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PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-24 Tong Hua, Erliang Kong, Hailing Zhang, Jinfang Lu, Kesheng Huang, Ruifeng Ding, Haowei Wang, Jian Li, Chaofeng Han, Hongbin Yuan
Microglia induced chronic inflammation is the critical pathology of Neuropathic pain (NP). Metabolic reprogramming of macrophage has been intensively reported in various chronic inflammation diseases. However, the metabolic reprogramming of microglia in chronic pain remains to be elusive. Here, we reported that immuno-metabolic markers (HIF-1α, PKM2, GLUT1 and lactate) were related with increased expression
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Sleep promotes T-cell migration towards CCL19 via growth hormone and prolactin signaling in humans Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-16 Estefanía Martínez-Albert, Nicolas D. Lutz, Robert Hübener, Stoyan Dimitrov, Tanja Lange, Jan Born, Luciana Besedovsky
Sleep strongly supports the formation of adaptive immunity, e.g., after vaccination. However, the underlying mechanisms remain largely obscure. Here we show in healthy humans that sleep compared to nocturnal wakefulness specifically promotes the migration of various T-cell subsets towards the chemokine CCL19, which is essential for lymph-node homing and, thus, for the initiation and maintenance of
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Toward a dynamic immunopsychiatry Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-15 Daniel P. Moriarity, George M. Slavich
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Early corticosteroid treatment enhances recovery from SARS-CoV-2 induced loss of smell in hamster Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-15 Laetitia Merle-Nguyen, Ophélie Ando-Grard, Clara Bourgon, Audrey St Albin, Juliette Jacquelin, Bernard Klonjkowski, Sophie Le Poder, Nicolas Meunier
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Low-dose interleukin 2 antidepressant potentiation in unipolar and bipolar depression: Safety, efficacy, and immunological biomarkers Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-15 Sara Poletti, Raffaella Zanardi, Alessandra Mandelli, Veronica Aggio, Annamaria Finardi, Cristina Lorenzi, Giovanna Borsellino, Matteo Carminati, Elena Manfredi, Enrico Tomasi, Sara Spadini, Cristina Colombo, Hemmo A. Drexhage, Roberto Furlan, Francesco Benedetti
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The miR-25802/KLF4/NF-κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer’s disease Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-13 Kaiyue Zhao, Jianghong Liu, Ting Sun, Li Zeng, Zhongdi Cai, Zhuorong Li, Rui Liu
Microglia-mediated neuroinflammation plays a critical role in the occurrence and progression of Alzheimer’s disease (AD). In recent years, studies have increasingly explored microRNAs as biomarkers and treatment interventions for AD. This study identified a novel microRNA termed miR-25802 from our high-throughput sequencing dataset of an AD model and explored its role and the underlying mechanism.
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Affective dysfunction mediates the link between neuroimmune markers and the default mode network functional connectivity, and the somatic symptoms in somatic symptom disorder Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-13 Bumhee Park, Seulgi Lee, Yu Na Jang, Hye Youn Park
Somatic symptom disorder (SSD) is characterized by physical symptoms and associated functional impairments that are often comorbid with depression and anxiety disorders. In this study, we explored relationships between affective symptoms and the functional connectivity of the default mode network (DMN) in SSD patients, as well as the impact of peripheral inflammation. We employed mediation analyses
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Interferon-β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-13 Hina Singh, Jeffrey Koury, Ricky Maung, Amanda J. Roberts, Marcus Kaul
Human immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy (cART). HIV-1 activates the innate immune system, including the production of type 1 interferons (IFNs) α and β. Transgenic mice expressing HIV-1 envelope glycoprotein
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Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-12 Fumiko Murata, Megumi Maeda, Keitaro Murayama, Tomohiro Nakao, Haruhisa Fukuda
The associations between COVID-19 vaccination and post-COVID psychiatric disorders are unclear. Furthermore, it is uncertain if these associations differ depending on the dominant SARS-CoV-2 variant at the time of infection. This retrospective cohort study aimed to clarify the associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough infection according to the
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Peri-operative individually tailored psychological intervention in breast cancer patients improves psychological indices and molecular biomarkers of metastasis in excised tumors Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-10 Tsipi Hanalis-Miller, Itay Ricon-Becker, Nahida Sakis, Estherina Trachtenberg, Frida Ohayon, Sonya Wadhawker, Yehudit Birnboim, Ada Magen, Eran Sharon, Ricardo Tarrasch, Gil Goldzweig, Steve W. Cole, Rebecca Jacoby, Shamgar Ben-Eliyahu
Perioperative stress and inflammatory signaling can invigorate pro-metastatic molecular processes in patients' tumors, potentially worsening long-term survival. Yet, it is unknown whether pre-operative psychotherapeutic interventions can attenuate such effects. Herein, three weeks before surgery, forty women diagnosed with stage I-III invasive ductal/lobular breast carcinoma were randomized to a 6-week
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Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-08 Xing Ge, Minmin Hu, Menglu Zhou, Xiaoli Fang, Xi Chen, Deqin Geng, Li Wang, Xiaoying Yang, Huimei An, Meng Zhang, Danhong Lin, Mingxuan Zheng, Xiaoying Cui, Qing Wang, Yuqing Wu, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
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From hormones to behavior through microglial mitochondrial function Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-08 Maryam Ardalan, Carina Mallard
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A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-08 Jake Sondag Boles, Maeve E. Krueger, Janna E. Jernigan, Cassandra L. Cole, Noelle K. Neighbarger, Oihane Uriarte Huarte, Malú Gámez Tansey
The gut and brain are increasingly linked in human disease, with neuropsychiatric conditions classically attributed to the brain showing an involvement of the intestine and inflammatory bowel diseases (IBDs) displaying an ever-expanding list of neurological comorbidities. To identify molecular systems that underpin this gut-brain connection and thus discover therapeutic targets, experimental models
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Systemic inflammation and risk of Parkinson’s disease: A prospective cohort study and genetic analysis Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-07 Chunyu Li, Bin Ke, Jianhai Chen, Yi Xiao, Shichan Wang, Rirui Jiang, Xiaoting Zheng, Junyu Lin, Jingxuan Huang, Huifang Shang
Multiple evidence has suggested the complex interplay between Parkinson’s disease (PD) and systemic inflammation marked by C-reactive protein (CRP) and interleukin 6 (IL-6). Nevertheless, the findings across studies have shown inconsistency, and the direction of the effect remains controversial. Here, we aimed to explore the link between CRP and IL-6 and the risk of PD. Based on data from the UK Biobank
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Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-07 H.B. Duindam, D. Mengel, M. Kox, J.C. Göpfert, R.P.C. Kessels, M. Synofzik, P. Pickkers, W.F. Abdo
Cognitive deficits are increasingly recognized as a long-term sequela of severe COVID-19. The underlying processes and molecular signatures associated with these long-term neurological sequalae of COVID-19 remain largely unclear, but may be related to systemic inflammation-induced effects on the brain. We studied the systemic inflammation-brain interplay and its relation to development of long-term
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Role of pyroptosis in the pathogenesis of various neurological diseases Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-07 Abiola Oladapo, Thomas Jackson, Jueliet Menolascino, Palsamy Periyasamy
Pyroptosis, an inflammatory programmed cell death process, has recently garnered significant attention due to its pivotal role in various neurological diseases. This review delves into the intricate molecular signaling pathways governing pyroptosis, encompassing both caspase-1 dependent and caspase-1 independent routes, while emphasizing the critical role played by the inflammasome machinery in initiating
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Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-05 Bin Mei, Xiaoxia Xu, Juntao Weng, Yueyue Yang, Peng Wang, Gaolin Qiu, Chi Zhang, Qunlin Zhang, Yao Lu, Xuesheng Liu
Glutamate metabolism disorder is an important mechanism of sepsis-associated encephalopathy (SAE). Astrocytes regulate glutamate metabolism. In septic mice, α2A adrenoceptor (α2A-AR) activation in the central nervous system provides neuroprotection. α2A-ARs are expressed abundantly in hippocampal astrocytes. This study was performed to determine whether hippocampal astrocytic α2A-AR activation confers
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Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-05 Danrui Zhao, Yiqing Wu, Hang Zhao, Fengji Zhang, Junting Wang, Yiying Liu, Jing Lin, Yirui Huang, Wenhao Pan, Jiahui Qi, Nan Chen, Xu Yang, Wen Xu, Zhiqian Tong, Jianhua Cheng
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Hyperactive lateral habenula mediates the comorbidity between rheumatoid arthritis and depression-like behaviors Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-04 Peihui Wu, Wenchang Li, Rongke Lv, Xin Cheng, Fan Lian, Wenbao Cai, Yubo Hu, Yanni Zeng, Bizhen Ke, Yi Chen, Zaohui Ma, Meiqi Ma, Weiping Dai, Pei Xia, Yangyang Lin, Wei-Jye Lin, Xiaojing Ye
Rheumatoid arthritis (RA) patients have a high prevalence for depression. On the other hand, comorbid with depression is associated with worse prognosis for RA. However, little is known about the underlying mechanisms for the comorbidity between RA and depression. It remains to be elucidated which brain region is critically involved in the development of depression in RA, and whether alterations in
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KCNA2 IgG autoimmunity in neuropsychiatric diseases Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-02 Friederike A. Arlt, Ramona Miske, Marie-Luise Machule, Peter Broegger Christensen, Swantje Mindorf, Bianca Teegen, Kathrin Borowski, Maria Buthut, Rosa Rößling, Elisa Sánchez-Sendín, Scott van Hoof, César Cordero-Gómez, Isabel Bünger, Helena Radbruch, Andrea Kraft, Ilya Ayzenberg, Jaqueline Klausewitz, Niels Hansen, Charles Timäus, Peter Körtvelyessy, Thomas Postert, Kirsten Baur-Seack, Constanze Rost
Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice. We retrospectively collected comprehensive clinical and paraclinical data of 35 patients with KCNA2 IgG autoantibodies detected in cell-based
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Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-02 Clara Sanchez, Cécilia Colson, Nadine Gautier, Pascal Noser, Juliette Salvi, Maxime Villet, Lucile Fleuriot, Caroline Peltier, Pascal Schlich, Frédéric Brau, Ariane Sharif, Ali Altintas, Ez-Zoubir Amri, Jean-Louis Nahon, Nicolas Blondeau, Alexandre Benani, Romain Barrès, Carole Rovère
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Loss of interleukin 1 signaling causes impairment of microglia- mediated synapse elimination and autistic-like behaviour in mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-02 Antonella Borreca, Cristina Mantovani, Genni Desiato, Irene Corradini, Fabia Filipello, Chiara Adriana Elia, Francesca D'Autilia, Giulia Santamaria, Cecilia Garlanda, Raffaella Morini, Davide Pozzi, Michela Matteoli
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Lower complement C1q levels in first-episode psychosis and in schizophrenia Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-01 Marja Koskuvi, Susmita Malwade, Jessica Gracias Lekander, Elin Hörbeck, Sanna Bruno, Jessica Holmen Larsson, Aurimantas Pelanis, Anniella Isgren, Anneli Goulding, Helena Fatouros-Bergman, Martin Schalling, Fredrik Piehl, Sophie Erhardt, Mikael Landen, Simon Cervenka, Funda Orhan, Carl M. Sellgren
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Response to comment on: Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206+ myeloid cells Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-01 Andrew J. Shepherd
Abstract not available
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Prospective associations of technostress at work, burnout symptoms, hair cortisol, and chronic low-grade inflammation Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-01 Helena C. Kaltenegger, Mathew D. Marques, Linda Becker, Nicolas Rohleder, Dennis Nowak, Bradley J. Wright, Matthias Weigl
Working conditions in the age of digitalization harbor risks for chronic stress and burnout. However, real-world investigations into biological effects of technostress, that is stress in the context of digital technology use, are sparse. This study prospectively assessed associations between technostress, general work stress, burnout symptoms, hair cortisol, and chronic low-grade inflammation. Hospital
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Macrophage is more than a bystander in peripheral sensitisation Brain Behav. Immun. (IF 15.1) Pub Date : 2024-02-01 Philip Chiu-Tsun Tang, Shujie Huang, Patrick Ming-Kuen Tang
Abstract not available
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Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-26 Milica Drapšin, Tereza Dočkal, Pavel Houdek, Martin Sládek, Kateryna Semenovykh, Alena Sumová
The choroid plexus (ChP) in the brain ventricles has a major influence on brain homeostasis. In this study, we aimed to determine whether the circadian clock located in ChP is affected by chronodisruption caused by misalignment with the external light/dark cycle and/or inflammation. Adult mPer2Luc mice were maintained in the LD12:12 cycle or exposed to one of two models of chronic chronodisruption
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Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-26 Laura M. Cox, Bruna K. Tatematsu, Lydia Guo, Danielle S. LeServe, Julia Mayrink, Marilia G. Oliveira, Dustin Donnelly, Roberta C. Fonseca, Luisa Lemos, Toby B. Lanser, Ana C. Rosa, Juliana R. Lopes, Luke A. Schwerdtfeger, Gabriela F.C. Ribeiro, Eduardo L.C. Lobo, Thais G. Moreira, Andre G. Oliveira, Howard L. Weiner, Rafael M. Rezende
Intestinal γδ T cells play an important role in shaping the gut microbiota, which is critical not only for maintaining intestinal homeostasis but also for controlling brain function and behavior. Here, we found that mice deficient for γδ T cells (γδ-/-) developed an abnormal pattern of repetitive/compulsive (R/C) behavior, which was dependent on the gut microbiota. Colonization of WT mice with γδ-/-
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Differences in the gut microbiome of young adults with schizophrenia spectrum disorder: using machine learning to distinguish cases from controls Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-26 Miranda Stiernborg, Stefanie Prast-Nielsen, Philippe A. Melas, Maria Skott, Vincent Millischer, Fredrik Boulund, Yvonne Forsell, Catharina Lavebratt
While an association between the gut microbiome and schizophrenia spectrum disorders (SSD) has been suggested, the existing evidence is still inconclusive. To this end, we analyzed bacteria and bacterial genes in feces from 52 young adult SSD patients and 52 controls using fecal shotgun metagenomic sequencing. Compared to controls, young SSD patients were found to have significantly lower α-diversity
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Accelerated neurodegeneration of basal forebrain cholinergic neurons in HIV-1 gp120 transgenic mice: Critical role of the p75 neurotrophin receptor Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-22 Andrew Speidell, Christy Agbey, Italo Mocchetti
Human Immunodeficiency Virus-1 (HIV) infection of the brain induces HIV-associated neurocognitive disorders (HAND). The set of molecular events employed by HIV to drive cognitive impairments in people living with HIV are diverse and remain not completely understood. We have shown that the HIV envelope protein gp120 promotes loss of synapses and decreases performance on cognitive tasks through the p75
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Exposure to parental depression in adolescence and proinflammatory phenotypes 20 years later Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-18 Katherine B. Ehrlich, Manuela L. Celia-Sanchez, Tianyi Yu, Nia Heard-Garris, Edith Chen, Gregory E. Miller, Gene H. Brody
Although the biological embedding model of adversity proposes that stressful experiences in childhood create a durable proinflammatory phenotype in immune cells, research to date has relied on study designs that limit our ability to make conclusions about whether the phenotype is long-lasting. The present study leverages an ongoing 20-year investigation of African American youth to test research questions
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The fatigue-inducing effects of cancer and its therapy are characterized by decreased physical activity in the absence of any motivational deficit Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-18 Thien T. Phan, Kiersten S. Scott, Brandon Chelette, A. Phillip West, Robert Dantzer
Although cancer and its therapy are well known to be associated with fatigue, the exact nature of cancer-related fatigue remains ill-defined. We previously reported that fatigue-like behavior induced independently by tumor growth and by the chemotherapeutic agent cisplatin is characterized by reduced voluntary wheel running and an intact motivation to expand effort for food rewards. The present set
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Response to comment on: Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-17 Farida Sohrabji
Abstract not available
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Major stress in early childhood strengthens the association between peripheral inflammatory activity and corticostriatal responsivity to reward Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-19 Gregory E. Miller, Ann L. Carroll, Casey C. Armstrong, Michelle G. Craske, Richard E. Zinbarg, Susan Y. Bookheimer, Iris Ka-Yi Chat, Meghan Vinograd, Katherine S. Young, Robin Nusslock
Background Severe, chronic stress during childhood accentuates vulnerability to mental and physical health problems across the lifespan. To explain this phenomenon, the neuroimmune network hypothesis proposes that childhood stressors amplify signaling between peripheral inflammatory cells and developing brain circuits that support processing of rewards and threats. Here, we conducted a preliminary
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Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-18 Xue-Jing Lv, Su-Su Lv, Guo-Hong Wang, Yue Chang, Ya-Qi Cai, Hui-Zhu Liu, Guang-Zhou Xu, Wen-Dong Xu, Yu-Qiu Zhang
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Molecular underpinnings of programming by early-life stress and the protective effects of early dietary ω6/ω3 ratio, basally and in response to LPS: Integrated mRNA-miRNAs approach Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-17 Kitty Reemst, Nicola Lopizzo, Maralinde R. Abbink, Hendrik J. Engelenburg, Annamaria Cattaneo, Aniko Korosi
Early-life stress (ELS) exposure increases the risk for mental disorders, including cognitive impairments later in life. We have previously demonstrated that an early diet with low ω6/ω3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-induced cognitive impairments. Several studies have implicated the neuroimmune system in the ELS and diet mediated effects, but currently the molecular pathways
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Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-09 Carla B. Rodríguez-Moreno, Héctor Cañeque-Rufo, Miguel Flor-García, Julia Terreros-Roncal, Elena P. Moreno-Jiménez, Noemí Pallas-Bazarra, Carlo Bressa, Mar Larrosa, Fabio Cafini, María Llorens-Martín
The mammalian hippocampus can generate new neurons throughout life. Known as adult hippocampal neurogenesis (AHN), this process participates in learning, memory, mood regulation, and forgetting. The continuous incorporation of new neurons enhances the plasticity of the hippocampus and contributes to the cognitive reserve in aged individuals. However, the integrity of AHN is targeted by numerous pathological
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Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-11 Shangchen Yang, Ziqi Yuan, Yufei Zhu, Chensi Liang, Zhenlei Chen, Jie Zhang, Lige Leng
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Comment on: Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-14 Liqi Li
Abstract not available
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Blocking IL-17A prevents oxycodone-ineduced depression-like effects and elevation of IL-6 levels in the ventral tegmental area and reduces oxycodone-derived physical dependence in rats Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-08 Saadet Inan, Joseph J. Meissler, Shingo Bessho, Sonita Wiah, Cagla Tukel, Toby K. Eisenstein, Scott M. Rawls
Oxycodone is the most prescribed opioid for pain management and has been available in clinics for almost a century, but effects of chronic oxycodone have been studied less than morphine in preclinical and clinical studies. Newly developed depression has been coupled with chronic oxycodone use in a few clinical studies, but no preclinical studies have investigated the pathogenesis of oxycodone-induced
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Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-12 Colm Healy, Jonah Byrne, Subash Raj Suasi, Melanie Föcking, David Mongan, Eleftheria Kodosaki, Meike Heurich, Gerard Cagney, Kieran Wynne, Carrie E. Bearden, Scott W. Woods, Barbara Cornblatt, Daniel Mathalon, William Stone, Tyrone D. Cannon, Jean Addington, Kristin S. Cadenhead, Diana Perkins, Clark Jeffries, David Cotter
Background Immune dysregulation has been observed in patients with schizophrenia or first-episode psychosis, but few have examined dysregulation in those at clinical high-risk (CHR) for psychosis. The aim of this study was to examine whether the peripheral blood-based proteome was dysregulated in those with CHR. Secondly, we examined whether baseline dysregulation was related to current and future
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Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-06 Arthur Silveira Prudente, Sang Hoon Lee, Jueun Roh, Debora D. Luckemeyer, Cinder F. Cohen, Marie Pertin, Chul-Kyu Park, Marc R. Suter, Isabelle Decosterd, Jun-Ming Zhang, Ru-Rong Ji, Temugin Berta
Microglia, resident immune cells in the central nervous system, play a role in neuroinflammation and the development of neuropathic pain. We found that the stimulator of interferon genes (STING) is predominantly expressed in spinal microglia and upregulated after peripheral nerve injury. However, mechanical allodynia, as a marker of neuropathic pain following peripheral nerve injury, did not require
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ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-10 Emily F. Willis, Seung Jae Kim, Wei Chen, Melanie Nyuydzefe, Kelli P.A. MacDonald, Alexandra Zanin-Zhorov, Marc J. Ruitenberg, Jana Vukovic
Traumatic brain injury (TBI) results in prolonged and non-resolving activation of microglia. Forced turnover of these cells during the acute phase of TBI aids recovery, but the cell-intrinsic pathways that underpin the pro-repair phenotype of these repopulating microglia remain unclear. Here, we show that selective targeting of ROCK2 with the small molecule inhibitor KD025 impairs the proliferative
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Microbiota-microglia crosstalk between Blautia producta and neuroinflammation of Parkinson's disease: A bench-to-bedside translational approach Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-09 Jiaming Liu, Xinhuang Lv, Tao Ye, Ming Zhao, Zhibo Chen, Yang Zhang, Wenwen Yang, Huijia Xie, Lu Zhan, Liuzhu Chen, Wen-Chun Liu, Kuan-Pin Su, Jing Sun
Parkinson's disease (PD) is intricately linked to abnormal gut microbiota, yet the specific microbiota influencing clinical outcomes remain poorly understood. Our study identified a deficiency in the microbiota genus Blautia and a reduction in fecal short-chain fatty acid (SCFA) butyrate level in PD patients compared to healthy controls. The abundance of Blautia correlated with the clinical severity
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Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-06 Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wang
Emerging studies have demonstrated spinal microglia play a critical role in central sensitization and contribute to chronic pain. Although several mediators that contribute to microglia activation have been identified, the mechanism of microglia activation and its functionally diversified mechanisms in pathological pain are still unclear. Here we report that injured sensory neurons-derived Galectin-3
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Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice Brain Behav. Immun. (IF 15.1) Pub Date : 2024-01-03 Mark A.A. Harrison, Sara L. Morris, Grace A. Rudman, Daniel J. Rittenhouse, Chandler H. Monk, Siva S.V.P. Sakamuri, Md Mehedi Hasan, Mst Shamima Khatun, Hanyun Wang, Lucas P. Garfinkel, Elizabeth B. Norton, Sangku Kim, Jay K. Kolls, S. Michal Jazwinski, Ricardo Mostany, Prasad V,G. Katakam, Elizabeth B. Engler-Chiurazzi, Kevin J. Zwezdaryk
Risk factors contributing to dementia are multifactorial. Accumulating evidence suggests a role for pathogens as risk factors, but data is largely correlative with few causal relationships. Here, we demonstrate that intermittent murine cytomegalovirus (MCMV) infection of mice, alters blood brain barrier (BBB) permeability and metabolic pathways. Increased basal mitochondrial function is observed in
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Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-31 Deepthi Bannai, Martin Reuter, Rachal Hegde, Dung Hoang, Iniya Adhan, Swetha Gandu, Sovannarath Pong, Nick Raymond, Victor Zeng, Yoonho Chung, George He, Daqiang Sun, Theo G.M. van Erp, Jean Addington, Carrie E. Bearden, Kristin Cadenhead, Barbara Cornblatt, Daniel H. Mathalon, Thomas McGlashan, Clark Jeffries, Paulo Lizano
Background Choroid plexus (ChP) enlargement exists in first-episode and chronic psychosis, but whether enlargement occurs before psychosis onset is unknown. This study investigated whether ChP volume is enlarged in individuals with clinical high-risk (CHR) for psychosis and whether these changes are related to clinical, neuroanatomical, and plasma analytes. Methods Clinical and neuroimaging data from
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Association between doxycycline use and long-term functioning in patients with schizophrenia Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-31 Lot D. de Witte, Thomas Munk Laursen, Cheryl M. Corcoran, Trine Munk-Olsen, Veerle Bergink
Importance and objective The brain-penetrant tetracycline antibiotics, minocycline and doxycycline, have been proposed as potential candidate drugs for treatment of schizophrenia, based on preclinical studies and clinical trials. A potential long-term beneficial effect of these antibiotics for schizophrenia patients has not been investigated. This study was designed to determine if redemption of doxycycline
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Levels of cytokines in the cerebrospinal fluid of patients with psychotic disorders compared to individually matched healthy controls Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-29 Rose Jeppesen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Nina Vindegaard Sørensen, Ole Köhler-Forsberg, Kristin Skogstrand, Michael Eriksen Benros
Background Increased peripheral cytokine levels have been observed in patients with psychotic disorders; however, large high-quality studies with individually matched healthy controls have been lacking regarding cytokines in cerebrospinal fluid (CSF) of individuals with psychotic disorders. Methods Patients diagnosed with a non-organic, non-affective psychotic disorder (ICD-10: F20/22–29) within a
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Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-28 Rong-Jun Ni, Yi-Yan Wang, Wen-Jun Pu, Ying-Ying Wei, Jin-Xue Wei, Lian-Sheng Zhao, Xiao-Hong Ma
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Role of astrocyte senescence regulated by the non– canonical autophagy in the neuroinflammation associated to cerebral malaria Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-27 Fatima Hellani, Inès Leleu, Nasreddine Saidi, Nathalie Martin, Cécile Lecoeur, Elisabeth Werkmeister, David Koffi, François Trottein, Hélène Yapo-Etté, Bidyut Das, Corinne Abbadie, Sylviane Pied
Background Cerebral malaria (CM) is a fatal neuroinflammatory syndrome caused (in humans) by the protozoa Plasmodium (P.) falciparum. Glial cell activation is one of the mechanisms that contributes to neuroinflammation in CM. Result By studying a mouse model of CM (caused by P. berghei ANKA), we describe that the induction of autophagy promoted p21-dependent senescence in astrocytes and that CXCL-10
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Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-23 Edmund Keogh, Katelynn E. Boerner
The focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to:
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An immunological puzzle: The adaptive immune system fuels Alzheimer’s disease pathology Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-23 Lien Van Hoecke, Jonas Castelein, Junhua Xie, Lore Van Acker, Griet Van Imschoot, Elien Van Wonterghem, Ine Vlaeminck, Daan Verhaege, Wouter Claeys, Keimpe Wierda, Zsuzsanna Callaerts-Vegh, Roosmarijn E. Vandenbroucke
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by a concerning rise in prevalence. It is projected that the number of affected individuals will reach a staggering 150 million by 2050. While recent advancements in monoclonal antibodies targeting Aβ have shown some clinical effects, there is an urgent need for improved therapies to effectively address the impeding
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Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review Brain Behav. Immun. (IF 15.1) Pub Date : 2023-12-21 Jerome Henry Taylor, Julieta Bermudez-Gomez, Marina Zhou, Oscar Gómez, Casey Ganz-Leary, Cesar Palacios-Ordonez, Zeeshan M. Huque, Ran Barzilay, David R. Goldsmith, Raquel E. Gur
Objective While genetic and cohort studies suggest immune and reduction/oxidation (redox) alterations occur in psychosis, less is known about potential alterations in children and adolescents. Methods We conducted a systematic review to identify immune and redox biomarker studies in children and adolescents (mean age ≤ 18 years old) across the psychosis spectrum: from psychotic like experiences, which
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Stem-cell derived neurosphere assay highlights the effects of viral infection on human cortical development Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-22 Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Aberrant cortical development is a key feature of neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Both genetic and environmental risk factors are thought to contribute to defects in cortical development; however, model systems that can capture the dynamic process of human cortical development are not well established. To address this challenge, we combined recent progress
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Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-21 Timothy Matthews, Line Jee Hartmann Rasmussen, Antony Ambler, Andrea Danese, Jesper Eugen-Olsen, Daisy Fancourt, Helen L. Fisher, Kasper Karmark Iversen, Martin Schultz, Karen Sugden, Benjamin Williams, Avshalom Caspi, Terrie E. Moffitt
Social isolation and loneliness have been associated with poor health and increased risk for mortality, and inflammation might explain this link. We used data from the Danish TRIAGE Study of acutely admitted medical patients (N = 6,144, mean age 60 years), and from two population-representative birth cohorts: the New Zealand Dunedin Longitudinal Study (N = 881, age 45) and the UK Environmental Risk
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Internal circadian misallignment in a mouse model of chemotherapy induced fatigue Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-19 Yumeng Wang, Anouk W. van Beurden, Mayke M.H. Tersteeg, Stephan Michel, Anneke Kastelein, Jacques Neefjes, Jos H.T. Rohling, Johanna H. Meijer, Tom Deboer
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The psychological impact of COVID-19 pandemic and the role of good hygiene practices as protective factors: A commentary on the 2023 BBI impact award winner Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-20 Alessandra Borsini
Abstract not available
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Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-20 Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous system (CNS). They influence neuronal functions and circuit activities with effects on memory processes and behaviors. Here, we unravel a neuromodulatory activity of interleukin-15 (IL-15) in mouse brain. Acute exposure of hippocampal slices to IL-15 enhances gamma-aminobutyric acid (GABA) release and reduces
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An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB Brain Behav. Immun. (IF 15.1) Pub Date : 2023-11-20 Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z Shen, Shu Wan, Peng Shi
Pericyte is an indispensable cellular constituent of blood-brain barrier (BBB) and its homeostasis heavily rely on PDGFB-PDGFRβ signaling. However, the primary cellular sources of PDGFB in the central nervous system (CNS) are unclear. Microglia is not considered a component of BBB and its role in maintaining BBB integrity in steady state is controversial. In this study, by analyzing transcriptomic