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Synaptic and Network Contributions to Anoxic Depolarization in Mouse Hippocampal Slices Neuroscience (IF 3.056) Pub Date : 2021-02-24 Bradley S. Heit; Patricia Dykas; Alex Chu; Abhay Sane; John Larson
Ischemic stroke remains the third leading cause of death and leading cause of adult disability worldwide. A key event in the pathophysiology of stroke is the anoxic depolarization (AD) of neurons in the ischemic core. Previous studies have established that both the latency to AD and the time spent in AD prior to re-oxygenation are predictors of neuronal death. The present studies used hippocampal slices
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Recovering Spatial Information through Reactivation: Brain Oxidative Metabolism Involvement in Males and Females Neuroscience (IF 3.056) Pub Date : 2021-02-09 Candela Zorzo; Jorge L. Arias; Marta Méndez
Memory involves a complex network system of interconnected brain areas in which labile trace memories are transformed into enduring ones and reorganized in a time-dependant manner. Although it has been observed that remote memories are less prone to destabilizing, they can become fragile and lead to behavioural decline. We explored the behavioural outcomes of male and female rats in response to the
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Discrimination of Regular and Irregular Rhythms Explained by a Time Difference Accumulation Model Neuroscience (IF 3.056) Pub Date : 2021-02-05 Marisol Espinoza-Monroy; Victor de Lafuente
Perceiving the temporal regularity in a sequence of repetitive sensory events facilitates the preparation and execution of relevant behaviors with tight temporal constraints. How we estimate temporal regularity from repeating patterns of sensory stimuli is not completely understood. We developed a decision-making task in which participants had to decide whether a train of visual, auditory, or tactile
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Phosphofructokinase-1 Inhibition Promotes Neuronal Differentiation of Neural Stem Cells and Functional Recovery After Stroke Neuroscience (IF 3.056) Pub Date : 2021-02-06 Fengyun Zhang; Qiangming Li; Haiying Liang; Yuxia Zhang
Ischemic stroke is a major cause of long-term disability. Neuronal differentiation of neural stem cells (NSCs) is crucial for brain repair after stroke. However, the underlying mechanisms remain unclear. Here, the role and potential mechanisms of phosphofructokinase-1 (PFK-1), the rate-limiting enzyme of glycolysis, was investigated in stroke using middle cerebral artery occlusion (MCAO) and oxygen-glucose
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The Neural Signature of Social Dominance Discrimination by Means of Fast Periodic Visual Stimulation Neuroscience (IF 3.056) Pub Date : 2021-02-02 Yaner Su; Qiuling Luo; Shaozhen Tan; Chen Qu
Hierarchy is a pervasive feature of social organization. The ability to rapidly discriminate hierarchical information is critical for social interaction. Here, we took advantage of a special technique in electroencephalography (EEG) known as fast periodic visual stimulation (FPVS). We used this technique, which captures the automatic perception of faces, to explore the neural signature of social dominance
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EEG Decoding of Dynamic Facial Expressions of Emotion: Evidence from SSVEP and Causal Cortical Network Dynamics Neuroscience (IF 3.056) Pub Date : 2021-02-06 Meng-Yun Wang; Zhen Yuan
The neural cognitive mechanism in processing static facial expressions (FEs) has been well documented, whereas the one underlying perceiving dynamic faces remains unclear. In this study, Fourier transformation and time–frequency analysis of Electroencephalography (EEG) data were carried out to detect the brain activation underlying dynamic or static FEs while twenty-one participants were viewing dynamic
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Effect of Contralateral Noise on Speech Intelligibility Neuroscience (IF 3.056) Pub Date : 2021-02-04 Beate Wendt; Jörg Stadler; Jesko L. Verhey; Horst Hessel; Nicole Angenstein
In patients with strong asymmetric hearing loss, standard clinical practice involves testing speech intelligibility in the ear with the higher hearing threshold by simultaneously presenting noise to the other ear. However, psychoacoustic and functional magnetic resonance imaging (fMRI) studies indicate that this approach may be problematic as contralateral noise has a disruptive effect on task processing
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Motor thalamic deep brain stimulation alters cortical activity and shows therapeutic utility for treatment of Parkinson’s disease symptoms in a rat model Neuroscience (IF 3.056) Pub Date : 2021-02-23 Heidi R. Tucker; Emily Mahoney; Kainat Akhtar; Tzu-Jen Kao; Gianna Mamone; Saisree Mikkilineni; Maya Ravi; Hanel Watkins; Danielle-Lee Terrelonge; Caryn Martin; Kristen Unger; Gabrielle Kim; Kyra Fiber; Megan Gupta; Jonathan Indajang; Eliyahu M. Kochman; Natasha Sachs; Paul Feustel; Damian S. Shin
Deep brain stimulation (DBS) in Parkinson’s disease (PD) alters neuronal function and network communication to improve motor symptoms. The subthalamic nucleus (STN) is the most common DBS target for PD, but some patients experience adverse effects on memory and cognition. Previously, we reported that DBS of the ventral anterior (VA) and ventrolateral (VL) nuclei of the thalamus and at the interface
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Receptors, channel proteins, and enzymes involved in microglia-mediated neuroinflammation and treatments by targeting microglia in ischemic stroke Neuroscience (IF 3.056) Pub Date : 2021-02-18 Kun Hou; Guichen Li; Jinlu Yu; Kan Xu; Wei Wu
Stroke is the largest contributor to global neurological disability-adjusted life-years, posing a huge economic and social burden to the world. Though pharmacological recanalization with recombinant tissue plasminogen activator and mechanical thrombectomy have greatly improved the prognosis of patients with ischemic stroke, clinically, there is still no effective treatment for the secondary injury
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Organization of afferents along the anterior-posterior and medial-lateral axes of the rat orbitofrontal cortex Neuroscience (IF 3.056) Pub Date : 2021-02-18 Ines V. Barreiros; Marios C. Panayi; Mark E. Walton
The orbitofrontal cortex (OFC) has been anatomically divided into a number of subregions along its medial-lateral axis, which behavioral research suggests have distinct functions. Recently, evidence has emerged suggesting functional diversity is also present along the anterior-posterior axis of the rodent OFC. However, the patterns of anatomical connections that underlie these differences have not
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Role of α2δ3 in cellular synchronization of the suprachiasmatic nucleus under constant light conditions Neuroscience (IF 3.056) Pub Date : 2021-02-18 Masahiro Matsuo; Kazuyuki Seo; Naoki Mizuguchi; Fumiyoshi Yamazaki; Shoichi Urabe; Naoto Yamada; Masao Doi; Keiko Tominaga; Hitoshi Okamura
By the effort to identify candidate signaling molecules important for the formation of robust circadian rhythms in the suprachiasmatic nucleus (SCN), the mammalian circadian center, here we characterize the role of α2δ proteins, synaptic molecules initially identified as an auxiliary subunit of the voltage dependent calcium channel, in circadian rhythm formation. In situ hybridization study demonstrated
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High-fat feeding causes inflammation and insulin resistance in the ventral tegmental area in mice Neuroscience (IF 3.056) Pub Date : 2021-02-18 Akira Mizoguchi; Ryoichi Banno; Runan Sun; Hiroshi Yaginuma; Keigo Taki; Tomoko Kobayashi; Mariko Sugiyama; Taku Tsunekawa; Takeshi Onoue; Hiroshi Takagi; Daisuke Hagiwara; Yoshihiro Ito; Shintaro Iwama; Hidetaka Suga; Hiroshi Arima
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Deciphering Sounds Through Patterns of Vibration on the Skin Neuroscience (IF 3.056) Pub Date : 2021-01-16 Michael V. Perrotta; Thorhildur Asgeirsdottir; David M. Eagleman
Sensory substitution refers to the concept of feeding information to the brain via an atypical sensory pathway. We here examined the degree to which participants (deaf and hard of hearing) can learn to identify sounds that are algorithmically translated into spatiotemporal patterns of vibration on the skin of the wrist. In a three-alternative forced choice task, participants could determine the identity
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The effects of ageing on tactilnotee function in the human nervous system Neuroscience (IF 3.056) Pub Date : 2021-02-17 Sarah McIntyre; Saad S. Nagi; Francis McGlone; Håkan Olausson
Ageing is accompanied by a steady decline in touch sensitivity and acuity. Conversely, pleasant touch, such as experienced during a caress, is even more pleasant in old age. There are many physiological changes that might explain these perceptual changes, but researchers have not yet identified any specific mechanisms. Here, we review both the perceptual and structural changes to the touch system that
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Neural Mechanism of Affective Perception: Evidence from Phase and Causality Analysis in the Cerebral Cortex Neuroscience (IF 3.056) Pub Date : 2021-02-17 Ning Zhuang; Lin Jiang; Bin Yan; Li Tong; Jun Shu; Kai Yang; Dezhong Yao; Peng Xu; Ying Zeng
Emotion plays an important role in people’s lives. However, the neural mechanism of affective perception is still unclear. In this study, steady-state visual evoked potentials (SSVEPs) were used to explore information processing speed and interactions among cortical structures involved in affective perception. Pleasant, unpleasant, and neutral pictures selected from the International Affective Picture
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Reduction of autophagosome overload attenuates neuronal cell death after traumatic brain injury Neuroscience (IF 3.056) Pub Date : 2021-02-16 Xingyun Quan; Li Song; Xiaomei Zheng; Shenjie Liu; Huaqiang Ding; Sijing Li; Guanghui Xu; Xin Li; Liang Liu
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EGR1 knockdown alleviates the cerebral injury in rats with intracerebral hemorrhage (ICH) via STAT3/NF-κB pathway by reducing RXRα acetylation level Neuroscience (IF 3.056) Pub Date : 2021-02-16 Lijuan Xie; Yingying Wang; Zhuo Chen
Brain EGR1 (early growth response protein 1) overexpression aggravates focal ischemic brain injury, but its role in intracerebral hemorrhage (ICH) induced cerebral injury remains obscure. In this study, a rat ICH model was established by injecting type VII collagenase into the brain, and EGR1 knockdown reversed the increase of hematoma area, neurological function score, brain water content, blood-brain
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Impact of depletion of microglia/macrophages on regeneration after spinal cord injury Neuroscience (IF 3.056) Pub Date : 2021-02-13 Igor Jakovčevski; Eckart Förster; Gebhard Reiss; Melitta Schachner
Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated microglia/macrophages clear tissue debris, but activation over time may hamper repair. To study the role of these cells in regeneration after spinal cord
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Sex-related differences in stress reactivity and cingulum white matter Neuroscience (IF 3.056) Pub Date : 2021-02-13 M.D. Wheelock; A.M. Goodman; N.G. Harnett; K.H. Wood; S. Mrug; D.A. Granger; D.C. Knight
The prefrontal cortex and limbic system are important components of the neural circuit that underlies stress and anxiety. These brain regions are connected by white matter tracts that support neural communication including the cingulum, uncinate fasciculus, and the fornix/stria-terminalis. Determining the relationship between stress reactivity and these white matter tracts may provide new insight into
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Frontoparietal beta amplitude modulation and its interareal cross-frequency coupling in visual working memory Neuroscience (IF 3.056) Pub Date : 2021-02-13 Wei-Kuang Liang; Philip Tseng; Jia-Rong Yeh; Norden E Huang; Chi-Hung Juan
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Divergent alterations of structural-functional connectivity couplings in first-episode and chronic schizophrenia patients Neuroscience (IF 3.056) Pub Date : 2021-02-13 Ling-yin Kong; Yuan-yuan Huang; Bing-ye Lei; Peng-fei Ke; He-hua Li; Jing Zhou; Dong-sheng Xiong; Gui-xiang Li; Jun Chen; Xiao-bo Li; Zhi-ming Xiang; Yu-ping Ning; Feng-chun Wu; Kai Wu
Emerging evidence suggests that the coupling relating the structural connectivity (SC) of the brain to its functional connectivity (FC) exhibits remarkable changes during development, normal aging, and diseases. Although altered structural-functional connectivity couplings (SC-FC couplings) have been previously reported in schizophrenia patients, the alterations in SC-FC couplings of different illness
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The effects of human milk oligosaccharide supplementation during critical periods of development on the mesolimbic dopamine system Neuroscience (IF 3.056) Pub Date : 2021-02-13 Erin W Noye Tuplin; Faye Chleilat; Erna Alukic; Raylene A. Reimer
Human milk oligosaccharides (HMO)s are a key component in human milk and represent an important dietary modulator of infant gut microbiota composition and associated gut-brain axis development and homeostasis. The brain reward system, specifically the mesolimbic dopamine (DA) projections from the ventral tegmental area (VTA) to nucleus accumbens (NAc) is involved in the motivation and preference for
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Differential Cortical Pattern in Auditory Task Oddball Paradigm in Children Exposed to Alcohol during Pregnancy Neuroscience (IF 3.056) Pub Date : 2021-01-27 Humberto de Oliveira Simões; Sthella Zanchetta; Erikson Felipe Furtado
The negative effects of fetal alcohol exposure on child development are well documented. This study investigated the electrophysiological processing of cortical level acoustic signals in a group of 21 children prenatally exposed to alcohol. Participants aged 13–14 years at the time of the study were recruited from a longitudinal cohort sample. The study employed an observational, cross-sectional blind
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Observed and performed error signals in auditory lexical decisions Neuroscience (IF 3.056) Pub Date : 2021-02-10 Duru G. Özkan; Mirjam Broersma; Harold Bekkering; Sybrine Bultena
This study investigates the error processing components in the EEG signal of Performers and Observers using an auditory lexical decision task, in which participants heard spoken items and decided for each item if it was a real word or not. Pairs of participants were tested in both the role of the Performer and the Observer. In the literature, an Error Related Negativity-Error Positivity complex has
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SCO-spondin-derived peptide protects neurons from glutamate-induced excitotoxicity Neuroscience (IF 3.056) Pub Date : 2021-02-10 Nathalie Delétage; Juliette Le Douce; Noëlle Callizot; Yann Godfrin; Sighild Lemarchant
Subcommissural organ (SCO)-spondin is a brain-specific glycoprotein produced during embryogenesis, that strongly contributes to neuronal development. The SCO becomes atrophic in adults, halting SCO-spondin production and its neuroprotective functions. Using rat and human neuronal cultures, we evaluated the neuroprotective effect of an innovative peptide derived from SCO-spondin against glutamate excitotoxicity
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Regulatory Role of Ubiquitin Specific Protease-13 (USP13) in Misfolded Protein Clearance in Neurodegenerative Diseases Neuroscience (IF 3.056) Pub Date : 2021-02-10 Xiaoguang Liu; Charbel Moussa
Ubiquitin specific protease (USP)-13 is a de-ubiquitinase member of the cysteine-dependent protease superfamily that cleaves ubiquitin off protein substrates to reverse ubiquitin-mediated protein degradation. Several findings implicate USPs in neurodegeneration. Ubiquitin targets proteins to major degradation pathways, including the proteasome and the lysosome. In melanoma cells, USP13 regulates the
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Quantitative cellular changes in the thalamus of patients with Multiple System Atrophy Neuroscience (IF 3.056) Pub Date : 2021-02-10 Tanya R. Vigen; Tomasz Brudek; Bente Pakkenberg; Mikkel V. Olesen
The thalamus is a brain region consisting of anatomical and functional connections between various spinal, subcortical, and cortical regions, which has a putative role in the clinical manifestation of Multiple System Atrophy (MSA). Previous stereological studies have reported significant anatomical alterations in diverse brain regions of MSA patients, including the cerebral cortex, basal ganglia and
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HCN channel phosphorylation sites mapped by mass spectrometry in human epilepsy patients and in an animal model of temporal lobe epilepsy Neuroscience (IF 3.056) Pub Date : 2021-02-09 F.A. Concepcion; M.N. Khan; J-D. Ju Wang; A.D. Wei; J.G. Ojemann; A.L. Ko; Y. Shi; J.K. Eng; J.M. Ramirez; N.P. Poolos
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Loss of Brain-Derived Neurotrophic Factor (BDNF) Resulting From Congenital- Or Mild Traumatic Brain Injury-Induced Blood–Brain Barrier Disruption Correlates With Depressive-Like Behaviour Neuroscience (IF 3.056) Pub Date : 2021-01-17 Anna Lesniak; Piotr Poznański; Piotr Religa; Agata Nawrocka; Magdalena Bujalska-Zadrozny; Mariusz Sacharczuk
Brain-derived neurotrophic factor (BDNF) plays an important role in processes associated with neuroplasticity and neuroprotection. Evidence suggests that decreased BDNF levels in the central nervous system (CNS) represent a mechanism underlying the development of mood disorders. We hypothesize that both congenital and traumatic brain injury (mTBI)-induced blood–brain barrier (BBB) breakdown are responsible
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Scaling of Network Excitability and Inhibition may Contribute to the Septotemporal Differentiation of Sharp Waves–Ripples in Rat Hippocampus In Vitro Neuroscience (IF 3.056) Pub Date : 2021-01-17 George Trompoukis; Leonidas J. Leontiadis; Pavlos Rigas; Costas Papatheodoropoulos
The functional organization of the hippocampus along its longitudinal (septotemporal or dorsoventral) axis is conspicuously heterogeneous. This functional diversification includes the activity of sharp wave and ripples (SPW–Rs), a complex intrinsic network pattern involved in memory consolidation. In this study, using transverse slices from the ventral and the dorsal rat hippocampus and recordings
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Detoxification of Reactive Aldehydes by Alda-1 Treatment Ameliorates Experimental Autoimmune Encephalomyelitis in Mice Neuroscience (IF 3.056) Pub Date : 2021-01-23 S.M. Touhidul Islam; Jeseong Won; Judong Kim; Fei Qiao; Avtar K. Singh; Mushfiquddin Khan; Inderjit Singh
Reactive aldehydes are generated as a toxic end-product of lipid peroxidation under inflammatory oxidative stress condition which is a well-established phenomenon in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Alda-1, a selective agonist of mitochondrial aldehyde dehydrogenase 2 (ALDH2), is known to detoxify the reactive aldehydes
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Individual Differences in Autistic Traits are Associated with Serotonin Transporter Gene Polymorphism Through Medial Prefrontal Function: A Study Using NIRS Neuroscience (IF 3.056) Pub Date : 2021-01-16 Akiko Kawamoto; Aiko Kajiume; Hiroshi Yoshida; Tamotsu Toshima; Masao Kobayashi
Autism spectrum disorder (ASD) is a heritable neurodevelopmental disorder that can vary considerably in severity. Autistic traits are distributed continuously across populations, even in sub-clinical individuals. Serotonin transporter-gene polymorphic region (5-HTTLPR) has been studied as a candidate genetic factor related to ASD, however results have been inconsistent. 5-HTTLPR is implicated in the
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Early hypoexcitability in a subgroup of spinal motoneurons in superoxide dismutase 1 transgenic mice, a model of amyotrophic lateral sclerosis Neuroscience (IF 3.056) Pub Date : 2021-02-06 Anton Filipchuk; Arnaud Pambo-Pambo; Fanny Gaudel; Sylvie Liabeuf; Cécile Brocard; Jean Patrick Gueritaud; Jacques Durand
In amyotrophic lateral sclerosis (ALS), large motoneurons degenerate first, causing muscle weakness. Transgenic mouse models with a mutation in the gene encoding the enzyme superoxide dismutase 1 (SOD1) revealed that motoneurons innervating the fast-fatigable muscular fibres disconnect very early. The cause of this peripheric disconnection has not yet been established. Early pathological signs were
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Axonal TAU sorting is independent of ANKG and TRIM46 enrichment at the AIS in SH-SY5Y-derived neurons Neuroscience (IF 3.056) Pub Date : 2021-02-06 M. Bell; S. Bachmann; J. Klimek; F. Langerscheidt; H. Zempel
Somatodendritic missorting of the axonal protein TAU is a hallmark of Alzheimer’s disease and related tauopathies. Rodent primary neurons and iPSC-derived neurons are used for studying mechanisms of neuronal polarity, including TAU trafficking. However, these models are expensive, time-consuming and/or require the sacrification of animals. In this study, we evaluated four differentiation procedures
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Task- and Rest-based Functional Brain Connectivity in Food-related Reward Processes among Healthy Adolescents Neuroscience (IF 3.056) Pub Date : 2021-01-21 Céline Charroud; Gaëtan Poulen; Emily Sanrey; Nicolas Menjot de Champfleur; Jérémy Deverdun; Philippe Coubes; Emmanuelle Le Bars
It is known that the nucleus accumbens, orbitofrontal cortex and insula play a role in food-related reward processes. Although their interconnectedness would be an ideal topic for understanding food intake mechanisms, it nevertheless remains unclear especially in adolescent. Therefore, this study aims to investigate the effect of hunger on functional connectivity in healthy adolescents using task-
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Coordinating Initial and Final Action Goals in Planning Grasp-to-Rotate Movements: An ERP Study Neuroscience (IF 3.056) Pub Date : 2021-02-04 Lin Yu; Thomas Schack; Dirk Koester
Action goals have often been investigated in previous studies within a single action. However, most of the manual actions (such as prehension) are not restricted to a single action towards the object but can involve multiple follow-up actions to achieve a further purpose. The coordination of the initial (grip posture) and final (task purpose) action goals within such complex actions is still not fully
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Increasead cholinergic tone causes pre-synaptic neuromuscular degeneration and is associated with impaired diaphragm function Neuroscience (IF 3.056) Pub Date : 2021-02-04 Matheus P.S. Magalhães-Gomes; Wallace Camargos; Priscila A.C. Valadão; Rubens S. Garcias; Hermann A. Rodrigues; Jéssica N. Andrade; Vanessa P. Teixeira; Lígia A.N. Kushmerick; Walter L.G. Cavalcante; Marcia Gallaci; Silvia Guatimosim; Vânia F. Prado; Marco A.M. Prado; Cristina Guatimosim
In vertebrates, muscle activity is dependent on acetylcholine (ACh) released from neuromuscular junctions (NMJs), and changes in cholinergic neurotransmission are linked to a variety of neuromuscular diseases, including congenital myasthenic syndromes (CMS). The storage and release of ACh depends on the activity of the Vesicular Acetylcholine Transporter (VAChT), a rate-limiting step for cholinergic
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Gray Matter Volume Differences Between More Versus Less Resilient Adults with Chronic Musculoskeletal Pain: A Voxel-based Morphology Study Neuroscience (IF 3.056) Pub Date : 2021-01-21 Beibei You; Todd Jackson
Resilience, a personality construct that reflects capacities to persevere, maintain a positive outlook and/or thrive despite ongoing stressors, has emerged as an important focus of research on chronic pain (CP). Although behavior studies have found more resilient persons with CP experience less pain-related dysfunction than less resilient cohorts do, the presence and nature of associated brain structure
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Longitudinal Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) Derived Metrics in the White Matter Neuroscience (IF 3.056) Pub Date : 2021-01-17 Nico Lehmann; Norman Aye; Jörn Kaufmann; Hans-Jochen Heinze; Emrah Düzel; Gabriel Ziegler; Marco Taubert
Diffusion-weighted magnetic resonance imaging (DWI) is undergoing constant evolution with the ambitious goal of developing in-vivo histology of the brain. A recent methodological advancement is Neurite Orientation Dispersion and Density Imaging (NODDI), a histologically validated multi-compartment model to yield microstructural features of brain tissue such as geometric complexity and neurite packing
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The Localization of Alpha-synuclein in the Endocytic Pathway Neuroscience (IF 3.056) Pub Date : 2021-01-20 Mohammad A.A. Fakhree; Irene B.M. Konings; Jeroen Kole; Alessandra Cambi; Christian Blum; Mireille M.A.E. Claessens
Alpha-synuclein (αS) is an intrinsically disordered protein (IDP) that is abundantly present in the brain and is associated with Parkinson's disease (PD). In spite of its abundance and its contribution to PD pathogenesis, the exact cellular function of αS remains largely unknown. The ability of αS to remodel phospholipid model membranes combined with biochemical and cellular studies suggests that αS
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Association of peripheral plasma neurotransmitters with cognitive performance in chronic high-altitude exposure Neuroscience (IF 3.056) Pub Date : 2021-02-02 Zhifeng Zhong; Simin Zhou; Bin Xiang; Yu Wu; Jiaxin Xie; Peng Li
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Silencing Epidermal Growth Factor Receptor in Hypothalamic Paraventricular Nucleus Reduces ERK1/2 Signaling and Sympathetic Excitation in Heart Failure Rats Neuroscience (IF 3.056) Pub Date : 2021-02-02 Yang Yu; Shun-Guang Wei; Robert M. Weiss; Robert B Felder
Activation of ERK1/2 signaling in cardiovascular regulatory regions of the brain contributes to sympathetic excitation in myocardial infarction (MI)-induced heart failure (HF) by increasing brain renin-angiotensin system (RAS) activity, neuroinflammation, and endoplasmic reticulum (ER) stress. The mechanisms eliciting brain ERK1/2 signaling in HF are still poorly understood. We tested the involvement
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Examining the role of microbiota in emotional behavior: antibiotic treatment exacerbates anxiety in high anxiety-prone male rats Neuroscience (IF 3.056) Pub Date : 2021-02-01 M.E. Glover; J.L. Cohen; J.R. Singer; M.N. Sabbagh; J.R. Rainville; M.T. Hyland; C.D. Morrow; C.T. Weaver; G.E. Hodes; Ilan A. Kerman; S.M. Clinton
Intestinal microbiota are essential for healthy gastrointestinal function and also broadly influence brain function and behavior, in part, through changes in immune function. Gastrointestinal disorders are highly comorbid with psychiatric disorders, although biological mechanisms linking these disorders are poorly understood. The present study utilized rats bred for distinct emotional behavior phenotypes
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Cotreatment of Small Gold Nanoparticles Protects Against the Increase in Cerebral Acetylcholinesterase Activity and Oxidative Stress Induced by Acute Ethanol Exposure in the Zebrafish Neuroscience (IF 3.056) Pub Date : 2021-01-17 Carolina Antunes Torres; Niuany Viel Mendes; Samira Leila Baldin; Henrique Teza Bernardo; Karine Medeiros Vieira; Rahisa Scussel; Gustavo de Bem Silveira; Paulo Cesar Lock Silveira; Ricardo Andrez Machado-de-Ávila; Eduardo Pacheco Rico
Gold nanoparticles (GNP) have emerged as an alternative to biomaterials in biomedical applications. Research has clearly demonstrated the relative safety and low toxicity of these molecules. However, the possible neuroprotective effect of GNP on the central nervous system (CNS) and its relationship with neurological and psychiatric disorders remain unclear. Zebrafish is a reliable model to investigate
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Morphine-Conditioned Placebo Analgesia in Female and Male Rats with Chronic Neuropathic Pain: c-Fos Expression in the Rostral Ventromedial Medulla Neuroscience (IF 3.056) Pub Date : 2020-12-05 Damien C. Boorman; Kevin A. Keay
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The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development of Hyperalgesia in Mice Neuroscience (IF 3.056) Pub Date : 2021-01-07 Sergey G. Khasabov; Victoria M. Rogness; Montana B. Beeson; Lucy Vulchanova-Hart; Li-Lian Yuan; Donald A. Simone; Phu V. Tran
Pain is a major health problem, affecting over fifty million adults in the US alone, with significant economic cost in medical care and lost productivity. Despite evidence implicating nicotinic acetylcholine receptors (nAChRs) in pathological pain, their specific contribution to pain processing in the spinal cord remains unclear given their presence in both neuronal and non-neuronal cell types. Here
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Music Style Not Only Modulates the Auditory Cortex, but Also Motor Related Areas Neuroscience (IF 3.056) Pub Date : 2021-01-17 Jesús Martín-Fernández; Iballa Burunat; Cristián Modroño; José Luis González-Mora; Julio Plata-Bello
The neuroscience of music has recently attracted significant attention, but the effect of music style on the activation of auditory–motor regions has not been explored. The aim of the present study is to analyze the differences in brain activity during passive listening to non-vocal excerpts of four different music genres (classical, reggaeton, electronic and folk). A functional magnetic resonance
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A Study on Resting EEG Effective Connectivity Difference before and after Neurofeedback for Children with ADHD Neuroscience (IF 3.056) Pub Date : 2021-01-19 Shanshan Wang; Dujuan Zhang; Bei Fang; Xingping Liu; Guoli Yan; Guanghong Sui; Qingwei Huang; Ling Sun; Suogang Wang
Altered functional networks in attention deficit/hyperactivity disorder (ADHD) have been frequently reported, but effective connectivity has hardly been studied. Especially the differences of effective connectivity in children with ADHD after receiving neurofeedback (NF) training have been merely reported. Therefore, this study aimed to explore the effective networks of ADHD and the positive influence
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Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation Neuroscience (IF 3.056) Pub Date : 2021-01-17 Gabriela Lazzarotto; Querusche Klippel Zanona; Kamila Cagliari Zenki; Maria Elisa Calcagnotto
Developmental cortical malformations (DCM) are one of the main causes of refractory epilepsy. Many are the mechanisms underlying the hyperexcitability in DCM, including the important contribution of N-methyl-D-aspartate receptors (NMDAR). NMDAR blockers are shown to abolish seizures and epileptiform activity. Memantine, a NMDAR antagonist used to treat Alzheimeŕs disease, has been recently investigated
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Neurodevelopment of Posture-movement Coordination from Late Childhood to Adulthood as Assessed From Bimanual Load-lifting Task: An Event-related Potential Study Neuroscience (IF 3.056) Pub Date : 2021-01-09 Carole Fortin; Fanny Barlaam; Marianne Vaugoyeau; Christine Assaiante
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Distortions of the Efferent Copy during Force Perception: A Study of Force Drifts and Effects of Muscle Vibration Neuroscience (IF 3.056) Pub Date : 2021-01-17 Cristian Cuadra; Jacob Corey; Mark L. Latash
We used a finger force matching task to explore the role of efferent signals in force perception. Healthy, young participants performed accurate force production tasks at different force levels with the index and middle fingers of one hand (task-hand). They received visual feedback during an early part of each trial only. After the feedback was turned off, the force drifted toward lower magnitudes
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Stress Resilience Is Associated with Hippocampal Synaptoprotection in the Female Rat Learned Helplessness Paradigm Neuroscience (IF 3.056) Pub Date : 2021-01-30 Orsolya Huzian; Judith Baka; Eszter Csakvari; Nikoletta Dobos; Csaba Leranth; Laszlo Siklos; Ronald S. Duman; Tamas Farkas; Tibor Hajszan
The synaptogenic hypothesis of major depressive disorder implies that preventing the onset of depressive-like behavior also prevents the loss of hippocampal spine synapses. By applying the psychoactive drugs, diazepam and fluoxetine, we investigated whether blocking the development of helpless behavior by promoting stress resilience in the rat learned helplessness paradigm is associated with a synaptoprotective
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Grasping and manipulation: neural bases and anatomical circuitry in humans Neuroscience (IF 3.056) Pub Date : 2021-01-29 Antonino Errante; Settimio Ziccarelli; Gloria Mingolla; Leonardo Fogassi
Neurophysiological and neuroimaging evidence suggests a significant contribution of several brain areas, including subdivisions of the parietal and the premotor cortex, during the processing of different components of hand and arm movements. Many investigations improved our knowledge about the neural processes underlying the execution of reaching and grasping actions, while few studies have directly
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Doing it wrong: a systematic review on electrocortical and behavioral correlates of error monitoring in patients with neurological disorders Neuroscience (IF 3.056) Pub Date : 2021-01-29 R. Pezzetta; M. Wokke; S.M. Aglioti; R. Ridderinkhof
Detecting errors in one’s own and other’s actions is a crucial ability for learning and adapting behavior to everchanging, highly volatile environments. Studies in healthy people demonstrate that monitoring errors in one’s own and others’ actions are underpinned by specific neural systems that are dysfunctional in a variety of neurological disorders. In this review, we first briefly discuss the main
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Sustained Hypoxia Reduces GABAergic Modulation on NTS Neurons Sending Projections to Ventral Medulla of Rats Neuroscience (IF 3.056) Pub Date : 2021-01-07 Júlio C. Pascoaloti-Lima; Benedito H. Machado; Daniela Accorsi-Mendonça
Peripheral chemoreflex is activated during short-term sustained hypoxia (SH), and the first synapse of these afferents is located in Nucleus Tractus Solitarius (NTS). NTS neurons projecting to the ventral lateral medulla (NTS-VLM) are part of the respiratory pathways of the chemoreflex. SH increases the magnitude of basal respiratory parameters in rats from Wistar-Hannover strain. In this study, we
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The Impact of FKBP5 Deficiency in Glucocorticoid Receptor Mediated Regulation of Synaptic Transmission in the Medial Prefrontal Cortex Neuroscience (IF 3.056) Pub Date : 2020-12-25 Hakyun Ryu; Myunghyun Cheon; ChiHye Chung
Exposure to stress activates glucocorticoid receptors in the brain and facilitates the onset of multitude psychiatric disorders. It has been shown that FK506 binding protein 51 (FKBP5) expression increases during glucocorticoid receptor (GR) activation in various brain regions including the medial prefrontal cortex (mPFC). FKBP5 knockout (KO) mice are reported to be resilient to stress, however, it
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Histamine and corticosterone modulate Acid sensing ion channels (ASICs) dependent long-term potentiation at the mouse anterior cingulate cortex Neuroscience (IF 3.056) Pub Date : 2021-01-23 María Natalia Gobetto; Carlota González-Inchauspe Osvaldo D. Uchitel
Increase in proton concentration [H+] or decrease in local and global extracellular pH occurs in both physiological and pathological conditions. Acid-sensing ion channels (ASICs), belonging to the ENaC/Deg superfamily, play an important role in signal transduction as proton sensor. ASICs and in particular ASIC-1a (one of the six ASICs subunits) which is permeable to Ca2+, are involved in many physiological
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Brain pH imaging and its applications Neuroscience (IF 3.056) Pub Date : 2021-01-23 Hahnsung Kim; Lisa C. Krishnamurthy; Phillip Zhe Sun
Acid-base homeostasis and pH regulation are critical for normal tissue metabolism and physiology, and brain tissue pH alters in many diseased states. Several noninvasive tissue pH Magnetic Resonance (MR) techniques have been developed over the past few decades to shed light on pH change during tissue function and dysfunction. Nevertheless, there are still challenges for mapping brain pH noninvasively
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Promotion of dendritic differentiation of cerebellar Purkinje cells by Ca2+/calmodulin-dependent protein kinase IIα, IIβ and IV and possible involvement of CREB phosphorylation Neuroscience (IF 3.056) Pub Date : 2021-01-23 Yuki Horie; Toshiaki Arame; Naohide Hirashima; Masahiko Tanaka
Cerebellar Purkinje cells develop the most elaborate dendritic trees among neurons in the brain. To examine the role of Ca2+/calmodulin-dependent protein kinase (CaMK) IIα, IIβ and IV in the dendritic differentiation of Purkinje cells, we introduced siRNA against these CaMKs into Purkinje cells in cerebellar cell cultures using a single-cell electroporation technique. Single-cell electroporation enables