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A female case of L1 syndrome that may have developed due to skewed X inactivation Brain Dev. (IF 1.7) Pub Date : 2024-03-12 Tatsuo Mori, Mutsuki Nakano, Takahiro Tayama, Aya Goji, Yoshihiro Toda, Shinichi Kameyama, Takeshi Mizuguchi, Maki Urushihara, Naomichi Matsumoto
Heterozygous variants cause L1 syndrome with hydrocephalus and aplasia/hypoplasia of the corpus callosum. L1 syndrome usually has an X-linked recessive inheritance pattern; however, we report a rare case occurring in a female child. The patient’s family history was unremarkable. Fetal ultrasonography revealed enlarged bilateral ventricles of the brain and hypoplasia of the corpus callosum. The patient
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Long-term efficacy of intrathecal cyclodextrin in patients with Niemann-Pick disease type C Brain Dev. (IF 1.7) Pub Date : 2024-03-06 Muneaki Matsuo, Takafumi Sakakibara, Yoshio Sakiyama, Tetsumin So, Motomichi Kosuga, Toshihiko Kakiuchi, Fumio Ichinose, Takuji Nakamura, Yoichi Ishitsuka, Tetsumi Irie
Niemann–Pick type C (NPC) is a rare lysosomal storage disease characterized by hepatosplenomegaly and progressive neurological deterioration due to abnormal intracellular cholesterol transport. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (HPBCD) is an effective treatment for NPC; however, few reports have shown its long-term efficacy and safety. To demonstrate long-term efficacy and safety
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The muscle regeneration marker FOXP3 is associated with muscle injury in Duchenne muscular dystrophy Brain Dev. (IF 1.7) Pub Date : 2024-02-22 Sthephanie Yannin Hernández-de la Cruz, Thania Ordaz-Robles, Marco Antonio Villaldama-Soriano, Cristian Emmanuel Luna-Guzmán, Tomas Almeida-Becerril, Judith Villa-Morales, Alan Cárdenas-Conejo, Eugenia Dolores Ruíz-Cruz, Jorge Maldonado-Hernandez, Mariela Bernabe-Garcia, Lourdes Barbosa-Cortés, Maricela Rodríguez-Cruz
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‘Reading the palm’ – A pilot study of grip and finger flexion strength as an outcome measure in 5q spinal muscular atrophy Brain Dev. (IF 1.7) Pub Date : 2024-02-07 Constanze Weber, Anne Müller, Maren Freigang, Maja von der Hagen, René Günther
Innovative RNA modifying and gene replacement therapies are currently revolutionizing the therapeutic landscape in 5q-associated spinal muscular atrophy (SMA). In order to provide individual recommendations for choice of treatment and therapy (dis-) continuation, objective outcome measures are needed. The purpose of this study was to determine whether maximum isometric voluntary grip and finger flexion
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Key considerations for the diagnosis of Guillain-Barré syndrome in pediatric populations Brain Dev. (IF 1.7) Pub Date : 2024-02-01 T, e, j, a, s, , C, ., , S, e, k, h, a, r
Abstract not available
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Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study Brain Dev. (IF 1.7) Pub Date : 2024-01-03 Tomoyuki Akiyama, Daisuke Saigusa, Takushi Inoue, Chiho Tokorodani, Mari Akiyama, Rie Michiue, Atsushi Mori, Eiji Hishinuma, Naomi Matsukawa, Takashi Shibata, Hiroki Tsuchiya, Katsuhiro Kobayashi
The discovery of objective indicators for recent epileptic seizures will help confirm the diagnosis of epilepsy and evaluate therapeutic effects. Past studies had shortcomings such as the inclusion of patients under treatment and those with various etiologies that could confound the analysis results significantly. We aimed to minimize such confounding effects and to explore the small molecule biomarkers
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A comprehensive study of mutation and phenotypic heterogeneity of childhood mitochondrial leukodystrophies Brain Dev. (IF 1.7) Pub Date : 2023-12-21 Sareh Hosseinpour, Ehsan Razmara, Morteza Heidari, Zahra Rezaei, Mahmoud Reza Ashrafi, Ali Zare Dehnavi, Reyhaneh Kameli, Ali Hosseini Bereshneh, Hassan Vahidnezhad, Reza Azizimalamiri, Zahra Zamani, Neda Pak, Maryam Rasulinezhad, Bahram Mohammadi, Homa Ghabeli, Mohammad Ghafouri, Mahmoud Mohammadi, Gholam Reza Zamani, Reza Shervin Badv, Sasan Saket, Bahareh Rabbani, Nejat Mahdieh, Ali Ahani, Masoud
Mitochondrial leukodystrophies (MLs) are mainly caused by impairments of the mitochondrial respiratory chains. This study reports the mutation and phenotypic spectrum of a cohort of 41 pediatric patients from 39 distinct families with MLs among 320 patients with a molecular diagnosis of leukodystrophies. This study summarizes the clinical, imaging, and molecular data of these patients for five years
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Risk factors for post-encephalopathic epilepsy in patients with acute encephalopathy with biphasic seizures and late reduced diffusion Brain Dev. (IF 1.7) Pub Date : 2023-12-19 Makoto Nishioka, Mitsuo Motobayashi, Tetsuhiro Fukuyama, Yuji Inaba
Post-encephalopathic epilepsy (PEE) is a serious complication of acute encephalopathy syndromes, and is more frequent in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) than in children with acute encephalopathy. However, a risk factor analysis using laboratory findings in the acute phase of AESD has not yet been performed. Therefore, the present study examined
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Nusinersen induces detectable changes in compound motor action potential response in spinal muscular atrophy type 1 patients with severe impairment of motor function Brain Dev. (IF 1.7) Pub Date : 2023-12-15 Yuki Ueda, Kiyoshi Egawa, Kentaro Kawamura, Noriki Ochi, Takeru Goto, Shuhei Kimura, Masashi Narugami, Sachiko Nakakubo, Midori Nakajima, Atsushi Manabe, Hideaki Shiraishi
Background Most long-term affected spinal muscular atrophy (SMA) type 1 patients have severe impairment of motor function and are dependent on mechanical ventilation with tracheostomy. The efficacy and safety of nusinersen in these patients have not been established. Methods We retrospectively evaluated the efficacy of intrathecal nusinersen treatment in patients with SMA type 1 who continued treatment
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Neuropsychiatric manifestations associated with Juvenile Systemic Lupus Erythematosus: An overview focusing on early diagnosis Brain Dev. (IF 1.7) Pub Date : 2023-12-07 Anna Nikolaidou, Ioannis Beis, Pinelopi Dragoumi, Dimitrios Zafeiriou
Juvenile systemic lupus erythematosus (jSLE) is a chronic multisystem inflammatory disease that manifests before the age of 16 years, following a remitting - relapsing course. The clinical presentation in children is multifaceted, most commonly including constitutional, hematological, cutaneous, renal, and neuropsychiatric symptoms. Neuropsychiatric manifestations range widely, affecting approximately
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New Year’s greetings Brain Dev. (IF 1.7) Pub Date : 2023-12-06 Masafumi Morimoto
Abstract not available
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In patients with neurological complications, SARS-CoV-2 infection must be confirmed by PCR Brain Dev. (IF 1.7) Pub Date : 2023-12-06 Josef Finsterer
Abstract not available
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Splicing variant of WDR37 in a case of Neurooculocardiogenitourinary syndrome Brain Dev. (IF 1.7) Pub Date : 2023-12-03 Mai Samejima, Mitsuko Nakashima, Jun Shibasaki, Hirotomo Saitsu, Mitsuhiro Kato
Background Neurooculocardiogenitourinary syndrome (NOCGUS), a multisystemic syndrome characterized by motor disorder, intellectual disability, seizures, abnormal brain structure, ocular diseases, and cardiac diseases, has been reported with missense variant of WD repeat-containing protein 37 (WDR37) in humans. This report aimed to identify the cause of NOCGUS in an affected patient. Case presentation
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Current state of hemispherectomy and callosotomy for pediatric refractory epilepsy in Denmark Brain Dev. (IF 1.7) Pub Date : 2023-12-03 Victoria Elizabeth De Knegt, Malene Landbo Børresen, Marianne Knudsen, Katrine Moe Thomsen, Peter Vilhelm Uldall, Anne Vagner Jakobsen, Christina Engel Hoei-Hansen
Objective To evaluate outcomes from hemispherectomy and callosotomy related to the need for anti-seizure medication (ASM), seizure frequency, and cognition. Methods A review of the medical charts of all Danish pediatric patients who underwent hemispherectomy or callosotomy from January 1996 to December 2019 for preoperative and postoperative ASM use, seizure frequency, and cognitive data. Results The
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The relation between neuroimaging and visual impairment in children and adolescents with cerebral palsy: A systematic review Brain Dev. (IF 1.7) Pub Date : 2023-11-27 Monica Crotti, Sarah Genoe, Nofar Ben Itzhak, Lisa Mailleux, Els Ortibus
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Efficacy of methylphenidate treatment in childhood myotonic dystrophy type 1 and comorbid attention deficit hyperactivity disorder: A case report using eye tracking assessment Brain Dev. (IF 1.7) Pub Date : 2023-11-25 Dirk J.J. Sweere, Jos G.M. Hendriksen, R. Jeroen Vermeulen, Sylvia Klinkenberg
Introduction Despite the increased prevalence of comorbid attention deficit hyperactivity disorder (ADHD) in children with myotonic dystrophy type 1, the effects of methylphenidate treatment on associated cognitive deficits in this population is not yet investigated. Case: We describe a case study of an eleven-year-old male patient with myotonic dystrophy type 1 and comorbid ADHD that was treated with
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Corrigendum to “Dramatic effect of levetiracetam in early-onset epileptic encephalopathy due to STXBP1 mutation” [Brain Dev. 38(1) (2016) 128–131] Brain Dev. (IF 1.7) Pub Date : 2023-11-25 Robertino Dilena, Pasquale Striano, Monica Traverso, Maurizio Viri, Gloria Cristofori, Laura Tadini, Sergio Barbieri, Antonino Romeo, Federico Zara
Abstract not available
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Etiologies and clinical characteristics of acute ataxia in a single national children's medical center Brain Dev. (IF 1.7) Pub Date : 2023-11-23 Min Zhang, Gang Pan, Shuizhen Zhou, Jin Shen, Wenhui Li, Yuanfeng Zhou, Lifei Yu, Linmei Zhang
Objective To analyze etiologic factors of pediatric acute ataxia and to identify the severity of its underlying causes for urgent medical intervention. Methods Clinical data of children diagnosed with acute ataxia between December 2015 and December 2021 from one national medical center were analyzed retrospectively. Results A total of 99 children (59 boys, 40 girls), median age at disease onset 55
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Early infantile spontaneous movement in very low birthweight infants is associated with sensory characteristics at the corrected age of 3 years Brain Dev. (IF 1.7) Pub Date : 2023-11-17 Osamu KOBAYASHI, Tomoki MAEDA, Kenji IHARA
Aim To clarify the relationship between early infantile spontaneous movement of very-low-birth-weight infants (VLBWIs) and sensory characteristics in childhood. Study design Prospective cohort study. We investigated the association between the Motor Optimality Score-Revised (MOS-R), a detailed assessment of general movements (GMs) at the corrected age of 9–17 weeks and the Infant/Toddler Sensory Profile
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RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3β pathway upregulation Brain Dev. (IF 1.7) Pub Date : 2023-11-17 Hai Xu, Xuetao Yu, Rong Xie, Yangyang Wang, Chunli Li
Background RE1 Silencing Transcription factor (REST) corepressor 1 (RCOR1) has been reported to orchestrate neurogenesis, while its role in cerebral palsy (CP) remains elusive. Besides, RCOR1 can interact with Endothelin-1 (EDN1), and EDN1 expression is related to brain damage. Therefore, this study aimed to explore the effects of RCOR1/EDN1 on brain damage during the progression of CP. Methods CP
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Diagnostic odyssey of Guillain-Barré syndrome in children Brain Dev. (IF 1.7) Pub Date : 2023-10-31 Yoko Kobayashi Takahashi, Itaru Hayakawa, Yuichi Abe
Background and Objectives A gap exists between difficulty in diagnosis and importance of early recognition and intervention in pediatric Guillain-Barré syndrome (GBS). Therefore, this study aimed to establish a diagnostic odyssey plot that allows “at-a-glance” overview of the diagnostic odyssey of GBS in children, including overall diagnostic delay, physician-related and patient-related diagnostic
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Use of lacosamide for focal epilepsy in a child with kidney failure undergoing peritoneal dialysis Brain Dev. (IF 1.7) Pub Date : 2023-10-31 Yuki Ueda, Ayako Furugen, Masaki Kobayashi, Yasuyuki Sato, Yasuhiro Ueda, Asako Hayashi, Takeru Goto, Shuhei Kimura, Masashi Narugami, Sachiko Nakakubo, Midori Nakajima, Kiyoshi Egawa, Takayuki Okamoto, Atsushi Manabe, Hideaki Shiraishi
Background Lacosamide (LCM) has become commonly used for focal onset seizures due to its high tolerability and low drug interactions. Unlike patients on hemodialysis (HD), pharmacokinetic data and dosing recommendations for patients undergoing peritoneal dialysis (PD) are scant. Case report A 2-year-old girl with end-stage kidney disease undergoing PD suffered prolonged focal onset seizures. The patient
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A nationwide survey of adenovirus-associated encephalitis/encephalopathy in Japan Brain Dev. (IF 1.7) Pub Date : 2023-10-24 Mika Nakazawa, Shinpei Abe, Mitsuru Ikeno, Taiki Shima, Akihisa Okumura
Background Adenovirus is a major pathogen causing febrile illness among children. It may also cause acute encephalitis/encephalopathy. This study aimed to elucidate the clinical features of adenovirus-associated encephalitis/encephalopathy (AdVE) among children in Japan. Methods A nationwide survey of children with AdVE was conducted. An initial survey was distributed among pediatricians to obtain
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Potential of arterial spin labeling in elucidating the pathogenesis of the splenium of the corpus callosum and cerebellar dentate nucleus in encephalopathy Brain Dev. (IF 1.7) Pub Date : 2023-10-21 Masazumi Matsuda, Toshiki Murata, Takahiro Otani, Kenji Yoshida, Yui Sanpei, Katsunori Iijima, Hajime Nakae, Naoko Mori
Abstract not available
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Volumetric magnetic resonance imaging differences between complex febrile seizure and recurrent simple febrile seizure Brain Dev. (IF 1.7) Pub Date : 2023-10-07 Berrin Cavusoglu, Çigdem Ozer Gokaslan, Dilek Cavusoglu
Purpose We investigated the volumetric differences in cortical and subcortical structures between patients with complex febrile seizure (FS) and recurrent simple FS. We aimed to identify the brain morphological patterns of children with complex FS. Methods Twenty-five patients with complex FS and age- and sex-matched 25 patients with recurrent simple FS with structural magnetic resonance imaging (MRI)
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Progress in the treatment of neonatal hypoxic-ischemic encephalopathy with umbilical cord blood mononuclear cells Brain Dev. (IF 1.7) Pub Date : 2023-10-06 Jiayu Zhou, Ting Gao, Wan Tang, Tianyang Qian, Ziming Wang, Pu Xu, Laishuan Wang
Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease among newborns, which is a leading cause of neonatal death and permanent neurological sequelae. Therapeutic hypothermia (TH) is the only method for the treatment of HIE that has been recognized effective clinically at home and abroad, but the efficacy is limited. Recent research suggests that the cord blood-derived mononuclear cells
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Cilostazol treats transient heart failure caused by ATP1A3 variant-associated polymicrogyria Brain Dev. (IF 1.7) Pub Date : 2023-09-29 Naohiro Yamamoto, Ichiro Kuki, Kazuki Shimizu, Ayako Ohgitani, Naoki Yamada, Mitsuhiro Fujino, Sayaka Yoshida
Background Some patients with ATP1A3 variant-associated polymicrogyria have recurrent transient heart failure. However, effective treatment for the transient cardiac condition remains to be elucidated. Case report The patient started experiencing focal motor onset seizures in 12 h after birth, revealing bilateral diffuse polymicrogyria. The patient also experienced transient bradycardia (sinus bradycardia)
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The first case of hemorrhagic shock and encephalopathy syndrome with fulminant hypercytokinemia associated with pediatric COVID-19 Brain Dev. (IF 1.7) Pub Date : 2023-09-18 Koyuru Kurane, Keizo Wakae, Hirokazu Yamagishi, Yuta Kawahara, Marika Ono, Daisuke Tamura, Kaito Furuya, Naoyuki Taga, Mitsuru Matsuki, Takanori Yamagata, Kazuhiro Muramatsu
Background Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead not only to respiratory symptoms but also to neurologic symptoms with various levels of severity. After the worldwide prevalence of Omicron variant, severe neurological manifestations of coronavirus disease 2019 (COVID-19) such as febrile seizure, demyelinating disease, and cerebrovascular disease, have been
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Second nationwide survey of bilirubin encephalopathy in preterm infants in Japan Brain Dev. (IF 1.7) Pub Date : 2023-09-09 Akihisa Okumura, Ichiro Morioka, Hiroshi Arai, Masahiro Hayakawa, Yoshihiro Maruo, Takashi Kusaka, Tetsuya Kunikata, Sota Iwatani
Objectives To determine the clinical features of bilirubin encephalopathy in preterm infants (pBE) in Japan. Methods We performed a retrospective, nationwide questionnaire-based survey. The initial survey determined the number of children with pBE who were born after 2000. Using a structured questionnaire, the second survey clarified the clinical manifestations and characteristics of children with
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Febrile seizure in children with COVID-19 during the Omicron variant-predominant era: A single-center study Brain Dev. (IF 1.7) Pub Date : 2023-09-01 Kento Ohta, Tohru Okanishi, Yuto Arai, Sotaro Kanai, Yuko Nakamura, Noriyuki Namba, Yoshihiro Maegaki
Objective Coronavirus disease 2019 (COVID-19) has significantly impacted medical services worldwide. During the Omicron variant-predominant era, febrile seizure (FS) in patients with COVID-19 increased compared to that in the pre-Omicron variant era. Therefore, this study aimed to demonstrate the clinical characteristics of FS in patients with COVID-19. Methods We surveyed patients aged < 16 years
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Improvement in a post-stroke pediatric patient with hemiplegia: Use of a hand-arm bimanual intensive therapy with hybrid assistive limb Brain Dev. (IF 1.7) Pub Date : 2023-08-30 Yoko Matsumoto, Yuji Yoshii, Akiyo Ikutomo, Mariko Yagi, Mio Nishimura, Yoko Kawasaki, Amanda Sarafian, Heakyung Kim, David P. Roye, Hiroko Matsumoto
Background Pediatric stroke is a rare medical condition that often leads to long-lasting motor and cognitive impairments. Although therapies for adults after a stroke are well described, treatments for motor deficits following a pediatric stroke are yet to be investigated. We report a case of pediatric stroke in the chronic phase, in which a combination of novel treatments resulted in a significant
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Transcutaneous auricular vagus nerve stimulation therapy in patients with cognitively preserved structural focal epilepsy: A case series report Brain Dev. (IF 1.7) Pub Date : 2023-08-30 Hideaki Shiraishi, Kiyoshi Egawa, Kaoru Murakami, Midori Nakajima, Yuki Ueda, Sachiko Nakakubo, Masashi Narugami, Shuhei Kimura, Takeru Goto, Yasuyoshi Hiramatsu, Masaaki Murakami
Objective Transcutaneous auricular vagus nerve stimulation (taVNS) was performed in two patients suffering structural focal epilepsy with preserved intellectual ability to show the feasibility of taVNS for specific patient groups. Case Presentations Patient 1 was a 24-year-old woman with frontal lobe epilepsy who had weekly hyperkinetic seizures despite multiple anti-seizure medications. Patient 2
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Later efficacy of nusinersen treatment in adult patients with spinal muscular atrophy: A retrospective case study with a median 4-year follow-up Brain Dev. (IF 1.7) Pub Date : 2023-08-30 Michinori Funato, Atsunari Kino, Reina Iwata, Misaki Yumioka, Kohei Yamashita, Chika Urui, Ryoya Uno, Emi Kondo, Etsuko Morioka, Yoko Ogawa, Akihisa Kawamura, Toshifumi Kusukawa, Hiroshi Minatsu
Background Spinal muscular atrophy (SMA) is a hereditary neuromuscular disorder characterized by skeletal muscle atrophy and weakness. New treatments for SMA have been developed namely, the drugs nusinersen, onasemnogene abeparvovec, and risdiplam. However, there are limited reports on their effects on adult patients with SMA, particularly over long periods. Therefore, this study aimed to determine
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Severe and rare neurological manifestations following COVID-19 infection in children: A Malaysian tertiary centre experience Brain Dev. (IF 1.7) Pub Date : 2023-08-29 Muhamad Azamin Anuar, Jun Xiong Lee, Husna Musa, Dianah Abd Hadi, Elyssa Majawit, Poorani Anandakrishnan, Sumitha Murugesu, Ahmad Rithauddin Mohamed, Teik Beng Khoo
Introduction Since the emergence of COVID-19, we have experienced potent variants and sub-variants of the virus with non-specific neurological manifestations. We observed a surge of the Omicron variant of COVID-19 patients with neurological manifestations where less cases of multisystem inflammatory syndrome in children (MIS-C) were reported. This article describes our experience of children with severe
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The gaze characteristics in preterm children: The appropriate timing for an eye-tracking tool Brain Dev. (IF 1.7) Pub Date : 2023-08-28 Soichi Yamase, Wakako Ishii, Nobuhiko Nagano, Aya Okahashi, Kimiko Deguchi, Emiko Momoki, Ichiro Morioka
Background An objective screening tool for autism spectrum disorder (ASD), also known as an eye-tracking tool, assesses the patient’s abnormal gaze patterns and detects the risk of ASD. As this tool is generally used for children born at term, this study aimed to clarify the appropriate timing for using the tool for preterm children, factors that influence the timing, and evaluate their gaze characteristics
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Survey of medications for myelomeningocele patients over their lifetime in Japan Brain Dev. (IF 1.7) Pub Date : 2023-08-26 Haruna Isozaki, Masahiro Nonaka, Yumiko Komori, Katsuya Ueno, Haruka Iwamura, Mayuko Miyata, Natsumi Yamamura, Yi Li, Junichi Takeda, Yuichiro Nonaka, Ichiro Yabe, Masayoshi Zaitsu, Kenji Nakashima, Akio Asai
Background This study aimed to investigate medication prescriptions for patients with myelomeningocele (MMC) across different age groups, particularly in adulthood and after middle age. Methods The Japan Medical Data Center (JMDC) database, based on medical claims data, was utilized for this analysis. Patients were divided into 10-year age groups, and prescriptions for analgesics, anticonvulsants,
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ATP6V1B2-related disorders featuring Lennox-Gastaut-syndrome: A case-based overview Brain Dev. (IF 1.7) Pub Date : 2023-08-25 Greta Amore, Elisa Calì, Maria Spanò, Giorgia Ceravolo, Giuseppe Donato Mangano, Giovanna Scorrano, Stephanie Efthymiou, Vincenzo Salpietro, Henry Houlden, Gabriella Di Rosa
Background ATP6V1B2 (ATPase, H+ transporting, lysosomal VI subunit B, isoform 2) encodes for a subunit of a ubiquitous transmembrane lysosomal proton pump, implicated in the acidification of intracellular organelles and in several additional cellular functions. Variants in ATP6V1B2 have been related to a heterogeneous group of multisystemic disorders sometimes associated with variable neurological
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Call For Abstracts For Oral And Poster Presentations The International Session Brain Dev. (IF 1.7) Pub Date : 2023-08-24
Abstract not available
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A boy with a progressive neurologic decline harboring two coexisting mutations in KMT2D and VPS13D Brain Dev. (IF 1.7) Pub Date : 2023-08-18 Yu-Ming Chang, Yu-Wen Pan, Yen-Yin Chou, Wen-Hao Yu, Meng-Che Tsai
Introduction Kabuki syndrome (KS) and spinocerebellar ataxia (SCA) are both rare conditions with neurodevelopmental abnormalities. Approaching a patient with complex phenotypes and differentiating the role of mutations may be beneficial but challenging in predicting the disease prognosis. Case presentation A boy presented with progressive ataxia, developmental regression, and myoclonus since 4 years
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Call For Abstracts For Oral And Poster Presentations The International Session Brain Dev. (IF 1.7) Pub Date : 2023-08-08
Abstract not available
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Usefulness of arterial spin labeling imaging, which contributed to the early detection of cerebellitis complicated by clinically mild encephalitis/encephalopathy with a reversible splenial lesion: Lessons from three cases Brain Dev. (IF 1.7) Pub Date : 2023-08-08 Nanako Nishiguchi, Tatsuharu Sato, Kazuhiko Hashimoto, Takuya Hayashida, Kouhei Haraguchi, Reiko Ideguchi, Hiroyuki Moriuchi
Background Cerebellitis is a rare complication of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS); however, MERS with cerebellitis is associated with a higher risk of neurological sequelae in comparison to MERS alone. Although the disease is difficult to diagnose by conventional MRI in the early disease phase, arterial spin labeling (ASL), a noninvasive MRI perfusion