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Immunoproteomics characterization of Leishmania panamensis proteins for potential clinical diagnosis of mucosal leishmaniasis Parasite Immunol. (IF 2.054) Pub Date : 2021-01-23 A Caraballo‐Guzmán; JD Ospina‐Villa; APM Cuesta‐Caicedo; MM Sánchez‐Jiménez
Diagnosis of leishmaniasis based on antibodies detection represents a challenge due to cross‐reaction of sera with other infectious agents, which co‐exist in endemic areas of Leishmania sp., especially patients with Trypanosoma cruzi. This work is aimed at searching for immunogenic proteins in sera from patients with cutaneous and mucosal leishmaniasis that may be potential candidates for the development
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Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L. infantum infection Parasite Immunol. (IF 2.054) Pub Date : 2021-01-23 Lívia Mendes Carvalho; Rory Cristiane Fortes de Brito; Miriã Rodrigues Gusmão; Rodrigo Dian de Oliveira Aguiar‐Soares; Alexandre Barbosa Reis; Bruno Mendes Roatt
Syrian hamsters (Mesocricetus auratus) are largely used as a model for infectious diseases because it is very susceptible to several pathogens, including Leishmania spp. parasites. However, the research community faces limitations in its use due to the lack of immunological reagents and tools to study the immune system in this model. In this context, we proposed the validation of some important commercially
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Neutrophils from patients with the cardiac clinical form of Chagas disease release less NETs than neutrophils from healthy individuals Parasite Immunol. (IF 2.054) Pub Date : 2021-01-15 Valéria Duarte de Almeida; Eduardo B. L. da Câmara; Marcelo Augusto A. Castro; Suyane Maria P. Pimenta; Bruna Luiza T. Hernandes; Dayane Carla C. Paiva; Cléber M. Andrade; Ellany G. C. do Nascimento; Thales Allyrio A. M. Fernandes; Micássio F. Andrade
Chagas disease (CD) is a global health concern with approximately 12 000 deaths per year worldwide. In the chronic phase, about 30% of patients develop the cardiac clinical form, which presents symptoms associated with the presence of inflammatory cells in the cardiac tissue. Neutrophils are inflammatory cells able to modulate the chronic immune response against pathogens. These cells are capable of
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Association of previous schistosome infection with fatty liver and coronary heart disease: a cross‐sectional study in China Parasite Immunol. (IF 2.054) Pub Date : 2021-01-17 Zhuo‐qun Zou; Mei Liu; Huai‐qin Zhong; Guo‐yue Guan
More than 11 million people were estimated to have been infected by Schistosoma japonicum in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI).
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Protein deficiency during Trichinella spiralis infection impairs lung immunity against newborn larvae Parasite Immunol. (IF 2.054) Pub Date : 2021-01-12 Cecilia C. Vila; María P. Saracino; Tomás Lombardo; Guido H. Falduto; Mariángeles Díaz; Marcela A. Calcagno; Anabel N. Pallaro; Pablo C. Baldi
To analyze the effects of a protein deficient (PD) diet on antibody‐dependent cell‐mediated cytotoxicity (ADCC) in vitro against newborn larvae (NBL) of Trichinella spiralis in the lungs of infected rats.
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Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle Parasite Immunol. (IF 2.054) Pub Date : 2020-12-26 Jennifer D. Helble; Julie E. McCarthy; Linden T. Hu
The bacterial pathogen Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to humans through an Ixodes tick vector. B. burgdorferi is able to survive in both mammalian and tick hosts through careful modulation of its gene expression. This allows B. burgdorferi to adapt to the environmental and nutritional changes that occur when it is transmitted between the two hosts. Distinct
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Tick hypersensitivity and human tick‐borne diseases Parasite Immunol. (IF 2.054) Pub Date : 2021-01-11 Yu Quan Ng; Trisha P. Gupte; Peter J. Krause
Immune mediated hypersensitivity reactions to ticks and other arthropods are well documented. Hypersensitivity to ixodid (hard bodied) ticks is especially important because they transmit infection to humans throughout the world and are responsible for most vector‐borne diseases in the United States. The causative pathogens of these diseases are transmitted in tick saliva that is secreted into the host
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Editorial: Immunobiology of Tick‐Host‐Pathogen Interactions Parasite Immunol. (IF 2.054) Pub Date : 2021-01-09 Stephen Wikel
This special issue of Parasite Immunology focuses on the scope of immune interactions that take place within the triad of ticks, their vertebrate hosts, and tick‐borne pathogens. Ticks and tick‐borne infections are global medical and veterinary public health threats due to greater abundance and expanding geographic ranges of tick vectors; introduction of tick transmitted diseases into new areas; emerging
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Tick‐virus interactions: Current understanding and future perspectives Parasite Immunol. (IF 2.054) Pub Date : 2020-12-26 Charles Edward Hart; Saravanan Thangamani
Ticks are the primary vector of arboviruses in temperate climates worldwide. They are both the vector of these pathogens to humans and an integral component of the viral sylvatic cycle. Understanding the tick‐pathogen interaction provides information about the natural maintenance of these pathogens and informs the development of countermeasures against human infection. In this review, we discuss currently
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MicroRNA Profile in Immune Response of Alveolar and Cystic Echinococcosis Patients Parasite Immunol. (IF 2.054) Pub Date : 2021-01-07 Fadime Eroglu; Mehmet Dokur; Yüksel Ulu
It is known that miRNAs are effective in immune response in the diagnosis and treatment of many infectious diseases. However, the miRNAs profile is unknown in Alveolar and Cystic Echinococcosis which can be fatal if left untreated. The miRNAs profile that activates the T and B cells forming the immune system in Alveolar and Cystic Ecinococcosis patients was investigated in this study. A total of 50
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Glycan moieties in Entamoeba histolytica ubiquitin are immunodominant Parasite Immunol. (IF 2.054) Pub Date : 2020-12-03 María S. Flores; Adriana Obregón‐Cardenas; Roberto Rangel; Eva Tamez; Andrés Flores; Laura Trejo‐Avila; Isela Quintero; Katiushka Arévalo; María G. Maldonado; Fátima L. Gandarilla; Luis Galán
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Evolution of antigen‐specific immune responses in cutaneous leishmaniasis patients Parasite Immunol. (IF 2.054) Pub Date : 2020-12-22 Akram Miramin Mohammadi; Malcolm S. Duthie; Steven G. Reed; Amir Javadi; Ali Khamesipour
Despite immunization appearing to be the most appropriate strategy for long term control of the vector‐borne leishmaniases, no sustainable vaccine is currently available against any form of leishmaniasis. We therefore evaluated, in the context of vaccine antigen candidates, antigen‐specific immune response at various stages of cutaneous leishmaniasis (CL).
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Update on the intricate tango between tick microbiomes and tick‐borne pathogens Parasite Immunol. (IF 2.054) Pub Date : 2020-12-13 Sarah Irène Bonnet; Thomas Pollet
The recent development of high‐throughput NGS technologies, (ie, next‐generation sequencing) has highlighted the complexity of tick microbial communities—which include pathogens, symbionts, and commensals—and also their dynamic variability. Symbionts and commensals can confer crucial and diverse benefits to their hosts, playing nutritional roles or affecting fitness, development, nutrition, reproduction
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Development of an immunocompetent mouse model susceptible to Cryptosporidium tyzzeri infection Parasite Immunol. (IF 2.054) Pub Date : 2020-10-17 Y. Huang; Y. Song; Y. You; R. Mi; X. Han; H. Gong; Z. Chen; Y. Liu
Immunocompromised mice are extensively used in the screening of vaccines and drugs for Cryptosporidium, but this study model does not reflect the real status of infection in immunocompetent animals. This study aimed to provide an optimized animal model for future studies of Cryptosporidium vaccine.
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Protective immunity induced by CpG ODN‐adjuvanted virus‐like particles containing Toxoplasma gondii proteins Parasite Immunol. (IF 2.054) Pub Date : 2020-10-15 Hae‐Ji Kang; Ki‐Back Chu; Min‐Ju Kim; Su‐Hwa Lee; Hyunwoo Park; Hui Jin; Eun‐Kyung Moon; Fu‐Shi Quan
To date, a Toxoplasma gondii vaccine for clinical use remains unavailable, though multiple vaccine candidates have been suggested. In our previous studies, unadjuvanted virus‐like particles (VLPs) vaccines expressing multiple T. gondii antigens were confirmed to be protective against T. gondii challenge infection. Yet, the protective efficacy of adjuvanted T. gondii VLP in comparison with the unadjuvanted
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Acquired tick resistance: The trail is hot Parasite Immunol. (IF 2.054) Pub Date : 2020-11-13 Sukanya Narasimhan; Cheyne Kurokawa; Melody DeBlasio; Jaqueline Matias; Andaleeb Sajid; Utpal Pal; Geoffrey Lynn; Erol Fikrig
Acquired tick resistance is a phenomenon wherein the host elicits an immune response against tick salivary components upon repeated tick infestations. The immune responses, potentially directed against critical salivary components, thwart tick feeding, and the animal becomes resistant to subsequent tick infestations. The development of tick resistance is frequently observed when ticks feed on non‐natural
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Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis Parasite Immunol. (IF 2.054) Pub Date : 2020-11-28 Ester Cristina Borges Araujo; Yusmaris Cariaco; Marcos Paulo Oliveira Almeida; Marisol Patricia Pallete Briceño; José Eduardo Neto de Sousa; Wânia Rezende Lima; Julia Maria Costa‐Cruz; Neide Maria Silva
Toxoplasma gondii is a protozoan with worldwide distribution and triggers a strong Th1 immune response in infected susceptible hosts. On the contrary, most helminth infections are characterized by Th2 immune response and the use of helminth‐derived antigens to regulate immune response in inflammatory disorders has been broadly investigated.
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Soluble programmed death‐1 (sPD‐1) as predictor of early surgical outcomes of paediatric cystic echinococcosis Parasite Immunol. (IF 2.054) Pub Date : 2020-11-18 Eya Ben Salah; Wahiba Sakly; Coralie Barrera; Sana Mosbahi; Anne‐Pauline Bellanger; Rabeb Farhani; Amine Ksia; Bruno Gottstein; Abdellatif Nouri; Hamouda Babba; Laurence Millon
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A mushroom derived ‘carbohydrate‐fraction’ reinstates host‐immunity and protects from Leishmania donovani infection Parasite Immunol. (IF 2.054) Pub Date : 2020-10-31 Aabid Hussain; Sanhita Ghosh; Kamalika Roy; Supriya Nath; Biswajyoti Sarkar; Aritri Dutta; Priyankar Maji; Shibani Basu; Sharmistha Paul; Somaditya Dey; Kakuli Chakraborty; Bikramjit Raychaudhury; Krishnendu Acharya; Jhuma Ganguly; Chiranjib Pal
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CXCL10 immunomodulatory effect against infection caused by an antimony refractory isolate of Leishmania braziliensis in mice Parasite Immunol. (IF 2.054) Pub Date : 2020-10-31 Brunheld Maia Dutra; Naya Lúcia de Castro Rodrigues; Francisco Rafael Marciano Fonseca; Tatiana Rodrigues de Moura; Roque Pacheco de Almeida; Amélia Ribeiro de Jesus; Ticiana Monteiro Abreu; Margarida Maria de Lima Pompeu; Clarissa Romero Teixeira; Maria Jania Teixeira
Leishmania braziliensis is the main causative agent of American tegumentary leishmaniasis in Brazil. Current treatment includes different drugs that have important side effects and identification of cases of parasite resistance to treatment support the search for new therapeutic strategies. Recent findings have indicated that CXCL10, a chemokine that recruits and activates Th1 cells, NK cells, macrophages
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Tick salivary gland transcriptomics and proteomics Parasite Immunol. (IF 2.054) Pub Date : 2020-11-01 Larissa Almeida Martins; Chaima Bensaoud; Jan Kotál; Jindřich Chmelař; Michail Kotsyfakis
‘Omics’ technologies have facilitated the identification of hundreds to thousands of tick molecules that mediate tick feeding and play a role in the transmission of tick‐borne diseases. Deep sequencing methodologies have played a key role in this knowledge accumulation, profoundly facilitating the study of the biology of disease vectors lacking reference genomes. For example, the nucleotide sequences
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The role of basophils in acquired protective immunity to tick infestation Parasite Immunol. (IF 2.054) Pub Date : 2020-10-30 Soichiro Yoshikawa; Kensuke Miyake; Atsunori Kamiya; Hajime Karasuyama
Ticks are blood‐feeding ectoparasites that transmit a variety of pathogens to host animals and humans, causing severe infectious diseases such as Lyme disease. In a certain combination of animal and tick species, tick infestation elicits acquired immunity against ticks in the host, which can reduce the ability of ticks to feed on blood and to transmit pathogens in the following tick infestations. Therefore
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Trichomonas vaginalis-secreted cysteinyl leukotrienes promote migration, degranulation and MCP-1 production in mast cells. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-03 Young Ah Lee,Young Hee Nam,Arim Min,Myeong Heon Shin
Trichomonas vaginalis, a flagellated extracellular protozoan parasite that infects the human genitourinary tract, is usually transmitted by sexual contact. Our previous study showed that the leukotriene B4 (LTB4), a T vaginalis‐secreted lipid mediator, induces interleukin (IL)‐8 production and promotes mast cell degranulation and migration via BLT1 in human. In this study, we investigated whether T vaginalis
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Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-07 João Henrique Barbosa Toscano,Cintia Hiromi Okino,Isabella Barbosa Dos Santos,Luciana Aparecida Giraldelo,Marei Borsch von Haehling,Sérgio Novita Esteves,Cesar Cristiano Bassetto,Alessandro Francisco Talamini do Amarante,Ana Carolina de Souza Chagas
Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes were evaluated.
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Dicrocoelium Ova Can Block the Induction Phase of Experimental Autoimmune Encephalomyelitis. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-13 Zahra Navi,Abdolmajid Fata,Mozhdeh Jafari Rad,Elham Mogaddas,Mahmoud Mahmoudi,Maryam Rastin,Mojtaba Mousavi Bazaz,Fahimeh Lavi Arab,Sajad Sahab Negah,Amir Reza Heidari
This study aimed at investigating the impact of Dicrocoelium ova on experimental autoimmune encephalomyelitis (EAE) treatment in C57BL6 mice.
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Development of Acanthocheilonema viteae in Meriones shawi: Absence of microfilariae and production of active ES‐62 Parasite Immunol. (IF 2.054) Pub Date : 2020-10-22 Felicity E. Lumb; James Doonan; Marlene Corbet; Miguel A. Pineda; Margaret M. Harnett; William Harnett
ES‐62 is a well‐studied anti‐inflammatory molecule secreted by L4‐adult stage Acanthocheilonema viteae. We maintain the life cycle of A viteae using Meriones libycus as the definitive host. Here, we investigated whether the full life cycle could be maintained, and functional ES‐62 produced, in a related jird species—Meriones shawi.
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Polyreactive antibodies as potential humoral biomarkers of host resistance to cystic echinococcosis Parasite Immunol. (IF 2.054) Pub Date : 2020-10-23 Joaquín García‐Luna; Javier Magnone; Sebastián Miles; Camila López‐Santurio; Sylvia Dematteis; Gustavo Mourglia‐Ettlin
Polyreactive antibodies (pAb) bind to a broad range of unrelated structures, providing hosts with functional components able to rapidly recognize and protect against different pathogens. However, their roles against helminth parasites are still unexplored. Here, pAb profiles were analysed in cystic echinococcosis (CE), a zoonosis caused by the cestode Echinococcus granulosus sensu lato. Levels of anti‐DNP
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In situ study of cellular immune response in human cutaneous lesions caused by Leishmania (Viannia) panamensis in Panama Parasite Immunol. (IF 2.054) Pub Date : 2020-10-17 Kadir Gonzalez; José Eduardo Calzada; Thaise Yumie Tomokane; Carmen Maria Sandoval Pacheco; Gabriela Venicia Araujo Flores; Cláudia Maria Castro Gomes; Carlos Eduardo Pereira Corbett; Azael Saldaña; Marcia Dalastra Laurenti
Leishmaniasis is considered a disease with multiple clinical/immunopathological characteristics, depending on the immunity of the host and the species of the parasite. In Panama, the most prevalent species that causes localized cutaneous leishmaniasis (LCL) is Leishmania (Viannia) panamensis, and its immune response is poorly studied. Therefore, we evaluated by immunohistochemistry, the in situ immune
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Immunopathology and modulation induced by hookworms: From understanding to intervention Parasite Immunol. (IF 2.054) Pub Date : 2020-10-04 Luisa Mourão Dias Magalhães; Livia Silva Araújo Passos; Ricardo Toshio Fujiwara; Lilian Lacerda Bueno
Hookworm infection is considered the most prevalent human soil‐transmitted helminth infection affecting approximately 500 million people and accounting for 3.2 million disability‐adjusted life years lost annually. As with many other neglected tropical diseases, no international surveillance mechanisms that show accurate data on the prevalence of hookworm infection are in place, thus hindering strategies
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Featured Cover Parasite Immunol. (IF 2.054) Pub Date : 2020-10-16 Su‐Hwa Lee; Ki‐Back Chu; Hae‐Ji Kang; Swarnendu Basak; Min‐Ju Kim; Hyunwoo Park; Hui Jin; Eun‐Kyung Moon; Fu‐Shi Quan
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Immune responses to malaria pre‐erythrocytic stages: Implications for vaccine development Parasite Immunol. (IF 2.054) Pub Date : 2020-09-27 Kelvin Mokaya Abuga; William Jones‐Warner; Julius Clemence R. Hafalla
Radiation‐attenuated sporozoites induce sterilizing immunity and remain the 'gold standard' for malaria vaccine development. Despite practical challenges in translating these whole sporozoite vaccines to large‐scale intervention programmes, they have provided an excellent platform to dissect the immune responses to malaria pre‐erythrocytic (PE) stages, comprising both sporozoites and exoerythrocytic
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Biomarkers of the early response to treatment of visceral leishmaniasis: A prospective cohort study Parasite Immunol. (IF 2.054) Pub Date : 2020-09-27 Simone S. Lima; Débora Cavalcante Braz; Vladimir Costa Silva; Teresinha J. C. Farias; Danielle Alves Zacarias; Jailthon Carlos da Silva; Carlos Henrique Nery Costa; Dorcas Lamounier Costa
Early biomarkers of the response to treatment are lacking and may help to reduce mortality by the vector‐borne disease visceral leishmaniasis (VL).
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DX5+NKT cells’ increase was correlated with liver damage in FVB mice not in BALB/c mice infected by Clonorchis sinensis Parasite Immunol. (IF 2.054) Pub Date : 2020-09-27 Xuelian Bai; Nan Wang; Jie Zhou; Min Cui; Xuening Jing; Naiguo Liu
DX5+NKT cells’ distribution and population change in BALB/c and FVB mice infected by C sinensis and their function in liver damage were investigated.
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Host-parasite dynamics in Chagas disease from systemic to hyper-local scales. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-16 Damián Pérez-Mazliah,Alexander I Ward,Michael D Lewis
Trypanosoma cruzi is a remarkably versatile parasite. It can parasitize almost any nucleated cell type and naturally infects hundreds of mammal species across much of the Americas. In humans, it is the cause of Chagas disease, a set of mainly chronic conditions predominantly affecting the heart and gastrointestinal tract, which can progress to become life threatening. Yet around two thirds of infected
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Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-11 Ivet A Yordanova,Martin Lamatsch,Anja A Kühl,Susanne Hartmann,Sebastian Rausch
IgA and Th17 responses are pivotal for the control of Giardia infections. Eosinophils support IgA class switching, the survival of intestinal IgA+ plasma cells at steady state and can control Th17 activity in the small intestine. To see whether eosinophils regulate adaptive immune responses during giardiasis, we investigated Giardia muris infections in wild‐type BALB/c and eosinophil‐deficient ∆dblGATA‐1
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Cytokine responses to various larval stages of equine strongyles and modulatory effects of the adjuvant G3 in vitro. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-24 Stina Hellman,Eva Tydén,Bernt Hjertner,Frida Nilsfors,Kefei Hu,Bror Morein,Caroline Fossum
To generate different larval stages of Strongylus vulgaris and to study cytokine responses in cultures of eqPBMC exposed to defined larval stages of S. vulgaris and cyathostomins with the aim to understand the early immune reaction to these parasites.
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Strongyloides-specific IgA, IgG, and IgG immune complex profile in patients with pulmonary tuberculosis. Parasite Immunol. (IF 2.054) Pub Date : 2020-09-24 Larissa Rodrigues Bosqui,Gabriela Borges da Silva,Henrique Tomaz Gonzaga,Ana Lúcia Ribeiro Gonçalves,Luiz Antonio Custodio,Wander Rogério Pavanelli,Ivete Conchon-Costa,Fabiana Martins de Paula,Julia Maria Costa-Cruz,Idessania Nazareth da Costa
To describe an anti‐Strongyloides IgA, IgG and IgG immune complex antibody response profile in patients with pulmonary tuberculosis.
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Psoroptes ovis-Early Immunoreactive Protein (Pso-EIP-1) a novel diagnostic antigen for sheep scab. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-27 Stewart T G Burgess,Francesca Nunn,Kath Bartley,David Frew,Kevin McLean,Neil F Inglis,Kara McGeachy,Michael E Taliansky,Andrew J Love,Andrew J Nisbet
Serodiagnosis of sheep scab is an established diagnostic method and has become popular in recent years. However, the current diagnostic antigen, Pso o 2, has shown promise as a component of a recombinant vaccine for scab, making it incompatible with discriminating between infected and vaccinated animals (DIVA). Here, we describe the discovery and characterization of a novel Psoroptes ovis immunodiagnostic
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Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-21 Felix Llanwarne,Helena Helmby
Schistosomiasis is the most important helminth disease in the world from a public health perspective. S mansoni and S japonicum account for the majority of global intestinal schistosomiasis cases, and the pathogenesis is widely assumed to be fundamentally similar. However, the majority of research on schistosomiasis has been carried out on S mansoni and comparisons between the two species are rarely
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Treatment effects on IL-9+CD4+ T cells and the cytokines influencing IL-9 production in paediatric visceral leishmaniasis. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-18 Ali Moravej,Maral Choopanizadeh,Bahman Pourabbas,Gholamreza Pouladfar,Mehdi Kalani
Given the involvement of IL‐9 in the immune responses to parasitic infections, we aimed to determine alterations in the levels of IL‐9+CD4+ T cells and the cytokines influencing their differentiations and functions following treatment in paediatric visceral leishmaniasis (VL).
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ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-12 Fei Guan,Chongyang Zhang,Chunjie Jiang,Muziazia Lupemba Jacques,Yang Bai,Shengjun Lu,Wenqi Liu,Jiahui Lei
The Schistosoma japonicum (S japonicum)‐infected ApoE gene deficiency (ApoE−/−) mice were used to determine effect of ApoE on hepatic immunopathology.
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CRISPR/Cas9 gene drive technology to control transmission of vector-borne parasitic infections. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-04 Mahmoud Nateghi Rostami
Gene drive is the process of copying of an endonuclease‐containing cassette that leads to increased frequency of inheritance of the desired traits in a targeted population. CRISPR/Cas9 technology is advancing genetic manipulation of insects in the field of gene drive experiments. The CRISPR/Cas9 drive could be engineered for genetic manipulation of parasites and/or vectors for disease control. A number
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Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-09 Isabela A G Pereira,Débora V C Mendonça,Grasiele S V Tavares,Daniela P Lage,Fernanda F Ramos,João A Oliveira-da-Silva,Luciana M R Antinarelli,Amanda S Machado,Lívia M Carvalho,Ana Maria R S Carvalho,Iorrana V Salustiano,Thiago A R Reis,Raquel S Bandeira,Alessandra M Silva,Vívian T Martins,Miguel A Chávez-Fumagalli,Maria V Humbert,Bruno M Roatt,Mariana C Duarte,Daniel Menezes-Souza,Elaine S Coimbra
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Stem cell-derived enteroid cultures as a tool for dissecting host-parasite interactions in the small intestinal epithelium. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-21 Miriam F Hares,Ellen-Alana Tiffney,Luke J Johnston,Lisa Luu,Christopher J Stewart,Robin J Flynn,Janine L Coombes
Toxoplasma gondii and Cryptosporidium spp. can cause devastating pathological effects in humans and livestock, and in particular to young or immunocompromised individuals. The current treatment plans for these enteric parasites are limited due to long drug courses, severe side effects or simply a lack of efficacy. The study of the early interactions between the parasites and the site of infection in
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Immunogenicity of HLA-DR1 and HLA-A2 peptides derived from Leishmania major Gp63 in golden hamsters. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-01 Larissa Pinheiro Silva,Mauricio Oviedo Paciello,Wéllida Patricia Aviz Teixeira,Açucena Veleh Rivas,Raimundo Wagner Souza Agular,Alex Sander Rodrigues Cangussu,Luiz Carlos Bertucci Barbosa,Reinaldo Marchetto,Rodolfo Cordeiro Giunchetti,Kelvinson Fernandes Viana
This study aimed to evaluate the toxicity and humoral and cellular immune response of three heterologous vaccines against Leishmania infantum, yet containing synthetic peptides from Leishmania major in the experimental model in hamsters.
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Virus-like particles expressing Plasmodium berghei MSP-8 induce protection against P. berghei infection. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-01 Su-Hwa Lee,Ki-Back Chu,Hae-Ji Kang,Swarnendu Basak,Min-Ju Kim,Hyunwoo Park,Hui Jin,Eun-Kyung Moon,Fu-Shi Quan
Merozoite surface protein 8 (MSP‐8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate.
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RNA-Seq analysis of the guppy immune response against Gyrodactylus bullatarudis infection. Parasite Immunol. (IF 2.054) Pub Date : 2020-08-01 Mateusz Konczal,Amy R Ellison,Karl P Phillips,Jacek Radwan,Ryan S Mohammed,Joanne Cable,Magdalena Chadzinska
Gyrodactylids are ubiquitous ectoparasites of teleost fish, but our understanding of the host immune response against them is fragmentary. Here, we used RNA‐Seq to investigate genes involved in the primary response to infection with Gyrodactylus bullatarudis on the skin of guppies, Poecilia reticulata, an important evolutionary model, but also one of the most common fish in the global ornamental trade
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Status of IL-4 and IL-10 driven markers in experimental models of Visceral Leishmaniasis. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-31 Srija Moulik,Joyshree Karmakar,Sumit Joshi,Anuradha Dube,Chitra Mandal,Mitali Chatterjee
Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates host monocytes/macrophages to ensure its survival. However, knowledge regarding the host‐parasite interactions underpinning the disease remains limited. As disease progression is associated with polarization of monocytes/macrophages towards M2, which is regulated by cytokines IL‐4/IL‐13 and IL‐10, this study evaluated
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Fasciola hepatica products can alter the response of bovine immune cells to Mycobacterium avium subsp. paratuberculosis. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-29 Amalia Naranjo-Lucena,Andrés García-Campos,Laura Garza-Cuartero,Louise Britton,Alfonso Blanco,Annetta Zintl,Grace Mulcahy
Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties.
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Identification of a HSP14-3-3 in Setaria cervi and its cross-reactivity with W bancrofti-infected human sera. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-18 Faiyaz Ahmad,Ranjeet Kumar,Sarika Gupta,Sushma Rathaur
Identification of a 29 kDa heat stress protein in filarial parasite Setaria cervi and evaluation of its diagnostic potential against lymphatic filariasis.
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Amoebic gill disease and host response in Atlantic salmon (Salmo salar L.): A review. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-21 Mar Marcos-López,Hamish D Rodger
Gill health is one of the main health challenges for Atlantic salmon (Salmo salar L.) mariculture worldwide, and amoebic gill disease (AGD), caused by the marine ectoprotozoan Neoparamoeba perurans , is currently one of the most significant diseases in terms of prevalence and economic impact. This review describes the host response of Atlantic salmon to the disease, focusing on the pathological changes
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Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite Immunol. (IF 2.054) Pub Date : 2020-05-13 Laura M Braden,Sean J Monaghan,Mark D Fast
The salmon louse Lepeophtheirus salmonis (Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and
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A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout. Parasite Immunol. (IF 2.054) Pub Date : 2020-05-13 Christyn Bailey,Jason W Holland,Christopher J Secombes,Carolina Tafalla
Proliferative kidney disease (PKD), caused by the myxozoan Tetracapsuloides bryosalmonae, is one of the most serious parasitic diseases of salmonids in which outbreaks cause severe economic constraints for the aquaculture industry and declines of wild species throughout Europe and North America. Given that rainbow trout (Oncorhynchus mykiss ) is one of the most widely farmed freshwater fish and an
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Attempts to induce tolerance to Trichostrongylus colubriformis infection in sheep. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-16 Sara S Lundberg,Tom N McNeilly,Robin W McAnulty,Andrew W Greer
The possibility of manipulating the immune response in lambs to the gastrointestinal nematode Trichostrongylus colubriformis to reduce production losses associated with infection was investigated. In a series of four experiments, attempts to immunize sheep via the mucosal route to modify the immune response and induce mucosal tolerance are outlined. Initially, a proof of concept study was conducted
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Association of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population. Parasite Immunol. (IF 2.054) Pub Date : 2020-07-13 Fatma Esin Kirik,Mahmut Ülger,Seda Tezcan Ülger,Gönül Aslan
The objective of this study was to determine the association of TNF‐α −308 G/A, IFN‐γ +874 T/A, IL‐12B + 1188 A/C, IL‐10 −1082 G/A and IL‐4 −590 C/T polymorphisms with susceptibility to CL.
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Death from an Adult‐onset Still’s disease triggered by visceral leishmaniasis Parasite Immunol. (IF 2.054) Pub Date : 2020-07-07 Donghong Wang; Qiong Huang; Yong Wang; Junxian Guo; Zhongshu Pu
A 24‐year‐old patient presented with a 4‐month‐long high‐spiking fever, characteristic rash, sore throat and arthralgias. Bone marrow biopsy examination demonstrated visceral leishmaniasis with the presence of typical Leishman‐Donovan bodies. During the treatment for visceral leishmaniasis with the sodium stibogluconate, he died suddenly. According to the symptoms, we infer that the patient catch the
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Prospective study of serum and aqueous humour anti-Hsp70.1 IgG antibody levels in ocular toxoplasmosis. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-30 Christophe Chiquet,Bernabé Chumpitazi,Isabelle Vilgrain,Anne Lesoin,Helene Fricker-Hidalgo,Marie-Pierre Brenier-Pinchart,Caroline Vasseneix,Olivier Savy,Nelly Campolmi,Philippe Gain,Pierre Flori,Florent Aptel,Hervé Pelloux,Laurence Bouillet
We evaluate whether the serum and aqueous humour (AH) level of IgG anti‐Hsp70.1 antibodies improved the biological diagnosis of ocular toxoplasmosis.
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Characterization of ovine monocyte activity when cultured with Haemonchus contortus larvae in vitro. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-30 Elizabeth Shepherd,Scott P Greiner,Scott A Bowdridge
The objective of this study was to identify and characterize cell populations within ovine peripheral blood mononuclear cells (PBMCs) associated with Haemonchus contortus (Hc) larval morbidity and impairment in vitro.
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Th17 lymphocytes in atypical cutaneous leishmaniasis caused by Leishmania (L.) infantum chagasi in Central America. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-30 Gabriela Venicia Araujo Flores,Carmen Maria Sandoval Pacheco,Wilfredo Humberto Sosa Ochoa,Cláudia Maria Castro Gomes,Concepción Zúniga,Carlos P Corbett,Marcia Dalastra Laurenti
Skin lesions in nonulcerated cutaneous leishmaniasis (NUCL) caused by Leishmania (L.) infantum chagasi are characterized by a mononuclear inflammatory infiltrate in the dermis, which is composed mainly of lymphocytes, followed by macrophages, few plasma cells and epithelioid granulomas with mild tissue parasitism. Previous studies have shown that the main population of lymphocytes present in the dermal
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Differential antibody responses to Giardia lamblia strain variants expressing dissimilar levels of an immunogenic protein. Parasite Immunol. (IF 2.054) Pub Date : 2020-06-28 Thania Garzon,Lourdes Valencia,Victor Dominguez,Lucila Rascon,Jael Quintero,Adriana Garibay-Escobar,Ramón Enrique Robles-Zepeda,Carlos Velazquez
Giardia lamblia is a protozoan parasite that causes giardiasis, one of the most common worldwide gastrointestinal diseases. For rational development of a Giardia vaccine, increasing our understanding of the host‐Giardia interaction is crucial. In this study, we analysed the immunogenicity and antigenicity of two G lamblia strain variants [GS and GS‐5G8 (+)], which express different levels of the variant‐specific
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