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Model matchmaking Lab Anim. (IF 9.6) Pub Date : 2021-01-20 Ellen P. Neff
Building platforms to connect clinicians and model organism researchers.
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A word from the Editors on Protocol Review Lab Anim. (IF 9.6) Pub Date : 2021-01-12
The lab animal community lost Dr. Jerald Silverman on November 14, 2020 to COVID-19. Here, we reflect on Jerry and his long-running and well-loved Protocol Review column.
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Replacement of surgical vasectomy through the use of wild-type sterile hybrids Lab Anim. (IF 9.6) Pub Date : 2021-01-04 Chris Preece; Samy Alghadban; Amine Bouchareb; Daniela Moralli; Daniel Biggs; Benjamin Davies
For the production and rederivation of mouse strains, pseudopregnant female mice are used for embryo transfer and serve as surrogate mothers to support embryo development to term. Vasectomized males are commonly used to render pseudopregnancy in females, generated by surgical procedures associated with considerable pain and discomfort. Genetically modified mouse strains with a sterility phenotype provide
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CRISPR gets crunchy Lab Anim. (IF 9.6) Pub Date : 2020-12-07 Jim Kling
New wrinkles on the Nobel prize-winning method are creating new efficiencies, and new research opportunities.
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A fish is not a mouse: understanding differences in background genetics is critical for reproducibility Lab Anim. (IF 9.6) Pub Date : 2020-12-02 Marcus J. Crim; Christian Lawrence
Poorly controlled background genetics in animal models contributes to the lack of reproducibility that is increasingly recognized in biomedical research. The laboratory zebrafish, Danio rerio, has been an important model organism for decades in many research areas, yet inbred strains and traditionally managed outbred stocks are not available for this species. Sometimes incorrectly referred to as ‘inbred
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Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice Lab Anim. (IF 9.6) Pub Date : 2020-11-30 Yan-Yuen Poon; Ching-Yi Tsai; Ya‐Hui Huang; Jacqueline C. C. Wu; Samuel H. H. Chan; Julie Y. H. Chan
Employment of anesthetics, including isoflurane, though mandatory in animal experiments, is often regarded as a major limitation because results obtained with anesthetics may be different from those obtained under a conscious state. This study re-visits two issues related to the use of isoflurane. First, does isoflurane exert depression equally on all aspects of cardiovascular functions and their regulations
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Experimental murine arteriovenous fistula model to study restenosis after transluminal angioplasty Lab Anim. (IF 9.6) Pub Date : 2020-10-20 Chuanqi Cai; Chenglei Zhao; Sreenivasulu Kilari; Amit Sharma; Avishek K. Singh; Michael L. Simeon; Avanish Misra; Yiqing Li; Sanjay Misra
Percutaneous transluminal angioplasty (PTA) is a very common interventional treatment for treating stenosis in arteriovenous fistula (AVF) used for hemodialysis vascular access. Restenosis occurs after PTA, resulting in vascular lumen loss and a decrease in blood flow. Experimental animal models have been developed to study the pathogenesis of stenosis, but there is no restenosis model after PTA of
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Where the wild zebrafish are Lab Anim. (IF 9.6) Pub Date : 2020-10-15 Ellen P. Neff
Journeying into the field to study a model organism in its natural habitats.
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Publisher Correction: Following the fate of cells in vivo Lab Anim. (IF 9.6) Pub Date : 2020-10-09 Jim Kling
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: The quest for an animal model of coral health and disease Lab Anim. (IF 9.6) Pub Date : 2020-10-09 Ellen P. Neff
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: Set lasers to image Lab Anim. (IF 9.6) Pub Date : 2020-10-09 Ellen P. Neff
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Know Your Model: Microbiota & phenotypes Lab Anim. (IF 9.6) Pub Date : 2020-10-08 Michelle N. Perry; Susan M. Bello; Cynthia L. Smith
Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mutant phenotypes.
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A CRISPR cut for messenger RNAs Lab Anim. (IF 9.6) Pub Date : 2020-10-05 Rebecca Leech; Karuna Sampath
To achieve knockdown rather than knockout of particular genes, a new paper demonstrates a CRISPR/Cas13 method that can efficiently edit mRNA in zebrafish, medaka, killifish, and mouse embryos.
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A fluorescent biomarker for liver disease. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Alexandra Le Bras
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To report or not to report? Regulations win, despite the unavoidable nature of renovations. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Emily Weston,Courtney Parnell Nesline
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Construction effects on laboratory animals: Communication is key. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Karen L Rogers,Susan Glowacz
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Under construction: how to deal with noise and vibration in the animal facility? Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Jerald Silverman
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"Off-target" effect of tamoxifen on the brain. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Alexandra Le Bras
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CRISPR in cephalopods yields the first knockout squid. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Ellen P Neff
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Generation of AAV vectors for selective neuronal targeting. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Alexandra Le Bras
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A Word from OLAW. Lab Anim. (IF 9.6) Pub Date : 2020-09-21 Patricia Brown
In response to the issues posed in this scenario, the National Institutes of Health - Office of Laboratory Animal Welfare (NIH-OLAW) provides the following clarification:
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Taking an interest in small animal research programs. Lab Anim. (IF 9.6) Pub Date : 2020-09-21 Christopher S Keator
There are administrative challenges inherent to any animal research program – from hiring vets and care staff to approving and overseeing protocols to reporting to the relevant authorities. Small institutions, with limited resources and available staff compared to ‘research juggernauts,’ can have extra hurdles to cross when administering their animal research programs.
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The basics of biocontainment. Lab Anim. (IF 9.6) Pub Date : 2020-09-09 Jim Kling
Studying potentially dangerous microbes in animal models of the disease they cause takes some extra considerations, as researchers and staff must perform their work under the careful restrictions of different biosafety level laboratories.
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Creating space to build emotional resilience in the animal research community. Lab Anim. (IF 9.6) Pub Date : 2020-08-31 Jordi L Tremoleda,Angela Kerton
The relationships between individuals and the research animals they work with can enhance animal welfare, but they also involve a moral cost to staff. Securing a safe space to communicate openly about animal welfare & research and acknowledge its emotional impacts is crucial. In this Comment, we reflect on emotional resilience and provide resources available to help manage the emotional burden of working
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The astute resident and the IACUC. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Deyanira Santiago,Ann Marie Dinkel
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We've got 99 problems but prompt reporting ain't one of them. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Kim E Saunders,Vickie Jarrell,Philip R Streeter
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Residents and regulations-always an adventure. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Llana A Galex,Steven Shipley
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Does a problem involving a pet cat require a report to regulators? Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Jerald Silverman
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A systems biology approach to understand the effects of diet on lifespan. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Alexandra Le Bras
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Arriving again: 10 years on, ARRIVE 2.0 offers a simplified set of reporting guidelines. Lab Anim. (IF 9.6) Pub Date : 2020-10-01 Alla Katsnelson
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A day in the life of a mosquito insectary team: pushing for solutions to mosquito-borne diseases. Lab Anim. (IF 9.6) Pub Date : 2020-08-17 Robyn R Raban,Omar S Akbari
Robyn Raban and Omar Akbari describe a day in the life of the mosquito insectary team at the University of California, San Diego, outlining the procedures, goals, and types of systems they are engineering to control mosquito-transmitted diseases.
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Set lasers to image. Lab Anim. (IF 9.6) Pub Date : 2020-08-12 Ellen P Neff
Engineers and neuroscientists working to advance multiphoton microscopy are pushing the depths, speeds, and scales of in vivo imaging.
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Zebrafish exhibit associative learning for an aversive robotic stimulus. Lab Anim. (IF 9.6) Pub Date : 2020-08-10 Simone Macrì,Mert Karakaya,Chiara Spinello,Maurizio Porfiri
Zebrafish have quickly emerged as a species of choice in preclinical research, holding promise to advance the field of behavioral pharmacology through high-throughput experiments. Besides biological and heuristic considerations, zebrafish also constitute a fundamental tool that fosters the replacement of mammals with less sentient experimental subjects. Notwithstanding these features, experimental
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Filling in the slate with transcriptomes for mice across ages. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Ellen P Neff
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Medaka fish provide new insights into osteoporosis. Lab Anim. (IF 9.6) Pub Date : 2020-09-01 Alexandra Le Bras
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Syrian hamsters as a small animal model for COVID-19 research. Lab Anim. (IF 9.6) Pub Date : 2020-08-01 Alexandra Le Bras
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