-
A Simplified Method for the Histochemical Detection of Iron in Paraffin Sections: Intracellular Iron Deposits in Central Nervous System Tissue ASN Neuro (IF 4.167) Pub Date : 2021-01-11 Steven M. LeVine; Hao Zhu; Sarah E. Tague
Although all cells contain iron, most histochemical methods fail to reveal the presence of iron within many cells of the central nervous system (CNS), particularly neurons. Previously, a sensitive method was developed that limited the extraction of iron in paraffin sections, and this method revealed staining within neurons. However, the staining was often too robust making it difficult to discern discrete
-
Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock ASN Neuro (IF 4.167) Pub Date : 2021-01-11 Santiago Andrés Plano; María Soledad Alessandro; Laura Lucía Trebucq; Shogo Endo; Diego Andrés Golombek; Juan José Chiesa
The mammalian circadian clock at the hypothalamic suprachiasmatic nuclei (SCN) entrains biological rhythms to the 24-h cyclic environment, by encoding light-dark transitions in SCN neurons. Light pulses induce phase shifts in the clock and in circadian rhythms; photic signaling for circadian phase advances involves a nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase
-
Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder ASN Neuro (IF 4.167) Pub Date : 2020-12-20 Arman Fesharaki-Zadeh; Jeremy T. Miyauchi; Karrah St. Laurent-Arriot; Stella E. Tsirka; Peter J. Bergold
Comorbid post-traumatic stress disorder with traumatic brain injury (TBI) produce more severe affective and cognitive deficits than PTSD or TBI alone. Both PTSD and TBI produce long-lasting neuroinflammation, which may be a key underlying mechanism of the deficits observed in co-morbid TBI/PTSD. We developed a model of co-morbid TBI/PTSD by combining the closed head (CHI) model of TBI with the chronic
-
Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation ASN Neuro (IF 4.167) Pub Date : 2020-12-20 Rashmi Das; Abhishek Ankur Balmik; Subashchandrabose Chinnathambi
Alzheimer’s disease is a neuropathological condition with abnormal accumulation of extracellular Amyloid-β plaques and intracellular neurofibrillary tangles of Microtubule-associated protein Tau (Tau) in the brain. In pathological conditions, Tau undergoes post-translational modifications such as hyperphosphorylation by the activity of cellular kinases, which eventually leads to protein aggregation
-
Erratum to “Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4” ASN Neuro (IF 4.167) Pub Date : 2020-12-13
Walch, E., Murphy, T. R., Cuvelier, N., Aldoghmi, M., Morozova, C., Donohue, J., Young, G., Samant, A., Garcia, S., Alvarez, C., Bilas, A., Davila, D., Binder, D. K., & Fiacco, T. A. (2020). Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4. ASN Neuro. https://doi.org/10.1177/1759091420967152
-
Astrocyte Glutamate Uptake and Water Homeostasis Are Dysregulated in the Hippocampus of Multiple Sclerosis Patients With Seizures ASN Neuro (IF 4.167) Pub Date : 2020-12-09 Andrew S. Lapato; Sarah M. Thompson; Karen Parra; Seema K. Tiwari-Woodruff
While seizure disorders are more prevalent among multiple sclerosis (MS) patients than the population overall and prognosticate earlier death & disability, their etiology remains unclear. Translational data indicate perturbed expression of astrocytic molecules contributing to homeostatic neuronal excitability, including water channels (AQP4) and synaptic glutamate transporters (EAAT2), in a mouse model
-
Merits and Limitations of Studying Neuronal Depolarization-Dependent Processes Using Elevated External Potassium ASN Neuro (IF 4.167) Pub Date : 2020-11-30 Kira D. A. Rienecker; Robert G. Poston; Ramendra N. Saha
Elevated extracellular potassium chloride is widely used to achieve membrane depolarization of cultured neurons. This technique has illuminated mechanisms of calcium influx through L-type voltage sensitive calcium channels, activity-regulated signaling, downstream transcriptional events, and many other intracellular responses to depolarization. However, there is enormous variability in these treatments
-
Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis ASN Neuro (IF 4.167) Pub Date : 2020-11-23 Marisa A. Jeffries; Alison E. Obr; Kelly Urbanek; Sharyl L. Fyffe-Maricich; Teresa L. Wood
The ERK1/2 signaling pathway promotes myelin wrapping during development and remyelination, and sustained ERK1/2 activation in the oligodendrocyte (OL) lineage results in hypermyelination of the CNS. We therefore hypothesized that increased ERK1/2 signaling in the OL lineage would 1) protect against immune-mediated demyelination due to increased baseline myelin thickness and/or 2) promote enhanced
-
Norepinephrine Regulation of Adrenergic Receptor Expression, 5’ AMP-Activated Protein Kinase Activity, and Glycogen Metabolism and Mass in Male Versus Female Hypothalamic Primary Astrocyte Cultures ASN Neuro (IF 4.167) Pub Date : 2020-11-11 Mostafa M. H. Ibrahim; Khaggeswar Bheemanapally; Paul W. Sylvester; Karen P. Briski
Norepinephrine (NE) control of hypothalamic gluco-regulation involves astrocyte-derived energy fuel supply. In male rats, exogenous NE regulates astrocyte glycogen metabolic enzyme expression in vivo through 5’-AMP-activated protein kinase (AMPK)-dependent mechanisms. Current research utilized a rat hypothalamic astrocyte primary culture model to investigate the premise that NE imposes sex-specific
-
Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na+/K+ ATPase and Occurs Independently of Aquaporin 4 ASN Neuro (IF 4.167) Pub Date : 2020-10-22 Erin Walch; Thomas R. Murphy; Nicholas Cuvelier; Murad Aldoghmi; Cristine Morozova; Jordan Donohue; Gaby Young; Anuja Samant; Stacy Garcia; Camila Alvarez; Alex Bilas; David Davila; Devin K. Binder; Todd A. Fiacco
Astrocytes and neurons have been shown to swell across a variety of different conditions, including increases in extracellular potassium concentration (^[K+]o). The mechanisms involved in the coupling of K+ influx to water movement into cells leading to cell swelling are not well understood and remain controversial. Here, we set out to determine the effects of ^[K+]o on rapid volume responses of hippocampal
-
History of Neuroscience I. Pío del Río-Hortega (1882–1945): The Discoverer of Microglia and Oligodendroglia ASN Neuro (IF 4.167) Pub Date : 2020-10-18 Anne I. Boullerne; Douglas L. Feinstein
When we think about the history of glial cells, Santiago Ramón y Cajal comes to mind, who in addition to receiving the Nobel Prize in 1906 for staining individual neurons, is also credited with being the first to be able to specifically stain astroglia (Cajal, 1913a). However, Cajal (1913b) was initially unable to stain a third set of small cells present in tissue sections which apparently did not
-
Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination ASN Neuro (IF 4.167) Pub Date : 2020-09-30 Veronica T. Cheli; J. Correale; Pablo M. Paez; Juana M. Pasquini
Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Oligodendrocytes and astrocytes are crucial players in brain iron equilibrium. However, the mechanisms of iron uptake, storage, and efflux in oligodendrocytes and astrocytes during CNS development or under pathological situations
-
Substantia Nigra Abnormalities Provide New Insight on the Neural Mechanisms Underlying the Sleep-Arousal Phase Dysfunctions in Sudden Infant Death Syndrome ASN Neuro (IF 4.167) Pub Date : 2020-09-30 Anna M. Lavezzi; Riffat Mehboob; Graziella Alfonsi; Stefano Ferrero
The purpose of this study was to research possible developmental alterations of the substantia nigra (SN) in sudden infant death syndrome (SIDS), a syndrome frequently attributed to arousal failure from sleep. Brain stems of 46 victims of sudden infant death, aged from 1 to about 7 months (4 to 30 postnatal weeks), were investigated. Twenty-six of these cases were diagnosed as SIDS, due to the lack
-
Alleviation of Cerebral Infarction of Rats With Middle Cerebral Artery Occlusion by Inhibition of Aquaporin 4 in the Supraoptic Nucleus ASN Neuro (IF 4.167) Pub Date : 2020-09-26 Dan Cui; Shuwei Jia; Jiawei Yu; Dongyang Li; Tong Li; Yang Liu; Jinlong Chang; Xiaoran Wang; Xiaoyu Liu; Yu-Feng Wang
In ischemic stroke, vasopressin hypersecretion is a critical factor of cerebral swelling and brain injury. To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle cerebral artery occlusion (MCAO) in rats on astrocytic plasticity and vasopressin neuronal activity in the supraoptic nucleus (SON) as well as their
-
Striatal Acetylcholine Helps to Preserve Functional Outcomes in a Mouse Model of Stroke. ASN Neuro (IF 4.167) Pub Date : 2020-09-23 Daniela F Goncalves,Monica S Guzman,Robert Gros,André R Massensini,Robert Bartha,Vania F Prado,Marco A M Prado
Acetylcholine (ACh) has been suggested to facilitate plasticity and improve functional recovery after different types of brain lesions. Interestingly, numerous studies have shown that striatal cholinergic interneurons are relatively resistant to acute ischemic insults, but whether ACh released by these neurons enhances functional recovery after stroke is unknown. We investigated the role of endogenous
-
Involvement of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 in Oxytocin Neuronal Activity in Lactating Rats With Pup Deprivation. ASN Neuro (IF 4.167) Pub Date : 2020-09-22 Dongyang Li,Haitao Liu,Xiaoyu Liu,Hongyang Wang,Tong Li,Xiaoran Wang,Shuwei Jia,Ping Wang,Yu-Feng Wang
Oxytocin, a hypothalamic neuropeptide essential for breastfeeding, is mainly produced in oxytocin neurons in the supraoptic nucleus (SON) and paraventricular nucleus. However, mechanisms underlying oxytocin secretion, specifically the involvement of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) in oxytocin neuronal activity, remain unclear. Using a rat model of intermittent and
-
Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion. ASN Neuro (IF 4.167) Pub Date : 2020-09-14 Yangyang Huang,Yeri J Song,Maria Isaac,Shir Miretzky,Ashish Patel,W Geoffrey McAuliffe,Cheryl F Dreyfus
The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater losses in myelin protein levels compared to wild-type mice after cuprizone. To investigate whether OLGs may directly mediate these effects of BDNF
-
Severe Acute Respiratory Syndrome Coronavirus 2 Impact on the Central Nervous System: Are Astrocytes and Microglia Main Players or Merely Bystanders? ASN Neuro (IF 4.167) Pub Date : 2020-09-02 Veronica Murta,Alejandro Villarreal,Alberto J Ramos
With confirmed coronavirus disease 2019 (COVID-19) cases surpassing the 18 million mark around the globe, there is an imperative need to gain comprehensive understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are associated with respiratory or intestinal symptoms, reports of neurological signs and symptoms are increasing
-
GFAP at 50. ASN Neuro (IF 4.167) Pub Date : 2020-08-18 Albee Messing,Michael Brenner
Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse as structural biology, cell biology, gene expression, basic neuroscience, clinical genetics and gene therapy. This review covers each of these areas, presenting
-
Enhanced Susceptibility to Chemoconvulsant-Induced Seizures in Ganglioside GM3 Synthase Knockout Mice. ASN Neuro (IF 4.167) Pub Date : 2020-07-14 Fu-Lei Tang,Jing Wang,Yukata Itokazu,Robert K Yu
Ganglioside GM3 synthase (α-2,3-sialyltransferase, ST3GAL5, GM3S) is a key enzyme involved in the biosynthesis of gangliosides. ST3GAL5 deficiency causes an absence of GM3 and all downstream biosynthetic derivatives. The affected individuals manifest deafness, severe irritability, intractable seizures, and profound intellectual disability. To investigate whether deficiency of GM3 is involved in seizure
-
Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice. ASN Neuro (IF 4.167) Pub Date : 2020-06-03 Laura E Montroull,Deborah E Rothbard,Hur D Kanal,Veera D'Mello,Vincent Dodson,Carol M Troy,Juan P Zanin,Steven W Levison,Wilma J Friedman
The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, with only a few neuronal subpopulations retaining expression into adulthood. However, p75NTR expression is induced following damage to the adult brain, including
-
Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved? ASN Neuro (IF 4.167) Pub Date : 2020-05-28 Macarena L Herrera,Romina Deza-Ponzio,Marisa S Ghersi,Emilce A de la Villarmois,Miriam B Virgolini,Mariela F Pérez,Victor A Molina,María J Bellini,Claudia B Hereñú
Cognitive dysfunction is one of the most severe nonmotor symptoms of nigrostriatal impairment. This occurs as a result of profound functional and morphological changes of different neuronal circuits, including modifications in the plasticity and architecture of hippocampal synapses. Such alterations can be implicated in the genesis and progression of dementia associated with neurodegenerative diseases
-
Shedding Light on the Dark Side of the Microglia. ASN Neuro (IF 4.167) Pub Date : 2020-05-22 Marie-Kim St-Pierre,Eva Šimončičová,Eszter Bögi,Marie-Ève Tremblay
Microglia, the resident immune cells of the central nervous system, are not a homogeneous population; their morphology, molecular profile, and even their ultrastructure greatly vary from one cell to another. Recent advances in the field of neuroimmunology have helped to demystify the enigma that currently surrounds microglial heterogeneity. Indeed, numerous microglial subtypes have been discovered
-
Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease. ASN Neuro (IF 4.167) Pub Date : 2020-05-18 Naomi K Giesers,Oliver Wirths
The deposition of amyloid-β peptides in the form of extracellular plaques and neuronal degeneration belong to the hallmark features of Alzheimer's disease (AD). In addition, impaired calcium homeostasis and altered levels in calcium-binding proteins seem to be associated with the disease process. In this study, calretinin- (CR) and parvalbumin- (PV) positive gamma-aminobutyric acid-producing (GABAergic)
-
Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus. ASN Neuro (IF 4.167) Pub Date : 2020-05-18 Lin Zhu,Shujuan Dai,Di Lu,Puying Xu,Lu Chen,Yanbing Han,Lianmei Zhong,Lvhua Chang,Qian Wu
Nuclear-distribution element-like 1 (NDEL1) is associated with the proliferation and migration of neurons. Vascular endothelial growth factor (VEGF) in combination with VEGF receptor-2 (VEGFR-2) regulates the proliferation and migration of neurons. This study was performed to explore undefined alterations in the expression levels of NDEL1 and VEGF/VEGFR-2 within the hippocampus after status epilepticus
-
Diffusion Tensor Imaging Detects Acute and Subacute Changes in Corpus Callosum in Blast-Induced Traumatic Brain Injury. ASN Neuro (IF 4.167) Pub Date : 2020-05-13 Palamadai N Venkatasubramanian,Prachi Keni,Roland Gastfield,Limin Li,Daniil Aksenov,Sydney A Sherman,Julian Bailes,Brian Sindelar,John D Finan,John Lee,Julian E Bailes,Alice M Wyrwicz
There is a critical need for understanding the progression of neuropathology in blast-induced traumatic brain injury using valid animal models to develop diagnostic approaches. In the present study, we used diffusion imaging and magnetic resonance (MR) morphometry to characterize axonal injury in white matter structures of the rat brain following a blast applied via blast tube to one side of the brain
-
Alzheimer Drug Trials: Combination of Safe and Efficacious Biologicals to Break the Amyloidosis-Neuroinflammation Vicious Cycle. ASN Neuro (IF 4.167) Pub Date : 2020-04-14 Tamas Bartfai,Graham V Lees
Late-onset Alzheimer’s disease (LOAD) is a long-enduring neurodegenerative disease (Jack et al., 2018) that progresses for decades before the symptoms of cognitive decline and loss of executive function are measurable.
-
Unbiased Proteomic Approach Identifies Pathobiological Profiles in the Brains of Preclinical Models of Repetitive Mild Traumatic Brain Injury, Tauopathy, and Amyloidosis ASN Neuro (IF 4.167) Pub Date : 2020-04-02 Joseph O. Ojo; Gogce Crynen; Moustafa Algamal; Prashanti Vallabhaneni; Paige Leary; Benoit Mouzon; Jon M. Reed; Michael Mullan; Fiona Crawford
Mild traumatic brain injury (mTBI) is the most common (>80% cases) type of TBI within the military and civilian populations and is a major cause of disability and functional impairment. Epidemiological studies have reported that individuals exposed to a history of TBI are more susceptible to developing sporadic age-related neurodegenerative conditions in later life (Gedye et al., 1989; Mortimer et al
-
Estrogen Receptor Involvement in Noradrenergic Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neurotransmitter and Stimulus-Specific Glycogen Phosphorylase Enzyme Isoform Expression. ASN Neuro (IF 4.167) Pub Date : 2020-03-31 A S M H Mahmood,Prabhat R Napit,Md Haider Ali,Karen P Briski
The ventromedial hypothalamic nucleus (VMN) integrates nutrient and other cues to control glucostasis (Watts and Donovan, 2010; Donovan and Watts, 2014). VMN metabolic-sensory neurons adjust synaptic firing to supply a dynamic readout of neuroenergetic state (Oomura et al., 1969; Ashford et al., 1990; Silver and Erecińska, 1998). Characterized effector transmitters of energy insufficiency within the
-
VISSA-PLS-DA-Based Metabolomics Reveals a Multitargeted Mechanism of Traditional Chinese Medicine for Traumatic Brain Injury ASN Neuro (IF 4.167) Pub Date : 2020-03-08 Zian Xia; Wenbin Liu; Fei Zheng; Wei Huang; Zhihua Xing; Weijun Peng; Tao Tang; Jiekun Luo; Lunzhao Yi; Yang Wang
Traumatic brain injury (TBI) is known as a “silent epidemic” (Simon et al., 2017). Annually, approximately 54 to 60 million people suffer from TBI worldwide (Bazarian et al., 2018). Survivors of TBI commonly live with neurocognitive deficits and physical disability and increased risk of neurodegenerative disease in the long term (Pattinson and Gill, 2018). Unfortunately, no drug has been approved in
-
Spatiotemporal Distribution of Microglia After Traumatic Brain Injury in Male Mice ASN Neuro (IF 4.167) Pub Date : 2020-03-08 Henry W. Caplan; Fanni Cardenas; Franciska Gudenkauf; Pamela Zelnick; Hasen Xue; Charles S. Cox; Supinder S. Bedi
Traumatic brain injury (TBI) affects more than 1.5 million people in the United States each year with a mortality rate near or above 50,000 per year (Coronado et al., 2011; Thurman et al., 1999). TBI causes a prolonged secondary inflammatory response within the central nervous system (CNS) that leads to neurological deficits, both motor and cognitive, beyond that caused by the primary injury (Ramlackhansingh
-
NRF2 as a Therapeutic Target in Neurodegenerative Diseases. ASN Neuro (IF 4.167) Pub Date : 2020-01-21 Mikah S Brandes,Nora E Gray
Reactive oxygen species (ROS) serve as critical intracellular signaling molecules but in excess can cause oxidative stress and damage organelles and macromolecules, eventually leading to cell death (Zuo et al., 2015). Increased ROS production and oxidative stress have been implicated in the pathogenesis of numerous neurodegenerative conditions, including, among others, Alzheimer’s disease (AD; Behl
-
Physical Activity and Cognitive Function in Mild Cognitive Impairment. ASN Neuro (IF 4.167) Pub Date : 2020-01-16 Ya-Ting Chang
Physical exercise has been associated with enhanced memory formation and consolidation (Fernandes et al., 2016). With regard to individuals with mild cognitive impairment (MCI), two review articles reveal inconclusive results with regard to beneficial effects of exercise on cognitive function (Gates et al., 2013; Ohman et al., 2014), while other two meta-analysis studies show aerobic exercise significantly
-
Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells. ASN Neuro (IF 4.167) Pub Date : 2019-12-11 Paula M Wagner,Natalia M Monjes,Mario E Guido
Carcinogenesis is a complex and multi-etiological process resulting in the accumulation of genetic alterations primarily in genes involved in the regulation of signaling pathways relevant to the control of cell growth and division (reviewed in Hanahan and Weinberg, 2011). Neoplastic processes include a number of typical characteristics such as sustained proliferative activation, growth suppressor evasion
-
Abnormalities in the Motor Unit of a Fast-Twitch Lower Limb Skeletal Muscle in Huntington's Disease. ASN Neuro (IF 4.167) Pub Date : 2019-12-10 Priscila Aparecida Costa Valadão,Bárbara Campos de Aragão,Jéssica Neves Andrade,Matheus Proença S Magalhães-Gomes,Giselle Foureaux,Julliane Vasconcelos Joviano-Santos,José Carlos Nogueira,Thatiane Cristina Gonçalves Machado,Itamar Couto Guedes de Jesus,Julia Meireles Nogueira,Rayan Silva de Paula,Luisa Peixoto,Fabíola Mara Ribeiro,Juan Carlos Tapia,ÉriKa Cristina Jorge,Silvia Guatimosim,Cristina Guatimosim
Skeletal muscle loss and dysfunction are found in Huntington’s disease (HD), which is a progressive neurodegenerative disorder caused by an autosomal dominant condition leading to motor, cognitive, and psychiatric impairment. In 1993, the Huntington’s Disease Collaborative Research Group identified a mutation in the short arm of Chromosome 4, an unstable expansion in the number of CAG repeats in the
-
Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer's Disease. ASN Neuro (IF 4.167) Pub Date : 2019-12-09 Anna-Lina Gerberding,Silvia Zampar,Martina Stazi,David Liebetanz,Oliver Wirths
Alzheimer’s disease (AD) is the most common form of dementia. There is accumulating evidence that in addition to genetics, other lifestyle and environmental factors may have a share in the individual risk of getting AD, which opens new opportunities for prevention (Mattson, 2015). Risk factors include diabetes mellitus, midlife obesity and hypertension, smoking, depression and dyslipidemia (Mayeux
-
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis. ASN Neuro (IF 4.167) Pub Date : 2019-12-03 Aubin Moutal,Sergey Kalinin,Kathy Kowal,Natalia Marangoni,Jeffrey Dupree,Shao Xia Lin,Kinga Lis,Lucia Lisi,Kenneth Hensley,Rajesh Khanna,Douglas L Feinstein
We previously showed that clinical scores in the myelin oligodendrocyte glycoprotein (MOG)35–55 peptide-induced experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) were significantly reduced by administration of lanthionine ketimine ethyl ester (LKE), accompanied by reductions in axonal damage in spinal cord and optic nerve (Dupree et al., 2015). LKE is a derivatized form
-
Intracerebroventricular Infusion of Gangliosides Augments the Adult Neural Stem Cell Pool in Mouse Brain. ASN Neuro (IF 4.167) Pub Date : 2019-10-21 Yutaka Itokazu,Dongpei Li,Robert K Yu
We previously reported that ganglioside GD3 is the predominant species in neural stem cells (NSCs) and reduced postnatal NSC pools are observed in both the subventricular zone and dentate gyrus (DG) of GD3-synthase knockout (GD3S-KO) mouse brains. Specifically, deficiency of GD3 in GD3S-KO animals revealed a dramatic reduction in cellularity in the DG of the hippocampus of the developing mouse brain
-
Erythropoietin as a Neuroprotective Molecule: An Overview of Its Therapeutic Potential in Neurodegenerative Diseases. ASN Neuro (IF 4.167) Pub Date : 2019-08-26 Federica Rey,Alice Balsari,Toniella Giallongo,Sara Ottolenghi,Anna M Di Giulio,Michele Samaja,Stephana Carelli
Erythropoietin (EPO) is a 30-kDa molecular weight glycoprotein of 165 amino acids, coded by the EPO gene, located on Chromosome 7 (Law et al., 1986). EPO presents one small O-linked glycan and three tetra-antennary N-linked polysaccharide units, fundamental for its secretion, molecular stability, and binding to its receptor, erythropoietin receptor (EPOR; Tsuda et al., 1988). EPO is a type I cytokine
-
Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia. ASN Neuro (IF 4.167) Pub Date : 2019-07-30 David J Braun,Erin Abner,Vikas Bakshi,Danielle S Goulding,Elizabeth M Grau,Ai-Ling Lin,Christopher M Norris,Tiffany L Sudduth,Scott J Webster,Donna M Wilcock,Linda J Van Eldik
Elevated blood levels of the amino acid homocysteine, termed hyperhomocysteinemia (HHcy), is a risk factor for cognitive impairment and dementia (Smith et al., 2018). Strikingly, the population attributable risk of Alzheimer’s disease (AD) due to HHcy is estimated to be as high as 31% (Van Dam & Van Gool, 2009; Smith et al., 2018), and it follows that successful treatment of this condition may significantly
-
2019 Academic Annual Meeting and the Frontier Seminar on "Glial Cell Function and Disease" (Nantong, China). ASN Neuro (IF 4.167) Pub Date : 2019-07-25 Yu-Feng Wang,Yong-Jing Gao
Increased attention to the role of glial activities in neural functions and diseases has drawn the participation of more than 180 experts who engaged in glial cell research to the 2019 Academic Annual Meeting and the Frontier Seminar on “Glial Cell Function and Disease” held in Nantong, China from May 24 to 26. The meeting was organized by Drs. Yong-Jing Gao and Jia-Wei Zhou of the Chinese Society
-
MicroRNAs 145 and 148a Are Upregulated During Congenital Zika Virus Infection. ASN Neuro (IF 4.167) Pub Date : 2019-06-19 Fernanda L Castro,Victor E V Geddes,Fábio L L Monteiro,Raphael M D T Gonçalves,Loraine Campanati,Paula Pezzuto,Dominic Paquin-Proulx,Bruno L Schamber-Reis,Girlene S Azevedo,Alessandro L Gonçalves,Daniela P Cunha,Maria Elisabeth L Moreira,Zilton F M Vasconcelos,Leila Chimeli,Adriana Melo,Amilcar Tanuri,Douglas F Nixon,Marcelo Ribeiro-Alves,Renato S Aguiar
Zika virus (ZIKV) is an arthropod-borne virus member of the Flaviviridae family, Flavivirus genus. The family comprises viruses with positive-sense RNA genomes, and other family members include important human pathogens including Yellow Fever Virus (YFV), Dengue Virus (DENV), West Nile Virus (WNV), Japanese Encephalitis Virus (JEV), and Spondweni Virus (SPOV). Although ZIKV was repeatedly isolated
-
Alterations of Calcium Channels in a Mouse Model of Huntington's Disease and Neuroprotection by Blockage of CaV1 Channels. ASN Neuro (IF 4.167) Pub Date : 2019-06-19 Artur S Miranda,Pablo Leal Cardozo,Flavia R Silva,Jessica M de Souza,Isabella G Olmo,Jader S Cruz,Marcus Vinícius Gomez,Fabiola M Ribeiro,Luciene B Vieira
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by symptoms that include involuntary movement of the body, loss of cognitive function, psychiatric disorders, and inevitable death (Ehrnhoefer et al., 2009, Labbadia and Morimoto, 2013). HD is an autosomal dominant disease caused by poly-glutamine expansion in a protein named huntingtin (Htt), leading to aggregate formation
-
Identification of the Molecular Events Involved in the Development of Prefrontal Cortex Through the Analysis of RNA-Seq Data From BrainSpan. ASN Neuro (IF 4.167) Pub Date : 2019-06-18 Hadi Najafi,Mohadeseh Naseri,Javad Zahiri,Mehdi Totonchi,Majid Sadeghizadeh
Brain development is a very complex, dynamic, and multistage process that involves precisely orchestrated sequence of cellular and molecular events (Silbereis et al., 2016). This development begins within weeks of conception (∼third gestational week) and continues through the adolescence (Stiles and Jernigan, 2010). Many controlled morphogenesis processes such as cell division, differentiation, migration
-
Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression. ASN Neuro (IF 4.167) Pub Date : 2019-06-18 Caleigh A Findley,Andrzej Bartke,Kevin N Hascup,Erin R Hascup
The glutamatergic synapse, referred to as the tripartite synapse, involves three elements: presynaptic neurons, postsynaptic neurons, and astrocytes. There are several different synaptic components expressed on both neurons and astrocytes in the glutamate synapse, as summarized in Table 1. These components include two types of glutamate receptors that exist on these synaptic elements: metabotropic
-
Small Interference RNA Targeting Connexin-43 Improves Motor Function and Limits Astrogliosis After Juvenile Traumatic Brain Injury. ASN Neuro (IF 4.167) Pub Date : 2019-06-13 Aleksandra Ichkova,Andrew M Fukuda,Nina Nishiyama,Germaine Paris,Andre Obenaus,Jerome Badaut
In the United States, the annual incidence of nonmilitary-related traumatic brain injury (TBI) is approximately 1.7 million, of which 327,000 are hospitalized and 52,000 die (Faul et al., 2010). Juvenile TBI (jTBI), which is the leading cause of death and disability in children and adolescents, is an important concern because the population group most affected (emergency department visit, hospitalization
-
Higher Level of Mismatch in APOEε4 Carriers for Amyloid-Beta Peptide Alzheimer's Disease Biomarkers in Cerebrospinal Fluid. ASN Neuro (IF 4.167) Pub Date : 2019-05-19 Jonathan Vogelgsang,Ruth Vukovich,Dirk Wedekind,Jens Wiltfang
Cerebrospinal fluid (CSF) biomarkers are widely used in the diagnosis of dementia. Even though there is a causal correlation between apolipoprotein E ( APOE) genotype and amyloid-beta (Aβ), the determination of APOE is currently not supported by national or international guidelines. We compared parallel measured CSF biomarkers of two independent laboratories from 126 patients who underwent clinical
-
Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus. ASN Neuro (IF 4.167) Pub Date : 2019-05-17 Ping Wang,Stephani C Wang,Dongyang Li,Tong Li,Hai-Peng Yang,Liwei Wang,Yu-Feng Wang,Vladimir Parpura
In the supraoptic nucleus (SON), the incidence of dye coupling among oxytocin (OT) neurons increases significantly in nursing mothers. However, the type(s) of connexin (Cx) involved is(are) unknown. In this study, we specifically investigated whether Cx36 plays a functional role in the coupling between OT neurons in the SON of lactating rats. In this brain region, Cx36 was mainly coimmunostained with
-
Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways. ASN Neuro (IF 4.167) Pub Date : 2019-05-14 Connie J Liou,Ming Tong,Jean P Vonsattel,Suzanne M de la Monte
BACKGROUND Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. OBJECTIVE Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted us to measure a panel of trophic factors, receptors, and molecules that modulate brain metabolic function in FTLD. METHODS Postmortem frontal (Brodmann's
-
Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress. ASN Neuro (IF 4.167) Pub Date : 2019-05-03 Muwoong Kim,Hyosun Kim,Dogyeong Kim,Dokyoung Kim,Youngbuhm Huh,Chan Park,Hyung-Joo Chung,Junyang Jung,Na Young Jeong
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells. This recharacterized Schwann cell guides newly regrowing axons to their destination and remyelinates reinnervated axons. This Schwann cell dynamics during Wallerian degeneration is associated with oxidative events. Heme oxygenases (HOs) are involved
-
Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model. ASN Neuro (IF 4.167) Pub Date : 2019-04-21 Miriam S Domowicz,Wen-Ching Chan,Patricia Claudio-Vázquez,Judith G Henry,Christopher B Ware,Jorge Andrade,Glyn Dawson,Nancy B Schwartz
In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human disease, we analyzed end-stage (4 months) transcriptional changes associated with lack of TPP1 activity
-
Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures. ASN Neuro (IF 4.167) Pub Date : 2019-03-14 Eliana Scemes,Libor Velíšek,Jana Velíšková
ATP- and adenosine-mediated signaling are prominent types of glia-glia and glia-neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures. Pannexin1 (Panx1), a member of the gap junction family, is an ATP release channel that is expressed in astrocytes and neurons. Previous studies provided evidence supporting a role for purinergic-mediated
-
Sildenafil Inhibits Myelin Expression and Myelination of Oligodendroglial Precursor Cells. ASN Neuro (IF 4.167) Pub Date : 2019-03-10 Jonathan Muñoz-Esquivel,Peter Göttle,Lucinda Aguirre-Cruz,José Flores-Rivera,Teresa Corona,Gustavo Reyes-Terán,Patrick Küry,Klintsy J Torres
Phosphodiesterases (PDEs) have previously been implicated in oligodendrocyte maturation and myelination of central nervous system axons. Sildenafil citrate is a phosphodiesterase inhibitor known to block PDE5, which also reduces inflammation in the experimental autoimmune encephalomyelitis demyelinating model. To find out whether this inhibitor might exert beneficial effects on central nervous system
-
Subacute Transplantation of Native and Genetically Engineered Neural Progenitors Seeded on Microsphere Scaffolds Promote Repair and Functional Recovery After Traumatic Brain Injury. ASN Neuro (IF 4.167) Pub Date : 2019-03-02 Nolan B Skop,Sweta Singh,Henri Antikainen,Chaitali Saqcena,Frances Calderon,Deborah E Rothbard,Cheul H Cho,Chirag D Gandhi,Steven W Levison,Radek Dobrowolski
There is intense interest and effort toward regenerating the brain after severe injury. Stem cell transplantation after insult to the central nervous system has been regarded as the most promising approach for repair; however, engrafting cells alone might not be sufficient for effective regeneration. In this study, we have compared neural progenitors (NPs) from the fetal ventricular zone (VZ), the
-
A Longitudinal Investigation of Sleep and Daytime Wakefulness in Children and Youth With Concussion. ASN Neuro (IF 4.167) Pub Date : 2019-02-27 Catherine Wiseman-Hakes,Nadia Gosselin,Bhanu Sharma,Laura Langer,Isabelle Gagnon
A high proportion of adults who sustain a concussion identify changes in their sleep during the acute stage, typically reporting an increased need for sleep or nonrestful sleep. Our understanding of sleep following concussion is less well understood within a pediatric population. In this study, we investigated the trajectory of sleep and daytime sleepiness in a prospective cohort of 40 children and
-
α-Synuclein Trafficking in Parkinson's Disease: Insights From Fly and Mouse Models. ASN Neuro (IF 4.167) Pub Date : 2018-11-30 Jingjing Cheng,Qingqing Lu,Li Song,Margaret S Ho
Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases. To efficiently clear and eliminate such aggregation becomes an important cellular strategy for cell survival. Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson's disease (PD) serve as a good example and are potentially linked to other pathological PD
-
L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats. ASN Neuro (IF 4.167) Pub Date : 2018-11-16 Yixian Huang,Haiyang Shu,Li Li,Tili Zhen,Junyan Zhao,Xianju Zhou,Weifeng Luo
Levodopa (L-DOPA) is still the most effective drug for the treatment of Parkinson's disease (PD). However, the long-term therapy often triggers L-DOPA-induced dyskinesia (LID). Metabotropic glutamate receptor type 5 (mGluR5) is abundant in the basal ganglia, and its inhibition is thought to modulate postsynaptic excitatory synaptic transmission and glutamate hyperactivity in PD and LID. In this report
-
Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction. ASN Neuro (IF 4.167) Pub Date : 2018-11-15 Ji Heun Jeong,Do Kyung Kim,Nam-Seob Lee,Young-Gil Jeong,Ho Won Kim,Jong-Seok Kim,Seung-Yun Han
Hyperammonemia associated with overt hepatic encephalopathy (OHE) causes excitotoxic neuronal death through activation of the cytochrome C (CytC)-mediated mitochondria-dependent apoptotic pathway. We tested the therapeutic effect of nortriptyline (NT), a mitochondrial permeability transition pore (mPTP) blocker that can possibly inhibit mitochondrial CytC efflux to the cytosol on in vivo and in vitro
-
An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination. ASN Neuro (IF 4.167) Pub Date : 2018-11-14 Danielle C Robinson,Anna E Mammel,Anne M Logan,Aubree A Larson,Eric J Schmidt,Alec F Condon,Fred L Robinson
Charcot-Marie-Tooth Disorder Type 4B (CMT4B) is a demyelinating peripheral neuropathy caused by mutations in myotubularin-related (MTMR) proteins 2, 13, or 5 (CMT4B1/2/3), which regulate phosphoinositide turnover and endosomal trafficking. Although mouse models of CMT4B2 exist, an in vitro model would make possible pharmacological and reverse genetic experiments needed to clarify the role of MTMR13