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Preparations Based on Regulatory Peptides—a New Class of Medicines Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 V. N. Fedorov, S. V. Koroleva, T. A. Zubova, L. A. Andreeva, N. F. Myasoedov
Abstract—Regulatory peptides have modulatory and integrative functions defining communication between different systems of the body. This review summarizes and systematizes the data on drugs created on the basis of peptide regulators. The therapeutic profiles of a wide range of oligopeptides are considered in various body systems: nervous, cardiovascular, digestive, immune, endocrine, etc. The data
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Elevated Neutrophil/Lymphocyte Ratio in Adolescents with Early-onset Schizophrenia Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 Arif Önder, Aslı Sürer Adanır, Özge Gizli Çoban, Öznur Bilaç, Canem Kavurma
Abstract— Inflammation plays a substantial role in the pathophysiology of schizophrenia. The neutrophil to lymphocyte ratio (NLR) is a cost-effective and simple indicator of inflammation, which it is widely used as a proxy of systemic inflammation. In this retrospective study, we investigated the relationship between NLR and early-onset schizophrenia. Hematologic parameters and Positive and Negative
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Metabolomic Analysis of the Serum in Rats with Methamphetamine-Induced Conditioned Place Preference Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 Changli Zeng, Xiaokang Gong, Xigang Dai, Tingting Ning
Abstract To understand what happens in the serum after methamphetamine (MA) administration, nuclear magnetic resonance-based metabolomics was performed to investigate the characteristic metabolite profile in the serum of rats with MA-induced conditioned place preference. The results showed that tyrosine concentration was significantly higher in the MA-induced group (1.68 × 10–5 ppm) than in the control
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Molecular and Cellular Mechanisms Regulating Quiescence and Division of Hippocampal Stem Cells Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 D. I. Mal’tsev, O. V. Podgornyi
Abstract—Neurogenesis in the dentate gyrus of the hippocampus occurs throughout the life of mammals, including humans. A common view is that integration of newborn neurons provides a high level of plasticity in the hippocampal neuronal network. This is important for cognitive brain function, memory formation, and emotions. Neurogenesis is supported by the pool of stem cells located in the subgranular
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Identification of Kinome Representatives with Neuroprotective Activity Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 E. V. Mitroshina, T. A. Mishchenko, M. M. Loginova, V. S. Tarabykin, M. V. Vedunova
Abstract—Regulation of adaptive mechanisms in the central nervous system in cerebrovascular disorders and during the development of pathological processes is an urgent problems in neurobiology and medicine. Kinases, enzymes that perform a wide range of functions in the central nervous system, are of great interest as molecular targets and possible therapeutic agents in various neurodegenerative processes
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Possible Mechanisms of the Influence of the Supramillary Nucleus on the Functioning of the Dentate Gyrus and the CA2 Field of the Hippocamsus (Role of Disinhibition) Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 I. G. Silkis, V. A. Markevich
Abstract—We analyzed possible mechanisms of the influence of the supramammillary nucleus of the hypothalamus (SMN) on the activity of granule cells of the dentate gyrus and pyramidal neurons of the CA2 field of the hippocampus. We used known data on the functional organization of excitatory and inhibitory interactions in the neural network, which includes the SMN, hippocampus, septum, and entorhinal
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Generation and Characteristics of Glial Cells from Induced Human Pluripotent Stem Cells Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 E. V. Novosadova, E. L. Arsen’eva, S. A. Antonov, E. A. Kazantseva, L. V. Novosadova, O. D. Kurko, S. N. Illarioshkin, V. Z. Tarantul, I. A. Grivennikov
Abstract—The technology for producing human induced pluripotent stem cells (iPSCs) and the possibility of directed differentiation into specialized cells of all body tissues have opened unique opportunities for studying the molecular genetic basis of the pathogenesis of neurodegenerative diseases in vitro and effective screening for compounds with neuroprotective activity. The aim of this work was
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Changes in Inflammatory Mediators Depending on the Level of Depression in Workers Chronically Exposed to Mercury Vapors Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 G. M. Bodienkova, E. V. Boklazhenko, O. I. Shevchenko
Abstract—The aim of the study was to identify changes in serum concentrations of pro- and anti-inflammatory cytokines in workers exposed to metallic mercury vapors and in patients with chronic mercury intoxication (CMI), depending on the level of depression. We found unidirectional changes in the cytokine profile in workers with moderate and severe depression chronically exposed to vapors of metallic
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Activation of Serotonin System in the Medial Prefrontal Cortex by Sound Signals of Danger Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 N. B. Saul’skaya, O. E. Marchuk, M. A. Puzanova, N. A. Trofimova
Abstract—Intracerebral microdialysis in Sprague-Dawley rats showed that a conditioned sound signal (CS+) previously reinforced by unavoidable electrocutaneous stimulation (fear conditioning test) is accompanied by an increased level of extracellular serotonin in the medial prefrontal cortex and provokes freezing behavior (fear index). A differential sound signal (CS–) not associated with pain stimulation
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Trace Amines and Behavior Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 D. A. Zhukov, E. P. Vinogradova
Abstract—Trace amines are similar in structure to catecholamines and serotonin of the central nervous system but are present at much lower concentrations. Trace amines such as tyramine, tryptamine, octopamine, and β-phenylethylamine, bind to highly specific receptors that have low affinity for catecholamines and serotonin. Several types of trace amine receptors have been identified. Trace amine-associated
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Investigation of the Brain Serotonin System Plasticity Using the Recombinant Mouse Lines Carring 1473G–Allele of Tryptophan Hydroxylase-2 Gene and Differing by the Distal Fragment of Chromosome 13 Containing 5-HT 1A Receptor Gene Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 A. Ya. Rodnyy, I. I. Belokopytova, E. V. Antonov, V. S. Naumenko, E. M. Kondaurova
Abstract—In order to investigate the joint influence of C1473G polymorphism in the gene encoding the key enzyme for serotonin (5-HT) biosynthesis in brain – tryptophan hydroxylase-2, and the distal fragment (103,9-112,4 Мbp) of chromosome 13, including 5-HT1A serotonin receptor gene from catalepsy-prone CBA strain, on the brain 5-HT system, new recombinant mice strain B6-1473GG.CBA-CD13Mit76С (1473GG-76C)
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Ischemic Stroke and Depression Biomarkers: Are There Specific Markers for Post-Stroke Depression? Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 M. Yu. Kasatkina, I. S. Zhanin, N. V. Gulyaeva
Abstract—Post-stroke depression (PD) is a complex multifactorial disease that affects over 30% of stroke survivors. Despite the high prevalence of the disease, important aspects of its classification, etiology, and pathogenesis are still not fully understood, which is complicated even further by significant difficulties in diagnostics and prevention. Subjective depression rating scales and physical
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Saliva Biomarkers in Diagnostics of Early Stages of Alzheimer’s Disease Neurochem. J. (IF 0.414) Pub Date : 2020-12-16 A. N. Kodintsev, O. P. Kovtun, L. I. Volkova
Abstract—Diagnosis of Alzheimer’s disease (AD) is based on clinical examination of patient’s cognitive state. In 2018, the A/T/N system was developed, which expanded a spectrum of biomarkers recommended for AD diagnostics. However, the high price and low availability of the suggested methods, including lumbar puncture or positron-emission tomography, limit their use in daily clinical practice. An active
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Induction of Transporter Protein Glycoprotein-P in the Blood–Brain Barrier as a Way to Prevent Parkinson’s Syndrome Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 M. M. Gradinar’, I. V. Chernykh, A. V. Shchul’kin, A. S. Yesenina, E. N. Yakusheva
Abstract—In this study, we evaluated the prospect of induction of the transporter protein glycoprotein-P (Pgp) in the blood–brain barrier for the prevention of development of Parkinson’s syndrome caused by the administration of the neurotoxin rotenone. The study was performed with 48 male rats. The first group of animals was injected subcutaneously with sunflower oil (1 mL/kg) for 28 days; the second
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The Content and Activity of Hypoxia-Inducible Factor HIF1α Increased in the Hippocampus of Newborn Rats That Were Subjected to Prenatal Hypoxia on Days 14–16 of Embryogenesis Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 O. V. Vetrovoy, P. P. Nimiritsky, E. I. Tyulkova, E. A. Rybnikova
Abstract—Western blot and quantitative real-time PCR were used to study the content of the regulatory alpha subunit of hypoxia-inducible factor-1 (HIF1α), and the mRNA content of the HIF1-regulated genes lactate dehydrogenase A (ldha) and glucose-6-phosphate dehydrogenase (g6pd) in the hippocampus of 1-day old rat pups whose mothers were subjected to three sessions of severe damaging hypoxia on days
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Predominance of Nootropic or Anxiolytic Effects of Selank, Semax, and Noopept Peptides Depending on the Route of Administration to BALB/c and С57BL/6 Mice Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 E. V. Vasileva, E. A. Kondrakhin, A. A. Abdullina, R. M. Salimov, G. I. Kovalev
Abstract—The pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of the peptides selank (300 µg/kg/day), noopept (1 mg/kg/day), and semax (0.6 mg/kg/day), which are known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze (EPM) behavior of inbred BALB/c and C57BL/6 mice, and studying their effects on NMDA- and mGluII-
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Influence of Prenatal Hypoxia on the Content of Neuron Specific Enolase in the Structures of the Brain and Blood Serum of Rats in Early Ontogeny Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 A. Yu. Morozova, A. V. Arutjunyan, Yu. P. Milyutina, P. Yu. Morozova, L. S. Kozina, I. A. Zhuravin
Abstract—We studied the dynamics of changes in the content of neuron specific enolase (NSE, EC 4.2.1.11) in the hippocampus, cortex, cerebellum and blood serum of rats at 5th, 10th, and 30th days of postnatal development. It was shown that during the first month of life the content of NSE increases several-fold in all the structures studied, both after hypoxia and in the animals not exposed to hypoxia
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Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 G. V. Karantysh, M. P. Fomenko, A. M. Menzheritskii, V. N. Prokof’ev, G. A. Ryzhak, E. V. Butenko
Abstract—We studied the effect of the peptide drug pinealon (Glu-Asp-Arg) at doses of 50, 100, and 200 ng/kg on the training of rats in the Morris maze and the maintenance of the acquired skill after the development of experimental diabetes. We also studied the changes in the subunit composition of NMDA receptors in the hippocampus in these experimental models. In the Morris water maze, spatial learning
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Localization of Annexin V and Agrin in the Intact Sciatic Nerve of Mice Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 G. F. Shaymardanova, V. V. Salnikov
Abstract Immunohistochemistry methods are widely used in modern microscopic studies. The advantage of immunoelectron microscopy is the possibility of localization of functional proteins in the ultrastructures of the cell. However, different tissues and antigens react differently to the traditionally used fixatives. Selection of optimal conditions for the preparation of immunologically labeled samples
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Exosomal Angiogenin as a Potential Biomarker in Amyotrophic Lateral Sclerosis Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 M. V. Ivanova, E. O. Chekanova, B. V. Belugin, I. V. Dolzhikova, I. L. Tutykhina, M. N. Zakharova
Abstract—Exosomes are extracellular vesicles that represent an important mode of intercellular communication. It is thought that exosomes can carry biologically active molecules associated with the progressive spreading of amyotrophic lateral sclerosis (ALS). ALS is a fatal neurodegenerative disease characterized by the progressive death of motor neurons. Angiogenin is likely to be important in th
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Exploration of Acetylcholinesterase Inhibitors from Flavonoids and Flavonoid Glycosides Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 Peng Zhou, Fang Hua
Abstract A few organic synthetic drugs, such as donepezil, rivastigmine and tacrine, are used for inhibition of acetylcholinesterase (AChE) can provide palliative treatment without generally affecting the progression of the disease, however, sometimes at the cost of severe side effects. Flavonoids and flavonoid glycosides are the potential natural compounds from plants and foods for the treatment of
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Preconditioning by Moderate Hypoxia Increases the Amount of Corticosteroid Receptors in the Rat Brain in a Model of Depression Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 K. A. Baranova
Abstract—The involvement of corticosteroid brain receptors in the antidepressant-like effects of moderate hypobaric hypoxia was studied in a rat model of depression (the learned helplessness paradigm) using immunohistochemistry. The formation of a depressive-like state is accompanied by a significant deficiency in glucocorticoid receptors in the brain which is most pronounced in the dentate gyrus of
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Classical Model of 6-Hydroxydopamine-Induced Parkinsonism in Rats Is Characterized by Unilateral Lesion of Brain Mesolimbic System Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 A. V. Stavrovskaya, D. S. Berezhnoy, D. N. Voronkov, S. L. Stvolinskii, D. A. Abaimov, A. S. Ol’shanskii, A. S. Gushchina, N. G. Yamshchikova, T. N. Fedorova
Abstract—Localizing lesions in the brain of rodents after administration of neurotoxic 6-hydroxidopamine (6-OHDA) is important for understanding the mechanisms of progression of parkinsonism. The present study provides the results of behavioral tests, immunohistochemistry, and measurements of dopamine (DA) level in different areas of the striatum 25 days after unilateral intranigral injection of 6-OHDA
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The Influence of Stress on the Expression of Brain-Derived Neurotrophic Factor (BDNF) and Its Precursor proBDNF in Mice with Different Sensitivity of Serotonin 5-HT1A Receptors Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 E. M. Kondaurova, T. V. Il’chibaeva, D. V. Bazovkina, N. K. Popova, V. S. Naumenko
Abstract—Recently, it has become apparent that the interaction between the serotonin (5-HT) system and the brain-derived neurotrophic factor (BDNF) system plays an important role in the regulation of behavior, and in various physiological and neuroplasticity processes. Moreover, there is data indicating the involvement of the 5-HT1A receptor, a key regulator of the central serotonergic system, in the
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Biogenic Monoamines, Their Precursors, and Metabolites in the Brain of Rats under Experimental Circulatory Failure Neurochem. J. (IF 0.414) Pub Date : 2020-09-23 Ye. M. Doroshenko, V. V. Lelevich
Abstract—The aim of the study was to establish the effect of experimental chronic circulatory failure on the levels of biogenic monoamines, their precursors, and their metabolites in rat brain structures. Thirteen weeks after experimental narrowing of the abdominal aorta to 1 or 0.7 mm, the levels of biogenic monoamines, their precursors, metabolites, kynurenine, and kynurenic acid were measured by
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Binding of Colchicine to Tubulin in the Brain Structures in Normal Conditions and in Schizophrenia Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 G. Sh. Burbaeva; L. V. Androsova; O. K. Savushkina
Abstract—One of the components of the cytoskeleton is microtubules (MT), a complex intracellular system, damage to which may cause disturbances that lead to the development of pathological processes in the cell. This gives rise to the study of tubulin, the main MT protein, in schizophrenia. To assess the relative amount of tubulin, its specific property to bind colchicine at an equimolar ratio was
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Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor in Patients with Depression Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 A. A. Shpak; A. B. Guekht; T. A. Druzhkova; M. S. Zinchuk; N. V. Gulyaeva
Abstract—We studied the content of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) in serum and lacrimal fluid in 105 patients with depression (unipolar depression, 37 and bipolar depression, 68). The stimulated lacrimal fluid was taken from one randomly selected eye with a pipette dispenser. The concentrations of BDNF and CNTF were determined by enzyme-linked immunosorbent
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Influence of Prenatal Stress on the Activity of Antioxidant Enzymes in the Subcellular Fractions of the Neurons and Neuroglia of the Rat Neocortex Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 A. V. V’yushina; A. V. Pritvorova; O. G. Semenova; N. E. Ordyan
Abstract—We studied the effect of prenatal stress on the activity of glutathione-bound enzymes in the subcellular fractions of neurons and neuroglia of rat neocortex. The results of the study showed that prenatal stress causes changes in the activity of these enzymes in both neurons and neocortical neuroglia. These changes differ in the subcellular fractions of the studied cell populations. In the
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The Capability to Learn and Expression of the Insulin-Like Growth Factor II Gene in the Brain of Male Rats Whose Fathers Were Subjected to Stress Factors in the “Stress–Restress” Paradigm Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 N. E. Ordyan; O. V. Malysheva; V. K. Akulova; S. G. Pivina; G. I. Kholova
Abstract—We studied the capability to learn in a passive avoidance task and the rate of its extinction in male rats whose fathers were subjected to stress during the period of spermatogenesis using the “stress–restress” paradigm (a model of post-traumatic stress disorder). In the brain of trained and untrained rats, we studied the expression of genes encoding insulin-like growth factor II and H19,
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The Role of Reduced Polyamine Synthesis in Ischemic Stroke Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 B. Cigdem; A. Bolayir; V. K. Celik; S. Kapancik; H. Kilicgun; S. F. Gokce; A. Gulunay
AbstractOur aim was to determine the levels of arginine decarboxylase (ADC), ornithine decarboxylase (ODC) and agmatine, ornithine, nitric oxide (NO) and arginase activity in the acute and subacute phases of acute ischemic stroke (AIS), by revealing the possible role of these levels in neuroinflammation and neurogenesis that are postulated to begin after AIS. 35 patients diagnosed with AIS and 35 controls
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Synthesis of L-Dihydroxyphenylalanine by Monoenzymatic Tyrosine Hydroxylase-Containing Nerve Fibers in the Suprachiasmatic Nucleus in Rats during Ontogeny Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 T. S. Pronina; Yu. O. Nikishina; L. K. Dil’mukhametova; A. R. Murtazina; M. V. Ugryumov
Abstract—The suprachiasmatic nucleus (SCN) regulates the functioning of the body in accordance with circadian rhythms thanks to the pacemaker neurons present in it and afferents modulating these neurons. One of the afferents is represented by nerve fibers containing only the first enzyme for the synthesis of catecholamines, tyrosine hydroxylase (TH). In ontogeny, the concentration of these fibers (amount
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Role of Acetylcholine and GABAergic Inhibitory Transmission in Seizure Pattern Generation in Neural Networks Integrating the Neocortex, Hippocampus, Basal Ganglia, and Thalamus Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 I. G. Silkis
Abstract—We have analyzed the influence of acetylcholine and GABAergic inhibitory transmission on the functioning of parallel topically organized cortico-basal ganglia–thalamo-cortical neural loops including prefrontal and sensory neocortical areas and the hippocampo-basal ganglia–thalamo–hippocampal loop. Abnormal changes in the acetylcholine concentration as well as in the efficiency of excitation
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Synthesis of Dopamine by Non-Dopaminergic Neurons Containing Aromatic Amino Acid Decarboxylase in the Suprachiasmatic Nucleus of Rats in Ontogeny Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 T. S. Pronina; L. K. Dil’mukhametova; Yu. O. Nikishina; A. R. Murtazina; M. V. Ugryumov
Abstract—The suprachiasmatic nucleus (SCN) regulates functions in accordance with circadian rhythms thanks to the pacemaker neurons present in it and afferents modulating their activity. One type of afferent is nerve fibers containing only tyrosine hydroxylase (TH) and secreting (L-dihydroxyphenylalanine) L-DOPA. The aim of this work was to test the hypothesis that L-DOPA comes from TH-containing fibers
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Analysis of Quinone Reductase 2 Implication in Mechanism of Antiparkinsonian Action of Afobazole Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 I. A. Kadnikov; D. N. Voronkov; M. V. Voronin; S. B. Seredenin
Abstract—In an experimental model of Parkinson’s disease, the dopamine content in the striatum, the density of TH+ neurons in the substantia nigra, and the motor activity of mice were studied after the administration of afobazole, which interacts with Sigma-1 and MT1 receptors and regulatory sites of MAO-A and quinone reductase 2 (NQO2, MT3 receptor), and its main metabolite M-11, which selectively
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Expression Patterns of Serotonin Receptors 1А and 7 in the Brain of Rats with Genetically Determined Fear-Induced Aggressive Behavior or the Lack of Aggression Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 T. V. Ilchibaeva; A. S. Tsybko; E. M. Kondaurova; A. I. Kovetskaya; R. V. Kozhemyakina; V. S. Naumenko
Abstract—Serotonin receptors of subtype 1А (5-HT1A) are involved in the regulation of aggressive behavior. New data show that 5-HT1A receptors are capable of heterodimerization and antagonistic interaction with type 7 serotonin receptors (5-HT7); hence, it is important to study the involvement of 5-НТ7 receptors in aggressive behavior. Specifically, it is necessary to study the patterns of co-expression
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Effect of 3-Oxypyridine Derivatives and Succinic Acid on the Activity of Monoamine Oxidases and the Content of Monoamines in the Hypothalamus of Rats with Alloxan-Induced Diabetes Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 I. A. Volchegorskii; A. I. Sinitskii; I. Yu. Miroshnichenko; L. M. Rassokhina
Abstract—We studied the effect of novel domestic derivatives of 3-oxypyridine and succinic acid (emoxypine, reamberin, and mexidol) on the activity of monoamine oxidases (MAO-A and MAO-B) and the level of biogenic amines (serotonin and dopamine) in the hypothalamus during the first two weeks of alloxan-induced diabetes in rats. During the first 14 days of alloxan-induced diabetes in rats, the levels
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Time Course of Peripheral and Central Immune System Alterations in Paclitaxel-Treated Mice: Possible Involvement of Dysfunctional Microglia Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 Jong Wan Kim; Hyun-Sun Park; Min-Jung You; Bohyun Yang; Kyu Beom Jang; Min-Soo Kwon
AbstractDespite the importance of microglial cells in chronic pain, the mechanisms of microglial engagement remain controversial. In this study, we examined the changes in immune-related factors in the mesenteric lymph node and spinal cord over time as a treatment regimen for paclitaxel-induced neuropathy (2 mg/kg/day for 5 days). Our data showed that expression of pro- and anti-inflammatory cytokines
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The Role of MicroRNA in the Pathogenesis and Diagnostics of Parkinson’s Disease Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 N. S. Ardashirova; E. Yu. Fedotova; S. N. Illarioshkin
Abstract—Lately the investigation of non-coding RNAs that play an important role in epigenetic regulation of gene expression, along with the methylation of DNA and modification of histones, has begun. MicroRNAs of 19–24 nucleotides in length are the most studied class. Currently over 5000 various microRNAs have been identified in the human epigenome, and that number is constantly increasing. MicroRNAs
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The Neurochemical Changes Involved in Immobilization Stress-Induced Anxiety and Depression: Roles for Oxidative Stress and Neuroinflammation Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 Kiarash Fekri; Alireza Mohajjel Nayebi; Saeed Sadigh-Eteghad; Fereshteh Farajdokht; Javad Mahmoudi
AbstractLong-term exposure to stressful conditions is associated with neurochemical changes in the cerebral structures, which ultimately result in mood disorders including, but not limited to, depression and anxiety. Finding an effective way to deal with these conditions has always been of interest to researchers. The goal of this review was to discuss the biochemical pathways and mechanisms restraint/immobilization
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The Reduction of Seizure Intensity and Attenuation of Memory Deficiency and Anxiety-Like Behavior through Aerobic Exercise by Increasing the BDNF in Mice with Chronic Epilepsy Neurochem. J. (IF 0.414) Pub Date : 2020-06-11 A. Sabaghi; A. Heirani; A. Kiani; N. Yousofvand; S. Sabaghi
AbstractEpilepsy is a disease characterized by recurrent and unprovoked seizures. Cognitive deficiency and anxiety are important comorbidities of the chronic epilepsy. Studies on epilepsy using human and animal models have shown that aerobic exercise (AX) induces beneficial structural and functional changes and reduce the intensity of seizures. The present study seeks to evaluate effects of an AX program
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Content of Monoamines in the Pons Varolii in Experimental Post-Traumatic Stress Disorder Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 V. E. Tseilikman; M. V. Komel’kova; M. S. Lapshin; O. B. Tseilikman; M. N. Karpenko; N. S. Pestereva; E. B. Manukhina; G. F. Downey; M. V. Kondashevskaya
Abstract—In posttraumatic stress disorder (PTSD), the development of anxiety symptoms correlates with an increase in the content of noradrenaline and dopamine and a decrease in the content of serotonin in the limbic structures of the brain. Unfortunately, the character of changes in the level of monoamines in the brain stem structures such as the pons Varolii is not known, although it is damaged in
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A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 Sara T. Alrashood; Mohamed S. Elrobh; Salman Alamery; Hamza A. Odeibat; Haseeb A. Khan
AbstractIminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype
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Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 M. N. Volobueva; Yu. V. Dobryakova; A. O. Manolova; M. Yu. Stepanichev; A. A. Kvichansky; N. V. Gulyaeva; V. A. Markevich; A. P. Bolshakov
Abstract—The immunotoxin 192IgG-saporin is a powerful tool for inducing the selective death of cholinergic neurons in the basal nuclei. In this study, we investigated the effect of intracerebroventricular immunotoxin administration on the state of microglia in tissues adjacent to the ventricle (striatum and parietal cortex) and remotely located but receiving innervation from the medial septal region
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Neuroreceptor Profile and Behavior of CD-1 Mice Subpopulations with Different Attention Stability Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 G. I. Kovalev; R. M. Salimov; N. A. Sukhorukova; E. A. Kondrakhin; E. V. Vasil’eva
Abstract—We used the radioligand binding method to study the neuroreceptor profile in the brain structures of subpopulations of outbred CD-1 mice that differ in stability of attention to environmental objects in the enriched closed plus maze test. In the prefrontal cortex of the subpopulation of mice with low attention to new objects, the density (Bmax, fmol/mg of protein) of D2-dopamine receptors
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Arp2/3 Is Required for Axonal Arbor Terminal Retraction in Cerebellar Granule Neurons Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 T. Ikeno; Y. Konishi
AbstractAlthough selective pruning of subsets of branches is a key step for axonal remodeling, the underlying mechanisms have not fully elucidated. We have reported that the retraction rate of axonal arbor is higher in the terminals, where less kinesin is sorted, and inhibiting actin turnover by treatment with latrunculin A prevented retraction in such terminals. In the present study, we investigated
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Influence of Mitochondrial ATP-Sensitive Potassium Channels on Toxic Effect of Amyloid-β 25–35 Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 Lourdes A. Vega Rasgado; Arantxa Tabernero Urbieta; José María Medina Jiménez
AbstractAmyloid-β (Aβ) is the main component of senile plaques, one of the hallmarks of Alzheimer,s disease. Is been shown that Aβ25–35 decreased neuronal viability while it increased generation of reactive oxygen species (ROS), and albumin (BSA) prevented ROS production and neuronal death in a dose-and time-dependent manner. One of the major sources of ROS is mitochondrion, and is believed that Mitochondrial
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Basolateral Amygdala α1-Adrenergic Receptor Suppression Attenuates Stress-Induced Anxiety-Like Behavior and Spine Morphology Impairment on Hippocampal CA1 Pyramidal Neurons Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 Nasrin Faraji; Abdolhossein Shiravi; Zahra Bahari; Hossein Shirvani; Gholam Hossein Meftahi
AbstractThe basolateral amygdala (BLA) and hippocampus are part of the limbic fear–anxiety circuit and have also been implicated in the stress response. The BLA is rich in the expression of α1-adrenoceptors. We hypothesized that α1-adrenoceptors in BLA, may modulate stress-induced anxiety-like behavioral responses and hippocampal CA1 pyramidal neuron spine density. α1-Adrenoceptors agonist, phenylephrine
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Peculiarities of DNA and Histone H3 Methylation in the Hippocampus and Neocortex of Rats Subjected to Pathological Treatments during the Prenatal Period Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 E. I. Tyul’kova; L. A. Vataeva; V. A. Stratilov; V. S. Barysheva; O. V. Vetrovoy
Abstract—Stress during pregnancy can cause the structural and functional changes in the fetal brain, which subsequently lead to the formation of various neuropsychiatric diseases, including attention deficit hyperactivity disorder, depression, schizophrenia, autism, and others. Among the stress factors that can lead to disorders of fetal development, prenatal hypoxic stress is especially important
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Neuroprotective Activity of Docosahexaenoic Acid in the Central and Peripheral Nervous System after Chronic Constriction Injury of the Sciatic Nerve Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 I. V. Manzhulo; A. A. Tyrtyshnaia; O. S. Manzhulo; A. A. Starinets; S. P. Kasyanov; I. V. Dyuizen
Abstract—The analgesic and neuroprotective activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied in a model of rat chronic constriction injury of the sciatic nerve. We characterized the morphological and chemical state of the distal sciatic nerve segment and the activity of GFAP-positive astroglia and SP-ergic nerve fibers on the 7th and 28th day after the operation. It was found that DHA improves
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The Induction of a Depression-Like State by Chronic Exposure to Ultrasound in Rats Is Accompanied by a Reduction in Gene Expression of GABA A -Receptor Subunits in the Brain Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 A. V. Gorlova; D. A. Pavlov; V. M. Ushakova; E. A. Zubkov; Ya. A. Zorkina; A. Yu. Morozova; A. N. Inozemtsev; V. P. Chekhonin
Abstract—We studied quantitative changes in the components of GABAergic system in Sprague–Dawley rats using an ultrasound model of a depression-like state induced by chronic action of randomly alternating ultrasonic frequencies of 20–45 kHz. We measured expression of the GABRA1, GABRA2, GABRA3, and GABRB2 genes coding the α1, α2, α3, and β2 subunits of GABAA-receptors, respectively, in the hippocampus
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Dopamine Synthesis by Non-Dopaminergic Neurons in the Stratium of Mice with and without Degeneration of the Nigrostriatal Dopaminergic System Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 V. E. Blokhin; T. S. Pronina; M. V. Ugryumov
Abstract—In the past 15 years, it has been shown that dopamine (DA) is synthesized in the brain not only by dopaminergic neurons but also by non-dopaminergic neurons expressing one of the complementary enzymes tyrosine hydroxylase or aromatic L-amino acid decarboxylase (hereinafter, decarboxylase). Moreover, L-DOPA, an intermediate product of DA synthesis, is transported from neurons containing tyrosine
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Vasopressin in Relation to Selected Oxidative Stress Markers as Etiological Mechanism of Autism Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 W. A. Al-Zahrani; L. Al-Ayadhi; M. Anwar; R. S. Bhat; O. Alnakhli; N. Zayed; A. El-Ansary
AbstractThe marked heterogeneity of autism spectrum disorders is a challenge for research into biomarkers of these disorders. The present study aimed to assess the association of the thioredoxin (TRX) system and vasopressin with autism in children. Thirty-five autistic children were recruited with thirty-one healthy controls children matched for age and gender. Total antioxidant capacity (TAC), vasopressin
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Distinct Cerebellar Glycosphingolipid Phenotypes in Wistar and Lewis Rats Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 Jasminka Rešić Karara; Martin Kowalski; Anita Markotić; Tatijana Zemunik; Vedrana Čikeš Čulić
AbstractThree strains of laboratory rats (Lewis, Wistar and Sprague–Dawley) commonly used for the study of movement disorders differ in gait traits. Sialic acid containing glycosphingolipids, called gangliosides, are abundant in the nervous system, where they affect numerous neurochemical events. Cerebellum plays the key role in the integration of body movements. This study investigated glycosphingolipid
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Neurochemical and Behavioral Features of Action of Pre-Fibrillar Oligomeric Structures of α-Sinuclein in Adult Mice Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 M. A. Gruden’; O. A. Solov’eva; V. S. Kudrin; V. B. Narkevich; V. V. Sherstnev
Abstract—The pre-fibrillar oligomeric structures of the α-synuclein protein formed during misfolding play an important role in the molecular pathogenesis of Parkinson’s disease and other age-dependent neurodegenerative diseases. We studied the effect of toxic α-synuclein oligomers administered intranasally for 14 days on the motor activity, learning, memory, and anxiety of adult (6-month-old) male
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Changes in Antibodies against Nervous Tissue Proteins in Patients with Chronic Mercury Intoxication in the Post-Contact Period Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 G. M. Bodienkova; E. V. Boklazhenko
Abstract—The purpose of the study was to identify patterns of changes in the levels of antibodies (ABs) against nervous tissue regulatory proteins during the post-contact period in patients with varying degrees of neurointoxication from metallic mercury vapor. We studied dependent samples collected in a 5 year period from men with first, second or third degree chronic mercury intoxication (CMI). By
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Functional Role of Aquaporins in the Nervous System under Normal and Pathological Conditions Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 M. E. Shchepareva; M. N. Zakharova
Abstract—Aquaporins are transmembrane proteins. Their main function in the nervous system is water transport. Furthermore, some of them are capable of transporting glycerol, urea, and certain gases; they also take part in glial scar formation, astrocyte migration, and neurotransmission. Some data suggest that aquaporins are involved in the pathogenesis of brain edema and tumors, autoimmune processes
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Hemantane a Derivative of Aminoadamantane Alleviates Morphine-Induced Hyperlocomotion via Modulation of Activity of the Dopaminergic and Serotonergic Systems Neurochem. J. (IF 0.414) Pub Date : 2020-03-31 L. G. Kolik; A. V. Nadorova; V. B. Narkevich; V. S. Kudrin
Abstract—Morphine is known to induce a long-term hyperlocomotor response due to increased dopamine release in the nucleus accumbens via the activation of dopaminergic neurons in the ventral tegmental area. It has been demonstrated that the low-affinity antagonist of NMDA receptors hemantane can alleviate ethanol-induced stimulation of behavior due to its effect on the dopamine- and noradrenergic systems
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The Possible Mechanism of the Appearance of Nightmares in Post-Traumatic Stress Disorder and Approaches to Their Prevention Neurochem. J. (IF 0.414) Pub Date : 2019-12-11 I. G. Silkis
Abstract—It is hypothesized that the basis of nightmares in post-traumatic stress disorder (PTSD) is modification of synaptic transmission in neural circuits that contain one of the following structures: the visual cortex, prefrontal cortex (PfC), basolateral amygdala (BLA), hippocampus, connected with them nuclei of the thalamus and basal ganglia (BG). The emergence of dreams is promoted by the induction
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Lipid Peroxidation and the Antioxidant System in the Blood of Epileptic Patients Neurochem. J. (IF 0.414) Pub Date : 2019-12-11 N. A. Zharkinbekova; N. Zh. Ormanov
Abstract—We studied lipid peroxidation and measured the products of lipid peroxidation (LPO) together with the indices of the antioxidant system (AOS) in the blood of patients with epilepsy of various severities in the South Kazakhstan region of Kazakhstan. We examined 95 epileptic patients, including 35 patients with 3 seizure attacks per year, 30 patients with up to 12 seizure attacks per year, and
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Expression of Neurotrophic Factor 3 in the Hippocampus of Neonatal Rats after Administration of Dexamethasone Neurochem. J. (IF 0.414) Pub Date : 2019-12-11