colostrum microbiome Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-16 Muhammad Yasir, Ibrahim A. Al-Zahrani, Raees Khan, Samah Abdullah Soliman, Safaa A. Turkistani, Maha Alawi, Esam I. Azhar
Colostrum is known for its nutraceutical qualities, probiotic attributes, and health benefits. The aim of this study was to profile colostrum microbiome from bovine in rural sites of a developing country. The focus was on microbiological safety assessments and antimicrobial resistance, taking into account the risks linked with the consumption of raw colostrum. Shotgun sequencing was employed to analyze
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Diversity of endophytic fungi from medicinal plant Oxalis latifolia and their antimicrobial potential against selected human pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-15 J.M. Hussein, H. Myovela, D.D. Tibuhwa
Endophytic fungi that inhabit medicinal plants are microbial resources renowned for having compounds analogous to those produced by their host plants. This study aimed to describe the diversity of endophytic fungi found in Kunth. To better understand the diversity of foliar endophytic fungi found in the leaves of the medicinal plant , we isolated and characterized endophytic by using both morphological
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Insights into cucumber (Cucumis sativus) genetics: Genome-wide discovery and computational analysis of the Calreticulin Domain-Encoding gene (CDEG) family Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-13 Pravej Alam, Thamer Albalawi
Cucumber is an essential vegetable crop throughout the world. Cucumber development is vital for accomplishing both quality and productivity requirements. Meanwhile, numerous factors have resulted in substantial cucumber losses. However, the calreticulin domain-encoding genes (CDEGs) in cucumber were not well-characterized and had little function. In the genome-wide association study (GWAS), we recognized
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Preparation and evaluation of antidiabetic activity of mangiferin-loaded solid lipid nanoparticles Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-08 Ahmed I. Foudah, Mohammad Ayman Salkini, Mohammed H. Alqarni, Aftab Alam
This study aimed to develop and optimize mangiferin-loaded solid lipid nanoparticles (MG-SLNs) using the microemulsion technique and ultrasonication. The MG-SLNs were composed of Labrafil M 2130 CS, MG, ethanol, Tween 80, and water. The optimized MG-SLNs exhibited a particle size of 138.37 ± 3.39 nm, polydispersity index of 0.247 ± 0.023, entrapment efficiency of 84.37 ± 2.43 %, and zeta potential
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Coproduction of alkaline protease and xylanase from genetically modified Indonesian local Bacillus halodurans CM1 using corncob as an inducing substrate Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-05 I Gede Eka Perdana Putra, Maria Ulfah, Niknik Nurhayati, Is Helianti
The production of corn generates a substantial amount of agro-industrial waste, with corncob accounting for a significant portion of this waste. In this study, we focused on utilizing corncob as a carbon source and inducer to simultaneously produce two valuable industrial enzymes, protease, and xylanase, using a recombinant strain of CM1. Interestingly, xylan-rich corncob not only enhanced the xylanase
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A novel approach to insulin delivery via oral route: Milk fat globule membrane derived liposomes as a delivery vehicle Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Shaheer Shafiq, Maisa Siddiq Abduh, Fareeha Iqbal, Kousain Kousar, Sadia Anjum, Tahir Ahmad
The current research endeavor seeks to unlock the potential of orally administered insulin formulations by utilizing liposomes derived from the fat globule membrane (MFGM) of camel milk as carriers for insulin. This pursuit emerges as a result of the recognized limitations of subcutaneous insulin therapy. The liposomes were meticulously created using the thin film hydration method, followed by comprehensive
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Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Roheena Abdullah, Qamar Younas, Afshan Kaleem, Mehwish Iqtedar, Mahwish Aftab, Faiza Saleem
In the current study the assessment of the antimicrobial and phytochemical properties of Cassia fistula, Musa paradisiaca, Ficus religiosa and Murraya koenigii plants extracts was carried out. The antibacterial potential of these plants extracts was tested against S. aureus and E. coli. The Cassia fistula and Ficus religiosa leaves showed the larger zone of inhibition in aqueous and butanolic extract
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Genetic variability and diversity analysis in Oryza sativa L. genotypes using quantitative traits and SSR markers Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Adel A. Rezk, Heba I. Mohamed, Hossam S. El-Beltagi
The present study was aimed at evaluating the genetic variation and population structure in a collection of 22 rice genotypes. Twenty-two rice genotypes were assessed using quantitative traits and SSR molecular markers for genetic variability and genetic diversity. As for genetic diversity, the genotypes were clarified based on twelve quantitative traits. Clustering produced two large groups: the IR70423-169-2-2
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In-silico characterization of GABAT protein found in gut-brain axis associated bacteria of healthy individuals and multiple sclerosis patients Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-02 Nadia Hussain, Fatima Muccee
Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and demyelination of neurons. There is evidence to suggest that level of a neurotransmitter gamma-aminobutyric acid (GABA), due to the degradation by γ-aminobutyric acid transaminase (GABAT), is reduced in certain areas of the brain in MS patients. MS is always accompanied by gut bacteria dysbiosis. In healthy individuals
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The geranium genus: A comprehensive study on ethnomedicinal uses, phytochemical compounds, and pharmacological importance Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Bader Alshehri
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Inter - and intraspecific phenotypic variation in co-occurring invasive and introduced cyprinid fish species Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Can Mert Gören, Nehir Kaymak
A species introduced outside of its native range will likely encounter unusual abiotic and biotic conditions,and may exhibit phenotypic traits that may facilitate survival and persistance. Phenotypic plasticity drives non-native species' development of adaptive traits in the new environment, increases their fitness, and as a result, contributes to invasion success. In this study, we examined inter
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Pandemic H1N1 influenza virus triggers a strong T helper cell response in human nasopharynx-associated lymphoid tissues Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Waleed H. Mahallawi, Omar F. Khabour
The pH1N1 belongs to influenza A family that is sometimes transmitted to humans via contact with pigs. Human tonsillar immune cells are widely used as in vitro models to study responses to influenza viruses. In the current study, human memory (M) and naïve (N) T cells responses in mononuclear cells of tonsil (TMCs) and peripheral blood (PBMCs) were stimulated by pH1N1/sH1N1, and then stained for estimation
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Analyzing bacterial persistence and dormancy: A bibliometric exploration of 21st century scientific literature Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-26 Lienda Bashier Eltayeb
In response to growing concerns about the efficacy of antibiotic treatment, there has been a significant increase in research on bacteria that are resistant to antibiotics over the past two centuries. Such investigations might bring a spotlight on the field's evolution and future prospects. The study was aimed at conducting a measurable bibliometric review of the scientific literature on bacterial
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Endophytic fungi of Tradescantia pallida Mediated targeting of Multi-Drug Resistant human pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Ranjitha Dhevi V. Sundar, Sathiavelu Arunachalam
Antimicrobial resistance (AMR) has emerged as one of the most serious worldwide public health issues of the twenty-first century. The expeditious rise of AMR has urged the development of new, natural effective therapeutic strategies against drug-resistant pathogens. Endophytic fungi, which inhabit distinctive environments like endosymbiotic relationships with plants, are gaining interest as alternative
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Exploring the role and mechanism of potential probiotics in mitigating the shrimp pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Manishkumar Tamilselvan, Sudhakaran Raja
Shrimp aquaculture has rapidly developed into a significant industry worldwide, providing not only financial gain and high-quality food but also tens of thousands of trained and competent workers. Frequent diseases are now regarded as a significant risk factor for shrimp aquaculture, as they have the potential to significantly reduce shrimp production and result in economic losses. Over the years various
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Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Abdullah Almilaibary
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Cell-free DNA as a potential diagnostic biomarker in academic stress: A case-control study in young adults Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-14 Muhammad Adnan Shan, Warda Ishtiaq, Shamsa Kanwal, Muhammad Umer Khan, Ayesha Iftikhar, Samiullah Khan
Background Stress is a pervasive issue in modern life, affecting both physical and mental health. Identifying biomarkers like cell-free DNA (cfDNA) could provide insights into stress response and help detect individuals at risk for stress-related disorders. Objective The aim of this study is to investigate the potential use of cfDNA as a diagnostic biomarker in individuals experiencing stress. Methodology
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Clinical applications of artificial intelligence in identification and management of bacterial infection: Systematic review and meta-analysis Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-14 Mohammad Zubair
Pneumonia is declared a global emergency public health crisis in children less than five age and the geriatric population. Recent advancements in deep learning models could be utilized effectively for the timely and early diagnosis of pneumonia in immune-compromised patients to avoid complications. This systematic review and meta-analysis utilized PRISMA guidelines for the selection of ten articles
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Improvement of renal functions in mice with septic acute kidney injury using secretome of mesenchymal stem cells Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-13 Arifin Arifin, Bambang Purwanto, Dono Indarto, Brian Wasita, Tatar Sumanjar, Eti Poncorini Pamungkasari, Soetrisno Soetrisno
Background A potentially fatal complication of sepsis is septic acute kidney injury. Stem cell therapy is a potential new method of treating sepsis and has been applied to treat some human diseases. Objectives This study investigated the effects of secretome-MSCs on NGAL, CRP, NF-κB, and MMP-9 proteins, and histopathology in mice with septic AKI. Methods A post-test-only group design was conducted
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Molecular cytogenetic analysis of multi-miscarriage products of conception in clinical cases from Al-Anbar Governorate, west of Iraq Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-12 Mushtak T.S. Al-Ouqaili, Rafal M. Murshid, Basma Y. Abd Al-Kariem, Bushra A. Kanaan, Ahmed T.S. Al-Neda
Most clinical miscarriages often occur throughout the first trimester of pregnancy, with fetal chromosomal abnormalities being identified as the primary reason for such occurrences. The objective is to analyze the fetal chromosomal aberrations in the product of conception among Iraqi patients suffering from recurrent miscarriages. The cross-sectional study was performed on 60 cases of products of conception
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Biochar-based organic fertilizers: Influence on yield and concentration of antioxidants in the stigma of saffron and rhizosphere bacterial diversity of slightly saline and non-saline soils Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-05 Shagufta Qasim, Shamim Gul, Abdul Hanan Buriro, Fahad Shafiq, Tariq Ismail
Being the most expensive spice, saffron has great economic importance. This crop grows well in cold arid deserts. Salinity is one of the important limiting factors for the cultivation of this crop. However, the use of composted manured and co-composted biochar and fertilizers can play a role in attenuating the salinity stress on this crop. In this two-year field study, manures from three sources: sheep
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Alleviation of carbendazim toxicity effect by Moringa oleifera oil and Linum usitatissimum L. oil on testes of male rats: Physiological, histological and in silico study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Muhammad Hashim, Atef M. Al-Attar, Mohammed Y. Alomar, Abdulkader M. Shaikh Omar, Naser A. Alkenani, Isam M. Abu Zeid
Carbendazim (CBZ) is a widely used fungicide that is used to control the unwanted growth of fungi on fruits and vegetables. Sixty male rats were divided into six groups, each having ten. Group one served as control, animals belonging to group two were exposed to CBZ in the measure of 200 mg/kg body weight (BW). In the third and fourth groups, rats were administered 800 mg/kg BW of Moringa oleifera
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An overview of multiple myeloma: A monoclonal plasma cell malignancy’s diagnosis, management, and treatment modalities Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Maisa Siddiq Abduh
Multiple Myeloma (MM) is a plasma cell cancer with high mortality and morbidity rates. Its incidence rate has increased by 143% since 1975. Adipokines, cytokines, chemokines, and genetic variations influence the development and progression of MM. Chromosomal translocations cause mutations associated with MM. The pathogenesis of MM is complicated by novel issues like miRNAs, RANKL, Wnt/DKK1, Wnt, and
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Integrative analysis of RNA expression data unveils distinct cancer types through machine learning techniques Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Saad Awadh Alanazi, Nasser Alshammari, Maddalah Alruwaili, Kashaf Junaid, Muhammad Rizwan Abid, Fahad Ahmad
Cancer is a highly complex and heterogeneous disease. Traditional methods of cancer classification based on histopathology have limitations in guiding personalized prognosis and therapy. Gene expression profiling provides a powerful approach to unraveling molecular intricacies and better-stratifying cancer subtypes. In this study, we performed an integrative analysis of RNA sequencing data from five
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Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive in silico and in vitro Study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Shazia sofi, Umar Mehraj, Nusrat Jan, Abdullah Almilaibary, Irshad Ahmad, Fuzail Ahmad, Manzoor Ahmad Mir
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Diversity, Distribution, and applications of arbuscular mycorrhizal fungi in the Arabian Peninsula Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-25 Khazna Alrajhi, Shazia Bibi, Mohammed Abu-Dieyeh
Investigations of arbuscular mycorrhizal fungi (AMF) received extreme interests among scientist including agronomists and environmental scientists. This interest is linked to advantages provided by AMF in enhancing the nutrients of their hosts via improving photosynthetic pigments and antioxidant production. Further, it also positively alters the production of plant hormones. AMF through its associations
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Association of genetic predisposition studies in CYP1A1 polymorphism studies in acute myeloid leukemia Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Abdullah Farasani
Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) gene is one of the sub-members of CYP450 family member and it encodes with the families of drug metabolizing enzyme families along with the cancers and leukemias. Among leukemias, AML is considered to be one of the important leukemia which attack the older adults. The aim of this study is to explore the role of A4889G polymorphism in CYP1A1 gene
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Stegomyia indices and pattern recognition of Aedes aegypti (Diptera: Culicidae) in selected agrogeoclimatic zones of Punjab, Pakistan Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Muhammad Abdullah Malik, Muhammad Sohail Sajid, Rasha Khalifah Al-Akeel, Mughees Aizaz Alvi, Hafiz Muhammad Rizwan, Haider Abbas, Mahvish Maqbool
Mosquito-borne diseases especially, dengue is gaining currency nowadays in Pakistan. As there is no approved dengue vaccine available worldwide, prevention and control of vector is the only solution amid prevailing circumstances. The present study is a maiden attempt to screen indoor and outdoor breeding containers for the presence of Aedes (Ae.) aegypti larvae from selected study districts of Punjab
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Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-16 Nada F. Alahmady, Fadwa M. Alkhulaifi, Maha Abdullah Momenah, Asmaa Ali Alharbi, Aminah Allohibi, Nouf H. Alsubhi, Wafaa Ahmed Alhazmi
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Identification of polymorphic alleles in TERC and TERT gene reprogramming the telomeres of newborn and legacy with parental health Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-12 Sadia farrukh, Saeeda Baig, Rubina Hussain, Rehan Imad, Ome kulsoom, Mehreen Yousaf Rana
Telomere and telomerase genes (TERC and TERT) highlighted many novel genetic polymorphisms related to common diseases. This study explored the polymorphic alleles of TERC and TERT gene in parents-newborn (triad) and its association with telomere length (TL) and parental diseases (mother: Gestational Diabetes Mellitus (GDM), Preeclampsia, fathers: Diabetes, Hypertension). In this cross-sectional study
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Examining the varied concentrations of Mentha spicata and Ocimum basilicum affect the synthesis of AgNPs that restrict the development of bacteria Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Motahher A. Qaeed
This work examined the effects of varied concentrations of Ocimum basilicum and Mentha spicata aqueous extracts in order to determine the concentration that has the strongest antibacterial impact through the green synthesis technique of silver nanoparticles (AgNPs). In order to synthesize AgNPs using the reduction method, different quantities of reducing and stabilizing agents: (a) 0.75 mM Ocimum basilicum
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Isolation, characterization, and cloning of thermostable pullulanase from Geobacillus stearothermophilus ADM-11 Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Dilara Abbas Bukhari, Zuhra Bibi, Arif Ullah, Abdul Rehman
This study aimed to identify thermo-stable pullulanase-producing bacteria in soil samples of potato fields and food-producing companies. Pullulan agar medium was used to screen 17 bacterial strains, which were incubated at 65 °C. The isolate with the maximum activity (375U/ml) was selected and recognized as Geobacillus stearothermophilus ADM-11 by morphological, biochemical characterization, and 16S
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Vitamin E reduces oxidative stress in brains of male albino male rats undergoing immobilization Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Noorah Saleh Al-Sowayan, Reem Abdullah Almarzougi
Stress can lead to various health problems. Exposure to stress is linked to several diseases including cancer, hypertension, diabetes, mental disorders, and heart attacks. Stress stimulates several pathways that produce free radicals, which increases oxidative stress. This results in functional and structural damage to organs, such as the brain, which is highly sensitive to oxidative stress Vitamin
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Prognostic significance and expression pattern of glucose related genes in breast cancer: A comprehensive computational biology approach Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Bader Alshehri
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Morphological, molecular identification and evaluation of antioxidant activity of seahorses from the Moroccan coasts Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Mohamed Rida Salam, Abdelkarim Ezaouine, Hasnae Zekhnini, Mariame El Messal, Fatiha El Mellouli, Fatima Chegdani, Faiza Bennis
Seahorses, part of the small marine teleost fish family Syngnathidae, are increasingly under threat due to habitat degradation and overfishing. Notably used in traditional Chinese medicine, these fish have demonstrated significant pharmacological and cosmetic properties. In Morocco, however, seahorses are minimally exploited. This study aims to explore the biodiversity of Moroccan seahorses, focusing
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Morphological, phytochemical and genetic characterization of Centella asiatica accessions collected throughout Vietnam and Laos Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-03 Hai Thi Hong Truong, Nhi Thi Hoang Ho, Han Ngoc Ho, Bao Le Quy Nguyen, Minh Hoang Duy Le, Thuy Thanh Duong
Pennywort (Centella asiatica L.) is commonly grown in the tropical world for its nutritional and medicinal values. Valuable saponins in pennywort are extensively investigated for their anti-tumour activities. The diversity in morphology, phytochemical contents and genetics among pennywort accessions has been extensively studied to identify elite landraces for large-scale production. While pennywort
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Efficacy of chitosan nanoparticles and wax coatings on maintaining post-harvest quality of “Murcott” mandarins Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-02 Nourah A. Al Zahrani, Mohamed M. Gad, Ahmed M. Fikry, Ahmed Ezzat Ahmed, Khaled A. El-Tarabily, Hend A. Elakkad, Ibrahim Eid Elesawi
Because of its high degree of biodegradability, chitosan is widely used as a component in food packaging. However, its poor physical properties, such as permeability, limit its applicability. Consequently, applying nano chitosan is regarded as the most effective solution to this issue. In the current study, we studied the effect of using different materials in the coating process on the quality of
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Nutrients and phytochemical density in Mesembryanthemum crystallinum L. cultivated in growing media supplemented with dosages of nitrogen fertilizer Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-26 Siphamandla Cebani, Muhali Olaide Jimoh, Avela Sogoni, Carolyn Margaret Wilmot, Charles Petrus Laubscher
Mesembryanthemum crystallinum L. is an annual halophyte that originated from southern Africa. However, little has been reported about factors that modulate the quantity of secondary metabolites in the plant. In this study, the twin effect of different nitrogen concentrations (0.36, 0.6, 0.8 g/L) and growing media (LECA clay, peat, vermiculite and silica sand) on plant growth, chlorophyll contents,
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Review green synthesis of silver nanoparticles by using plant extracts and their antimicrobial activity Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-26 Emad Abada, Abdullah Mashraqi, Yosra Modafer, Mohamed A. Al Abboud, A. El-Shabasy
Interest in the biosynthesis of nanoparticles has increased in the last era by researchers. Nanoparticles have several applications in different fields like optoelectronics, magnetic devices, drug delivery, and sensors. Nanoparticle synthesis by green methods is safe for the environment and should be explored and encouraged popularly since various plants' have the high extent to form these nanoparticles
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The impact of circulating 25-hydroxyvitamin D and vitamin D receptor variation on leukemia-lymphoma outcome: Molecular and cytogenetic study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Zahraa A. Abdulrazaq, Mushtak T.S. Al-Ouqaili, Nabeel M. Talib
Vitamin D (VD) potentially has a crucial function in the development of cancerous cells. This study aims to detect the role of vitamin D concentration and its receptor polymorphisms as possible prognostic biomarkers in patients with leukemia/lymphoma and further will attempt to detect the presence of the Philadelphia chromosome abnormality in chronic myeloid leukemia (CML). Seventy-five patients, in
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Epidemiology of feline bartonellosis and molecular characteristics of Bartonella henselae in Bangladesh Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Ajran Kabir, Chandra Shaker Chouhan, Tasmia Habib, Mahbubul Pratik Siddique, K.H.M. Nazmul Hussain Nazir, A.K.M. Anisur Rahman, Md. Amimul Ehsan
Bartonellosis, a neglected vector-borne zoonotic disease transmitted from animals to humans, continues to threaten human and animal health significantly. This study aims to determine the epidemiology of feline bartonellosis and the molecular characteristics of Bartonella spp. in cats. From June 2018 to June 2020, 304 oral swabs were randomly collected from Bangladesh's Dhaka, Mymensingh, and Rajshahi
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Phytochemical analysis, GC–MS profile and determination of antibacterial, antifungal, anti-inflammatory, antioxidant activities of peel and seeds extracts (chloroform and ethyl acetate) of Tamarindus indica L Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Adinath N. Tavanappanavar, Sikandar I. Mulla, Chandra Shekhar Seth, Zabin K. Bagewadi, Mohamed Rahamathulla, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana
Tamarindus indica L., is widely used tree in ayurvedic medicine. Here, we aimed to understand the presence of important constituents in seeds and peel of Tamarind fruits and their biological activities. Hence, seeds and peel of Tamarind fruits are used for further extraction process by soxhlet method (chloroform and ethyl acetate solvents). Results suggest that the ethyl acetate extract (seeds) consists
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Marine polychaete Namalycastis sp. extracts enhance proliferation and regeneration of mice 3T3 fibroblast and MCR-5 human fibroblast cells Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Maziah M. Ghazaly, Gaik Ee Lee, Nur Fariza M. Shaipulah, Yusof S. Ibrahim, Arifullah Mohammed
The Nereidid worm is a marine polychaete commonly found near the Nipa palm (Nypa fructicans) along the mangrove estuary. Recently, many usages have been documented for this polychaete family. Nevertheless, the true potentials of these marine worms, especially Namalycastis sp., from the medical perspective are still unknown. The current study investigated the cytotoxicity effect of Namalycastis sp.
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Beneficial probiotic bacteria prevalence in different lactating dromedary camel milk of Saudi Arabia Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Abdullah Sheikh, Hairul Islam Mohamed Ibrahim, Faisal Almathen, Mohammed Alfattah, Ashraf Khalifa
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Designing of fragment based inhibitors with improved activity against E. coli AmpC β-lactamase compared to the conventional antibiotics Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-11-25 Sidrah Hafeez, Rehan Zafar Paracha, Fazal Adnan
One of the most common primary resistance mechanism of multi-drug resistant (MDR) Gram negative pathogenic bacteria to combat β-lactam antibiotics, such as penicillins, cephalosporins and carbapenems is the generation of β- lactamases. The uropathogenic E. coli is mostly getting multi-drug resistance due to the synthesis of AmpC β-lactamases and therefore new antibiotics and inhibitors are needed to