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Detection of efflux pump genes in multiresistant Acinetobacter baumannii ST2 in Iran. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-02-02 Zahra Meshkat; Himen Salimizand; Yousef Amini; Davood Mansury; Abolfazl Rafati Zomorodi; Zoleikha Avestan; Azad Jamee; Jamal Falahi; Hadi Farsiani; Azizollah Mojahed
Acinetobacter baumannii, as a nosocomial pathogen has become a worldwide concern in recent years. In the current study, the resistance to tetracyclines and colistin were assessed in the isolates from different provinces of Iran.During the timeline of this study, a number of 270 isolates of A. baumannii were collected from tracheal aspirates, wounds, urine and blood cultures. The minimum inhibitory
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Interactions between immune system and the microbiome of skin, blood and gut in pathogenesis of rosacea. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-01-29 Marie Isolde Joura; Alexandra Brunner; Éva Nemes-Nikodém; Miklós Sárdy; Eszter Ostorházi
The increasingly wide use of next-generation sequencing technologies has revolutionised our knowledge of microbial environments associated with human skin, gastrointestinal tract and blood. The collective set of microorganisms influences metabolic processes, affects immune responses, and so directly or indirectly modulates disease. Rosacea is a skin condition of abnormal inflammation and vascular dysfunction
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Ceftazidime/avibactam and eravacycline susceptibility of carbapenem-resistant Klebsiella pneumoniae in two Greek tertiary teaching hospitals. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-01-29 Maria Chatzidimitriou; Panagiota Chatzivasileiou; Georgios Sakellariou; MariaAnna Kyriazidi; Asimoula Kavvada; Dimitris Chatzidimitriou; Fani Chatzopoulou; Georgios Meletis; Maria Mavridou; Dimitris Rousis; Eleni Katsifa; Eleni Vagdatli; Stella Mitka; Lialiaris Theodoros
The present study evaluated the carbapenem resistance mechanisms of Klebsiella pneumoniae strains isolated in two Greek tertiary teaching hospitals and their susceptibility to currently used and novel antimicrobial agents.Forty-seven carbapenem resistant K. pneumoniae strains were collected in G. Papanikolaou and Ippokrateio hospital of Thessaloniki between 2016 and 2018. Strain identification and
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Detection of colistin resistance among multidrug-resistant Klebsiella pneumoniae and Escherichia coli clinical isolates in Turkey. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-01-27 Nilgün Kansak; Sebahat Aksaray; Müge Aslan; Rıza Adaleti; Nevriye Gönüllü
In this study investigation of plasmid-mediated mcr 1-5 resistance genes was performed among multidrug-resistant (MDR) colistin sensitive and resistant Klebsiella pneumoniae and Escherichia coli strains isolated in our laboratory. We aimed to evaluate automated system (Vitek-2), broth microdilution (BMD) reference method and chromogenic media performance. Totally 94 MDR K. pneumoniae and six E. coli
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Simultaneous detection of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae by quantitative PCR from CSF samples with negative culture in Morocco. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-01-27 Youssef Ikken; Amina Benaouda; Latifa Ibn Yaich; Farida Hilali; Yassine Sekhsokh; Réda Charof
Bacteriological cultures from cerebrospinal fluids (CSF) have less sensitivity and specificity compared to quantitative PCR (RT-PCR), and multiple facts still conduct to the increase of negative culture. The aims of this study are to determine the molecular epidemiology and the simultaneous detection of bacterial meningitis in Morocco by using RT-PCR and compared this molecular approach with culture
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Enteric pathogenic bacteria and resistance gene carriage in the homeless population in Marseille, France. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2021-01-27 Tran Duc Anh Ly; Linda Hadjadj; Van Thuan Hoang; Ndiaw Goumbala; Thi Loi Dao; Sekene Badiaga; Herve Tissot-Dupont; Philippe Brouqui; Didier Raoult; Jean-Marc Rolain; Philippe Gautret
We aimed to assess the prevalence of pathogenic bacteria and resistance genes in rectal samples collected among homeless persons in Marseille, France. In February 2014 we enrolled 114 sheltered homeless adults who completed questionnaires and had rectal samples collected. Eight types of enteric bacteria and 15 antibiotic resistance genes (ARGs) were sought by real-time polymerase chain reaction (qPCR)
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Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010-2018. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-12-05 Erika Bujaki; Ágnes Farkas; Zita Rigó; Mária Takács
This report provides the findings of a retrospective surveillance study on the emergence and circulation of enteroviruses with their associated clinical symptoms over a nine-year period detected at the National Enterovirus Reference Laboratory in Hungary between 2010-2018.Enterovirus (EV) detection and genotyping were performed directly from clinical samples. From 4,080 clinical specimens 25 EV types
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Helicobacter pylori infection is associated with anemia, weight loss or both conditions among Bulgarian children. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-12-01 Lyudmila Boyanova; Petyo Hadzhiyski
Some studies suggested an association between Helicobacter pylori infection and iron-deficiency anemia, however, the link between weight loss and the infection in childhood remains non-established. In a retrospective cohort study, we compared H. pylori positivity rates of Bulgarian children without or with anemia (47 children in each group) or weight loss (45 children in each group) and both conditions
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Detection of VIM, NDM and OXA-48 producing carbapenem resistant Enterobacterales among clinical isolates in Southern Hungary. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-12-01 Márió Gajdács; Marianna Ábrók; Andrea Lázár; Laura Jánvári; Ákos Tóth; Gabriella Terhes; Katalin Burián
Infections caused by carbapenem-resistant Enterobacterales (CRE) present an important therapeutic problem, as there are limited number of effective therapeutic alternatives available. In this study, phenotypic and genotypic methods were used to characterize carbapenemase-production and other resistance-determinants (AmpC and ESBL-production, efflux pump-overexpression) in 50 isolates (Klebsiella spp
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Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-12-01 Amin Khoshbayan; Aref Shariati; Ehsanollah Ghaznavi-Rad; Alex van Belkum; Davood Darban-Sarokhalil
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP2a).
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Identification and antifungal susceptibility of Saprochaete clavata from invasive infections in Turkey. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-30 Esra Özkaya; İlknur Tosun; Enis Fuat Tüfekçi; Celal Kurtuluş Buruk; Neşe Kaklıkkaya; Faruk Aydın
Saprochaete clavata is an emerging opportunistic pathogen, that causes life-threatening infections, but there are limited evidence and information about the evaluation of in vitro antifungal susceptibility test results. The aim of this study was to determine S. clavata isolates from clinical specimens and to investigate their in vitro antifungal susceptibility. S. clavata was identified by API ID20C
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Investigation of carbapenem resistant Acinetobacter baumannii ST2 in Iran. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-28 Aliakbar Rezaei; Hossein Fazeli; Jamshid Faghri
This study investigated carbapenem resistance among Acinetobacter baumannii isolated from respiratory specimens. Epidemiological relationship of the isolates was also evaluated. In this study, 81 respiratory specimens of A. baumannii from AL Zahra Hospital were confirmed by phenotypic and genotypic methods. Antimicrobial susceptibility was performed by disc diffusion method. Carbapenem resistance genes
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Relationship between MLSB resistance and the prevalent virulence genotypes among Bulgarian Staphylococcus aureus isolates. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-28 Virna-Maria Tsitou; Ivan Mitov; Raina Gergova
The aim of this study was to investigate the rate of resistance to macrolide-lincosamide-streptogramin B (MLSB) antibiotics, the mechanisms underlying this resistance and to evaluate their relationship with virulence genes profiles of 435 Bulgarian clinical isolates Staphylococcus aureus. The highest resistance was observed to penicillin (96.09%), followed by resistance to erythromycin and clindamycin
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Epidemiology and antibiotic resistance profile of bacterial meningitis in Morocco from 2015 to 2018. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-21 Youssef Ikken; Réda Charof; Amina Benaouda; Farida Hilali; Sanae Akkaoui; Mostafa Elouennass; Yassine Sekhsokh
Over a 4-year study period from 2015 to 2018, altogether 183 isolates of bacterial meningitis were collected from 12 hospitals covering the entire Moroccan territory. Neisseria meningitidis represented 58.5%, Streptococcus pneumoniae 35.5%, and Haemophilus influenzae type b 6%. H. influenzae type b mainly affected 5-year-olds and unvaccinated adults. N. meningitidis serogroup B represented 90.7% followed
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Clonal spread of PER-1 and OXA-23 producing extensively drug resistant Acinetobacter baumannii during an outbreak in a burn intensive care unit in Tunisia. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-18 Aymen Mabrouk; Yosra Chebbi; Anis Raddaoui; Asma Krir; Amen Allah Messadi; Wafa Achour; Lamia Thabet
Extensively drug resistant Acinetobacter baumannii (XDR-Ab), has emerged as an important pathogen in several outbreaks. The aim of our study was to investigate the eventual genetic relatedness of XDR-Ab strains recovered from burn patients and environment sites in the largest Tunisian Burn Intensive Care Unit (BICU) and to characterize β-lactamase encoding genes in these strains. Between March 04th
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Antibiotic induced biofilm formation of novel multidrug resistant Acinetobacter baumannii ST2121 clone. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-11 Müberra Çimen; Azer Özad Düzgün
The aim of this study was to identify antimicrobial resistance and virulence factor genes exhibited by multidrug resistant (MDR) Acinetobacter baumannii, to analyze biofilm formation and to investigate clonal subtypes of isolate. Whole genome sequencing was done by Illumina NovaSeq 6,000 platform and multilocus sequence typing (MLST) was performed by Oxford and Pasteur typing schemes. Influence of
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Emergence of carbapenemase-producing and colistin resistant Klebsiella pneumoniae ST101 high-risk clone in Turkey. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-11-09 Gülşen Hazırolan; Alper Karagöz
Carbapenemase-producing and colistin resistant Klebsiella pneumoniae has become a worldwide healthcare problem. This study describes molecular characterization of carbapenemase-producing and colistin resistant clinical K. pneumoniae isolates.A total of 93 non-replicate carbapenem and colistin resistant K. pneumoniae were recovered from clinical specimens in a university hospital during 2017-2019. Detection
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Possible contribution of trained immunity in faulty hormonal imprinting and DOHaD: Review and hypothesis. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-09-30 György Csaba
The faulty hormonal imprinting theory (published in 1980) and the DOHaD (Developmental Origin of Health and Disease theory (published in 1986) are twin-concepts: both justify the manifestation after long time (in adults) diseases which had been provoked in differentiating cells (e.g. during gestation). This was demonstrated using animal experiments as well, as comparative statistical methods (in human
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Herd immunization with childhood vaccination may provide protection against COVID-19. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-09-26 Yongqiang Yu
It may take time to obtain a vaccine for the current COVID-19, and the virus genome may keep an evolution and mutations, so a universal and effective vaccine for the coronavirus may not be possible. Epidemiological studies reveal the infection of SARS and COVID-19 in children is less frequent and less severe than in adults. Childhood vaccine-mediated cross cellular immunity and immunomodulation might
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Upregulation of efrAB efflux pump among Enterococcus faecalis ST480, ST847 in Iran. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-09-25 Seyedeh Marzieh Jabbari Shiadeh; Leila Azimi; Taher Azimi; Ali Pourmohammad; Mehdi Goudarzi; Bahare Gholami Chaboki; Ali Hashemi
Antibiotic resistance and especially multiresistance in Enterococci, is a serious public health issue especially in infections of immunocompromised patients. EfrAB is a heterodimeric multidrug ATP-binding cassette (ABC) transporter that causes endogenous resistance to antimicrobials including fluoroquinolones in Enterococcus spp. The aim of this study was to seek the gene expression rate and role of
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An alternative for urine cultures: Direct identification of uropathogens from urine by MALDI-TOF MS. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-09-24 Arzu Akşit İlki,Sevim Özsoy,Gulşen Gelmez,Burak Aksu,Güner Söyletir
Urinary tract infections are one of the most common bacterial infections and rapid diagnosis of the infection is essential for appropriate antibiotic therapy. The goal of our study was to identify urinary pathogens directly by MALDI-TOF MS and to perform antibiotic susceptibility tests in order to shorten the period spent for culturing.Urine samples submitted for culture to the Clinical Microbiology
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Effects of different decontaminating solutions used for the treatment of peri-implantitis on the growth of Porphyromonas gingivalis-an in vitro study. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2020-08-25 Ibrahim Barrak,Zoltán Baráth,Tamás Tián,Annamária Venkei,Márió Gajdács,Edit Urbán,Anette Stájer
Implants have been considered the treatment of choice to replace missing teeth, unfortunately, peri-implant disease is still an unresolved issue. Contaminated implants may be decontaminated by physical debridement and chemical disinfectants; however, there is a lack of consensus regarding the ideal techniques/agents to be used for the decontamination. The objective of our study was to compare the decontaminating
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Microbiological investigations on the water of a thermal bath at Budapest. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Sára Szuróczki,Zsuzsa Kéki,Szandra Káli,Anett Lippai,Károly Márialigeti,Erika Tóth
Thermal baths are unique aquatic environments combining a wide variety of natural and anthropogenic ecological factors, which also appear in their microbiological state. There is limited information on the microbiology of thermal baths in their complexity, tracking community shifts from the thermal wells to the pools. In the present study, the natural microbial community of well and pool waters in
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Education of hand rubbing technique to prospective medical staff, employing UV-based digital imaging technology. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Ákos Lehotsky,László Szilágyi,Annamária Demeter-Iclănzan,Tamás Haidegger,György Wéber
The aim of this study was to objectively assess the hand hygiene performance of medical students. Hand rubbing technique was evaluated by employing innovative UV-light-based imaging technology, identifying patterns and trends in missed areas after applying WHO's six-step protocol. This specially designed hand hygiene education and assessment program targeted 1,344 medical students at two distant sites
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Salmonella infection in healthy pet reptiles: Bacteriological isolation and study of some pathogenic characters. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Fabrizio Bertelloni,Marianne Chemaly,Domenico Cerri,Françoise Le Gall,Valentina Virginia Ebani
The fecal samples from 213 captive reptiles were examined, and 29 (13.61%) Salmonella enterica isolates were detected: 14/62 (22.58%) from chelonians, 14/135 (10.37%) from saurians, and 1/16 (6.25%) from ophidians. The isolates were distributed among 14 different serotypes: Miami, Ebrie, Hermannsweder, Tiergarten, Tornov, Pomona, Poona, Goteborg, Abaetetube, Nyanza, Kumasi, Typhimurium, 50:b:z6, 9
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A rough set based rational clustering framework for determining correlated genes. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Jeba Emilyn Jeyaswamidoss,Kesavan Thangaraj,Kadarkarai Ramar,Muthusamy Chitra
Cluster analysis plays a foremost role in identifying groups of genes that show similar behavior under a set of experimental conditions. Several clustering algorithms have been proposed for identifying gene behaviors and to understand their significance. The principal aim of this work is to develop an intelligent rough clustering technique, which will efficiently remove the irrelevant dimensions in
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Laboratory identification of anaerobic bacteria isolated on Clostridium difficile selective medium. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Cristina Rodriguez,Nathalie Warszawski,Nicolas Korsak,Bernard Taminiau,Johan Van Broeck,Michel Delmée,Georges Daube
Despite increasing interest in the bacterium, the methodology for Clostridium difficile recovery has not yet been standardized. Cycloserine-cefoxitin fructose taurocholate (CCFT) has historically been the most used medium for C. difficile isolation from human, animal, environmental, and food samples, and presumptive identification is usually based on colony morphologies. However, CCFT is not totally
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Effect of topical anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 Endang W Bachtiar,Anggraeni Afdhal,Ratna Meidyawati,Retno D Soejoedono,Erni Poerwaningsih
This study aims to evaluate the effect of anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface. Sprague Dawley rats were exposed intra-orally with S. mutans Xc and were fed a caries-inducing diet 2000. The 24 rats were divided into four groups: group A had their teeth coated with IgY gel; group B received sterilized water as a control; group C had their teeth coated with
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The Immunoendocrine Thymus as a Pacemaker of Lifespan. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-6-30 György Csaba
The thymus develops from an endocrine area of the foregut, and retains the ancient potencies of this region. However, later it is populated by bone marrow originated lymphatic elements and forms a combined organ, which is a central part of the immune system as well as an influential element of the endocrine orchestra. Thymus produces self-hormones (thymulin, thymosin, thymopentin, and thymus humoral
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Contribution of the Kallikrein/Kinin System to the Mediation of ConA-Induced Inflammatory Ascites. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Károly Baintner
Intraperitoneal administration of concanavalin A (ConA, 25 mg/kg b.w.), a cell-binding plant lectin was used for inducing inflammatory ascites, and potential inhibitors were tested in 1 h and 2.5 h experiments, i.e. still before the major influx of leucocytes. At the end of the experiment the peritoneal fluid was collected and measured. The ConA-induced ascites was significantly (p<0.01) and dose-dependently
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Seasonal and Spatial Changes of Planktonic Bacterial Communities Inhabiting the Natural Thermal Lake Hévíz, Hungary. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Gergely Krett,Zsuzsanna Nagymáté,Károly Márialigeti,Andrea K Borsodi
Lake Hévíz is a unique thermal spa located in Hungary. Owing to the thermal springs nourishing the lake, it has a relatively rapid water turnover. In spring 2011 a comprehensive embankment reconstruction was performed to preserve the water supply of the surrounding wetland habitats. The physical and chemical parameters as well as the planktonic microbial communities were studied with special respect
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Assessment of Periodontopathogens in Subgingival Biofilm of Banded and Bonded Molars in Early Phase of Fixed Orthodontic Treatment. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Krisztina Mártha,Lilla Lőrinczi,Cristina Bică,Réka Gyergyay,Blanka Petcu,Luminița Lazăr
To assess the prevalence and occurrence of eleven periodontopathogens in subgingival biofilm of banded and bonded molars during the first period of fixed orthodontic treatment. Subjects were selected from patients referred to orthodontic treatment and were divided in two groups: group A comprised fifteen patients (14.4±2.45 years of age) who received orthodontic bands on first permanent molars and
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Association of IFN-γ and P2X7 Receptor Gene Polymorphisms in Susceptibility to Tuberculosis Among Iranian Patients. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Mahdi Shamsi,Mohammad Reza Zolfaghari,Parissa Farnia
Interferon-gamma (IFN-γ) and P2X7 receptor are crucial for host defence against mycobacterial infections. Recent studies have indicated that IFN-γ, IFN-γ receptor 1 (IFN-γR1) andP2X7 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB). However, the relationship between IFN-γ and P2X7 polymorphism and TB susceptibility remains inconclusive in Iranian population. For
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High Prevalence and Resistance Patterns of Community-Associated Methicillin-Resistant Staphylococcus Aureus in the Pomoravlje Region, Serbia. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Zorica Lepsanovic,Ljiljana Petrovic Jeremic,Srdjan Lazic,Ivana Cirkovic
With a view to estimating the prevalence and resistance patterns of CA-MRSA in one region of Serbia, we performed an analysis of MRSA isolates from healthy people and hospitalised patients. The detection of CA-MRSA was carried out by SCCmec typing. In MRSA isolates from hospitalised patients SCCmec types IV and V were found in 76% of the strains. Similar percentage (80%) of CA-MRSA genotypes was present
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Comparison of Molecular and Phenotypic Methods for the Detection and Characterization of Carbapenem Resistant Enterobacteriaceae. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Ali M Somily,Ghada A Garaween,Norah Abukhalid,Muhammad M Absar,Abiola C Senok
In recent years, there has been a rapid dissemination of carbapenem resistant Enterobacteriaceae (CRE). This study aimed to compare phenotypic and molecular methods for detection and characterization of CRE isolates at a large tertiary care hospital in Saudi Arabia. This study was carried out between January 2011 and November 2013 at the King Khalid University Hospital (KKUH) in Saudi Arabia. Determination
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Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Jennifer Adeghate,Emese Juhász,Júlia Pongrácz,Éva Rimanóczy,Katalin Kristóf
Staphylococcus saprophyticus is a well-known urinary pathogen in acute cystitis in young females. We completed a retrospective overview of the distribution of urinary tract infections (UTIs) occurring in 2014, at Semmelweis University hospitals and at Heim Pál Children's Hospital. Six age-groups (ages 0-100) were examined, with the frequency of S. saprophyticus in females being: 0.1% (0-4), 0.7%, (5-15)
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Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Ozgur Pilanci,Sevgi Ergin,Serhat Sirekbasan,Idris Ersin,Zafer Habip,Pelin Yuksel,Nuray Kuvat,Mustafa Aslan,Oyku Dinc,Suat Saribas,Bekir Kocazeybek
Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the
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Antimicrobial Activity and Phylogenetic Analysis of Streptomyces Parvulus Dosmb-D105 Isolated from the Mangrove Sediments of Andaman Islands. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 R Baskaran,P M Mohan,K Sivakumar,Ashok Kumar
Actinomycetes, especially species of Streptomyces are prolific producers of pharmacologically significant compounds accounting for about 70% of the naturally derived antibiotics that are presently in clinical use. In this study, we used five solvents to extract the secondary metabolites from marine Streptomyces parvulus DOSMB-D105, which was isolated from the mangrove sediments of the South Andaman
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IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-3-30 Payam Behzadi,Elham Behzadi,Reza Ranjbar
Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural, functional, and immunological characteristics that have made this family as important immunological playmakers. Because of the importance of IL-12 heterodimeric cytokines in microbial infections, autoimmune diseases, and cancers, the authors of this literature discuss about the general characteristics of IL-12
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Epidemiology and antibiotic sensitivity of Staphylococcus aureus nasal carriage in children in Hungary. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-21 Krisztina Laub,Adrienn Tóthpál,Szilvia Kardos,Orsolya Dobay
The aim of this study was to assess the Staphylococcus aureus nasal carriage rate in healthy children all over Hungary and to specify some risk factors, the antibiotic resistance patterns of the bacteria, and their genetic relatedness. In total, 878 children (aged 3-6 years) were screened at 21 day-care centers in 16 different cities in Hungary, between February 2009 and December 2011. Samples taken
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First description of a rifampicin-resistant Neisseria meningitidis serogroup Y strain causing recurrent invasive meningococcal disease in Hungary. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-21 Ákos Tóth,Brigitta Berta,Tamás Tirczka,Csilla Jekkel,Anita Ábrahám,Zoltán Prohászka,Zsófia Bognár,Tímea Erdősi
A Hungarian soldier previously immunized against Neisseria meningitidis by quadrivalent polysaccharide vaccine was twice infected with meningococci within six weeks. The patient was treated with ceftriaxone during both episodes and he successfully recovered. His close contacts received rifampicin prophylaxis. An investigation was performed to characterize the genetic background of the pathogens to
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Synthesis and characterization of some abundant nanoparticles, their antimicrobial and enzyme inhibition activity. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-20 Shams T Khan,Ajmaluddin Malik,Rizwan Wahab,Omar H Abd-Elkader,Maqusood Ahamed,Javed Ahmad,Javed Musarrat,Maqsood A Siddiqui,Abdulaziz A Al-Khedhairy
Although the antimicrobial activity of the engineered nanoparticles (NPs) is well known, the biochemical mechanisms underlying this activity are not clearly understood. Therefore, four NPs with the highest global production, namely SiO2, TiO2, ZnO, and Ag, were synthesized and characterized. The synthesized SiO2, TiO2, ZnO, and Ag NPs exhibit an average size of 11.12, 13.4, 35, and 50 nm, respectively
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Virulotyping of Shigella spp. isolated from pediatric patients in Tehran, Iran. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-20 Reza Ranjbar,Masomeh Bolandian,Payam Behzadi
Shigellosis is a considerable infectious disease with high morbidity and mortality among children worldwide. In this survey the prevalence of four important virulence genes including ial, ipaH, set1A, and set1B were investigated among Shigella strains and the related gene profiles identified in the present investigation, stool specimens were collected from children who were referred to two hospitals
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Biofilm formation of Achromobacter xylosoxidans on contact lens. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-20 Neda Konstantinović,Ivana Ćirković,Slobodanka Đukić,Vesna Marić,Dragana D Božić
Achromobacter spp. may contaminate lenses, lens cases, and contact lens solutions and cause ocular infections. The aim of this study was to investigate the possibility of isolated strain of Achromobacter xylosoxidans to form biofilm on the surface of soft contact lenses (CL), to quantify the production of the formed biofilm, and compare it with the reference strains (Pseudomonas aeruginosa, Staphylococcus
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Novel adenovirus detected in kowari (Dasyuroides byrnei) with pneumonia. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2017-02-15 János Gál,Míra Mándoki,Endre Sós,Péter Kertész,Viktória Koroknai,Krisztián Bányai,Szilvia L Farkas
A male kowari (Dasyuroides byrnei) originating from a zoo facility was delivered for post mortem evaluation in Hungary. Acute lobar pneumonia with histopathologic changes resembling an adenovirus (AdV) infection was detected by light microscopic examination. The presence of an AdV was confirmed by obtaining partial sequence data from the adenoviral DNA-dependent DNA-polymerase. Although the exact taxonomic
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Fatal cases of disseminated nocardiosis: challenges to physicians and clinical microbiologists - Case report. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-31 Klára Piukovics,Viktória Bertalan,Gabriella Terhes,Ágnes Báthori,Edit Hajdú,Gyula Pokorny,László Kovács,Edit Urbán
Despite the development in the identification of Nocardia spp., common challenges exist in the laboratory diagnosis and management of nocardiosis. We report two cases of disseminated nocardiosis in a patient with hematologic disorder and in a patient with systemic lupus erythematosus, where the cooperation between various specialists was essential to set up the adequate diagnosis of disseminated nocardiosis
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Optimization of desferrioxamine E production by Streptomyces parvulus. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-31 Tamás Gáll,Gábor Lehoczki,Gyöngyi Gyémánt,Tamás Emri,Zsuzsa M Szigeti,György Balla,József Balla,István Pócsi
Siderophores are produced by a number of microbes to capture iron with outstandingly high affinity, which property also generates biomedical and industrial interests. Desferrioxamine E (DFO-E) secreted by streptomycetes bacteria can be an ideal candidate for iron chelation therapy, which necessitates its cost-effective production for in vitro and animal studies. This study focused on the optimization
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Untypeable hepatitis C virus subtypes in Pakistan: A neglected section. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-31 Abdul Waheed Khan,Zeeshan Nasim,Fazli Zahir,Shahid Ali,Abid Ali,Aqib Iqbal,Iqbal Munir
Diagnostically untypeable subtypes contribute a considerable percent of hepatitis C virus (HCV) subtypes in Pakistan. In the present study, chronically infected HCV patients with known viremia were subjected to HCV genotyping. Among the total retrieved samples, 92.7% (64/69) were found typeable while 7.24% (5/69) were diagnostically untypeable. In conclusion, the presence of large number of untypeable
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Identification of virulence genes carried by bacteriophages obtained from clinically isolated methicillin-resistant Staphylococcus aureus. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-31 Djursun Karasartova,Zeynep Burcin Cavusoglu,Buse Turegun,Murat T Ozsan,Fikret Şahin
Bacteriophages play an important role in the pathogenicity of Staphylococcus aureus (S. aureus) either by carrying accessory virulence factors or several superantigens. Despite their importance, there are not many studies showing the actual distribution of the virulence genes carried by the prophages obtained from the clinically isolated Staphylococcus. In this study, we investigated prophages obtained
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Molecular detection of aminoglycoside-modifying enzyme genes in Acinetobacter baumannii clinical isolates. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-16 Mohsen Heidary,Alireza Salimi Chirani,Saeed Khoshnood,Gita Eslami,Seyyed Mohammad Atyabi,Habibollah Nazem,Mohammad Fazilati,Ali Hashemi,Saleh Soleimani
Acinetobacter baumannii is a major opportunistic pathogen in healthcare settings worldwide. In Iran, there are only few reports on the prevalence of aminoglycoside resistance genes among A. baumannii isolates. The aim of this study was to investigate the existence of aminoglycoside-modifying enzyme (AME) genes from A. baumannii strains collected at a university teaching hospital in Iran. One hundred
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Antimicrobial resistance in Enterococcus strains isolated from healthy domestic dogs. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-15 Fabrizio Bertelloni,Claudia Salvadori,Giulia Lotti,Domenico Cerri,Valentina Virginia Ebani
Enterococci are opportunistic bacteria that cause severe infections in animals and humans, capable to acquire, express, and transfer antimicrobial resistance. Susceptibility to 21 antimicrobial agents was tested by the disk diffusion method in 222 Enterococcus spp. strains isolated from the fecal samples of 287 healthy domestic dogs. Vancomycin and ampicillin minimum inhibitory concentrations (MICs)
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Hormone (ACTH, T3) content of immunophenotyped lymphocyte subpopulations. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-12 Éva Pállinger,Gergely Attila Kiss,György Csaba
Cells of the immune system synthesize, store, and secrete polypeptide and amino acid type hormones, which also influence their functions, having receptors for different hormones. In the present experiment immunophenotyped immune cells isolated from bone marrow, thymus, and peritoneal fluid of mice were used for demonstrating the adrenocorticotropic hormone (ACTH) and triiodothyronine (T3) hormone production
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Composition of endophytic fungal community associated with leaves of maize cultivated in south Brazilian field. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-12 Vivian J Szilagyi-Zecchin,Douglas Adamoski,Renata Rodrigues Gomes,Mariangela Hungria,Angela C Ikeda,Vanessa Kava-Cordeiro,Chirlei Glienke,Lygia V Galli-Terasawa
The objective of this study was to conduct a survey about fungi associated with leaves from two different maize plant lineages and to analyze their microbiota diversity. Isolated fungi were identified by morphological analysis and molecular taxonomy was performed using ITS1-5.8S-ITS2 rDNA. About 27 fungi morphotypes were obtained, 15 of them were from the first maize lineage. About 86.7% of the individuals
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Full-length VP2 gene analysis of canine parvovirus reveals emergence of newer variants in India. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-12 Mangadevi Nookala,Hirak Kumar Mukhopadhyay,Amsaveni Sivaprakasam,Brindhalakshmi Balasubramanian,Prabhakar Xavier Antony,Jacob Thanislass,Mouttou Vivek Srinivas,Raghavan Madhusoodanan Pillai
The canine parvovirus (CPV) infection is a highly contagious and serious enteric disease of dogs with high fatality rate. The present study was taken up to characterize the full-length viral polypeptide 2 (VP2) gene of CPV of Indian origin along with the commercially available vaccines. The faecal samples from parvovirus suspected dogs were collected from various states of India for screening by PCR
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Effects of hemin, CO2, and pH on the branching of Candida albicans filamentous forms. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-12 Ágnes Jakab,Károly Antal,Tamás Emri,Imre Boczonádi,Alexandra Imre,Enikő Gebri,László Majoros,Walter Péter Pfliegler,Máté Szarka,György Balla,József Balla,István Pócsi
Morphological transitions of wild-type and oxidative stress-tolerant Candida albicans strains were followed in the RPMI-FBS culture medium at pH values and CO2 levels characteristic for the anatomical niches inhabited by this opportunistic human pathogen fungus, including the oral cavity as well as the intestinal and vaginal lumens. Selected cultures were also supplemented with hemin modeling bleedings
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Detection of acrA, acrB, aac(6')-Ib-cr, and qepA genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-12 Mohsen Heidary,Aghil Bahramian,Ali Hashemi,Mehdi Goudarzi,Vahid Fallah Omrani,Gita Eslami,Hossein Goudarzi
The distribution of drug resistance among clinical isolates of Escherichia coli and Klebsiella pneumoniae has limited the therapeutic options. The aim of this study was to report the prevalence of quinolone resistance genes among E. coli and K. pneumoniae clinical strains isolated from three educational hospitals of Tehran, Iran.
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Differences in MRSA prevalence and resistance patterns in a tertiary center before and after joining an international program for surveillance of antimicrobial resistance. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-08 Olivera Djuric,Snezana Jovanovic,Branka Stosovic,Tanja Tosic,Milica Jovanovic,Naomi Nartey,Jovana Todorovic,Ljiljana Markovic-Denic
Methicillin-resistant Staphylococcus aureus (MRSA) emerged as one of the most important causes of hospital-acquired bloodstream infections (BSIs), especially the multidrug resistant clones. The aim of the present study was to compare prevalence and resistance patterns of MRSA bacteremia in the major tertiary-care academic and referral center in Serbia before and after implementing an active antimicrobial
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Enhanced survival but not amplification of Francisella spp. in the presence of free-living amoebae. Acta Microbiol. Immunol. Hung. (IF 1.086) Pub Date : 2016-12-08 Helen Y Buse,Frank W Schaefer,Eugene W Rice
Transmission of Francisella tularensis, the etiologic agent of tularemia, has been associated with various water sources. Survival of many waterborne pathogens within free-living amoeba (FLA) is well documented; however, the role of amoebae in the environmental persistence of F. tularensis is unclear. In this study, axenic FLA cultures of Acanthamoeba castellanii, Acanthamoeba polyphaga, and Vermamoeba
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