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Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Fabien Almairac; Jeremy Deverdun; Jérôme Cochereau; Arthur Coget; Anne-Laure Lemaitre; Sylvie Moritz-Gasser; Hugues Duffau; Guillaume Herbet
Objective In the event of neural injury, the homologous contralateral brain areas may play a compensatory role to avoid or limit the functional loss. However, this dynamic strategy of functional redistribution is not clearly established, especially in the pathophysiological context of diffuse low-grade glioma. Our aim here was to assess the extent to which unilateral tumor infiltration of the insula
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In vivo assessment of neurodegeneration in Spinocerebellar taxia type 7 Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Jacob A. Parker; Shabbir H. Merchant; Sanaz Attaripour-Isfahani; Hyun Joo Cho; Patrick McGurrin; Brian P. Brooks; Albert R. La Spada; Mark Hallett; Laryssa A. Huryn; Silvina G. Horovitz
Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease characterized by progressive cerebellar ataxia and retinal degeneration. Increasing loss of visual function complicates the use of clinical scales to track the progression of motor symptoms, hampering our ability to develop accurate biomarkers of disease progression, and thus test the efficacy of potential treatments. We aimed to identify
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Real-time fMRI Neurofeedback Amygdala Training May Influence Kynurenine Pathway Metabolism in Major Depressive Disorder Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Aki Tsuchiyagaito; Jared L. Smith; Nour El-Sabbagh; Vadim Zotev; Masaya Misaki; Obada Al Zoubi; T. Kent Teague; Martin P. Paulus; Jerzy Bodurka; Jonathan Savitz
Real-time fMRI neurofeedback (rtfMRI-nf) left amygdala (LA) training is a promising intervention for major depressive disorder (MDD). We have previously proposed that rtfMRI-nf LA training may reverse depression-associated regional impairments in neuroplasticity and restore information flow within emotion-regulating neural circuits. Inflammatory cytokines as well as the neuroactive metabolites of an
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Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Barbara A.K. Kreilkamp; Andrea McKavanagh; Batil Alonazi; Lorna Bryant; Kumar Das; Udo C. Wieshmann; Anthony G. Marson; Peter N. Taylor; Simon S. Keller
Despite an expanding literature on brain alterations in patients with longstanding epilepsy, few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE). Understanding brain network impairments at diagnosis is necessary to elucidate whether or not brain abnormalities are principally due to the chronicity of the disorder and to develop prognostic markers of treatment outcome
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Widespread White Matter Aberration is Associated with the Severity of Apathy in amnestic Mild Cognitive Impairment: Tract-Based Spatial Statistics analysis Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Tania M. Setiadi; Sander Martens; Esther M. Opmeer; Jan-Bernard C. Marsman; Shankar Tumati; Fransje E. Reesink; Peter P. De Deyn; André Aleman; Branislava Ćurčić-Blake
Apathy is recognized as a prevalent behavioral symptom of amnestic Mild Cognitive Impairment (aMCI). In aMCI, apathy is associated with an increased risk and increases the risk of progression to Alzheimer’s Disease (AD). Previous DTI study in aMCI showed that apathy has been associated with white matter alterations in the cingulum, middle and inferior longitudinal fasciculus, fornix, and uncinate fasciculus
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Multiparametric in vivo analyses of the brain and spine identify structural and metabolic biomarkers in men with adrenomyeloneuropathy Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Isaac M. Adanyeguh; Xiaofang Lou; Eavan Mc Govern; Marie-Pierre Luton; Magali Barbier; Elise Yazbeck; Romain Valabregue; Dinesh Deelchand; Pierre-Gilles Henry; Fanny Mochel
Objective Progressive myelopathy causes severe handicap in men with adrenomyeloneuropathy (AMN), an X-linked disorder due to ABCD1 pathogenic variants. At present, treatments are symptomatic but disease-modifying therapies are under evaluation. Given the small effect size of clinical scales in AMN, biomarkers with higher effect size are needed. Here we used high-resolution magnetic resonance techniques
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EEG measures of sensorimotor processing and their development are abnormal in children with isolated dystonia and dystonic cerebral palsy Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Verity M McClelland; Petra Fischer; Eleonora Foddai; Sofia Dall'Orso; Etienne Burdet; Peter Brown; Jean-Pierre Lin
Dystonia is a disorder of sensorimotor integration associated with abnormal oscillatory activity within the basal ganglia-thalamo-cortical networks. Event-related changes in spectral EEG activity reflect cortical processing but are sparsely investigated in relation to sensorimotor processing in dystonia. This study investigates modulation of sensorimotor cortex EEG activity in response to a proprioceptive
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Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Yifei He; Miriam Steines; Gebhard Sammer; Arne Nagels; Tilo Kircher; Benjamin Straube
Schizophrenia is characterized by marked communication dysfunctions encompassing potential impairments in the processing of social-abstract and non-social-concrete information, especially in everyday situations where multiple modalities are present in the form of speech and gesture. To date, the neurobiological basis of these deficits remains elusive. In a functional magnetic resonance imaging (fMRI)
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Distinguishing Type II Focal Cortical Dysplasias from Normal Cortex: A Novel Normative Modeling Approach Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-19 Kathryn Snyder; Emily P. Whitehead; William H. Theodore; Kareem A. Zaghloul; Souheil J. Inati; Sara K. Inati
Objective Focal cortical dysplasias (FCDs) are a common cause of apparently non-lesional drug-resistant focal epilepsy. Visual detection of subtle FCDs on MRI is clinically important and often challenging. In this study, we implement a set of 3D local image filters adapted from computer vision applications to characterize the appearance of normal cortex surrounding the gray-white junction. We create
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Reduced functional connectivity of default mode network subsystems in depression: meta-analytic evidence and relationship with trait rumination Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-18 Leonardo Tozzi; Xue Zhang; Megan Chesnut; Bailey Holt-Gosselin; Carolina A. Ramirez; Leanne M. Williams
Resting-state functional connectivity changes in the default mode network (DMN) of patients with major depressive disorder (MDD) have been linked to rumination. The DMN is divided into three subsystems: a midline Core, a dorsal medial prefrontal cortex (DMPFC) subsystem, and a medial temporal lobe (MTL) subsystem. We examined resting-state functional connectivity within and between DMN subsystems in
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Fronto-Parietal Involvement in Chronic Stroke Motor Performance When Corticospinal Tract Integrity is Compromised Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-18 Brenton Hordacre; Martín Lotze; Mark Jenkinson; Alberto Lazari; Christen D. Barras; Lara Boyd; Susan Hillier
Background Preserved integrity of the corticospinal tract (CST) is a marker of good upper-limb behavior and recovery following stroke. However, there is less understanding of neural mechanisms that might help facilitate upper-limb motor recovery in stroke survivors with extensive CST damage. Objective The purpose of this study was to investigate resting state functional connectivity in chronic stroke
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Dynamic functional connectivity as a neural correlate of fatigue in multiple sclerosis Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-04 Floris B. Tijhuis; Tommy A.A. Broeders; Fernando A.N. Santos; Menno M. Schoonheim; Joep Killestein; Cyra E. Leurs; Quinten van Geest; Martijn D. Steenwijk; Jeroen J.G. Geurts; Hanneke E. Hulst; Linda Douw
Background More than 80% of multiple sclerosis (MS) patients experience symptoms of fatigue. MS-related fatigue is only partly explained by structural (lesions and atrophy) and functional (brain activation and conventional static functional connectivity) brain properties. Objectives To investigate the relationship of dynamic functional connectivity (dFC) with fatigue in MS patients and to compare dFC
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Clinical feasibility of longitudinal lateral ventricular volume measurements on T2-FLAIR across MRI scanner changes Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-04 Dejan Jakimovski; Robert Zivadinov; Niels Bergsland; Deepa P. Ramasamy; Jesper Hagemeier; Antonia Valentina Genovese; David Hojnacki; Bianca Weinstock-Guttman; Michael G. Dwyer
Background Greater brain atrophy is associated with disability progression (DP) in patients with multiple sclerosis (PwMS). However, methodological challenges limit its routine clinical use. Objective To determine the feasibility of atrophy measures as markers of DP in PwMS scanned across different MRI field strengths. Methods A total of 980 PwMS were scanned on either 1.5 T or 3.0 T MRI scanners.
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Diffusion kurtosis imaging detects subclinical white matter abnormalities in Phenylketonuria Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-09 Sarah C. Hellewell; Thomas Welton; Kate Eisenhuth; Michel C. Tchan; Stuart M. Grieve
Objective Phenylketonuria (PKU) is an autosomal recessive disorder whereby deficiencies in phenylalanine metabolism cause progressive neurological dysfunction. Managing PKU is challenging, with disease monitoring focussed on short-term phenylalanine control rather than measures of neuronal damage. Conventional imaging lacks sensitivity, however diffusion kurtosis imaging (DKI), a new MRI method may
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Lesion distribution and substrate of white matter damage in Myotonic Dystrophy type 1: comparison with Multiple Sclerosis Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-14 Sara Leddy; Laura Serra; Davide Esposito; Camilla Vizzotto; Giovanni Giulietti; Gabriella Silvestri; Antonio Petrucci; Giovanni Meola; Leonardo Lopiano; Mara Cercignani; Marco Bozzali
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Aberrant Brain Oscillatory Coupling from the Primary Motor Cortex in Children with Autism Spectrum Disorders Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-14 Kyung-min An; Takashi Ikeda; Chiaki Hasegawa; Yuko Yoshimura; Sanae Tanaka; Daisuke N. Saito; Ken Yaoi; Sumie Iwasaki; Tetsu Hirosawa; Mitsuru Kikuchi
Autism spectrum disorder (ASD) often involves dysfunction in general motor control and motor coordination, in addition to core symptoms. However, the neural mechanisms underlying motor dysfunction in ASD are poorly understood. To elucidate this issue, we focused on brain oscillations and their coupling in the primary motor cortex (M1). We recorded magnetoencephalography in 18 children with autism spectrum
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Impact of the reperfusion status for predicting the final stroke infarct using deep learning Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 Noëlie Debs; Tae-Hee Cho; David Rousseau; Yves Berthezène; Marielle Buisson; Omer Eker; Laura Mechtouff; Norbert Nighoghossian; Michel Ovize; Carole Frindel
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Evaluating Transcranial Magnetic Stimulation (TMS) induced electric fields in pediatric stroke Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-13 Kathleen E Mantell; Ellen N Sutter; Sina Shirinpour; Samuel T Nemanich; Daniel H Lench; Bernadette T Gillick; Alexander Opitz
Transcranial magnetic stimulation (TMS) is an increasingly popular tool for stroke rehabilitation. Consequently, researchers have started to explore the use of TMS in pediatric stroke. However, the application of TMS in a developing brain with pathologies comes with a unique set of challenges. The effect of TMS-induced electric fields has not been explored in children with stroke lesions. Here, we
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Electrophysiological modulation of sensory and attentional processes during mind wandering in attention-deficit/hyperactivity disorder Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-30 Natali Bozhilova; Jonna Kuntsi; Katya Rubia; Giorgia Michelini; Philip Asherson
We recently reported increased mind wandering (MW) frequency in adults with attention-deficit/hyperactivity disorder (ADHD) relative to controls during high demands on sustained attention, reflecting deficient context regulation of MW. Studies on community samples previously linked context regulation of MW with attenuation in brain sensory processes, reflecting perceptual decoupling, and attentional
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Volitional Modification of Brain Activity in Adolescents with Autism Spectrum Disorder: A Bayesian Analysis of Slow Cortical Potential Neurofeedback Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-09 L. Konicar; S. Radev; K. Prillinger; M. Klöbl; R. Diehm; N. Birbaumer; R. Lanzenberger; P.L. Plener; L. Poustka
Autism Spectrum Disorders are characterized by a persisting triad of impairments of social interaction, language as well as inflexible, stereotyped and ritualistic behaviors. Increasingly, scientific evidence suggests a neurobiological basis of these emotional, social and cognitive deficits in individuals with Autism Spectrum Disorders. The aim of this randomized controlled brain self-regulation intervention
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Disease-related cortical thinning in presymptomatic granulin mutation carriers Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-29 Sergi Borrego-Écija; Roser Sala-Llonch; John van Swieten; Barbara Borroni; Fermín Moreno; Mario Masellis; Carmela Tartaglia; Caroline Graff; Daniela Galimberti; Robert Laforce; James B Rowe; Elizabeth Finger; Rik Vandenberghe; Fabrizio Tagliavini; Alexandre de Mendonça; Isabel Santana; Matthis Synofzik; Simon Ducharme; Sarah Anderl-Straub
Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Genetic Frontotemporal dementia initiative (GENFI), with MRI structural images. We analyzed
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Cerebral amyloid angiopathy is associated with decreased functional brain connectivity Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-24 Nadieh Drenth; Jeroen van der Grond; Serge A.R.B. Rombouts; Mark A. van Buchem; Gisela M. Terwindt; Marieke J.H. Wermer; Jasmeer P. Chhatwal; M. Edip Gurol; Steven M. Greenberg; Sanneke van Rooden
Cerebral amyloid angiopathy (CAA) is a major cause of intracerebral hemorrhage and neurological decline in the elderly. CAA results in focal brain lesions, but the influence on global brain functioning needs further investigation. Here we study functional brain connectivity in patients with Dutch type hereditary CAA using resting state functional MRI. Twenty-four DNA-proven Dutch CAA mutation carriers
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FLAIR-only joint volumetric analysis of brain lesions and atrophy in clinically isolated syndrome (CIS) suggestive of multiple sclerosis Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 O. Goodkin; F. Prados; S.B. Vos; H. Pemberton; S. Collorone; M.H.J. Hagens; M.J. Cardoso; T.A. Yousry; J.S. Thornton; C.H. Sudre; F. Barkhof
Background MRI assessment in multiple sclerosis (MS) focuses on the presence of typical white matter (WM) lesions. Neurodegeneration characterised by brain atrophy is recognised in the research field as an important prognostic factor. It is not routinely reported clinically, in part due to difficulty in achieving reproducible measurements. Automated MRI quantification of WM lesions and brain volume
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The sequence of structural, functional and cognitive changes in multiple sclerosis Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-24 Iris Dekker; Menno M. Schoonheim; Vikram Venkatraghavan; Anand J.C. Eijlers; Iman Brouwer; Esther E. Bron; Stefan Klein; Mike P. Wattjes; Alle Meije Wink; Jeroen J.G. Geurts; Bernard M.J. Uitdehaag; Neil P. Oxtoby; Daniel C. Alexander; Hugo Vrenken; Joep Killestein; Frederik Barkhof; Viktor Wottschel
Background As disease progression remains poorly understood in multiple sclerosis (MS), we aim to investigate the sequence in which different disease milestones occur using a novel data-driven approach. Methods We analysed a cohort of 295 relapse-onset MS patients and 96 healthy controls, and considered 28 features, capturing information on T2-lesion load, regional brain and spinal cord volumes, resting-state
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A voxel-wise assessment of growth differences in infants developing autism spectrum disorder Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-29 A. Cárdenas-de-la-Parra; J.D. Lewis; V.S. Fonov; K.N. Botteron; R.C. McKinstry; G. Gerig; J.R. Pruett; S.R. Dager; J.T. Elison; M.A. Styner; A.C. Evans; J. Piven; D.L Collins
Autism Spectrum Disorder (ASD) is a phenotypically and etiologically heterogeneous developmental disorder typically diagnosed around 4 years of age. The development of biomarkers to help in earlier, presymptomatic diagnosis could facilitate earlier identification and therefore earlier intervention and may lead to better outcomes, as well as providing information to help better understand the underlying
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Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Natália Almeida-Antunes; Alberto Crego; Carina Carbia; Sónia S. Sousa; Rui Rodrigues; Adriana Sampaio; Eduardo López-Caneda
Research on neurophysiological impairments associated with binge drinking (BD), an excessive but episodic alcohol use pattern, has significantly increased over the last decade. This work is the first to systematically review –following PRISMA guidelines- the empirical evidence regarding the effects of BD on neural activity –assessed by electroencephalography- of adolescents and young adults. A systematic
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Lack of Association Between Acute Stroke, Post-Stroke Dementia, Race, and B-amyloid Status Neuroimage Clin. (IF 4.35) Pub Date : 2021-01-05 Lauren N. Koenig; Lena M. McCue; Elizabeth Grant; Parinaz Massoumzadeh; Catherine M. Roe; Chengjie Xiong; Krista L. Moulder; Liang Wang; Allyson R. Zazulia; Peggy Kelly; Aylin Dincer; Aiad Zaza; Joshua S. Shimony; Tammie L.S. Benzinger; John C. Morris
Introduction Stroke and Alzheimer disease share risk factors and often co-occur, and both have been reported to have a higher prevalence in African Americans as compared to non-Hispanic whites. However, their interaction has not been established. The objective of this study was to determine if preclinical Alzheimer disease is a risk factor for stroke and post-stroke dementia and whether racial differences
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Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 Jessica Burggraaff; Yao Liu; Juan C. Prieto; Jorge Simoes; Alexandra de Sitter; Serena Ruggieri; Iman Brouwer; Birgit I. Lissenberg-Witte; Mara A. Rocca; Paola Valsasina; Stefan Ropele; Claudio Gasperini; Antonio Gallo; Deborah Pareto; Jaume Sastre-Garriga; Christian Enzinger; Massimo Filippi; Nicola De Stefano; Charles R.G. Guttmann
Background and rationale Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain
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Towards a tractography-based risk stratification model for language area associated gliomas Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 Mehmet Salih Tuncer; Luca Francesco Salvati; Ulrike Grittner; Juliane Hardt; Ralph Schilling; Ina Bährend; Luca Leandro Silva; Lucius S. Fekonja; Katharina Faust; Peter Vajkoczy; Tizian Rosenstock; Thomas Picht
Objectives Injury to major white matter pathways during language-area associated glioma surgery often leads to permanent loss of neurological function. The aim was to establish standardized tractography of language pathways as a predictor of language outcome in clinical neurosurgery. Methods We prospectively analyzed 50 surgical cases of patients with left perisylvian, diffuse gliomas. Standardized
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Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-29 Jonathan M. DuBois; Sulantha Mathotaarachchi; Olivier G. Rousset; Viviane Sziklas; Jorge Sepulcre; Marie-Christine Guiot; Jeffery A. Hall; Gassan Massarweh; Jean-Paul Soucy; Pedro Rosa-Neto; Eliane Kobayashi
To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP688 PET binding potentials (BPND), which allows for quantification of mGluR5 availability. Undirected graphs were constructed for the entire cortex in 17 FCD patients and 33 healthy controls using inter-regional
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Assessing the state of consciousness for individual patients using complex, statistical stimuli Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 U. Górska; A. Rupp; T. Celikel; B. Englitz
Patients with prolonged disorders of consciousness (PDOC) are often unable to communicate their state of consciousness. Determining the latter is essential for the patient's care and prospects of recovery. Auditory stimulation in combination with neural recordings is a promising technique towards an objective assessment of conscious awareness. Here, we investigated the potential of complex, acoustic
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Synthetic MRI demonstrates prolonged regional relaxation times in the brain of preterm born neonates with severe postnatal morbidity Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-24 Tim Vanderhasselt; Roya Zolfaghari; Maarten Naeyaert; Jeroen Dudink; Nico Buls; Gert-Jan Allemeersch; Hubert Raeymakers; Filip Cools; Johan de Mey
Background To identify preterm infants at risk for neurodevelopment impairment that might benefit from early neurorehabilitation, early prognostic biomarkers of future outcomes are needed. Objective To determine whether synthetic MRI is sensitive to age-related changes in regional tissue relaxation times in the brain of preterm born neonates when scanned at term equivalent age (TEA, 37–42 weeks), and
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Neural mechanisms of acute stress and trait anxiety in adolescents Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 Rachel Corr; Andrea Pelletier-Baldelli; Sarah Glier; Joshua Bizzell; Alana Campbell; Aysenil Belger
Adolescence is a critical period of heightened stress sensitivity and elevated vulnerability for developing mental illness, suggesting a possible association between stress exposure and the etiology of psychiatric disorders. In adults, aberrant neurobiological responses to acute stress relate to anxiety symptoms, yet less is known about the neural stress response in adolescents and how it relates to
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Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-25 Judith Machts; Marius Keute; Joern Kaufmann; Stefanie Schreiber; Elisabeth Kasper; Susanne Petri; Johannes Prudlo; Stefan Vielhaber; Mircea Ariel Schoenfeld
Memory impairment in motor neuron disease (MND) is still an underrecognized feature and has traditionally been attributed to executive dysfunction. Here, we investigate the rate of memory impairment in a longitudinal cohort of MND patients, its relationship to other cognitive functions and the underlying neuroanatomical correlates. 142 patients with MND and 99 healthy controls (HC) underwent comprehensive
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Subacute functional connectivity correlates with cognitive recovery six months after stroke Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Jéssica Elias Vicentini; Marina Weiler; Raphael Fernandes Casseb; Sara Regina Almeida; Lenise Valler; Brunno Machado de Campos; Li Min Li
Background and purpose Cognitive impairment is a common consequence of stroke, and the rewiring of the surviving brain circuits might contribute to cognitive recovery. Studies investigating how the functional connectivity of networks change across time and whether their remapping relates to cognitive recovery in stroke patients are scarce. We aimed to investigate whether resting-state functional connectivity
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Stroke core revealed by tissue scattering using spatial frequency domain imaging Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Smrithi Sunil; Sefik Evren Erdener; Xiaojun Cheng; Sreekanth Kura; Jianbo Tang; John Jiang; Kavon Karrobi; Kıvılcım Kılıç; Darren Roblyer; David A. Boas
Ischemic stroke leads to a reduction or complete loss of blood supply causing injury to brain tissue, which ultimately leads to behavioral impairment. Optical techniques are widely used to study the structural and functional changes that result as a consequence of ischemic stroke both in the acute and chronic phases of stroke recovery. It is currently a challenge to accurately estimate the spatial
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Arterial spin labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Arnaud Coez; Ludovic Fillon; Ana Saitovitch; Caroline Rutten; Sandrine Marlin; Jennifer Boisgontier; Alice Vinçon-Leite; Hervé Lemaitre; David Grévent; Charles-Joris Roux; Volodia Dangouloff-Ros; Raphaël levy; Eric Bizaguet; Isabelle Rouillon; Eréa Noël Garabédian; Françoise Denoyelle; Monica Zilbovicius; Natalie Loundon; Nathalie Boddaert
Age at implantation is considered to be a major factor, influencing outcomes after pediatric cochlear implantation. In the absence of acoustic input, it has been proposed that cross-modal reorganization can be detrimental for adaptation to the new electrical input provided by a cochlear implant. Here, through a retrospective study, we aimed to investigate differences in cerebral blood flow (CBF) at
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Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Leonie Beyer; Johanna Meyer-Wilmes; Sonja Schönecker; Jonas Schnabel; Julia Sauerbeck; Maximilian Scheifele; Catharina Prix; Marcus Unterrainer; Cihan Catak; Oliver Pogarell; Carla Palleis; Robert Perneczky; Adrian Danek; Katharina Buerger; Peter Bartenstein; Johannes Levin; Axel Rominger; Michael Ewers; Matthias Brendel
Background and objective Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of education guards against the impact of brain alterations also in frontotemporal dementia (FTD) has not been shown in a large patient collective
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GAMER MRI: Gated-attention mechanism ranking of multi-contrast MRI in brain pathology Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Po-Jui Lu; Youngjin Yoo; Reza Rahmanzadeh; Riccardo Galbusera; Matthias Weigel; Pascal Ceccaldi; Thanh D. Nguyen; Pascal Spincemaille; Yi Wang; Alessandro Daducci; Francesco La Rosa; Meritxell Bach Cuadra; Robin Sandkühler; Kambiz Nael; Amish Doshi; Zahi A. Fayad; Jens Kuhle; Ludwig Kappos; Cristina Granziera
Introduction During the last decade, a multitude of novel quantitative and semiquantitative MRI techniques have provided new information about the pathophysiology of neurological diseases. Yet, selection of the most relevant contrasts for a given pathology remains challenging. In this work, we developed and validated a method, Gated-Attention MEchanism Ranking of multi-contrast MRI in brain pathology
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Support vector machine based aphasia classification of transcranial magnetic stimulation language mapping in brain tumor patients Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-24 Ziqian Wang; Felix Dreyer; Friedemann Pulvermüller; Effrosyni Ntemou; Peter Vajkoczy; Lucius S. Fekonja; Thomas Picht
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Disentangling the effects of age and mild traumatic brain injury on brain network connectivity: A resting state fMRI study Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 M. Bittencourt-Villalpando; H.J. van der Horn; N.M. Maurits; J. van der Naalt
Introduction Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated. Methods Fifty-four mTBI patients (median age: 35 years, range 19–64 years, 67% male) and twenty age- and sex-matched healthy controls were studied
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Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer’s disease spectrum Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-22 Chimezie O. Amaefule; Martin Dyrba; Steffen Wolfsgruber; Alexandra Polcher; Anja Schneider; Klaus Fliessbach; Annika Spottke; Dix Meiberth; Lukas Preis; Oliver Peters; Enise I. Incesoy; Eike J. Spruth; Josef Priller; Slawek Altenstein; Claudia Bartels; Jens Wiltfang; Daniel Janowitz; Katharina Bürger; Stefan J. Teipel
Background Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer’s disease (AD) in structural and functional imaging (fMRI) studies. Most previous studies have used single test scores of cognitive performance among monocentric cohorts. However, cognitive domain composite scores could be more reliable than single test scores
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Neural correlates of resilience to the effects of hippocampal atrophy on memory Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-07 Sylvie Belleville; Samira Mellah; Simon Cloutier; Thien Thanh Dang-Vu; Simon Duchesne; Samantha Maltezos; Natalie Phillips; Carol Hudon
Introduction Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain imaging to identify which cognitive reserve mechanisms protect against the detrimental effect of hippocampal atrophy on associative memory. Methods The study included 108 older adults from the Quebec Consortium
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A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA) Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-08 Michelle K. Lupton; Gail A. Robinson; Robert J. Adam; Stephen Rose; Gerard J. Byrne; Olivier Salvado; Nancy A. Pachana; Osvaldo P. Almeida; Kerrie McAloney; Scott D Gordon; Parnesh Raniga; Amir Fazlollahi; Ying Xia; Amelia Ceslis; Saurabh Sonkusare; Qing Zhang; Mahnoosh Kholghi; Mohan Karunanithi; Michael Breakspear
This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer’s disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify
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Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-03 Lauren E. Gascoyne; Matthew J. Brookes; Mohanbabu Rathnaiah; Mohammad Zia Ul Haq Katshu; Loes Koelewijn; Gemma Williams; Jyothika Kumar; James T.R. Walters; Zelekha A. Seedat; Lena Palaniyappan; J.F. William Deakin; Krish D. Singh; Peter F. Liddle; Peter G. Morris
Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrease (MRBD) and the post-movement beta rebound (PMBR) are well-characterised effects in magnetoencephalography (MEG), with the latter having been shown to
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Predicting outcomes of cross-sex hormone therapy in transgender individuals with gender incongruence based on pre-therapy resting-state brain connectivity Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-02 Teena D Moody; Jamie D. Feusner; Nicco Reggente; Jonathan Vanhoecke; Mats Holmberg; Amirhossein Manzouri; Behzad Sorouri Khorashad; Ivanka Savic
Individuals with gender incongruence (GI) experience serious distress due to incongruence between their gender identity and birth-assigned sex. Sociological, cultural, interpersonal, and biological factors are likely contributory, and for some individuals medical treatment such as cross-sex hormone therapy and gender-affirming surgery can be helpful. Cross-sex hormone therapy can be effective for reducing
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Temporal-thalamic and cingulo-opercular connectivity in people with schizophrenia Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-11 Adam J. Culbreth; Qiong Wu; Shuo Chen; Bhim M. Adhikari; L. Elliot Hong; James M. Gold; James A. Waltz
A growing body of research has suggested that people with schizophrenia (SZ) exhibit altered patterns of functional and anatomical brain connectivity. For example, many previous resting state functional connectivity (rsFC) studies have shown that, compared to healthy controls (HC), people with SZ demonstrate hyperconnectivity between subregions of the thalamus and sensory cortices, as well as hypoconnectivity
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Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-05 Sagar Buch; Karthikeyan Subramanian; Pavan K. Jella; Yongsheng Chen; Zhen Wu; Kamran Shah; Evanthia Bernitsas; Yulin Ge; E. Mark Haacke
Background and Purpose Multiple Sclerosis (MS) is a progressive, inflammatory, neuro-degenerative disease of the central nervous system (CNS) characterized by a wide range of histopathological features including vascular abnormalities. In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce an increase in susceptibility for both arteries
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Multi-modal biomarkers of low back pain: A machine learning approach Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-08 Bidhan Lamichhane; Dinal Jayasekera; Rachel Jakes; Matthew F. Glasser; Justin Zhang; Chunhui Yang; Derayvia Grimes; Tyler L. Frank; Wilson Z. Ray; Eric C. Leuthardt; Ammar H. Hawasli
Chronic low back pain (LBP) is a very common health problem worldwide and a major cause of disability. Yet, the lack of quantifiable metrics on which to base clinical decisions leads to imprecise treatments, unnecessary surgery and reduced patient outcomes. Although, the focus of LBP has largely focused on the spine, the literature demonstrates a robust reorganization of the human brain in the setting
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The cingulum in very preterm infants relates to language and social-emotional impairment at 2 years of term-equivalent age Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-08 Hyun Ju Lee; Hyeokjin Kwon; Johanna Inhyang Kim; Joo Young Lee; Ji Young Lee; SungKyu Bang; Jong-Min Lee
Background Relative to full-term infants, very preterm infants exhibit disrupted white matter (WM) maturation and problems related to development, including motor, cognitive, social-emotional, and receptive and expressive language processing. Objective The present study aimed to determine whether regional abnormalities in the WM microstructure of very preterm infants, as defined relative to those of
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Neural processing of facial identity and expression in adults with and without autism: A multi-method approach Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-03 Michelle H.A. Hendriks; Claudia Dillen; Sofie Vettori; Laura Vercammen; Nicky Daniels; Jean Steyaert; Hans Op de Beeck; Bart Boets
The ability to recognize faces and facial expressions is a common human talent. It has, however, been suggested to be impaired in individuals with autism spectrum disorder (ASD). The goal of this study was to compare the processing of facial identity and emotion between individuals with ASD and neurotypicals (NTs). Behavioural and functional magnetic resonance imaging (fMRI) data from 46 young adults
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Atlas-independent, N-of-1 tissue activation modeling to map optimal regions of subthalamic deep brain stimulation for Parkinson disease Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-03 Karlo A. Malaga; Joseph T. Costello; Kelvin L. Chou; Parag G. Patil
Background Motor outcomes after subthalamic deep brain stimulation (STN DBS) for Parkinson disease (PD) vary considerably among patients and strongly depend on stimulation location. The objective of this retrospective study was to map the regions of optimal STN DBS for PD using an atlas-independent, fully individualized (N-of-1) tissue activation modeling approach and to assess the relationship between
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Eye gaze patterns and functional brain responses during emotional face processing in adolescents with conduct disorder Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-03 Willeke Martine Menks; Lynn Valérie Fehlbaum; Réka Borbás; Philipp Sterzer; Christina Stadler; Nora Maria Raschle
Background Conduct disorder (CD) is characterized by severe aggressive and antisocial behavior. Initial evidence suggests neural deficits and aberrant eye gaze pattern during emotion processing in CD; both concepts, however, have not yet been studied simultaneously. The present study assessed the functional brain correlates of emotional face processing with and without consideration of concurrent eye
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Reduced anxiety and changes in amygdala network properties in adolescents with training for awareness, resilience, and action (TARA) Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-03 Olga Tymofiyeva; Eva Henje; Justin P. Yuan; Chiung-Yu Huang; Colm G. Connolly; Tiffany C. Ho; Sarina Bhandari; Kendall C. Parks; Benjamin S. Sipes; Tony T. Yang; Duan Xu
Mindfulness-based approaches show promise to improve emotional health in youth and may help treat and prevent adolescent depression and anxiety. However, there is a fundamental gap in understanding the neural reorganization that takes place as a result of such interventions. The Training for Awareness, Resilience, and Action (TARA) program, initially developed for depressed adolescents, uses a framework
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Brain anatomical covariation patterns linked to binge drinking and age at first full drink Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-08 Yihong Zhao; R. Todd Constable; Denise Hien; Tammy Chung; Marc N. Potenza
Binge drinking and age at first full drink (AFD) of alcohol prior to 21 years (AFD < 21) have been linked to neuroanatomical differences in cortical and subcortical grey matter (GM) volume, cortical thickness, and surface area. Despite the importance of understanding network-level relationships, structural covariation patterns among these morphological measures have yet to be examined in relation to
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Classification of evoked responses to inverted faces reveals both spatial and temporal cortical response abnormalities in Autism spectrum disorder Neuroimage Clin. (IF 4.35) Pub Date : 2020-11-30 Adonay S. Nunes; Fahimeh Mamashli; Nataliia Kozhemiako; Sheraz Khan; Nicole M. McGuiggan; Ainsley Losh; Robert M. Joseph; Jyrki Ahveninen; Sam M. Doesburg; Matti S. Hämäläinen; Tal Kenet
The neurophysiology of face processing has been studied extensively in the context of social impairments associated with autism spectrum disorder (ASD), but the existing studies have concentrated mainly on univariate analyses of responses to upright faces, and, less frequently, inverted faces. The small number of existing studies on neurophysiological responses to inverted face in ASD have used univariate
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Multimodal MRI staging for tracking progression and clinical-imaging correlation in sporadic Creutzfeldt-Jakob disease Neuroimage Clin. (IF 4.35) Pub Date : 2020-12-11 Simone Sacco; Matteo Paoletti; Adam M. Staffaroni; Huicong Kang; Julio Rojas; Gabe Marx; Sheng-yang Goh; Maria Luisa Mandelli; Isabel E. Allen; Joel H. Kramer; Stefano Bastianello; Roland G. Henry; Howie.J. Rosen; Eduardo Caverzasi; Michael D. Geschwind
Diffusion imaging is very useful for the diagnosis of sporadic Creutzfeldt-Jakob disease, but it has limitations in tracking disease progression as mean diffusivity changes non-linearly across the disease course. We previously showed that mean diffusivity changes across the disease course follow a quasi J-shaped curve, characterized by decreased values in earlier phases and increasing values later