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The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia Virulence (IF 5.2) Pub Date : 2024-03-11 Minjia Chen, Xiuqin Cao, Ronghui Zheng, Haixia Chen, Ruixia He, Hao Zhou, Zhiwei Yang
Legionella pneumophila (L. pneumophila) is a prevalent pathogenic bacterium responsible for significant global health concerns. Nonetheless, the precise pathogenic mechanisms of L. pneumophila have...
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Sensitive bioluminescence imaging of cryptococcosis in Galleria mellonella improves antifungal screening under in vivo conditions Virulence (IF 5.2) Pub Date : 2024-03-13 Eliane Vanhoffelen, Lori Vermoesen, Lauren Michiels, Katrien Lagrou, Agustin Reséndiz-Sharpe, Greetje Vande Velde
Cryptococcus neoformans is an environmental yeast that primarily affects immunocompromised individuals, causing respiratory infections and life-threatening meningoencephalitis. Treatment is complic...
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Autophagy-related protein PlATG2 regulates the vegetative growth, sporangial cleavage, autophagosome formation, and pathogenicity of peronophythora litchii Virulence (IF 5.2) Pub Date : 2024-03-04 Lin Lv, Chengdong Yang, Xue Zhang, Taixu Chen, Manfei Luo, Ge Yu, Qinghe Chen
Autophagy is an intracellular degradation process that is important for the development and pathogenicity of phytopathogenic fungi and for the defence response of plants. However, the molecular mec...
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Sneaky tactics: Ingenious immune evasion mechanisms of Bartonella Virulence (IF 5.2) Pub Date : 2024-03-05 Yixuan Xi, Xinru Li, Lu Liu, Feichen Xiu, Xinchao Yi, Hongliang Chen, Xiaoxing You
Gram-negative Bartonella species are facultative intracellular bacteria that can survive in the harsh intracellular milieu of host cells. They have evolved strategies to evade detection and degrada...
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Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period Virulence (IF 5.2) Pub Date : 2024-02-21 Célia Regina Malveste Ito, Mônica Oliveira Santos, Marcos de Oliveira Cunha, Kelliane Martins de Araújo, Guilherme Rocha Lino de Souza, Geovana Sôffa Rézio, Pollyanna Neta de Brito, Alana Parreira Costa Rezende, Jakeline Godinho Fonseca, Isabela Jubé Wastowski, José Daniel Gonçalves Vieira, Melissa Ameloti Gomes Avelino, Lilian Carla Carneiro
Rhinovirus causes respiratory tract infections in children and is found in co-infections. The objective of this research was to study the clinical profile of rhinovirus infection and co-infection i...
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Microbiome analysis reveals the inducing effect of Pseudomonas on prostatic hyperplasia via activating NF-κB signalling Virulence (IF 5.2) Pub Date : 2024-02-20 Jiaren Li, Youyou Li, Liang Zhou, Hongming Li, Tengfei Wan, Jin Tang, Lei Zhou, Hui Xie, Long Wang
Benign prostatic hyperplasia (BPH) is a prevalent disease among middle-aged and elderly males, but its pathogenesis remains unclear. Dysbiosis of the microbiome is increasingly recognized as a sign...
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Pathogenicity and virulence of Yersinia Virulence (IF 5.2) Pub Date : 2024-02-22 Jarett A. Seabaugh, Deborah M. Anderson
The genus Yersinia includes human, animal, insect, and plant pathogens as well as many symbionts and harmless bacteria. Within this genus are Yersinia enterocolitica and the Yersinia pseudotubercul...
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Letter to the editor (response to Vajro and colleagues) Virulence (IF 5.2) Pub Date : 2024-02-22 Roger J. Grand
Published in Virulence (Vol. 15, No. 1, 2024)
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Acute hepatitis of unknown origin in children: Should we move the discussion from a purely infectious origin also to other plausible causes? Virulence (IF 5.2) Pub Date : 2024-02-22 Pietro Vajro, Claudia Mandato, Björn Fischler
Published in Virulence (Vol. 15, No. 1, 2024)
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Intranasal B5 promotes mucosal defence against Actinobacillus pleuropneumoniae via ameliorating early immunosuppression Virulence (IF 5.2) Pub Date : 2024-02-20 Jingsheng Huang, Weichao Kang, Dandan Yi, Shuxin Zhu, Yifei Xiang, Chengzhi Liu, Han Li, Dejia Dai, Jieyu Su, Jiakang He, Zhengmin Liang
Actinobacillus pleuropneumoniae (APP) is an important pathogen of the porcine respiratory disease complex, which leads to huge economic losses worldwide. We previously demonstrated that Pichia past...
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Escherichia coli and HPV16 coinfection may contribute to the development of cervical cancer Virulence (IF 5.2) Pub Date : 2024-02-21 Qin Zou, Yingying Wu, ShuaiShuai Zhang, Shu Li, Siyue Li, Yan Su, Lei Zhang, Qian Li, Hua Zou, Xinyuan Zhang, Teng Wang, Shuang Liang, Jun Yang, Chunli Li
Persistent human papillomavirus HPV infection is a necessary but insufficient condition for cervical cancer. Microorganisms are crucial environmental factors in cancers susceptibility and progressi...
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Genomic island-encoded regulatory proteins in enterohemorrhagic Escherichia coli O157:H7 Virulence (IF 5.2) Pub Date : 2024-02-15 Fang Wang, Hongmin Sun, Chenbo Kang, Jun Yan, Jingnan Chen, Xuequan Feng, Bin Yang
Enterohemorrhagic Escherichia coli (EHEC) is an important zoonotic pathogen that is a major cause of foodborne diseases in most developed and developing countries and can cause uncomplicated diarrh...
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Characterising phagocytes and measuring phagocytosis from live Galleria mellonella larvae Virulence (IF 5.2) Pub Date : 2024-02-15 Jennie S. Campbell, James C. Pearce, Attila Bebes, Arnab Pradhan, Raif Yuecel, Alistair J P Brown, James G. Wakefield
Over the last 20 years, the larva of the greater waxmoth, Galleria mellonella, has rapidly increased in popularity as an in vivo mammalian replacement model organism for the study of human pathogen...
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Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19 Virulence (IF 5.2) Pub Date : 2024-02-16 Natalie M. Kirk, Yuying Liang, Hinh Ly
Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of th...
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Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition of nucleic acid synthesis, mRNA splicing, and protein stability Virulence (IF 5.2) Pub Date : 2024-02-06 Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang
Influenza A virus (IAV) poses a threat to patients receiving immunosuppressive medications since they are more susceptible to infection with severe symptoms, and even death. Understanding the direc...
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Gut-brain axis interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer’s disease Virulence (IF 5.2) Pub Date : 2024-02-04 Meenakshi Kandpal, Budhadev Baral, Nidhi Varshney, Ajay Kumar Jain, Debi Chatterji, Ajay Kumar Meena, Rajan Kumar Pandey, Hem Chandra Jha
Helicobacter pylori is a pathogenic bacterium that causes gastritis and gastric carcinoma. Besides gastric complications its potential link with gut-brain axis disruption and neurological disorders...
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HylS’, a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b Virulence (IF 5.2) Pub Date : 2024-02-04 Jiajia Xu, Long Chen, Siqi Pang, Qiuhong Zhang, Simin Deng, Jiaqi Zhu, Xiabing Chen, Paul R Langford, Qi Huang, Rui Zhou, Lu Li
Pathogenic bacteria have evolved many strategies to evade surveillance and attack by complements. Streptococcus suis is an important zoonotic pathogen that infects humans and pigs. Hyaluronidase (H...
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Streptococcal arginine deiminase system defences macrophage bactericidal effect mediated by XRE family protein XtrSs Virulence (IF 5.2) Pub Date : 2024-02-02 Yumin Zhang, Song Liang, Shidan Zhang, Qiankun Bai, Lei Dai, Jinxiu Wang, Huochun Yao, Wei Zhang, Guangjin Liu
The arginine deiminase system (ADS) has been identified in various bacteria and functions to supplement energy production and enhance biological adaptability. The current understanding of the regul...
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RNA-Seq and miRNA-Seq data from Epstein-Barr virus-infected tree shrews reveal a ceRNA network contributing to immune microenvironment regulation Virulence (IF 5.2) Pub Date : 2024-01-29 Wei Xia, Nan Shi, Chaoqian Li, Anzhou Tang
Epstein-Barr virus (EBV) infection in humans is ubiquitous and associated with various diseases. Remodeling of the immune microenvironment is the primary cause of EBV infection and pathogenesis; ho...
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UvVelC is important for conidiation and pathogenicity in the rice false smut pathogen Ustilaginoidea virens Virulence (IF 5.2) Pub Date : 2024-01-19 Mina Yu, Tianqiao Song, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Wende Liu, Yongfeng Liu
Rice false smut disease is one of the most significant rice diseases worldwide. Ustilaginoidea virens is the causative agent of this disease. Although several developmental and pathogenic genes hav...
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Nervous necrosis virus induced vacuolization is a Rab5- and actin-dependent process Virulence (IF 5.2) Pub Date : 2024-01-17 Jiaxin Liu, Liqun Wang, Xinyue Zhang, Shaowen Wang, Qiwei Qin
Cytoplasmic vacuolization is commonly induced by bacteria and viruses, reflecting the complex interactions between pathogens and the host. However, their characteristics and formation remain unclea...
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Streptococcus suis subtilisin-like serine proteases SspA-1 and SspA-2 interplay with complement C3a and C5a to facilitate bacterial immune evasion and infection Virulence (IF 5.2) Pub Date : 2024-01-16 Simin Deng, Junhui Liao, Haojie Li, Jiali Xu, Jingyan Fan, Jing Xia, Jing Wang, Lei Lei, Mianmian Chen, Yue Han, Ruidong Zhai, Chang Zhou, Rui Zhou, Changyong Cheng, Houhui Song
Streptococcus suis (S. suis), a significant zoonotic bacterial pathogen impacting swine and human, is associated with severe systemic diseases such as streptococcal toxic shock-like syndrome, menin...
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Ixchiq (VLA1553): The first FDA-approved vaccine to prevent disease caused by Chikungunya virus infection Virulence (IF 5.2) Pub Date : 2024-01-13 Hinh Ly
Published in Virulence (Vol. 15, No. 1, 2024)
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The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review Virulence (IF 5.2) Pub Date : 2024-01-09 Xiaolong Lu, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu
Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negat...
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TLR2 regulates Moraxella catarrhalis adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses Virulence (IF 5.2) Pub Date : 2024-01-03 Rui Ding, Jinhan Yu, Weixin Ke, Lijun Du, Guixue Cheng, Siqi Hu, Yingchun Xu, Yali Liu
Moraxella catarrhalis is a major cause of chronic obstructive pulmonary disease. Toll-like receptor 2 (TLR2) plays an important role in the inflammatory response in host respiratory epithelial cell...
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Synergistic effects of putative Ca2+-binding sites of calmodulin in fungal development, temperature stress and virulence of Aspergillus fumigatus Virulence (IF 5.2) Pub Date : 2023-12-12 Xingyue Li, Ruoyun Feng, Pan Luo, Yuanwei Zhang, Ling Lu
In pathogenic fungi, calcium-calmodulin-dependent serine-threonine-specific phosphatase calcineurin is involved in morphogenesis and virulence. Therefore, calcineurin and its tightly related protei...
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Pathogenicity and virulence of Acinetobacter baumannii: Factors contributing to the fitness in healthcare settings and the infected host Virulence (IF 5.2) Pub Date : 2023-12-06 Massimiliano Lucidi, Daniela Visaggio, Antonella Migliaccio, Giulia Capecchi, Paolo Visca, Francesco Imperi, Raffaele Zarrilli
Acinetobacter baumannii is a common cause of healthcare-associated infections and hospital outbreaks, particularly in intensive care units. Much of the success of A. baumannii relies on its genomic...
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Unraveling the interplay between unicellular parasites and bacterial biofilms: Implications for disease persistence and antibiotic resistance Virulence (IF 5.2) Pub Date : 2023-12-06 Eva Zanditenas, Serge Ankri
Bacterial biofilms have attracted significant attention due to their involvement in persistent infections, food and water contamination, and infrastructure corrosion. This review delves into the in...
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Highly pathogenic avian influenza H5N1 virus infection of companion animals Virulence (IF 5.2) Pub Date : 2023-12-08 Hinh Ly
Published in Virulence (Vol. 15, No. 1, 2024)
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The host protein CALCOCO2 interacts with bovine viral diarrhoea virus Npro, inhibiting type I interferon production and thereby promoting viral replication Virulence (IF 5.2) Pub Date : 2023-12-04 Song Wang, Ran Wei, Xiaomei Ma, Jin Guo, Muhammad Aizaz, Fangxu Li, Jun Wang, Hongmei Wang, Hongbin He
Bovine viral diarrhoea-mucosal disease caused by bovine viral diarrhoea virus (BVDV) is a major infectious disease that affects the cattle industry. The nonstructural protein Npro of BVDV antagoniz...
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Dry eye disease caused by viral infection: Past, present and future Virulence (IF 5.2) Pub Date : 2023-12-04 Min Wu, Cuilian Sun, Qin Shi, Yalu Luo, Ziyu Wang, Jianxiang Wang, Yun Qin, Weihang Cui, Chufeng Yan, Huangyi Dai, Zhiyang Wang, Jia Zeng, Yamei Zhou, Manhui Zhu, Xiaojuan Liu
Following viral infection, the innate immune system senses viral products, such as viral nucleic acids, to activate innate defence pathways, leading to inflammation and apoptosis, control of cell p...
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LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells Virulence (IF 5.2) Pub Date : 2023-11-29 Weiting Mao, Zhichao Wang, Siting Wen, Yan Lin, Jiayun Gu, Ju Sun, Huan Wang, Qi Cao, Yindi Xu, Xiaojuan Xu, Xuwang Cai
Glaesserella parasuis is an early colonizer of the swine upper respiratory tract and can break through the respiratory barrier for further invasion. However, the mechanisms underlying G. parasuis i...
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Endopeptidase O promotes Streptococcus suis immune evasion by cleaving the host- defence peptide cathelicidins Virulence (IF 5.2) Pub Date : 2023-11-27 Mingjie Jin, Siyu Liang, Jing Wang, Huihui Zhang, Yueling Zhang, Wanjiang Zhang, Siguo Liu, Fang Xie
Streptococcus suis is a zoonotic Gram-positive bacterium that causes invasive infections such as sepsis and meningitis, threatening public health worldwide. For successful establishment of infectio...
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Lambda-free light chain: A serum marker of dengue disease via NS3 protease-mediated antibody cleavage Virulence (IF 5.2) Pub Date : 2023-11-20 Sheng-Hsuan Wang, Bai-Jiun Kuo, Tzu-Chuan Ho, Shu-Wen Wan, Ko-Lun Yen, Po-Hui Huang, Oscar Guey Chuen Perng, Po-Lin Chen, Yu-Wen Chien, Yu-Chih Lo
Dengue poses a significant global public health threat, with diverse clinical manifestations due to complex interactions between the host and the pathogen. Recent reports have highlighted elevated ...
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Pathogenicity and virulence of Shigella sonnei: A highly drug-resistant pathogen of increasing prevalence Virulence (IF 5.2) Pub Date : 2023-11-23 Xosé M. Matanza, Abigail Clements
Shigella spp. are the causative agent of shigellosis (or bacillary dysentery), a diarrhoeal disease characterized for the bacterial invasion of gut epithelial cells. Among the 4 species included in...
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One-step preparation of a self-assembled bioconjugate nanovaccine against Brucella Virulence (IF 5.2) Pub Date : 2023-11-19 Jing Huang, Yan Guo, Shujuan Yu, Dongshu Wang, Shulei Li, Jun Wu, Peng Sun, Li Zhu, Hengliang Wang, Chao Pan
Brucellosis, caused by Brucella, is a severe zoonosis, and the current Brucella live attenuated vaccine cannot be used in humans due to major safety risks. Although polysaccharide antigens can be u...
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The ever-expanding diversity and complexity of the Arenaviridae family Virulence (IF 5.2) Pub Date : 2023-11-15 Hinh Ly
Published in Virulence (Vol. 14, No. 1, 2023)
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Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes Virulence (IF 5.2) Pub Date : 2023-11-16 Fang Sun, Guanglin Lei, Chongyu Tian, Zhifang Bai, Changqing Bai, Yufeng Li, Zhuoya Deng, Hao Yang, Cong Li, Zhongpeng Zhao, Yan Niu, Penghui Yang
Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants and children. Currently, no approved HMPV vaccine is available. We developed a novel recombinant inf...
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The twin-arginine translocation system is vital for cell adhesion and uptake of iron in the cystic fibrosis pathogen Achromobacter xylosoxidans Virulence (IF 5.2) Pub Date : 2023-11-16 S. M. Hossein Khademi, Cecilia Sahl, Lotta Happonen, Åke Forsberg, Lisa I. Påhlman
Achromobacter xylosoxidans is an emerging pathogen that causes airway infections in patients with cystic fibrosis. Knowledge of virulence factors and protein secretion systems in this bacterium is ...
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Pathogenicity and virulence of human respiratory syncytial virus: Multifunctional nonstructural proteins NS1 and NS2 Virulence (IF 5.2) Pub Date : 2023-11-15 Trudy N. Merritt, Jingjing Pei, Daisy W. Leung
Human respiratory syncytial virus (hRSV) is a major cause of acute lower respiratory tract infections in children under the age of two as well as in the elderly and immunocompromised worldwide. Des...
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Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages Virulence (IF 5.2) Pub Date : 2023-11-15 Lucas José Barone, Nancy Patricia Cardoso, Florencia Celeste Mansilla, Mariángeles Castillo, Alejandra Victoria Capozzo
Macrophages are important cells of the innate immunity that play a major role in Bovine Viral Diarrhea Virus (BVDV) pathogenesis. Macrophages are not a homogenous population; they exist in differen...
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Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition Virulence (IF 5.2) Pub Date : 2023-11-15 Hong Zhang, Tao Zhu, Wenchun Xu, Bichen Liu, Kaifeng Wu, Yibing Yin, Xuemei Zhang
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear. In this study, we focused...
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Mycoplasma synoviae induce spleen tissue damage and inflammatory response of chicken through oxidative stress and apoptosis Virulence (IF 5.2) Pub Date : 2023-11-14 Lemiao Zhong, Chunlin Wu, Lvyan Liao, Yijian Wu
Mycoplasma synovium (MS) is a prominent avian pathogen known to elicit robust inflammatory responses in birds while evading immune detection, often leading to chronic infection and immune compromis...
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A Drosophila melanogaster model shows that fast growing Metarhizium species are the deadliest despite eliciting a strong immune response Virulence (IF 5.2) Pub Date : 2023-11-08 Jonathan B. Wang, Hsiao-Ling Lu, Huiyu Sheng, Raymond J St. Leger
We used Drosophila melanogaster to investigate how differences between Metarhizium species in growth rate and mechanisms of pathogenesis influence the outcome of infection. We found that the most r...
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Noninvasive diagnosis of significant liver inflammation in patients with chronic hepatitis B in the indeterminate phase Virulence (IF 5.2) Pub Date : 2023-11-08 Jie Zhan, Jian Wang, Zhiyi Zhang, Ruifei Xue, Suling Jiang, Jiacheng Liu, Yilin Liu, Li Zhu, Juan Xia, Xiaomin Yan, Weimao Ding, Chuanwu Zhu, Yuanwang Qiu, Jie Li, Rui Huang, Chao Wu
The presence of significant liver inflammation is an important indication for antiviral treatment in patients with chronic hepatitis B (CHB) in the indeterminate phase. We aimed to establish a non-...
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Prevalence and analysis of acquired and transmitted integrase strand transfer inhibitor-associated HIV-1 drug resistance in Chongqing, China Virulence (IF 5.2) Pub Date : 2023-11-09 Huizheng Zhang, Ping Wu, Jungang Li, Mei Li
In this study, we examined the occurrence of acquired and transmitted drug resistance to integrase strand transfer inhibitor (INSTI) in HIV-1 strains in Chongqing (China) for guiding for the routin...
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Microbiome diversity is a modifiable virulence factor for cryptosporidiosis Virulence (IF 5.2) Pub Date : 2023-11-10 Georgina. R. Hurle, Julii Brainard, Kevin. M. Tyler
Cryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis i...
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Pathogenicity and virulence of henipaviruses Virulence (IF 5.2) Pub Date : 2023-11-10 Benjamin Kaza, Hector C. Aguilar
Paramyxoviruses are a family of single-stranded negative-sense RNA viruses, many of which are responsible for a range of respiratory and neurological diseases in humans and animals. Among the most ...
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Analysis of the virulence, infection process, and extracellular enzyme activities of Aspergillus nomius against the Asian corn borer, Ostrinia furnacalis guenée (Lepidoptera: Crambidae) Virulence (IF 5.2) Pub Date : 2023-11-09 Xiaowu Wang, Xinhua Ding, Zihan Yuan, Zunzun Jia, Kaiyun Fu, Faqiang Zhan, Wenchao Guo, Liuyan Zhou, Haiqiang Li, Jinping Dai, Zhifang Wang, Yuqing Xie, Xinping Yang
The control of Ostrinia furnacalis, a major pest of maize in Xinjiang, is challenging owing to the occurrence of resistant individuals. Entomopathogenic fungi (EPF) are natural insect regulators us...
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Pathogenicity and virulence of Francisella tularensis Virulence (IF 5.2) Pub Date : 2023-11-08 Manon Degabriel, Stanimira Valeva, Sandrine Boisset, Thomas Henry
Tularaemia is a zoonotic disease caused by the Gram-negative bacterium, Francisella tularensis. Depending on its entry route into the organism, F. tularensis causes different diseases, ranging from...
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A novel quorum sensing regulator LuxT contributes to the virulence of Vibrio cholerae Virulence (IF 5.2) Pub Date : 2023-10-31 Yuehua Li, Junxiang Yan, Jinghao Li, Xinke Xue, Ying Wang, Boyang Cao
Vibrio cholerae is a waterborne bacterium that primarily infects the human intestine and causes cholera fatality. Quorum sensing (QS) negatively regulates the expression of V. cholerae virulence ge...
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Potential of phage depolymerase for the treatment of bacterial biofilms Virulence (IF 5.2) Pub Date : 2023-10-31 Zhimin Guo, Mengmeng Liu, Dan Zhang
Resistance of bacteria to antibiotics is a major concern in medicine and veterinary science. The bacterial biofilm structures not only prevent the penetration of drugs into cells within the biofilm...
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Uncovering the hidden threat: The widespread presence of chromosome-borne accessory genetic elements and novel antibiotic resistance genetic environments in Aeromonas Virulence (IF 5.2) Pub Date : 2023-10-27 Fangzhou Chen, Ting Yu, Zhe Yin, Peng Wang, Xiuhui Lu, Jiaqi He, Yali Zheng, Dongsheng Zhou, Bo Gao, Kai Mu
The emergence of antibiotic-resistant Aeromonas strains in clinical settings has presented an escalating burden on human and public health. The dissemination of antibiotic resistance in Aeromonas i...
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Amphibian Hymenochirus boettgeri as an experimental model for infection studies with the chytrid fungus Batrachochytrium dendrobatidis Virulence (IF 5.2) Pub Date : 2023-10-27 Tamilie Carvalho, Catherine Si, Rebecca A. Clemons, Evelyn Faust, Timothy Y. James
Model organisms are crucial in research as they can provide key insights applicable to other species. This study proposes the use of the amphibian species Hymenochirus boettgeri, widely available t...
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A novel Galleria mellonella experimental model for zoonotic pathogen Brucella Virulence (IF 5.2) Pub Date : 2023-10-23 Shuyi Wang, Ying Yin, Xiaodong Zai, Yanfei Gu, Fengyu Guo, Fangze Shao, Yue Zhang, Yaohui Li, Ruihua Li, Jun Zhang, Junjie Xu, Wei Chen
Brucellosis is a major threat to public health and animal husbandry. Several in vivo vertebrate models, such as mice, guinea pigs, and nonhuman primates, have been used to study Brucella pathogenes...
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Organelles are miscommunicating: Membrane contact sites getting hijacked by pathogens Virulence (IF 5.2) Pub Date : 2023-10-20 Pratyashaa Paul, Bhavana Tiwari
Membrane Contact Sites (MCS) are areas of close apposition of organelles that serve as hotspots for crosstalk and direct transport of lipids, proteins and metabolites. Contact sites play an importa...
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Streptococcus pyogenes emm98.1 variants activate inflammatory caspases in human neutrophils Virulence (IF 5.2) Pub Date : 2023-10-13 Jonathan G. Williams, Ronald Sluyter, Martina L. Sanderson-Smith
The human pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for invasive disease characterized by inflammation and tissue destruction. Inflammatory symptoms of invasive di...
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Influenza enhances host susceptibility to non-pulmonary invasive Streptococcus pyogenes infections Virulence (IF 5.2) Pub Date : 2023-10-09 Andrea L. Herrera, Rashaun Potts, Victor C. Huber, Michael S. Chaussee
Streptococcus pyogenes (group A streptococcus; GAS) causes a variety of invasive diseases (iGAS) such as bacteremia, toxic shock syndrome, and pneumonia, which are associated with high mortality de...