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Public misconceptions and attitudes towards persons diagnosed with epilepsy in the Kingdom of Bahrain: A cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-07 Alaa Elmazny, Mohammed Ahmed A. Alkharisi, Yazed Saad J. Ibrahim, Atheer Baalqasim A. Albarakati, Shatha Shayan Almutairi, Lina Abdulrahim Altalhi, Enas Mostafa Darwish, Rehab Magdy, Eman Hany Elsebaie, Ahmed Dahshan
Despite significant advancements in the understanding and treatment of epilepsy, the quality of life for persons diagnosed with Epilepsy (PdwE) can still be negatively impacted due to prevalent misconceptions and societal attitudes. This study aimed to investigate the knowledge, misconceptions, and attitudes towards epilepsy in Bahrain. This cross-sectional study involved 1079 participants aged ≥ 18 years
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Longitudinal point-of-care assessment of psychomotor vigilance in children in the epilepsy monitoring unit Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-07 Karim Mithani, Simeon M. Wong, Hrishikesh Suresh, Ivanna Yau, Elizabeth N. Kerr, Mary Lou Smith, Elizabeth Donner, George M. Ibrahim
The epilepsy monitoring unit (EMU) is a complex and dynamic operational environment, where the cognitive and behavioural consequences of medical and environmental changes often go unnoticed. The psychomotor vigilance task (PVT) has been used to detect changes in cognition and behaviour in numerous contexts, including among astronauts on spaceflight missions, pilots, and commercial drivers. Here, we
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Neuropsychological Rehabilitation for Epilepsy in India: Looking Beyond the Basics Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-06 Shivani Sharma, Ashima Nehra, Shivam Pandey, Madhavi Tripathi, Achal Srivastava, M.V. Padma, Ajay Garg, R.M. Pandey, Sarat Chandra, Manjari Tripathi
Neuropsychological Rehabilitation (NR) helps manage cognitive deficits in epilepsy. As internationally developed programs have limited applicability to resource-limited countries, we developed a program to bridge this gap. This 6-week caregiver-assisted, culturally suitable program has components of (1) psychoeducation, (2) compensatory training, and, (3) cognitive retraining and is called EMPOWER
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Characteristics and outcomes of youth with functional seizures attending intensive interdisciplinary pain treatment Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-06 Jennifer A. Scheurich, Kelsey M. Klaas, Leslie A. Sim, Karen E. Weiss, Hannah F. Case, Cynthia Harbeck-Weber
Functional seizures (FS) can be debilitating and negatively impact quality of life. Yet intervention research for FS is limited, especially for youth. This study examined clinical characteristics and outcomes of youth with FS (13–23 years) presenting to a pediatric intensive interdisciplinary pain treatment (IIPT) program in the midwestern United States. Sixty youth (mean age = 16.5 years; 83.3 % female)
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Effect of duration of sodium valproate therapy on bone mineral density and vitamin D levels Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-05 Dinesh Nirmal, Samee Abdul, Poornima Jaiswal, S. Naunihal Singh, Amit Avaragollapuravarga Mathada, Preeti Nagaraj
This study aimed to evaluate the impact of prolonged sodium valproate use on bone mineral density (BMD) and Vitamin D levels in pediatric epilepsy patients. In a cross-sectional study conducted at the Epilepsy Clinic of Niloufer Hospital, Hyderabad, India, 50 pediatric patients (aged 4–10 years) were recruited. The cohort comprised 30 epilepsy patients on sodium valproate treatment (cases) and 20 healthy
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Pregnancy, antiseizure medications and unexplained intrauterine foetal death Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-04 Frank J.E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison E. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie
To assess the role of antiseizure medication (ASM) regimens and other factors in relation to the occurrence of intrauterine foetal death (IUFD) in pregnant women with epilepsy (WWE) enrolled in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs (APR). IUFDs occurred in 70 (3.01 %) of 2,323 prospective pregnancies from WWE with known outcomes in the APR. Factors associated with
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The role of stand-alone videos in the diagnosis of seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-01 Ushtar Amin, Selim R. Benbadis
The diagnosis of seizures and seizure mimics relies primarily on the history, but history has well-known limitations. Video recordings of events are a powerful extension of the history because they allow neurologists to view the events in question. In addition, they are readily available in situation, whereas the gold standard of EEG-video is not. That includes underserved or rural areas, and events
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Patient experiences of resection versus responsive neurostimulation for drug-resistant epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-01 Tobias Haeusermann, Emily Yang Liu, Kristina Celeste Fong, Daniel Dohan, Winston Chiong
This study explored illness experiences and decision-making among patients with epilepsy who underwent two different types of surgical interventions: resection versus implantation of the NeuroPace Responsive Neurostimulation System (RNS). We recruited 31 participants from a level four epilepsy center in an academic medical institution. We observed 22 patient clinic visits (resection: n = 10, RNS: n
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Tuberous sclerosis complex in adulthood: focus on epilepsy prognosis Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Laura Licchetta, Giulia Bruschi, Carlotta Stipa, Laura Maria Beatrice Belotti, Lorenzo Ferri, Barbara Mostacci, Luca Vignatelli, Raffaella Minardi, Lidia Di Vito, Lorenzo Muccioli, Antonella Boni, Paolo Tinuper, Francesca Bisulli
Typically diagnosed in early childhood or adolescence, TSC is a chronic, multisystemic disorder with age-dependent manifestations posing a challenge for transition and for specific surveillance throughout the lifetime. Data on the clinical features and severity of TSC in adults and on the prognosis of epilepsy are scarce. We analyzed the clinical and genetic features of a cohort of adult patients with
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Translation and validation of the Vietnamese Epilepsy Self-Management Scale (V-ESMS) Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Minh-An Thuy Le, Truong Thuong Nguyen, Tuan Le Van
This study aimed to translate and validate the Vietnamese version of the Epilepsy Self-Management Scale (V-ESMS). The translation and cross-cultural adaptation of the original version of the ESMS into Vietnamese followed the Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes Measures guideline with “forward–backward” translation and culturally
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Antiseizure medication withdrawal in adult patients with idiopathic generalized epilepsy: Performance of two seizure recurrence prediction models Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Sofía Lallana, Elena Fonseca, Manuel Quintana, Laura Abraira, Daniel Campos-Fernández, Samuel López-Maza, Estevo Santamarina, Manuel Toledo, Javier Salas-Puig
Currently, there is a limited availability of tools to predict seizure recurrence after discontinuation of antiseizure medications (ASMs). This study aimed to establish the seizure recurrence rate following ASM cessation in adult patients with idiopathic generalized epilepsy (IGE) and to assess the predictive performance of the Lamberink and the Stevelink prediction models using real-world data. Retrospective
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Long-term memory consolidation of new words in children with self-limited epilepsy with centro-temporal spikes Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 C. Mayor, C. Moser, C. Korff
Accelerated long-term forgetting has been studied and demonstrated in adults with epilepsy. In contrast, the question of long-term consolidation (delays > 1 day) in children with epilepsy shows conflicting results. However, childhood is a period of life in which the encoding and long-term storage of new words is essential for the development of knowledge and learning. The aim of this study was therefore
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Epilepsy and education: A case-control analysis of the impact of an intensive epilepsy training program on undergraduate medical students Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Roberto Diaz-Peregrino, Daniel San-Juan, Aleida Arritola-Uriarte, Álvaro Contreras-Salazar, Jesús del Moral-Bastida, Raúl Miranda-Ojeda
To evaluate the knowledge, attitudes, and practical skills of students submitted to a 6-week intensive training in epilepsy compared to students without any training but mandatory neurology classes. It is a case-control study. After completing a 6-week intensive Academic, Clinical, and Research Program in epilepsy, TUMSs answered a validated Knowledge Attitudes and Practices (KAP) questionnaire. The
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Comprehensive review of status gelasticus: Diagnostic challenges and therapeutic insights Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Antonio Gennaro Nicotera, Giulia Spoto, Greta Amore, Ambra Butera, Gabriella Di Rosa
Status gelasticus is a rare form of status epilepticus characterized by prolonged and/or clustered gelastic seizures. The review encompasses an analysis of cases reported in the literature, focusing on causes, clinical-electroencephalographic features, and therapeutic interventions. The study reveals the challenges in defining and understanding status gelasticus due to its diverse etiologies and limited
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Socioeconomic status in adulthood of children with and without a history of seizures: A retrospective cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-29 Paolo P. Mazzone, Christopher J. Weir, Jacqueline Stephen, Sohinee Bhattacharya, Richard F.M. Chin
Compare adulthood socioeconomic status for children with and without a history of seizures. Retrospective cohort study using Aberdeen Children of the Nineteen Fifties (ACONF) data comprising children born 1950–1956 attending primary school 1962–1964, with follow-up data collected in 2001. Adulthood socioeconomic status was based on registrar general measure of occupational social class and categorised
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Experiences of using the MINDSET Self-Management mobile health app among Hispanic Patients:Results of a qualitative study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-26 Refugio Sepulveda, Jenny Chong, Ross Shegog, Kimberly Martin, Charles Begley, Robert Addy, Omar Rosales, Tomas Nuño, Shiela Soto, Cecilia Rosales, David Labiner
Interventions focusing on epilepsy self-management (ESM) are vital for promoting the health of people living with epilepsy. E-technology and mobile health (mHealth) tools are becoming increasingly integrated into practice to promote self-management strategies for chronic diseases, enhance care delivery, and reduce health disparities. Management Information and Decision Support Epilepsy Tool (MINDSET)
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First epileptic seizure and quality of life – A prospective study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-24 Louise Linka, Selina Nephuth, Iris Gorny, Kristina Krause, Peter Michael Mross, Panagiota-Eleni Tsalouchidou, Felix Zahnert, Sven Fuest, Katja Menzler, Susanne Knake, Lena Habermehl
Impaired QoL and depression are common in patients with chronic epilepsies; however, data on the impact of a first seizure on QoL are sparse. According to the current ILAE-definition of epilepsy, patients may be diagnosed with epilepsy immediately after the first seizure, if EEG and/or imaging findings are abnormal. Patients with normal findings in imaging and EEG are not diagnosed as having epilepsy
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Clinical Validation of Selected NIH Cognitive Toolbox Tasks in Pediatric Epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Emily Matuska, Allison Carney, Leigh N. Sepeta, Tesfaye Zelleke, Archana Pasupuleti, Madison M. Berl
The NIH Toolbox Cognition Battery (NIHTB-CB) is designed to assess cognitive functioning across the lifespan. We aimed to evaluate the clinical validity of two NIHTB-CB tasks as cognitive screening tools in pediatric epilepsy by comparing them to standard neuropsychological measures and their association with epilepsy characteristics. Forty-seven patients with epilepsy ages 5–18, including ten repeat
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Diagnostic utility of prolonged ambulatory video-electroencephalography monitoring Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Michael C. Li, Udaya K. Seneviratne, Ewan S. Nurse, Mark J. Cook, Amy J. Halliday
Ambulatory video-electroencephalography (video-EEG) represents a low-cost, convenient and accessible alternative to inpatient video-EEG monitoring, however few studies have examined their diagnostic yield. In this large-scale retrospective study conducted in Australia, we evaluated the efficacy of prolonged ambulatory video-EEG recordings in capturing diagnostic events and resolving the referring question
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Testing the diagnostic accuracy of common questions for seizure diagnosis: Challenges and future directions Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 Ellen Snyder, Stefan Sillau, Kelly G. Knupp, Jacqueline French, Amber Khanna, Marius Birlea, Kavita Nair, Jacob Pellinen
The aim of this study was to evaluate the diagnostic accuracy of common interview questions used to distinguish a diagnosis of epilepsy from seizure mimics including non-epileptic seizures (NES), migraine, and syncope. 200 outpatients were recruited with an established diagnosis of focal epilepsy (n = 50), NES (n = 50), migraine (n = 50), and syncope (n = 50). Patients completed an eight-item, yes-or-no
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Negative MRI and a seizure onset zone close to eloquent areas in FCD type II: Application of MRg-LiTT after a SEEG re-evaluation in pediatric patients with a previous failed surgery Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-23 D. Chiarello, E. Cognolato, S. Francione, G. Nobile, L. Bosisio, G. Barbagallo, M. Pacetti, D. Tortora, G. Cantalupo, L. Nobili, A. Consales
Negative MRI and an epileptogenic zone (EZ) adjacent to eloquent areas are two main issues that can be encountered during pre-surgical evaluation for epilepsy surgery. Focal Cortical Dysplasia type II (FCD type II) is the most common aetiology underlying a negative MRI. Pediatric patients who underwent SEEG followed by MRg-LiTT for drug-resistant epilepsy associated with FCD type II at our Centre were
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Polygenic burden and its association with baseline cognitive function and postoperative cognitive outcome in temporal lobe epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-22 Kayela Arrotta, Lisa Ferguson, Nicolas Thompson, Victoria Smuk, Imad M. Najm, Costin Leu, Dennis Lal, Robyn M. Busch
Demographic and disease factors are associated with cognitive deficits and postoperative cognitive declines in adults with pharmacoresistant temporal lobe epilepsy (TLE), but the role of genetic factors in cognition in TLE is not well understood. Polygenic scores (PGS) for neurological and neuropsychiatric disorders and IQ have been associated with cognition in patient and healthy populations. In this
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Epilepsy and driving: A preliminary survey of people with epilepsy at an epilepsy clinic in China Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-22 Xiantao Li, Yuan Pei, Yan Ge, Lan Xu, Yue Zhang, Li Zheng, Ding Ding, Zhen Hong
Driving is an important part of the daily life for most adults, and restrictions on driving can significantly affect the quality of life for people with epilepsy. This study aimed to investigate the current driving status of patients at an epilepsy clinic in China. Study participants were administered a survey by a questionnaire including the demographic and clinical characteristics of seizure, driving-related
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Seizure control and complications in patients switching from clobazam to clonazepam due to drug shortage Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-21 Oğuzhan Fırat, Melike Çakan, Kutay Demirkan, Neşe Dericioğlu
Antiseizure medication (ASM) shortages are a global problem that have a negative impact on outcomes such as seizure control in patients with epilepsy (PWE). In the case of clobazam (CLB) shortage, there is no study regarding the management strategy. This study aims to investigate the alteration in seizure frequency and the occurrence of side effects in PWE undergoing an abrupt switch from clobazam
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Illness representations of people with later-onset functional seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-20 I.A. Williams, P.G. Morris, K. Forristal, J. Stone, D.C. Gillespie
Although functional seizures can start at any age, little is known about the individuals for whom onset occurs after the age of 40. It has been proposed that health-related traumatic events are more relevant causal factors for people with ‘later-onset functional seizures’ than for those whose functional seizures begin earlier in life, however, the illness representations of people with later-onset
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Mental health and neurodevelopmental patient-reported outcome measures (PROMs) for children and young people with epilepsy: A systematic review Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Bianca De Aveiro, Alice Winsor, Jessica Davies, Timothy R. Nicholson, Deb K. Pal, Mark P. Richardson, Susannah Pick
Children and young people with epilepsy are at higher risk of mental health disorders and atypical neurodevelopmental outcomes compared to the general population. It is essential to detect such comorbidities early in children with epilepsy and provide appropriate interventions, to improve clinical outcomes. We aimed to identify and evaluate the measurement properties of Patient-Reported Outcome Measures
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Risk factors for anxiety in patients with epilepsy: A meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Cailang Niu, Penghong Li, Xueqing Du, Mina Zhao, Haobo Wang, Debo Yang, Maolin Wu, Wei Jing
Epilepsy is a very common neurological disease, and it is important to focus on both controlling seizures and alleviating the psychological problems associated with this disease.Anxiety is an important risk factor for epilepsy and seriously affects the quality of life of patients with epilepsy (PWE). However, several risk factors for anxiety in PWE are relatively controversial and understudied. This
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Prevalence and factors associated with psychosis among adults with epilepsy at a tertiary hospital in Uganda, cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-19 Julius Ceasar Kimera, Etheldreda Mpungu Nakimuli, Andrew Kampikaho Turiho, Jennifer Levin, Martin Kaddumukasa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa
Psychotic disorders are prevalent among people with epilepsy compared to the general population. However, there is limited information regarding psychosis among people with epilepsy in Uganda. This study therefore determined the prevalence and associated factors of psychosis among adults with epilepsy attending Butabika National Referral Mental Hospital in Uganda. This was a cross-sectional study involving
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Response Letter to the Editor: “Expanding eligibility for intracranial electroencephalography using dexmedetomidine hydrochloride in children with behavioral dyscontrol” Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
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Attention-deficit hyperactivity disorder in adults with epilepsy: An indirect relationship with suicide risk Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Eun Ju Choi, Mina Jung, Tae-Young Kim, Boyoung Kim, Sang-Ahm Lee
Studies on attention-deficit hyperactivity disorder (ADHD) are scarce in adults with epilepsy. This study aimed to investigate the risk factors for ADHD and determine whether ADHD is directly associated with the risk of suicide in adults with epilepsy. ADHD was assessed using the Structured Clinical Interview for the DSM-5 Disorders Clinical Version. The Mini International Neuropsychiatric Interview
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Caregiver burden and its predictors in adult epilepsy patients Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Kubra Yeni, Zeliha Tulek, Aysel Cavusoglu, Cansu Polat Dunya, Sevda Ozturk Erden, Nur Sena Bostan, Nerses Bebek, Betul Baykan
The aim of this study was to evaluate caregiver burden and factors associated with caregiver burden in caregivers of adults with epilepsy. This descriptive cross-sectional study was conducted with 107 patients with epilepsy and 107 their primary caregivers. Personal information form including sociodemographic data and Zarit Caregiver Burden Inventory (ZBI), were used for caregivers, and patient information
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Neuropsychological outcome after frontal surgery for pediatric-onset epilepsy with focal cortical dysplasia in adolescent and young adult Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Nobusuke Kimura, Yukitoshi Takahashi, Naotaka Usui, Kazumi Matsuda, Hideyuki Otani, Yoshinobu Kasai, Akihiko Kondo, Katsumi Imai, Junko Takita
We investigated neuropsychological outcome in patients with pharmacoresistant pediatric-onset epilepsy caused by focal cortical dysplasia (FCD), who underwent frontal lobe resection during adolescence and young adulthood. Twenty-seven patients were studied, comprising 15 patients who underwent language-dominant side resection (LDR) and 12 patients who had languagenondominant side resection (n-LDR)
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Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-17 Ronald Oboth, Larrey Kasereka Kamabu, Herve M. Lekuya, Godfrey S. Bbosa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa, Moses Galukande
Post-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care. To determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH). A cross-sectional
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Neutrophil to lymphocyte ratio and early seizures after ischemic stroke: A case-control study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-15 Lea Ebner, Piergiorgio Lochner, Simona Lattanzi, Francesco Brigo, Gudrun Wagenpfeil, Klaus Faßbender, Frauke Röll
Early post-stroke seizures (EPSS) are associated with an increased risk of mortality and post-stroke epilepsy. This study aimed to identify potential risk factors for EPSS, focusing on blood parameters, such as the neutrophil-to-lymphocyte ratio (NLR), which is a biomarker for inflammation. Patients treated for ischemic stroke between 2017 and 2019 were retrospectively identified. 44 of them had a
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Cognitive development in children with new-onset Rolandic epilepsy and Rolandic discharges without seizures: Focusing on intelligence, visual perception, working memory and the role of parents’ education Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-12 Helmut Neumann, Monika Daseking, Charlotte Thiels, Cornelia Köhler, Thomas Lücke
Our aim was to assess intelligence, visual perception and working memory in children with new-onset Rolandic epilepsy (RE) and children with Rolandic discharges without seizures (RD). The participants in the study were 12 children with RE and 26 children with RD aged 4 to 10 years (all without medication and shortly after diagnosis) and 31 healthy controls. Their cognitive performance was assessed
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The burden of epilepsy on long-term outcome of genetic developmental and epileptic encephalopathies: A single tertiary center longitudinal retrospective cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-08 Mario Mastrangelo, Filippo Manti, Giacomina Ricciardi, Rossella Bove, Carlo Greco, Manuela Tolve, Francesco Pisani
This retrospective cohort analysis highlighted neurodevelopmental outcome predictors of genetic developmental and epileptic encephalopathies (DEE). Patients’ demographic, clinical and molecular genetics data were collected. All patients underwent clinical, developmental, and neuropsychological assessments. We recruited 100 participants (53 males, 47 females) with a mean follow-up lasting 10.46 ± 8
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The lived experience of young adults with Fetal Valproate Spectrum Disorder, and the perspective of their parents: A qualitative study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-08 S Khanom, D Astill, N Astill, J Cozens, B Mann, J Garratt, R L Bromley
While research has investigated the physical and neurodevelopmental consequences following prenatal exposure to valproate, our understanding of individuals with a formal diagnosis of Fetal Valproate Spectrum Disorder (FVSD), particularly in the context of adulthood, remains limited. To investigate how symptoms and challenges of FVSD present in adulthood. 30 people took part in the study, including
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CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-06 Natalie A. Cashen, Michelle L. Kloc, Davi Pressman, Samuel A. Liebman, Gregory L. Holmes
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Quality of life in people with epilepsy: The associations of anti-seizure medications and biopsychosocial variables Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-05 Julia A. Thomas, Nicole M. Ditchman, Leslie Guidotti Breting, Jaishree Narayanan
People with epilepsy, on average, experience lower quality of life (QOL) than healthy controls. This study examined the associations between specific anti-seizure medications, biopsychosocial factors, and QOL in people with epilepsy. Analysis of covariance revealed that individuals taking three or more anti-seizure medications had significantly lower QOL than those taking levetiracetam. Findings also
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Development and construction of the Multidimensional Self-Efficacy Scale for Epilepsy (MSESE) and its psychometric properties Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-31 Che-Wei Lin, Hsiang-Yu Yu, Chien-Chen Chou, Ren-Hau Li, Yi-Jiun Lu, Wei-Han Wang
Purpose It has become evident that patients with epilepsy require strong self-efficacy support in various domains, including work, social interaction, and academic performance, to ensure their complete social functioning. Nevertheless, previous studies have predominantly assessed the self-efficacy of individuals with epilepsy from a singular perspective of disease management. This study aimed to develop
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The crosstalk between epilepsy and dementia: A systematic review and meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-31 Lu Chen, Wenqian Yang, Fei Yang, Yanying Yu, Tingwan Xu, Dan Wang, Qingqing Zhao, Qian Wu, Yanbing Han
Background Epilepsy and dementia are bidirectional. The purpose of this review was to investigate the epidemiological characteristics of and to identify the risk factors for epilepsy in patients with dementia and dementia in patients with epilepsy. Methods We retrieved the PubMed, Embase, Cochrane and Web of Science databases through January 2023. Two individuals screened the articles, extracted the
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How do children with focal epilepsies perceive the moment they realize that they are about to have a seizure? A pilot study Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-01 Sarah Jeschke, Mathilda Charisius, Sarah Lange, Thilo Bertsche, Phoebe Makiello, Martina P. Neininger, Astrid Bertsche
A seizure is a challenging situation for children with epilepsy. Little is known regarding the experience of children who perceive in advance that they are about to have a seizure. From September 2020 to February 2021, we invited children with focal epilepsies aged 6–18 years to participate in a semi-structured interview. Of 52 children with focal epilepsies, 22 (42 %) said they perceive in advance
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Elevated phase amplitude coupling as a depression biomarker in epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-02-01 James J. Young, Andy Ho Wing Chan, Nathalie Jette, Heidi A. Bender, Adam E. Saad, Ignacio Saez, Fedor Panov, Saadi Ghatan, Ji Yeoun Yoo, Anuradha Singh, Madeline C. Fields, Lara V. Marcuse, Helen S. Mayberg
Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients’ brain recordings. The values of spectral power and PAC for
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Association between cognitive impairment and antiseizure medication adherence among people with epilepsy in Addis Ababa, Ethiopia Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-31 Blen Mamo, Anteneh M. Feyissa, Tariku Mengesha, Biniyam A. Ayele, Yared Mamushet Yifru
Background Cognitive impairment is one of the most common and most troublesome comorbidities among people with epilepsy (PWE). Adherent use of antiseizure medications (ASM) can control seizure episodes in 70% of the cases. However, the relationship between adherent use of ASMs and cognitive impairment in epilepsy is complex. Objective To assess the association between adherence to ASMs and cognitive
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Management of patients with epilepsy and Intellectual disabilities in group homes vs. Family Homes: Insights into polypharmacy and seizure characteristics Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-30 Norah A. ALKhaldi, Michelle Tu, Ana Suller Marti, Azra Zafar, Christine Le, Derek Debicki, Seyed M. Mirsattari
Objectives This study aimed to investigate the differences in ASMs prescription, seizure characteristics and predictors of polypharmacy in patients with epilepsy and Intellectual disabilities (IDs) residing in group homes versus family homes. Methods This nine-year retrospective study analyzed patients with epilepsy and IDs who were admitted to the EMU, epilepsy clinics at LHSC and rehabilitation clinics
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Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: An observational, retrospective cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-28 Jing Jiang, Yu-Jiao Wu, Cui-Hua Yan, Yang Jin, Ting-Ting Yang, Tao Han, Xue-Wu Liu
Objective To evaluate the therapeutic efficacy and safety of agomelatine for treating the sleep and mood disorders in epilepsy patients. Methods Retrospective data were derived from 113 epilepsy patients for at least 8 weeks. All the subjects were divided into two groups, one was treated with agomelatine, the other was treated with escitalopram. Their depression and anxiety states were assessed by
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Historical roots of the stigma of epilepsy: A review of the classic Iranian literature Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-26 Mohsen Farjoud Kouhanjani, Seyed Ali Hosseini, Ali A. Asadi-Pooya, Mojtaba Heydari, Seyed Mohammad Hadi Hosseini, Hakimeh Khatoon Farjoudi Kouhanjani
Background The stigma toward epilepsy is a daily challenge for people with epilepsy (PWE) and can influence the well-being and prognosis of these individuals. However, the cultural origins of such stigma have sparsely been examined. In this study, we aimed to investigate the classic Persian literature to gain insight into the historical and cultural beliefs and opinions regarding epilepsy as a determinant
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Structural and functional changes associated with functional/dissociative seizures: A review of the literature Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-28 Johann Hassan, Simon Taib, Antoine Yrondi
Introduction The term ‘functional/dissociative seizures (FDS)’ refers to a paroxysmal, transient clinical manifestation that may include motor, sensory, vegetative, psychological and cognitive signs, similar to the manifestations observed in epileptic seizures. In recent years, there has been an increase of literature in the field of brain imaging research on functional neurological disorders and,
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Efficacy and safety of six new antiseizure medications for adjunctive treatment of focal epilepsy and epileptic syndrome: A systematic review and network meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Jingyi Tong, Tingting Ji, Ting Liu, Jiaqi Liu, Yibin Chen, Zongjun Li, Na Lu, Qifu Li
Objective This study aimed to evaluate the efficacy and safety of six new antiseizure medications (ASMs) for adjunctive treatment in adult patients with focal epilepsy and adolescents with Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC). Methods A comprehensive literature search was performed using PubMed, Medline, Embase, and Cochrane library databases from
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Psychiatric comorbidity in people with epilepsy in Ethiopia: Systematic review and meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Techilo Tinsae, Shegaye Shumet, Mamaru Melkam, Tesfaye Segon, Girmaw Medfu Takelle, Gidey Rtbey, Girum Nakie, Setegn Fentahun, Fantahun Andualem, Wondale Getinet
Background Psychiatric comorbidity is a double burden among people with epilepsy. Since people with epilepsy are more vulnerable to psychiatric illnesses. So, the implementation of an appropriate intervention to minimize the double burden of comorbidity is very important. Therefore, this systematic review and meta-analysis aimed to assess the prevalence and associated factors of psychiatric comorbidity
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The effect of executive function on health related quality of life in children with self-limited epilepsy with centrotemporal spikes Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Martina Paola Zanaboni, Ludovica Pasca, Stefania Bergamoni, Stefania Maria Bova, Massimiliano Celario, Elena Freri, Serena Grumi, Melissa Filippini, Valeria Leonardi, Serena Micheletti, Francesca Felicita Operto, Amanda Papa, Grazia Maria Giovanna Pastorino, Cinzia Peruzzi, Dario Pruna, Francesca Ragona, Federico Raviglione, Martina Totaro, Costanza Varesio, Valentina De Giorgis
Aim The current study aims to investigate the effect of Executive Functions (EFs) on Health Related Quality of Life (HRQoL) in a cohort of children with self-limited epilepsy with centrotemporal spikes (SeLECTS) and to identify possible factors that impact HRQoL specifically related to epilepsy-related variables and EFs skills. Material and method The Pediatric Quality of Life Inventory 4.0 Generic
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Dual diagnosis of epilepsy and dissociative seizures: Prescription patterns, feasibility and safety of rationalising antiseizure medication Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Andrew Whitfield, Emma Leighton, Heather Boagey, Maria Oto
Background Patients with a dual-diagnosis of epilepsy and dissociative seizures (DS) have received far less attention than those with single pathology. Anti-seizure medication (ASM) prescription patterns and safety of rationalisation have not been reviewed. Methods We undertook a retrospective cohort study of all patients with a dual-diagnosis admitted to the Scottish Epilepsy Centre between 2012–2020
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The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Mehmet Emin Düken, Mürşide Zengin
Aim This study was conducted to examine the mediating role of social support in the relationship between psychosocial problems of adolescents with epilepsy and their sleep patterns. Methods The data were collected with Adolescent Information Form, Strength and Difficulties Questionnaire, Sleep Disturbance Scale for Children and Multidimensional Scale of Perceived Social Support in this descriptive
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Prevalence of and factors associated with the early prescription of antiseizure medications in adults newly diagnosed with epilepsy in Germany Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-24 Karel Kostev, Corinna Doege, Louis Jacob
Background There is little information on prescription patterns of antiseizure medications (ASMs) during the early management of patients with epilepsy in Germany. Therefore, this study investigated the prevalence of and the factors associated with ASM prescription in patients newly diagnosed with epilepsy in this country. Methods Adults diagnosed for the first time with epilepsy in one of 128 neurology
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Preferences and experiences of parents/guardians of youth with epilepsy and intellectual disability on reproductive health counseling Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Geetha Vasudevan, Robyn Filipink, Jenna Gaesser, Traci M. Kazmerski, Yoshimi Sogawa, Laura Kirkpatrick
Objective To explore the experiences and preferences of parents/guardians of adolescents and young adults (AYA) of childbearing potential with co-occurring epilepsy and intellectual disability (ID) regarding counseling by neurologists on sexual and reproductive health (SRH) topics such as pregnancy, contraception, menstruation, and folic acid supplementation. Methods We conducted semi-structured interviews
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Trends in enzyme-inducing antiseizure medication use: A retrospective analysis among adults with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Revital Gandelman-Marton, Jacques Theitler
Background Enzyme-inducing antiseizure medications (EIASMs) were associated with drug interactions and long-term adverse effects. Therefore, it was suggested that epilepsy treatment should be started with non-EIASMs, and in patients treated with EIASMs, replacement with non-EIASMs should be evaluated Objective To assess potent EIASM use among patients with epilepsy at their first visit in our epilepsy
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Greater need for treatment optimization in patients with epilepsy initiating adjunctive therapy: Results of a retrospective claims analysis of antiseizure medication drug load in the United States Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Gregory S. Connor, David M. Labiner, Vernon F. Schabert, Mindl Weingarten, Clarence T. Wade, Sean Stern, Danielle A. Becker
Background This retrospective, observational study used US claims data to assess changes in antiseizure medication (ASM) drug load for a cohort of patients with epilepsy. Methods Adults (≥18 years) with a diagnosis of epilepsy (ICD-10 code G40.xxx) who started new adjunctive ASM treatment with one of 4 branded (brivaracetam, eslicarbazepine, lacosamide, perampanel) or 4 unbranded (carbamazepine, lamotrigine
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Hypertension and other vascular risk factors in patients with functional seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-25 Jonah Fox, Murli Mishra
Objective Recent literature has suggested that functional seizures are associated with an elevated risk for vascular disease and mortality. We investigated the prevalence of risk factors for vascular disease in patients who were admitted to the epilepsy monitoring unit. Methods Patients who were admitted to the epilepsy monitoring unit and received a definitive diagnosis of either functional seizures
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The physician’s role in reducing health disparities for persons with epilepsy and intellectual disability: “it’s not just epilepsy…you really have to take a deeper dive.” Epilepsy Behav. (IF 2.6) Pub Date : 2024-01-24 Emma Casey, Christine Linehan
Epilepsy affects approximately 25 % of people with intellectual disability (ID). Despite this high prevalence, evidence of health disparity exists in healthcare access and health outcomes for this population. Patients with ID experience additional challenges in accessing appropriate epilepsy care, and are at greater risk of experiencing inappropriate prescribing, polypharmacy and misdiagnosis compared