-
Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-16 Fabrice Wendling, Elif Koksal-Ersoz, Mariam Al-Harrach, Maxime Yochum, Isabelle Merlet, Giulio Ruffini, Fabrice Bartolomei, Pascal Benquet
The aim is to gain insight into the pathophysiological mechanisms underlying interictal epileptiform discharges observed in electroencephalographic (EEG) and stereo-EEG (SEEG, depth electrodes) recordings performed during pre-surgical evaluation of patients with drug-resistant epilepsy. We developed novel neuro-inspired computational models of the human cerebral cortex at three different levels of
-
Prevalence of Clinical Electroencephalography Findings in Stroke Patients with Delirium Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-16 Noa B. Mintz, Nicholas Andrews, Kelly Pan, Eric Bessette, Wael F. Asaad, Mohamed Sherif, Clio Rubinos, Ali Mahta, Timothy D. Girard, Michael E. Reznik
Delirium is an acute cognitive disorder associated with multiple electroencephalographic (EEG) abnormalities in non-neurological patients, though specific EEG characteristics in patients with stroke remain unclear. We aimed to compare the prevalence of EEG abnormalities in stroke patients during delirium episodes with periods that did not correspond to delirium. We retrospectively analyzed clinical
-
Clinical Outcome Prediction with an automated EEG trend, Brain State of the Newborn, after perinatal asphyxia Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-15 Saeed Montazeri Moghadam, Päivi Nevalainen, Marjo Metsäranta, Nathan J. Stevenson, Sampsa Vanhatalo
To evaluate the utility of a fully automated deep learning -based quantitative measure of EEG background, Brain State of the Newborn (BSN), for early prediction of clinical outcome at four years of age. The EEG monitoring data from eighty consecutive newborns was analyzed using the automatically computed BSN trend. BSN levels during the first days of life (a of total 5427 hours) were compared to four
-
Mapping cortico-cortical evoked potentials to glioma grading and language outcome Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-15 Davide Giampiccolo, Riki Matsumoto
-
EEG alpha reactivity on eyes opening discriminates patients with schizophrenia and schizoaffective disorder Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-13 Zhanna Garakh, Ekaterina Larionova, Alexander Shmukler, Jiří Horáček, Yuliya Zaytseva
Alpha activity in the electroencephalogram (EEG) is typically dominant during rest with closed eyes but suppressed by visual stimulation. Previous research has shown that alpha-blockade is less pronounced in schizophrenia patients compared to healthy individuals, but no studies have examined it in schizoaffective disorder. A resting state EEG was used for the analysis of the alpha-reactivity between
-
The effect of propofol on effective brain networks Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-08 D. van Blooijs, S. Blok, G.J.M. Huiskamp, P. van Eijsden, H.G.E. Meijer, F.S.S. Leijten
We compared the effective networks derived from Single Pulse Electrical Stimulation (SPES) in intracranial electrocorticography (ECoG) of awake epilepsy patients and while under general propofol-anesthesia to investigate the effect of propofol on these brain networks. We included nine patients who underwent ECoG for epilepsy surgery evaluation. We performed SPES when the patient was awake (SPES-clinical)
-
The complementary use of muscle ultrasound and MRI in FSHD: Early versus later disease stage follow-up Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-07 Sanne C.C. Vincenten, Nicol C. Voermans, Donnie Cameron, Baziel G. M. van Engelen, Nens van Alfen, Karlien Mul
Muscle MRI and ultrasound provide complementary techniques for characterizing muscle changes and tracking disease progression in facioscapulohumeral muscular dystrophy (FSHD). In this cohort study, we provide longitudinal data that compares both imaging modalities head-to-head. FSHD patients were assessed at baseline and after five years. Standardized muscle MRI and ultrasound images of five leg muscles
-
Unique combinations of ultrasound and electrophysiological findings distinguish Friedreich’s ataxia from other inherited ataxias Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-07 Luciana Pelosi, Eoin Mulroy, Ruth Leadbetter, Miriam Rodrigues, Richard Roxburgh
-
Reply to “Ultrasonographic Follow-up in Bell’s Palsy: Part (of the Facial Nerve) to Look at?” Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-07 Giuseppe Di Pietro, Pietro Falco, Andrea Truini
-
Resting-state EEG rhythms are abnormal in post COVID-19 patients with brain fog without cognitive and affective disorders Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-06 Claudio Babiloni, Elio Gentilini Cacciola, Federico Tucci, Paolo Vassalini, Agnese Chilovi, Dharmendra Jakhar, Andreea Maria Musat, Marco Salvatore, Andrea Soricelli, Fabrizio Stocchi, Laura Vacca, Raffaele Ferri, Valentina Catania, Claudio Mastroianni, Gabriella D'Ettorre, Giuseppe Noce
Several persons experiencing post-covid-19 (post-COVID) with “brain fog” (e.g., fatigue, cognitive and psychiatric disorders, etc.) show abnormal resting-state electroencephalographic (rsEEG) rhythms reflecting a vigilance dysfunction. Here, we tested the hypothesis that in those post-COVID persons, abnormal rsEEG rhythms may occur even when cognitive and psychiatric disorders are absent. The experiments
-
Relative contribution of sensory and motor deficits on grip force control in patients with chronic stroke Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-06 Ryo Akaguchi, Yusaku Takamura, Hiroyuki Okuno, Shu Morioka, Noritaka Kawashima
This study aimed to characterize grasping behavior in static (weight-dependent modulation and stability of control) and dynamic (predictive control) aspects specifically focusing on the relative contribution of sensory and motor deficits to grip force control in patients with chronic stroke. Twenty-four chronic stroke patients performed three manipulative tasks: five trials of 5-s grasp-lift-holding
-
Assessing ulnar neuropathy at the elbow using magnetoneurography Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-06 Yuta Tanaka, Toru Sasaki, Shigenori Kawabata, Jun Hashimoto, Hisato Higashikawa, Yuko Hoshino, Kensuke Sekihara, Yoshiaki Adachi, Koji Fujita, Akimoto Nimura, Taishi Watanabe, Yuki Miyano, Saeri Kaminaka, Yusuke Yamamoto, Toshitaka Yoshii
To measure neuromagnetic fields of ulnar neuropathy patients at the elbow after electrical stimulation and evaluate ulnar nerve function at the elbow with high spatial resolution. A superconducting quantum interference device magnetometer system recorded neuromagnetic fields of the ulnar nerve at the elbow after electrical stimulation at the wrist in 16 limbs of 16 healthy volunteers and 21 limbs of
-
Cortico-cortical evoked potentials of language tracts in minimally invasive glioma surgery guided by Penfield stimulation Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-05 Kathleen Seidel, Jonathan Wermelinger, Pablo Alvarez-Abut, Vedran Deletis, Andreas Raabe, David Zhang, Philippe Schucht
We investigated the feasibility of recording cortico-cortical evoked potentials (CCEPs) in patients with low- and high-grade glioma. We compared CCEPs during awake and asleep surgery, as well as those stimulated from the functional Broca area and recorded from the functional Wernicke area (BtW), and vice versa (WtB). We also analyzed CCEP properties according to tumor location, histopathology, and
-
Infant mismatch responses to speech-sound changes predict language development in preschoolers at risk for dyslexia Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-05 Sergio Navarrete-Arroyo, Paula Virtala, Peixin Nie, Linda Kailaheimo-Lönnqvist, Satu Salonen, Teija Kujala
We investigated how infant mismatch responses (MMRs), which have the potential for providing information on auditory discrimination abilities, could predict subsequent development of pre-reading skills and the risk for familial dyslexia. We recorded MMRs to vowel, duration, and frequency deviants in pseudo-words at birth and 28 months in a sample over-represented by infants with dyslexia risk. We examined
-
The feasibility and technical aspects of trigemino-cervical reflex elicitation in humans under general anesthesia Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-05 Denise Lima Medeiros de Melo, Enio Alberto Comerlato, Denise Spinola Pinheiro, Gilberto Mastrocola Manzano
To analyze the feasibility, neurophysiological aspects, stimulation patterns, and topographic distribution of trigemino-cervical reflex (TCR) components in humans under general anesthesia. This prospective observational study enrolled 20 participants who underwent posterior fossa surgery, surgical proceduresin thecraniovertebral junction,or spinal cord surgery. TCR responses were simultaneously recorded
-
Ultrasonographic follow-up in Bell’s Palsy: Part (of the facial Nerve) to look at? Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-04 Ahmad J. Abdulsalam, Mahmud Fazıl Aksakal, Murat Kara, Bayram Kaymak, Levent Özçakar
-
Disruption of alpha oscillation propagation in patients with schizophrenia Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-03-04 Duho Sihn, Sung-Phil Kim
Propagation of electroencephalogram (EEG) oscillations, often referred to as traveling waves, reflects the role of brain oscillations in neural information transmission. This propagation can be distorted by brain disorders such as schizophrenia that features disconnection of neural information transmission (i.e., disconnection syndrome). However, this possibility of the disruption of EEG oscillation
-
TDCS for parkinson‘s disease disease-related pain: A randomized trial Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-28 Yeray González-Zamorano, Francisco José Sánchez-Cuesta, Marcos Moreno-Verdú, Aida Arroyo-Ferrer, Josué Fernández-Carnero, K. Ray Chaudhuri, Anna Fieldwalker, Juan Pablo Romero
[Display omitted]
-
Microstate dynamics and spectral components as markers of persistent and remittent attention-deficit/hyperactivity disorder Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-28 GuiSen Wu, XiXi Zhao, XiangSheng Luo, Hui Li, YanBo Chen, Chen Dang, Li Sun
We leveraged microstate characteristics and power features to examine temporal and spectral deviations underlying persistent and remittent attention-deficit/hyperactivity disorder (ADHD). 50 young adults with childhood ADHD (28 persisters, 22 remitters) and 28 demographically similar healthy controls (HC) were compared on microstates features and frequency principal components (f-PCs) of eye-closed
-
Corticospinal inhibition investigated in relation to upper extremity motor function in cervical spinal cord injury Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-28 Tarun Arora, Jia Liu, Akhil Mohan, Xin Li, Kyle O'laughlin, Teale Bennett, Gregory Nemunaitis, Francois Bethoux, Svetlana Pundik, Gail Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, M. Kristi Henzel, Xiaofeng Wang, Kelsey Baker, Nabila Brihmat, Mehmed Bayram, Ela B. Plow
Corticospinal inhibitory mechanisms are relevant to functional recovery but remain poorly understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent period (CSP), a measure of corticospinal inhibition evaluated using transcranial magnetic stimulation (TMS), is inconsistent in literature. We envisioned that investigating CSP across muscles with varying degrees of
-
Intraoperative neuromonitoring as real-time diagnostic for cerebral ischemia in endovascular treatment of ruptured brain aneurysms Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-27 Abdullah M. Al-Qudah, Parthasarathy D. Thirumala, Katherine M. Anetakis, Donald J. Crammond, Saleh A. Algarni, Mohammad AlMajali, Varun Shandal, Bradley A. Gross, Michael Lang, Nirav R. Bhatt, Alhamza R. Al-Bayati, Raul G. Nogueira, Jeffrey R. Balzer
To evaluate the diagnostic accuracy of intraoperative neurophysiological monitoring (IONM) during endovascular treatment (EVT) of ruptured intracranial aneurysms (rIA). IONM and clinical data from 323 patients who underwent EVT for rIA from 2014-2019 were retrospectively reviewed. Significant IONM changes and outcomes were evaluated based on visual review of data and clinical documentation. Of the
-
Distributed source modeling of stereoencephalographic measurements of ictal activity Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-23 Hsin-Ju Lee, Lin-Yao Chien, Hsiang-Yu Yu, Cheng-Chia Lee, Chien-Chen Chou, Wen-Jui Kuo, Fa-Hsuan Lin
Stereoelectroencephalography (SEEG) can define the epileptogenic zone (EZ). However, SEEG is susceptible to the sampling bias, where no SEEG recording is taken within a circumscribed EZ. Nine patients with medically refractory epilepsy underwent SEEG recording, and brain resection got positive outcomes. Ictal neuronal currents were estimated by distributed source modeling using the SEEG data and individual’s
-
Measurable transitions during seizures in intracranial EEG: A stereoelectroencephalography and SPECT study Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-23 Balu Krishnan, Simon Tousseyn, Kenneth Taylor, Guiyun Wu, Demitre Serletis, Imad Najm, Juan Bulacio, Andreas V. Alexopoulos
Ictal Single Photon Emission Computed Tomography (SPECT) and stereo-electroencephalography (SEEG) are diagnostic techniques used for the management of patients with drug-resistant focal epilepsies. While hyperperfusion patterns in ictal SPECT studies reveal seizure onset and propagation pathways, the role of ictal hypoperfusion remains poorly understood. The goal of this study was to systematically
-
Imaging the fasciculating motor unit Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-22 Michael Swash, Mamede de Carvalho
-
Long-term findings on working memory neural dynamics in healthcare workers after mild COVID-19 Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-22 David Ferrera, Diego Galán, Irene Peláez, Alberto Carpio, María Carmen Martín-Buro, Francisco Mercado
Understanding the long-term impact of Coronavirus Disease 2019 (COVID-19) on cognitive function, even in mild cases, is critical to the well-being of individuals, especially for healthcare workers who are at increased risk of exposure to the virus. To the best of our knowledge, the electrophysiological activity underlying cognitive functioning has not yet been explored. Seventy-seven healthcare workers
-
Neural control of blinking Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-22 Matteo Bologna, Giulia Paparella, Josep Valls-Solé, Mark Hallett, Alfredo Berardelli
Blinking is a motor act characterized by the sequential closing and opening of the eyelids, which is achieved through the reciprocal activation of the orbicularis oculi and levator palpebrae superioris muscles. This stereotyped movement can be triggered reflexively, occur spontaneously, or voluntarily initiated. During each type of blinking, the neural control of the antagonistic interaction between
-
Impacts of education level on Montreal Cognitive Assessment and saccades in community residents from Western China Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-21 Hua Li, Anjiao Peng, Wanlin Lai, Junru Wu, Shuming Ji, Dan Hu, Shujuan Chen, Chenxing Zhu, Qiulei Hong, Mingsha Zhang, Lei Chen
-
Single-channel qEEG characteristics distinguish delirium from no delirium, but not postoperative from non-postoperative delirium Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-20 D.Y. Lodema, F.L. Ditzel, S.C.A. Hut, E. van Dellen, W.M. Otte, A.J.C. Slooter
This exploratory study examined quantitative electroencephalography (qEEG) changes in delirium and the use of qEEG features to distinguish postoperative from non-postoperative delirium. This project was part of the DeltaStudy, a cross-sectional,multicenterstudy in Intensive Care Units (ICUs) and non-ICU wards. Single-channel (Fp2-Pz) four-minutes resting-state EEG was analyzed in 456 patients. After
-
Visual evoked potentials in multiple sclerosis: P100 latency and visual pathway damage including the lateral geniculate nucleus Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-20 Athina Papadopoulou, Armanda Pfister, Charidimos Tsagkas, Laura Gaetano, Shaumiya Sellathurai, Marcus D'Souza, Nuria Cerdá-Fuertes, Konstantin Gugleta, Maxime Descoteaux, Mallar M. Chakravarty, Peter Fuhr, Ludwig Kappos, Cristina Granziera, Stefano Magon, Till Sprenger, Martin Hardmeier
To explore associations of the main component (P100) of visual evoked potentials (VEP) to pre- and postchiasmatic damage in multiple sclerosis (MS). 31 patients (median EDSS: 2.5), 13 with previous optic neuritis (ON), and 31 healthy controls had VEP, optical coherence tomography and magnetic resonance imaging. We tested associations of P100-latency to the peripapillary retinal nerve fiber layer (pRNFL)
-
Spontaneous blink-related beta power increase and theta phase reset in subthalamic nucleus of Parkinson patients during walking Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-19 Liyu Cao, Chiara Palmisano, Xinyu Chen, Ioannis U. Isaias, Barbara F. Händel
Both blinking and walking are altered in Parkinson’s disease and both motor outputs have been shown to be linked in healthy subjects. Additionally, studies suggest an involvement of basal ganglia activity and striatal dopamine in blink generation. We investigated the role of the basal ganglia circuitry on spontaneous blinking and if this role is dependent on movement state and striatal dopamine. We
-
The Headshake Enhances Oculomotor Response to Galvanic Vestibular Stimulation in Healthy Subjects Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-19 Maja Striteska, Jan Kremlacek
To investigate whether a headshake applied during galvanic vestibular stimulation (GVS) can enhance GVS-induced nystagmus in healthy subjects. In nineteen healthy participants, we evaluated an average slow-phase velocity (aSPV) of nystagmus in a head-still and after the headshake conditions, with/out the bitemporal 2mA GVS. The GVS was applied also with polarity congruent (supporting) or incongruent
-
Timing matters for accurate identification of the epileptogenic zone Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-18 Bartlomiej Chybowski, Petr Klimes, Jan Cimbalnik, Vojtech Travnicek, Petr Nejedly, Martin Pail, Laure Peter-Derex, Jeff Hall, François Dubeau, Pavel Jurak, Milan Brazdil, Birgit Frauscher
Interictal biomarkers of the epileptogenic zone (EZ) and their use in machine learning models open promising avenues for improvement of epilepsy surgery evaluation. Currently, most studies restrict their analysis to short segments of intracranial EEG (iEEG). We used 2381 hours of iEEG data from 25 patients to systematically select 5-minute segments across various interictal conditions. Then, we tested
-
Maternal COVID-19 during third trimester pregnancy does not alter brain-stem auditory evoked potentials in infants Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-18 Lena Verdaguer, Daniela I. Santa-Cruz, M Angeles Sanchez Roldán, Vanessa Thonon, Marie Antoinette Frick, Kimia Rahnama, Ignacio Rubio Agusti, Dulce Moncho
-
Signatures of Migraine Aura in High-Density-EEG Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-18 Franz Riederer, Johannes Beiersdorf, Clemens Lang, Agnes Pirker-Kees, Antonia Klein, Adrian Scutelnic, Kirsten Platho-Elwischger, Christoph Baumgartner, Jens P. Dreier, Christoph Schankin
Cortical spreading depolarization is highly conserved among the species. It is easily detectable in direct cortical surface recordings and has been recorded in the cortex of humans with severe neurological disease. It is considered the pathophysiological correlate of human migraine aura, but direct electrophysiological evidence is still missing. As signatures of cortical spreading depolarization have
-
StairFit MUNE: A free and open source Matlab program for CMAP scan processing Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-18 Maoqi Chen, Ping Zhou
-
Whole-body fasciculation detection in amyotrophic lateral sclerosis using motor unit MRI (MUMRI) Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-18 Linda Heskamp, Matthew G. Birkbeck, Julie Hall, Ian.S. Schofield, James Bashford, Timothy L. Williams, Hugo M. De Oliveira, Roger G. Whittaker, Andrew M. Blamire
[Display omitted]
-
Vagus Nerve Stimulation and Heart Rate Variability: A Scoping Review of a Somatic Oscillatory Signal Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-16 Caitlin R Wessel, Cemal Karakas, Zulfi Haneef, Ian Mutchnick
The goal of this review is to synthesize the literature on vagus nerve stimulator (VNS)-related changes in heart rate variability (HRV) in patients with drug-resistant epilepsy (DRE) and assess the role of these changes in seizure relief. A scoping literature review was performed with the following inclusion criteria: primary articles written in English, involved implantable VNS in humans, and had
-
Delays in latencies of median-nerve evoked magnetic fields in patients with succinic semialdehyde dehydrogenase deficiency Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-16 Teppei Matsubara, Sheraz Khan, Padmavathi Sundaram, Steven Stufflebeam, Deniz Aygun, Melissa DiBacco, Jean-Baptiste Roullet, Phillip L. Pearl, Yoshio Okada
Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a genetic disorder resulting in abnormal regulation of γ-aminobutyric acid, lipid metabolism, and myelin biogenesis, leading to ataxia, seizures, and cognitive impairment. Since the myelin sheath is thinner in a murine model of SSADHD compared to a wild type, we hypothesized that this also holds for human brain. We tested whether the conduction
-
Impact of intracranial subclinical seizures on seizure outcomes after SLAH in patients with mesial temporal lobe epilepsy Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-15 Taixin Sun, Shasha Wu, Xi Liu, James X. Tao, Qun Wang
To investigate the association between subclinical seizures detected on intracranial electroencephalographic (i-SCSs)recordings and mesial temporal sclerosis (MTS), as well as their impact on surgical outcomes of stereotactic laser amygdalohippocampotomy (SLAH). A retrospective review was conducted on 27 patients with drug-resistant mesial temporal lobe epilepsy (MTLE) who underwent SLAH. The number
-
Association of Brain Functional Connectivity with Neurodevelopmental Outcomes in Healthy Full-Term Newborns Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-15 Venkata C Chirumamilla, Laura Hitchings, Sarah B. Mulkey, Tayyba Anwar, Robin Baker, G. Larry Maxwell, Josepheen De Asis-Cruz, Kushal Kapse, Catherine Limperopoulos, Adre du Plessis, R.B. Govindan
To study the association between neurodevelopmental outcomes and functional brain connectivity (FBC) in healthy term infants. This is a retrospective study of prospectively collected High-density electroencephalography (HD-EEG) from newborns within 72 hours from birth. Developmental assessments were performed at two years of age using the Bayley Scales of Infant Development-III (BSID-III) measuring
-
High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-15 Manyoel Lim, Dajung J. Kim, Thiago D. Nascimento, Alexandre F. DaSilva
This study investigated how high-definition transcranial direct current stimulation (HD-tDCS) over the primary motor cortex (M1) affects brain signal variability and functional connectivity in the trigeminal pain pathway, and their association with changes in migraine attacks. Twenty-five episodic migraine patients were randomized for ten daily sessions of active or sham M1 HD-tDCS. Resting-state
-
Erratum to “Aging alters functional connectivity of motor theta networks during sensorimotor reactions” [Clin. Neurophysiol. 158 (2024) 137–148] Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-12 Juliana Yordanova, Michael Falkenstein, Vasil Kolev
-
Atypical beta-band effects in children with dyslexia in response to rhythmic audio-visual speech Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-10 Mahmoud Keshavarzi, Kanad Mandke, Annabel Macfarlane, Lyla Parvez, Fiona Gabrielczyk, Angela Wilson, Usha Goswami
Previous studies have reported atypical delta phase in children with dyslexia, and that delta phase modulates the amplitude of the beta-band response via delta-beta phase-amplitude coupling (PAC). Accordingly, the atypical delta-band effects in children with dyslexia may imply related atypical beta-band effects, particularly regarding delta-beta PAC. Our primary objective was to explore beta-band oscillations
-
rTMS of the auditory association cortex improves speech intelligibility in patients with sensorineural hearing loss Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Francesco Neri, Chiara Cappello, Francesca Viberti, Aniello Donniacuo, Lucia Burzi, Alessandra Cinti, Alberto Benelli, Carmelo Luca Smeralda, Sara Romanella, Emiliano Santarnecchi, Marco Mandalà, Simone Rossi
Sensorineural hearing-loss (SHL) is accompanied by changes in the entire ear-brain pathway and its connected regions. While hearing-aid (HA) partially compensates for SHL, speech perception abilities often continue to remain poor, resulting in consequences in everyday activities. Repetitive-Transcranial-Magnetic-Stimulation (rTMS) promotes cortical network plasticity and may enhance language comprehension
-
Distinct MRI-based functional and structural connectivity for antidepressant response prediction in major depressive disorder Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Xinyi Wang, Li Xue, Junneng Shao, Zhongpeng Dai, Lingling Hua, Rui Yan, Zhijian Yao, Qing Lu
Emerging studies have identified treatment-related connectome predictors in major depressive disorder (MDD). However, quantifying treatment-responsive patterns in structural connectivity (SC) and functional connectivity (FC) simultaneously remains underexplored. We aimed to evaluate whether spatial distributions of FC and SC associated treatment responses are shared or unique. Diffusion tensor imaging
-
Neural Correlates of Impaired Learning and Recognition of Novel Faces in Mild Cognitive Impairment Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Tianjiao Zhang, Tingni Li, Sisi Huang, Hangbin Zhang, Xingjun Xu, Hui Zheng, Qian Zhong, Yaxin Gao, Tong Wang, Yi Zhu, Hanjun Liu, Ying Shen
Face memory impairment significantly affects social interactions and daily functioning in individuals with mild cognitive impairment (MCI). While deficits in recognizing familiar faces among individuals with MCI have been reported, their ability to learn and recognize unfamiliar faces remains unclear. This study examined the behavioral performance and event-related potentials (ERPs) of unfamiliar face
-
Progression of axonal excitability abnormalities with increasing clinical severity of diabetic peripheral neuropathy Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Roshan Dhanapalaratnam, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Natalie CG. Kwai, Arun V. Krishnan
Diabetic peripheral neuropathy (DPN) is a frequent complication for persons with type 2 diabetes. Previous studies have failed to demonstrate any significant impact of treatment for DPN. The present study assessed the role of axonal ion channel dysfunction in DPN and explored the hypothesis that there may be a progressive change in ion channel abnormalities that varied with disease stage. Neurophysiological
-
The corticospinal system and ALS Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Roger Lemon
Corticospinal neurons located in motor areas of the cerebral neocortex project corticospinal axons which synapse with the spinal network; a parallel corticobulbar system projects to the cranial motor network and to brainstem motor pathways. The primate corticospinal system has a widespread cortical origin and an extensive range of different fibre diameters, including thick, fast-conducting axons. Direct
-
Impaired post-sleep apnea autonomic arousals in patients with drug-resistant epilepsy Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 François Ricordeau, Florian Chouchou, Vincent Pichot, Frédéric Roche, Thierry Petitjean, Frédéric Gormand, Hélène Bastuji, Eléna Charbonnier, Pierre Le Cam, Emeric Stauffer, Sylvain Rheims, Laure Peter-Derex
Sudden and unexpected deaths in epilepsy (SUDEP) pathophysiology may involve an interaction between respiratory dysfunction and sleep/wake state regulation. We investigated whether patients with epilepsy exhibit impaired sleep apnea-related arousals. Patients with drug-resistant (N=20) or drug-sensitive (N=20) epilepsy and obstructive sleep apnea, as well as patients with sleep apnea but without epilepsy
-
The blink reflex and its modulation – Part 2: Pathophysiology and clinical utility Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-09 Aysegul Gunduz, Josep Valls-Solé, Tereza Serranová, Gianluca Coppola, Markus Kofler, Satu K. Jääskeläinen
The blink reflex (BR) is integrated at the brainstem; however, it is modulated by inputs from various structures such as the striatum, globus pallidus, substantia nigra, and nucleus raphe magnus but also from afferent input from the peripheral nervous system. Therefore, it provides information about the pathophysiology of numerous peripheral and central nervous system disorders. The BR is a valuable
-
Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-08 Antonia S. Carroll, Susanna B. Park, Cindy S.Y. Lin, Mark S. Taylor, Fiona Kwok, Neil G Simon, Mary M. Reilly, Matthew C. Kiernan, Steve Vucic
The treatment of hereditary transthyretin amyloidosis polyneuropathy (ATTRv-PN) has been revolutionised by genetic therapies, with dramatic improvements in patient outcomes. Whilst the optimal timing of treatment initiation remains unknown, early treatment is desirable. Consequently, the aim of the study was to develop biomarkers of early nerve dysfunction in ATTRv-PN. Ulnar motor and sensory axonal
-
-
-
Nerve ultrasound in Friedreich’s Ataxia: enlarged nerves as a biomarker of disease severity Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-02 G. Di Pietro, E. Cioffi, P. Falco, E. Galosi, G. De Stefano, G. Di Stefano, C. Leone, V. Martines, S. Perotti, C. Casali, A. Truini
In Friedreich's ataxia research, the focus is on discovering treatments and biomarkers to assess disease severity and treatment effects. Our study examines high-resolution nerve ultrasound in these patients, seeking correlations with established clinical markers of disease severity. Ten patients with Friedreich’s Ataxia underwent a comprehensive clinical assessment with established scales (SARA, FARS
-
Single-trial EEG analysis reveals burst structure during photic driving Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-02-02 Hannes Oppermann, Antonia Thelen, Jens Haueisen
Photic driving in the human visual cortex evoked by intermittent photic stimulation is usually characterized in averaged data by an ongoing oscillation showing frequency entrainment and resonance phenomena during the course of stimulation. We challenge this view of an ongoing oscillation by analyzing unaveraged data. 64-channel EEGs were recorded during visual stimulation with light flashes at eight
-
Network alterations in temporal lobe epilepsy during non-rapid eye movement sleep and wakefulness Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-01-30 I Rigoni, BJ Vorderwülbecke, M Carboni, N Roehri, L Spinelli, G Tononi, M Seeck, L Perogamvros, S Vulliémoz
Objective Investigate sleep and temporal lobe epilepsy (TLE) effects on brain networks derived from electroencephalography (EEG). Methods High-density EEG was recorded during non-rapid eye movement (NREM) sleep stage 2 (N2) and wakefulness in 23 patients and healthy controls (HC). Epochs without epileptic discharges were source-reconstructed in 72 brain regions and connectivity was estimated. We calculated
-
P-43 Stiripentol protects against cerebral ischemia reperfusion injury in a mouse model of transient middle cerebral artery occlusion Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-01-21 G. Reichart, H. Weisbecker, T. Sellmann, X. Guli, C. Zehm, A. Einsle, F. Lange, T. Kirschstein, R. Köhling
-
P-44 Nerve ultrasound in the early phase of chemotherapy-induced polyneuropathy Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-01-21 M. Katz, M. Knaup, H. Mork, T. Jasmin, P. Schellinger, J. Philipps
-
-
Probing intrahemispheric interactions with a novel dual-site TMS setup Clin. Neurophysiol. (IF 4.7) Pub Date : 2024-01-05 Melina Hehl, Shanti Van Malderen, Marc Geraerts, Raf L.J. Meesen, John C. Rothwell, Stephan P. Swinnen, Koen Cuypers
Objective Using dual-site transcranial magnetic stimulation (dsTMS), the effective connectivity between the primary motor cortex (M1) and adjacent brain areas such as the dorsal premotor cortex (PMd) can be investigated. However, stimulating two brain regions in close proximity (e.g., ±2.3 cm for intrahemispheric PMd–M1) is subject to considerable spatial restrictions that potentially can be overcome