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Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial BioMed Res. Int. (IF 3.246) Pub Date : 2024-3-13 Hadir F. Eldessouky, Magda Marie
Background. Menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (AST) and osteocalcin in gingival crevicular fluid (GCF). The study is aimed at evaluating the effectiveness of regular inoculation of polyunsaturated
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Alleviating Neonatal Intensive Care Unit Stress: A Chinese Medicine Approach in Neonatal Rats BioMed Res. Int. (IF 3.246) Pub Date : 2024-3-2 Yingxin Li, Xi Huang, Yanlin Hu, Liming Yang, Xiujuan Zhang, Qiong Chen
Background. Premature infants are exposed to numerous stressors in neonatal intensive care unit (NICU) during a crucial period for brain development; this period exerts long-term influences on cognitive and behavioral development. Aims. To evaluate the effect of NICU-related stress on neonatal rat pups and explore the effect of Chinese medicine treatment (CMT). Methods. Sixty male rat pups were randomly
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Deep Learning Combined with Radiologist’s Intervention Achieves Accurate Segmentation of Hepatocellular Carcinoma in Dual-Phase Magnetic Resonance Images BioMed Res. Int. (IF 3.246) Pub Date : 2024-3-1 Yufeng Ye, Naiwen Zhang, Dasheng Wu, Bingsheng Huang, Xun Cai, Xiaolei Ruan, Liangliang Chen, Kun Huang, Zi-Ping Li, Po-Man Wu, Jinzhao Jiang, Guo Dan, Zhenpeng Peng
Purpose. Segmentation of hepatocellular carcinoma (HCC) is crucial; however, manual segmentation is subjective and time-consuming. Accurate and automatic lesion contouring for HCC is desirable in clinical practice. In response to this need, our study introduced a segmentation approach for HCC combining deep convolutional neural networks (DCNNs) and radiologist intervention in magnetic resonance imaging
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Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-29 Hamed Memariani, Mojtaba Memariani, Abdolmajid Ghasemian
Despite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan
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Screening Marine Microbial Metabolites as Promising Inhibitors of Borrelia garinii: A Structural Docking Approach towards Developing Novel Lyme Disease Treatment BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-29 Zarrin Basharat, Sadia Sattar, Ammar Abdulraheem Bahauddin, Abdulaziz K. Al Mouslem, Ghallab Alotaibi
Lyme disease caused by the Borrelia species is a growing health concern in many parts of the world. Current treatments for the disease may have side effects, and there is also a need for new therapies that can selectively target the bacteria. Pathogens responsible for Lyme disease include B. burgdorferi, B. afzelii, and B. garinii. In this study, we employed structural docking-based screening to identify
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Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F-Fluoromisonidazole and 18F-Fluorodeoxyglucose Positron Emission Tomography BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-28 Michinari Okamoto, Shigeru Yamaguchi, Ryosuke Sawaya, Sumire Echizenya, Yukitomo Ishi, Sadahiro Kaneko, Hiroaki Motegi, Takuya Toyonaga, Kenji Hirata, Miki Fujimura
Purpose. Glioblastoma is the most aggressive primary brain tumor, characterized by its distinctive intratumoral hypoxia. Sequential preoperative examinations using fluorine-18-fluoromisonidazole (18F-FMISO) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) could depict the degree of glucose metabolism with hypoxic condition. However, molecular mechanism of glucose metabolism
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Assessment of Violence during COVID-19 among Reproductive Age Women in Arsi Zone, South East Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-27 Gebi Agero, Kelil Haji Bedane, Mesfin Tafa Segni, Abdene Weya Kaso, Aman Nebi Ayato, Dida Batu Bedada, Akalu Ermias Mieso
Background. Preventive measures, like staying at home during lockdown, are mandatory during the COVID-19 pandemic. Particularly as a result of staying at home, violence against women is beginning to increase in correlation with these measures. Therefore, the purpose of this study was to assess the prevalence of violence against women of reproductive age during the COVID-19 pandemic in the Arsi Zone
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Anatomical Bases of the Temporal Muscle Trigger Points BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-24 Luis Carlos Fernandez Garrido, Giulianna Simonetti, Samir Omar Saleh, Flávio Hojaij, Mauro Andrade, Alfredo Luiz Jacomo, Flavia Emi Akamatsu
Background and Purpose. Myofascial pain syndrome (MPS) is a chronic or acute form of musculoskeletal pain that affects nearly three-quarters of the world’s population. It is characterized by muscle pain and stiffness, with palpable nodules and hyperirritability areas called myofascial trigger points (MTPs). The temporal muscle is frequently involved in MPS, and four MTPs in the temporal muscle have
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Analysis of Characteristics of Endometrial Carcinoma in Peri- and Postmenopausal Women with Abnormal Uterine Bleeding BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-24 Ye Yanli, Wang Tian Mei, Li Cong
Objective. To analyze the menstrual characteristics of endometrial carcinoma and investigate whether abnormal uterine bleeding in the perimenopausal period differs from postmenopausal bleeding. Methods. We conducted a retrospective analysis of 928 cases of endometrial carcinoma in patients admitted from January 2016 to December 2022. We gathered fundamental clinical data and analyzed distinct clinical
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The Oxidative Status and Na+/K+-ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-23 Amir Hossein Mohammadi, Ebrahim Balandeh, Jila Hasani, Mohammad Karimian, Vajiheh Arabshahi, Morteza Pourfarzam, Fereshteh Bahmani, Gholamreza Namazi
Background. Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including malondialdehyde (MDA) levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant
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A Systematic Review of Oral Modifications Caused by the Prolonged Application of Continuous Positive Airway Pressure (CPAP) and Intraoral Appliances in Patients with Obstructive Sleep Apnea (OSA) BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-23 Niloofar Jafarimehrabady, Andrea Scribante, Patrizia Defabianis, Giuseppe Merlati, Marina Consuelo Vitale
Objective. Prolonged use of oral devices as a substitute for traditional treatments has been studied in relation to the dental and skeletal changes associated with obstructive sleep apnea syndrome (OSA), which is a sleep-breathing disorder. Materials and Methods. A review of articles indexed in PubMed, Google Scholar, Cochrane Library, Scopus, Web of Sciences, and CINHAL databases in September 2022
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Exploring Lead-Like Molecules of Traditional Chinese Medicine for Treatment Quest against Aliarcobacter butzleri: In Silico Toxicity Assessment, Dynamics Simulation, and Pharmacokinetic Profiling BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-22 Zarrin Basharat, Ibrar Ahmed, Sulaiman Mohammed Alnasser, Alotaibi Meshal, Yasir Waheed
Background. Aliarcobacter butzleri is a Gram-negative, curved or spiral-shaped, microaerophilic bacterium and causes human infections, specifically diarrhea, fever, and sepsis. The research objective of this study was to employ computer-aided drug design techniques to identify potential natural product inhibitors of a vital enzyme in this bacterium. The pyrimidine biosynthesis pathway in its core genome
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Knowledge, Attitude, Practice, and Associated Factors of Implant Use in Women, Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-22 Kaleab Tesfaye Tegegne, Girma Teferi, Tadele Kassahun Wudu, Yideg Abinew, Eleni Tesfaye Tegegne, Mekibib Kassa Tessema
Background. The world is in a dramatic expansion of population that resulted from the continued high birth rates in developing countries. At present, only a handful of countries have reduced fertility rates. That is enough to make gains as a result of reduced fertility or to ensure that their population will stabilize unforeseeable future. Ethiopia is the second largest country by population in Africa
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Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-19 Mohammad Vahabirad, Sajedeh Daei, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi
Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal breast cells was assessed under the effects of different
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Patient Satisfaction with the Implementation of Telehealth in Ambulatory Care during the COVID-19 Pandemic: A Single Institution Experience BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-16 Berhane Yohannes Hailu, Ephrem Berhe, Awol Yemane, Merhawit Atsbha Abera, Samuel Berhane, Fikaden Berhe, Saba Abraham Belay, Abraha Gebreegziabher Hailu, Bereket Berhe Abreha, Hailemariam Gebrearegay Haileeyesus, Kidu Gidey
Background. COVID-19 has reduced the capacity for delivering essential health services due to lockdown restrictions. Telehealth is an effective alternative option to improve healthcare access. However, there remain implementation challenges to patient adoption in resource-limited settings such as Ethiopia. Therefore, the purpose of this study was to assess patient satisfaction following the implementation
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N-Substituted Phenylhydrazones Kill the Ring Stage of Plasmodium falciparum BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-13 Cedric Dzidzor Kodjo Amengor, Prince Danan Biniyam, Abena Amponsaa Brobbey, Francis Klenam Kekessie, Felix Kwame Zoiku, Sherif Hamidu, Patrick Gyan, Billy Mawunyo Abudey
Antimalarial resistance has hampered the effective treatment of malaria, a parasitic disease caused by Plasmodium species. As part of our campaign on phenotypic screening of phenylhydrazones, a library of six phenylhydrazones was reconstructed and evaluated for their in vitro antimalarial and in silico receptor binding and pharmacokinetic properties. The structures of the phenylhydrazone hybrids were
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Two Main Cancer Biomarkers as Molecular Targets of Binase Antitumor Activity BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-12 Elena Dudkina, Vera Ulyanova, Violetta Asmandiyarova, Valentina Vershinina, Olga Ilinskaya
Cancer is frequently coupled with the disturbance of key signaling pathways. Aberrant activation of the mitogen-activated protein kinase (MAPK) signaling cascade, occurring in over 85% of cancers, is mainly caused by the genetic alterations of its main components—oncogenes EGFR and RAS, and plays a crucial role in cell fate. The importance of EGFR and RAS proteins in a variety of tumors suggests that
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Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation BioMed Res. Int. (IF 3.246) Pub Date : 2024-2-5 Mariel Manzor, Sophia Koutsogiannaki, Marco DiBlasi, Matthew Schaefers, Gregory Priebe, Koichi Yuki
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that controls chloride current. A number of different CFTR transgenic mouse lines have been developed and subjected to both acute and chronic infection models. However, prior studies showed no substantial differences in bacterial clearance between CF and non-CF mice after
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Pharmacological Manipulation of Corticotropin-Releasing Factor Receptors in the Anterior and Posterior Subregions of the Insular Cortex Differently Affects Anxiety-Like Behaviors in the Elevated Plus Maze in Rats BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-31 Lucas M. Lopes, Lilian L. Reis-Silva, Bruno Rodrigues, Carlos C. Crestani
Neuroimaging data in humans and neurobiological studies in rodents have suggested an involvement of the insular cortex (IC) in anxiety manifestations. However, the local neurochemical mechanisms involved are still poorly understood. Corticotropin-releasing factor (CRF) neurotransmission has been described as a prominent neurochemical mechanism involved in the expression of anxiety-like behaviors, but
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Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-30 Zeynab Bayat, Tina Mazaheri, Homa Farhadifard, Amir Taherkhani
Objective. Oral squamous cell carcinoma (OSCC) is the most frequent oral cancer, constituting more than 90% of all oral carcinomas. The 5-year survival rate of OSCC patients is not satisfactory, and therefore, there is an urgent need for new practical therapeutic approaches besides the current therapies to overcome OSCC. Scutellaria baicalensis Georgi (SBG) is a plant of the family Lamiaceae with several
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Spectrum of Beta-Thalassemia Mutations in Potential Carriers with Microcytic Hypochromic Anemia from Mazandaran and Golestan, Northern Provinces of Iran BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-30 Seyed Saeed Mousavi, Hossein Karami, Ahmad Tamadoni, Hassan Mahmoudi, Ramin Shekarriz, Rita Siami, Mohammad Bagher Hashemi-Soteh
Introduction. β-Thalassaemia is the most common genetic disorder and is considered as a major public health concern in Iran. Different countrywide studies have shown a heterogeneous mutational basis of β-thalassaemia with different frequencies in each area. This study is aimed at investigating the common and rare mutations in Mazandaran and Golestan, northern provinces of Iran. Methods. 5425 microcytic
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Antiarthritic and Antioxidant Activities of Antrocaryon micraster Seed Extract and Its Fractions BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-27 Emmanuel Kofi Kumatia, Prince Kyei Baffour, Peter Bolah
Rheumatoid arthritis (RA) is an incurable debilitating disease which attacks the joints and impairs quality of life. Antrocaryon micraster is used to treat RA in African traditional medicine. However, its antiarthritic activity has not been pharmacologically studied. This study, therefore, reports the antiarthritic and antioxidant activities of A. micraster seed extract and its fractions. The seed
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Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-25 Kentaro Kawakami, Takao Fukuda, Masaaki Toyoda, Yuki Nakao, Chikako Hayashi, Yukari Watanabe, Tsukasa Aoki, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Miyu Shida, Terukazu Sanui, Takeshi Uchiumi, Fusanori Nishimura
Aim. The present study evaluated the therapeutic effects of luteolin in alleviating pulpitis of dental pulp- (DP-) derived microvesicles (MVs) via the inhibition of protein kinase R- (PKR-) mediated inflammation. Methodology. Proteomic analysis of immortalized human dental pulp (DP-1) cell-derived MVs was performed to identify PKR-associated molecules. The effect of luteolin on PKR phosphorylation
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Optimization of Growth Conditions for Chlorpyrifos-Degrading Bacteria in Farm Soils in Nakuru County, Kenya BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-25 Miriam Wepukhulu, Peter Wachira, Nderitu Huria, Paul Sifuna, Suliman Essuman, Micah Asamba
Chlorpyrifos (CP) is a chlorinated organophosphate pesticide. In Kenya, it is commonly used as an acaricide, particularly in dairy farming, leading to soil and water contamination. The study is aimed at isolating bacteria with CP-degrading potential and optimizing their growth conditions, including temperature, pH, and CP concentration. The enrichment culture technique was used, with minimal salt medium
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Knowledge, Attitude, and Practices on Food Safety among Food Handlers Working in Public Food Service Establishments in Lemi Kura Subcity, Addis Ababa, Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-23 Yordanos Fekadu, Mebrie Zemene Kinde, Gashaw Getaneh Dagnaw, Bereket Dessalegn, Haileyesus Dejene, Abebe Tesfaye Gessese
Foodborne diseases, resulting from poor food handling and sanitation practices, are common public health problems globally. The primary contributing factors to potential foodborne disease outbreaks are often attributed to the poor perception and practices of food handlers regarding food safety. This study is aimed at assessing the knowledge, attitude, and practices of food handlers working in public
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In Silico Identification and Characterization of Drug Targets in Streptococcus pneumoniae ATCC 700669 (Serotype 23F) by Subtractive Genomics BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-20 Tolossa Duguma, Hunduma Dinka
Streptococcus pneumoniae (S. pneumoniae) is an important pathogen worldwide that causes pneumococcal infections which are related to high rates of morbidity and mortality especially in young children, older adults, and immune-compromised persons. Antibiotic resistance in S. pneumoniae is a serious problem across the world from time to time, resulting in treatment failure and diminished value of older
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The “Weekday Effect”: A Decrease in Occupational Accidents from Monday to Friday—An Extension of the “Monday Effect” BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-13 Ignacio Fontaneda, Miguel A. Camino López, Oscar J. González Alcántara, Birgit A. Greiner
Objective. Study the variation in the number of accidents across days of the workweek, from Monday to Friday. Data and Method. All occupational accidents of full-time workers in Spain from 2011 to 2018 are analyzed. A total amount of 2,873,872 accidents are representative and not heavily affected by underreporting bias. Chi-squared test () and -value determine statistically significant differences
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The COVID-19 Severity and Its Association with Intestinal Parasite Coinfection and Urine Biochemical Parameters among COVID-19-Confirmed Patients Admitted to Debre Markos University COVID-19 Center, Northwest Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-13 Milkiyas Toru, Aytenew Atnaf, Hylemariam Mihiretie Mengist, Alemayehu Reta
Background. Though most people with COVID-19 disease show asymptomatic to mild illness, a substantial number of patients are at high risk of developing severe disease and adverse outcomes with long COVID-19 and death. Even though some studies showed that previously existing infections with parasites amend the host’s body defenses to increase resistance to infection with SARS-CoV-2, there is limited
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Identification of Genetic Variants for Diabetic Retinopathy Risk Applying Exome Sequencing in Extreme Phenotypes BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-13 Juan C. Zenteno, Oscar F. Chacón-Camacho, Vianey Ordoñez-Labastida, Antonio Miranda-Duarte, Camila Del Castillo, Jessica Nava, Fatima Mendoza, Luis Montes-Almanza, Germán Mora-Roldán, Karlen Gazarian
Background. Diabetic retinopathy (DR) risk has been shown to vary depending on ethnic backgrounds, and thus, it is worthy that underrepresented populations are analyzed for the potential identification of DR-associated genetic variants. We conducted a case-control study for the identification of DR-risk variants in Mexican population. Methods. We ascertained 60 type 2 diabetes mellitus (T2DM) patients
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Development and Validation of a Resilience Skills Questionnaire for Health Sector Professionals Based on Social Cognitive Theory BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-6 Maryam Akbari, Hamidreza Mokarami, Rosanna Cousins, Changiz Rahimi Taghanaki, Mohammad Hossein Kaveh, Mehdi Jahangiri
Good resilience skills support effective and timely adjustment to demanding situations in the workplace. Existing tools are insufficient to develop and evaluate workplace interventions to improve employee’s resilience skills. The aim of this study was to develop and validate a Resilience Skills Questionnaire (RSQ) using the key constructs of social cognitive theory—self-efficacy, self-regulation, and
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In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer’s Disease BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-6 Edward Jenner Tettevi, Deryl Nii Okantey Kuevi, Balagra Kasim Sumabe, David Larbi Simpong, Mahmoud B. Maina, Julius T. Dongdem, Mike Y. Osei-Atweneboana, Augustine Ocloo
Introduction. Alzheimer’s disease (AD) is a neurodegenerative disorder with no conclusive remedy. Yohimbine, found in Rauwolfia vomitoria, may reduce brain inflammation by targeting tumour necrosis factor-alpha (TNFα), implicated in AD pathogenesis. Metoserpate, a synthetic compound, may inhibit TNFα. The study is aimed at assessing the potential utility of repurposing metoserpate for TNFα inhibition
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Comparison of Embryological Results of Microinjection in Two Groups of Men with and without Requesting Sperm DNA Fragmentation Index Measurement BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-4 Naser AmirJannati, Arash Mohazzab, Manizheh Fathalian, Hamed Akhavizadegan
Introduction. The sperm DNA fragmentation index (DFI) is considered a valuable measure to assess male fertility, but the predictive value of DFI for the outcomes in assisted reproductive technology (ART) is still controversial. Therefore, this study is aimed at investigating the effect of requesting a DFI test or performing ART without DFI on the results observed in the embryology laboratory (number
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Citrus limon (L.) Osbeck Fruit Peel Extract Attenuates Carbon Tetrachloride-Induced Hepatocarcinogenesis in Sprague-Dawley Rats BioMed Res. Int. (IF 3.246) Pub Date : 2024-1-2 Alex Boye, Ernest Amponsah Asiamah, Orleans Martey, Frederick Ayertey
Background. Traditional herbal medicine practitioners in the Ashanti region of Ghana use the fruit peels of Citrus limon (L.) Osbeck (C. limon) in preventive and curative treatment of many cancers including liver cancer. This ethnobotanical claim remains to be verified scientifically. Aim of the Study. This study investigated prophylactic hepatoprotective and anti-HCC effects of C. limon peel extract
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Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-27 Afnan Abdulkareem Hussain, Ahmed Fadhel Al-Quisi, Ali A. Abdulkareem
Background. After tooth extraction, alveolar bone resorption is inevitable. This clinical phenomenon challenges dental surgeons aiming to restore esthetic and function. Alveolar ridge preservation can be applied to minimize dimensional changes with a new socket grafting material, an autogenous dentin graft, produced by mechanically and chemically processing natural teeth. This study assessed the safety
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Preparation of Synbiotic Yogurt Sauce Containing Spirulina platensis Microalgae Extract and Its Effect on the Viability of Lactobacillus acidophilus BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-26 Hamidreza Kazemeini, Asghar Azizian, Katayoun Ahmadi
Background. Preparing a healthy and practical substitute for mayonnaise and reducing the complications caused by its consumption are two of the concerns of the producers of this product. Therefore, this study was conducted with the aim of evaluating the possibility of producing synbiotic yogurt sauce prepared with Spirulina platensis microalgae extract (SPAE) as a valuable and alternative product for
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Factors Influencing Uptake of Prostate Cancer Screening among Men Aged 40 Years and Above in Kazo Town Council, Kazo District, Uganda: A Cross-Sectional Study BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-26 Smart Mwebembezi, Jon B. Alege, Florence Nakaggwa, Rose C. Nanyonga
Prostate cancer accounts for 20.3% of all cancers in men in sub-Saharan Africa. Early screening among at-risk groups is challenging in Uganda, with limited data on prostate cancer screening uptake in most districts, including newly established ones. The purpose of this study was to determine factors influencing the uptake of prostate cancer screening among men in Kazo Town Council, Kazo District, a
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Factor Analysis Related to the Change in Activities of Daily Living Performance of Stroke Patients BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-23 Hye Eun Kim, Ki Hun Cho
This study is aimed at investigating the factors influencing the change (improvement) in the performance of activities of daily living (ADL) in stroke patients. This study utilized data collected from 123 stroke patients at admission and discharge from a local rehabilitation hospital in South Korea between 2019 and 2022. We analyzed the correlations between ADL (Korean version of the Modified Barthel
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Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae) BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-22 Boly Rainatou, Belem-Kabré Wendkouni Leila M. Esther, Kaboré Boukaré, Compaoré Souleymane, Koala Moumouni, Ouédraogo Noufou
The present study investigated the phytochemical content of Hibiscus panduriformis, Alternanthera pungens, and Wissadula rostrata and assessed their radical scavenging and anti-inflammatory properties. n-Hexane, dichloromethane (DCM), ethyl acetate, and methanol extracts were prepared from the powdered plant parts. The phytochemical analysis was performed using qualitative high-performance thin-layer
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Using Appetitive Motivation to Train Mice for Spatial Learning in the Barnes Maze BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-19 Brigitta Tekla Tajti, Ojin Yoon, Aliz Judit Ernyey, Attila Gáspár, Bence Tamás Varga, István Gyertyán
The Barnes maze, a well-known spatial-learning paradigm, is based on the innate fear of rodents of large open spaces and their drive to hide. However, additional aversive stimuli (strong light and threatening sounds) are often necessary to provoke the hiding response while rendering the method cumbersome and more stressful. Our objective was to establish a Barnes maze-learning paradigm in mice using
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Formulation and Evaluation of Herbal-Based Antiacne Gel Preparations BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-18 Julia Afrakoma Ansong, Emmanuel Asante, Raphael Johnson, Mariam El Boakye-Gyasi, Noble Kuntworbe, Frederick William Akuffo Owusu, Kwabena Ofori-Kwakye
Acne vulgaris is an inflammatory skin condition that affects virtually everyone at some point. Papules, comedones, pustules, scarring, and nodules are standard features of the disease and can have a detrimental social and psychological impact on an individual. Although allopathic acne treatments are available, they have adverse side effects, are expensive, and are prone to cause antibiotic resistance
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Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-16 Jin Sil Choi, Ye Ji Ahn, SuHoon Lee, Dong Jun Park, JeongEun Park, Sun Mok Ha, Young Joon Seo
The Kir4.1 channel, an inwardly rectifying potassium ion (K+) channel, is located in the hair cells of the organ of Corti as well as the intermediate cells of the stria vascularis. The Kir4.1 channel has a crucial role in the generation of endolymphatic potential and maintenance of the resting membrane potential. However, the role and functions of the Kir4.1 channel in the progenitor remain undescribed
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Evidence-Based Practice and Its Associated Factors among Health Professionals Working at Public Hospitals in Southwest Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-13 Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Agmasie Damtew Walle, Addisalem Workie Demsash, Shimels Derso Kebede, Ayenew Sisay Gebeyehu, Sefefe Birhanu Tizie, Daniel Niguse Mamo, Sisay Yitayh Kassie
Introduction. “Evidence-based practice” (EBP) is the process of incorporating clinical expertise and taking patient values and preferences into consideration when making clinical decisions. It is used to describe the provision of high-quality patient care. Objective. This study is aimed at assessing evidence-based practice and associated factors among health professionals working at public hospitals
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Cone-Beam Computed Tomography Assessment of Prevalence of Procedural Errors in Maxillary Posterior Teeth BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-12 Ahmad Nouroloyouni, Yousef Nazi, Hesam Mikaieli Xiavi, Sara Noorolouny, Maryam Kuzekanani, Gianluca Plotino, James Laurence Walsh, Behzad Sheikhfaal, Rashin Alyali, Elham Tavakkol
A range of procedural errors can occur when performing endodontic treatment on posterior teeth. These errors may decrease the success rate in endodontic practice. This study assessed the prevalence of procedural errors and the quality of endodontic treatments in maxillary molars and premolars using cone-beam computed tomography (CBCT). CBCT scans from two private radiology centers were assessed retrospectively
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An Enhanced Technique of COVID-19 Detection and Classification Using Deep Convolutional Neural Network from Chest X-Ray and CT Images BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-11 Md Khairul Islam, Md Mahbubur Rahman, Md Shahin Ali, Md Sipon Miah, Md Habibur Rahman
Background. Coronavirus disease (COVID-19) is an infectious illness that spreads widely over a short period of time and finally causes a pandemic. Unfortunately, the lack of radiologists, improper COVID-19 diagnosing procedures, and insufficient medical supplies have all played roles in these devastating losses of life. Deep learning (DL) could be used to detect and classify COVID-19 for potential
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The Prevalence and Determinants of Inappropriate Oral Anticoagulant Use in Patients with Atrial Fibrillation, in Resource-Limited Setting BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-8 Abdella Birhan Yabeyu, Samiya Yassin Mohammed, Eshetu Shiferaw Legesse, Meaza Adugna, Zemene Demelash Kifle
Introduction. Anticoagulation treatment is routinely underused in patients with atrial fibrillation (AF), particularly in settings with limited resources. The current study is aimed at evaluating the appropriateness of oral anticoagulation treatment among AF patients at the Yekatit 12 Hospital Medical College (Y12HMC), Addis Ababa, Ethiopia. Methods. Institutional-based retrospective cross-sectional
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Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-7 Alaa R. Hameed, Sama Fakhri Ali, Sarah M. S. Alsallameh, Ziyad Tariq Muhseen, Nahlah Makki Almansour, Naif ALSuhaymi, Mahdi H. Alsugoor, Khaled S. Allemailem
Phosphatidylinositol 3,4,5-trisphosphate- (PIP3-) dependent Rac exchanger 1 (P-Rex1) functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity of Gβγ and PIP3 of the heterotrimeric G protein. P-Rex1 activates Rac GTPases for regulating cell invasion and migration and promotes metastasis in several human cancers including breast, prostate, and skin cancer. The protein
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Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-5 Zahra Rahimian, SeyedHassan Sadrian, Mina Shahisavandi, Hadi Aligholi, Mohammad M. Zarshenas, Alireza Abyar, Zahra Zeraatpisheh, Ali A. Asadi-Pooya
Peganum harmala L. and Lavandula angustifolia are two traditional herbs with probable antiseizure effects. This study evaluated the effects of these two herbal extracts on pentylenetetrazol- (PTZ-) induced seizures in mice. We prepared hydroalcoholic extracts using P. harmala seeds and the aerial parts of L. angustifolia and then randomly divided 190 mice into 19 groups. Normal saline (10 mg/kg), diazepam
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Radial Nerve Palsy Associated with Humeral Shaft Fractures in Children BioMed Res. Int. (IF 3.246) Pub Date : 2023-12-1 Wiktor Łukasz, Tomaszewski Ryszard, Damps Maria
Background. This is the first systematic review of the relationship between humeral shaft fractures and radial nerve palsy in children. The present comprehensive review is aimed at identifying important clinical findings between humeral diaphysis fractures and radial nerve injuries and assessing the effects of treatment. Methods. We searched electronic bibliographic databases, including PubMed, the
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Investigating the Effects of Intervention Strategies on Pneumonia and HIV/AIDS Coinfection Model BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-30 Shewafera Wondimagegnhu Teklu
HIV/AIDS and pneumonia coinfection have imposed a major socioeconomic and health burden throughout the world, especially in the developing countries. In this study, we propose a compartmental epidemic model on the spreading dynamics of HIV/AIDS and pneumonia coinfection to investigate the impacts of protection and treatment intervention mechanisms on the coinfection spreading in the community. In the
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Extent and Correlates of Self-Medication Practice among Community-Dwelling Adults in Eastern Ethiopia BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-30 Abdu Oumer, Ahmed Ale, Aragaw Hamza, Imam Dagne
Background. The use of medications without proper medical consultations poses significant health risks, drug resistance, and undiagnosed disease conditions, becoming a major pharmaceutical challenge in the 21st century. This study assessed the magnitude and associated factors of self-medication practice among adults in parts of Ethiopia. Methods. A community-based cross-sectional study was conducted
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Breast Cancer Screening: Knowledge, Attitudes, and Practices among Female University Students in The Gambia BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-30 Bakary Kinteh, Sambou L. S. Kinteh, Amienata Jammeh, Ebrima Touray, Amadou Barrow
Background. Breast cancer is the second most prevalent form of cancer in The Gambia, with an incidence rate of approximately 15% and a mortality rate exceeding 50% in 2020. The all-age prevalence stands at 11.25 per 100,000 population. In light of this, we conducted a study to assess the knowledge, attitude, and practice of breast cancer screening among female university students. Method. We conducted
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Unveiling the Potential of Bioinoculants and Nanoparticles in Sustainable Agriculture for Enhanced Plant Growth and Food Security BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-29 Arun Karnwal, Aradhana Dohroo, Tabarak Malik
The increasing public concern over the negative impacts of chemical fertilizers and pesticides on food security and sustainability has led to exploring innovative methods that offer both environmental and agricultural benefits. One such innovative approach is using plant-growth-promoting bioinoculants that involve bacteria, fungi, and algae. These living microorganisms are applied to soil, seeds, or
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Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-28 Toshihide Nishibata, Nobuaki Amino, Ruriko Tanaka-Kado, Susumu Tsujimoto, Tomoko Kawashima, Satoshi Konagai, Tomoyuki Suzuki, Masahiro Takeuchi
The tumor microenvironment (TME) is thought to influence the antitumor efficacy of immuno-oncology agents through various products of both tumor and stromal cells. One immune-suppressive factor is prostaglandin E2 (PGE2), a lipid mediator whose biosynthesis is regulated by ubiquitously expressed cyclooxygenase- (COX-) 1 and inducible COX-2. By activating its receptors, PGE2 induces immune suppression
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Presence of CRISPR CAS-Like Sequences as a Proposed Mechanism for Horizontal Genetic Exchanges between Trichomonas vaginalis and Its Associated Virus: A Comparative Genomic Analysis with the First Report of a Putative CRISPR CAS Structures in Eukaryotic Cells BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-27 Azra Kenarkoohi, Amir Abdoli, Arman Rostamzad, Mahmoud Rashnavadi, Razi Naserifar, Jahangir Abdi, Morteza Shams, Arezoo Bozorgomid, Sepideh Saeb, Dhurgham Al-Fahad, Kosar Khezri, Shahab Falahi
Introduction. Trichomonas vaginalis genome is among the largest genome size and coding capacities. Combinations of gene duplications, transposon, repeated sequences, and lateral gene transfers (LGTs) have contributed to the unexpected large genomic size and diversity. This study is aimed at investigating genomic exchange and seeking for presence of the CRISPR CAS system as one of the possible mechanisms
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Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-27 Sherif A. Abdelmottaleb Moussa, Samir W. Aziz, Noha A. Abd El-Latif, Samir A. E. Bashandy, Marawan A. Elbaset, Sherif M. Afifi, Tuba Esatbeyoglu, Sayed A. El Toumy, Josline Y. Salib
Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable
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Automated Detection of the Thoracic Ossification of the Posterior Longitudinal Ligament Using Deep Learning and Plain Radiographs BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-27 Sadayuki Ito, Hiroaki Nakashima, Naoki Segi, Jun Ouchida, Masahiro Oda, Ippei Yamauchi, Ryotaro Oishi, Yuichi Miyairi, Kensaku Mori, Shiro Imagama
Ossification of the ligaments progresses slowly in the initial stages, and most patients are unaware of the disease until obvious myelopathy symptoms appear. Consequently, treatment and clinical outcomes are not satisfactory. This study is aimed at developing an automated system for the detection of the thoracic ossification of the posterior longitudinal ligament (OPLL) using deep learning and plain
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Genome-Wide Identification and Characterization of Major RNAi Genes Highlighting Their Associated Factors in Cowpea (Vigna unguiculata (L.) Walp.) BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-24 Mohammad Nazmol Hasan, Md Parvez Mosharaf, Khandoker Saif Uddin, Keya Rani Das, Nasrin Sultana, Mst. Noorunnahar, Darun Naim, Md. Nurul Haque Mollah
In different regions of the world, cowpea (Vigna unguiculata (L.) Walp.) is an important vegetable and an excellent source of protein. It lessens the malnutrition of the underprivileged in developing nations and has some positive effects on health, such as a reduction in the prevalence of cancer and cardiovascular disease. However, occasionally, certain biotic and abiotic stresses caused a sharp fall
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Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-23 Y. Naeimzadeh, S. Ilbeigi, H. Dastsooz, M. Rafiee Monjezi, Y. Mansoori, S. M. B. Tabei
Invasive duct carcinoma (IDC) is one of the most common types of breast cancer (BC) in women worldwide, with a high risk of malignancy, metastasis, recurrence, and death. So far, molecular patterns among IDC cases have not been fully defined. However, extensive evidence has shown that dysregulated Rho family small GTPases (Rho GTPases) including Rho GTPase activating proteins (RhoGAPs) have important
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Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson’s Disease BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-20 Ekaterina I. Semenova, Suzanna A. Partevian, Marina V. Shulskaya, Margarita M. Rudenok, Maria V. Lukashevich, Nina M. Baranova, Olga B. Doronina, Kseniya S. Doronina, Anna V. Rosinskaya, Ekaterina Y. Fedotova, Sergey N. Illarioshkin, Petr A. Slominsky, Maria I. Shadrina, Anelya Kh. Alieva
Parkinson’s disease (PD) is a common chronic, age-related neurodegenerative disease. This disease is characterized by a long prodromal period. In this context, it is important to search for the genes and mechanisms that are involved in the development of the pathological process in the earliest stages of the disease. Published data suggest that blood cells, particularly lymphocytes, may be a model
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Hematological and Biochemical Laboratory Parameters in COVID-19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors BioMed Res. Int. (IF 3.246) Pub Date : 2023-11-18 Ghazaleh Alizad, Ali Asghar Ayatollahi, Armin Shariati Samani, Saeed Samadizadeh, Bahman Aghcheli, Abdolhalim Rajabi, Britt Nakstad, Alireza Tahamtan
Background. It is well known that laboratory markers could help in identifying risk factors of severe illness and predicting outcomes of diseases. Here, we performed a retrospective modeling study of severity and mortality predictors of hematological and biochemical laboratory parameters in Iranian COVID-19 patients. Methods. Data were obtained retrospectively from medical records of 564 confirmed