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Spinal lymphatic dysfunction aggravates the recovery process after spinal cord injury Neuroscience (IF 3.3) Pub Date : 2024-03-08 Rui-Guang Zhang, Bo-Wen Zheng, Jing Zhang, Ming-yu Hao, Yu-Hang Diao, Xiao- Jun Hu, Xuan-Hui Liu, Tao Zhu, Zi-Long Zhao, Hong-Tao Rong
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Purinergic astrocyte signaling driven by TNF-α after cannabidiol administration restores normal synaptic remodeling following traumatic brain injury Neuroscience (IF 3.3) Pub Date : 2024-03-08 Tenghan Ling, Aiping Yin, Yan Cao, Jiali Li, Hengxi Li, Ying Zhou, Xiaobing Guo, Jinghui Li, Ruilin Zhang, Haiying Wu, Ping Li
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Revealing Novel Genes Related to Parkinson's Disease Pathogenesis and Establishing an associated Model Neuroscience (IF 3.3) Pub Date : 2024-03-07 Hao-wei Deng, Bin-ru Li, Shao-dan Zhou, Chun Luo, Bing-hua Lv, Zi-mei Dong, Chao Qin, Rui-ting Hu
Parkinson's disease (PD) represents a multifaceted neurological disorder whose genetic underpinnings warrant comprehensive investigation. This study focuses on identifying genes integral to PD pathogenesis and evaluating their diagnostic potential. Initially, we screened for differentially expressed genes (DEGs) between PD and control brain tissues within a dataset comprising larger number of specimens
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The Landscape of Publishing in Neuroscience: Honouring Our Scientific Heritage and Shaping the Future of Research Neuroscience (IF 3.3) Pub Date : 2024-03-05 Francesca Cirulli, Sarah J. Spencer, Chen Zhang
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Bilateral Whisker Representations in the Primary Somatosensory Cortex in Robo3cKO Mice Are Reflected in the Primary Motor Cortex Neuroscience (IF 3.3) Pub Date : 2024-03-05 Vassiliy Tsytsarev, Céline Plachez, Shuxin Zhao, Daniel H. O'Connor, Reha S. Erzurumlu
In Robo3cKO mice, midline crossing defects of the trigeminothalamic projections from the trigeminal principal sensory nucleus result in bilateral whisker maps in the somatosensory thalamus and consequently in the face representation area of the primary somatosensory (S1) cortex (Renier et al., 2017; Tsytsarev et al., 2017). We investigated whether this bilateral sensory representation in the whisker-barrel
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Greater Pattern Similarity between Mother Tongue and Second Language in the Right ATL Facilitates Understanding of Written Language Neuroscience (IF 3.3) Pub Date : 2024-03-05 Jie Dong, Hao Yan, Leilei Mei, Gang Wang, Jing Qu, Xinyi Liu, Shanshan Xu, Wenjing Jiang, Aoke Zheng, Genyi Feng
Previous research has mapped out the brain regions that respond to semantic stimuli presented visually and auditorily, but there is debate about whether semantic representation is modality-specific (only written or only spoken) or modality-invariant (both written and spoken). The mechanism of semantic representation underlying native (L1) and second language (L2) comprehension in different modalities
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Taming Complexity from the Interface: Simplifying Neuroscience Neuroscience (IF 3.3) Pub Date : 2024-03-05 I, g, o, r, , B, r, a, n, c, h, i
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Ischaemic Stroke, Thromboembolism and Clot Structure Neuroscience (IF 3.3) Pub Date : 2024-03-05 Katherine Stanton, Helen Philippou, Robert AS Ariëns
Ischaemic stroke is a major cause of morbidity and mortality worldwide. Blood clotting and thromboembolism play a central role in the pathogenesis of ischaemic stroke. An increasing number of recent studies indicate changes in blood clot structure and composition in patients with ischaemic stroke. In this review, we aim to summarise and discuss clot structure, function and composition in ischaemic
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Epigenetic Mechanism of SETD1B-mediated Histone Methylation in Cognitive Impairment Induced by Sevoflurane Anesthesia in Neonatal Mice Neuroscience (IF 3.3) Pub Date : 2024-03-04 Zhao Wang, Jing Zhang, Qian Tang, Yujie Tan
Sevoflurane (Sev) anesthesia is associated with cognitive deficits and neurotoxicity. This study explores the epigenetic mechanism of SET domain containing 1B (SETD1B) in Sev-induced cognitive impairment in neonatal mice. Neonatal mice (C57BL, = 72) were exposed to 3% Sev for 2 h per day at P6, 7, and 8, and the control neonatal mice were only separated from the mother for 2 h. The mice were divided
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Autokinesis Reveals a Threshold for Perception of Visual Motion Neuroscience (IF 3.3) Pub Date : 2024-03-02 Yihao Liu, Jing Tian, Alejandro Martin-Gomez, Qadeer Arshad, Mehran Armand, Amir Kheradmand
In natural viewing conditions, the brain can optimally integrate retinal and extraretinal signals to maintain a stable visual perception. These mechanisms, however, may fail in circumstances where extraction of a motion signal is less viable such as impoverished visual scenes. This can result in a phenomenon known as autokinesis in which one may experience apparent motion of a small visual stimulus
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Effects of Dietary Fiber on Short Chain Fatty Acid Receptor mRNA in Microglia and Serotonergic Neurons in the Mouse Brain Neuroscience (IF 3.3) Pub Date : 2024-02-29 Janna B. Hart, Robert K. Poon, Robert E. Ward, Korry J. Hintze, Sara M. Freeman
Short-chain fatty acids (SCFAs) are bioactive lipids that are released into the colon as a metabolite of bacterial fermentation of dietary fibers. Beyond their function in the gastrointestinal tract, SCFAs can also have effects inthe brain, as a part of the gut-brain axis. Recent investigations into potential therapeutic interventions via the manipulation of the gut microbiome—and thus their SCFA metabolites—has
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Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional Recovery in Mice with Mild Neurological Impairment after Intracerebral Hemorrhage Neuroscience (IF 3.3) Pub Date : 2024-02-29 Xiyao Wu, Zhiling Chen, Qiuming Chen, Chuangan Lin, Xiangrong Zheng, Bangqing Yuan
Neuregulin receptor degradation protein 1 (Nrdp1) is a ring finger E3 ubiquitin ligase involved in some inflammation through ubiquitination, including macrophage polarization following cerebral hemorrhage. However, there is limited understanding regarding the mechanisms through which Nrdp1 modulates macrophage polarization and the potential impact of this modulation on neurological function. Using
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BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended Neuroscience (IF 3.3) Pub Date : 2024-02-28 P, e, t, e, r, , A, ., , S, m, i, t, h
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The Interaction between ADK and SCG10 Regulate the Repair of Nerve Damage Neuroscience (IF 3.3) Pub Date : 2024-02-28 Tianjun Chen, Zhiwan Chen, Ping Wu, Jianxian Luo, Qiuling Liu, Hua Yang, Cheng Peng, Guowei Zhang, Hongsheng Lin, Zhisheng Ji
The cytoskeleton must be remodeled during neurite outgrowth, and Superior Cervical Ganglion 10 (SCG10) plays a critical role in this process by depolymerizing Microtubules (MTs), conferring highly dynamic properties to the MTs. However, the precise mechanism of action of SCG10 in the repair of injured neurons remains largely uncertain. Using transcriptomic identification, we discovered that SCG10 expression
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Electroacupuncture Enhances the Functional Connectivity of Limbic System to Neocortex in the 5xFAD Mouse Model of Alzheimer's Disease Neuroscience (IF 3.3) Pub Date : 2024-02-28 Mingzhu Xu, Run Lin, Huaneng Wen, Yixiao Wang, John Wong, Zhihua Peng, Lu Liu, Binbin Nie, Jing Luo, Xiaoyu Tang, Shaoyang Cui
Our previous study revealed that acupuncture may exhibit therapeutic effects on Alzheimer's disease (AD) through the activation of metabolism in memory-related brain regions. However, the underlying functional mechanism remains poorly understood and warrants further investigation. In this study, we used resting-state functional magnetic resonance imaging (rsfMRI) to explore the potential effect of
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Apoptosis Due to After-effects of Acute Ethanol Exposure in Brain Cortex: Intrinsic and Extrinsic Signaling Pathways Neuroscience (IF 3.3) Pub Date : 2024-02-28 Analía G. Karadayian, Analia Czerniczyniec, Silvia Lores-Arnaiz
Alcohol hangover is the combination of negative mental and physical symptoms which can be experienced after a single episode of alcohol consumption, starting when blood alcohol concentration approaches zero. We previously demonstrated that hangover provokes mitochondrial dysfunction, oxidative stress, imbalance in antioxidant defenses, and impairment in cellular bioenergetics. Chronic and acute ethanol
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Changes in Community Structure of Brain Dynamic Functional Connectivity States in Mild Cognitive Impairment Neuroscience (IF 3.3) Pub Date : 2024-02-28 Hongwei Wang, Zhihao Zhu, Hui Bi, Zhongyi Jiang, Yin Cao, Suhong Wang, Ling Zou
Recent researches have noted many changes of short-term dynamic modalities in mild cognitive impairment (MCI) patients' brain functional networks. In this study, the dynamic functional brain networks of 82 MCI patients and 85 individuals in the normal control (NC) group were constructed using the sliding window method and Pearson correlation. The window size was determined using single-scale time-dependent
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Neurometabolic and Brain Functional Alterations Associated with Cognitive Impairment in Patients with Myasthenia Gravis: A Combined 1H-MRS and fMRI Study Neuroscience (IF 3.3) Pub Date : 2024-02-28 Xiaoling Zhou, Yang Yang, Feng Zhu, Xiang Chen, Yunfei Zhu, Tiantian Gui, Yonggang Li, Qun Xue
Whether patients with myasthenia gravis (MG) exhibit cognitive impairment is controversial. Also the underlying mechanisms are unknown. We aimed to investigate alterations in cognitive function, neurometabolite levels, and brain function in patients with MG and to explore the associations between abnormal regional brain functional activity, neurometabolite concentrations in the MPFC and left thalamus
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Transient Receptor Potential Ankyrin 1-dependent Activation of Extracellular Signal-regulated Kinase 2 in the Cerebral Cortices Contributes to Cortical Spreading Depolarization Neuroscience (IF 3.3) Pub Date : 2024-02-27 Haoyang Li, Chenyi Wang, Ziyang Gong, Lingdi Nie, Jiaxin Xu, Minyan Wang
Extracellular signal-regulated kinase (ERK) are serine/threonine-selective proteins and ERK1/2 can be phosphorylated in peripheral and central brain regions after cortical spreading depolarization (CSD) and calcitonin gene-related peptide; However, it remains unclear about whether and how ERK activity modulates CSD that correlates to migraine aura. Here, we determined the role of ERK in regulating
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Immature Status Epilepticus Alters the Temporal Relationship between Hippocampal Interictal Epileptiform Discharges and High-frequency Oscillations Neuroscience (IF 3.3) Pub Date : 2024-02-23 Konstantinos Kalogeropoulos, Caterina Psarropoulou
The aim was to investigate the long-term effects of a single episode of immature Status Epilepticus (SE) on the excitability of the septal and temporal hippocampus , by studying the relationship between interictal-like epileptiform discharges (IEDs) and high-frequency oscillations (HFOs; Ripples, Rs and Fast Ripples, FRs). A pentylenetetrazol-induced Status Epilepticus-(SE)-like generalized seizure
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Corrigendum to “Age-dependent Effects of Dopamine on Working Memory and Synaptic Plasticity in Hippocampal CA3-CA1 Synapses in Mice” [Neuroscience 532 (2023) 14–22] Neuroscience (IF 3.3) Pub Date : 2024-02-23 Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Amir Shojaei, Yaghoub Fathollahi, Nahid Roohi, Vicrotia Barkley, Javad Mirnajafi-Zadeh
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Attentional Correlates of Colored Lights: Considerations for Cognitive Testing Neuroscience (IF 3.3) Pub Date : 2024-02-23 Vakode Vani, Pooja Ojha, Mahesh Arjundan Gadhvi, Abhinav Dixit
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Bioinformatics and Systems Biology Approaches to Identify the Synergistic Effects of Alcohol Use Disorder on the Progression of Neurological Diseases Neuroscience (IF 3.3) Pub Date : 2024-02-23 Md. Jahangir Alam, Md Habibur Rahman, Md. Arju Hossain, Md. Robiul Hoque, Md Aktaruzzaman
Clinical investigations showed that individuals with Alcohol Use Disorder (AUD) have worse Neurological Disease (ND) development, pointing to possible pathogenic relationships between AUD and NDs. It remains difficult to identify risk factors that are predisposing between AUD and NDs. In order to fix these issues, we created the bioinformatics pipeline and network-based approaches for employing unbiased
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Effects of gestational exercise on nociception, BDNF, and irisin levels in an animal model of ADHD Neuroscience (IF 3.3) Pub Date : 2024-02-22 Andréa Tosta, Ariene S. Fonseca, Débora Messender, Sérgio T. Ferreira, Mychael V. Lourenco, Pablo Pandolfo
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Sp1 Regulates the M1 Polarization of Microglia Through the HuR/NF-κB Axis after Spinal Cord Injury Neuroscience (IF 3.3) Pub Date : 2024-02-21 Hangyu Guo, Mingyu Du, Yang Yang, Xin Lin, Yufu Wang, Helin Li, Jiyu Ren, Wenbo Xu, Jinglong Yan, Nanxiang Wang
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NEW PERSPECTIVES IN NEUROPROTECTION FOR ISCHEMIC STROKE Neuroscience (IF 3.3) Pub Date : 2024-02-21 María Pérez-Mato, Esteban López-Arias, Ana Bugallo-Casal, Clara Correa-Paz, Susana Arias, Manuel Rodríguez-Yáñez, María Santamaría-Cadavid, Francisco Campos
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Sex-specific Differences in Resting Oscillatory Dynamics in Children with Prenatal Alcohol Exposure Neuroscience (IF 3.3) Pub Date : 2024-02-20 Felicha T. Candelaria-Cook, Megan E. Schendel, Lucinda L. Romero, Cassandra Cerros, Dina E. Hill, Julia M. Stephen
At rest children with prenatal alcohol exposure (PAE) exhibit impaired static and dynamic functional connectivity, along with decreased alpha oscillations. Sex-specific information regarding the impact of PAE on whole-brain resting-state gamma spectral power remains unknown. Eyes-closed and eyes-open MEG resting-state data were examined in 83 children, ages 6–13 years of age. Using a matched design
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MiR-10b-5p Regulates Neuronal Autophagy and Apoptosis Induced by Spinal Cord Injury Through UBR7 Neuroscience (IF 3.3) Pub Date : 2024-02-19 Shuangmei Liu, Huali Liu, Chunyan Gong, Guiliang Li, Qiaofen Li, Zhipeng Pan, Xiaona He, Zhilv Jiang, Heng Li, Chunjun Zhang
This study aimed to explore the effects of miR-10b-5p on autophagy and apoptosis in neuronal cells after spinal cord injury (SCI) and the molecular mechanism. Bioinformatics was used to analyze the differentially expressed miRNAs. The expression of related genes and proteins were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) and Western blot, respectively. Cell
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Functional and Structural Abnormalities in the Pain Network of Generalized Anxiety Disorder Patients with Pain Symptoms Neuroscience (IF 3.3) Pub Date : 2024-02-19 Jie Meng, Ting Zhang, Tong Hao, Xiaohui Xie, Mengdan Zhang, Lei Zhang, Xingsong Wan, Chunyan Zhu, Qianqian Li, Kai Wang
Pain symptoms significantly impact the well-being and work capacity of individuals with generalized anxiety disorder (GAD), and hinder treatment and recovery. Despite existing literature focusing on the neural substrate of pain and anxiety separately, further exploration is needed to understand the possible neuroimaging mechanisms of the pain symptoms in GAD patients. We recruited 73 GAD patients and
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Classification Algorithm for fNIRS-based Brain Signals Using Convolutional Neural Network with Spatiotemporal Feature Extraction Mechanism Neuroscience (IF 3.3) Pub Date : 2024-02-17 Yuxin Qin, Baojiang Li, Wenlong Wang, Xingbin Shi, Cheng Peng, Yifan Lu
This graphic shows the structure of our network. In the preprocessing section, we used the Beer-Lambert law to convert the optical signals into hemodynamic HbR and HbO. We used an end-to-end structure without much preprocessing of the raw fNIRS signal. We input the signal with the number of channels C = 24 and the number of samples T = 351. the original MI and MA signals are first passed through a
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Traditional Pediatric Massage Enhanced Hippocampal GR, BDNF and IGF-1 Expressions and Exerted an Anti-depressant Effect in an Adolescent Rat Model of CUMS-induced Depression Neuroscience (IF 3.3) Pub Date : 2024-02-15 Rong Wu, Ying Xiong, Yun Gu, Li-Yue Cao, Shu-Ying Zhang, Zhi-Xiu Song, Pu Fan, Lin Lin
This study aimed to investigate the anti-depressant effect of traditional pediatric massage (TPM) in adolescent rats and its possible mechanism. The adolescent depression model in rats was established by using chronic unpredictable mild stress (CUMS). All rats were randomly divided into 5 groups (7 per group), including the groups of control (CON), CUMS, CUMS with TPM, CUMS with back stroking massage
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Microglial Inflammatory Mechanisms in Stroke: The Jury Is Still Out Neuroscience (IF 3.3) Pub Date : 2024-02-15 Szilvia Benkő, Ádám Dénes
Microglia represent the main immune cell population in the CNS with unique homeostatic roles and contribution to broad neurological conditions. Stroke is associated with marked changes in microglial phenotypes and induction of inflammatory responses, which emerge as key modulators of brain injury, neurological outcome and regeneration. However, due to the limited availability of functional studies
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Simulated Chronic Jet Lag Affects the Structural and Functional Complexity of Hippocampal Neurons in Mice Neuroscience (IF 3.3) Pub Date : 2024-02-13 Ruchika Kumari, Vivek Verma, Muniyandi Singaravel
There has been a long history that chronic circadian disruption such as jet lag or shift work negatively affects brain and body physiology. Studies have shown that circadian misalignment act as a risk factor for developing anxiety and mood-related depression-like behavior. Till date, most studies focused on simulating jet lag in model animals under laboratory conditions by repeated phase advances or
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Foxp2 Is Required for Nucleus Accumbens-mediated Multifaceted Limbic Function Neuroscience (IF 3.3) Pub Date : 2024-02-12 Bo-Han He, Ya-Hui Yang, Bo-Wen Hsiao, Wan-Ting Lin, Yi-Fang Chuang, Shih-Yun Chen, Fu-Chin Liu
The forkhead box protein P2 (), initially identified for its role in speech and language development, plays an important role in neural development. Previous studies investigated the function of the gene by deleting or mutating from developmental stages. Little is known about its physiological function in adult brains. Although has been well studied in the dorsal striatum, its function in the nucleus
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The Neuroprotective Effects of BMSC-Derived Exosomes against Glutamate-Induced HT22 Cell Cytotoxicity Neuroscience (IF 3.3) Pub Date : 2024-02-10 Jingtong Rong, Siqi Sun, Shu-xian Xu, Xin-hui Xie, Chao Wang, Guopeng Chen, Lijun Kang, Dan Xiang, Zhongchun Liu
Many central nervous system diseases are closely related to nerve damage caused by dysregulation of the endogenous neurotransmitter glutamate. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) play an important role in improving injury and regeneration functions. However, its mechanism remains unknown. Therefore, the aim of this study is to investigate whether and how BMSC-Exos improve
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Maresin 1 Activates LGR6 to Alleviate Neuroinflammation via the CREB/JMJD3/IRF4 Pathway in a Rat Model of Subarachnoid Hemorrhage Neuroscience (IF 3.3) Pub Date : 2024-02-08 Zhenyan Li, Wen Yuan, Xian Yang, Juan Jiang, Qi-Lei Zhang, Xiao-Xin Yan, Yu-Chun Zuo
Proposed pathway of maresin 1 attenuated neuroinflammation after SAH in rat models. Neuroinflammation was characterized by microglial activation and neutrophils infiltration after SAH. The maresin 1 administration could activate LGR6 receptor, which further activated CREB/JMJD3/IRF4 signaling pathway and decrease the pro-inflammatory cytokines IL-1β, IL-6 while increase the anti-inflammatory cytokine
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Acute Administration of Lactate Exerts Antidepressant-like Effect Through cAMP-dependent Protein Synthesis Neuroscience (IF 3.3) Pub Date : 2024-02-08 Liang Zhang, Jing Zheng, Shi-Yan Liu, Li-Li Hou, Bo Zhang, Shao-Wen Tian
Lactate acts as an important metabolic substrate and signalling molecule modulating neural activities in the brain, and recent preclinical and clinical studies have revealed its antidepressant effect after acute or chronic peripheral administration. However, the neural mechanism underlying the antidepressant effect of lactate, in particular when lactate is acutely administered remains largely unknown
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Effect of a territorial challenge on the steroid profile of a juvenile songbird Neuroscience (IF 3.3) Pub Date : 2024-01-30 Sofia L. Gray, Emma K. Lam, L. Francisco Henao-Diaz, Cecilia Jalabert, Kiran K. Soma
Aggression is a social behavior that is critical for survival and reproduction. In adults, circulating gonadal hormones, such as androgens, act on neural circuits to modulate aggressive interactions, especially in reproductive contexts. In many species, individuals also demonstrate aggression before reaching gonadal maturation. Adult male song sparrows, Melospiza melodia, breed seasonally but maintain
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A Novel Framework for Epileptic Seizure Detection using Electroencephalogram Signals based on the Bat Feature Selection Algorithm Neuroscience (IF 3.3) Pub Date : 2024-01-30 Mahrad Pouryosef, Roozbeh Abedini-Nassab, Seyed Mohammad Reza Akrami
The precise electroencephalogram (EEG) signal classification with the highest possible accuracy is a key goal in the brain-computer interface (BCI). Considering the complexity and nonstationary nature of the EEG signals, there is an urgent need for effective feature extraction and data mining techniques. Here, we introduce a novel pipeline based on Bat and genetic algorithms for feature construction
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Mineralocorticoid Receptor Antagonism Reduces Inflammatory Pain Measures in Mice Independent of the Receptors on Sensory Neurons Neuroscience (IF 3.3) Pub Date : 2024-02-02 Katherine A. Qualls, Wenrui Xie, Jietong Zhang, Debora Denardin Lückemeyer, Sierra V. Lackey, Judith A. Strong, Jun-Ming Zhang
Corticosteroids are commonly used in the treatment of inflammatory low back pain, and their nominal target is the glucocorticoid receptor (GR) to relieve inflammation. They can also have similar potency at the mineralocorticoid receptor (MR). The MR has been shown to be widespread in rodent and human dorsal root ganglia (DRG) neurons and non-neuronal cells, and when MR antagonists are administered
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Faecal Microbiota Transplantation Alleviates Ferroptosis after Ischaemic Stroke Neuroscience (IF 3.3) Pub Date : 2024-01-29 Jinzhen Wei, Gang Wang, Min Lai, Yipin Zhang, Fengru Li, Yongwang Wang, Yongxing Tan
Ischaemic stroke can induce changes in the abundance of gut microbiota constituents, and the outcome of stroke may also be influenced by the gut microbiota. This study aimed to determine whether gut microbiota transplantation could rescue changes in the gut microbiota and reduce ferroptosis after stroke in rats. Male Sprague-Dawley rats (6 weeks of age) were subjected to ischaemic stroke by middle
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Ischemic Stroke: From Fibrinolysis to Functional Recovery Neuroscience (IF 3.3) Pub Date : 2024-02-01 Carine Ali, Denis Vivien
Abstract not available
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Brain Source Localization and Functional Connectivity in Group Identity Regulation of Overbidding in Contest Neuroscience (IF 3.3) Pub Date : 2024-02-01 Qing Xin, Su Hao, Wang Xiaoqin, Pan Jiali
Contests may be highly effective in eliciting high levels of effort, but they also carry the risk of inefficient resource allocation due to excessive effort (overbidding), squandering valuable social resources. While a growing body of research has focused on how group identity exacerbates out-group conflict, its influence on in-group conflict remains relatively unexplored. This study endeavors to explore
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Glutamatergic Projection from the Ventral Tegmental Area to the Zona Incerta Regulates Fear Response Neuroscience (IF 3.3) Pub Date : 2024-01-26 Xin-Yi Wang, Hong-Quan Zhang, Kun Tong, Jie Han, Xin-Yu Zhao, Yu-Tong Song, Jing-Ru Hao, Nan Sun, Can Gao
Innate defensive behavior is important for animal survival. The Vglut2+ neurons in the ventral tegmental area (VTA) have been demonstrated to play important roles in innate defensive behaviors, but the neural circuit mechanism is still unclear. Here, we find that VTA - zona incerta (ZI) glutamatergic projection is involved in regulating innate fear responses. Combining calcium signal recording and
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Ethanol differentially affects excitatory and inhibitory synaptic transmission in visual cortex of wild-type and adenosine A1R knock-out mice Neuroscience (IF 3.3) Pub Date : 2024-01-24 Noah Raffone, Marina Chistiakova, Maxim Volgushev
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Resveratrol improves cognitive function in post-stroke depression rats by repressing inflammatory reactions and oxidative stress via the Nrf2/HO-1 pathway Neuroscience (IF 3.3) Pub Date : 2024-01-24 Yanjuan Bai, Rubo Sui, Lei Zhang, Bing Bai, Yue Zhu, Hongxin Jiang
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Effects of cardiac glycoside digoxin on dendritic spines and motor learning performance in mice Neuroscience (IF 3.3) Pub Date : 2024-01-24 Junichi Hashimoto, Erika Fujita, Keisuke Tanimoto, Suzuo Kondo, Kazumasa Matsumoto-Miyai
Synapse formation following the generation of postsynaptic dendritic spines is essential for motor learning and functional recovery after brain injury. The C-terminal fragment of agrin cleaved by neurotrypsin induces dendritic spine formation in the adult hippocampus. Since the α3 subunit of sodium-potassium ATPase (Na/K ATPase) is a neuronal receptor for agrin in the central nervous system, cardiac
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Remembrances of Dr. Michael V.L. Bennett by Iberoamerican Colleagues and Friends Neuroscience (IF 3.3) Pub Date : 2024-01-23 Verónica Abudara, Ricardo C. Araneda, Luis Barrio, Viviana M. Berthoud, Jorge E. Contreras, Eliseo Eugenín, Juan Lerma, Juan A. Orellana, Nicolás Palacios-Prado, Martha Pérez-Armendariz, Mauricio A. Retamal, Juan C. Sáez
Abstract not available
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Intracerebroventricular Cutibacterium acnes generates manifestations of Alzheimer's disease-like pathology in the rat hippocampus Neuroscience (IF 3.3) Pub Date : 2024-01-23 Morteza Aliashrafi, Mohammad Nasehi, Mohammad-Reza Zarrindast, Mohammad-Taghi Joghataei, Hakimeh Zali, Seyed Davar Siadat
The infection hypothesis is a new causative explanation for Alzheimer's disease (AD). In recent decades, various species of bacterial pathogens have been distinguished in the autopsy of Alzheimer's patients; however, the mechanism of bacterial contribution to AD pathology is still unknown. To explore the hypothesis, Cutibacterium acnes (C. acnes) was selected, and effects of its intracerebroventricular
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Proteomic Characteristics of the Prefrontal Cortex and Hippocampus in Mice with Chronic Ketamine-Induced Anxiety and Cognitive Impairment Neuroscience (IF 3.3) Pub Date : 2024-01-23 Li Xiao, Ying Wei, Hong Yang, Weihao Fan, Linzhi Jiang, Yi Ye, Yongping Qin, Xia Wang, Chunling Ma, Linchuan Liao
Schizophrenia, a complex psychiatric disorder with diverse symptoms, has been linked to ketamine, known for its N-methyl-D-aspartate (NMDA) receptor antagonistic properties. Understanding the distinct roles and mechanisms of ketamine is crucial, especially regarding its induction of schizophrenia-like symptoms. Recent research highlights the impact of ketamine on key brain regions associated with schizophrenia
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Common Sequential Organization of Face Processing in the Human Brain and Convolutional Neural Networks Neuroscience (IF 3.3) Pub Date : 2024-01-23 Wenlu Li, Jin Li, Congying Chu, Dan Cao, Weiyang Shi, Yu Zhang, Tianzi Jiang
Face processing includes two crucial processing levels – face detection and face recognition. However, it remains unclear how human brains organize the two processing levels sequentially. While some studies found that faces are recognized as fast as they are detected, others have reported that faces are detected first, followed by recognition. We discriminated the two processing levels on a fine time
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Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis Neuroscience (IF 3.3) Pub Date : 2024-01-23 Lulu Ren, Huazheng Liang, Li Zhu, Xiao Yang, Hong Zhang, Nianyi Sun, Dunbing Huang, Jing Feng, Yufeng Wu, Lize Xiong, Xiaohua Ke, Min Li, Anren Zhang
Anesthesia/surgery have been identified as potential factors contributing to perioperative neurocognitive disorders, with a notably heightened risk observed in aging populations. One of the primary drivers of this impairment is believed to be neuroinflammation, specifically inflammation of hippocampal microglia. Dietary restriction has demonstrated a favorable impact on cognitive impairment across
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Reorganization of Brain Resting-state Functional Connectivity Following 14 Days of Elbow Immobilization in Young Females Neuroscience (IF 3.3) Pub Date : 2024-01-19 Julien Clouette, Alexandra Potvin-Desrochers, Freddie Seo, Tyler A. Churchward-Venne, Caroline Paquette
Limb immobilization is known to cause significant decreases in muscle strength and muscle mass as early as two days following the onset of immobilization. However, the decline in strength surpasses the decline in muscle mass, suggesting that factors in addition to muscle loss, such as neuroplasticity, contribute to the decrease in force production. However, little is known regarding immobilization-induced
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Secretory Clusterin Inhibits Dopamine Neuron Apoptosis in MPTP Mice by Preserving Autophagy Activity Neuroscience (IF 3.3) Pub Date : 2024-01-17 Dongxue Zhu, Shenyang Zhang, Xiaoying Wang, Chenghua Xiao, Guiyun Cui, Xinxin Yang
Secretory clusterin (sCLU) plays an important role in the research progress of nervous system diseases. However, the physiological function of sCLU in Parkinson's disease (PD) are unclear. The purpose of this study was to examine the effects of sCLU-mediated autophagy on cell survival and apoptosis inhibition in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. We found
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In-vitro Approaches to Investigate the Detrimental Effect of Light on Dopaminergic Neurons Neuroscience (IF 3.3) Pub Date : 2024-01-18 Irene Fasciani, Francesco Petragnano, Federica Bono, Gabriella Aloisi, Veronica Mutti, Carla Pardini, Marco Carli, Marco Scarselli, Francesca Vaglini, Adriano Angelucci, Chiara Fiorentini, Luca Lozzi, Cristina Missale, Roberto Maggio, Mario Rossi
Our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to the development of typical histological characteristics associated with Parkinson’s disease such as the loss of dopamine neurons in the substantia nigra. Monochromatic LED lights were thus used in this work to deepen our knowledge on the effects of the major wavelength peaks of fluorescent
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Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by Competitively Binding miR-1-3p to Regulate ORC6 Expression Neuroscience (IF 3.3) Pub Date : 2024-01-18 Ge Zhang, Xiang Tao, Bao-wei Ji, Jie Gong
Glioma is one of the most common and difficult to cure malignant primary tumors of the central nervous system. Long non-coding RNA (lncRNA) has been reported to play important functions in biological processes of many tumors, including glioma. In our study, we aimed to reveal the role and molecular mechanisms of lncRNA COX10-AS1 in regulating the progression of glioma. First of all, we showed that
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Effect of the Novel Free Radical Scavenger 4′-Hydroxyl-2-Substituted Phenylnitronyl Nitroxide on Oxidative Stress, Mitochondrial Dysfunction and Apoptosis Induced by Cerebral Ischemia–Reperfusion in Rats Neuroscience (IF 3.3) Pub Date : 2024-01-17 Jun Qian, Tao Liang, Yu Xu, Zhi-Peng Liu, Lin-Lin Jing, Hong-Bo Luo
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Hippocampal trauma memory processing conveying susceptibility to traumatic stress Neuroscience (IF 3.3) Pub Date : 2024-01-12 Bart C.J. Dirven, Lennart van Melis, Teya Daneva, Lieke Dillen, Judith R. Homberg, Tamas Kozicz, Marloes J.A.G. Henckens
While the majority of the population is ever exposed to a traumatic event during their lifetime, only a fraction develops posttraumatic stress disorder (PTSD). Disrupted trauma memory processing has been proposed as a core factor underlying PTSD symptomatology. We used transgenic Targeted-Recombination-in-Active-Populations (TRAP) mice to investigate potential alterations in trauma-related hippocampal