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Pulmonary Vein Intervention for Severe Pulmonary Vein Stenosis After Atrial Fibrillation Ablation ― A Retrospective Cohort Study ― Circ. J. (IF 3.3) Pub Date : 2024-03-16 Kensuke Yokoi, Tomonori Katsuki, Takanori Yamaguchi, Toyokazu Otsubo, Yoshimitsu Soga, Kenichi Hiroshima, Shinjo Sonoda, Koichi Node
Background: Pulmonary vein (PV) stenosis (PVS) is a serious complication of atrial fibrillation (AF) ablation. The objective of this study was to describe interventional treatments for PVS after AF ablation and long-term outcomes in Japanese patients. Methods and Results: This multicenter retrospective observational study enrolled 30 patients (26 [87%] male; median age 55 years) with 56 severe PVS
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The Absorb GT1 Bioresorbable Vascular Scaffold System ― 5-Year Post-Market Surveillance Study in Japan ― Circ. J. (IF 3.3) Pub Date : 2024-03-13 Masato Nakamura, Nobuaki Suzuki, Kenshi Fujii, Jungo Furuya, Tomohiro Kawasaki, Takumi Kimura, Tomohiro Sakamoto, Kengo Tanabe, Hajime Kusano, Kelly A. Stockelman, Ken Kozuma
Background: The 1-year clinical outcomes of the Absorb GT1 Japan post-market surveillance (PMS) suggested that an appropriate intracoronary imaging-guided bioresorbable vascular scaffold (BVS) implantation technique may reduce the risk of target lesion failure (TLF) and scaffold thrombosis (ST) associated with the Absorb GT1 BVS. The long-term outcomes through 5 years are now available. Methods and Results:
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Optimizing Percutaneous Mitral Valvuloplasty for Rheumatic Mitral Stenosis ― Clinical Significance of Changes in Mitral Valve Area ― Circ. J. (IF 3.3) Pub Date : 2024-03-12 Kyu-Yong Ko, Iksung Cho, Dae-Young Kim, Hee Jeong Lee, Kyungeun Ha, Seo-Yeon Gwak, Kyu Kim, William Dowon Kim, Seon-Hwa Lee, Ji Won Seo, In-Cheol Kim, Kang-Un Choi, Hojeong Kim, Jang-Won Son, Chi Young Shim, Jong-Won Ha, Geu-Ru Hong
Background: Percutaneous mitral valvuloplasty (PMV) is a standard treatment for severe rheumatic mitral stenosis (RMS). However, the prognostic significance of the change in mitral valve area (∆MVA) during PMV is not fully understood. Methods and Results: This study analyzed data from the Multicenter mitrAl STEnosis with Rheumatic etiology (MASTER) registry, which included 3,140 patients with severe
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Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity ― A Prospective Cohort Study ― Circ. J. (IF 3.3) Pub Date : 2024-03-08 Keiko Inoue, Tomoko Machino-Ohtsuka, Yoko Nakazawa, Noriko Iida, Rumi Sasamura, Hiroko Bando, Shigeru Chiba, Nobutaka Tasaka, Tomoko Ishizu, Nobuyuki Murakoshi, Dongzhu Xu, Ikuo Sekine, Kazuko Tajiri
Background: In the present study, we aimed to investigate whether early cardiac biomarker alterations and echocardiographic parameters, including left atrial (LA) strain, can predict anthracycline-induced cardiotoxicity (AIC) and thus develop a predictive risk score. Methods and Results: The AIC registry is a prospective, observational cohort study designed to gather serial echocardiographic and biomarker
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Home Treatment for Active Cancer Patients With Low-Risk Pulmonary Embolism ― A Predetermined Companion Report From the ONCO PE Trial ― Circ. J. (IF 3.3) Pub Date : 2024-03-08 Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Tatsuhiro Shibata, Yuji Nishimoto, Yoshito Ogihara, Kosuke Doi, Maki Oi, Taro Shiga, Daisuke Sueta, Kitae Kim, Yasuhiro Tanabe, Norimichi Koitabashi, Takuma Takada, Satoshi Ikeda, Hitoshi Nakagawa, Takayuki Mitsuhashi, Masaaki Shoji, Jiro Sakamoto, Shinji Hisatake, Yutaka Ogino, Masashi Fujita, Naohiko Nakanishi, Tomohiro
Background: Patients with appropriately selected low-risk pulmonary embolism (PE) can be treated at home, although it has been controversial whether applies to patients with cancer, who are considered not to be at low risk. Methods and Results: The current predetermined companion report from the ONCO PE trial evaluated the 3-month clinical outcomes of patients with home treatment and those with in-hospital
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Overview of the 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023) ― New Challenge With Next Generation ― Circ. J. (IF 3.3) Pub Date : 2024-03-07 Tetsuya Matoba, Yasuhiro Nakano, Shunsuke Katsuki, Tomomi Ide, Shouji Matsushima, Takeo Fujino, Toru Hashimoto, Keisuke Shinohara, Kohtaro Abe, Kazuya Hosokawa, Takafumi Sakamoto, Ichiro Sakamoto, Takamori Kakino, Ayako Ishikita, Akiko Nishizaki, Kazuo Sakamoto, Susumu Takase, Tomomi Nagayama, Takeshi Tohyama, Takuya Nagata, Shintaro Kinugawa, Hiroyuki Tsutsui
The 87thAnnual Meeting of the Japanese Circulation Society (JCS2023) was held in March 2023 in Fukuoka, Japan, marking the first in-person gathering after the COVID-19 pandemic. With the theme of “New Challenge With Next Generation” the conference emphasized the development of future cardiovascular leaders and technologies such as artificial intelligence (AI). Notable sessions included the Mikamo Lecture
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Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair From the J-MITRA Registry Data Circ. J. (IF 3.3) Pub Date : 2024-03-06 Teruhiko Imamura, Michikazu Nakai, Yoshitaka Iwanaga, Yoko Sumita, Misato Tao, Yohei Ohno, Kentaro Hayashida, Yoshihiro Morino, Yoshihiro Seo, Yoshikatsu Saiki, Toshihisa Anzai, Koichi Toda, Goro Matsumiya, Kazuhiro Yamamoto, Kenichi Hirata, Koichiro Kinugawa, on behalf of J-MITRA Investigators
Background: The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese
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Real-World Clinical Profile of Patients Prescribed Evolocumab in Japan Circ. J. (IF 3.3) Pub Date : 2024-03-01 Feng Sheng, Alex Y. Wang, Kazumasa Miyawaki, Takahiro Tsuchiya, Nobuhiro Osada, Russell Miller, Ziyang Fu, Tomonori Okamura
Background: Real-world utilization data for evolocumab, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be introduced in Japan in 2016, to date are limited. This study aimed to clarify the current real-world patient user profiles of evolocumab based on large-scale health claims data. Methods and Results: This retrospective database study examined patients from a health
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Multisystemic Inflammation Influences Prognosis in Fulminant Lymphocytic Myocarditis Circ. J. (IF 3.3) Pub Date : 2024-03-01 Hiroaki Kawano, Satoshi Ikeda, Koshiro Kanaoka, Shuntaro Sato, Ryo Eto, Yuki Ueno, Kenji Onoue, Yoshihiko Saito, Koji Maemura, the Japanese Registry of Fulminant Myocarditis Investigators
Background: Multisystem inflammatory syndrome (MIS) is a hyperinflammatory shock associated with cardiac dysfunction and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, there are no reports on using MIS criteria, such as multisystemic inflammation (MSI) in fulminant myocarditis, without SARS-CoV-2 infection. This study investigated the differences in clinical characteristics
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Clinical Features of 544 Patients With Ruptured Aortic Aneurysm ― A Report From the Tokyo Acute Aortic Super Network Database ― Circ. J. (IF 3.3) Pub Date : 2024-02-28 Koichi Akutsu, Hideaki Yoshino, Tomoki Shimokawa, Hitoshi Ogino, Takashi Kunihara, Toshiyuki Takahashi, Michio Usui, Kazuhiro Watanabe, Manabu Yamasaki, Takeshiro Fujii, Mitsuhiro Kawata, Yoshinori Watanabe, Takeshi Yamamoto, Shun Kohsaka, Ken Nagao, Morimasa Takayama
Background: Epidemiological data on ruptured aortic aneurysms from large-scale studies are scarce. The aims of this study were to: clarify the clinical course of ruptured aortic aneurysms; identify aneurysm site-specific therapies and outcomes; and determine the clinical course of patients receiving conservative therapy. Methods and Results: Using the Tokyo Acute Aortic Super Network database, we retrospectively
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Potential Clinical Implications of Senotherapies for Cardiovascular Disease Circ. J. (IF 3.3) Pub Date : 2024-02-22 Masayoshi Suda, Goro Katsuumi, Tamar Tchkonia, James L. Kirkland, Tohru Minamino
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset and progression of CVDs. In recent years, therapies targeting senescent cells (senotherapies), particularly senolytics that selectively eliminate senescent cells, have been developed and show promise for treating geriatric syndromes and age-associated
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Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population ― NIPPON DATA90 ― Circ. J. (IF 3.3) Pub Date : 2024-02-20 Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura, for the NIPPON DATA90 Research Group
Background: Deviations of hemoglobin from normal levels may be a factor in cardiovascular disease (CVD) risk; however, conclusive evidence is lacking. In addition, preclinical conditions may influence hemoglobin concentrations, but studies focusing on reverse causation are limited. Thus, we examined the relationship between hemoglobin concentrations and CVD mortality risk, considering reverse causation
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Organ Damage and Quality of Life in Takayasu Arteritis ― Evidence From a National Registry Analysis ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Hajime Yoshifuji, Yoshikazu Nakaoka, Haruhito A. Uchida, Takahiko Sugihara, Yoshiko Watanabe, Sohei Funakoshi, Mitsuaki Isobe, Masayoshi Harigai, Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS)
Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan’s Intractable Disease Registry. Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity
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One-Year Clinical Outcomes and Prognostic Factors Following Revascularization in Patients With Acute Limb Ischemia ― Results From the RESCUE ALI Study ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Michinao Tan, Mitsuyoshi Takahara, Takuya Haraguchi, Daiki Uchida, Yutaka Dannoura, Tsuyoshi Shibata, Shuko Iwata, Nobuyoshi Azuma
Background: Acute limb ischemia (ALI) is a limb- and life-threatening condition and urgent treatment including revascularization should be offered to patients unless the limb is irreversibly ischemic. The aim of this study was to investigate 1-year clinical outcomes and prognostic factors following revascularization in patients with ALI. Methods and Results: A retrospective, multicenter, nonrandomized
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Benign Prostatic Hyperplasia and Incident Cardiovascular Disease Circ. J. (IF 3.3) Pub Date : 2024-02-22 Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Katsuhito Fujiu, Taisuke Jo, Norifumi Takeda, Atsushi Tanaka, Koichi Node, Hiroyuki Morita, Hideo Yasunaga, Issei Komuro
Background: Data regarding the relationship between benign prostatic hyperplasia (BPH) and incident cardiovascular disease (CVD) are scarce. We aimed to clarify the association of BPH with the risk of developing CVD using a nationwide epidemiological database. Methods and Results: This retrospective observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2022, including
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Comprehensive Risk Assessment in Patients With Pulmonary Arterial Hypertension Referred for Lung Transplantation Circ. J. (IF 3.3) Pub Date : 2024-02-23 Satoshi Ishii, Masaru Hatano, Shun Minatsuki, Kazutoshi Hirose, Akihito Saito, Hiroki Yagi, Mai Shimbo, Katsura Soma, Chihiro Konoeda, Masaaki Sato, Jun Nakajima, Issei Komuro
Background: Whether comprehensive risk assessment predicts post-referral outcome in patients with pulmonary arterial hypertension (PAH) referred for lung transplantation (LT) in Japan is unknown. Methods and Results: We retrospectively analyzed 52 PAH patients referred for LT. Risk status at referral was assessed using 3- and 4-strata models from the 2022 European Society of Cardiology and European
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Population-Based Study of the Incidence and Mortality Rate of Acute Aortic Dissection Circ. J. (IF 3.3) Pub Date : 2024-02-22 Shuji Moriyama, Masahiko Hara, Takafumi Hirota, Kosuke Nakata, Hideki Doi, Toshiyuki Matsumura, Yushi Araki, Yukihiro Inomata, Toshihiro Fukui
Background: Acute aortic dissection (AAD) has high morbidity and a high fatality rate for a cardiovascular disease. Recent studies suggested that the incidence of AAD is increasing. However, the actual incidence and mortality rates of AAD are not well known. This study investigated the current epidemiology of AAD within the Yatsushiro medical jurisdictional area. Methods and Results: A population-based
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Outcomes of Endovascular Treatment for Infective Aortic Aneurysms ― A Multicenter Retrospective Study ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Chih-Chun Lee, Dong-Yi Chen, Yi-Hsin Chan, Victor Chien-Chia Wu, Yu-Ting Cheng, Kuo-Chun Hung, Chia-Pin Lin, Ying-Chang Tung, Fu-Chih Hsiao, Jih-Kai Yeh, Pao-Hsien Chu, Shao-Wei Chen
Background: In Taiwan, infective native aortic aneurysms (INAAs) are relatively common, so the aim of present study was to demonstrate the comparative outcomes of endovascular repair for thoracic and abdominal INAAs. Methods and Results: Patients with naïve thoracic or abdominal INAAs managed with endovascular repair between 2001 and 2018 were included in this multicenter retrospective cohort. The
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Demographic Traits, Clinical Status, and Comorbidities of Patients With Thromboangiitis Obliterans in Japan Circ. J. (IF 3.3) Pub Date : 2024-02-22 Yoshiko Watanabe, Yuuki Shimizu, Takuya Hashimoto, Toru Iwahashi, Kunihiro Shigematsu, Yoshikazu Nakaoka, Masayoshi Harigai, Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS)
Background: The latest demographics, clinical and living conditions, and comorbidities of patients with thromboangiitis obliterans (TAO) in Japan are unknown. Methods and Results: We conducted a retrospective cross-sectional survey using the annual database of the Japanese Ministry of Health, Labour and Welfare medical support system for patients with TAO between April 2013 and March 2014. This study
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Prognostic Impact of Reduced Left Ventricular Ejection Fraction After Endovascular Therapy for Lower Extremities Circ. J. (IF 3.3) Pub Date : 2024-02-22 Keiko Fukino, Daisuke Ueshima, Tetsuo Yamaguchi, Atsushi Mizuno, Kazuki Tobita, Kenji Suzuki, Naotaka Murata, Kentaro Jujo, Takahide Kodama, Fumitaka Nakamura, Michiaki Higashitani
Background: The mechanism underlying a poor prognosis in patients with lower-extremity artery disease (LEAD) with heart failure is unknown. We examined the prognostic impact of the left ventricular ejection fraction (LVEF) in patients with LEAD who underwent endovascular therapy (EVT). Methods and Results: From August 2014 to August 2016, 2,180 patients with LEAD (mean age, 73.2 years; male, 71.9%)
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Deformed Popliteal Artery Due to Highly Flexed Knee Position Can Cause Kinks, Creating an Unfavorable Hemodynamic State Circ. J. (IF 3.3) Pub Date : 2024-02-22 Hiroyuki Nagita, Chen Wang, Hiroyuki Saigusa, Katsuyuki Hoshina, Masamitsu Suhara, Marie Oshima
Background: Endovascular treatment devices of the femoropopliteal artery have evolved, improving clinical results. However, the effects of dynamic changes in the popliteal artery during knee flexion have not been sufficiently investigated. In this study we performed a 3-dimensional analysis to clarify the dynamic changes in the popliteal artery during knee flexion and their effects on hemodynamics
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Efficacy and Safety of Warfarin for the Treatment of Venous Thromboembolism ― A Multicenter Prospective Observational Cohort Study in Japan (AKAFUJI Study) ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Mashio Nakamura, Satoshi Tamaru, Shigeki Hirooka, Atsushi Hirayama, Akihiro Tsuji, Mitsuhiro Hirata, Mitsuru Munemasa, Izumi Nakagawa, Masahiro Toshima, Hiroaki Shimokawa, Yuki Nishimura, Toru Ogura, Takeshi Yamamoto, Hirono Satokawa, Toru Obayashi, Norikazu Yamada, on behalf of the AKAFUJI Study Investigators
Background: A large-scale prospective study of the efficacy and safety of warfarin for the treatment of venous thromboembolism (VTE) has not been conducted in Japan. Therefore, we conducted a real-world prospective multicenter observational cohort study (AKAFUJI Study; UMIN000014132) to investigate the efficacy and safety of warfarin for VTE. Methods and Results: Between May 2014 and March 2017, 352
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Clinical Characteristics and Outcomes of Patients With Venous Thromboembolism Receiving Edoxaban in the Real World Circ. J. (IF 3.3) Pub Date : 2024-02-22 Yugo Yamashita, Toshiki Fukasawa, Chikashi Takeda, Masato Takeuchi, Koh Ono, Koji Kawakami
Background: The effectiveness and safety of edoxaban for venous thromboembolism (VTE) in unselected real-world patients have not been fully evaluated. Methods and Results: In the Japanese nationwide administrative database, we identified 6,262 VTE patients in whom edoxaban was initiated; these patients were divided into 3 groups based on their index doses: 15 mg/day (n=235), 30 mg/day (n=4,532), and
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Magnetic Resonance Imaging-Guided Intravenous Thrombolysis in Cardioembolic Stroke Patients With Unknown Time of Onset ― Subanalysis of the THAWS Randomized Control Trial ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Naoya Yamazaki, Masatoshi Koga, Ryosuke Doijiri, Manabu Inoue, Kaori Miwa, Sohei Yoshimura, Mayumi Fukuda-Doi, Junya Aoki, Koko Asakura, Makoto Sasaki, Takanari Kitazono, Kazumi Kimura, Kazuo Minematsu, Haruko Yamamoto, Masafumi Ihara, Kazunori Toyoda, for the THAWS Trial Investigators
Background: We investigated the clinical effect of intravenous thrombolysis using a magnetic resonance imaging (MRI)-guided approach in cardioembolic stroke (CE) patients with unknown time of onset. Methods and Results: This subanalysis of the THAWS trial assessed the efficacy and safety of alteplase 0.6 mg/kg in CE patients with unknown time of onset and showing diffusion-weighted imaging–fluid-attenuated
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Scoping Review of Screening and Assessment Tools for Social Determinants of Health in the Field of Cardiovascular Disease Circ. J. (IF 3.3) Pub Date : 2024-02-22 Takahiro Suzuki, Atsushi Mizuno, Haruyo Yasui, Satsuki Noma, Takashi Ohmori, Jeffrey Rewley, Fujimi Kawai, Takeo Nakayama, Naoki Kondo, Yayoi Tetsuou Tsukada
Background: Despite the importance of implementing the concept of social determinants of health (SDOH) in the clinical practice of cardiovascular disease (CVD), the tools available to assess SDOH have not been systematically investigated. We conducted a scoping review for tools to assess SDOH and comprehensively evaluated how these tools could be applied in the field of CVD. Methods and Results: We
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Estimated Pulse Wave Velocity Predicts All-Cause and Cardiovascular-Cause Mortality in Individuals With Hypertension ― Findings From a National Health and Nutrition Examination Study 1999–2018 ― Circ. J. (IF 3.3) Pub Date : 2024-02-22 Yi Shi, Li-Da Wu, Xiao-Hua Feng, Jun-Yan Kan, Chao-Hua Kong, Zhi-Yu Ling, Jun-Xia Zhang, Shao-Liang Chen
Background: This study aimed to investigate the association between estimated pulse wave velocity (ePWV) and mortality outcomes among individuals with hypertension. Methods and Results: Based on the National Health and Nutrition Examination Survey (NHANES) 1999–2018, a total of 14,396 eligible participants with hypertension were enrolled. The ePWV was calculated using the equation based on blood pressure
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Exosomal miR206 Secreted From Growing Muscle Promotes Angiogenic Response in Endothelial Cells Circ. J. (IF 3.3) Pub Date : 2024-02-22 Hiroya Hayashi, Yasuhiro Izumiya, Toshifumi Ishida, Yuichiro Arima, Ou Hayashi, Minoru Yoshiyama, Kenichi Tsujita, Daiju Fukuda
Background: Resistance exercise is beneficial in patients with lower extremity arterial disease. Muscle-derived exosomes contain many types of signaling molecules, including microRNAs (miRNAs). Here, we tested the hypothesis that exosomal miRNAs secreted by growing muscles promote an angiogenic response in endothelial cells (ECs). Methods and Results: Skeletal muscle-specific conditional Akt1 transgenic
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Importance of B-Type Natriuretic Peptide in the Detection of Patients With Structural Heart Disease in a Primary Care Setting Circ. J. (IF 3.3) Pub Date : 2024-02-17 Wataru Fujimoto, Susumu Odajima, Hiroshi Okamoto, Masamichi Iwasaki, Manabu Nagao, Akihide Konishi, Masakazu Shinohara, Ryuji Toh, Masanori Okuda, Ken-ichi Hirata, Hidekazu Tanaka
Background: Early detection and intervention for preclinical heart failure (HF) are crucial for restraining the potential increase in patients with HF. Thus, we designed and conducted a single-center retrospective cohort study to confirm the efficacy of B-type natriuretic peptide (BNP) for the early detection of preclinical HF in a primary care setting. Methods and Results: We investigated 477 patients
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Feasibility of Auto-Quantified Epicardial Adipose Tissue in Predicting Atrial Fibrillation Recurrence After Catheter Ablation Circ. J. (IF 3.3) Pub Date : 2024-02-14 Ling Kuo, Guan-Jie Wang, Shih-Ling Chang, Yenn-Jiang Lin, Fa-Po Chung, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Ta-Chuan Tuan, Jo-Nan Liao, Ting-Yung Chang, Chin-Yu Lin, Chih-Min Liu, Shin-Huei Liu, Ming-Ren Kuo, Guan-Yi Li, Yu-Shan Huang, Cheng-I Wu, Shih-Ann Chen, Chia-Feng Lu
Background: The aim of this study was to build an auto-segmented artificial intelligence model of the atria and epicardial adipose tissue (EAT) on computed tomography (CT) images, and examine the prognostic significance of auto-quantified left atrium (LA) and EAT volumes for AF. Methods and Results: This retrospective study included 334 patients with AF who were referred for catheter ablation (CA)
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Efficacy of Native T1 Mapping for Patients With Non-Ischemic Cardiomyopathy and Ventricular Functional Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair Circ. J. (IF 3.3) Pub Date : 2024-02-08 Hiroshi Tsunamoto, Hiroyuki Yamamoto, Akiko Masumoto, Yasuyo Taniguchi, Nobuyuki Takahashi, Tetsuari Onishi, Tomofumi Takaya, Hiroya Kawai, Ken-ichi Hirata, Hidekazu Tanaka
Background: We investigated the efficacy of left ventricular (LV) myocardial damage by native T1mapping obtained with cardiac magnetic resonance (CMR) for patients undergoing transcatheter edge-to-edge repair (TEER). Methods and Results: We studied 40 symptomatic non-ischemic heart failure (HF) patients and ventricular functional mitral regurgitation (VFMR) undergoing TEER. LV myocardial damage was
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Risk Factors of Long-Term Sequelae After Transcatheter Closure of Perimembranous Ventricular Septal Defect in Young Children Circ. J. (IF 3.3) Pub Date : 2024-02-08 Chia-Yi Chin, Chun-An Chen, Chun-Min Fu, Jui-Yu Hsu, Hsin-Chia Lin, Shuenn-Nan Chiu, Ya-Mei Chang, Chun-Wei Lu, Heng-Wen Chou, Shu-Chien Huang, Yih-Sharng Chen, Mei-Hwan Wu, Jou-Kou Wang, Ming-Tai Lin
Background: Complications arising from transcatheter closure of perimembranous ventricular septal defects (pmVSD) in children, such as residual shunts and aortic regurgitation (AR), have been observed. However, the associated risk factors remain unclear. This study identified risk factors linked with residual shunts and AR following transcatheter closure of pmVSD in children aged 2–12 years. Methods and Results:
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Risk Factors for Coronary Artery Complications After Prosthetic Pulmonary Valve Implantation in Patients With Congenital Heart Disease Circ. J. (IF 3.3) Pub Date : 2024-02-06 Hye Won Kwon, Mi Kyoung Song, Sang Yun Lee, Gi Beom Kim, Jae Gun Kwak, Sungkyu Cho, Woong-Han Kim, Eun Jung Bae
Background: Coronary artery complications (CACs) in patients who undergoing prosthetic pulmonary valve implantation for congenital heart disease can lead to fetal outcomes. However, the incidence of and risk factors for CACs in these patients remain unknown. Methods and Results: A retrospective cohort study was conducted on patients who underwent cardiac computed tomography or invasive coronary angiography
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Preoperative Prediction of Shock Impedance for Subcutaneous Implantable Cardioverter Defibrillator Using Chest Computed Tomography Circ. J. (IF 3.3) Pub Date : 2024-02-02 Akira Kasagawa, Ikutaro Nakajima, Yui Nakayama, Daisuke Togashi, Kenichi Sasaki, Hisao Matsuda, Tomoo Harada, Yoshihiro J Akashi
Background: High shock impedance is associated with conversion failure among patients with subcutaneous implantable cardioverter defibrillators (S-ICD). Currently, there is no preoperative assessment method for predicting high shock impedance. This study examined the efficacy of chest computed tomography (CT) as a preoperative evaluation tool to assess the shock impedance of S-ICDs. Methods and Results:
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Procedural Efficiencies and Clinical Outcomes for Transcatheter Device Closure of Perimembranous Ventricular Septal Defects With Different Waist-Length Occluders Circ. J. (IF 3.3) Pub Date : 2024-01-31 Diandong Jiang, Yuxin Zhang, Yingchun Yi, Lijian Zhao, Jianli Lv, Jing Wang, Yan Wang, Xiaofei Yang, Jianjun Zhang, Bo Han
Background: Potential differences in complications and/or long-term outcomes of perimembranous ventricular septal defect (pmVSD) closures with 3-mm waist vs. 4-mm waist double-disk symmetrical occluders are not known. Methods and Results: A total of 395 consecutive pediatric patients with pmVSD recruited between January 2017 and March 2021 underwent successful transcatheter closure using symmetrical
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Impact of Sleep Apnea on Nocturnal Parasympathetic Activity in Atrial Fibrillation Patients After Catheter Ablation ― Implications for Heart Rate Variability Analysis ― Circ. J. (IF 3.3) Pub Date : 2024-01-27 Hibiki Iwakoshi, Yusuke C Asada, Mitsuko Nakata, Masahiro Makino, Jun Munakata, Nobunari Tomura, Satoshi Shimoo, Tetsuro Nishimura, Hirokazu Shiraishi, Satoaki Matoba, Keitaro Senoo
Background: The impact of sleep apnea (SA) on heart rate variability (HRV) in atrial fibrillation (AF) patients has not been investigated. Methods and Results: Of 94 patients who underwent AF ablation between January 2021 and September 2022, 76 patients who had a nocturnal Holter electrocardiography and polysomnography conducted simultaneously were included in the analysis. A 15-min duration of HRV
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Mitral Valve Repair vs. Replacement by Different Etiologies ― A Nationwide Population-Based Cohort Study ― Circ. J. (IF 3.3) Pub Date : 2024-01-27 Hsiu-An Lee, Feng-Cheng Chang, Jih-Kai Yeh, Ying-Chang Tung, Victor Chien-Chia Wu, Ming-Jer Hsieh, Chun-Yu Chen, Chi-Hsiao Yeh, Pao-Hsien Chu, Shao-Wei Chen
Background: When mitral valve (MV) surgery is indicated, repair is preferred over replacement; however, this preference is not supported by evidence from clinical trials. Furthermore, the benefits of MV repair may not be universal for all etiologies of MV disease. Methods and Results: This study identified a total of 18,428 patients who underwent MV repair (n=4,817) or MV replacement (n=13,611) during
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Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome Circ. J. (IF 3.3) Pub Date : 2024-01-25 Masanobu Ishii, Kyohei Marume, Michikazu Nakai, Soshiro Ogata, Ryota Kaichi, Sou Ikebe, Takayuki Mori, Soichi Komaki, Hiroaki Kusaka, Reiko Toida, Kazumasa Kurogi, Hisao Ogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Nobuyasu Yamamoto, Kenichi Tsujita
Background:Cancer is a known prognostic factor in patients with acute coronary syndrome (ACS), but few risk assessments of cancer development after ACS have been established. Methods and Results:Of the 573 consecutive ACS admissions between January 2015 and March 2018 in Nobeoka City, Japan, 552 were analyzed. Prevalent cancer was defined as a treatment history of cancer, and incident cancer as post-discharge
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Comparison of Edoxaban and Warfarin for the Treatment of Cancer-Associated Venous Thromboembolism ― A Retrospective Observational Study ― Circ. J. (IF 3.3) Pub Date : 2024-01-25 Hitoshi Goto, Michihisa Umetsu, Daijirou Akamatsu, Hirofumi Sugawara, Ken Tsuchida, Yoshitaro Yoshida, Shunya Suzuki, Takashi Kamei
Background:Because anticoagulant drugs for ambulatory patients with cancer-associated venous thromboembolism (CAT) are limited to warfarin and direct oral anticoagulants (DOACs) in Japan, it is important to assess the outcomes of both drugs. Methods and Results:We retrospectively assessed the outcomes of CAT patients who were treated with warfarin or edoxaban between 2011 and 2017. The assessment was
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Shared and Reciprocal Mechanisms Between Heart Failure and Cancer ― An Emerging Concept of Heart-Cancer Axis ― Circ. J. (IF 3.3) Pub Date : 2024-01-25 Hiroshi Kadowaki, Hiroshi Akazawa, Akito Shindo, Tomomi Ueda, Junichi Ishida, Issei Komuro
Epidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system
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Do Pathophysiologic Mechanisms Linking Unhealthy Lifestyle to Cardiovascular Disease and Cancer Imply Shared Preventive Measures? ― A Critical Narrative Review ― Circ. J. (IF 3.3) Pub Date : 2024-01-25 Stefania Angela Di Fusco, Antonella Spinelli, Lorenzo Castello, Gaetano Marino, Ilaria Maraschi, Michele Massimo Gulizia, Domenico Gabrielli, Furio Colivicchi
Growing evidence has shown a bidirectional link between the cardiologic and oncologic fields. Several investigations support the role of unhealthy behaviors as pathogenic factors of both cardiovascular disease and cancer. We report epidemiological and research findings on the pathophysiological mechanisms linking unhealthy lifestyle to cardiovascular disease and cancer. For each unhealthy behavior
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Prognostic Effect of Incidental Pulmonary Embolism on Long-Term Mortality in Cancer Patients Circ. J. (IF 3.3) Pub Date : 2024-01-25 Tatsuya Nishikawa, Takeshi Fujita, Toshitaka Morishima, Sumiyo Okawa, Terutaka Hino, Taku Yasui, Wataru Shioyama, Toru Oka, Isao Miyashiro, Masashi Fujita
Background:The effect of incidental pulmonary embolism (PE) on long-term prognosis in cancer patients is unclear. This study assessed the characteristics of cancer and venous thromboembolism (VTE) and the effect of incidental PE identified by oncologists on long-term survival of patients with cancer. Methods and Results:This single-center, retrospective, cohort study used hospital-based cancer registry
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Impact of a Cancer History on Cardiovascular Events Among Patients With Myocardial Infarction Who Received Revascularization Circ. J. (IF 3.3) Pub Date : 2024-01-25 Taro Takeuchi, Shumpei Kosugi, Yasunori Ueda, Kuniyasu Ikeoka, Haruya Yamane, Kohtaro Takayasu, Takuya Ohashi, Takashi Fukushima, Kohei Horiuchi, Takashi Iehara, Mai Sakamoto, Kazuho Ukai, Shinya Minami, Yuuki Mizumori, Naoya Muraoka, Masayuki Nakamura, Tatsuhisa Ozaki, Tsuyoshi Mishima, Haruhiko Abe, Koichi Inoue, Yasushi Matsumura
Background: It remains controversial whether a cancer history increases the risk of cardiovascular (CV) events among patients with myocardial infarction (MI) who undergo revascularization. Methods and Results: Patients who were confirmed as type 1 acute MI (AMI) by coronary angiography were retrospectively analyzed. Patients who died in hospital or those not undergoing revascularization were excluded
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Both New-Onset and Pre-Existing Hypertension Indicate Favorable Clinical Outcomes in Patients Treated With Anti-Vascular Endothelial Growth Factor Therapy Circ. J. (IF 3.3) Pub Date : 2024-01-25 Shohei Moriyama, Michinari Hieda, Megumi Kisanuki, Shotaro Kawano, Taku Yokoyama, Mitsuhiro Fukata, Hitoshi Kusaba, Toru Maruyama, Eishi Baba, Koichi Akashi, Haruhisa Fukuda
Background: Hypertension is a frequent adverse event caused by vascular endothelial growth factor signaling pathway (VSP) inhibitors. However, the impact of hypertension on clinical outcomes during VSP inhibitor therapy remains controversial. Methods and Results: We reviewed 3,460 cancer patients treated with VSP inhibitors from the LIFE Study database, comprising Japanese claims data between 2016
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Assessment of Pazopanib-Related Heart Failure in Patients With Advanced Soft Tissue Sarcoma ― A Single Institute Analysis ― Circ. J. (IF 3.3) Pub Date : 2024-01-25 Xiaofei Wang, Kenji Nakano, Taro Shiga, Akihiro Ohmoto, Takuya Oyakawa, Aya Ebihara, Yasuyoshi Sato, Naoki Fukuda, Masatoshi Nishizawa, Tsuya Urasaki, Makiko Ono, Mayu Yunokawa, Junichi Tomomatsu, Shunji Takahashi
Background:Heart failure (HF) is one of the potential adverse events of pazopanib treatment for soft tissue sarcoma (STS), but detailed reports of such HF cases are scarce. This study determined the incidence and risk factors of HF following pazopanib treatment for STS at our Institute and the clinical outcomes. Methods and Results:This study retrospectively analyzed the cases of STS patients treated
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Mortality, Recurrent Thromboembolism and Major Bleeding in Cancer-Associated and Non-Cancer Pulmonary Embolism Patients Treated With Direct Oral Anticoagulants Circ. J. (IF 3.3) Pub Date : 2024-01-25 Yoshihisa Nakano, Shiro Adachi, Ryo Imai, Masahiro Yoshida, Shigetake Shimokata, Toyoaki Murohara, Takahisa Kondo
Background:Pulmonary embolism (PE) is a potentially fatal form of venous thromboembolism (VTE). This study compares the mortality, incidence of recurrent VTE, and incidence of major bleeding between non-cancer and cancer-associated PE patients treated with direct oral anticoagulants (DOACs). Methods and Results:This was a retrospective, observational, single-center study involving 130 consecutive patients
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Sex Differences in Epidemiological Distribution and Outcomes of Surgical Mitral Valve Disease Circ. J. (IF 3.3) Pub Date : 2024-01-24 Feng-Cheng Chang, Chun-Yu Chen, Yi-Hsin Chan, Yu-Ting Cheng, Chia-Pin Lin, Victor Chien-Chia Wu, Kuo-Chun Hung, Pao-Hsien Chu, An-Hsun Chou, Shao-Wei Chen
Background: Mitral valve (MV) disease is the most common form of valvular heart disease. Findings that indicate women have a higher risk for unfavorable outcomes than men remain controversial. This study aimed to determine the sex-based differences in epidemiological distributions and outcomes of surgery for MV disease. Methods and Results: Overall, 18,572 patients (45.3% women) who underwent MV surgery
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Fifteen-Year Clinical Outcomes After Sirolimus-Eluting Stent Implantation Circ. J. (IF 3.3) Pub Date : 2024-01-24 Naoki Nishiura, Shunsuke Kubo, Chihiro Fujii, Yuki Shima, Akihiro Ikuta, Kohei Osakada, Takeshi Tada, Yasushi Fuku, Hiroyuki Tanaka, Kazushige Kadota
Background: Clinical outcomes after percutaneous coronary intervention have improved with the use of drug-eluting stents, but data beyond 10 years are limited. The purpose of this study was to evaluate the clinical outcomes of patients undergoing sirolimus-eluting stent implantation with follow-up beyond 10 years and to determine the impact of clinical and angiographic characteristics on long-term
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Pacemaker-Related Factors and Outcomes of Fontan Patients ― Impact of Paced QRS Duration ― Circ. J. (IF 3.3) Pub Date : 2024-01-23 Hyewon Shin, Jae Suk Baek, Mi Jin Kim, Seulgi Cha, Jeong Jin Yu
Background: Permanent pacemaker (PPM) implantation has been identified as a risk factor for morbidity and mortality after Fontan operation. This study investigated the factors associated with outcomes in patients with Fontan physiology who underwent PPM implantation. Methods and Results: We retrospectively reviewed 508 patients who underwent Fontan surgery at Asan Medical Center between September 1992
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Scoring System for Prediction of Left Ventricular Longitudinal Myocardial Dysfunction in Preclinical Heart Failure Patients Circ. J. (IF 3.3) Pub Date : 2024-01-19 Susumu Odajima, Makoto Nishimori, Hiroshi Okamoto, Ken-ichi Hirata, Hidekazu Tanaka
Background: Detection of left ventricular (LV) abnormalities is essential for patients with preclinical heart failure (HF) to delay progression to clinical HF. Global longitudinal strain (GLS) is a sensitive marker for the early occurrence of subtle abnormalities in LV function, but not all echocardiographic instruments can measure GLS. Methods and Results: We studied 853 preclinical HF patients to
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Guideline-Directed Medical Therapy for Elderly Patients With Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention ― Insights From a Retrospective Observational Study ― Circ. J. (IF 3.3) Pub Date : 2024-01-18 Kensaku Nishihira, Michikazu Nakai, Nehiro Kuriyama, Kosuke Kadooka, Yasuhiro Honda, Hiroki Emori, Keisuke Yamamoto, Shun Nishino, Takeaki Kudo, Kenji Ogata, Toshiyuki Kimura, Koichi Kaikita, Yoshisato Shibata
Background: The efficacy of guideline-directed medical therapy (GDMT) in the elderly remains unclear. This study evaluated the impact of GDMT (aspirin or a P2Y12inhibitor, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, β-blocker, and statin) at discharge on long-term mortality in elderly patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary
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Incidence of Hospitalization-Associated Disability in Older Patients With Heart Failure Circ. J. (IF 3.3) Pub Date : 2024-01-13 Tetsuya Takahashi, Kentaro Iwata, Tomoyuki Morisawa, Michitaka Kato, Yuji Kono, Masanobu Taya, Yuki Iida, Yoshinari Funami, Kentaro Kamiya, Koji Sakurada, Masakazu Saitoh
Background: This study determined the incidence of hospitalization-associated disability (HAD) and its characteristics in older patients with heart failure in Japan. Methods and Results: Ninety-six institutions participated in this nationwide multicenter registry study (J-Proof HF). From December 2020 to March 2022, consecutive heart failure patients aged ≥65 years who were prescribed physical rehabilitation
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In-Hospital Mortality in Patients With Cardiogenic Shock Requiring Veno-Arterial Extracorporeal Membrane Oxygenation With Concomitant Use of Impella vs. Intra-Aortic Balloon Pump ― A Retrospective Cohort Study Using a Japanese Claims-Based Database ― Circ. J. (IF 3.3) Pub Date : 2024-01-12 Manabu Nitta, Shintaro Nakano, Makoto Kaneko, Kiyohide Fushimi, Kiyoshi Hibi, Sayuri Shimizu
Background: Patients with refractory cardiogenic shock (CS) necessitating peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) often require an intra-aortic balloon pump (IABP) or Impella for unloading; however, comparative effectiveness data are currently lacking. Methods and Results: Using Diagnosis Procedure Combination data from approximately 1,200 Japanese acute care hospitals
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Impact of Long-Term Exercise-Based Cardiac Rehabilitation in Patients With Chronic Heart Failure ― A Systematic Review and Meta-Analysis ― Circ. J. (IF 3.3) Pub Date : 2024-01-12 Shuhei Yamamoto, Masatsugu Okamura, Yoshihiro J. Akashi, Shinya Tanaka, Masashi Shimizu, Yohei Tsuchikawa, Kohei Ashikaga, Kentaro Kamiya, Yuko Kato, Atsuko Nakayama, Shigeru Makita, Mitsuaki Isobe
Background: This study aimed to clarify the effects of exercise-based cardiac rehabilitation (CR) on patients with heart failure. Methods and Results: Patients were divided into groups according to intervention duration (<6 and ≥6 months). We searched for studies published up to July 2023 in Embase, MEDLINE, PubMed, and the Cochrane Library, without limitations on data, language, or publication status
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Radiofrequency Catheter Ablation for Atrial Fibrillation Patients on Hemodialysis (From the Kansai Plus Atrial Fibrillation Registry) ― Clinical Impact of Early Recurrence ― Circ. J. (IF 3.3) Pub Date : 2024-01-11 Naoaki Onishi, Kazuaki Kaitani, Yoshihisa Nakagawa, Atsushi Kobori, Koichi Inoue, Toshiya Kurotobi, Itsuro Morishima, Yumie Matsui, Hirosuke Yamaji, Yuko Nakazawa, Kengo Kusano, Yukiko Shimizu, Koji Hanazawa, Toshihiro Tamura, Chisato Izumi, Takeshi Morimoto, Koh Ono, Takeshi Kimura, Satoshi Shizuta, on behalf of the KPAF Investigators
Background: Catheter ablation (CA) for atrial fibrillation (AF) in patients on hemodialysis (HD) is reported to have a high risk of late recurrence (LR). However, the relationship between early recurrence (ER) within a 90-day blanking period after CA in AF patients and LR in HD patients remains unclear. Methods and Results: Of the 5,010 patients in the Kansai Plus Atrial Fibrillation Registry, 5,009
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Hypokalemia, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction Circ. J. (IF 3.3) Pub Date : 2023-12-25 Yoichiro Otaki, Tetsu Watanabe, Ryuhei Yamaguchi, Shingo Tachibana, Junya Sato, Shigehiko Kato, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Masafumi Watanabe
Background: Heart failure with preserved ejection fraction (HFpEF) is an increasing health problem associated with high morbidity and mortality rates. Several reports have shown an association between hypokalemia and clinical outcomes in patients with heart failure (HF). However, the association of hypokalemia with kidney function and clinical outcomes in patients with HFpEF remains unclear. Methods and Results:
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Developing Multidisciplinary Management of Heart Failure in the Super-Aging Society of Japan Circ. J. (IF 3.3) Pub Date : 2023-12-25 Yukihito Sato, Takashi Kuragaichi, Hiroyuki Nakayama, Kozo Hotta, Yuji Nishimoto, Takao Kato, Ryoji Taniguchi, Koichi Washida
The Japanese population is rapidly aging because of its long life expectancy and low birth rate; additionally, the number of patients with heart failure (HF) is increasing to the extent that HF is now considered a pandemic. According to a recent HF registry study, Japanese patients with HF have both medical and care-related problems. Although hospitalization is used to provide medical services, and
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Independent Link Between Use of Mineralocorticoid Receptor Antagonists and Muscle Wasting in Heart Failure Patients Not Receiving Renin-Angiotensin System Inhibitors Circ. J. (IF 3.3) Pub Date : 2023-12-25 Ryo Numazawa, Satoshi Katano, Toshiyuki Yano, Ryohei Nagaoka, Katsuhiko Ohori, Hidemichi Kouzu, Suguru Honma, Yusuke Fujisawa, Kotaro Yamano, Arata Osanami, Masayuki Koyama, Akiyoshi Hashimoto, Masato Furuhashi
Background: The renin-angiotensin system (RAS) activation is a proposed mechanism of muscle wasting (MW i.e., reduction in muscle mass). Although we reported that RAS inhibitors (RASIs) were associated with lower prevalence of MW in heart failure (HF) patients, the relationship between mineralocorticoid receptor (MR) signaling and MW has not been analyzed. Methods and Results: We analyzed data from
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Significance of End-Diastolic Forward Flow in Patients With Repaired Tetralogy of Fallot ― Its Interaction With the Left Ventricular Property and End Organ Damage ― Circ. J. (IF 3.3) Pub Date : 2023-12-25 Takuya Takahashi, Hirofumi Saiki, Akira Sato, Seiko Kuwata, Satoshi Nakano, Yumi Sato, Manami Akasaka, Junichi Koizumi, Hideaki Senzaki, Kotaro Oyama
Background: Although right ventricular (RV) enlargement may affect RV diastolic dysfunction assessed by end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (TOF), EDFF may also be modified by left ventricular (LV) hemodynamics. We hypothesized that EDFF is affected by LV hemodynamics, not limited to RV diastolic stiffening. Methods and Results: Among 145 consecutive patients
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Prognostic Comparison of Octogenarian vs. Non-Octogenarian With Acute Decompensated Heart Failure ― AURORA Study ― Circ. J. (IF 3.3) Pub Date : 2023-12-25 Masami Nishino, Yasuyuki Egami, Shodai Kawanami, Masaru Abe, Mizuki Ohsuga, Hiroaki Nohara, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Masamichi Yano
Background: Acute decompensated heart failure (ADHF) is the main cause of hospitalization and death of octogenarians, but no data on the 1-year post-discharge mortality rate. We evaluated the clinical status and predictors of 1-year mortality in octogenarians with ADHF. Methods and Results: From the AURORA (Acute Heart Failure Registry in Osaka Rosai Hospital) study, we examined 1,246 hospitalized
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Deep Learning Models for Predicting Left Heart Abnormalities From Single-Lead Electrocardiogram for the Development of Wearable Devices Circ. J. (IF 3.3) Pub Date : 2023-12-25 Masataka Sato, Satoshi Kodera, Naoto Setoguchi, Kengo Tanabe, Shunichi Kushida, Junji Kanda, Mike Saji, Mamoru Nanasato, Hisataka Maki, Hideo Fujita, Nahoko Kato, Hiroyuki Watanabe, Minami Suzuki, Masao Takahashi, Naoko Sawada, Masao Yamasaki, Shinnosuke Sawano, Susumu Katsushika, Hiroki Shinohara, Norifumi Takeda, Katsuhito Fujiu, Masao Daimon, Hiroshi Akazawa, Hiroyuki Morita, Issei Komuro
Background: Left heart abnormalities are risk factors for heart failure. However, echocardiography is not always available. Electrocardiograms (ECGs), which are now available from wearable devices, have the potential to detect these abnormalities. Nevertheless, whether a model can detect left heart abnormalities from single Lead I ECG data remains unclear. Methods and Results: We developed Lead I ECG