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  • Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-04
    Deborah C. Koltai; Timothy W. Dunn; Patrick J. Smith; Drishti D. Sinha; Samuel Bobholz; Mark Kaddumukasa; Angelina Kakooza-Mwesige; Mayanja Kajumba; Caleigh E. Smith; Martin N. Kaddumukasa; Dirk E. Teuwen; Noeline Nakasujja; Payal Chrakraborty; Brad J. Kolls; Juliet Nakku; Michael M. Haglund; Anthony T. Fuller

    Objective Epilepsy is a global public health concern, with the majority of cases occurring in lower- and middle-income countries where the treatment gap remains formidable. In this study, we simultaneously explore how beliefs about epilepsy causation, perceived barriers to care, seizure disorder characteristics, and demographics influence the initial choice of healthcare for epilepsy and its impact

    更新日期:2020-08-04
  • Healthcare provider perspectives regarding epilepsy care in Uganda
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-03
    Deborah C. Koltai; Caleigh E. Smith; Grace Y. Cai; Olivia Ratliff; Angelina Kakooza-Mwesige; Josephine N. Najjuma; Rose Muhindo; Godfrey Z. Rukundo; Dirk E. Teuwen; Adrian Kayanja; Peter Kalubi; Michael M. Haglund; Anthony T. Fuller

    Objective Epilepsy is the most common chronic neurological disorder in the world and imposes a large economic burden on global healthcare systems, especially in low-income settings and rural areas as is found in sub-Saharan Africa (SSA). Despite the high epilepsy prevalence, there are no systematic descriptions of healthcare provider (HCP) perceptions and needs in managing people with epilepsy (PWE)

    更新日期:2020-08-04
  • Art and psychogenic nonepileptic seizures
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-03
    Lady Diana Ladino; Yamile Calle-López; Alexandra Carter; José Francisco Tellez-Zenteno

    Psychogenic nonepileptic seizures (PNES) are episodes of seizure-like symptoms that are not associated with epileptiform discharges on electroencephalogram (EEG). They can be remarkably difficult to distinguish from epileptic seizures: both may involve alterations in mental status and behavior, sensory or perceptual disturbances, as well as simple or complex motor patterns. Pictorial expressions of

    更新日期:2020-08-03
  • Epilepsy beliefs and misconceptions among patient and community samples in Uganda
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-03
    Mark Kaddumukasa; Patrick J. Smith; Martin N. Kaddumukasa; Mayanja Kajumba; Alysa Almojuela; Samuel Bobholz; Payal Chakraborty; Drishti D. Sinha; Noeline Nakasujja; Angelina Kakooza-Mwesige; Alex Gualtieri; Erica Onuoha; Juliet Nakku; Nadine Sanchez; Christine Muhumuza; Anthony T. Fuller; Michael M. Haglund; Deborah C. Koltai

    Objective The objective of the study was to characterize and compare the attitudes, beliefs, and perceptions about epilepsy across community and patient cohorts in Uganda. Methods This was a descriptive study utilizing two samples: a randomly selected, national survey community sample and a hospital-based patient sample of people with epilepsy (PWE) and their caregivers attending clinic settings in

    更新日期:2020-08-03
  • Stakeholder views of the practical and cultural barriers to epilepsy care in Uganda
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-03
    Nadine Sanchez; Mayanja Kajumba; Juma Kalyegira; Drishti D. Sinha; Samuel Bobholz; Alex Gualtieri; Payal Chakraborty; Erica Onuoha; Anthony T. Fuller; Dirk E. Teuwen; Michael M. Haglund; Deborah C. Koltai

    Objective Epilepsy is one of the most prevalent, treatable neurological diseases globally. In sub-Saharan Africa, people with epilepsy (PWE) frequently seek treatment from traditional or pastoral healers, who are more accessible than biomedical care providers. This often contributes to the substantial time delay in obtaining adequate biomedical care for these patients. In Uganda, the few biomedical

    更新日期:2020-08-03
  • Epilepsy by the numbers – From the US Centers for Disease Control and Prevention
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-02
    Rosemarie Kobau; Sanjeeb Sapkota; Page B. Pennell; Janet B. Croft

    This study used the most recent national data on epilepsy from the 2017 National Health Interview Survey (NHIS) to examine the distribution of types of provider visits in the last 12 months among 2.9 million adult respondents aged ≥ 18 years with active epilepsy (self-reported doctor-diagnosed epilepsy taking antiseizure medications and/or having ≥ 1 seizure in the past year) and compared these estimates

    更新日期:2020-08-02
  • Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-08-02
    Golnaz Zamanian; Maryam Shayan; Nastaran Rahimi; Taraneh Bahremand; Hamed Shafaroodi; Shahram Ejtemaei-Mehr; Iraj Aghaei; Ahmad Reza Dehpour

    N-methyl-d-aspartate receptor (NMDA-R)/nitric oxide (NO) pathway is involved in the intensification of the analgesic effect of opioids and the reduction of the intensity of opioids tolerance and dependence. In the current study, we investigated the involvement of NMDA-R/NO pathway in chronic morphine-treated mice in both the development of tolerance to the analgesic effect of morphine and in pentylenetetrazole

    更新日期:2020-08-02
  • Trait impulsivity correlates with active myoclonic seizures in genetic generalized epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-31
    Marte Syvertsen; Jeanette Koht; Kaja Selmer; Ulla Enger; Deb K. Pal; Anna Smith

    Background Juvenile myoclonic epilepsy (JME) is a common subtype of genetic generalized epilepsy (GGE) arising in adolescence and is often associated with executive function (EF) deficits. Some EF components like response inhibition have been extensively evaluated in JME, but few studies have focused upon trait impulsivity or compared between GGE subtypes. The aim of the present study was to compare

    更新日期:2020-07-31
  • Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-31
    Rodolphe Nenert; Jane B. Allendorfer; E. Martina Bebin; Tyler E. Gaston; Leslie E. Grayson; James T. Houston; Jerzy P. Szaflarski

    Objective Resting-state (rs) network dysfunction is a contributing factor to treatment resistance in epilepsy. In treatment-resistant epilepsy (TRE), pharmacological and nonpharmacological therapies have been shown to improve such dysfunction. In this study, our goal was to prospectively evaluate the effect of highly purified plant-derived cannabidiol (CBD; Epidiolex®) on rs functional magnetic resonance

    更新日期:2020-07-31
  • A European questionnaire survey on epilepsy monitoring units' current practice for postoperative psychogenic nonepileptic seizures' detection
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-31
    Sofia Markoula; Andreas Liampas; Guido Rubolli; John Duncan; Demetrios Velis; Andreas Schulze-Bonhage; Guekht Alla; Karen Bartholomeyczik; Janede Tisi; Adrien Gras; Morten Ingvar Lossius; Villani Flavio Silvano; Staack Anke Maren; Annette Hospes; Johannes C. Baaijen; Elisabeth C.W. van Straaten; Hanneke E. Ronner; Sara Casciato; Philippe Ryvlin

    Background In cases undergoing epilepsy surgery, postoperative psychogenic nonepileptic seizures (PNES) may be underdiagnosed complicating the assessment of postsurgical seizures' outcome and the clinical management. We conducted a survey to investigate the current practices in the European epilepsy monitoring units (EMUs) and the data that EMUs could provide to retrospectively detect cases with postoperative

    更新日期:2020-07-31
  • Seizure as the presenting symptom of COVID-19: A retrospective case series
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-21
    Pria Anand; Abrar Al-Faraj; Elie Sader; Jonathan Dashkoff; Myriam Abdennadher; Rubachandran Murugesan; Anna M. Cervantes-Arslanian; Ali Daneshmand

    Background Coronavirus Disease 2019 (COVID-19) has rapidly become a global pandemic, with over 1.8 million confirmed cases worldwide to date. Preliminary reports suggest that the disease may present in diverse ways, including with neurological symptoms, but few published reports in the literature describe seizures in patients with COVID-19. Objective The objective of the study was to characterize the

    更新日期:2020-07-30
  • The management of epilepsy in clinical practice: Do the timing and severity of the disease influence the priorities of patients and the caring physicians? Data from the EPINEEDS study
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-29
    Gabriele Enia; Giorgia Giussani; Elisa Bianchi; Oriano Mecarelli; Ettore Beghi

    Objective The objective of this study was to assess the priorities of patients with epilepsy and their caring physicians with reference to the timing and severity of the disease. Methods This is a national survey in which patients with epilepsy followed in 21 Italian epilepsy centers, and their caring physicians were asked to fill anonymous questionnaires to collect data on different aspects of the

    更新日期:2020-07-30
  • The importance of mental health in improving quality of life in transition-aged patients with epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-25
    Sarah A. Healy; Tadeu A. Fantaneanu; Sharon Whiting

    Objective Adolescents with epilepsy are known to have a lower quality of life (QoL) than the typically developing adolescent population. In order to address this, treating physicians have primarily focused on obtaining seizure control. However, growing evidence suggests a strong relation between QoL and mental health in adults with epilepsy and other chronic conditions. Given the high rate of mental

    更新日期:2020-07-25
  • Validity of the Personal Impact of Epilepsy Scale (PIES) in patients with epilepsy in Uganda
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-25
    Payal Chakraborty; Joao Ricardo Nickenig Vissoci; Christine Muhumuza; Anthony T. Fuller; Deborah C. Koltai; Sylvia Nshemerirwe; Michael M. Haglund; Martin N. Kaddumukasa

    Purpose We sought to address the construct validity and reliability of the Personal Impact of Epilepsy Scale (PIES), an epilepsy-specific quality-of-life measure, in patients with epilepsy in Uganda. We also sought to assess the applicability of the scale across three languages: English, Luganda, and Runyankole. Methods Patients with epilepsy (N = 626) were recruited at the time of care seeking from

    更新日期:2020-07-25
  • Epilepsy and school in the Middle East and North Africa (MENA) region: The current situation, challenges, and solutions
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-24
    Najib Kissani; Khaoula Balili; Boulenouar Mesraoua; Fatema Abdulla; Ghaieb Bashar; Raidah Al-Baradie; Rabha Elsahli; Eetedal Ibrahim; Abdullah Al-Asmi; Nesma Mounir; Nirmeen Adel Kishk; Amina Harharah; Ahmed Abu Aliqa; Arlette Honein; Maher Arabi; Ali Akbar Asadi-Pooya

    Education is a human right that plays a key role in social and economic development. Children having active epilepsy may not be properly schooled in ordinary school structures. Students with epilepsy (SWE) are often faced with academic barriers. The lack of information about the current status of special education for SWE obliged the researchers to try to describe the existing reality of the special

    更新日期:2020-07-24
  • The effect of COVID-19 pandemic on seizure control and self-reported stress on patient with epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-14
    Amal Alkhotani; Muhammad I. Siddiqui; Fahad Almuntashri; Renad Baothman

    Objectives The objective of the study was to assess if patients with epilepsy (PWE) experienced an increase in seizure frequency and self-reported stress during the COVID-19 pandemic. Methods This is a cross-sectional study conducted in Saudi Arabia in April 2020. An electronic self-administered questionnaire was distributed to PWE via their treating neurologist. The variables included were demographic

    更新日期:2020-07-24
  • RNS modifications to eliminate stimulation-triggered signs or symptoms (STS): Case series and practical guide
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-24
    Alison M. Hixon; Mesha-Gay Brown; Danielle McDermott; Samuel Destefano; Aviva Abosch; Lora Kahn; Steven Ojemann; Cornelia Drees
    更新日期:2020-07-24
  • Real-world hospitalization risk in patients with epilepsy treated with perampanel
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-23
    Xuan Li; Feride Frech; Craig A. Plauschinat; Mugdha Gore

    Aim The aim of this study was to evaluate the risk of hospitalization and emergency department admission following initiation of perampanel treatment in patients with epilepsy. Methods This study is a retrospective longitudinal cohort study (Optum® Clinformatics® Datamart). Patients 4 to 11 years of age with a diagnosis of partial onset seizures or ≥ 12 years of age with primary generalized tonic–clonic

    更新日期:2020-07-24
  • West syndrome: A study of 26 patients receiving short-term therapy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-18
    Sebastián Fortini; Gabriela Reyes Valenzuela; Lorena Fasulo; Roberto Caraballo

    Objective We describe the electroclinical characteristics of a series of 26 patients with idiopathic West syndrome (WS), who had an excellent response to treatment with vigabatrin (VGB) and corticosteroids alone or in combination. Methods Evaluating the records of 178 patients with WS studied at Garrahan Hospital, Niño Jesús Hospital, and Clínica San Lucas between January 2005 and June 2017, we selected

    更新日期:2020-07-24
  • How soon should urgent EEG be performed following a first epileptic seizure?
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-18
    A. Llauradó; E. Santamarina; E. Fonseca; M. Olivé; M. Requena; M. Sueiras; L. Guzmán; A. Ballvé; D. Campos; I. Seijó; L. Abraira; M. Quintana; M. Toledo

    Purpose Patients with a first unprovoked epileptic seizure are often seen in emergency services. Electroencephalography (EEG) is indicated for diagnosing epilepsy, but the optimal time to perform this test has not been defined. This study aimed to determine the time interval following a seizure within which EEG has the greatest diagnostic yield. Methods We conducted a retrospective study of all adult

    更新日期:2020-07-24
  • Gender differences in Epworth Sleepiness Scale revealed by paired patient–spouse scoring
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-08
    Andreja Packard; Ramon Bautista; Carmen Smotherman; Shiva Gautham

    Purpose Evaluation of daytime sleepiness in the clinical sleep practice is commonly performed by administering the Epworth Sleepiness Scale (ESS). Our study investigates gender differences of ESS responses in patients (PTs) with a primary complaint of nighttime sleep disruption as they relate to ESS responses obtained from PTs' spouses (Ss). Methods One hundred and sixty-four patient–spouse (PT-S)

    更新日期:2020-07-24
  • Long-term employment, education, and healthcare costs of childhood and adolescent onset of epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-07-01
    Poul Jennum; Nanette Marinette Monique Debes; Rikke Ibsen; Jakob Kjellberg

    Objective Childhood- and adolescent-onset epilepsy may have a significant impact on long-term educational and vocational status, which in turn has consequences for individuals' socioeconomic status. We estimated the factual long-term socioeconomic consequences and healthcare costs of individuals with diagnosed epilepsy. Methods The prospective cohort study included Danish individuals with epilepsy

    更新日期:2020-07-24
  • Effect of Mozart K.448 on interictal epileptiform discharges in children with epilepsy: A randomized controlled pilot study
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-06-11
    Tanitnun Paprad; Montida Veeravigrom; Tayard Desudchit

    Background Epilepsy is a common pediatric neurologic disease in Thailand. However, the mainstay antiepileptic pharmacotherapies can induce severe side effects. While the benefit of playing Mozart K.448 music has been studied as an alternative, supplementary, nonpharmacologic treatment for epilepsy, the literature features limited few randomized controlled trial studies of children. Objective We aimed

    更新日期:2020-07-24
  • Epilepsy and chronic obstructive pulmonary disease among U.S. adults: National Health Interview Survey 2013, 2015, and 2017
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-06-09
    Niu Tian; Matthew Zack; Anne G. Wheaton; Kurt J. Greenlund; Janet B. Croft

    Background Among U.S. adults, over 4 million report a history of epilepsy, and more than 15 million report a history of chronic obstructive pulmonary disease (COPD); Chronic obstructive pulmonary disease, which includes chronic bronchitis and emphysema, is a common somatic comorbidity of epilepsy. This study assessed the relationship between self-reported physician-diagnosed epilepsy and COPD in a

    更新日期:2020-07-24
  • Psychogenic nonepileptic seizures in Latin America: A survey describing current practices
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-06-02
    Lady Diana Ladino; Vanessa Benjumea-Cuartas; Yamile Calle-López; Juan Pablo Orozco-Hernández; Diana Marcela Castrillón-Velilla; Reydmar López-González; Anilu Daza-Restrepo; Mario Alberto Genel Castillo; Markus Reuber; Alyssa Denton; José F. Tellez-Zenteno

    Objective Psychogenic nonepileptic seizures (PNES) are one of the most common differential diagnoses of epilepsy. This study provides an overview of diagnostic and treatment services for patients with PNES across Latin America. Methods In 2017–2018, clinicians practicing in Latin America with responsibilities for patients with PNES were contacted to respond to a survey regarding the management of this

    更新日期:2020-07-24
  • Socioeconomic disparities in patients with psychogenic nonepileptic seizures and their caregivers
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-06-01
    Diane L. Teagarden; Matthew L. Morton; Nicholas J. Janocko; Olivia Groover; Hannah K. Villarreal; Latasha Evans; Daniel L. Drane; Ioannis Karakis

    Objective There is no information on disparities of patients with psychogenic nonepileptic seizures (PNES) and their caregivers. The objective of this exploratory study is to compare patients with PNES and caregivers with low socioeconomic status (SES) with those of high SES for disparities in healthcare use, seizures, medication adverse effects, psychosocial impact, and knowledge about epilepsy. Methods

    更新日期:2020-07-24
  • Validation of the predictive model for seizure recurrence after withdrawal of antiepileptic drugs
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-05-19
    Shan-shan Chu; Ge Tan; Xue-ping Wang; Ling Liu

    Purpose The purpose of this study was to validate the practicability of Lamberink's prediction model in risk assessment of antiepileptic drug (AED) withdrawal in a real, seizure-free population and to find a practical cutoff value to guide clinical withdrawal. Methods A group of seizure-free patients from West China Hospital was recruited. Each patient had been seizure-free for at least two years.

    更新日期:2020-07-24
  • Biomarkers for posttraumatic epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-04-18
    Asla Pitkänen; Tomi Paananen; Jenni Kyyriäinen; Shalini Das Gupta; Mette Heiskanen; Niina Vuokila; Ivette Bañuelos-Cabrera; Niina Lapinlampi; Natallie Kajevu; Pedro Andrade; Robert Ciszek; Leonardo Lara-Valderrábano; Xavier Ekolle Ndode-Ekane; Noora Puhakka

    A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecular, histologic, radiographic, or physiologic characteristics. To improve the understanding and use of biomarker terminology in biomedical research, clinical

    更新日期:2020-04-18
  • GABAergic interneurons in epilepsy: More than a simple change in inhibition
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-02-05
    Joseane Righes Marafiga; Mayara Vendramin Pasquetti; Maria Elisa Calcagnotto

    The pathophysiology of epilepsy has been historically grounded on hyperexcitability attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the brain. The decreased inhibition is mostly attributed to deficits in gamma-aminobutyric acid-containing (GABAergic) interneurons, the main source of inhibition in the central nervous system. However, the cell diversity, the wide

    更新日期:2020-02-05
  • The cerebellum and epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2020-02-05
    Martha L. Streng; Esther Krook-Magnuson

    Epilepsy is the fourth most common neurological disorder, but current treatment options provide limited efficacy and carry the potential for problematic adverse effects. There is an immense need to develop new therapeutic interventions in epilepsy, and targeting areas outside the seizure focus for neuromodulation has shown therapeutic value. While not traditionally associated with epilepsy, anatomical

    更新日期:2020-02-05
  • Glia and extracellular matrix molecules: What are their importance for the electrographic and MRI changes in the epileptogenic zone?
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-26
    Joao Pereira Leite; Jose Eduardo Peixoto-Santos

    Glial cells and extracellular matrix (ECM) molecules are crucial for the maintenance of brain homeostasis. Especially because of their actions regarding neurotransmitter and ionic control, and synaptic function, these cells can potentially contribute to the hyperexcitability seen in the epileptogenic, while ECM changes are linked to synaptic reorganization. The present review will explore glial and

    更新日期:2019-12-26
  • Amygdaloid complex anatomopathological findings in animal models of status epilepticus
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-19
    Cristiane Queixa Tilelli; Larissa Ribeiro Flôres; Vinicius Rosa Cota; Olagide Wagner de Castro; Norberto Garcia-Cairasco
    更新日期:2019-12-19
  • Conductance-based models and the fragmentation problem: A case study based on hippocampal CA1 pyramidal cell models and epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-19
    Julian Tejada; Antonio C. Roque

    Epilepsy has been a central topic in computational neuroscience, and in silico models have shown to be excellent tools to integrate and evaluate findings from animal and clinical settings. Among the different languages and tools for computational modeling development, NEURON stands out as one of the most used and mature neurosimulators. However, despite the vast quantity of models developed with NEURON

    更新日期:2019-12-19
  • Epilepsy as a dynamical system, a most needed paradigm shift in epileptology
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-16
    Márcio Flávio Dutra Moraes; Daniel de Castro Medeiros; Flávio Afonso Gonçalves Mourao; Sergio Augusto Vieira Cancado; Vinicius Rosa Cota

    The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has guided pharmacological treatment since the early twentieth century. Although tackling epilepsy's seizure-prone feature, by tonically modifying overall circuit excitability and/or connectivity, the last 50 years of drug development has not seen a substantial improvement in seizure suppression of refractory

    更新日期:2019-12-16
  • Exploiting cannabinoid and vanilloid mechanisms for epilepsy treatment
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-12
    Laila Asth; Lia P. Iglesias; Antônio C. De Oliveira; Marcio F.D. Moraes; Fabrício A. Moreira

    This review focuses on the possible roles of phytocannabinoids, synthetic cannabinoids, endocannabinoids, and “transient receptor potential cation channel, subfamily V, member 1” (TRPV1) channel blockers in epilepsy treatment. The phytocannabinoids are compounds produced by the herb Cannabis sativa, from which Δ9-tetrahydrocannabinol (Δ9-THC) is the main active compound. The therapeutic applications

    更新日期:2019-12-12
  • The role of interictal discharges in ictogenesis — A dynamical perspective
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-12-02
    Jan Chvojka; Jan Kudlacek; Wei-Chih Chang; Ondrej Novak; Filip Tomaska; Jakub Otahal; John G.R. Jefferys; Premysl Jiruska

    Interictal epileptiform discharge (IED) is a traditional hallmark of epileptic tissue that is generated by the synchronous activity of a population of neurons. Interictal epileptiform discharges represent a heterogeneous group of pathological activities that differ in shape, duration, spatiotemporal distribution, underlying cellular and network mechanisms, and their relationship to seizure genesis

    更新日期:2019-12-02
  • Life and death in the hippocampus: What's bad?
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-20
    Victor Rodrigues Santos; Igor santana Melo; Amanda Larissa Dias Pacheco; Olagide Wagner de Castro

    The hippocampal formation is crucial for the generation and regulation of several brain functions, including memory and learning processes; however, it is vulnerable to neurological disorders, such as epilepsy. Temporal lobe epilepsy (TLE), the most common type of epilepsy, changes the hippocampal circuitry and excitability, under the contribution of both neuronal degeneration and abnormal neurogenesis

    更新日期:2019-11-20
  • Renaissance natural philosophy, brain, and epilepsy (and some ideas about science)
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-16
    Eduardo Henrique Peiruque Kickhöfel

    Renaissance was a period full of religious and supernatural concepts and practices distant from the contemporary scientific world. Some erratic behaviors were considered demonic possessions and treated by exorcisms. It is supported by many sources. However, some important sources of the Renaissance point to a different picture. They show trends towards naturalistic explanations of many diseases, including

    更新日期:2019-11-16
  • Hijacking of hippocampal–cortical oscillatory coupling during sleep in temporal lobe epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-15
    Renan Augusto Viana Mendes; Leonardo Rakauskas Zacharias; Rafael Naime Ruggiero; João Pereira Leite; Márcio Flavio Dutra Moraes; Cleiton Lopes-Aguiar

    Memory impairment is the most common cognitive deficit in patients with temporal lobe epilepsy (TLE). This type of epilepsy is currently regarded as a network disease because of its brain-wide alterations in functional connectivity between temporal and extra-temporal regions. In patients with TLE, network dysfunctions can be observed during ictal states, but are also described interictally during rest

    更新日期:2019-11-15
  • Clinicians embracing social media: Potential and pitfalls
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-12
    Mustafa Sultan; Elen M. Brown; Rhys H. Thomas

    The bedrock of clinical medicine is effective communication. A generation ago, this was primarily the clinical consultation, the letter to the general practitioner, and the occasional scientific paper. In 2019, the avenues and opportunities for communication have exploded and include a pantheon of new and social media. We review the current state of how doctors use social media, and what can be gained

    更新日期:2019-11-12
  • The role of P-glycoprotein (P-gp) and inwardly rectifying potassium (Kir) channels in sudden unexpected death in epilepsy (SUDEP)
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-06
    Jerónimo Auzmendi; Enes Akyuz; Alberto Lazarowski

    Sudden unexpected death in epilepsy (SUDEP) is the major cause of death that affects patients with epilepsy. The risk of SUDEP increases according to the frequency and severity of uncontrolled seizures; therefore, SUDEP risk is higher in patients with refractory epilepsy (RE), in whom most antiepileptic drugs (AEDs) are ineffective for both seizure control and SUDEP prevention. Consequently, RE and

    更新日期:2019-11-06
  • Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-05
    Vinícius Rosa Cota; Jasiara Carla de Oliveira; Laila Cristina Moreira Damázio; Márcio Flávio Dutra Moraes

    Electrical stimulation of the central nervous system is a promising alternative for the treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is most usually carried out as continuous trains of current or voltage pulses fired at rates of 100 Hz or above, since lower frequencies yield controversial results. On the other hand, stimulation frequency should be as low

    更新日期:2019-11-05
  • Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-05
    Daniela M.S. Moura; Igor R.P. de Sales; Juliana A. Brandão; Marcos R. Costa; Claudio M. Queiroz

    In rodents, status epilepticus (SE) triggered by chemoconvulsants can differently affect the proliferation and fate of adult-born dentate granule cells (DGCs). It is unknown whether abnormal neurogenesis results from intracellular signaling associated with drug-receptor interaction, paroxysmal activity, or both. To test the contribution of these factors, we systematically compared the effects of kainic

    更新日期:2019-11-05
  • Molecular tools for the characterization of seizure susceptibility in genetic rodent models of epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-11-01
    José Ramón Bosque; Ricardo Gómez-Nieto; Sebastián Hormigo; M.Javier Herrero-Turrión; Elena Díaz-Casado; Consuelo Sancho; Dolores E. López

    Epilepsy is a chronic neurological disorder characterized by abnormal neuronal activity that arises from imbalances between excitatory and inhibitory synapses, which are highly correlated to functional and structural changes in specific brain regions. The difference between the normal and the epileptic brain may harbor genetic alterations, gene expression changes, and/or protein alterations in the

    更新日期:2019-11-01
  • Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-10-29
    Shannon Clarke; Philippa J. Karoly; Ewan Nurse; Udaya Seneviratne; Janelle Taylor; Rory Knight-Sadler; Robert Kerr; Braden Moore; Patrick Hennessy; Dulini Mendis; Claire Lim; Jake Miles; Mark Cook; Dean R. Freestone; Wendyl D'Souza

    Epilepsy diagnosis can be costly, time-consuming, and not uncommonly inaccurate. The reference standard diagnostic monitoring is continuous video-electroencephalography (EEG) monitoring, ideally capturing all events or concordant interictal discharges. Automating EEG data review would save time and resources, thus enabling more people to receive reference standard monitoring and also potentially heralding

    更新日期:2019-10-29
  • Patterns of default mode network in temporal lobe epilepsy with and without hippocampal sclerosis
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-10-20
    Tamires Araujo Zanão; Tatila Martins Lopes; Brunno Machado de Campos; Clarissa Lin Yasuda; Fernando Cendes

    The default mode network (DMN) consists of the deactivation of specific regions during the performance of cognitive tasks and activation during resting or mind wandering. Several pieces of evidence indicate the impairment of DMN in patients with mesial temporal lobe epilepsy (MTLE). However, most of these studies combined different underlying etiologies, failing to disentangle the influence of seizures

    更新日期:2019-10-20
  • Promise of extracellular vesicles for diagnosis and treatment of epilepsy
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-10-18
    Dinesh Upadhya; Ashok K. Shetty

    Extracellular vesicles (EVs) released from cells play vital roles in intercellular communication. Moreover, EVs released from stem cells have therapeutic properties. This review confers the potential of brain-derived EVs in the cerebrospinal fluid (CSF) and the serum as sources of epilepsy-related biomarkers, and the promise of mesenchymal stem cell (MSC)-derived EVs for easing status epilepticus (SE)-induced

    更新日期:2019-10-18
  • Gene networks and microRNAs: Promises and challenges for treating epilepsies and their comorbidities
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-09-04
    Francesca Lovisari; Michele Simonato

    Neurobiology research has used an essentially reductionist approach for many years, dissecting out the brain in more simple elements. Recent technical advances, like systems biology, have made now possible to embrace a more holistic vision and try to tackle the complexity of the system. In this short review, we describe how these approaches, in particular analyses or gene networks and of microRNAs

    更新日期:2019-09-04
  • New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-08-13
    Andrea Verónica Enrique; Mauricio Emiliano Di Ianni; Sofía Goicoechea; Alberto Lazarowski; María Guadalupe Valle-Dorado; Juan José López Costa; Luisa Rocha; Elena Girardi; Alan Talevi

    Despite the approval of a considerable number of last generation antiepileptic drugs (AEDs) (only in the last decade, six drugs have gained Food and Drug Administration approval), the global figures of seizure control have seemingly not improved, and available AED can still be regarded as symptomatic treatments. Fresh thinking in AEDs drug discovery, including the development of drugs with novel mechanisms

    更新日期:2019-08-13
  • New avenues in molecular genetics for the diagnosis and application of therapeutics to the epilepsies
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-08-07
    Pedro H.M. Magalhães; Helena T. Moraes; Maria C.P. Athie; Rodrigo Secolin; Iscia Lopes-Cendes

    Genetic epidemiology studies have shown that most epilepsies involve some genetic cause. In addition, twin studies have helped strengthen the hypothesis that in most patients with epilepsy, a complex inheritance is involved. More recently, with the development of high-density single-nucleotide polymorphism (SNP) microarrays and next-generation sequencing (NGS) technologies, the discovery of genes related

    更新日期:2019-08-07
  • Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-08-06
    Anthony Marincovich; Eduardo Bravo; Brian Dlouhy; George B. Richerson

    Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with refractory epilepsy. Human studies and animal models suggest that respiratory arrest is the initiating event leading to death in many cases of SUDEP. It has previously been reported that the onset of apnea can coincide with the spread of seizures to the amygdala, and apnea can be reproduced by electrical

    更新日期:2019-08-06
  • Drug-resistant epilepsy: From multiple hypotheses to an integral explanation using preclinical resources
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-08-02
    Daniel Pérez-Pérez; Christian L. Frías-Soria; Luisa Rocha

    Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. The pharmacoresistant condition in epilepsy is mainly explained by six hypotheses. In addition, several experimental models have been used to understand the mechanisms involved in pharmacoresistant epilepsy and to identify novel therapies to control this condition. However, the global prevalence of this disease persists

    更新日期:2019-08-02
  • Epilepsy under the scope of ultra-high field MRI
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-07-10
    Carlo Rondinoni; Celso Magnun; Alexandre Vallota da Silva; Helmut Manfred Heinsen; Edson Amaro

    Ultra-high field magnetic resonance imaging (UHF-MRI) is capable of unraveling anatomical structures in a submillimeter range. In addition, its high resonance regime allows the quantification of constitutive molecules in a spatially sensitive manner, a crucial capability for determining the extent and localization of a probable epileptogenic region or the severity of the epilepsy. The main technical

    更新日期:2019-07-10
  • Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-06-07
    Rafael Guimarães dos Santos; Jaime Eduardo Cecilio Hallak

    Ayahuasca is a botanical hallucinogenic preparation traditionally used for ritual and therapeutic purposes by native populations of the Northwestern Amazon. In the last decades, ayahuasca use has spread to Europe, the United States, Asia, and Africa, and interest in the possible therapeutic uses of ayahuasca for treating anxiety and mood disorder and substance-use disorders has increased both among

    更新日期:2019-06-07
  • The epileptic experience in the works of Dostoyevsky and Machado de Assis
    Epilepsy Behav. (IF 2.508) Pub Date : 2019-04-09
    Peter Wolf; Elza Márcia Yacubian

    Towards the end of the 19th century, two writers who are considered the uppermost representatives of their respective national literatures, Dostoyevsky of Russia and Machado de Assis of Brazil had epilepsy, probably both temporal lobe epilepsy, but their attitudes were opposite. Dostoyevsky was as open about his diagnosis as Machado was secretive, but both included seizure experiences in their works

    更新日期:2019-04-09
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