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Compliance with infection prevention and control standard precautions and factors associated with noncompliance among healthcare workers working in public hospitals in Addis Ababa, Ethiopia Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-03-13 Feyissa Regassa Senbato, Deneke Wolde, Merga Belina, Kehabtimer Shiferaw Kotiso, Girmay Medhin, Wondwossen Amogne, Tadesse Eguale
Standard Precautions (SPs) are the minimal infection prevention and control (IPC) measures that apply to all patient care activities at all times, regardless of whether the patient has a suspected or proven disease, in any place where healthcare service is provided. These evidence-based practices protect healthcare workers (HCWs) from infection while preventing the spread of infectious agents among
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Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum β-lactamase-producing Enterobacterales by a contaminated duodenoscope Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-03-08 Cansu Cimen, Erik Bathoorn, Arjo J. Loeve, Monika Fliss, Matthijs S. Berends, Wouter B. Nagengast, Axel Hamprecht, Andreas Voss, Mariëtte Lokate
Contamination of duodenoscopes is a significant concern due to the transmission of multidrug-resistant organisms (MDROs) among patients who undergo endoscopic retrograde cholangiopancreatography (ERCP), resulting in outbreaks worldwide. In July 2020, it was determined that three different patients, all had undergone ERCP with the same duodenoscope, were infected. Two patients were infected with blaCTX-M-15
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Automated surveillance of non-ventilator-associated hospital-acquired pneumonia (nvHAP): a systematic literature review Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-03-06 Aline Wolfensberger, Alexandra U. Scherrer, Hugo Sax
Hospital-acquired pneumonia (HAP) and its specific subset, non-ventilator hospital-acquired pneumonia (nvHAP) are significant contributors to patient morbidity and mortality. Automated surveillance systems for these healthcare-associated infections have emerged as a potentially beneficial replacement for manual surveillance. This systematic review aims to synthesise the existing literature on the characteristics
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Resident-, prescriber-, and facility-level factors associated with antibiotic use in long-term care facilities: a systematic review of quantitative studies Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-03-06 Aurélie Bocquier, Berkehan Erkilic, Martin Babinet, Céline Pulcini, Nelly Agrinier
Antimicrobial stewardship programmes are needed in long-term care facilities (LTCFs) to tackle antimicrobial resistance. We aimed to identify factors associated with antibiotic use in LTCFs. Such information would be useful to guide antimicrobial stewardship programmes. We conducted a systematic review of studies retrieved from PubMed, Cochrane Library, Embase, APA PsycArticles, APA PsycINFO, APA PsycTherapy
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Emergence and clonal expansion of Aeromonas hydrophila ST1172 that simultaneously produces MOX-13 and OXA-724 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-03-03 Xinfei Chen, Minya Lu, Yao Wang, Han Zhang, Xinmiao Jia, Peiyao Jia, Wenhang Yang, Jiawei Chen, Guobin Song, Jianguo Zhang, Yingchun Xu
Aeromonas hydrophila infections can cause gastrointestinal symptoms such as diarrhea; however, deep infections are rarely reported. Outbreaks of A. hydrophila are reported more frequently in fish, poultry, and snakes than in humans. This study aimed to track clonal relatedness of deep infections caused by A. hydrophila using whole genome sequencing (WGS). We collected three isolates of A. hydrophila
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Comparison of disease and economic burden between MRSA infection and MRSA colonization in a university hospital: a retrospective data integration study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-29 Aki Hirabayashi, Koji Yahara, Keisuke Oka, Toshiki Kajihara, Teruko Ohkura, Yumiko Hosaka, Keigo Shibayama, Motoyuki Sugai, Tetsuya Yagi
Although there is a growing concern and policy regarding infections or colonization caused by resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), the prognosis of MRSA infections compared to that of methicillin-susceptible Staphylococcus aureus (MSSA) infections remains controversial. Moreover, there have not been any studies comparing both the burden of disease and its
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Updates and future directions regarding hand hygiene in the healthcare setting: insights from the 3rd ICPIC alcohol-based handrub (ABHR) task force Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-29 Ermira Tartari, Fernando Bellissimo-Rodrigues, Daniela Pires, Carolina Fankhauser, Nasim Lotfinejad, Hiroki Saito, Miranda Suchomel, Axel Kramer, Benedetta Allegranzi, John Boyce, Hugo Sax, Andrew J. Stewardson, Didier Pittet
Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) pose threats to global health. Effective hand hygiene is essential for preventing HAIs and the spread of AMR in healthcare. We aimed to highlight the recent progress and future directions in hand hygiene and alcohol-based handrub (ABHR) use in the healthcare setting. In September 2023, 42 experts in infection prevention and
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Systematic scoping review of automated systems for the surveillance of healthcare-associated bloodstream infections related to intravascular catheters Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-28 Nasim Lotfinejad, Jean-Marie Januel, Sarah Tschudin-Sutter, Peter W Schreiber, Bruno Grandbastien, Lauro Damonti, Elia Lo Priore, Alexandra Scherrer, Stephan Harbarth, Gaud Catho, Niccolò Buetti
Intravascular catheters are crucial devices in medical practice that increase the risk of healthcare-associated infections (HAIs), and related health-economic adverse outcomes. This scoping review aims to provide a comprehensive overview of published automated algorithms for surveillance of catheter-related bloodstream infections (CRBSI) and central line-associated bloodstream infections (CLABSI).
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Prevalence of colistin resistance in clinical isolates of Acinetobacter baumannii: a systematic review and meta-analysis Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-28 Narjess Bostanghadiri, Negar Narimisa, Maryam Mirshekar, Leila Dadgar-Zankbar, Elahe Taki, Tahereh Navidifar, Davood Darban-Sarokhalil
The development of colistin resistance in Acinetobacter baumannii during treatment has been identified in certain patients, often leading to prolonged or recurrent infections. As colistin, is the last line of therapy for A. baumannii infections that are resistant to almost all other antibiotics, colistin-resistant A. baumannii strains currently represent a significant public health threat, particularly
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The combined application of hand hygiene and non-sterile gloves by nurses in a tertiary hospital: a multi methods study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-28 Mireille Dekker, Rosa van Mansfeld, Marjon Borgert, Jolanda Maaskant, Frederique Paulus, Annamarike Seller, Irene P. Jongerden
The application of hand hygiene (HH) and the use of non-sterile gloves (NSG) in daily care is highly intertwined. We aimed (1) to assess the combined application of HH and NSG among nurses and (2) to explore determinants that influence their ability to combine both measures in their care. In a multi-methods study, we combined direct observations of care episodes with semi-structured interviews with
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The prevalence and clinical context of antimicrobial resistance amongst medical inpatients at a referral hospital in Rwanda: a cohort study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-22 Olivier Bizimungu, Peter Crook, Jean Félix Babane, Léopold Bitunguhari
Antimicrobial resistance (AMR) is a growing global concern. AMR surveillance is a crucial component of the international response; however, passive surveillance of laboratory data is limited without corresponding patient-level clinical data. This study sought to examine the burden of AMR amongst medical inpatients in Rwanda, in the context of their clinical presentations and prior antibiotic exposures
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Prevalence, regional distribution, and trends of antimicrobial resistance among female outpatients with urine Klebsiella spp. isolates: a multicenter evaluation in the United States between 2011 and 2019 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-14 Keith S. Kaye, Vikas Gupta, Aruni Mulgirigama, Ashish V. Joshi, Gang Ye, Nicole E. Scangarella-Oman, Kalvin Yu, Fanny S. Mitrani-Gold
Antimicrobial resistance research in uncomplicated urinary tract infection typically focuses on the main causative pathogen, Escherichia coli; however, little is known about the antimicrobial resistance burden of Klebsiella species, which can also cause uncomplicated urinary tract infections. This retrospective cohort study assessed the prevalence and geographic distribution of antimicrobial resistance
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Introduction and spread of vancomycin-resistant Enterococcus faecium (VREfm) at a German tertiary care medical center from 2004 until 2010: a retrospective whole-genome sequencing (WGS) study of the molecular epidemiology of VREfm Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-14 Aila Caplunik-Pratsch, Bärbel Kieninger, Veronika A. Donauer, Johanna M. Brauer, Vanessa M. K. Meier, Corinna Seisenberger, Anca Rath, Daniel Loibl, Anja Eichner, Jürgen Fritsch, Wulf Schneider-Brachert
In most of Europe and especially in Germany, there is currently a concerning rise in the number of hospital-acquired infections due to vancomycin-resistant Enterococcus faecium (VREfm). Therefore, there is a need to improve our understanding of the way VREfm spreads in hospitals. In this study, we investigated the molecular epidemiology of VREfm isolates from the first appearance at our university
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Closing the antimicrobial stewardship gap - a call for LMICs to embrace the global antimicrobial stewardship accreditation scheme Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-14 Bashar Haruna Gulumbe, Mohammed Bashar Danlami, Abdulrakib Abdulrahim
The escalating challenge of antimicrobial resistance (AMR) poses a considerable concern for global health, particularly impacting low- and middle-income countries (LMICs). This article highlights the critical importance of tackling AMR in LMICs by adopting the Global Antimicrobial Stewardship Accreditation Scheme (GAMSAS). GAMSAS is portrayed as a holistic and sustainable strategy for antimicrobial
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On the onset and dispersal of a major MDR TB clone among HIV-negative patients, Tunisia Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-14 Naira Dekhil, Helmi Mardassi
To carry out a whole genome sequencing (WGS)-based investigation on the emergence and spread of the largest multidrug-resistant tuberculosis (MDR TB) outbreak that has been thriving among HIV-negative patients, Tunisia, since the early 2000s. We performed phylogeographic analyses and molecular dating based on a WGS dataset representing 68 unique Mycobacterium tuberculosis isolates, covering almost
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Hip prosthesis and colon surgery, a decade of surveillance on surgical site infections in Italy, a prospective cohort study: rates, trends, and disease burden in DALYs Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-12 Valerio Bordino, Costanza Vicentini, Alessandro Roberto Cornio, Maria Michela Gianino, Carla Maria Zotti
Surveillance programs are a key element of interventions aiming to reduce rates of surgical site infections (SSIs). The aim of this study was to evaluate rates and trends of SSIs following hip arthroplasty and colon surgery procedures in Piedmont, a region in North-western Italy, from 2010 to 2019. Further, we aimed to assess the burden of SSIs in terms of Disability-Adjusted Life-Years (DALYs). A
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Challenges and success stories of the implementation of infection control and antimicrobial stewardship strategies: proceedings of the 5th Global Ministerial Summit on Patient Safety, 2023 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-08 Andrea C. Büchler, Murielle Haddad Galas, Niccolò Buetti, Emine Alp, Anucha Apisarnthanarak, Gerald Dziekan, Valeria Fabre, Simon Gottwalt, Kazuaki Jindai, Babacar Ndoye, Hilda Márquez Villareal, Fernando Otaiza, Didier Pittet, Natalie Schellack, Céline Gardiol, Stephan Harbarth
The 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February 2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less Harm, Better Care – from Resolution to Implementation”, focusing on the challenges of implementation of infection prevention and control (IPC) strategies as well as antimicrobial stewardship
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The accuracy of fully-automated algorithms for the surveillance of central venous catheter-related bloodstream infection in hospitalised patients Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-02-05 Moa Karmefors Idvall, Hideyuki Tanushi, Andreas Berge, Pontus Nauclér, Suzanne Desirée van der Werff
Continuous surveillance for healthcare-associated infections such as central venous catheter-related bloodstream infections (CVC-BSI) is crucial for prevention. However, traditional surveillance methods are resource-intensive and prone to bias. This study aimed to develop and validate fully-automated surveillance algorithms for CVC-BSI. Two algorithms were developed using electronic health record data
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Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021–2022 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-30 Viivi Heljanko, Olga Tyni, Venla Johansson, Jussa-Pekka Virtanen, Kati Räisänen, Kirsi-Maarit Lehto, Anssi Lipponen, Sami Oikarinen, Tarja Pitkänen, Annamari Heikinheimo
Antimicrobial resistance (AMR) is a critical threat to human health. Escherichia coli and Klebsiella pneumoniae are clinically the most important species associated with AMR and are the most common carbapenemase-producing (CP) Enterobacterales detected in human specimens in Finland. Wastewater surveillance has emerged as a potential approach for population-level surveillance of AMR, as wastewater could
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Perinatal colonization with extended-spectrum beta-lactamase-producing and carbapenem-resistant Gram-negative bacteria: a hospital-based cohort study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-29 Ashley Styczynski, Mohammed Badrul Amin, Kazi Injamamul Hoque, Shahana Parveen, Abu Faisal Md Pervez, Dilruba Zeba, Akhi Akhter, Helen Pitchik, Mohammad Aminul Islam, Muhammed Iqbal Hossain, Sumita Rani Saha, Emily S. Gurley, Stephen Luby
Antimicrobial resistance (AMR) is a growing global health threat that contributes to substantial neonatal mortality. Bangladesh has reported some of the highest rates of AMR among bacteria causing neonatal sepsis. As AMR colonization among newborns can predispose to infection with these bacteria, we aimed to characterize the frequency of and risk factors for colonization of mothers and newborns during
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Health system barriers to the implementation of the national action plan to combat antimicrobial resistance in Vietnam: a scoping review Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-25 Giang N. Pham, Tho T. H. Dang, Thu-Anh Nguyen, Shukry Zawahir, Hien T. T. Le, Joel Negin, Carmen Huckel Schneider, Greg J. Fox
Vietnam is among 11 countries in the Western Pacific region that has developed a National Action Plan for Antimicrobial Resistance (NAPCA). This scoping review characterises health system barriers to the implementation of the Vietnam NAPCA, with reference to the WHO Health Systems Framework. Over 7 years, between 2013 and 2020, the Ministry of Health (MOH) of Vietnam has been implementing activities
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Healthcare-associated infections and antimicrobial use in acute care hospitals in Greece, 2022; results of the third point prevalence survey Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-25 Konstantinos Palaiopanos, Dimitra Krystallaki, Kassiani Mellou, Petros Kotoulas, Christina-Anna Kavakioti, Styliani Vorre, Georgia Vertsioti, Maria Gkova, Antonios Maragkos, Kyriaki Tryfinopoulou, Dimitrios Paraskevis, Sotirios Tsiodras, Theoklis Zaoutis
The burden of healthcare-associated infections (HAIs) and the extent of antimicrobial use (AU) are periodically recorded through Point Prevalence Surveys (PPS) in acute care hospitals coordinated by the European Centre for Disease Prevention and Control (ECDC). In previous PPSs, Greece demonstrated increased HAI and AU prevalence: 9% and 54.7% in 2011–2012, and 10% and 55.6% in 2016–2017, respectively
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Incidence of catheter-associated urinary tract infections by Gram-negative bacilli and their ESBL and carbapenemase production in specialized hospitals of Bahir Dar, northwest Ethiopia Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-25 Zelalem Asmare, Tewachew Awoke, Chalachew Genet, Alemale Admas, Addisu Melese, Wondemagegn Mulu
Catheter-associated urinary tract infections (CAUTIs) due to multidrug-resistant Gram-negative bacilli (GNB) is a common concern globally. Investigating the incidence of CAUTI and associated antibiotic resistance has paramount importance from the health care associated infections perspective. This study therefore assessed the incidence of CAUTIs due to GNB and the production of extended-spectrum beta-lactamase
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Reported antibiotic use among patients in the multicenter ANDEMIA infectious diseases surveillance study in sub-saharan Africa Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-25 Imke Wieters, Siobhan Johnstone, Sheila Makiala-Mandanda, Armel Poda, Chantal Akoua-Koffi, Muna Abu Sin, Tim Eckmanns, Valentina Galeone, Firmin Nongodo Kaboré, François Kahwata, Fabian H. Leendertz, Benoit Mputu, Abdoul-Salam Ouedraogo, Nicola Page, Susanne B. Schink, Fidèle Sounan Touré, Adjaratou Traoré, Marietjie Venter, Ann Christin Vietor, Grit Schubert, Sara Tomczyk
Exposure to antibiotics has been shown to be one of the drivers of antimicrobial resistance (AMR) and is critical to address when planning and implementing strategies for combatting AMR. However, data on antibiotic use in sub-Saharan Africa are still limited. Using hospital-based surveillance data from the African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents
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Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-23 Md. Golam Dostogir Harun, Shariful Amin Sumon, Istiaque Hasan, Fairoze Masuda Akther, Md. Saiful Islam, Md. Mahabub Ul Anwar
Antimicrobial stewardship programs (ASPs) are pivotal components of the World Health Organization's Global Action Plan to combat antimicrobial resistance (AMR). ASPs advocate rational antibiotic usage to enhance patient-centered outcomes. However, existing evidence on ASPs and their determinants is largely limited to well-equipped hospitals in high-income nations. This scoping review aimed to examine
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Hand hygiene compliance in a Brazilian COVID-19 unit: the impact of moments and contact precautions Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-22 Marília Duarte Valim, Jéssica Regina Rossetto, Juliano Bortolini, Loreen Herwaldt
Healthcare-associated infections are among the most common complications during hospitalization. These infections increase morbidity and mortality and they increase length of hospital stay and the cost of healthcare. The aims of our study were to monitor hand hygiene (HH) compliance, HH technique quality and factors related to HH practice among health professionals in a COVID-19 Intensive Care Unit
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Knowledge, attitudes and practices towards community-acquired pneumonia and COVID-19 among general population: a cross-sectional study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-17 Er Hong, Jia Mao, Zhicheng Ke, Wei Tao
This study aimed to assess the knowledge, attitudes, and practices (KAP) of the general population to community-acquired pneumonia (CAP) and COVID-19. A cross-sectional study was conducted between September 2022 and February 2023, involving the general population from Ningbo Municipal Hospital of Traditional Chinese Medicine with a self-developed questionnaire. A total of 637 valid questionnaires were
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Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-17 Claire Durand, Karine Risso, Michael Loschi, Nicolas Retur, Audrey Emery, Johan Courjon, Thomas Cluzeau, Michel Carles
The 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile neutropenia in stable patients. To assess the efficacy of an antimicrobial stewardship (AMS) intervention promoting early de-escalation and discontinuation of EAT in high-risk neutropenic patients. This before-after study was conducted in the hematology department of the
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Implementation of the WHO core components of an infection prevention and control programme in two sub-saharan African acute health-care facilities: a mixed methods study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-15 R. Wood, W. Tembele, A. Hema, A. Somé, E. Kinganda-Lusamaki, C. Basilubo, R. Lumembe, N. Alama, G. Mbunsu, A. Zongo, S. Ahuka, J. J. Muyembe, F. Leendertz, T. Eckmanns, G. Schubert, T. Kagoné, S. Makiala, S. Tomczyk
The coronavirus pandemic again highlighted the need for robust health care facility infection prevention and control (IPC) programmes. WHO guidelines on the core components (CCs) of IPC programmes provides guidance for facilities, but their implementation can be difficult to achieve in resource-limited settings. We aimed to gather evidence on an initial WHO IPC implementation experience using a mixed
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On-site evaluation as external quality assessment of microbiology laboratories involved in sentinel laboratory-based antimicrobial resistance surveillance network in Burkina Faso Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-08 Emmanuel Zongo, Emilie Dama, Dame Yenyetou, Merci Muhigwa, Abdoulaye Nikiema, Georges Anicet Dahourou, Abdoul-Salam Ouedraogo
The laboratory-based surveillance of antimicrobial resistance (AMR) is a priority component of the multisectoral national action plan to combat AMR in Burkina Faso. This study aimed to assess the QMS of microbiology laboratories involved in the Sentinel laboratory-based antimicrobial resistance surveillance network in Burkina Faso. A cross-sectional study was conducted from September 1st to November
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Exploring factors for antibiotic over-prescription in children with acute upper respiratory tract infections in Assiut, Egypt: a qualitative study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-07 Mahmoud Attia AbdEl-Aty, Mariam Taher Amin, Sabra Mohamed Ahmed, Ghada Omar Elsedfy, Amira Fathy El-Gazzar
Over-prescription of antibiotics contributes to antibiotic resistance, which is a global health threat. Egypt has alarmingly high rates of antibiotic over-prescription for acute upper respiratory tract infections (URIs) in children. To effectively address this issue, it is important to understand the various factors that influence prescription behaviors. The Teixeira antibiotic prescription behavioral
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Investigating environmental transmission to resolve a Bacillus cereus group outbreak in a neonatal intensive care unit using core genome multilocus sequence typing Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2024-01-07 Hauke Tönnies, Axel Heep, Jörg Herrmann, Matthias Lange, Alexander Mellmann, Axel Hamprecht
We analyzed an outbreak of Bacillus cereus group (Bcg) at a single-center neonatal intensive care unit level IV by conducting comprehensive sampling of both patients and the environment. Between 06/2020 and 10/2021, all Bcg isolates identified by both regular colonization screening and additional sampling of the environment were subjected to whole-genome sequencing, followed by in vitro extraction
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Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-20 Sara Shbaita, Safaa Abatli, Mamoun W. Sweileh, Banan M Aiesh, Ali Sabateen, Husam T. Salameh, Adham AbuTaha, Sa’ed H. Zyoud
Pseudomonas infections are among the most common infections encountered in hospitalized patients, especially those with chronic illnesses or an immunocompromised state. Management of these infections has become challenging due to increased antibiotic resistance. Therefore, this study examines the antibiotic resistance profiles of Pseudomonas spp. and the associated factors among patients admitted to
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Dynamics of Staphylococcus aureus in patients and the hospital environment in a tertiary care hospital in the Netherlands Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-20 Adriënne S. van der Schoor, Anne F. Voor in ’t holt, Willemien H.A. Zandijk, Marco J. Bruno, Diederik Gommers, Johannes P.C. van den Akker, Johanna M. Hendriks, Juliëtte A. Severin, Corné H.W. Klaassen, Margreet C. Vos
The dynamics of Staphylococcus aureus in patients and the hospital environment are relatively unknown. We studied these dynamics in a tertiary care hospital in the Netherlands. Nasal samples were taken from adult patients at admission and discharge. Isolates cultured from clinical samples taken before and during hospitalization from these patients were included. Environmental samples of patient rooms
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Healthcare‑associated infections in intensive care unit patients with and without COVID-19: a single center prospective surveillance study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-18 Nando Bloch, Susanne Rüfenacht, Magdalena Ludwinek, Waldemar Frick, Gian-Reto Kleger, Florian Schneider, Werner C. Albrich, Domenica Flury, Stefan P Kuster, Matthias Schlegel, Philipp Kohler
The coronavirus disease 2019 (COVID-19) pandemic led to a global increase in healthcare-associated infections (HAI) among intensive care unit (ICU) patients. Whether this increase is directly attributable to COVID-19 or whether the pandemic indirectly (via staff shortages or breaches in infection prevention measures) led to this increase, remains unclear. The objectives of this study were to assess
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Antimicrobial use of patients with sexually transmitted infection symptoms prior to presentation at five health facilities in Southern Ghana Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-13 Naiki Attram, Helena Dela, Eric Behene, Nicholas N.A. Kyei, Karen Ocansey, Jennifer N. Yanney, Edward O. Nyarko, Kennedy K. Addo, Kwadwo A. Koram, Anne Fox, Andrew Letizia, Terrel Sanders
Unregulated and inappropriate antimicrobial use are major contributors to the evolution of antimicrobial resistance worldwide. It is important to monitor and collect data on the use of antibiotics at health facilities and in the general population in order to support antimicrobial stewardship programs. As part of a gonorrhea surveillance study that was conducted from June 2012 to Jan 2018, we administered
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Long-term exposure to food-grade disinfectants causes cross-resistance to antibiotics in Salmonella enterica serovar Typhimurium strains with different antibiograms and sequence types Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-13 Ricardo A. Wu-Chen, Jinsong Feng, Mohamed Elhadidy, Reshma B. Nambiar, Xinyu Liao, Min Yue, Tian Ding
Disinfectants are important in the food industry to prevent the transmission of pathogens. Excessive use of disinfectants may increase the probability of bacteria experiencing long-term exposure and consequently resistance and cross-resistance to antibiotics. This study aims to investigate the cross-resistance of multidrug-resistant, drug-resistant, and drug-susceptible isolates of Salmonella enterica
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Healthcare workers’ compliance with the catheter associated urinary tract infection prevention guidelines: an observational study in Yemen Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-10 Khaled Mohammed Al-Sayaghi, Talal Ali Hussein Alqalah, Sameer Abdulmalik Alkubati, Sultan Abdulwadoud Alshoabi, Mohammed Alsabri, Gamil Ghaleb Alrubaiee, Mokhtar Abdo Almoliky, Khalil A. Saleh, Anas Khaled Al-Sayaghi, Rami A. Elshatarat, Zyad T. Saleh, Ahmad Mahmoud Saleh, Hassanat Ramadan Abdel-Aziz
Catheter-associated urinary tract infection is a global problem but it can be prevented with the appropriate implementation of evidence-based guidelines. This study was conducted to assess the level of compliance of healthcare workers with the catheter-associated urinary tract infection prevention guidelines during the insertion of a urinary catheter. An observational study using a descriptive cross-sectional
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Description of a nationwide structure for monitoring nosocomial outbreaks of (highly resistant) microorganisms in the Netherlands: characteristics of outbreaks in 2012–2021 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-08 Sjoukje HS Woudt, Annelot F Schoffelen, Florine NJ Frakking, E Ascelijn Reuland, Juliëtte A Severin, Marije den Drijver, Anja Haenen, Marga MG Nonneman, Daan W Notermans, Desiree CM aan de Stegge, Sacha F de Stoppelaar, Christina MJE Vandenbroucke-Grauls, Sabine C de Greeff
Before 2012, established national surveillance systems in the Netherlands were not able to provide a timely, comprehensive epidemiological view on nosocomial outbreaks. The Healthcare-associated Infections and AntiMicrobial Resistance Monitoring Group (SO-ZI/AMR) was initiated in 2012 for timely national nosocomial outbreak monitoring and risk assessment. This paper aims to describe the achievements
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Epidemiology of multidrug-resistant Klebsiella pneumoniae infection in clinical setting in South-Eastern Asia: a systematic review and meta-analysis Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-07 Adamu Salawudeen, Yakubu Egigogo Raji, Garba Gidandawa Jibo, Mohd Nasir Mohd Desa, Hui-min Neoh, Siti Norbaya Masri, Sabrina Di Gregorio, Tengku Zetty Maztura Tengku Jamaluddin
The rising prevalence of multidrug-resistant (MDR) and extended-spectrum beta lactamase-resistant (ESBL) Klebsiella pneumoniae (K. pneumoniae) is an important global public health challenge. This threat is even more pertinent in clinical settings. Morbidity and mortality associated with this condition are alarming particularly in the developing regions of the world. A comprehensive evaluation of the
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Gamified antimicrobial decision support app (GADSA) changes antibiotics prescription behaviour in surgeons in Nigeria: a hospital-based pilot study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-06 Susanne Luedtke, Caroline Wood, Olajumoke Olufemi, Patrick Okonji, Eneyi E. Kpokiri, Anwar Musah, Funmi Bammeke, Bamidele Mutiu, Rufus Ojewola, Olufemi Bankole, Adesoji Ademuyiwa, Chibuzo Ekumankama, Ayibanoah Theophilus, Neni Aworabhi-Oki, Laura Shallcross, Andreea Molnar, Sue Wiseman, Andrew Hayward, Georgiana Birjovanu, Carmen Lefevre, Stylianos Petrou, Folasade Ogunsola, Patty Kostkova
Surgical Antibiotic Prophylaxis (SAP) in Nigeria is often not evidence based. The aim of this study is to test if the GADSA application can change prescription behaviour of surgeons in Nigeria. In addition, the study aims to identify AMS strategies and policies for the future. The GADSA gamified decision support app uses WHO and Sanford prescribing guidelines to deliver real-time persuasive technology
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The economic burden of cardiac implantable electronic device infections in Alberta, Canada: a population-based study using validated administrative data Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-05 Elissa Rennert-May, Derek Chew, Kristine Cannon, Zuying Zhang, Stephanie Smith, Teagan King, Derek V. Exner, Oscar E. Larios, Jenine Leal
Cardiac implantable electronic devices (CIED) are being inserted with increasing frequency. Severe surgical site infections (SSI) that occur after device implantation substantially impact patient morbidity and mortality and can result in multiple hospital admissions and repeat surgeries. It is important to understand the costs associated with these infections as well as healthcare utilization. Therefore
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Patterns and outcomes of health-care associated infections in the medical wards at Bugando medical centre: a longitudinal cohort study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-05 Maliha I. Kassam, Vitus Silago, Prisca Damiano, Bahati Wajanga, Jeremiah Seni, Stephen E. Mshana, Samuel Kalluvya
The burden of healthcare associated infections (HCAIs) in low- and middle-income countries (LMICs) remains underestimated due to diagnostic complexity and lack of quality surveillance systems. We designed this study to determine clinical diagnosis, laboratory-confirmed, associated factors and risks of HCAIs. This hospital-based longitudinal cohort study was conducted between March and June 2022 among
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Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-12-02 Xiaoju Ma, Qiangsheng He, Youpeng Chen, Yan Lu, Ping Zhu, Ji Zhang, Wen-sen Chen, Yongxiang Zhang, Wei-hong Zhang, Chuanlong Zhu, Qiang Li, Zhanjie Li
It is controversial whether antibiotic should be used prophylactically 48 h after pancreatic surgery. Hence, the association of antibiotic prophylaxis (AP) after 48 h postoperatively with the incidence of surgical site infections (SSIs) and other healthcare-associated infections (HAIs) in patients receiving pancreatic surgery was evaluated. A retrospective cohort analysis was performed on 1073 patients
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Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-29 Claudia Recanatini, Corine H. GeurtsvanKessel, Suzan D. Pas, Els M. Broens, Martje Maas, Rosa van Mansfeld, Anne J. G. Mutsaers-van Oudheusden, Miranda van Rijen, Emile F. Schippers, Arjan Stegeman, Adriana Tami, Karin Ellen Veldkamp, Hannah Visser, Andreas Voss, Marjolijn C. A. Wegdam-Blans, Heiman F. L. Wertheim, Peter C. Wever, Marion P. G. Koopmans, Jan A. J. W. Kluytmans, Marjolein F. Q. Kluytmans-van
We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed
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Acinetobacter baumannii: assessing susceptibility patterns, management practices, and mortality predictors in a tertiary teaching hospital in Lebanon Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-29 Rania Itani, Hani M. J. Khojah, Samar Karout, Deema Rahme, Lara Hammoud, Reem Awad, Rana Abu-Farha, Tareq L. Mukattash, Hamza Raychouni, Abdalla El-Lakany
Acinetobacter baumannii is a major nosocomial pathogen capable of causing life-threatening infections. This bacterium is highly resistant to antibiotics and associated with high mortality rates. Therefore, this study aimed to evaluate A. baumannii's susceptibility patterns to antimicrobials, assess the appropriateness of the initiated antimicrobial therapy, determine the mortality rate, and identify
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Effectiveness of tailored screening for multidrug-resistant organisms upon admission to an intensive care unit in the United Arab Emirates Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-28 Sungsoo Park, Heesuk Kim, Katrine K. Gatchalian, Hyeyoung Oh
Multidrug-resistant organism (MDRO) screening may identify high-risk patients for MDRO infection and curb the spread of these resistant pathogens. However, the heterogeneous practices in MDRO screening and the diversity of MDRO risk factors necessitate a tailored approach for successful implementation. This study aimed to evaluate the performance of tailored MDRO screening in predicting MDRO carriage
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Association between the introduction of a national targeted intervention program and the incidence of surgical site infections in Swiss acute care hospitals Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-24 Marcus Eder, Rami Sommerstein, Arlette Szelecsenyi, Alexander Schweiger, Matthias Schlegel, Andrew Atkinson, Stefan P. Kuster, Danielle Vuichard-Gysin, Nicolas Troillet, Andreas F. Widmer
In Switzerland, the national surgical site infection (SSI) surveillance program showed a modest decrease in SSI rates for different procedures over the last decade. The study aimed to determine whether a multimodal, targeted intervention program in addition to existing SSI surveillance is associated with decreased SSI rates in the participating hospitals. Prospective multicenter pre- and postintervention
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Evaluation of a novel surface-coating formulation with time-extended antimicrobial activity for healthcare environment disinfection Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-23 Roberto Bruno Maria Marano, Diana Merezhko, Keren Anat Resnick, Jacob Moran-Gilad, Yonatan Oster
The importance of environmental contamination in the transmission of pathogens among hospitalized patients is universally recognized, and disinfection of surfaces is a widely accepted modality for reducing healthcare-associated infections. Nevertheless, hospital disinfection is still suboptimal. In this study, we evaluated the sustained effects of the novel formulation OxiLast™ which extends the antimicrobial
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Estimating antibiotics consumption in a tertiary care hospital in Islamabad using a WHO’s defined daily dose methodology Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-23 Naila Jabeen, Waseem Ullah, Javeria Khalid, Zia Samad
Antibiotics have helped to reduce the incidence of common infectious diseases in all modern healthcare systems, but improper use of antibiotics including their overuse and misuse can change the bacteria so much that antibiotics don’t work against them. In case of developing imposable selective pressure with regard to the proportion of hospitalized patients who receive antibiotics, the quantity of antibiotics
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Protocols, policies and practices for antimicrobial stewardship in hospitalized patients in least-developed and low-income countries: a systematic review Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-23 Grace Wezi Mzumara, Michael Mambiya, Pui-Ying Iroh Tam
We aimed to identify interventions used to implement antimicrobial stewardship practices among hospitalized patients in least-developed countries. The research team searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for studies of AMS interventions in the least developed and low-income countries, published between 2000 and 2023. Included studies had a population of hospitalized
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Association between quality of governance, antibiotic consumption, and antimicrobial resistance: an analysis of Italian regions. Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-21 Andrea Maugeri,Martina Barchitta,Antonella Agodi
BACKGROUND Emerging research has provided evidence suggesting the potential influence of governance on the development and spread of antimicrobial resistance (AMR), accounting for significant disparities observed both between and within countries. In our study, we conducted an ecological analysis to investigate the relationship between governance quality, antibiotic consumption, and AMR across Italian
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Clinical significance and burden of carbapenem-resistant Enterobacterales (CRE) colonization acquisition in hospitalized patients Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-20 Nasreen Hassoun-Kheir, Khetam Hussien, Marianne Karram, Maram Saffuri, Sally Badaan, Shani Peleg, Worood Aboelhega, Sigal Warman, Tamar Alon, Dina Pollak, Moran Szwarcwort Cohen, Mical Paul
Carbapenem-resistant Enterobacterales (CRE) infections have a significant morbidity and mortality toll. The clinical significance and associated burden of CRE colonization rather than infection state are not frequently investigated. We aimed to assess the outcomes of CRE colonized patients compared to matched controls. A secondary analysis of a 1:2 matched case–control study at a tertiary hospital
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Microbiological trends and mortality risk factors of central line-associated bloodstream infections in an academic medical center 2015–2020 Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-19 Marwan Jabr Alwazzeh, Amani Alnimr, Samia A. Al Nassri, Sara M. Alwarthan, Mashael Alhajri, Bashayer M. AlShehail, Mahdi Almubarak, Nada S. Alghamdi, Haytham A. Wali
Despite tremendous efforts to prevent central line-associated bloodstream infections, they still remain life-threatening complications among hospitalized patients with significant morbidity and mortality worldwide. The emerging antibiotic-resistant bacteria and other risk factors, including patient comorbidities, complicate patient management. A single-center retrospective observational study was conducted
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A comprehensive point prevalence survey of the quality and quantity of antimicrobial use in Chinese general hospitals and clinical specialties Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-16 Yonghong Xiao, Xing Xin, Yunbo Chen, Qing Yan
Antimicrobial resistance (AMR) is a serious, worldwide public health crisis. Surveillance of antimicrobial use forms part of an essential strategy to contain AMR. We aimed to conduct a national point prevalence survey (PPS) on antimicrobial use, and to compare this data with similar international surveillance programs to provide a reference for future AMR strategy development in China. Twenty general
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Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-13 Marianna Meschiari, Shaniko Kaleci, Martina Del Monte, Andrea Dessilani, Antonella Santoro, Francesco Scialpi, Erica Franceschini, Gabriella Orlando, Adriana Cervo, Morselli Monica, Fabio Forghieri, Claudia Venturelli, Enrico Ricchizzi, Johanna Chester, Mario Sarti, Giovanni Guaraldi, Mario Luppi, Cristina Mussini
Vancomycin-resistant enterococcus (VRE) was the fastest growing pathogen in Europe in 2022 (+ 21%) but its clinical relevance is still unclear. We aim to identify risk factors for acquired VRE rectal colonization in hematological patients and evaluate the clinical impact of VRE colonization on subsequent infection, and 30- and 90-day overall mortality rates, compared to a matched control group. A retrospective
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A qualitative study of infection prevention and control practices in the maternal units of two Ghanaian hospitals Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-13 Gifty Sunkwa-Mills, Kodjo Senah, Mette Breinholdt, Matilda Aberese-Ako, Britt Pinkowski Tersbøl
Healthcare-associated infections (HAIs) remain a common challenge in healthcare delivery, with a significant burden in low- and middle-income countries. Preventing HAIs has gained enormous attention from policy makers and healthcare managers and providers, especially in resource-limited settings. Despite policies to enforce infection prevention and control (IPC) measures to prevent HAIs, IPC compliance
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Infection with Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae: clinical, virulence and molecular epidemiological characteristics Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-13 Linlin Li, Shan Li, Xianzhen Wei, Zhaolu Lu, Xue Qin, Meng Li
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually becoming the dominant nosocomial pathogens in the healthcare setting. A retrospective study was conducted on patients with CR-KP from July 2021 to May 2022 in a teaching hospital. We identified bacterial isolates, collected the clinical data, and performed antimicrobial susceptibility testing, hypermucoviscosity string
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Epidemiology of extended-spectrum β-lactamase–producing Enterobacterales infection in kidney transplant recipients Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-10 Oranuch Promsuwan, Kumthorn Malathum, Atiporn Ingsathit
Extended-spectrum b-lactamase (ESBL)-producing gram-negative bacilli (ESBL-GNB) are the most important pathogenic bacteria infecting kidney transplant patients. Kidney transplantation has been shown to be a risk factor for nosocomial ESBL-GNB bacteremia. The aims of this study were to describe the epidemiology of ESBL-GNB acquisition and to identify factors associated with ESBL-GNB infection in kidney
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Epidemiological manifestations and impact of healthcare-associated infections in Libyan national hospitals Antimicrob. Resist. Infect. Control (IF 5.5) Pub Date : 2023-11-06 Mohamed Ali Daw, Mahamat Hassabarassoul Mahamat, Said Emhamed Wareg, Abdallah H El-Bouzedi, Mohamed Omar Ahmed
Healthcare-associated infection is a serious global problem, particularly in developing countries. In North African countries, comprehensive research on the incidence and effects of such infections is rare. This study evaluated the epidemiology and determined the impact of healthcare-associated infections in Libyan national teaching hospitals. A prospective longitudinal study was carried out in Libya’s