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Bacillus cereus sensu lato antimicrobial arsenal: an overview Microbiol. Res. (IF 6.7) Pub Date : 2024-03-18 Louis Morandini, Simon Caulier, Claude Bragard, Jacques Mahillon
The Bacillus cereus group contains genetically closed bacteria displaying a variety of phenotypic features and lifestyles. The group is mainly known through the properties of three major species: the entomopathogen Bacillus thuringiensis, the animal and human pathogen Bacillus anthracis and the foodborne opportunistic strains of B. cereus sensu stricto. Yet, the actual diversity of the group is far
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A mitochondrial NAD/NADH kinase governs fungal virulence through an oxidative stress response and arginine biosynthesis in Fusarium graminearum Microbiol. Res. (IF 6.7) Pub Date : 2024-03-15 Jiyeun Park, Nahyun Lee, Hun Kim, Dohun Kim, Soobin Shin, Soyoung Choi, Gyung Ja Choi, Hokyoung Son
NADP/NADPH plays an indispensable role in cellular metabolism, serving as a pivotal cofactor in numerous enzymatic processes involved in anabolic pathways, antioxidant defense, and the biosynthesis of essential cellular components. NAD/NADH kinases (NADKs) phosphorylate NAD/NADH, constituting the sole synthetic pathway for NADP/NADPH generation. Despite the pivotal role of NADP/NADPH in cellular functions
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Biocontrol mechanism of Bacillus siamensis sp. QN2MO-1 against tomato fusarium wilt disease during fruit postharvest and planting Microbiol. Res. (IF 6.7) Pub Date : 2024-03-14 Miaoyi Zhang, Xiaojuan Li, Yongbo Pan, Dengfeng Qi, Dengbo Zhou, Yufeng Chen, Junting Feng, Yongzan Wei, Yankun Zhao, Kai Li, Wei Wang, Lu Zhang, Jianghui Xie
Tomato fusarium wilt caused by f. sp. () is a highly destructive disease, resulting in severe economic losses of global tomato production annually. An eco-friendly alternative to chemical fungicide using biological control agents (BCAs) is urgently needed. Here, QNMO-1 was isolated from Noli fruit and had a strong antagonistic activity against and . Strain QNMO-1 also exhibited a broad-spectrum antifungal
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Isolation of Saccharomycopsis species from plant material Microbiol. Res. (IF 6.7) Pub Date : 2024-03-13 Carmen Dost, Florian Michling, Davies Kaimenyi, Mareike Rij, Jürgen Wendland
species are natural organic sulphur auxotrophs. Their genomes do not encode genes for the uptake and assimilation of sulphate and thus these species cannot grow on media lacking e.g. methionine. Due to the similarity between sulphate and selenate, uptake and assimilation of selenate occurs through the same pathway starting from sulphate transporters encoded by the homologs of the and genes in . Lack
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Responses of growth performance, immunity, disease resistance of shrimp and microbiota in Penaeus vannamei culture system to Bacillus subtilis BSXE-1601 administration: Dietary supplementation versus water addition Microbiol. Res. (IF 6.7) Pub Date : 2024-03-12 Kai Luo, Zeyang Guo, Yang Liu, Changlin Li, Zhenhua Ma, Xiangli Tian
This study evaluated the effects of BSXE-1601, applied either as dietary supplementation or water addition, on growth performance, immune responses, disease resistance of , and microbiota in shrimp gut and rearing water. During the 42-day feeding experiment, shrimp were fed with basal diet (CO and BW group), basal diet supplemented with live strain BSXE-1601 at the dose of 1 × 10 CFU kg feed (BD group)
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A molecular overview of the polymyxin-LPS interaction in the context of its mode of action and resistance development Microbiol. Res. (IF 6.7) Pub Date : 2024-03-12 Indira Padhy, Sambit K. Dwibedy, Saswat S. Mohapatra
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action and the emergence of resistance to the existing drugs. Polymyxin, a cationic antimicrobial lipopeptide, is used to treat infections by Gram-negative bacterial pathogens as a last option. Though polymyxins were identified
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Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite Microbiol. Res. (IF 6.7) Pub Date : 2024-03-09 Andrew Tony-Odigie, Alexander H. Dalpke, Sébastien Boutin, Buqing Yi
In cystic fibrosis (CF), infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of . Through a screening study
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Effects of different dwarfing interstocks on the rhizosphere, endophytic bacteria, and drought resistance of apple trees Microbiol. Res. (IF 6.7) Pub Date : 2024-03-09 Yang Cao, Zhongyong Li, Peihua Du, Jiahao Ji, Wei Sun, Jizhong Xu, Bowen Liang
Rootstock is commonly used to enhance plant resistance to drought stress. However, it is necessary to investigate the effects of different rootstock, interstock, and scion combinations on rhizosphere and root endophytic bacteria under drought stress. We conducted a pot experiment to investigate how interstock [SH40, Jizhen 1 (J1), and Jizhen 2 (J2)] affects the drought tolerance and nitrogen (N) uptake
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Biocompatibility of Brazilian native yeast-derived sophorolipids and Trichoderma harzianum as plant-growth promoting bioformulations Microbiol. Res. (IF 6.7) Pub Date : 2024-03-08 Thiago Moura Rocha, Paulo Ricardo Franco Marcelino, Felipe Antonio Fernandes Antunes, Salvador Sánchez-Muñoz, Júlio César dos Santos, Silvio Silvério da Silva
The replacement of agrochemicals by biomolecules is imperative to mitigate soil contamination and inactivation of its core microbiota. Within this context, this study aimed at the interaction between a biological control agent such as CCT 2160 (BF-Th) and the biosurfactants (BSs) derived from the native Brazilian yeast UFMG-CM-Y6419. Thereafter, their potential in germination of L. seeds was tested
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Microbial regulation of plant secondary metabolites: Impact, mechanisms and prospects Microbiol. Res. (IF 6.7) Pub Date : 2024-03-08 Jiayan Lv, Shuangyu Yang, Wei Zhou, Zhongwang Liu, Jinfang Tan, Mi Wei
Plant secondary metabolites possess a wide range of pharmacological activities and play crucial biological roles. They serve as both a defense response during pathogen attack and a valuable drug resource. The role of microorganisms in the regulation of plant secondary metabolism has been widely recognized. The addition of specific microorganisms can increase the synthesis of secondary metabolites,
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Modulators targeting protein-protein interactions in Mycobacterium tuberculosis Microbiol. Res. (IF 6.7) Pub Date : 2024-03-07 Guofeng Luo, Tianqi Ming, Luchuan Yang, Lei He, Tao Tao, Yanmei Wang
Tuberculosis (TB) is a chronic infectious disease caused by (), mainly transmitted through droplets to infect the lungs, and seriously affecting patients' health and quality of life. Clinically, anti-TB drugs often entail side effects and lack efficacy against resistant strains. Thus, the exploration and development of novel targeted anti-TB medications are imperative. Currently, protein-protein interactions
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Unraveling the functional characteristics of endophytic bacterial diversity for plant growth promotion and enhanced secondary metabolite production in Pelargonium graveolens Microbiol. Res. (IF 6.7) Pub Date : 2024-03-07 Nikky Deepa, Shivam Chauhan, Akanksha Singh
The rich diversity of microbial endophytic communities associated with plants, often referred to as the second genome, serves as a compelling illustration of efficient co-evolution. This noteworthy partnership plays a pivotal role in sustaining plant well-being and enhancing plant adaptability across diverse habitats. Therefore, examining the diversity of endophytic microbes associated with their particular
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Unleashing Bacillus species as versatile antagonists: Harnessing the biocontrol potentials of the plant growth-promoting rhizobacteria to combat Macrophomina phaseolina infection in Gloriosa superba Microbiol. Res. (IF 6.7) Pub Date : 2024-03-06 Shanmugapriya Dhanabalan, Karthikeyan Muthusamy, Johnson Iruthayasamy, Parthiban V. Kumaresan, Caroline Ravikumar, Rajamani Kandasamy, Senthil Natesan, Sambasivam Periyannan
Charcoal rot caused by is one of the most devastating diseases that cause severe yield loss in cultivation. Plant growth-promoting rhizobacteria (PGPR) are extensively harnessed as biocontrol agents due to their effectiveness in combating a wide array of plant pathogens through a multifaceted approach. The present study delved into the mechanisms underlying its ability to inhibit root rot pathogen
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Unveiling the immunomodulatory effect of the novel probiotic Akkermansia muciniphila and its protective effect in vitro Microbiol. Res. (IF 6.7) Pub Date : 2024-03-06 Alba Calvo, Yadira Pastor, Pablo Rosas-Val, Carlos Gamazo
, a bacterium found in the human microbiota, has gained interest due to its potential health benefits. Previous studies have linked its absence to inflammatory disorders, while also suggesting its role in maintaining a healthy gut barrier. However, there is limited information on its specific effects on the immune system. Therefore, the aim of this research was to analyze the response triggered by
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Current insight into the role of mRNA decay pathways in fungal pathogenesis Microbiol. Res. (IF 6.7) Pub Date : 2024-03-06 Zulikha Firdous, Sapna Kalra, Rituja Chattopadhyay, Vinay Kumar Bari
Pathogenic fungal species can cause superficial and mucosal infections, to potentially fatal systemic or invasive infections in humans. These infections are more common in immunocompromised or critically ill patients and have a significant morbidity and fatality rate. Fungal pathogens utilize several strategies to adapt the host environment resulting in efficient and comprehensive alterations in their
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When and how did the names Bacteria and Eubacteria originate: Resurrected facts Microbiol. Res. (IF 6.7) Pub Date : 2024-03-05 Yegor Shɨshkin-Skarð
Here, I would like to overview an overlooked part of the nomenclatural history of the bacterial domain of life. The usage of the word Bacteria was quite wide before Ferdinand Cohn’s famous 1872 work to which it is now ascribed. This word applied to microorganisms appeared 27 years before this (in 1845). Also, the name Eubacteria appeared three years earlier than is thought now (in 1883). Both arose
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Colonization and spreading dynamics of Lactiplantibacillus plantarum spoilage isolates on wet surfaces Microbiol. Res. (IF 6.7) Pub Date : 2024-03-05 P. Rashtchi, D. Sudmalis, E. van der Linden, T. Abee, Mehdi Habibi
The role of lactic acid bacteria, including in food spoilage is well recognized, while the behavior of these non-motile bacteria on wet surfaces, such as those encountered in food processing environments has gained relatively little attention. Here, we observed a fast colony spreading of non-motile spoilage isolates on wet surfaces via passive sliding using solid BHI agar media as a model. We investigated
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Discovering novel biomarkers for diagnosis and treatment monitoring of active pulmonary tuberculosis by ion metabolism analysis Microbiol. Res. (IF 6.7) Pub Date : 2024-03-02 Qishun Feng, Qiao Lin, Fusheng Yao, Yunli Liao, Huihua Zhang, Yunmei Sun, Wenfeng Liu, Ruiqi Zhang, Weiqiao Rao, Guoliang Zhang, Yuzhong Xu
Tuberculosis (TB) is a highly lethal infectious disease that poses a global threat. Timely and accurate biomarker for TB diagnosis and treatment monitoring remains a pressing need. Ions, the crucial trace element for humans, may be potential targets for TB diagnosis and the forecasting of TB development. To explore the potential of ions as biomarkers, we measured and compared the levels of various
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Early detection of OXA-232-producing Klebsiella pneumoniae in China predating its global emergence Microbiol. Res. (IF 6.7) Pub Date : 2024-03-02 Heng Heng, Xuemei Yang, Haoshuai Zhang, Ruanyang Sun, Lianwei Ye, Jun Li, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
Antibiotic resistance is a global health issue, with (KP) posing a particular threat due to its ability to acquire resistance to multiple drug classes rapidly. OXA-232 is a carbapenemase that confers resistance to carbapenems, a class of antibiotics often used as a last resort for treating severe bacterial infections. The study reports the earliest known identification of six OXA-232-producing KP strains
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Body size mediates the functional potential of soil organisms by diversity and community assembly across soil aggregates Microbiol. Res. (IF 6.7) Pub Date : 2024-03-01 Guofan Zhu, Lu Luan, Shungui Zhou, Francisco Dini-Andreote, Mohammad Bahram, Yunfeng Yang, Stefan Geisen, Jie Zheng, Shaopeng Wang, Yuji Jiang
Body size is an important life-history trait that affects organism niche occupancy and ecological interactions. However, it is still unclear to what extent the assembly process of organisms with different body sizes affects soil biogeochemical cycling processes at the aggregate level. Here, we examined the diversity and community assembly of soil microorganisms (bacteria, fungi, and protists) and microfauna
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Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application Microbiol. Res. (IF 6.7) Pub Date : 2024-03-01 Yijing Yan, Wenlan Zhang, Yulin Wang, Chunmei Yi, Bin Yu, Xiaoli Pang, Kunyang Li, HuHu Li, Yongna Dai
The interaction of iron and intestinal flora, both of which play crucial roles in many physiologic processes, is involved in the development of Metabolic syndrome (MetS). MetS is a pathologic condition represented by insulin resistance, obesity, dyslipidemia, and hypertension. MetS-related comorbidities including type 2 diabetes mellitus (T2DM), obesity, metabolism-related fatty liver (MAFLD), hypertension
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Targeted modulation of gut and intra-tumor microbiota to improve the quality of immune checkpoint inhibitor responses Microbiol. Res. (IF 6.7) Pub Date : 2024-02-29 WeiZhou Wang, JunYing Fan, Chi Zhang, Yuan Huang, Yue Chen, ShaoZhi Fu, JingBo Wu
Immune checkpoint inhibitor (ICI) therapies, such as those blocking the interaction of PD-1 with its ligands, can restore the immune-killing function of T cells. However, ICI therapy is clinically beneficial in only a small number of patients, and it is difficult to predict post-treatment outcomes, thereby limiting its widespread clinical use. Research suggests that gut microbiota can regulate the
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Comprehensive genomic and plasmid characterization of multidrug-resistant bacterial strains by R10.4.1 nanopore sequencing Microbiol. Res. (IF 6.7) Pub Date : 2024-02-28 Lianwei Ye, Xudong Liu, Ying Ni, Yating Xu, Zhiwei Zheng, Kaichao Chen, Qiao Hu, Lu Tan, Zhihao Guo, Chan Kwan Wai, Edward Wai Chi Chan, Runsheng Li, Sheng Chen
The escalating prevalence of multidrug-resistant (MDR) bacteria pose a significant public health threat. Understanding the genomic features and deciphering the antibiotic resistance profiles of these pathogens is crucial for development of effective surveillance and treatment strategies. In this study, we employed the R10.4.1 nanopore sequencing technology, specifically through the use of the MinION
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Nanocomposites against Pseudomonas aeruginosa biofilms: Recent advances, challenges, and future prospects Microbiol. Res. (IF 6.7) Pub Date : 2024-02-28 Basma A. Omran, Boo Shan Tseng, Kwang-Hyun Baek
is an opportunistic bacterial pathogen that causes life-threatening and persistent infections in immunocompromised patients. It is the culprit behind a variety of hospital-acquired infections owing to its multiple tolerance mechanisms against antibiotics and disinfectants. Biofilms are sessile microbial aggregates that are formed as a result of the cooperation and competition between microbial cells
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Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review Microbiol. Res. (IF 6.7) Pub Date : 2024-02-28 Chen Wang, Yu Gu, Qiao Chu, Xin Wang, Yiyun Ding, Xiali Qin, Tianyu Liu, Sinan Wang, Xiang Liu, Bangmao Wang, Hailong Cao
Nonresponse to biologic agents in patients with inflammatory bowel disease (IBD) poses a significant public health burden, and the prediction of response to biologics offers valuable insights for IBD management. Given the pivotal role of gut microbiota and their endogenous metabolites in IBD, we conducted a systematic review to investigate the potential of fecal microbiota and mucosal microbiota and
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Bioprospecting the roles of Trichoderma in alleviating plants’ drought tolerance: Principles, mechanisms of action, and prospects Microbiol. Res. (IF 6.7) Pub Date : 2024-02-28 Sulistya Ika Akbari, Dedat Prismantoro, Nandang Permadi, Nia Rossiana, Mia Miranti, Muhamad Shakirin Mispan, Zulqarnain Mohamed, Febri Doni
Drought-induced stress represents a significant challenge to agricultural production, exerting adverse effects on both plant growth and overall productivity. Therefore, the exploration of innovative long-term approaches for addressing drought stress within agriculture constitutes a crucial objective, given its vital role in enhancing food security. This article explores the potential use of , a well-known
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Tree phylogeny predicts more than litter chemical components in explaining enzyme activities in forest leaf litter decomposition Microbiol. Res. (IF 6.7) Pub Date : 2024-02-28 Shuhui Du, Lujun Wang, Haishui Yang, Qian Zhang
Litter decomposition is an important process in ecosystem and despite recent research elucidating the significant influence of plant phylogeny on plant-associated microbial communities, it remains uncertain whether a parallel correlation exists between plant phylogeny and the community of decomposers residing in forest litter. In this study, we conducted a controlled litterbag experiment using leaf
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Essential roles of ferric reductase-like proteins in growth, development, stress response, and virulence of the filamentous entomopathogenic fungus Beauveria bassiana Microbiol. Res. (IF 6.7) Pub Date : 2024-02-27 Jin-Li Ding, Min Lu, Xiao-Long Liu, Ming-Guang Feng, Sheng-Hua Ying
In yeasts, ferric reductase catalyzes reduction of ferric ion to ferrous form, which is essential for the reductive iron assimilation system. However, the physiological roles of ferric reductases remain largely unknown in the filamentous fungi. In this study, genome-wide annotation revealed thirteen ferric reductase-like (Fre) proteins in the filamentous insect pathogenic fungus , and all their functions
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4-(Benzyloxy)phenol-induced p53 exhibits antimycobacterial response triggering phagosome-lysosome fusion through ROS-dependent intracellular Ca2+ pathway in THP-1 cells Microbiol. Res. (IF 6.7) Pub Date : 2024-02-24 Lincoln Naik, Salina Patel, Ashish Kumar, Abhirupa Ghosh, Abtar Mishra, Mousumi Das, Dev Kiran Nayak, Sudipto Saha, Amit Mishra, Ramandeep Singh, Assirbad Behura, Rohan Dhiman
Drug-resistant tuberculosis (TB) outbreak has emerged as a global public health crisis. Therefore, new and innovative therapeutic options like host-directed therapies (HDTs) through novel modulators are urgently required to overcome the challenges associated with TB. In the present study, we have investigated the anti-mycobacterial effect of 4-(Benzyloxy)phenol. Cell-viability assay asserted that 50 μM
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Beneficial roles of gastrointestinal and urinary microbiomes in kidney stone prevention via their oxalate-degrading ability and beyond Microbiol. Res. (IF 6.7) Pub Date : 2024-02-23 Chadanat Noonin, Visith Thongboonkerd
Formation of calcium oxalate (CaOx) crystal, the most common composition in kidney stones, occurs following supersaturation of calcium and oxalate ions in the urine. In addition to endogenous source, another main source of calcium and oxalate ions is dietary intake. In the intestinal lumen, calcium can bind with oxalate to form precipitates to be eliminated with feces. High intake of oxalate-rich foods
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Arbuscular mycorrhizal fungi drive bacterial community assembly in halophyte Suaeda salsa Microbiol. Res. (IF 6.7) Pub Date : 2024-02-23 Fengwei Diao, Bingbing Jia, Junqing Luo, Shengli Ding, Tai Liu, Wei Guo
Halophytes inhabit saline soils, wherein most plants cannot grow, therefore, their ecological value is outstanding. Arbuscular mycorrhizal (AM) fungi can reconstruct microbial communities to assist plants with stress tolerance. However, little information is available on the microbial community assembly of AM fungi in halophytes. A pot experiment was conducted to investigate the effects of AM fungi
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Polarity-dependent expression and localization of secretory glucoamylase mRNA in filamentous fungal cells Microbiol. Res. (IF 6.7) Pub Date : 2024-02-23 Yuki Morita, Kaoru Takegawa, Brett M. Collins, Yujiro Higuchi
In multinuclear and multicellular filamentous fungi little is known about how mRNAs encoding secreted enzymes are transcribed and localized spatiotemporally. To better understand this process we analyzed mRNA encoding GlaA, a glucoamylase secreted in large amounts by the industrial filamentous fungus , by the MS2 system, in which mRNA can be visualized in living cells. We found that mRNA was significantly
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EvfG is a multi-function protein located in the Type VI secretion system for ExPEC Microbiol. Res. (IF 6.7) Pub Date : 2024-02-23 Wenjia Lu, Hao Lu, Xinyu Huo, Chenchen Wang, Zhaoran Zhang, Bingbing Zong, Gaoyan Wang, Wenqi Dong, Xiaodan Li, Yuying Li, Huanchun Chen, Chen Tan
The Type VI secretion system (T6SS) functions as a protein transport nanoweapon in several stages of bacterial life. Even though bacterial competition is the primary function of T6SS, different bacteria exhibit significant variations. Particularly in (), research into T6SS remains relatively limited. This study identified the uncharacterized gene within the T6SS cluster of RS218. Through our experiments
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Staphylococcus haemolyticus: An updated review on nosocomial infections, antimicrobial resistance, virulence, genetic traits, and strategies for combating this emerging opportunistic pathogen Microbiol. Res. (IF 6.7) Pub Date : 2024-02-22 Ciro César Rossi, Faizan Ahmad, Marcia Giambiagi-deMarval
, a key species of the genus, holds significant importance in healthcare-associated infections, due to its notable resistance to antimicrobials, like methicillin, and proficient biofilms-forming capabilities. This coagulase-negative bacterium poses a substantial challenge in the battle against nosocomial infections. Recent research has shed light on genomic plasticity, unveiling genetic elements responsible
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Phage formulations and delivery strategies: Unleashing the potential against antibiotic-resistant bacteria Microbiol. Res. (IF 6.7) Pub Date : 2024-02-21 Alice Chiapetti Bolsan, Gabrielli Vaz Sampaio, Heloisa Campeão Rodrigues, Samara Silva De Souza, Thiago Edwiges, Marina Celant De Prá, Naiana Cristine Gabiatti
Bacterial control promoted by bacteriophages (phages) is an attractive tool in the face of the antibiotic crisis triggered by the exacerbated use of these drugs. Despite the growing interest in using these viruses, some gaps still need answers, such as the protection and delivery of phages. Some limitation points involve the degradation of phage proteins by enzymes or inactivation in low-pH environments
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Anthropogenic vs. natural habitats: Higher microbial biodiversity pays the trade-off of lower connectivity Microbiol. Res. (IF 6.7) Pub Date : 2024-02-21 Lingzi Mo, Augusto Zanella, Andrea Squartini, Giulia Ranzani, Cristian Bolzonella, Giuseppe Concheri, Massimo Pindo, Francesca Visentin, Guoliang Xu
Climate change and anthropogenic disturbances are known to influence soil biodiversity. The objectives of this study were to compare the community composition, species coexistence patterns, and ecological assembly processes of soil microbial communities in a paired setting featuring a natural and an anthropogenic ecosystem facing each other at identical climatic, pedological, and vegetational conditions
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Cooperation of quorum sensing and central carbon metabolism in the pathogenesis of Gram-positive bacteria Microbiol. Res. (IF 6.7) Pub Date : 2024-02-21 Shuji Gao, Yuxin Wang, Shuo Yuan, Jing Zuo, Wenjie Jin, Yamin Shen, Daniel Grenier, Li Yi, Yang Wang
Quorum sensing (QS), an integral component of bacterial communication, is essential in coordinating the collective response of diverse bacterial pathogens. Central carbon metabolism (CCM), serving as the primary metabolic hub for substances such as sugars, lipids, and amino acids, plays a crucial role in the life cycle of bacteria. Pathogenic bacteria often utilize CCM to regulate population metabolism
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SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin Microbiol. Res. (IF 6.7) Pub Date : 2024-02-21 Qi Xiang, Jie Wu, Yuzheng Zhou, Linhao Li, Miao Tian, Guobao Li, Zheng Zhang, Yang Fu
The presence of a multibasic cleavage site in the Spike protein of SARS-CoV-2 makes it prone to be cleaved by Furin at the S1/S2 junction (aa. 685–686), which enhances the usage of TMPRSS2 to promote cell-cell fusion to form syncytia. Syncytia may contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammation. However, the role of other SARS-CoV-2 encoding
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Fecal microbiota transplantation ameliorates abdominal obesity through inhibiting microbiota-mediated intestinal barrier damage and inflammation in mice Microbiol. Res. (IF 6.7) Pub Date : 2024-02-20 Xiaoqiang Zhu, Lijun Zhao, Liang Lei, Yanhong Zhu, Jun Xu, Li Liu
Abdominal obesity (AO), characterized by the excessive abdominal fat accumulation, has emerged as a significant public health concern due to its metabolic complications and escalating prevalence worldwide, posing a more pronounced threat to human health than general obesity. While certain studies have indicated that intestinal flora contributed to diet-induced general obesity, the precise involvement
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Sesame bacterial wilt significantly alters rhizosphere soil bacterial community structure, function, and metabolites in continuous cropping systems Microbiol. Res. (IF 6.7) Pub Date : 2024-02-17 Ruiqing Wang, Xinsheng Li, Fengjuan Lv, Junhai He, Rujie Lv, Lingen Wei
Bacterial wilt is the leading disease of sesame and alters the bacterial community composition, function, and metabolism of sesame rhizosphere soil. However, its pattern of change is unclear. Here, the purpose of this study was to investigate how these communities respond to three differing severities of bacterial wilt in mature continuously cropped sesame plants by metagenomic and metabolomic techniques
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Phenogenetic profile and agronomic contribution of Azospirillum argentinense Az39T, a reference strain for the South American inoculant industry Microbiol. Res. (IF 6.7) Pub Date : 2024-02-15 G.A. Maroniche, M.L. Puente, J.E. García, E. Mongiardini, A. Coniglio, S. Nievas, M.M. Labarthe, F. Wisniewski-Dyé, E. Rodriguez Cáceres, M. Díaz-Zorita, F. Cassán
sp. is a plant growth-promoting rhizobacteria largely recognized for its potential to increase the yield of different important crops. In this work, we present a thorough genomic and phenotypic analysis of Az39 to provide new insights into the beneficial mechanisms of this microorganism. Phenotypic analyses revealed the following abilities: growth at 20–38 °C (optimum, 28 °C), pH 6.0–8.0 (optimum,
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Distribution and roles of Ligilactobacillus murinus in hosts Microbiol. Res. (IF 6.7) Pub Date : 2024-02-15 Zhou Chuandong, Jicong Hu, Jiawen Li, Yuting Wu, Chan Wu, Guanxi Lai, Han Shen, Fenglin Wu, Changli Tao, Song Liu, Wenfeng Zhang, Hongwei Shao
, a member of the genus, holds significant potential as a probiotic. While research on has been relatively limited compared to well-studied probiotic lactic acid bacteria such as and , a mounting body of evidence highlights its extensive involvement in host intestinal metabolism and immune activities. Moreover, its abundance exhibits a close correlation with intestinal health. Notably, beyond the intestinal
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Long-term benefit contribution of chemical and biological nematicide in coffee nematode management in soil microbial diversity and crop yield perspectives Microbiol. Res. (IF 6.7) Pub Date : 2024-02-12 Muhammad Siddique Afridi, Pablo Schulman, Victor Nardelli Castanheira Lacerda, Rafaela Araújo Guimaraes, Flavio Henrique Vasconcelos de Medeiros
The plant-parasitic root-knot nematode causes significant damage and is an important threat in plantations. The utilization of plant-beneficial microbes as biological control agents against sedentary endoparasitic nematodes has been a longstanding strategy. However, their application in field conditions to control root-knot nematodes and their interaction with the rhizospheric microbiota of coffee
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Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V Microbiol. Res. (IF 6.7) Pub Date : 2024-02-09 Longcheng Guo, Konstantin Stoffels, Jaap Broos, Oscar P. Kuipers
Antimicrobial peptides (AMPs) show promise as alternatives to traditional antibiotics for treating drug-resistant infections. Their adaptability and diverse sequence possibilities allow for rational design by modulating physicochemical determinants to achieve desired biological properties, transforming them into peptides for potential new therapies. Nisin, one of the best-studied AMPs, is believed
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The regulatory pathway of transcription factor MYB36 from Trichoderma asperellum Tas653 resistant to poplar leaf blight pathogen Alternaria alternata Aal004 Microbiol. Res. (IF 6.7) Pub Date : 2024-02-08 Bin Liu, Jing Han, Huifang Zhang, Yuxiao Li, Yibo An, Shida Ji, Zhihua Liu
In fungi, MYB transcription factors (TFs) mainly regulate growth, development, and resistance to stress. However, as major disease-resistance TFs, they have rarely been studied in biocontrol fungi. In this study, MYB36 of Tas653 (Ta) was shown to respond strongly to the stress caused by Aa1004. Compared with wild-type Ta (Ta-Wt), the inhibition rate of the knockout strain (Ta-Kn) on Aa1004 decreased
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Mechanisms on salt tolerant of Paenibacillus polymyxa SC2 and its growth-promoting effects on maize seedlings under saline conditions Microbiol. Res. (IF 6.7) Pub Date : 2024-02-08 Chengqiang Wang, Jian Pei, Hui Li, Xiuling Zhu, Yanan Zhang, Yanjun Wang, Wenjie Li, Zhongyue Wang, Kai Liu, Binghai Du, Juquan Jiang, Dongying Zhao
Soil salinity negatively affects microbial communities, soil fertility, and agricultural productivity and has become a major agricultural problem worldwide. Plant growth-promoting rhizobacteria (PGPR) with salt tolerance can benefit plant growth under saline conditions and diminish the negative effects of salt stress on plants. In this study, we aimed to understand the salt-tolerance mechanism of at
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Sub-MIC vancomycin enhances the antibiotic tolerance of vancomycin-intermediate Staphylococcus aureus through downregulation of protein succinylation Microbiol. Res. (IF 6.7) Pub Date : 2024-02-05 Yi Yang, Li Tan, Siyuan He, Bo Hao, Xiaonan Huang, Yumin Zhou, Weilong Shang, Huagang Peng, Zhen Hu, Ruolan Ding, Xiancai Rao
Bacteria develop tolerance after transient exposure to antibiotics, and tolerance is a significant driver of resistance. The purpose of this study is to evaluate the mechanisms underlying tolerance formation in vancomycin-intermediate (VISA) strains. VISA strains were cultured with sub-minimum inhibitory concentrations (sub-MICs) of vancomycin. Enhanced vancomycin tolerance was observed in VISA strains
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Transmission of azithromycin-resistant gene, erm(T), of Gram-positive bacteria origin to Klebsiella pneumoniae Microbiol. Res. (IF 6.7) Pub Date : 2024-02-03 Xuemei Yang, Haoshuai Zhang, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
The (T) gene encodes the 23 s rRNA methyltransferase and confers erythromycin resistance in Gram-positive bacteria, while has rarely been identified in Gram-negative bacteria. In this study, we identified a small IncQ1 plasmid of 6135 bp harboring the (T) gene in a clinical strain and confirmed the role of the (T) gene in mediating azithromycin resistance. This plasmid was found to be generated by
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Negative plant-soil feedback in Arabidopsis thaliana: Disentangling the effects of soil chemistry, microbiome, and extracellular self-DNA Microbiol. Res. (IF 6.7) Pub Date : 2024-02-02 Mohamed Idbella, Giuliano Bonanomi, Francesca De Filippis, Alessandro Foscari, Maurizio Zotti, Ahmed M. Abd-ElGawad, Taoufiq Fechtali, Guido Incerti, Stefano Mazzoleni
Nutrient deficiency, natural enemies and litter autotoxicity have been proposed as possible mechanisms to explain species-specific negative plant-soil feedback (PSF). Another potential contributor to negative PSF is the plant released extracellular self-DNA during litter decay. In this study, we sought to comprehensively investigate these hypotheses by using (L.) Heynh as a model plant in a feedback
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The SUMOylation pathway regulates the pathogenicity of Fusarium oxysporum f. sp. niveum in watermelon through stabilizing the pH regulator FonPalC via SUMOylation Microbiol. Res. (IF 6.7) Pub Date : 2024-02-02 Muhammad Noman, Yizhou Gao, Hui Wang, Xiaohui Xiong, Jiajing Wang, Dayong Li, Fengming Song
SUMOylation is a key post-translational modification, where small ubiquitin-related modifier (SUMO) proteins regulate crucial biological processes, including pathogenesis, in phytopathogenic fungi. Here, we investigated the function and mechanism of the SUMOylation pathway in the pathogenicity of f. sp. (), the fungal pathogen that causes watermelon Fusarium wilt. Disruption of key SUMOylation pathway
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Antimicrobial resistance spectrum and virulence characterization of Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis isolated from asymptomatic and diarrheal rhesus monkeys Microbiol. Res. (IF 6.7) Pub Date : 2024-02-01 Jie Wu, Quan Zhou, Haoxuan Qi, Weiqi Lan, Shujian Yang, Shengzhi Yang, Zhenxin Fan, Anyun Zhang
This study aims to deepen our understanding of the drug resistance and virulence characterization among gut bacteria in asymptomatic and diarrheal captive rhesus macaques (RMs). A total of 31 samples, including 8 asymptomatic RMs, 10 diarrheal RMs, and 1 dead RM, were collected from a breeding base in Sichuan, China, for bacterial isolation. As a result, (n = 23), (n = 22), (n = 10), (n = 10), (n = 2)
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Epidemiology and antimicrobial resistance of Salmonella serovars Typhimurium and 4,[5],12:i- recovered from hospitalized patients in China Microbiol. Res. (IF 6.7) Pub Date : 2024-02-01 Reshma B Nambiar, Mohammed Elbediwi, Abdelaziz Ed-dra, Beibei Wu, Min Yue
Global emergence of multidrug-resistant (MDR) serovar Typhimurium is a continuing challenge for modern healthcare. However, the knowledge, regarding the epidemiology of salmonellosis caused by the monophasic variant . 4,[5],12:i:- in hospitalized patients, is limited in China. To bridge this gap, we carried out a retrospective study to determine the antimicrobial resistance, trends, and risk factors
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Molecular insights into the mutualism that induces iron deficiency tolerance in sorghum inoculated with Trichoderma harzianum Microbiol. Res. (IF 6.7) Pub Date : 2024-01-28 Ahmad H. Kabir, Jeffrey L. Bennetzen
Iron (Fe) deficiency is a common mineral stress in plants, including sorghum. Although the soil fungus Trichoderma harzianum has been shown to mitigate Fe deficiency in some circumstances, neither the range nor mechanism(s) of this process are well understood. In this study, high pH-induced Fe deficiency in sorghum cultivated in pots with natural field soil exhibited a significant decrease in biomass
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Bacterial heat shock protein: A new crosstalk between T lymphocyte and macrophage via JAK2/STAT1 pathway in bloodstream infection Microbiol. Res. (IF 6.7) Pub Date : 2024-01-26 Sheng Yin, Yizhi Peng, YingRui Lin, Hongzheng Wu, Bingqi Wang, Xiaofan Wang, Wanxin Chen, Tianyao Liu, Huanqie Peng, Xianping Li, Jiake Xu, Min Wang
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Alter codon bias of the P. pastoris genome to overcome a bottleneck in codon optimization strategy development and improve protein expression Microbiol. Res. (IF 6.7) Pub Date : 2024-01-24 Siyu Zhang, Ru Lin, Luyao Cui, Tianyi Jiang, Jiacheng Shi, Chaoyu Lu, Pengfei Li, Mian Zhou
Apart from its role in translation, codon bias is also an important mechanism to regulate mRNA levels. The traditional frequency-based codon optimization strategy is rather efficient in organisms such as , but much less in yeast which is a popular host for heterologous protein expression. This is because that unlike , the preferred codons of are actually AU-rich and hence codon optimization for extremely
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A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the development of new therapies Microbiol. Res. (IF 6.7) Pub Date : 2024-01-19 Nuno A. Pedro, Nuno P. Mira
Vaginal infectious diseases caused by viruses and bacteria have been linked to the occurrence of dysbiosis, that is, a reduction in the abundance of the normally dominating vaginal Lactobacillus species. Mucosal infections in the vagina and/or vulva caused by Candida species, usually known as vulvovaginal candidiasis (or VVC), are among the leading causes of diseases in the vaginal tract. The existence
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Rad6, a ubiquitin conjugator required for insect-pathogenic lifestyle, UV damage repair, and genomic expression of Beauveria bassiana Microbiol. Res. (IF 6.7) Pub Date : 2024-01-18 Xin-Cheng Luo, Lei Yu, Si-Yuan Xu, Sheng-Hua Ying, Ming-Guang Feng
The E2 ubiquitin conjugator Rad6 is required for DNA damage bypass in budding yeast but remain functionally unknown in filamentous fungi. Here, we report pleiotropic effect of Rad6 ortholog in Beauveria bassiana, a wide-spectrum fungal insecticide. Global ubiquitination signal was greatly attenuated in the absence of rad6. The blocked ubiquitination led to severe growth defect, blocked asexual development
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The active ingredients in Chinese peony pods synergize with antibiotics to inhibit MRSA growth and biofilm formation Microbiol. Res. (IF 6.7) Pub Date : 2024-01-20 Yingshan Jin, Jianxing Lin, Haiqing Shi, Yinzhe Jin, Qingchao Cao, Yuting Chen, Yihong Zou, Yuanyue Tang, Qiuchun Li
Staphylococcus aureus (S. aureus) is a zoonotic pathogen that infects both humans and animals. The rapid spread of methicillin-resistant S. aureus (MRSA) and its resistance to antibiotics, along with its ability to form biofilms, poses a serious challenge to the clinical application of traditional antibiotics. Peony (Paeonia lactiflora Pall.) is a traditional Chinese medicine with multiple pharmacological
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Kss1 of Verticillium dahliae regulates virulence, microsclerotia formation, and nitrogen metabolism Microbiol. Res. (IF 6.7) Pub Date : 2024-01-15 Wenwen Li, Sa Li, Chen Tang, Steven J. Klosterman, Yonglin Wang