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Correction: antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023 Virol. J. (IF 4.8) Pub Date : 2024-03-18 Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad, Olav Hungnes
Correction: Fossum et al. Virology Journal (2024) 21:57 https://doi.org/10.1186/s12985-024-02326-w. Following the publication of the original article [1], the author reported that the figures had been mistakenly reordered during publication: Fig. 1 was presented as Fig. 4 Fig. 2 was presented as Fig. 5 Fig. 3 was presented as Fig. 1 Fig. 4 was presented as Fig. 2; and Fig. 5 was presented as Fig. 3
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Liver injury in COVID-19: an insight into pathobiology and roles of risk factors Virol. J. (IF 4.8) Pub Date : 2024-03-15 Abbas Tazarghi, Sahar Bazoq, Mohammad Hosein Taziki Balajelini, Mohsen Ebrahimi, Seyed Mehran Hosseini, Hadi Razavi Nikoo
COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage. Liver is susceptible to many viral pathogens, and due to its versatile functions in the body, it is of great interest to determine how hepatocytes may interact with SARS-CoV-2 in COVID-19 patients
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Development of a time-resolved fluorescence immunoassay kit for detecting canine coronavirus and parvovirus through double labeling Virol. J. (IF 4.8) Pub Date : 2024-03-11 Laiqing Li, Cuicui Chen, Huankun Liang, Wenqi Dong, V. N. Leontiev, Igor Vitalievich Voytov
Canine enteric coronavirus (CCV) and canine parvovirus type 2 (CPV-2) are the main pathogens responsible for acute gastroenteritis in dogs, and both single and mixed infections are common. This study aimed to establish a double-labeling time-resolved fluorescence immunoassay (TRFIA) to test and distinguish CCV and CPV-2 diseases. A sandwich double-labeling TRFIA method was established and optimized
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Congenital CMV infection in a Brazilian neonatal intensive care unit: high prevalence among twin newborns Virol. J. (IF 4.8) Pub Date : 2024-03-08 Lauro Juliano Marin, Pérola Rodrigues dos Santos, Felipe Charu Ramos, Uener Ribeiro dos Santos, Marcílio Marques, Luciana Debortoli de Carvalho, Sandra Rocha Gadelha, Victor Hugo Aquino
Cytomegalovirus (CMV) is one of the most important pathogens associated with congenital infection worldwide. Most congenital CMV-infected infants are asymptomatic at birth; however, some can develop delayed sequelae, especially hearing loss. This study aimed to investigate the prevalence of congenital CMV infection in a neonatal intensive care unit in a low-income region of Brazil. The objectives extended
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Seasonality of respiratory syncytial virus infection in children hospitalized with acute lower respiratory tract infections in Hunan, China, 2013–2022 Virol. J. (IF 4.8) Pub Date : 2024-03-07 Le-Yun Xie, Tao Wang, Tian Yu, Xian Hu, Le Yang, Li-Li Zhong, Bing Zhang, Sai-Zhen Zeng
In China, respiratory syncytial virus (RSV) infections traditionally occur during the spring and winter seasons. However, a shift in the seasonal trend was noted in 2020–2022, during the coronavirus disease 2019 (COVID-19) pandemic. This study investigated the seasonal characteristics of RSV infection in children hospitalized with acute lower respiratory tract infections (ALRTIs). The RSV epidemic
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SARS-CoV-2 infection increases airway bleeding risk in patients after tracheostomies Virol. J. (IF 4.8) Pub Date : 2024-03-07 Shupin Tang, Gongbiao Lin, Xiaobo Wu, Zhihong Chen
Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency of SARS-CoV-2 RNA test results in the upper and lower airway samples from patients after tracheostomies. Forty-four patients after temporary or permanent tracheostomy were divided into a positive
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RNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus Virol. J. (IF 4.8) Pub Date : 2024-03-07 Yunyun Yang, Qiandong Zhang, Haiqing Cai, Yi Feng, Anlin Wen, Ying Yang, Ming Wen
Chlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects. It has been demonstrated that chlorogenic acid effectively prevents and treats Duck enteritis virus (DEV) infection. This study aims to further elucidate the mechanism by which chlorogenic acid prevents DEV infection. Duck embryo fibroblast (DEF) cells were pre-treated
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Epidemiology and diagnosis technologies of human metapneumovirus in China: a mini review Virol. J. (IF 4.8) Pub Date : 2024-03-07 Yuan Feng, Tao He, Bo Zhang, Haibin Yuan, Yinfei Zhou
Human metapneumovirus (HMPV) is a newly identified pathogen causing acute respiratory tract infections in young infants worldwide. Since the initial document of HMPV infection in China in 2003, Chinese scientists have made lots of efforts to prevent and control this disease, including developing diagnosis methods, vaccines and antiviral agents against HMPV, as well as conducting epidemiological investigations
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Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells Virol. J. (IF 4.8) Pub Date : 2024-03-06 Nozethu Mjokane, Eric O. Akintemi, Saheed Sabiu, Onele M. N. Gcilitshana, Jacobus Albertyn, Carolina H. Pohl, Olihile M. Sebolai
The novel coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Data from the COVID-19 clinical control case studies showed that this disease could also manifest in patients with underlying microbial infections such as aspergillosis. The current study aimed to determine if the Aspergillus (A.) fumigatus culture media
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Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023 Virol. J. (IF 4.8) Pub Date : 2024-03-06 Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad, Olav Hungnes
Non-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally. The absence of influenza has raised concerns of waning immunity, and potentially more severe influenza seasons after the pandemic. To evaluate immunity towards influenza post-COVID-19 pandemic we have assessed influenza A epidemics in Norway from October 2016 to
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Bacterial isolation and genome analysis of a novel Klebsiella quasipneumoniae phage in southwest China’s karst area Virol. J. (IF 4.8) Pub Date : 2024-03-06 Yanju Liu, Jinfeng Wang, Ruoyu Zhao, Xiaoping Liu, Yang Dong, Wenyu Shi, Hongchen Jiang, Xiangyu Guan
Southwest China is one of the largest karst regions in the world. Karst environment is relatively fragile and vulnerable to human activities. Due to the discharge of sewage and domestic garbage, the karst system may be polluted by pathogenic bacteria. The detection of bacterial distribution and identification of phage capable of infecting them is an important approach for environmental assessment and
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Unraveling the genetic variations underlying virulence disparities among SARS-CoV-2 strains across global regions: insights from Pakistan Virol. J. (IF 4.8) Pub Date : 2024-03-06 Momina Jabeen, Shifa Shoukat, Huma Shireen, Yiming Bao, Abbas Khan, Amir Ali Abbasi
Over the course of the COVID-19 pandemic, several SARS-CoV-2 variants have emerged that may exhibit different etiological effects such as enhanced transmissibility and infectivity. However, genetic variations that reduce virulence and deteriorate viral fitness have not yet been thoroughly investigated. The present study sought to evaluate the effects of viral genetic makeup on COVID-19 epidemiology
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The POU-HD TFs impede the replication efficiency of several human papillomavirus genomes Virol. J. (IF 4.8) Pub Date : 2024-03-05 Martin Kala, Sofiya Babok, Nika Mikhailava, Marko Piirsoo, Alla Piirsoo
Human papillomavirus (HPV) is a double-stranded DNA virus that infects cutaneous and mucosal epithelial cells. HPV replication initiates at the origin (ori), located within a noncoding region near the major early promoter. Only two viral proteins, E1 and E2, are essential for replication, with the host cell contributing other necessary factors. However, the role of host cell proteins in regulating
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Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus Virol. J. (IF 4.8) Pub Date : 2024-03-04 Hao Song, Xiaowei Gao, Jing Li, Xinying Dong, Yanhui Fu, Lina Shao, Jiaoer Zhang, Hua-Ji Qiu, Yuzi Luo
Atypical porcine pestivirus (APPV) is a newly discovered swine pestivirus, which can cause congenital tremor and high mortality in newborn piglets and subclinical infection in adult pigs, leading to significant impacts on the pig industry. Currently, there is no approved serological method to assess APPV infection status in pig farms. In this study, the envelope glycoprotein E2 of APPV was highly expressed
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Prevalence and genotype distribution of HPV infections among women in Chengdu,China Virol. J. (IF 4.8) Pub Date : 2024-03-01 Junying Zhang, Tianzhi Zha, Xuemei Wang, Weijun He
Human papilloma virus (HPV) infection among female is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate and the target population screening rate among females are low, and the aims of this study on the genotype distribution and prevalence of HPV infection were to provide more targeted strategies for the prevention and treatment of cervical cancer and HPV-related diseases
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Diversity of astroviruses in wild animals in Yunnan province, China Virol. J. (IF 4.8) Pub Date : 2024-02-27 Xingyu Huang, Junjie Hou, Xiang Le, Yutong Hou, Lingsi Yang, Qian Li, Binghui Wang, Xueshan Xia
Astroviruses (AstVs) are single-stranded RNA viruses that have been detected in a wide range of mammals and birds. They are associated with numerous interspecies transmissions and viral recombination events, posing a threat to human and animal health. We collected 1,333 samples from wild animals, including bats, rodents, wild boars, and birds, from various states and cities in the Yunnan Province,
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Molecular epidemiology and phylogenetic analysis of feline calicivirus in Kunshan, China Virol. J. (IF 4.8) Pub Date : 2024-02-27 Semin Kim, Yixi Cheng, Zhenkun Fang, Xinyue Liu, Qiu Zhongqi, Yu Weidong, Aysun Yilmaz, Huseyin Yilmaz, Sajid Umar
Feline calicivirus (FCV) is a highly contagious virus in cats, which typically causes respiratory tract and oral infections. Despite vaccination against FCV being a regular practice in China, new FCV cases still occur. Antigenic diversity of FCV hinders the effective control by vaccination. This is first report which aims to investigate the molecular epidemiology and molecular characteristics of FCV
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Identification and characterisation of Gamma-herpesviruses in zoo artiodactyla Virol. J. (IF 4.8) Pub Date : 2024-02-23 Laura Bianchessi, Edmund Flach, Giulia Monacchia, Mark Dagleish, Madeleine Maley, Lauretta Turin, Mara Silvia Rocchi
Viruses within the γ-herpesviruses subfamily include the causative agents of Malignant Catarrhal Fever (MCF) in several species of the order Artiodactyla. MCF is a usually fatal lymphoproliferative disease affecting non-adapted host species. In adapted host species these viruses become latent and recrudesce and transmit during times of stress or immunosuppression. The undetected presence of MCF-causing
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Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1 Virol. J. (IF 4.8) Pub Date : 2024-02-23 Neda Baghban, Safieh Momeni, Emad Behboudi, Hassan Dianat-Moghadam, Amirhossein Darabi, Hadiseh Shokouhi Targhi, Mohsen Keshavarz
The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown promising results in the use of Arabic gum for the green synthesis of nanoparticles with strong antiviral
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A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment Virol. J. (IF 4.8) Pub Date : 2024-02-23 Levanco Keegan Asia, Esmé Jansen Van Vuren, Zander Lindeque, Monray Edward Williams
HIV infection compromises both the peripheral and central immune systems due to its pathogenic and neuropathogenic features. The mechanisms driving HIV-1 pathogenesis and neuropathogenesis involve a series of events, including metabolic dysregulation. Furthermore, HIV-subtype-specific variations, particularly alterations in the amino acid sequences of key viral proteins, are known to influence the
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Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis Virol. J. (IF 4.8) Pub Date : 2024-02-23 Yaqi Wang, Huaiya Xie, Luo Wang, Junping Fan, Ying Zhang, Siqi Pan, Wangji Zhou, Qiaoling Chen, Xueqi Liu, Aohua Wu, Hong Zhang, Jinglan Wang, Xinlun Tian
Azvudine has been approved for the treatment of coronavirus disease 2019 (COVID-19) patients in China, and this meta-analysis aims to illustrate the safety of azvudine and its effectiveness in reducing mortality. PubMed, Embase, Web of science, Cochrane Library and the Epistemonikos COVID-19 Living Overview of Evidence database (L.OVE) were searched to aggregate currently published studies. Cochrane
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Cytomegalovirus infection during pregnancy: cross-sectional survey of knowledge and prevention practices of healthcare professionals in French-speaking Switzerland Virol. J. (IF 4.8) Pub Date : 2024-02-21 Pauline Sartori, David Baud, Begoña Martinez de Tejada, Alexandre Farin, Marie-Claude Rossier, Wawrzyniec Rieder, Sylvie Rouiller, Romaine Robyr, Gaston Grant, Béatrice Eggel, Adrien Bruno, Maeva Pretalli, Bertrand Gainon, Romina Capoccia-Brugger, Laetitia Ammon-Chansel, Clarisse De Courten, Nathalie Beurret-Lepori, Jonathan Baert, Yvan Vial, Léo Pomar
Lack of Cytomegalovirus (CMV) knowledge among healthcare professionals has been proven to be the main threat to pregnant women's awareness, preventing them from reducing the risk of infection. The aims of this study were to assess the knowledge and practices of French-speaking Swiss perinatal professionals in terms of CMV prevention, as well as the sociodemographic-professional factors that influence
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Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections Virol. J. (IF 4.8) Pub Date : 2024-02-16 Nedaa M. Ismael, Mohamed Azzam, Mohamed Abdelmoteleb, Ayman El-Shibiny
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E. coli accounts for 80–90% of urinary tract infections that can result in urosepsis and septic shock. Consequently, multidrug-resistant uropathogenic E. coli poses a considerable risk to the healthcare
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Correction: Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication Virol. J. (IF 4.8) Pub Date : 2024-02-15 Thanyaporn Dechtawewat, Pucharee Songprakhon, Thawornchai Limjindaporn, Chunya Puttikhunt, Watchara Kasinrerk, Sawanan Saitornuang, Pa-thai Yenchitsomanus, Sansanee Noisakran
Correction: Virology Journal (2015) 12:14 https://doi.org/10.1186/s12985-014-0219-7 Following publication of the original article [1], the authors informed us that the citation number 5., “Recent advances in DENV receptors, The Scientific World Journal, Volume 2013,” was excluded from the original article due to its retraction in 2013. Dechtawewat et al. Virology Journal (2015) 12:14. https://doi.org/10
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Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines Virol. J. (IF 4.8) Pub Date : 2024-02-15 Frances Edillo, Rhoniel Ryan Ymbong, Anthoddiemn Olin Navarro, Maureen Mathilde Cabahug, Kristilynn Saavedra
Aedes albopictus is the secondary vector for dengue virus (DENV) in the Philippines, and also harbors chikungunya (CHIKV) and Zika (ZIKV) viruses. This study aimed to determine the minimum infection rates (MIRs) of CHIKV, DENV serotypes, and ZIKV in Ae. albopictus collected from selected two-site categories by altitude (highland [H] and lowland [L] sites) in Cebu city, Philippines during the wet (WS)
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Recognizing the role of Epstein-Barr virus in gastric cancer: transcriptomic insights into malignancy modulation Virol. J. (IF 4.8) Pub Date : 2024-02-14 Tabassom Sedaghat Anbouhi, Hossein Sazegar, Ebrahim Rahimi
Studies show that Epstein-Barr virus (EBV) infection can play a role in malignancy and increase the risk of gastric cancer (GC). The objective of this research was to pinpoint genes whose expression may be influenced by EBV and play a role in the development of GC. Candidate genes potentially susceptible to expression modulation in the presence of EBV were identified through the analysis of GSE185627
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Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre Virol. J. (IF 4.8) Pub Date : 2024-02-10 Reile Janssen, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck, Sunita Janssenswillen, Bram Slechten, Jannes Bode, Elke Wollants, Kristel Van Laethem, Annabel Rector, Mandy Bloemen, Anke Sijmons, Nathalie de Schaetzen, Arnaud Capron, Kurt Van Baelen, Thierry Pascal, Céline Vermeiren, Fabrice Bureau, Jo Vandesompele, Pieter De Smet, Wouter Uten, Hugues Malonne, Pierre Kerkhofs, Jo De Cock,
Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre (NRC) for respiratory pathogens, to be the first Belgian laboratory to develop and implement laboratory developed diagnostic assays for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and later to assess the quality of commercial kits. To meet
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Prevalence and progression of pneumonia in immunocompetent adults with varicella Virol. J. (IF 4.8) Pub Date : 2024-02-09 Ran Cheng, Fei Lin, Zhonghua Deng, Jingjin Liang, Xiaoguang Li, Ming Lu, Lu Li
Pneumonia is the most common complication of varicella infections. Although previous studies have tended to focus mainly on immunocompromised patients, varicella pneumonia can also occur in healthy adults. Therefore, in this study, we aimed to assess the progression of varicella pneumonia in immunocompetent hosts. This retrospective study involved immunocompetent adult outpatients with varicella who
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Mechanisms and consequences of mRNA destabilization during viral infections Virol. J. (IF 4.8) Pub Date : 2024-02-06 Soraya I. Shehata, J. Monty Watkins, James M. Burke, Roy Parker
During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the virus uses “host shut-off” systems to better compete for cellular resources and to limit the induction of the host antiviral response. Viral mechanisms for host shut-off involve targeting translation
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Novel neutralizing SARS-CoV-2-specific mAbs offer detection of RBD linear epitopes Virol. J. (IF 4.8) Pub Date : 2024-02-06 Seyed Mostafa Mostafavi Zadeh, Ali Ahmad Bayat, Hosein Shahsavarani, Feridoun Karimi-Busheri, Jafar Kiani, Roya Ghods, Zahra Madjd
To stop the spread of the COVID-19 disease, it is crucial to create molecular tools to investigate and diagnose COVID-19. Current efforts focus on developing specific neutralizing monoclonal antibodies (NmAbs) elicited against the receptor-binding domain (RBD). In the present study, recombinant RBD (rRBD) protein was produced in E. coli, followed by immunizing mice with purified rRBD. ELISA was applied
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Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C Virol. J. (IF 4.8) Pub Date : 2024-01-31 N. V. E. J. Buchholtz, M. M. Nühn, T. C. M. de Jong, T. A. T. Stienstra, K. Reddy, T. Ndung’u, Z. M. Ndhlovu, K. Fisher, S. Palmer, A. M. J. Wensing, J. Symons, M. Nijhuis
HIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir dynamics during antiretroviral therapy. The Intact Proviral DNA Assay (IPDA) provides the unique opportunity to quantify the intact and defective reservoir. The current IPDA is optimized for HIV-1 subtype B, the dominant subtype in resource-rich settings. However, subtype
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ZNF148 inhibits HBV replication by downregulating RXRα transcription Virol. J. (IF 4.8) Pub Date : 2024-01-31 Xinyan Yao, Kexin Xu, Nana Tao, Shengtao Cheng, Huajian Chen, Dapeng Zhang, Minli Yang, Ming Tan, Haibo Yu, Peng Chen, Zongzhu Zhan, Siyi He, Ranran Li, Chunduo Wang, Daiqing Wu, Jihua Ren
Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved in regulating the HBV life cycle will contribute to the development of new antiviral strategies. Zinc finger
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A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection Virol. J. (IF 4.8) Pub Date : 2024-01-30 Amirsasan Gorgzadeh, Ahmad Nazari, Adnan Ali Ehsan Ismaeel, Diba Safarzadeh, Jawad A. K. Hassan, Saman Mohammadzadehsaliani, Hadis Kheradjoo, Pooneh Yasamineh, Saman Yasamineh
Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an essential role in healthy and diseased cells as messengers of short- and long-distance intercellular communication. However, since exosomes are released by every kind of cell and may be found in blood and other bodily fluids, they may one day serve as biomarkers
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Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3 Virol. J. (IF 4.8) Pub Date : 2024-01-29 Zhilei Zhao, Shuyi Han, Qingxun Zhang, Ye Wang, Kening Yue, Salbia Abbas, Hongxuan He
Influenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host antiviral proteins and elucidate their antiviral mechanisms for the development of potential treatments. As a part of human innate immunity, host restriction factors can inhibit the replication of viruses, among which SAM and HD domain containing deoxynucleoside
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Severe COVID-19 and chronic kidney disease: bidirectional mendelian randomization study Virol. J. (IF 4.8) Pub Date : 2024-01-29 Haishan Lin, Bangwei Cao
Traditional observational research has revealed an association between severe COVID-19 and chronic kidney disease (CKD). It is unclear whether there is a causative connection between them. Our goal was to determine whether genetically predicted CKD is associated with the risk of critical COVID-19. We aimed to investigate potential underlying genetic mechanisms that could explain this relationship,
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Correction: Molecular epidemiology and phylodynamic analysis of enterovirus 71 in Beijing, China, 2009–2019 Virol. J. (IF 4.8) Pub Date : 2024-01-25 Jie Li, Zhichao Liang, Da Huo, Yang Yang, Renqing Li, Lei Jia, Xiaoli Wang, Chun Huang, Quanyi Wang
Correction: Virology Journal (2023) 20:256 https://doi.org/10.1186/s12985-023-02028-9. Following publication of the original article [1], the authors informed us about the below errors: 1. Table 2 is repetitively shown. 2. X-axis and Y-axis are missing in Fig. 4. 3. The supplementary materials 1, 7, 8, 9, 10, 11 and 12 need to be updated. The original article has been corrected. Li, et al. Virol J
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Exosome-mediated regulation of inflammatory pathway during respiratory viral disease Virol. J. (IF 4.8) Pub Date : 2024-01-25 Hamidreza Gheitasi, Mohammad Sabbaghian, Ali Akbar Shekarchi, Amir Ali Mirmazhary, Vahdat Poortahmasebi
Viruses have developed many mechanisms by which they can stimulate or inhibit inflammation and cause various diseases, including viral respiratory diseases that kill many people every year. One of the mechanisms that viruses use to induce or inhibit inflammation is exosomes. Exosomes are small membrane nanovesicles (30–150 nm) released from cells that contain proteins, DNA, and coding and non-coding
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Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2 Virol. J. (IF 4.8) Pub Date : 2024-01-25 Annie V. Roy, Michael Chan, Logan Banadyga, Shihua He, Wenjun Zhu, Michel Chrétien, Majambu Mbikay
Several in silico studies have determined that quercetin, a plant flavonol, could bind with strong affinity and low free energy to SARS-CoV-2 proteins involved in viral entry and replication, suggesting it could block infection of human cells by the virus. In the present study, we examined the ex vivo ability of quercetin to inhibit of SARS-CoV-2 replication and explored the mechanisms of this inhibition
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Porcine epidemic diarrhea virus strain CH/HLJ/18 isolated in China: characterization and phylogenetic analysis Virol. J. (IF 4.8) Pub Date : 2024-01-24 Yuyao Guo, Ling Sui, Deming Kong, Dan Liu, Yueyi Gao, Yanping Jiang, Wen Cui, Jiaxuan Li, Yijing Li, Li Wang
Porcine epidemic diarrhea (PED) is an infectious disease of the digestive tract caused by the porcine epidemic diarrhea virus (PEDV), characterized by vomiting, severe diarrhea, and high mortality rates in piglets. In recent years, the distribution of this disease in China has remarkably increased, and its pathogenicity has also increased. PEDV has been identified as the main cause of viral diarrhea
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Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt Virol. J. (IF 4.8) Pub Date : 2024-01-23 Marwa H. Elnagdy, Alshimaa Magdy, Waleed Eldars, Mohamed Elgamal, Ahmed Hazem El-Nagdy, Omnia Salem, Mohamed Magdy Elmowafy, Omar Ahmed Elborsh, Abdelrahman Walid Elshafey, Muhammad Magdy Kesba, Ahmed Elsaeed Abdulgalil, Ali Sobh
Since the emergence of the COVID-19 infection in China, it has caused considerable morbidity, mortality, and economic burden. It causes the vast majority of clinical manifestations, ranging from mild or even no symptoms to severe respiratory failure. There are many risk factors for severe COVID-19, such as old age, male gender, and associated comorbidities. A major role for genetic factors may exist
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A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity Virol. J. (IF 4.8) Pub Date : 2024-01-23 Wipawee Nittayananta, Hatairat Lerdsamran, Nopporn Chutiwitoonchai, Aornrutai Promsong, Teerapol Srichana, Kesinee Netsomboon, Jarunee Prasertsopon, Jaruta Kerdto
Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza virus is still a major worldwide health concern. Plants are a good source of bioactive compounds to be used as preventive measures for both inhibiting the virus binding and enhancing mucosal innate immunity. Curcumin has been shown to possess antiviral activity and modulate innate immunity. Therefore, the purpose
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Interference of pseudorabies virus infection on functions of porcine granulosa cells via apoptosis modulated by MAPK signaling pathways Virol. J. (IF 4.8) Pub Date : 2024-01-23 Lingcong Deng, Wenpeng Min, Songyangnian Guo, Jiping Deng, Xiaosong Wu, Dewen Tong, Anwen Yuan, Qing Yang
Pseudorabies virus (PRV) is one of the major viral pathogens leading to reproductive disorders in swine. However, little is known about the effects of PRV infection on porcine reproductive system. Ovarian granulosa cells are somatic cells surrounding oocytes in ovary and required for folliculogenesis. The present study aimed to investigate the interference of PRV on functions of porcine ovarian granulosa
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Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily Virol. J. (IF 4.8) Pub Date : 2024-01-23 Qi-Feng Zhang, Yu-Ji Zhang, Sheng Wang, Yu Wei, Han Zhang, Feng Li, Yong-Quan Deng
The Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However, the impact of COVID-19 on sperm quality remains uncertain. This retrospective study aimed to investigate the short-term and relatively long-term effects of COVID-19 infection on sperm quality. A total of 85 males with fertility requirements, who underwent semen
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N6-methyladenosine modification positively regulate Japanese encephalitis virus replication Virol. J. (IF 4.8) Pub Date : 2024-01-19 Min Yao, Zhirong Cheng, Xueyun Li, Yuexiang Li, Wei Ye, Hui Zhang, He Liu, Liang Zhang, Yingfeng Lei, Fanglin Zhang, Xin Lv
N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate immunity. However, the role of m6A in regulating JEV replication has not been investigated. Here, we show that the JEV genome contains m6A modification upon infection of mouse neuroblast cells (neuro2a). JEV infection results in a decrease in the expression of
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Correlation analysis of hepatic steatosis and hepatitis B virus: a cross-sectional study Virol. J. (IF 4.8) Pub Date : 2024-01-19 Sitong Yi, Guanghui Ren, Ying Zhu, Qingwei Cong
The co-occurrence of chronic hepatitis B (CHB) and metabolic dysfunction-associated fatty liver disease (MAFLD) has drawn considerable attention due to its impact on disease outcomes. This study aimed to investigate the association between hepatic steatosis and hepatitis B virus (HBV) and analyzed the influence of hepatic steatosis on hepatitis B virology in patients with CHB. In this cross-sectional
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An unusual diarrheal outbreak in the community in Eastern Thailand caused by Norovirus GII.3[P25] Virol. J. (IF 4.8) Pub Date : 2024-01-19 Patpong Udompat, Krongkan Srimuang, Pawinee Doungngern, Nattakarn Thippamom, Sininat Petcharat, Khwankamon Rattanatumhi, Sirorat Khiewbanyang, Pantila Taweewigyakarn, Somkid Kripattanapong, Sasiprapa Ninwattana, Ananporn Supataragul, Spencer L. Sterling, Chonticha Klungthong, Khajohn Joonlasak, Wudtichai Manasatienkij, Thomas S. Cotrone, Stefan Fernandez, Supaporn Wacharapluesadee, Opass Putcharoen
Sentinel laboratory surveillance for diarrheal disease determined norovirus to be the most common cause of non-bacterial gastroenteritis in people during the COVID-19 pandemic in Thailand. An increase in patients presenting with diarrhea and vomiting in hospitals across Chanthaburi province between December 2021 and January 2022 led to the need for the identification of viral pathogens that may be
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A bibliometric analysis of m6A methylation in viral infection from 2000 to 2022 Virol. J. (IF 4.8) Pub Date : 2024-01-18 Xing Tao, Gang Wang, Wudi Wei, Jinming Su, Xiu Chen, Minjuan Shi, Yinlu Liao, Tongxue Qin, Yuting Wu, Beibei Lu, Hao Liang, Li Ye, Junjun Jiang
N6-methyladenosine (m6A) methylation has become an active research area in viral infection, while little bibliometric analysis has been performed. In this study, we aim to visualize hotspots and trends using bibliometric analysis to provide a comprehensive and objective overview of the current research dynamics in this field. The data related to m6A methylation in viral infection were obtained through
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Epidemiology and genotypes analysis of human papillomavirus infection in Beijing, China Virol. J. (IF 4.8) Pub Date : 2024-01-16 Jiao Wang, Haotian Li, Jieqiong Zhang, Hui Wang, Ying Li, Zhaohui Liu, Hongtu Liu
This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in the female population in Beijing, China, and identify the relationship between HPV genotypes and host factors. HPV testing was performed on women aged 15–89 (mean age 38.0 ± 10.9 years) from Beijing in 2020. High-risk HPV genotyping real-time polymerase chain reaction was used to determine HPV genotypes. The
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Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications Virol. J. (IF 4.8) Pub Date : 2024-01-12 Arash Letafati, Omid Salahi Ardekani, Mina Naderisemiromi, Mehdi Norouzi, Mohammadreza Shafiei, Soheil Nik, Sayed-Hamidreza Mozhgani
Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play a crucial role in the immune system, have become recognized as vital participants in protecting the body against viral infections. These remarkable innate immune cells possess the unique ability to directly recognize and eliminate infected cells, thereby
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Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma Virol. J. (IF 4.8) Pub Date : 2024-01-12 Meead Hadi, Omer Qutaiba B. Allela, Mansoureh Jabari, Asna Mahyazadeh Jasoor, Omid Naderloo, Saman Yasamineh, Omid Gholizadeh, Leila Kalantari
Primary liver cancer, which is scientifically referred to as hepatocellular carcinoma (HCC), is a significant concern in the field of global health. It has been demonstrated that conventional chemotherapy, chemo-hormonal therapy, and conformal radiotherapy are ineffective against HCC. New therapeutic approaches are thus urgently required. Identifying single or multiple mutations in genes associated
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The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults Virol. J. (IF 4.8) Pub Date : 2024-01-11 Ahmed Azzam, Heba Khaled, Neveen Refaey, Shorouk Mohsen, Ola Ali El-Emam, Nada Dawood, Hebatalla A. Ahmed, Omar A. Soliman, Sana Mostafa, Heba Ramadan, Maha Mosa, Amora Omar Ibrahim Elmowafy, Shimaa Mohamed Abdou Rizk, Ahmed Zaki, Mostafa Hussien, Ameer Ahmed, Ahmad Ashraf Ezzat, Fatma E. Hassan
Previous meta-analyses estimating the prevalence of the post-COVID-19 condition (PCC) were confounded by the lack of negative control groups. This may result in an overestimation of the prevalence of those experiencing PCC, as these symptoms are non-specific and common in the general population. In this study, we aimed to compare the burden of persistent symptoms among COVID-19 survivors relative to
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Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin–angiotensin–aldosterone system on COVID-19 disease Virol. J. (IF 4.8) Pub Date : 2024-01-10 Christian M. Zobel, Hartmut Kuhn, Maximilian Schreiner, Werner Wenzel, Jasper Wendtland, Cengiz Goekeri, Lorenz Scheit, Klaas Oltmanns, Dominic Rauschning, Marica Grossegesse, Natalie Hofmann, Hubert Wirtz, Sebastian Spethmann
The coronavirus disease 2019 (COVID-19) pandemic is driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which has led to an enormous burden on patient morbidity and mortality. The renin–angiotensin–aldosterone system (RAAS) plays a significant role in various pulmonary diseases. Since SARS-CoV-2 utilizes the angiotensin-converting enzyme (ACE)2 receptor to exert its virulence
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HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors Virol. J. (IF 4.8) Pub Date : 2024-01-10 Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell
The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe diseases including adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy-tropical spastic paraparesis. No HTLV-1-specific anti-retrovirals have
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A regional genomic surveillance program is implemented to monitor the occurrence and emergence of SARS-CoV-2 variants in Yubei District, China Virol. J. (IF 4.8) Pub Date : 2024-01-08 Fangyuan Liu, Peng Deng, Jiuhong He, Xiaofeng Chen, Xinyu Jiang, Qi Yan, Jing Xu, Sihan Hu, Jin Yan
In December 2022, Chongqing experienced a significant surge in coronavirus disease 2019 (COVID-19) epidemic after adjusting control measures in China. Given the widespread immunization of the population with the BA.5 variant, it is crucial to actively monitor severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant evolution in Chongqing's Yubei district. In this retrospective study based
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Characteristics of human papillomavirus prevalence and infection patterns among women aged 25–64 according to age groups and cytology results in Ordos City, China Virol. J. (IF 4.8) Pub Date : 2024-01-08 Sumeng Wang, Shujun Liu, Sensen Tan, Jian Yin, Yufei Li, Fanghui Zhao, Youlin Qiao
The assessment of human papillomavirus (HPV) genotype distribution in terms of age and cervical lesions could contribute to the adoption of more targeted preventive approaches to specific populations against cervical cancer. The current study was conducted in Ordos City, China, with the aim of analyzing the HPV genotypes prevalence and infection patterns within a hospital-based population. The analysis
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Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome Virol. J. (IF 4.8) Pub Date : 2024-01-08 Shan-Shan Zhang, Xin Yang, Wan-Xue Zhang, Yiguo Zhou, Ting-Ting Wei, Ning Cui, Juan Du, Wei Liu, Qing-Bin Lu
The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis. A case–control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients
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Production of recombinant HPV11/16 E6/E7-MBP-His6 fusion proteins and their potential to induce cytokine secretion by immune cells in peripheral blood Virol. J. (IF 4.8) Pub Date : 2024-01-05 Mei-nian Xu, Mei-zhen Zhong, Si-ning Feng, Yan-qin Xu, Xiao-ming Peng, Kang Zeng, Xiao-wen Huang
Human papillomavirus (HPV) infection poses a significant threat to public health worldwide. Targeting the function of HPV E6 and E7 proteins and activating the host immune response against these proteins represent promising therapeutic strategies for combating HPV-related diseases. Consequently, the efficient production of soluble, high-purity E6 and E7 proteins is crucial for function and host immune
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Prevalence of high and low risk HPV genotypes among vaccinated and non-vaccinated people in Tehran Virol. J. (IF 4.8) Pub Date : 2024-01-05 Amir Gholamzad, Niloofar Khakpour, Mehrdad Hashemi, Mehrdad Gholamzad
Human Papillomavirus (HPV) is a prevalent STI (Sexually Transmitted Infection) that is estimated almost all sexually active Patients at some stage of their life will be infected by the virus. Although most HPV infections resolve spontaneously, some can result in health complications, such as genital warts and several types of cancer. This study analyzed the variety of HPV genotypes in females and males
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Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report Virol. J. (IF 4.8) Pub Date : 2024-01-04 Sheridan J. C. Baker, Landry E. Nfonsam, Daniela Leto, Candy Rutherford, Marek Smieja, Andrew G. McArthur
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many effects of infection with this pathogen are still unknown, with both chronic and repeated COVID-19 infection producing novel pathologies. An immunocompromised patient presented with chronic COVID-19 infection. The patient had history of Hodgkin’s lymphoma, treated
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The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effect Virol. J. (IF 4.8) Pub Date : 2024-01-04 Bo-Kyoung Jung, Yong Hee An, Sung Hoon Jang, Jin-Ju Jang, Seonhee Kim, Joo Hee Jeon, Jinju Kim, Jason Jungsik Song, Hyun Jang
Oncolytic viruses are being studied and developed as novel cancer treatments. Using directed evolution technology, structural modification of the viral surface protein increases the specificity of the oncolytic virus for a particular cancer cell. Newcastle disease virus (NDV) does not show specificity for certain types of cancer cells during infection; therefore, it has low cancer cell specificity