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The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia) Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-13 Xinmao Tian, Zishi Wang, Yuhua Shi, Chongchong Jia, Xiujuan Li, Mengke Li, Haowei Liu, Zhenlong Wang
The lateral hypothalamic nucleus (LHy) is located in the dorsolateral hypothalamus of birds, and it is essential to many life processes. However, limited information is available about the role of LHy in mediating locomotive behaviors. In this work, we investigated the structure and function of LHy in pigeons () by Nissl staining, immunohistochemical (IHC) staining, insituhybridization (ISH) staining
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PREFRONTAL ACTIVITY DURING IOWA GAMBLING TASK IN YOUNG ADULT WOMEN Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-13 Ferran Balada, Anton Aluja, Oscar García, Neus Aymamí, Luis F. García
This study aims to investigate the relationships between personality traits of impulsivity, using the UPPS-P Impulsive Behaviour Scales shortened version, and prefrontal cortex (PFC) activity during the IOWA Gambling Task (IGT) in young adult women. The study included a sample of 83 young, healthy females (19.8 ± 1.4 years), who voluntarily took part in the study. Repeated measures analysis during
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Neuroprotective effects of platinum nanoparticle-based microreactors in bicuculline-induced seizures Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-12 Roberto N. Oliveira, Patrícia S. Carvalhinho-Lopes, Carolina P.F. Carvalho, Rafael Y.S. Hirata, Sandra H. Vaz, Ana Maria Sebastião, Adam Armada-Moreira, Bárbara A. Rosário, Jéssica A. Lemes, Beatriz Soares-Silva, José S. de Andrade, José Ronaldo Santos, Alessandra M. Ribeiro, Milena B. Viana
Epilepsy designates a group of chronic brain disorders, characterized by the recurrence of hypersynchronous, repetitive activity, of neuronal clusters. Epileptic seizures are the hallmark of epilepsy. The primary goal of epilepsy treatment is to eliminate seizures with minimal side effects. Nevertheless, approximately 30% of patients do not respond to the available drugs. An imbalance between excitatory/inhibitory
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Chronic MK-801 administration provokes persistent deficits in social memory in the prairie vole (Microtus ochrogaster): a potential animal model for social deficits of schizophrenia Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-12 Enrique Basurto, Oscar González-Flores, Kurt Hoffman
The prairie vole () is a rodent species that has been used extensively to study biological aspects of human social bonding. Nevertheless, this species has not been studied in the context of modeling social deficits characteristic of schizophrenia. Building on studies in rodents that show that sub-chronic administration of an NMDA receptor antagonist induces persistent behavioral and neurological characteristics
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One-trial odour recognition learning and its underlying brain areas in the zebrafish Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-11 Tyrone Lucon-Xiccato, Gaia De Russi, Elena Frigato, Marco Dadda, Cristiano Bertolucci
Distinguishing familiar from novel stimuli is critical in many animals’ activities, and procedures based on this ability are among the most exploited in translational research in rodents. However, recognition learning and the underlying brain substrates remain unclear outside a few mammalian species. Here, we investigated one-trial recognition learning for olfactory stimuli in a teleost fish using
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Neural correlates of inhibitory control in the context of infant cry and paternal postpartum mental health Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-08 Yael Waizman, Ellen Herschel, Sofia I. Cárdenas, Anthony G. Vaccaro, Elizabeth C. Aviv, Pia E. Sellery, Diane Goldenberg, Jonas Kaplan, Darby E. Saxbe
Inhibitory control, a form of self-regulation, may support sensitive parenting, but has been understudied in new fathers despite their pronounced risk for stress and mental health challenges. This study probed the neural correlates of inhibitory control and its associations to first-time fathers' postpartum mental health, focusing on depressive symptoms, state anxiety, and perceived stress. Six months
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The cerebellum and its connections to other brain structures involved in motor and non-motor functions: a comprehensive review Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-06 José Mário Prati, André Pontes-Silva, Anna Carolyna Lepesteur Gianlorenço
The cerebellum has a large network of neurons that communicate with several brain structures and participate in different functions. Recent studies have demonstrated that the cerebellum is not only associated with motor functions but also participates in several non-motor functions. It is suggested that the cerebellum can modulate behavior through many connections with different nervous system structures
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Effects of sensory afferent input on motor cortex excitability of agonist and antagonist muscles Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-06 Kenichi Sugawara, Yuma Takenaka, Tomotaka Suzuki
In this study, we aimed to analyze control mechanisms of short-latency afferent inhibition (SAI) during motor output exertion from an agonist or antagonist muscle. The motor task involved index finger abduction (agonist) and adduction (antagonist). In Experiment 1, motor-evoked potentials (MEPs) were recorded from the first dorsal interosseous (FDI) muscle with and without SAI at three output force
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Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-05 Xiaofeng Tian, Zhixing Zhao, Jing Zhao, Dongmei Su, Bin He, Cuige Shi, Ying Shi
The normal aging process is accompanied by cognitive decline, and previous studies have indicated the crucial role of the hypothalamus in regulating both aging and cognition. However, the precise molecular mechanism underlying this relationship remains unclear. Therefore, this present study aimed to identify potential predictors of cognitive decline associated with aging specifically within the hypothalamus
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Acrobatic training prevents motor deficits and neuronal loss in male and female rats following chronic cerebral hypoperfusion. Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-05 Ana Paula Rodrigues Martini, Eduarda Hoeper, Débora Piassarollo Dos Santos, Tatiana Norman, Adriana Souza dos Santos, Lenir Orlandi Pereira, Carlos Alexandre Netto
Chronic cerebral hypoperfusion in vascular dementia leads to memory and motor deficits; Physical exercise improves these aspects and promotes neuroprotection. Sexual dimorphism may significantly influence both ischemic and exercise outcomes. The aim of this study was to investigate the effects of 2VO (Two-Vessel occlusion) and the acrobatic training on motor function, functional performance, and tissue
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TEMPORARY REMOVAL: Pro-inflammatory markers are related to cortical network connectivity in women exposed to interpersonal trauma with PTSD Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-04 Marissa A. Yetter, Taryn R. Fitzgerald, Carissa L. Philippi, Steven E. Bruce
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Quercetin attenuates brain apoptosis in mice with chronic unpredictable mild stress-induced depression Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Chenjie Ge, Shiliang Wang, Xuqi Wu, Lilei Lei
Depression is a common psychiatric disorder with limited effective treatments. Research suggests that depression involves apoptosis mechanisms. Quercetin (QUE) has been reported to have anti-apoptotic activities. In this study, we aimed to investigate the effects and mechanisms of QUE in chronic unpredictable mild stress (CUMS)-induced depression. After establishing mouse models of CUMS-induced depression
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Beauty is in the nose of the beholder: Fragrance modulates attractiveness, confidence and femininity ratings and neural responses to faces of self and others Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Jennifer Davies-Owen, Hannah Roberts, Margaret Scott, Anna Thomas, Soumitra Sen, Simone Sethna, Carl Roberts, Timo Giesbrecht, Nicholas Fallon
Previous research investigated cross-modal influence of olfactory stimuli on perception and evaluation of faces. However, little is known about the neural dynamics underpinning this multisensory perception, and no research examined perception for images of oneself, and others, in presence of fragrances. This study investigated the neural mechanisms of olfactory-visual processing using electroencephalography
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Effects of chronic unpredictable mild stress on gut microbiota and fecal amino acid and short-chain fatty acid pathways in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Mengjing Chen, Lingfeng Wang, Yeliang Lou, Zhen Huang
Depression is a serious disease that has a significant impact on social functioning. However, the exact causes of depression are still not fully understood. Therefore, it is necessary to explore new pathways leading to depression. In this study, we used 16 S rDNA to examine changes in gut microbiota and predict related pathways in depression-like mice. Additionally, we employed liquid chromatography-mass
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Father’s Absence in the Mongolian gerbil (Meriones unguiculatus) is associated with alterations in paternal behavior, T, cort, presence of ERα, and AR in mPOA/ BNST Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-01 Brenda García-Saucedo, Luis Romero-Morales, Carmen Álvarez-Rodríguez, René Cárdenas-Vázquez, María Rosa Ávila-Costa, Juana Luis
Testosterone (T), estrogen receptor alpha (ERα), and androgen receptor (AR) play a significant role in the regulation of paternal behavior. We determined the effects of deprivation of paternal care on alterations in paternal behavior, T concentrations in plasma, and the presence of ERα and AR in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA), and
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Electrophysiological indexes of ingroup bias in a group Stroop task: Evidence from an event-related potential study Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-01 Jiashan Sima, Huanke Ma, Fan Liu, Chenjun Lou, Feng Zou, Yufeng Wang, Yanyan Luo, Meng Zhang, Xin Wu
Although cognitive system assigns higher attentional resources to ingroup information than outgroup information, but it is unclear whether the ingroup bias can be measured by the processes that are related to allocation of attentional resources to ingroup information. Thus, a group Stroop task was developed to study the issues combining with event-related potential (ERP) technique in this study. Specifically
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Synergistic effects of citicoline and silymarin nanomicelles in restraint stress-exposed mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Elham Shayan, Fatemeh Maheri, Fatemeh Aflaki, Seyyedeh-Elaheh Mousavi, Mohammad-Reza Zarrindast, Nahid Fakhraei, Seyyed-Mahdi Rezayat Sorkhabadi, Seyed-Mohammad-Masoud Shushtarian
This study evaluated the effects of citicoline and silymarin nanomicelles (SMnm) in repeated restraint stress (RRS). Mice were exposed to RRS for four consecutive days, 2 hrs. daily. On day 5 of the study, SMnm (25 and 50 mg/kg, i.p.) and citicoline (25 and 75 mg/kg), and a combination of them (25 mg/kg, i.p.) were initiated. On day 18, anxiety-like behavior, behavioral despair, and exploratory behavior
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Genetic causal association between varicella-zoster virus infection and psychiatric disorders: A 2-sample Mendelian randomization study Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Bo Yan, Pan Liao, Conglin Wang, Zhaoli Han, Fangyuan Cheng, Ping Lei
Psychiatric disorders, such as schizophrenia (SCZ), major depressive (MDD), and bipolar disorder (BD) have a profound impact on millions of individuals worldwide. The critical step toward developing effective preventive and treatment strategies lies in comprehending the causal mechanisms behind these diseases and identifying modifiable risk factors associated with them. In this study, we conducted
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Neural correlates of the addictions neuroclinical assessment (ANA) incentive salience factor among individuals with alcohol use disorder Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Steven J. Nieto, Erica N. Grodin, Lara A. Ray
The Addictions Neuroclinical Assessment (ANA) is a recently-developed framework offering a more holistic understanding of three neurofunctional and behavioral domains that reflect the neurobiological dysfunction seen in alcohol use disorder (AUD). While the ANA domains have been well-validated across independent laboratories, there is a critical need to identify neural markers that subserve the proposed
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Exposure to the psychedelic substance 25 H-NBOMe disrupts maternal care in lactating rats and subsequently impairs the social play behavior of the offspring Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-27 L.ídia M. Melo, Wellington A. de Barros, Ângelo de Fátima, Fabiana C.Vilela Giusti, Alexandre Giusti-Paiva
Given the critical role of maternal care in the neurodevelopment of offspring, this study aimed to investigate the effects of the psychedelic substance 25 H-NBOMe on maternal behavior in lactating rats and its subsequent impact on the social and neurodevelopmental behavior of the offspring. We administered two different dosages of 25 H-NBOMe (0.3 mg/kg and 1.0 mg/kg; i,p,) to lactating rats and observed
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Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-27 Shreya Desai, Clara G. Zundel, Julia M. Evanski, Leah C. Gowatch, Amanpreet Bhogal, Samantha Ely, Carmen Carpenter, MacKenna Shampine, Emilie O’Mara, Christine A. Rabinak, Hilary A. Marusak
The endocannabinoid system modulates neural activity throughout the lifespan. In adults, neuroimaging studies link a common genetic variant in fatty acid amide hydrolase ()—an enzyme that regulates endocannabinoid signaling—to reduced risk of anxiety and depression, and altered threat- and reward-related neural activity. However, limited research has investigated these associations during the transition
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The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role? Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Clarissa Penha Farias, Ana Karla Oliveira Leite, Bianca Estefani Schmidt, Jociane de Carvalho Myskiw, Angela T.S. Wyse
Studies on the social modulation of fear have revealed that in social species, individuals in a distressed state show better recovery from aversive experiences when accompanied - referred to as social buffering. However, the underlying mechanisms remain unknown, hindering the understanding of such an approach. Our previous data showed that the presence of a conspecific during the extinction task inhibited
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Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: Circadian anomalies and attentional vulnerability Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Concetto Puzzo, Fabiana Festucci, Giuseppe Curcio, Antonella Gigantesco, Walter Adriani
Dopamine (DA) is mainly involved in locomotor activity, reward processes and maternal behaviors. Rats with KO gene for dopamine transporter (DAT), coding for a truncated DAT protein, are in hyperdopaminergic conditions and thus develop stereotyped behaviors and hyperactivity. Our aim was to test the prior transgenerational modulation of wild and truncated alleles as expressed in heterozygous DAT rats:
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Age dependent path integration deficit in 5xFAD mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Kendall D. Mar, Chanbee So, Yixin Hou, Jun Chul Kim
Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common form of dementia in elderly individuals, characterized by memory deficits, cognitive decline, and neuropathology. The identification of preclinical markers for AD remains elusive. We employed an ultrasound-evoked spatial memory assay to investigate path integration (PI) in wild type C57BL/6 J and 5xFAD mice. We observed
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Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Carissa L. Philippi, Emily Weible, Alissa Ehlers, Erin C. Walsh, Roxanne M. Hoks, Rasmus M. Birn, Heather C. Abercrombie
Abnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system have been implicated in depression. Studies have reported glucocorticoid insensitivity and reduced heart rate variability (HRV) in depressive disorders. However, little is known about the effects of cortisol on HRV and resting-state functional connectivity (rsFC) of the central autonomic network (CAN) in
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Influence of a placebo tDCS treatment on Cybersickness and EEG-Neurofeedback success Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-23 Lisa Maria Berger, Guilherme Wood, Silvia Erika Kober
Virtual Reality (VR) serves as a modern and powerful tool within the domain of neurofeedback (NF). Users can learn how to alter their own brain activation with the help of NF, for example visual feedback. VR can help to make the training more engaging and motivating with its immersive nature. However, cybersickness (CS) poses a serious problem, as it negatively affects up to 80% of all VR users. Especially
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Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-23 Kazuo Okanari, Hitoshi Teranishi, Ryohei Umeda, Kenshiro Shikano, Masanori Inoue, Toshikatsu Hanada, Kenji Ihara, Reiko Hanada
Epilepsy, a recurrent neurological disorder involving abnormal neurotransmitter kinetics in the brain, has emerged as a global health concern. The mechanism of epileptic seizures is thought to involve a relative imbalance between excitatory and inhibitory neurotransmitters. Despite the recent advances in clinical and basic research on the pathogenesis of epilepsy, the complex relationship between the
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Analysis of visual discrimination in Japanese eel (Anguilla japonica) Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-23 S, h, i, g, e, r, u, , W, a, t, a, n, a, b, e
Japanese eels were trained to discriminate between a checkerboard panel and a plain gray panel in a circular pool with three pipes. One of the pipes was open, whereas the others were closed. The correct choice of discriminative stimulus was reinforced by entering the pipe. When the panels were displayed vertically (on the wall), the eels successfully learned discrimination, but they were unable to
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Sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-21 Shaohua You, Yishuang Wu, Yongxin Guo, Meng Wu, Mingzi Ran, Fuyang Cao, Xinyu Hao, Lujia Yang, Hong Zhang, Weidong Mi, Li Tong
Depression has emerged as the predominant psychiatric affliction affecting individuals. Prior research has substantiated the antidepressant properties exhibited by numerous anesthetics. Sevoflurane, a widely utilized inhalant anesthetic in clinical practice, remains relatively uncharted in terms of its specific antidepressant effects. In this study, we used open field test, forced swimming test and
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A generative adaptive convolutional neural network with attention mechanism for driver fatigue detection with class-imbalanced and insufficient data Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-19 Le He, Li Zhang, Qiang Sun, XiangTian Lin
Over the past few years, fatigue driving has emerged as one of the main causes of traffic accidents, necessitating the development of driver fatigue detection systems. However, many existing methods involves tedious manual parameter tunings, a process that is both time-consuming and results in task-specific models. On the other hand, most of the researches on fatigue recognition are based on class-balanced
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Characterizing the dynamic learning process: Implications of a quantitative analysis Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-17 Meilin Wu, Fuhong Liu, Hao Wang, Li Yao, Chunling Wei, Qiaohua Zheng, Jing Han, Zhiqiang Liu, Yihui Liu, Haijun Duan, Wei Ren, Zongpeng Sun
Understanding the neural mechanisms involved in learning processes is crucial for unraveling the complexities of behavior and cognition. Sudden change from the untrained level to the fully-learned level is a pivotal feature of instrumental learning. However, the concept of change point and suitable methods to conveniently analyze the characteristics of sudden change in groups remain elusive, which
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Blocking the dopaminergic receptors within the hippocampal dentate gyrus reduced analgesic responses induced by restraint stress in the formalin test Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-16 Farzaneh Nazari-Serenjeh, Mehdi Sadeghi, Ronak Azizbeigi, Hadi Semizeh, Sajad Mazaheri, Amir Haghparast, Abbas Haghparast
Previous studies have shown that various receptors, including dopamine receptors, are expressed in the hippocampal dentate gyrus (DG). Besides, indicatively, dopamine receptors play an essential role in the modulation of pain perception. On the other hand, stressful experiences can produce analgesia, termed stress-induced analgesia (SIA). The current study examined the probable role of dopamine receptors
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High stability of EEG spectral power across polysomnography and multiple sleep latency tests in good sleepers and chronic insomniacs Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-15 Yuan Shi, Rong Ren, Ye Zhang, Haipeng Zhang, Xujun Feng, Larry D. Sanford, Xiangdong Tang
To assess the stability of electroencephalographic (EEG) spectral features across overnight polysomnography (PSG) and daytime multiple sleep latency tests (MSLTs) in chronic insomniacs (CIs) and normal controls (NCs). A total of 20 NCs and 22 CIs underwent standard PSG and MSLTs. Spectral analyses were performed on EEG data from PSG and MSLTs and absolute and relative power in central, frontal and
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Cross-cultural differences in prefrontal cortex activity in moral judgment: A functional near-infrared spectroscopy (fNIRS) study based on the CNI model Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-13 Yachun Qian, Yoshiyuki Takimoto, Akira Yasumura
In the past, comparative cultural neurological studies of moral judgments have mainly focused on Eastern and Western groups. We initially examined Japanese and Chinese groups, both East Asian cultures. We utilized a recently proposed polynomial model known as the “consequences, norms, and generalized inaction” (CNI) model to investigate the variations in the overall prefrontal cortex activity between
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Line- and sex-dependent effects of juvenile stress on contextual fear- and anxiety-related behavior in high- and low-alcohol-preferring mouse lines Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-10 Arbaaz A. Mukadam, Julia A. Chester
Juvenile stress (JS) is a known risk factor for the development of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD), both of which are frequently co-morbid. Data suggest there may be common, genetically-influenced biological responses to stress that contribute to the development of both AUD and PTSD. The present study investigated the impact of JS on contextual fear learning and
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Oral administration of bacterial probiotics improves Helicobacter pylori-induced memory impairment in rats: Insights from behavioral and biochemical investigations Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-09 Nazanin Sadat Seddighi, Farimah Beheshti, Maha Masoudi, Amir Mohammad Ali Tabrizi, Ahad Ali Harati Asl, S. Mohammad Ahmadi-Soleimani, Omid Azizi
There are numerous evidence supporting the association between () infection and the occurrence of cognitive deficits in humans. In this regard, treatment of infection has been suggested as an effective strategy to decelerate the neurodegenerative processes of memory deficits in AD patients. Numerous studies support the beneficial effects of probiotics on various pathological conditions, particularly
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Pros and cons of narrow- versus wide-compartment rotarod apparatus: An experimental study in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-09 Sachiko P. Keane, Kathryn K. Chadman, Andres R. Gomez, Wen Hu
The rotarod test, a sensorimotor assessment that allows for quantitative evaluation of motor coordination in rodents, has extensive application in many research fields. The test results exhibit extreme between-study variability, sometimes making it challenging to conclude the validity of certain disease models and related therapeutic effects. Although the variation in test paradigms may account for
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Physical training improves inhibitory control in children aged 7–12 years: An fNIRS study Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-09 Xiaoke Zhong, Chen Wang, Mingchao Xu, Xiaoxia Yuan, Changhao Jiang
Physical exercise plays a crucial role in the development of cognition and brain functions in children. Inhibitory control is an advanced cognition that affects children's life and learning. In the current study, the relationship between physical training and inhibitory control was explored. In total, 80 children were randomly but equally assigned to the experimental and control groups. The experimental
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Longitudinal MRI analysis using a hybrid DenseNet-BiLSTM method for Alzheimer's disease prediction Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-08 Alireza Jomeiri, Ahmad Habibizad Navin, Mahboubeh Shamsi
Alzheimer's disease is a progressive neurological disorder characterized by brain atrophy and cell death, leading to cognitive decline and impaired functioning. Previous research has primarily focused on using cross-sectional data for Alzheimer's disease identification, but analyzing longitudinal sequential MR images is crucial for improved diagnostic accuracy and understanding disease progression
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Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-07 Asiye Nurten, M. Zafer Gören, Nurdan Tekin, Mert Kaşkal, Nurhan Enginar
Tamoxifen has been shown to reduce glutamate release from presynaptic glutamatergic nerves and reverse tolerance to morphine-induced respiratory depression. Changes in glutamatergic neurotransmission in the central nervous system contribute to morphine tolerance, dependence, and withdrawal. This study, therefore, evaluated effects of tamoxifen on development of analgesic tolerance and dependence, and
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Inhibitory effects of β-asarone on lncRNA BACE1-mediated induction of autophagy in a model of Alzheimer’s disease Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-04 Zhifang Wang, Jingpei Zhou, Bin Zhang, Zhanqiong Xu, Haoyu Wang, Quan Sun, Nanbu Wang
The primary aim of this study was to examine the correlation between the formation of Aβ plaques and autophagy, which is regulated by β-asarone and the lncRNA BACE1-AS. Additionally, the study sought to explore potential targets of the drug in inhibiting the deposition of toxic AD-related proteins and restoring impaired mitochondrial and autophagic functions. SHY5Y cells were utilized to construct
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An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-03 Lindsey Wilson, McKenna Klausner, Stacey Chuang, Smruti Patel, Wayne E. Pratt
The nucleus accumbens (NAc) is a critical region for regulating the appetitive and consummatory aspects of motivated behavior. Previous work has shown differential effects of NAc µ-, δ-, and κ- receptor stimulation on food intake and for shifting motivation within an effort-based choice (EBC) task. However, the motivational role of the nociceptin opioid peptide (NOP) receptor, a fourth member of the
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Extensive functional connectivity between brain areas implicated in mental imagery production and phobic fear during both emotional and neutral mental imagery Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-03 Thomas Agren, Johanna M. Hoppe
Mental imagery is used by most people in their day-to-day cognition, for example, in planning, daydreaming, or remembering. Importantly, mental imagery has a powerful influence on emotion and is critically involved in many mental disorders. Thus, understanding the link between mental imagery and emotion is of clinical interest. For example, exposure therapy can be successfully conducted using mental
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The effects of orlistat on oxidative stress, recognition memory, spatial memory and hippocampal tissue in experimentally induced obesity in rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-03 Ayse Arzu Yigit, Sevtap Kilinc, Rukiye Olcuoglu, Elif Azra Arnous
This study investigates the impact of orlistat on oxidative stress, spatial memory, recognition memory, and hippocampal tissue in obese rats. The study groups were divided into control, high fat diet-induced obese (HFDIO), HFDIO+orlistat (HFDIO+ORL) groups, each consisting of 8 animals. While control fed with standart diet, HFDIO and HFDIO+ORL fed with high-fat diets for 8 weeks to induce obesity.
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Comparative analysis of the nucleus accumbens transcriptional features in multiple depressive animal models Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-02 Ying Yu, Xuemei Li, Teng Teng, Yuqian He, Yuanliang Jiang, Xueer Liu, Xinyu Zhou, Yong Luo, Peng Xie
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Mitophagy activation by rapamycin enhances mitochondrial function and cognition in 5×FAD mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-01 Wenrong Zheng, Kualiang Li, Meihua Zhong, Kejun Wu, Lele Zhou, Jie Huang, Libin Liu, Zhou Chen
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by severe mitochondrial dysfunction, which is an intracellular process that is significantly compromised in the early stages of AD. Mitophagy, the selective removal of damaged mitochondria, is a potential therapeutic strategy for AD. Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, augmented autophagy and mitigated
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Selective disruption of mTORC1 and mTORC2 in VTA astrocytes induces depression and anxiety-like behaviors in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-01 Ziteng Zheng, Han Zhou, Lu Yang, Lanlan Zhang, Ming Guo
Dysfunction of the mechanistic target of rapamycin (mTOR) signaling pathway is implicated in neuropsychiatric disorders including depression and anxiety. Most studies have been focusing on neurons, and the function of mTOR signaling pathway in astrocytes is less investigated. mTOR forms two distinct complexes, mTORC1 and mTORC2, with key scaffolding protein Raptor and Rictor, respectively. The ventral
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Olanzapine attenuates 5-HT2cR and GHSR1a interaction to increase orexigenic hypothalamic NPY: Implications for neuronal molecular mechanism of metabolic side effects of antipsychotics Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-01 Xiaoli Liu, Xia Lan, Xinyou Zhang, Huaiyu Ye, Lijun Shen, Minmin Hu, Xiaoqi Chen, Mingxuan Zheng, Katrina Weston-Green, Tiantian Jin, Xiaoying Cui, Yi Zhou, Xiangyu Lu, Xu-Feng Huang, Yinghua Yu
The main cause of second-generation antipsychotic (SGA)-induced obesity is considered due to the antagonism of serotonin 2c receptors (5-HT2cR) and activation of ghrelin receptor type 1a (GHSR1a) signalling. It is reported that 5-HT2cR interacted with GHSR1a, however it is unknown whether one of the SGA olanzapine alters the 5-HT2cR/GHSR1a interaction, affecting orexigenic neuropeptide signalling in
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Celiac disease and depressive disorders as nutritional implications related to common factors – A comprehensive review Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-01 Joanna Mikulska, Diana Pietrzak, Paweł Rękawek, Krystian Siudaj, Łucja Justyna Walczak-Nowicka, Mariola Herbet
Celiac disease (CD) is an immune-mediated disease affecting the small intestine. The only treatment strategy for CD is the gluten-free diet (GFD). One of the more common mental disorders in CD patients is major depressive disorder (MDD). The influence of GFD on the occurrence of MDD symptoms in patients with CD will be evaluated. This diet often reduces nutritional deficiencies in these patients and
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Acute taurine reduced alcohol intake and preference in alcohol-experienced, but not in alcohol-näive rats by central mechanisms Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-01 Abraham Miranda-Páez, Bruno Antonio Marichal-Cancino, Hugo Sánchez-Castillo, Priscila Vázquez-León
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Cerebral, systemic physiological and behavioral responses to colored light exposure during a cognitive task: A SPA-fNIRS study Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-29 Hamoon Zohdi, Josefa Märki, Felix Scholkmann, Ursula Wolf
Colored light has important implications for human health and well-being, as well as for the aesthetics and function of various environments. In addition to its effects on visual function, colored light has significant effects on cognitive performance, behavior and systemic physiology. The aim of the current study was to comprehensively investigate how colored light exposure (CLE) combined with a cognitive
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Contribution of the medial entorhinal cortex to performance on the Traveling Salesperson Problem in rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-26 Jena B. Hales, Larissa Olivas, Daniela Abouchedid, Rachel E. Blaser
In order to successfully navigate through space, animals must rely on multiple cognitive processes, including orientation in space, memory of object locations, and navigational decisions based on that information. Although highly-controlled behavioral tasks are valuable for isolating and targeting specific processes, they risk producing a narrow understanding of complex behavior in natural contexts
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Sex-dependent regulation of social avoidance by oxytocin signaling in the ventral tegmental area Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-24 Zachary A. Grieb, Susan Lee, Maura C. Stoehr, Benjamin W. Horne, Alisa Norvelle, Emma K. Shaughnessy, H. Elliott Albers, Kim L. Huhman
It has been hypothesized that oxytocin increases the salience of social stimuli, whether the valence is positive or negative, through its interactions with the ventral tegmental area (VTA). Indeed, oxytocin neurons project to the VTA and activate dopamine neurons that are necessary for social experiences with positive valence. Surprisingly, though, there has not been an investigation of the role of
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Behavioral effects of 6-hydroxydopamine-induced damage to nigro-striatal pathway and Locus coeruleus as a rodent model of Parkinson’s disease Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-23 Isabella B. Bustelli, Luiz M. Oliveira, Nelson F. Correa-Netto, Roberta S. Stilhano, Ariadiny L. Caetano
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Tonic noradrenergic input to neurons in the dorsal raphe nucleus mediates food intake in male mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-23 Rafael Appel Flores, Raoni C. Dos-Santos, Isabelle Rodrigues-Santos, Aline Alves de Jesus, José Antunes-Rodrigues, Lucila L.K. Elias
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CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-22 Kunyu Wang, Yu Yang, Yiwen Wang, Zhuoya Jiang, Shaokuan Fang
Major depressive disorder (MDD) is a severe psychiatric disorder with uncertain causes. Recent studies have indicated correlations between circular RNAs (circRNAs) and psychiatric disorders. However, the potential role of circRNAs in MDD remains largely unknown. We investigated the expression and diagnostic significance of circRNA protein tyrosine kinase 2 (circPTK2) by recruiting 50 MDD patients and
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Acupuncture activates IRE1/XBP1 endoplasmic reticulum stress pathway in Parkinson's disease model rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-22 Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Ning
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Some key parameters in contextual fear conditioning and extinction in adult rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-01-22 Mónica Navarro-Sánchez, Isis Gil-Miravet, Daniel Montero-Caballero, Esther Castillo-Gómez, Andrew L. Gundlach, Francisco E. Olucha-Bordonau