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Brain Age of Rhesus Macaques over the Lifespan Neurobiol. Aging (IF 4.2) Pub Date : 2024-03-09 Yang S. Liu, Madhura Baxi, Christopher R. Madan, Kevin Zhan, Nikolaos Makris, Douglas L. Rosene, Ronald J. Killiany, Suheyla Cetin-Karayumak, Ofer Pasternak, Marek Kubicki, Bo Cao
Through the application of machine learning algorithms to neuroimaging data the brain age methodology was shown to provide a useful individual-level biological age prediction and identify key brain regions responsible for the prediction. In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain
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The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank Neurobiol. Aging (IF 4.2) Pub Date : 2024-03-04 María Rodriguez-Ayllon, Alexander Neumann, Amy Hofman, Meike W. Vernooij, Julia Neitzel
Physical activity is a protective factor against brain atrophy, while loss of brain volume could also be a determinant of physical activity. Therefore, we aimed to explore the bidirectional association of physical activity with brain structures in middle-aged and older adults from the UK Biobank. Overall, 3027 participants (62.45 ± 7.27 years old, 51.3% females) had data at two time points. Hippocampal
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Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults Neurobiol. Aging (IF 4.2) Pub Date : 2024-03-02 Lisa Bransby, Nawaf Yassi, Emily Rosenich, Rachel Buckley, Qiao-Xin Li, Paul Maruff, Matthew Pase, Yen Ying Lim
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report
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Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology Neurobiol. Aging (IF 4.2) Pub Date : 2024-03-02 Francisco C. Almeida, Tiago Jesus, Ana Coelho, Miguel Quintas-Neves, Kathryn Gauthreaux, Merilee A. Teylan, Charles N. Mock, Walter A. Kukull, John F. Crary, Tiago Gil Oliveira
Psychosis in Alzheimer’s Disease (AD) is prevalent and indicates poor prognosis. However, the neuropathological, cognitive and brain atrophy patterns underlying these symptoms have not been fully elucidated. In this study, we evaluated 178 patients with AD neuropathological change (ADNC) and ante-mortem volumetric brain magnetic resonance imaging (MRI). Presence of psychosis was determined using the
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Differences In Scalp-To-Cortex Tissues Across Age Groups, Sexes And Brain Regions: Implications For Neuroimaging And Brain Stimulation Techniques Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-29 Sybren Van Hoornweder, Marc Geraerts, Stefanie Verstraelen, Marten Nuyts, Kevin A. Caulfield, Raf Meesen
Aging affects the scalp-to-cortex distance (SCD) and the comprising tissues. This is crucial for noninvasive neuroimaging and brain stimulation modalities as they rely on traversing from the scalp to the cortex or vice versa. The specific relationship between aging and these tissues has not been comprehensively investigated. We conducted a study on 250 younger and older adults to examine age-related
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The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-28 Susanna Lopez, Harald Hampel, Patrizia Andrea Chiesa, Claudio Del Percio, Giuseppe Noce, Roberta Lizio, Stefan J. Teipel, Martin Dyrba, Gabriel González-Escamilla, Hovagim Bakardjian, Enrica Cavedo, Simone Lista, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J. Grothe, Marie-Claude Potier, Fabrizio Stocchi, Raffaele Ferri, Marie-Odile Habert, Bruno Dubois, Claudio Babiloni, INSIGHT-preAD
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer’s disease amyloidosis. This exploratory study in 161 SMC participants tested the relationships between those rhythms and seed-based resting-state functional magnetic resonance imaging (rs-fMRI)
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Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-23 Alexandra M. Gaynor, Yunglin Gazes, Caleb R. Haynes, Reshma S. Babukutty, Christian Habeck, Yaakov Stern, Yian Gu
Greater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance
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Personality traits and cognitive reserve—High openness benefits cognition in the presence of age-related brain changes Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-22 Annabell Coors, Seonjoo Lee, Christian Habeck, Yaakov Stern
Cognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19–80 years for cross-sectional (N=399) and longitudinal (N=273, mean
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Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-16 James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismail
Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer’s Disease Neuroimaging Initiative
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Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-16 Chu-Yun Xiao, Ya-Hui Ma, Yong-Li Zhao, Jia-Yao Liu, Lan Tan
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the Alzheimer’s Disease Neuroimaging Initiative were investigated. Peripheral blood was obtained, and magnetic resonance imaging was performed to measure cerebral microbleeds (CMB), lacunar infarctions (LI), and white matter hyperintensities (WMH). Multivariable-adjusted
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Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-16 Ebru Yıldırım, Tuba Aktürk, Lütfü Hanoğlu, Görsev Yener, Claudio Babiloni, Bahar Güntekin
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EEG delta and theta responses in patients with PDD, DLB, and Alzheimer's disease dementia (ADD). During visual and auditory oddball
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Associations of brain morphology with cortical proteins of cognitive resilience Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-15 Victoria N. Poole, Abdur R. Ridwan, Konstantinos Arfanakis, Robert J. Dawe, Nicholas T. Seyfried, Philip L. De Jager, Julie A. Schneider, Sue E. Leurgans, Lei Yu, David A. Bennett
In a recent proteome-wide study, we identified several candidate proteins for drug discovery whose cortical abundance was associated with cognitive resilience to late-life brain pathologies. This study examines the extent to which these proteins are associated with the brain structures of cognitive resilience in decedents from the Religious Orders Study and Memory and Aging Project. Six proteins were
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Age-related differences in perception and coding of attractive odorants in mice Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-15 Laura Chalençon, Maëllie Midroit, Anna Athanassi, Marc Thevenet, Marine Breton, Jérémy Forest, Marion Richard, Anne Didier, Nathalie Mandairon
Hedonic perception deeply changes with aging, significantly impacting health and quality of life in elderly. In young adult mice, an odor hedonic signature is represented along the antero-posterior axis of olfactory bulb, and transferred to the olfactory tubercle and ventral tegmental area, promoting approach behavior. Here, we show that while the perception of unattractive odorants was unchanged in
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Physical activity-related individual differences in functional human connectome are linked to fluid intelligence in older adults Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-08 Dominika M. Pindus, Meishan Ai, Laura Chaddock-Heyman, Agnieszka Z. Burzynska, Neha P. Gothe, Elizabeth A. Salerno, Jason Fanning, Sheeba R.A. Arnold Anteraper, Alfonso N. Castanon, Susan Whitfield-Gabrieli, Charles H. Hillman, Edward McAuley, Arthur F. Kramer
The study examined resting state functional connectivity (rs-FC) associated with moderate-to-vigorous physical activity (MV-PA), sedentary time (ST), TV viewing, computer use, and their relationship to cognitive performance in older adults. We used pre-intervention data from 119 participants from the Fit & Active Seniors trial. Multivariate pattern analysis revealed two seeds associated with MV-PA:
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Volume electron microscopy reveals age-related ultrastructural differences of globular bush cell axons in mouse central auditory system Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-05 Wen-Qing Huang, Haibin Sheng, Haoyu Wang, Yumeng Qi, Fangfang Wang, Yunfeng Hua
In mammals, thick axonal calibers wrapped with heavy myelin sheaths are prevalent in the auditory nervous system. These features are crucial for fast traveling of nerve impulses with minimal attenuation required for sound signal transmission. In particular, the long-range projections from the cochlear nucleus – the axons of globular bush cells (GBCs) – to the medial nucleus of the trapezoid body (MNTB)
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Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-05 Nina Karalija, Goran Papenberg, Jarkko Johansson, Anders Wåhlin, Alireza Salami, Micael Andersson, Jan Axelsson, Dmitry Kuznetsov, Katrine Riklund, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Lars Nyberg
Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: = 181, age: 64–68 years; 5-year follow-up: = 129) who underwent positron emission tomography with C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic
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Data-driven analysis of regional brain metabolism in behavioral frontotemporal dementia and late-onset primary psychiatric diseases with frontal lobe syndrome: a PET/MRI study Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-03 Annachiara Cagnin, Giorgio Pigato, Ilaria Pettenuzzo, Giovanni Zorzi, Beatrice Roiter, Maria Giulia Anglani, Cinzia Bussè, Stefano Mozzetta, Carlo Gabelli, Cristina Campi, Diego Cecchin
Late-onset primary psychiatric disease (PPD) and behavioral frontotemporal dementia (bvFTD) present with a similar frontal lobe syndrome. We compare brain glucose metabolism in bvFTD and late-onset PPD and investigate the metabolic correlates of cognitive and behavioral disturbances through FDG-PET/MRI.
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Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-02 Adriana L. Ruiz-Rizzo, Kathrin Finke, Jessica S. Damoiseaux, Claudia Bartels, Katharina Buerger, Nicoleta Carmen Cosma, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Ingo Frommann, Wenzel Glanz, Doreen Goerss, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Debora Melo van Lent, Matthias H.J. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Ayda
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The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-02 Belfin Robinson, Shankar Bhamidi, Eran Dayan
Synergies between amyloid-β (Aβ), tau, and neurodegeneration persist along the Alzheimer’s disease (AD) continuum. This study aimed to evaluate the extent of spatial coupling between tau and neurodegeneration (atrophy) and its relation to Aβ positivity in mild cognitive impairment (MCI). Data from 409 participants were included (95 cognitively normal controls, 158 Aβ positive (Aβ+) MCI, and 156 Aβ
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RESTING STATE ELECTROENCEPHALOGRAPHIC ALPHA RHYTHMS ARE SENSITIVE TO ALZHEIMER’S DISEASE MILD COGNITIVE IMPAIRMENT PROGRESSION AT A 6-MONTH FOLLOW-UP Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-02 Claudio Babiloni, Dharmendra Jakhar, Federico Tucci, Claudio Del Percio, Susanna Lopez, Andrea Soricelli, Marco Salvatore, Raffaele Ferri, Valentina Catania, Federico Massa, Dario Arnaldi, Francesco Famà, Bahar Güntekin, Görsev Yener, Fabrizio Stocchi, Laura Vacca, Moira Marizzoni, Franco Giubilei, Ebru Yıldırım, Lutfu Hanoğlu, Duygu Hünerli Gündüz, Giovanni B. Frisoni, Giuseppe Noce
Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer’s disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up?
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Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice Neurobiol. Aging (IF 4.2) Pub Date : 2024-02-02 Claire Terrier, Juliette Greco-Vuilloud, Matthias Cavelius, Marc Thevenet, Nathalie Mandairon, Anne Didier, Marion Richard
Brain functional and structural changes lead to cognitive decline during aging, but a high level of cognitive stimulation during life can improve cognitive performances in the older adults, forming the cognitive reserve. Noradrenaline has been proposed as a molecular link between environmental stimulation and constitution of the cognitive reserve. Taking advantage of the ability of olfactory stimulation
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Contributions of Mouse Genetic Strain Background to Age-Related Phenotypes in Physically Active HET3 Mice Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-30 Jake W. Willows, Zahra Alshahal, Naeemah M. Story, Michele J. Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I. Stanford, Juan Peng, Peter C. Reifsnyder, David E. Harrison, W. David Arnold, Kristy L. Townsend
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APOE-ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-26 Paul Mick, Rasel Kabir, Malshi Karunatilake, M. Kathleen Pichora-Fuller, Terry-Lyn Young, Yuri Sosero, Ziv Gan-or, Walter Wittich, Natalie A. Phillips
Introduction Hearing loss and diminished visual acuity are associated with poorer cognition, but the underlying mechanisms are not understood. The apolipoprotein (APOE) ε4 allelic variant may drive the associations. We tested whether APOE-ε4 allele count (0, 1, or 2) was associated with declines in memory, executive function, pure-tone hearing threshold averages, and pinhole-corrected visual acuity
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Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-26 Lindsey Power, Alon Friedman, Timothy Bardouille
Paroxysmal patterns of slow cortical activity have been detected in EEG recordings from individuals with age-related neuropathology and have been shown to be correlated with cognitive dysfunction and blood-brain barrier disruption in these participants. The prevalence of these events in healthy participants, however, has not been studied. In this work, we inspect MEG recordings from 623 healthy participants
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A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-24 Ethan T. Whitman, Calen P. Ryan, Wickliffe C. Abraham, Angela Addae, David L. Corcoran, Maxwell L. Elliott, Sean Hogan, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Richie Poulton, Sandhya Ramrakha, Karen Sugden, Benjamin S. Williams, Jiayi Zhou, Ahmad R. Hariri, Daniel W. Belsky, Terrie E. Moffitt, Avshalom Caspi
Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. Here, we tested for associations between DunedinPACE and structural MRI phenotypes in three datasets spanning midlife to advanced age:
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Perivascular space burden interacts with APOE-ε4 status on cognition in older adults Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-22 Marissa A. Gogniat, Omair A. Khan, Corey W. Bown, Dandan Liu, Kimberly R. Pechman, L. Taylor Davis, Katherine A. Gifford, Bennett A. Landman, Timothy J. Hohman, Angela L. Jefferson
Enlarged perivascular spaces (ePVS) may adversely affect cognition. Little is known about how basal ganglia ePVS interact with apolipoprotein (APOE)-ε4 status. Vanderbilt Memory and Aging Project participants (n = 326, 73 ± 7, 59% male) underwent 3 T brain MRI at baseline to assess ePVS and longitudinal neuropsychological assessments. The interaction between ePVS volume and APOE-ε4 carrier status was
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Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-20 Chandlyr M. Denaro, Catherine L. Reed, Jasmin Joshi, Astrid Petropoulos, Anjali Thapar, Alan A. Hartley
We explored neural processing differences associated with aging across four cognitive functions. In addition to ERP analysis, we included task-related microstate analyses, which identified stable states of neural activity across the scalp over time, to explore whole-head neural activation differences. Younger and older adults (YA, OA) completed face perception (N170), word-pair judgment (N400), visual
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Brain structural indicators of β-amyloid neuropathology Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-18 Ikbeom Jang, Binyin Li, Barnaly Rashid, John Jacoby, Susie Y. Huang, Bradford C Dickerson, David H. Salat
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Exploring graded profiles of hippocampal atrophy along the anterior-posterior axis in semantic dementia and Alzheimer’s disease Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-12 Fang Lan, Daniel Roquet, Marshall A. Dalton, Hashim El-Omar, Rebekah M. Ahmed, Olivier Piguet, Muireann Irish
Mounting evidence indicates marked hippocampal degeneration in semantic dementia (SD) however, the spatial distribution of hippocampal atrophy profiles in this syndrome remains unclear. Using a recently developed parcellation approach, we extracted hippocampal volumes from four distinct subregions running from anterior to posterior along the longitudinal axis (anterior, intermediate rostral, intermediate
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Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-12 E. Suryana, B.D. Rowlands, D.P. Bishop, D.I. Finkelstein, K.L. Double
Metal dyshomeostasis is associated with neurodegenerative disorders, cancers and vascular disease. We report the effects of age (range: 3 to 18 months) on regional copper, iron and zinc levels in the brain of the C57BL/6 mouse, a widely used inbred strain with a permissive background allowing maximal expression of mutations in models that recapitulate these disorders. We present formulae that can be
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Electrophysiological alterations during action semantic processing in Parkinson’s disease Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-10 Mariano N. Díaz Rivera, Lucía Amoruso, Yamile Bocanegra, Jazmin X. Suárez, Leonardo Moreno, Edinson Muñoz, Agustina Birba, Adolfo M. García
Assessments of action semantics consistently reveal markers of Parkinson’s disease (PD). However, neurophysiological signatures of the domain remain under-examined in this population, especially under conditions that allow patients to process stimuli without stringent time constraints. Here we assessed event-related potentials and time-frequency modulations in healthy individuals (HPs) and PD patients
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Vascular risk burden is a key player in the early progression of Alzheimer’s disease Neurobiol. Aging (IF 4.2) Pub Date : 2024-01-10 João Pedro Ferrari-Souza, Wagner S. Brum, Lucas A. Hauschild, Lucas U. Da Ros, Pâmela C.L. Ferreira, Bruna Bellaver, Douglas T. Leffa, Andrei Bieger, Cécile Tissot, Firoza Z. Lussier, Marco Antônio De Bastiani, Guilherme Povala, Andréa L. Benedet, Joseph Therriault, Yi-Ting Wang, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Sheila O. Martins, Diogo O. Souza, Pedro Rosa-Neto, Thomas K. Karikari
Understanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's disease (AD) progression is important in the context of emerging treatments for preclinical AD. In a group of 503 cognitively unimpaired individuals, we tested whether VRF burden interacts with AD pathophysiology to accelerate neurodegeneration and cognitive decline. Baseline VRF burden was calculated considering
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Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-31 Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Bao
Alzheimer's disease (AD) is more prevalent in women than men, supposing due to the decline of estrogens in menopause, accompanied by increased gonadotropins such as luteinizing hormone (LH). We and others found that the transcription factor early growth response-1 (EGR1) regulates cholinergic function including the expression of acetylcholinesterase (AChE) and plays a significant role in cognitive
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Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-27 Mathilde Suhr Hemminghyth, Luiza Jadwiga Chwiszczuk, Monica Haraldseid Breitve, Berglind Gísladóttir, Gøril Rolfseng Grøntvedt, Arne Nakling, Arvid Rongve, Tormod Fladby, Bjørn-Eivind Kirsebom
Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a marker of neuronal body injury) and neurofilament light chain (NfL, a marker of axonal injury) show age-related increases in normal aging. In the current study, we aimed to investigate
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Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-29 Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huang
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Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-19 Fedor Levin, Michel J. Grothe, Martin Dyrba, Nicolai Franzmeier, Stefan J. Teipel
Previous studies have demonstrated resilience to AD-related neuropathology in a form of cognitive reserve (CR). In this study we investigated a relationship between CR and hypometabolic subtypes of AD, specifically the typical and the limbic-predominant subtypes. We analyzed data from 59 Aβ-positive cognitively normal (CN), 221 prodromal Alzheimer’s disease (AD) and 174 AD dementia participants from
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The effect of exercise on blood concentrations of angiogenesis markers in older adults: A systematic review and meta-analysis Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-19 Bing Xin Song, Laiba Azhar, Grace Ka Yi Koo, Susan Marzolini, Damien Gallagher, Walter Swardfager, Clara Chen, Joycelyn Ba, Nathan Herrmann, Krista L. Lanctôt
Impaired angiogenesis is associated with cognitive decline in older adults. While exercise has been broadly associated with increased angiogenesis, the relevant mechanisms in older adults are not clear. Here, we present a systematic review and meta-analysis on the relationship between exercise and specific blood angiogenesis markers in older adults to better understand the relevant mechanisms. MEDLINE
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Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-10 Nick Corriveau-Lecavalier, Nirubol Tosakulwong, Timothy G. Lesnick, Angela J. Fought, Robert I. Reid, Christopher G. Schwarz, Matthew L. Senjem, Clifford R. Jack, David T. Jones, Prashanthi Vemuri, Rosa Rademakers, Eliana Marisa Ramos, Daniel H. Geschwind, David S. Knopman, Hugo Botha, Rodolfo Savica, Jonathan Graff-Radford, Vijay K. Ramanan, Julie A. Fields, Neill Graff-Radford, Kejal Kantarci
We assessed white matter (WM) integrity in MAPT mutation carriers (16 asymptomatic, 5 symptomatic) compared to 31 non-carrier family controls using diffusion tensor imaging (DTI) (fractional anisotropy; FA, mean diffusivity; MD) and neurite orientation dispersion and density imaging (NODDI) (neurite density index; NDI, orientation and dispersion index; ODI). Linear mixed-effects models accounting for
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Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-12 Mohammad Taghvaei, Dawn J. Mechanic-Hamilton, Shokufeh Sadaghiani, Banafsheh Shakibajahromi, Sudipto Dolui, Sandhitsu Das, Christopher Brown, William Tackett, Pulkit Khandelwal, Philip Cook, Russell T. Shinohara, Paul Yushkevich, Danielle S. Bassett, David A. Wolk, John A. Detre
We used indirect brain mapping with virtual lesion tractography to test the hypothesis that the extent of white matter tract disconnection due to white matter hyperintensities (WMH) is associated with corresponding tract-specific cognitive performance decrements. To estimate tract disconnection, WMH masks were extracted from FLAIR MRI data of 481 cognitively intact participants in the Alzheimer’s Disease
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Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-02 Xiaomin Tang, Haoyue Zhong, Chenyu Xu, Yuxuan Sun, Yuxiang Lou, Yi Zhao, Yue Liang, Xiaotao Guo, Chunchen Pan, Jiaqiang Sun, Jingwu Sun
KCNMA1 encodes the K+ potassium channel α-subunit that plays a significant role in the auditory system. Our previous studies indicated that KCNMA1 is associated with age-related hearing loss(AHL). However, the detailed mechanism of KCNMA1 involvement in auditory age-related degradation has not been fully clarified. Therefore, we explored the expression of KCNMA1 in the peripheral auditory of 2-month-old
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Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences Neurobiol. Aging (IF 4.2) Pub Date : 2023-12-05 Jasmin M. Kizilirmak, Joram Soch, Anni Richter, Björn H. Schott
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Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-28 Adam H. Dyer, Helene McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, Leane Hoey, Catherine F. Hughes, Mary Ward, JJ Strain, Maurice O’Kane, Fergal Tracey, Anne M. Molloy, Conal Cunningham, Kevin McCarroll
Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific
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Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson’s disease Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-28 Claudio Babiloni, Giuseppe Noce, Federico Tucci, Dharmendra Jakhar, Raffaele Ferri, Simonetta Panerai, Valentina Catania, Andrea Soricelli, Marco Salvatore, Flavio Nobili, Dario Arnaldi, Francesco Famà, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Fabiana Radicati, Peter Fuhr, Ute Gschwandtner, Claudio Del Percio
Here, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson’s disease dementia (PDD) than in patients with Alzheimer’s disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and
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Does functional system segregation mediate the effects of lifestyle on cognition in older adults? Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-25 Petar P. Raykov, Ethan Knights, , Richard N. Henson
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of “cognitive reserve”. Other work has shown that increasing age is associated with reduced segregation of large-scale
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Reliability and generalizability of neural speech tracking in younger and older adults Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-21 Ryan A. Panela, Francesca Copelli, Björn Herrmann
Neural tracking of spoken speech is considered a potential clinical biomarker for speech-processing difficulties, but the reliability of neural speech tracking is unclear. Here, younger and older adults listened to stories in two sessions while electroencephalography was recorded to investigate the reliability and generalizability of neural speech tracking. Speech tracking amplitude was larger for
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Prevalence of cerebral microbleeds in Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease dementia: A systematic review and meta-analysis Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-19 Kai Sin Chin, Sarah Holper, Paula Loveland, Leonid Churilov, Nawaf Yassi, Rosie Watson
Cerebral microbleeds (CMB) are often associated with vascular risk factors and/or cerebral amyloid angiopathy and are frequently identified in people with dementia. The present study therefore aimed to estimate the pooled prevalence and associations of CMB in Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), using meta-analytic methods. Sixty-five MRI
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Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-17 John Woulfe, David G. Munoz, Douglas A. Gray, Hyder A. Jinnah, Alyona Ivanova
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Midlife physical activity engagement is associated with later-life brain health Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-11 Meishan Ai, Timothy P. Morris, Adrián Noriega de la Colina, Nagashree Thovinakere, Jennifer Tremblay-Mercier, Sylvia Villeneuve, Charles H. Hillman, Arthur F. Kramer, Maiya R. Geddes
The relationship between midlife physical activity (PA), and cognition and brain health in later life is poorly understood with conflicting results from previous research. Investigating the contribution of midlife PA to later-life cognition and brain health in high-risk populations will propel the development of health guidance for those most in need. The current study examined the association between
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A genetic and transcriptomic assessment of the KTN1 gene in Parkinson’s disease risk Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-10 Anni Moore, Peter Wild Crea, Mary Makarious, Sara Bandres-Ciga, Cornelis Blauwendraat, , Monica Diez-Fairen
Parkinson’s disease (PD) is a progressive neurological disorder caused by both genetic and environmental factors. An association has been described between KTN1 genetic variants and changes in its expression in the putamen and substantia nigra brain regions and an increased risk for PD. Here, we examine the link between PD susceptibility and KTN1 using individual-level genotyping data and summary statistics
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Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: A longitudinal study Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-08 Jie-Qiong Li, Jing-Hui Song, John Suckling, Yan-Jiang Wang, Chuan-Tao Zuo, Can Zhang, Jing Gao, Yu-Qiang Song, An-Mu Xie, Lan Tan, Jin-Tai Yu
Based on the 'AT(N)' system, individuals with normal amyloid biomarkers but abnormal tauopathy or neurodegeneration biomarkers are classified as non-Alzheimer's disease (AD) pathologic change. This study aimed to assess the long-term clinical and cognitive trajectories of individuals with non-AD pathologic change among older adults without dementia, comparing them to those with normal AD biomarkers
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Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans Neurobiol. Aging (IF 4.2) Pub Date : 2023-11-08 Melissa Lamar, Konstantinos Arfanakis, Arnold Evia, Nazanin Makkinejad, Ana W. Capuano, Namhee Kim, Sue E. Leurgans, Debra A. Fleischman, S. Duke Han, Victoria Poole, Lisa L. Barnes
At autopsy, African American decedents often have mixed Alzheimer’s and cerebrovascular brain pathologies including arteriolosclerosis. We applied a novel in-vivo classifier of ARTerioloSclerosis (ARTS) in 167 older African Americans (∼75y of age) with > 2 biennial 3 T MRI scans and > 3 years of associated cognitive follow-up to determine if ARTS scores (higher score=higher likelihood of arteriolosclerosis)
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DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-31 Claire J. Ciampa, Thomas M. Morin, Alice Murphy, Renaud La Joie, Susan M. Landau, Anne S. Berry
Previous work has associated polymorphisms in the dopamine transporter gene (rs6347 in DAT1/SLC6A3) and brain derived neurotrophic factor gene (Val66Met in BDNF) with atrophy and memory decline. However, it is unclear whether these polymorphisms relate to atrophy and cognition through associations with Alzheimer’s disease pathology. We tested for effects of DAT1 and BDNF polymorphisms on cross-sectional
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Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer’s Disease in individuals of African Ancestry Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-31 Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Mike L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance,
There is a paucity of genetic studies of Alzheimer Disease (AD) in individuals of African Ancestry, despite evidence suggesting increased risk of AD in the African American (AA) population. We performed whole-genome sequencing (WGS) and multipoint linkage analyses in 51 multi-generational AA AD families ascertained through the Research in African American Alzheimer Disease Initiative (REAAADI) and
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Dopamine transporter positron emission tomography in patients with Alzheimer’s disease with Lewy body disease features Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-21 Sungwoo Kang, Seun Jeon, Young-gun Lee, Byoung Seok Ye
In 36 normal controls (NC), 37 patients with Alzheimer’s disease (AD) without parkinsonism (ADP-), 31 AD with parkinsonism (ADP+), and 40 AD with dementia with Lewy bodies (ADDLB), dual-phase dopamine transporter (DAT) positron emission tomography (PET) were performed to evaluate the diagnostic performance of DAT and early-to-delayed uptake ratios (E/Ds) in the anterior caudate (AC), posterior caudate
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Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-20 Nikolai Malykhin, Wojciech Pietrasik, Kim Ngan Hoang, Yushan Huang
In the present study we investigated whether hippocampal subfield (cornu ammonis 1–3, dentate gyrus, and subiculum) and anteroposterior hippocampal subregion (head,body, and tail) volumes can predict episodic memory function using high-field high resolution structural magnetic resonance imaging (MRI). We recruited 126 healthy participants (18–85 years). MRI datasets were collected on a 4.7 T system
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Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-20 Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. Two of 3 patients with AD are biologically female; therefore, the biological underpinnings of this diagnosis disparity may inform interventions slowing the AD progression. To bridge this gap, we conducted analyses of 1078 male and female participants from the Alzheimer’s Disease Neuroimaging
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FRONTOPARIETAL FUNCTION AND UNDERLYING STRUCTURE REFLECT CAPACITY FOR MOTOR SKILL ACQUISITION DURING HEALTHY AGING Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-20 Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christy Jones, Beverley C. Larssen, Lara A. Boyd
While capacity for motor skill acquisition changes with healthy aging, there has been little consideration of how age-related changes in brain function or baseline brain structure support motor skill acquisition. We examined: 1) age-dependent changes in functional reorganization related to frontoparietal regions during motor skill acquisition, and 2) whether capacity for motor skill acquisition relates
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Metformin, age-related cognitive decline, and brain pathology Neurobiol. Aging (IF 4.2) Pub Date : 2023-10-17 Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
The objective of this study was to evaluate the relation of metformin with change in cognition and brain pathology. During a mean of 8 years (SD = 5.5) of annual follow-up visits, 262/3029 participants were using metformin at any time during the study. Using a linear-mixed effect model adjusted for age, sex, and education, metformin users had slower decline on a score of global cognition compared to