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The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291 Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-25 Sathursha Gunaratnam, Carine Diarra, Patrick D. Paquette, Noam Ship, Mathieu Millette, Monique Lacroix
Clostridioides difficile infections (CDI) result from antibiotic use and cause severe diarrhea which is life threatening and costly. A specific probiotic containing Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 has demonstrated a strong inhibitory effect on the growth of several nosocomial C. difficile strains by production of antimicrobial
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Lactobacillus Plantarum 299v Changes miRNA Expression in the Intestines of Piglets and Leads to Downregulation of LITAF by Regulating ssc-miR-450a Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-24 Qi Wang, Qian Sun, Jing Wang, Xiaoyu Qiu, Renli Qi, Jinxiu Huang
Lactiplantibacillus plantarum subsp. plantarum 299v (L. plantarum 299v) is one of the most important probiotic strains in animal health, but the molecular mechanisms of how it exerts health benefits remain unclear. The purpose of this study was to explore the changes in miRNA expression profiles in the intestinal tissues of piglets by L. plantarum 299v and to explore its possible molecular regulatory
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Alginate Nanoparticles Enhance Anti- Clostridium perfringens Activity of the Leaderless Two-Peptide Enterocin DD14 and Affect Expression of Some Virulence Factors Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-22 Hassan Zgheib, Yanath Belguesmia, Rabah Boukherroub, Djamel Drider
Here, we report a novel approach to improve the anti-Clostridium perfringens activity of the leaderless two-peptide enterocin 14 (EntDD14), produced by Enterococcus faecalis 14. This strategy consists of loading EntDD14 onto alginate nanoparticles (Alg NPs), which are made of a safe polymer. The resulting formulation (EntDD14/Alg NPs) was able to reduce up to four times the minimum inhibitory concentration
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Dietary Supplementation of Potential Probiotics Bacillus subtilis , Bacillus licheniformis , and Saccharomyces cerevisiae and Synbiotic Improves Growth Performance and Immune Responses by Modulation in Intestinal System in Broiler Chicks Challenged with Salmonella Typhimurium Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-18 Kambiz Fazelnia, Jafar Fakhraei, Hossein Mansoori Yarahmadi, Kumarss Amini
This study evaluates the effects of probiotics and synbiotics on the performance, immune responses, and intestinal morphology, and the expression of immunity-related genes of broiler chicks challenged with Salmonella typhimurium. Three hundred and sixty broiler chicks were divided into six groups, including broiler chicks challenged and non-challenged with S. typhimurium and fed with probiotic, synbiotic
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Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-κB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-18 Oleksandr Korotkyi, Alevtina Huet, Kateryna Dvorshchenko, Nazarii Kobyliak, Tetyana Falalyeyeva, Liudmyla Ostapchenko
The therapeutic potential of using probiotics to treat osteoarthritis (OA) has only recently been recognized, with a small number of animal and human studies having been undertaken. The aim of this study was to describe the effect of a probiotic composition (PB) and chondroitin sulfate (CS), administered separately or in combination, on Tlr2, Tlr4, Nfkb1, and Comp gene expression in cartilage and levels
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Neuroprotective Effects of Heat-Killed Lactobacillus plantarum 200655 Isolated from Kimchi Against Oxidative Stress Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-17 Min-Jeong Cheon, Na-Kyoung Lee, Hyun-Dong Paik
Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson’s disease, and Huntington’s disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed to evaluate the neuroprotective effects of heat-killed L. plantarum 200655. We incubated intestinal cells
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Potent Anti- Candida Fraction Isolated from Capsicum chinense Fruits Contains an Antimicrobial Peptide That is Similar to Plant Defensin and is Able to Inhibit the Activity of Different α-Amylase Enzymes Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-17 Mariana C. L. Aguieiras, Larissa M. Resende, Thaynã A. M. Souza, Celso S. Nagano, Renata P. Chaves, Gabriel B. Taveira, André O. Carvalho, Rosana Rodrigues, Valdirene M. Gomes, Érica O. Mello
Antimicrobial peptides (AMPs) are molecules present in several life forms, possess broad-spectrum of inhibitory activity against pathogenic microorganisms, and are a promising alternative to combat the multidrug resistant pathogens. The aim of this work was to identify and characterize AMPs from Capsicum chinense fruits and to evaluate their inhibitory activities against yeasts of the genus Candida
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In Vitro Assessment of Probiotic Potential of Saccharomyces Cerevisiae DABRP5 Isolated from Bollo Batter, a Traditional Goan Fermented Food Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-17 Rochelle Prunella Pereira, Reshma Jadhav, Abhishek Baghela, Delicia Avilla Barretto
Bollo is a traditional Goan fermented food in which coarse wheat/wheat and finger millet is leavened with toddy. We here isolated 42 yeast strains from Bollo batter. Initial screening of the isolates with probiotic properties yielded four yeast isolates (DABRP1, DABRP2, DABRP5 and DABRP12). These isolates exhibited tolerance to high bile salt concentration and acidic pH and resistance to various antibiotics
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The Anti-fibrotic Effects of Heat-Killed Akkermansia muciniphila MucT on Liver Fibrosis Markers and Activation of Hepatic Stellate Cells Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-12 Shahrbanoo Keshavarz Azizi Raftar, Sara Abdollahiyan, Masoumeh Azimirad, Abbas Yadegar, Farzam Vaziri, Arfa Moshiri, Seyed Davar Siadat, Mohammad Reza Zali
Hepatic stellate cell (HSC) activation is a key phenomenon in development of liver fibrosis. Recently, Akkermansia muciniphila has been introduced as a next-generation microbe residing in the mucosal layer of the human gut. Due to the probable risks associated with the use of live probiotics, the tendency to use heat-killed bacteria has been raised. Herein, we investigated the potential anti-fibrotic
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Lactobacillus rhamnosus CGMCC 1.3724 (LPR) Improves Skin Wound Healing and Reduces Scar Formation in Mice Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-12 Camila Francisco Moreira, Puebla Cassini-Vieira, Maria Cecília Campos Canesso, Mariane Felipetto, Hedden Ranfley, Mauro Martins Teixeira, Jacques Robert Nicoli, Flaviano Santos Martins, Lucíola Silva Barcelos
Skin wounds are an important clinical problem which affects millions of people worldwide. The search for new therapeutic approaches to improve wound healing is needed. The present study aimed to evaluate the effects of the oral treatment with the skin-related probiotics Lactobacillus johnsonii LA1 (LJ), L. paracasei ST11 (LP), and L. rhamnosus LPR (LR) in a model of excisional skin wounds in Swiss
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Craft Beers Fermented by Potential Probiotic Yeast or Lacticaseibacilli Strains Promote Antidepressant-Like Behavior in Swiss Webster Mice Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-11 Larissa Cardoso Silva, Heitor de Souza Lago, Márcia Oliveira Terra Rocha, Vanessa Sales de Oliveira, Roberto Laureano-Melo, Evandro Toledo Gerhardt Stutz, Breno Pereira de Paula, José Francisco Pereira Martins, Rosa Helena Luchese, André Fioravante Guerra, Paula Rodrigues
This study aimed to produce a probiotic-containing functional wheat beer (PWB) by an axenic culture system with potential probiotic Saccharomyces cerevisiae var boulardii 17 and probiotic-containing functional sour beer (PSB) by a semi-separated co-cultivation system with potential probiotic Lacticaseibacillus paracasei DTA 81 and Saccharomyces cerevisiae S-04. Additionally, results obtained from in
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Non-fermented Dairy Desserts with Potentially Probiotic Autochthonous Lactobacilli and Products from Peel of Jabuticaba ( Myrciaria cauliflora ) Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-06 Marina Cínthia de Sousa, Widson Michael dos Santos, Júlia Maria Orleans da Silva, Felipe Pereira Ramos, Aline Souza de Freitas, Maria Carmélia Almeida Neta, Karina Maria Olbrich dos Santos, Flávia Carolina Alonso Buriti, Eliane Rolim Florentino
The influence of two autochthonous lactobacilli strains with probiotic potential (Lactobacillus mucosae CNPC007 and Lactobacillus plantarum CNPC020) in comparison to a commercially available probiotic strain (Lactobacillus rhamnosus LR32) in non-fermented dairy desserts added with ingredients (syrup and hydroethanolic extract) derived from jabuticaba (Myrciaria cauliflora) peels was investigated. L
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In vitro and In vivo Antibacterial Effects of Nisin Against Streptococcus suis Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-06 Haodan Zhu, Lixiao Han, Yanxiu Ni, Zhengyu Yu, Dandan Wang, Junming Zhou, Bin Li, Wei Zhang, Kongwang He
Nisin is a promising therapeutic candidate because of its potent activity against Gram-positive bacteria. The present study aimed to describe the in vitro and in vivo antibacterial effects of nisin against Streptococcus suis, an important zoonotic pathogen. The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of nisin against different S. suis strains ranged from
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Efficacy of Probiotic Milk Formula on Blood Lipid and Intestinal Function in Mild Hypercholesterolemic Volunteers: A Placebo-control, Randomized Clinical Trial Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2021-01-06 Hui-Fang Chiu, Chia-Yuan Fang, You-Cheng Shen, Kamesh Venkatakrishnan, Chin-Kun Wang
Several studies have reported that probiotics could modulate host lipid metabolism via altering the intestinal microbiota. Hence, the current study was aimed to assess the efficacy of a mixture of probiotic-contained milk formula (PMF) with three different bacterial strains [Lactobacillus acidophilus (La5), Lactobacillus casei (TMC), Bifidobacterium lactis (Bb12)] on lipid profile and intestinal function
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Genomic Analysis for Antioxidant Property of Lactobacillus plantarum FLPL05 from Chinese Longevity People. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-31 Xiaomin Yu,Yijuan Li,Qinglong Wu,Nagendra P Shah,Hua Wei,Feng Xu
Antioxidant activity is one of the important probiotic characteristics for lactic acid bacteria including Lactobacillus plantarum, which is used for food fermentation or as a probiotic supplement. L. plantarum FLPL05 is a novel strain originally isolated from a healthy elderly individual of longevity. The organism has been demonstrated to exhibit high antioxidant property. However, there are limited
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Integrated Phenotypic-Genotypic Analysis of Candidate Probiotic Weissella Cibaria Strains Isolated from Dairy Cows in Kuwait Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-10-21 Vania Patrone, Tahani Al-Surrayai, Francesco Romaniello, Alessandra Fontana, Giovanni Milani, Valeria Sagheddu, Edoardo Puglisi, Maria Luisa Callegari, Hamad Al-Mansour, Mohamed Waheed Kishk, Lorenzo Morelli
Probiotics represent a possible strategy for controlling intestinal infections in livestock. Members of the Weissella genus are increasingly being studied for health-related applications in animals and humans. Here we investigated the functional properties of two Weissella cibaria strains isolated from cows reared in Kuwait breeding facilities by combining phenotypic with genomic analyses. W. cibaria
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Anti-Proliferative and Anti-Biofilm Potentials of Bacteriocins Produced by Non-Pathogenic Enterococcus sp. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-10-03 Fatma Molham, Ahmed S. Khairalla, Ahmed F. Azmy, Eman El-Gebaly, Ahmed O. El-Gendy, Sameh AbdelGhani
The incidence of cancer is increasing worldwide; likewise, the emergence of antibiotic-resistant biofilm-forming pathogens has led to a tremendous increase in morbidity and mortality. This study aimed to evaluate the probiotic properties of bacteriocin-producing Enterococcus sp. with a focus on their anti-biofilm and anticancer activities. Three of 79 Enterococcus isolates (FM43, FM65, FM50) were identified
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Impact of Supplements on Enhanced Activity of Bacillus amyloliquefaciens BmB1 Against Pythium aphanidermatum Through Lipopeptide Modulation Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-10-01 Aswani Ravi, Sukanya Rajan, Nejumal Kannankeril Khalid, Midhun Sebastian Jose, Charuvila T. Aravindakumar, Radhakrishnan Edayileveettil Krishnankutty
The present study has been designed to improve the activity of endophytic Bacillus amyloliquefaciens BmB1 against Pythium aphanidermatum through the culture supplementation with carbon sources, nitrogen sources and zinc oxide nanoparticles (ZnONPs). From the results of the study, supplementation with glucose (45 g/L), yeast extract (7.5 g/L) and ZnONPs (5 mg/L) were found to enhance the antifungal
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Probiotic Effects of Lactobacillus paracasei 28.4 to Inhibit Streptococcus mutans in a Gellan-Based Formulation. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-27 Janaína Araújo de Alvarenga,Patrícia Pimentel de Barros,Felipe de Camargo Ribeiro,Rodnei Dennis Rossoni,Maíra Terra Garcia,Marisol Dos Santos Velloso,Shashank Shukla,Beth Burgwyn Fuchs,Anita Shukla,Eleftherios Mylonakis,Juliana Campos Junqueira
Streptococcus mutans is considered to be a major bacterium involved in dental caries, and the control of virulence mechanisms is fundamental to prevent disease. Probiotics present a promising preventive method; however, the use of probiotics requires its incorporation into delivery materials to facilitate oral colonization. Thus, we performed a comprehensive study examining preventive effects of Lactobacillus
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Development and Comparative Evaluation of a Novel Fermented Juice Mixture with Probiotic Strains of Lactic Acid Bacteria and Bifidobacteria. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-25 Damla Güney,Mine Güngörmüşler
As being a rapidly developing area, the production of nondairy-based functional beverages continues to accelerate considerably. In the present study, the probiotification of a mixture of the juices of Jerusalem artichoke, pineapple, pumpkin, spinach, and cucumber has been utilized for the development of probiotic fruit-vegetable juice. Lactic acid fermentation was comparatively performed by Lactobacillus
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Analysis of miRNA Expression in the Ileum of Broiler Chickens During Bacillus licheniformis H2 Supplementation Against Subclinical Necrotic Enteritis. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-25 Ying Zhao,Dong Zeng,Hesong Wang,Ning Sun,Jinge Xin,Hanbo Yang,Lei Lei,Abdul Khalique,Danish Sharafat Rajput,Kangcheng Pan,Gang Shu,Bo Jing,Xueqin Ni
Subclinical necrotic enteritis (SNE) is one of the serious threats to the poultry industry. Probiotics have been proven to exert beneficial effects in controlling SNE. However, their exact mechanisms have not been fully elucidated. Moreover, few studies have focused on their impact on microRNAs (miRNAs). Therefore, the present study aimed to explore the miRNA expression profiles in the ileum of broiler
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Oral Administration of Live and Dead Cells of Lactobacillus sakei proBio65 Alleviated Atopic Dermatitis in Children and Adolescents: a Randomized, Double-Blind, and Placebo-Controlled Study. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-18 Irfan A Rather,Byung-Chun Kim,Lee-Ching Lew,Seong-Kwan Cha,Jong Hwan Lee,Gyeong-Jun Nam,Rajib Majumder,Jeongheui Lim,Seul-Ki Lim,Young-Joon Seo,Yong-Ha Park
Several studies suggest that probiotics might be useful in the management of atopic dermatitis (AD). However, the efficacy and comparison between both the administration of viable and non-viable probiotics on alleviation of AD is not well studied. Therefore, the purpose of this study was to evaluate the effect of L. sakei proBio65 live and dead cells when administered (1 × 1010 cells/day) for 12 weeks
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Characterization and Quantitative Determination of a Diverse Group of Bacillus subtilis subsp. subtilis NCIB 3610 Antibacterial Peptides. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-12 Angeliki Karagiota,Hara Tsitsopoulou,Rafail Nikolaos Tasakis,Varvara Zoumpourtikoudi,Maria Touraki
Five antibacterial peptides produced by Bacillus subtilis NCIB 3610 were purified, quantified, characterized, and identified in the present study. Cell-free extracts were subjected to three purification protocols employing ammonium sulfate or organic solvent precipitation and their combination, followed by ion-exchange chromatography, solid-phase extraction, and preparative high-performance liquid
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Synergistically-acting Enterocin LD3 and Plantaricin LD4 Against Gram-Positive and Gram-Negative Pathogenic Bacteria. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-12 Poonam Sheoran,Santosh Kumar Tiwari
The efficacy of antimicrobials is an important aspect during their applications in food and therapeutics. In this study, combination of two bacteriocins, enterocin LD3 and plantaricin LD4, was studied against two pathogenic bacteria, Staphylococcus aureus subsp. aureus ATCC25923 and Salmonella enterica subsp. enterica serovar Typhimurium ATCC13311 for increasing their potency and bactericidal activity
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Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-05 Morgan A Hitchner,Matthew R Necelis,Devanie Shirley,Gregory A Caputo
Antimicrobial peptides (AMPs) have been an area of great interest, due to the high selectivity of these molecules toward bacterial targets over host cells and the limited development of bacterial resistance to these molecules through evolution. The peptides are known to selectively bind to bacterial cell surfaces through electrostatic interactions, and subsequently, the peptides insert into the cell
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Impact of Potential Probiotic Lactobacillus Strains on Host Growth and Development in a Drosophila melanogaster Model. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-09-02 Pasaraporn Laomongkholchaisri,Rawee Teanpaisan,Monwadee Wonglapsuwan,Supatcharin Piwat
Lactobacillus paracasei SD1, Lactobacillus rhamnosus SD11, and Lactobacillus gasseri SD12 were proposed as potential probiotics for oral health. However, the effects of them on host physiology are still unknown. This study aimed to select strains that can promote host growth and development in monocolonized Drosophila model compared with axenic and the commercial Lactobacillus rhamnosus GG–treated
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Stimulation of Bovicin HC5 Production and Selection of Improved Bacteriocin-Producing Streptococcus equinus HC5 Variants. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-31 Sofia Magalhães Moreira,Tiago Antônio de Oliveira Mendes,Hilário Cuquetto Mantovani
Bovicin HC5 is a peptide that has inhibitory activity against various pathogenic microorganisms and food spoilage bacteria. Aiming to improve the productivity of this bacteriocin, we evaluated several potential factors that could stimulate the synthesis of bovicin HC5 and selected variants of Streptococcus equinus (Streptococcus bovis) HC5 with enhanced bacteriocin production by adaptive laboratory
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Effect of Lactobacillus delbrueckii Subsp. lactis PTCC1057 on Serum Glucose, Fetuin-A ,and Sestrin 3 Levels in Streptozotocin-Induced Diabetic Mice. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-29 Jamal Hallajzadeh,Reza Dolatyari Eslami,Asghar Tanomand
Intake of probiotic bacteria may improve or preserve insulin sensitivity. Fetuin-A and sestrin 3 have emerged as promising candidate biomarkers for crucial roles in insulin signaling pathway. Therefore, the effect of oral supplementation with the probiotic bacterium Lactobacillus delbrueckii subsp. lactis PTCC1057 on proteins involved in insulin signaling pathway was investigated in normal and streptozotocin
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The Administration Matrix Modifies the Beneficial Properties of a Probiotic Mix of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-26 Gréta Pápai,Edgar Torres-Maravilla,Florian Chain,Éva Varga-Visi,Otília Antal,Zoltán Naár,Luis G Bermúdez-Humarán,Philippe Langella,Rebeca Martín
Consumption of dairy products is one of the most natural ways to introduce probiotics. However, the beneficial effects of the probiotics might depend on the administration form. The aim of this study was to investigate the beneficial properties of two probiotic strains: Bifidobacterium animalis subsp. lactis (BB-12) and Lactobacillus acidophilus (LA-5) in different administration forms (capsules and
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The Effects of Lactobacillus plantarum-12 Crude Exopolysaccharides on the Cell Proliferation and Apoptosis of Human Colon Cancer (HT-29) Cells. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-26 Mengying Sun,Wenwen Liu,Yinglong Song,Yanfeng Tuo,Guangqing Mu,Fenglian Ma
The exopolysaccharide (EPS) of some Lactobacillus strains has been reported to exert anti-cancer activities. In this study, the effects of crude EPSs produced by four Lactobacillus plantarum strains (Lactobacillus plantarum-12, L. plantarum-14, L. plantarum-32, and L. plantarum-37) on HT-29 cell proliferation and apoptosis were studied. The results showed that the inhibition rate of the crude EPS produced
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Does the Future of Antibiotics Lie in Secondary Metabolites Produced by Xenorhabdus spp.? A Review. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-25 E Booysen,L M T Dicks
The over-prescription of antibiotics for treatment of infections is primarily to blame for the increase in bacterial resistance. Added to the problem is the slow rate at which novel antibiotics are discovered and the many processes that need to be followed to classify antimicrobials safe for medical use. Xenorhabdus spp. of the family Enterobacteriaceae, mutualistically associated with entomopathogenic
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Characterization of Lactic Acid Bacteria in Raw Buffalo Milk: a Screening for Novel Probiotic Candidates and Their Transcriptional Response to Acid Stress. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-23 Gabriela Merker Breyer,Nathasha Noronha Arechavaleta,Franciele Maboni Siqueira,Amanda de Souza da Motta
Lactic acid bacteria (LAB) are important microorganisms for the food industry due to their functional activity, as starters and potential probiotic strains. With that in mind, we explored the LAB diversity in raw buffalo milk, screening for novel potential probiotic strains. A total of 11 strains were identified by combination of MALDI-TOF and partial 16S rDNA sequencing and selected as potential probiotic
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The Effects of Kefir on Kidney Tissues and Functions in Diabetic Rats. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-20 Mustafa Kahraman,Yusuf Haydar Ertekin,İlhan Satman
This study was designed to determine the protective effect of kefir on the oxidative damage, as well as histological and biochemical changes that occur in the kidney tissues of experimental diabetic rats. Forty rats were allocated into four groups as “healthy saline” (SF), “healthy kefir” (KF), and the same groups with experimentally induced diabetes (DSF and DKF). Diabetes was induced by administering
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Characterization of Riboflavin-Producing Strains of Lactobacillus plantarum as Potential Probiotic Candidate through in vitro Assessment and Principal Component Analysis. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-18 Bharat Bhushan,Sumit M Sakhare,Kapil Singh Narayan,Mamta Kumari,Vijendra Mishra,Leon M T Dicks
Lactic acid bacteria (LAB) are known for their probiotic properties, but only a few strains produce riboflavin. We evaluated the probiotic properties of four riboflavin-producing strains of Lactobacillus plantarum (BBC33, BBC32A, BIF43, and BBC32B) by using in vitro assessment and carried out multivariate principal component analysis (PCA) to select the best strain. Safety, antioxidant, and exopol
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Postbiotic and Anti-aflatoxigenic Capabilities of Lactobacillus kunkeei as the Potential Probiotic LAB Isolated from the Natural Honey. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-15 Maryam Ebrahimi,Alireza Sadeghi,Delasa Rahimi,Hosein Purabdolah,Sara Shahryari
The use of probiotic, postbiotic, and anti-aflatoxigenic capabilities of the lactic acid bacteria (LAB) isolated from stressful niches is a major strategy to prepare functional cultures and bio-preservatives for food industries. In the present study, abundant LAB strains isolated from natural honey were screened based on their tolerance to continuous pH and bile salt treatments. Then, the pro-functional
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Combined Use of Bacillus subtilis yb-114,246 and Bacillus licheniformis yb-214,245 Improves Body Growth Performance of Chinese Huainan Partridge Shank Chickens by Enhancing Intestinal Digestive Profiles. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-11 Jiajun Yang,Kehe Huang,Jing Wang,Dong Wu,Zongliang Liu,Pengcheng Yu,Zhanyong Wei,Fu Chen
The aim of our study was to unveil the promoting function of compound Bacillus sp. in improving chicken digestion-induced higher body growth performance. Strains of Bacillus subtilis and B. licheniformis were jointly supplemented to the chick diet. Digestive enzyme activities in the digesta improved, development of intestinal villus enhanced, and duodenum and ileum villous height increased, while their
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Real-Time PCR Assays for the Specific Identification of Probiotic Strains Lactobacillus gasseri BNR17 and Lactobacillus reuteri LRC (NCIMB 30242). Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-11 Hanan R Shehata,Subramanyam Ragupathy,Shara Allen,Gregory Leyer,Steven G Newmaster
The broad spectrum of health benefits attributed to probiotics has contributed to a rapid increase in the value of the probiotic market. Probiotic health benefits can be strain specific. Thus, strain-level identification of probiotic strains is of paramount importance to ensure probiotic efficacy. Both Lactobacillus gasseri BNR17 and Lactobacillus reuteri LRC (NCIMB 30242) strains have clinically proven
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Evaluation of Porcine Intestinal Epitheliocytes as an In vitro Immunoassay System for the Selection of Probiotic Bifidobacteria to Alleviate Inflammatory Bowel Disease. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-10 Nana Sato,Mao Yuzawa,Md Islam Aminul,Mikado Tomokiyo,Leonardo Albarracin,Valeria Garcia-Castillo,Wakako Ideka-Ohtsubo,Noriyuki Iwabuchi,Jin-Zhong Xiao,Apolinaria Garcia-Cancino,Julio Villena,Haruki Kitazawa
The use of in vitro systems that allow efficient selection of probiotic candidates with immunomodulatory properties could significantly minimize the use of experimental animals. In this work, we generated an in vitro immunoassay system based on porcine intestinal epithelial (PIE) cells and dextran sodium sulfate (DSS) administration that could be useful for the selection and characterization of potential
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Potentially Probiotic Lactobacillus Strains Derived from Food Intensify Crystallization Caused by Proteus mirabilis in Urine. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-04 Agnieszka Torzewska,Paulina Wiewiura,Dominika Brodecka,Dominika Szczerbiec,Antoni Różalski
Proteus mirabilis is a common cause of infectious urolithiasis. The first stage in the formation of urinary stones is the crystallization of mineral salts in the urine induced by urease activity of this microorganism. Lactobacillus spp. are an important component of the human microbiota and in large quantities occur in foods. Regardless of their origin, those with probiotic properties are proposed
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The Effect of Antimicrobial Peptides on the Viability of Human Corneal Epithelial Cells. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-08-03 Ezgi Ulkuseven,David J McCanna,Lakshman N Subbaraman,Lyndon W Jones
Antimicrobial peptides are polypeptides composed of less than 100 amino acids and are a class of antibiotics with strong activity against some infectious bacteria. This study examined the safety of four chosen antimicrobial peptides using primary human corneal epithelial cells (HCEC) and explored their potential therapeutic use. The efficacy of the peptides was also studied by evaluating the minimum
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In Vitro Evaluation of Potential Probiotic Strain Lactococcus lactis Gh1 and Its Bacteriocin-Like Inhibitory Substances for Potential Use in the Food Industry. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-30 Roslina Jawan,Sahar Abbasiliasi,Shuhaimi Mustafa,Mohammad Rizal Kapri,Murni Halim,Arbakariya B Ariff
Determination of a microbial strain for the joining into sustenance items requires both in vitro and in vivo assessment. A newly isolated bacteriocin-like inhibitory substance (BLIS) producing lactic acid bacterium, Lactococcus lactis Gh1, was isolated from a traditional flavour enhancer and evaluated in vitro for its potential applications in the food industry. Results from this study showed that
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Lactobacillus plantarum-Mediated Regulation of Dietary Aluminum Induces Changes in the Human Gut Microbiota: an In Vitro Colonic Fermentation Study. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-26 Leilei Yu,Hui Duan,Lee Kellingray,Shi Cen,Fengwei Tian,Jianxin Zhao,Hao Zhang,Gwénaëlle Le Gall,Melinda J Mayer,Qixiao Zhai,Wei Chen,Arjan Narbad
The gut microbiota has been identified as a target of toxic metals and a potentially crucial mediator of the bioavailability and toxicity of these metals. In this study, we show that aluminum (Al) exposure, even at low dose, affected the growth of representative strains from the human intestine via pure culture experiments. In vitro, Lactobacillus plantarum CCFM639 could bind Al on its cell surface
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Compatibility, Cytotoxicity, and Gastrointestinal Tenacity of Bacteriocin-Producing Bacteria Selected for a Consortium Probiotic Formulation to Be Used in Livestock Feed. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-25 Mégane Eveno,Patricia Savard,Yanath Belguesmia,Laurent Bazinet,Frédérique Gancel,Djamel Drider,Ismail Fliss
Bacteriocin-producing Escherichia coli ICVB442, E. coli ICVB443, Enterococcus faecalis ICVB497, E. faecalis ICVB501, and Pediococcus pentosaceus ICVB491 strains were examined for their pathogenic risks and compatibility and hence suitability as consortium probiotic bacteria. Except for E. coli ICVB442, all were inclined to form biofilm. All were gelatinase-negative, sensitive to most of the antibiotics
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Effect of Dermaseptin S4 on C. albicans Growth and EAP1 and HWP1 Gene Expression. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-21 Johan Samot,Mahmoud Rouabhia
Increasing resistance and changes in the spectrum of Candida infections have generated considerable interest in the development of new antifungal molecules. The use of antimicrobial peptides (AMPs) appears to be a promising approach. Frog skin AMPs (such as dermaseptins) have shown antimicrobial activity against several pathogens. In this study, we aimed to test the antimicrobial efficacy of dermaseptin
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Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-14 Yongqing Liu,Tengfei Shen,Liangliang Chen,Jiangfei Zhou,Chen Wang
Antimicrobial peptides (AMPs) have gained interesting as a new type of antimicrobial agent. The cathelicidin-derived antimicrobial peptide PMAP-23 has broad-spectrum antibacterial activity, and to improve its antimicrobial activity, we used amino acid substitution at position 5 or 19 of PMAP-23 to design three analogs, named PMAP-23R (Leu5--Arg), PMAP-23I (Thr19--Ile), and PMAP-23RI (Leu5--Arg and
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Recombinant Lactococcus Lactis Displaying Omp31 Antigen of Brucella melitensis Can Induce an Immunogenic Response in BALB/c Mice. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-13 Hoda Shirdast,Fatemeh Ebrahimzadeh,Amir Hossein Taromchi,Yousef Mortazavi,Abdolreza Esmaeilzadeh,Mohammad Hadi Sekhavati,Keivan Nedaei,Esmat Mirabzadeh
Since Brucella infection mostly occurs through the mucosal surfaces, immune response induced by vaccine that is delivered by a way of mucosal route can be drastically enhanced to control the brucellosis. Omp31is the major outer membrane protein of Brucella, and is considered as a protective antigen against Brucella infection. Accordingly, Lactococcus lactis has been used as an antigen-delivering vector
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Role of Probiotics in Oral Health Maintenance Among Patients Undergoing Fixed Orthodontic Therapy: a Systematic Review of Randomized Controlled Clinical Trials. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-07-04 Francesca Katherine Pietri,P Emile Rossouw,Fawad Javed,Dimitrios Michelogiannakis
The aim was to assess the role of probiotics in oral health maintenance among patients undergoing fixed orthodontic therapy (OT). An unrestricted search of indexed databases was performed until April 2020 using the following Mesh-terms: (1) probiotic and (2) orthodontic. Randomized controlled clinical trials (RCTs) evaluating the influence of probiotic therapy (PT) towards oral health maintenance/improvement
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Safety Evaluation and In vivo Strain-Specific Functionality of Bacillus Strains Isolated from Korean Traditional Fermented Foods. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-30 Haryung Park,Myungki Lee,Dahye Jeong,Soyoung Park,Yosep Ji,Svetoslav D Todorov,Wilhelm H Holzapfel
Unveiling and understanding differences in physiological features below the species level may serve as an essential fast-screening tool for selecting strains that can promote a specific probiotic effect. To study the intra-species diversity of Bacillus, a genus with a wide range of enzyme activities and specificity, 190 Bacillus strains were isolated from traditional Korean fermented food products
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Modeling the Ethanol Tolerance of the Probiotic Yeast Saccharomyces cerevisiae var. boulardii CNCM I-745 for its Possible Use in a Functional Beer. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-29 G Yedid Ramírez-Cota,E Oliver López-Villegas,Antonio R Jiménez-Aparicio,Humberto Hernández-Sánchez
Saccharomyces yeasts are able to ferment simple sugars to generate levels of ethanol that are toxic to other yeasts and bacteria. The tolerance to ethanol of different yeasts depends also on the incubation temperature. In this study, the ethanol stress responses of S. cerevisiae and the probiotic yeast S. boulardii CNCM I-745 were evaluated at two temperatures. The growth kinetics parameters were obtained
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Inhibitory Effect of Lipoteichoic Acid Derived from Three Lactobacilli on Flagellin-Induced IL-8 Production in Porcine Peripheral Blood Mononuclear Cells. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-30 Bong Sun Kim,Cheol-Heui Yun,Seung Hyun Han,Ki-Duk Song,Seok-Seong Kang
Probiotics in livestock feed supplements are considered to be an alternative to antibiotics. However, effector molecules responsible for the beneficial roles of probiotics in pigs are in general not well known. Thus, this study demonstrated that a well-known virulence factor, flagellin of Salmonella typhimurium, significantly induced IL-8 production in porcine peripheral blood mononuclear cells, whereas
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Effect of Multi-strain Probiotic Formulation on Students Facing Examination Stress: a Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-29 Rajesh Venkataraman,Ratna Sudha Madempudi,Jayanthi Neelamraju,Jayesh J Ahire,H R Vinay,Anila Lal,Glory Thomas,Stephy Stephen
In this placebo-controlled, double-blind clinical trial, we have investigated the effect of multi-strain probiotic (Bacillus coagulans Unique IS2, Lactobacillus rhamnosus UBLR58, Bifidobacterium lactis UBBLa70, Lactobacillus plantarum UBLP40 (each of 2 billion CFU); Bifidobacterium breve UBBr01, Bifidobacterium infantis UBBI01 (each of 1 billion CFU)) capsule with glutamine (250 mg) on students facing
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Tapioca Starch Modulates Cellular Events in Oral Probiotic Streptococcus salivarius Strains. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-29 Rafig Gurbanov,Hazel Karadağ,Sevinç Karaçam,Gizem Samgane
Considering the implications of microbiota in health, scientists are in search of microbiota-oriented strategies for the effective prevention and/or treatment of a wide variety of serious diseases. A microbiota comprises diverse microorganisms with either probiotic or pathogenic properties. The fermentation of prebiotic carbohydrates by probiotic bacteria can affect host metabolism. Therefore, understanding
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Isolation, Identification, and Screening of Lactic Acid Bacteria with Probiotic Potential in Silage of Different Species of Forage Plants, Cocoa Beans, and Artisanal Salami. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-29 Eliana Dos Santos Leandro,Verônica Cortez Ginani,Ernandes Rodrigues de Alencar,Odilon Gomes Pereira,Ester Cardoso Paes Rose,Helson Mário Martins do Vale,Riccardo Pratesi,Mariana Machado Hecht,Marilia Hermes Cavalcanti,Caroline Stéfany Oliveira Tavares
The objective of this study was to isolate and characterize lactic acid bacteria with probiotic potential in silages of different species of forage plants, cocoa beans, and artisanal salami. The obtained isolates were submitted to the following evaluations: (i) screening for tolerance to pH 2 and bile salts, (ii) genotypic identification of isolates, (iii) survival in simulated gastric and pancreatic
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Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-24 Monika Kumherová,Kristina Veselá,Michaela Kosová,Jaromír Mašata,Šárka Horáčková,Jan Šmidrkal
Lactobacilli in the vaginal tract are essential to protect against microbial infections. We therefore focused on isolating vaginal lactobacilli from pregnant women and testing their functional properties. Lactobacilli were isolated from 50 vaginal swabs and the purified isolates were identified by MALDI-TOF MS. Functional properties (antimicrobial activity, organic acids and hydrogen peroxide production
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Probiotic Properties of New Lactobacillus Strains Intended to Be Used as Feed Additives for Monogastric Animals. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-23 Katarzyna Śliżewska,Agnieszka Chlebicz-Wójcik,Adriana Nowak
The study aimed to evaluate the safety and probiotic properties of selected Lactobacillus strains, which are intended to be fed to monogastric animals. The Lactobacillus spp. appeared to be safe since they did not degrade mucus and did not exhibit β-haemolysis. Moreover, the survival of Caco-2 cells in the presence of metabolites of the selected strains was high, which also indicated their safety.
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Effects of Pretreatments on Patulin Removal from Apple Juices Using Lactobacilli: Binding Stability in Simulated Gastrointestinal Condition and Modeling. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-22 Alaleh Zoghi,Kianoush Khosravi Darani,Azita Hekmatdoost
Recently, researchers have reported the presence of patulin as a mycotoxin in commercial apple products, especially apple juices. The aim of this study was to assess adsorption of patulin from artificially contaminated apple juice using two lactic acid bacteria (LAB) strains of Lactobacillus acidophilus ATCC 4356 and Lactobacillus plantarum ATCC 8014. Furthermore, effects of five physical and chemical
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Heterologous Expression of the Leuconostoc Bacteriocin Leucocin C in Probiotic Yeast Saccharomyces boulardii. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-21 Ran Li,Xing Wan,Timo M Takala,Per E J Saris
The yeast Saccharomyces boulardii is well known for its probiotic effects such as treating or preventing gastrointestinal diseases. Due to its ability to survive in stomach and intestine, S. boulardii could be applied as a vehicle for producing and delivering bioactive substances of interest to human gut. In this study, we cloned the gene lecC encoding the antilisterial peptide leucocin C from lactic
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Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing. Probiotics Antimicrob. Proteins (IF 3.533) Pub Date : 2020-06-17 Deon P Neveling,Leon M T Dicks
Pathogens develop resistance to antibiotics at a rate much faster than the discovery of new antimicrobial compounds. Reports of multidrug-resistant bacteria isolated from broilers, and the possibility that these strains may spread diseases amongst humans, prompted many European countries to ban the inclusion of antibiotics in feed. Probiotics added to broiler feed controlled a number of bacterial infections
更新日期:2020-06-18