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The DST gene in neurobiology J. Neurogenet. (IF 1.9) Pub Date : 2024-03-11 Robert Lalonde, Catherine Strazielle
DST is a gene whose alternative splicing yields epithelial, neuronal, and muscular isoforms. The autosomal recessive Dstdt (dystonia musculorum) spontaneous mouse mutation causes degeneration of sp...
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Genetic heterogeneity within a consanguineous family involving TTPA and SETX genes J. Neurogenet. (IF 1.9) Pub Date : 2023-12-18 Cyrine Jeridi, Amine Rachdi, Fatma Nabli, Zacharia Saied, Rania Zouari, Dina Ben Mohamed, Mariem Ben Said, Saber Masmoudi, Samia Ben Sassi, Rim Amouri
Autosomal recessive cerebellar ataxias (ARCA) constitute a highly heterogeneous group of progressive neurodegenerative disorders that typically occur prior to adulthood. Despite some clinical resem...
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Yin Yang 1 suppresses apoptosis and oxidative stress injury in SH-SY5Y cells by facilitating NR4A1 expression J. Neurogenet. (IF 1.9) Pub Date : 2023-11-03 Qin Kang, Wen Chai, Jun Min, Xinhui Qu
Oxidative stress plays a significant role in the development of Parkinson’s disease (PD). Previous studies implicate nuclear receptor subfamily 4 group A member 1 (NR4A1) in oxidative stress associ...
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Neural stem cell-derived exosomal FTO protects neuron from microglial inflammatory injury by inhibiting microglia NRF2 mRNA m6A modification J. Neurogenet. (IF 1.9) Pub Date : 2023-10-16 Zhiyong Li, Zhenggang Chen, Jun Peng
Ischemic stroke (IS) can cause neuronal cell loss and function defects. Exosomes derived from neural stem cells (NSC-Exos) improve neural plasticity and promote neural function repair following IS....
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Editorial/preface: Neurogenetics innovation in South Korea J. Neurogenet. (IF 1.9) Pub Date : 2023-06-12 Jing W. Wang, Greg S. B. Suh, Chun-Fang Wu
Published in Journal of Neurogenetics (Vol. 37, No. 1-2, 2023)
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Starvation-induced sleep suppression requires the Drosophila brain nutrient sensor J. Neurogenet. (IF 1.9) Pub Date : 2023-06-02 Yangkyun Oh, Greg S. B. Suh
Abstract Animals increase their locomotion activity and reduce sleep duration under starved conditions. This suggests that sleep and metabolic status are closely interconnected. The nutrient and hunger sensors in the Drosophila brain, including diuretic hormone 44 (DH44)–, CN–, and cupcake-expressing neurons, detect circulating glucose levels in the internal milieu, regulate the insulin and glucagon
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A deep learning analysis of Drosophila body kinematics during magnetically tethered flight J. Neurogenet. (IF 1.9) Pub Date : 2023-05-18 Geonil Kim, JoonHu An, Subin Ha, Anmo J. Kim
Abstract Flying Drosophila rely on their vision to detect visual objects and adjust their flight course. Despite their robust fixation on a dark, vertical bar, our understanding of the underlying visuomotor neural circuits remains limited, in part due to difficulties in analyzing detailed body kinematics in a sensitive behavioral assay. In this study, we observed the body kinematics of flying Drosophila
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Knockdown of circ_CLIP2 regulates the proliferation, metastasis and apoptosis of glioma cells through miR-641/EPHA3/STAT3 axis J. Neurogenet. (IF 1.9) Pub Date : 2023-04-27 Huibing Li, Xin Jin, Mingyao Lai, Yongshi Li, Ruixing Li, Huihui Yang, Baoying Yang
A great amount of reaches have confirmed that circular RNAs (circRNAs) are novel regulators in glioma progression. Here, our work aimed to probe the specific role of circ_CLIP2 in glioma. The mRNA ...
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A conserved function of Pkhd1l1, a mammalian hair cell stereociliary coat protein, in regulating hearing in zebrafish J. Neurogenet. (IF 1.9) Pub Date : 2023-03-24 Stylianos Makrogkikas, Ruey-Kuang Cheng, Hao Lu, Sudipto Roy
Pkhd1l1 is predicted to encode a very large type-I transmembrane protein, but its function has largely remained obscure. Recently, it was shown that Pkhdl1l1 is a component of the coat that decorat...
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Evaluation of mouse behavioral responses to nutritive versus nonnutritive sugar using a deep learning-based 3D real-time pose estimation system J. Neurogenet. (IF 1.9) Pub Date : 2023-02-15 Jineun Kim, Dae-gun Kim, Wongyo Jung, Greg S. B. Suh
Abstract Animals are able to detect the nutritional content of sugar independently of taste. When given a choice between nutritive sugar and nonnutritive sugar, animals develop a preference for nutritive sugar over nonnutritive sugar during a period of food deprivation (Buchanan et al., 2022 Buchanan, K. L., Rupprecht, L. E., Kaelberer, M. M., Sahasrabudhe, A., Klein, M. E., Villalobos, J. A., Liu
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An expansion of phenotype: novel homozygous variant in the MED17 identified in patients with progressive microcephaly and global developmental delay J. Neurogenet. (IF 1.9) Pub Date : 2022-12-12 Rafiullah Rafiullah, Alia M. Albalawi, Sultan R. Alaradi, Majed Alluqmani, Muhammad Mushtaq, Abdul Wali, Sulman Basit
Abstract Global developmental delay (GDD) is a lifelong disability that affects 1–3% of the population around the globe. It is phenotypically variable and highly heterogeneous in terms of the underlying genetics. Patients with GDD are intellectually disabled (ID) manifesting cognitive impairment and deficient adaptive behavior. Here, we investigated a two-looped consanguineous family segregating severe
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Circadian gating of light-induced arousal in Drosophila sleep J. Neurogenet. (IF 1.9) Pub Date : 2022-12-01 Hoyeon Lee, Chunghun Lim
Abstract Circadian rhythms and sleep homeostasis constitute the two-process model for daily sleep regulation. However, evidence for circadian control of sleep-wake cycles has been relatively short since clock-less animals often show sleep behaviors quantitatively comparable to wild-type. Here we examine Drosophila sleep behaviors under different light-dark regimes and demonstrate that circadian clocks
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Knockdown of glutathione S-transferase leads to mislocalization and accumulation of cabeza, a drosophila homolog of FUS, in the brain J. Neurogenet. (IF 1.9) Pub Date : 2022-11-27 Sun Joo Cha, Ja Hoon Yoon, Yeo Jeong Han, Kiyoung Kim
Abstract Glutathione S-transferase omega (GSTO) is an antioxidant enzyme involved in reducing oxidative stress. Recent studies suggest that polymorphic variants of GSTOs affect the onset age and progression of neurodegenerative diseases. Although GSTO activity may affect the development and age dependency of several diseases, the mechanism by which GSTO inactivation in neurons regulates the susceptibility
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Possible association between the lrrk2 gene and anxiety behavior: a systematic literature review J. Neurogenet. (IF 1.9) Pub Date : 2022-11-22 RE Moreira-Júnior, RM Souza, JG de Carvalho, JP Bergamini, AL Brunialti-Godard
Abstract Alterations to the LRRK2 gene have been associated with Parkinson’s disease and alcohol consumption in animals and humans. Furthermore, these disorders are strongly related to anxiety disorders (ADs). Thus, we investigated how the LRRK2 gene might influence anxiety in humans and mice. We elaborated a systematic review based on the PRISMA Statement of studies that investigated levels of anxiety
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Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila J. Neurogenet. (IF 1.9) Pub Date : 2022-11-22 Mari Kim, Gwang-Ic Son, Yun-Ho Cho, Gye-Hyeong Kim, Sung-Eun Yoon, Young-Joon Kim, Jongkyeong Chung, Eunil Lee, Joong-Jean Park
Abstract The rhythmic pattern of biological processes controlled by light over 24 h is termed the circadian rhythm. Disturbance of circadian rhythm due to exposure to light at night (LAN) disrupts the sleep-wake cycle and can promote cardiovascular disease, diabetes, cancer, and metabolic disorders in humans. We studied how dim LAN affects the circadian rhythm and metabolism using male Drosophila.
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Inter-organ regulation by the brain in Drosophila development and physiology J. Neurogenet. (IF 1.9) Pub Date : 2022-11-12 Sunggyu Yoon, Mingyu Shin, Jiwon Shim
Abstract The brain plays an essential role in regulating physiological homeostasis by communicating with other organs. Neuronal cells either directly innervate target tissues and transmit signals or secrete systemic factors into the hemolymph to regulate bodily functions, including physiology, development, metabolism, and immunity. In this review, we discuss the systemic functions of inter-organ communication
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The origins of the force-from-lipid principle and the founding member of the TRP channel superfamily J. Neurogenet. (IF 1.9) Pub Date : 2022-10-13 Chun-Fang Wu
Published in Journal of Neurogenetics (Vol. 36, No. 2-3, 2022)
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Abnormalities of neural stem cells in Lesch–Nyhan disease J. Neurogenet. (IF 1.9) Pub Date : 2022-10-13 Ashok R. Dinasarapu, Diane J. Sutcliffe, Fatemeh Seifar, Jasper E. Visser, H. A. Jinnah
Abstract Lesch–Nyhan disease (LND) is a neurodevelopmental disorder caused by variants in the HPRT1 gene, which encodes the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGprt). HGprt deficiency provokes numerous metabolic changes which vary among different cell types, making it unclear which changes are most relevant for abnormal neural development. To begin to elucidate the consequences
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The light-activated TRP channel: the founding member of the TRP channel superfamily J. Neurogenet. (IF 1.9) Pub Date : 2022-10-10 Baruch Minke, William L. Pak
Abstract The Drosophila light-activated Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. The Drosophila TRP (dTRP) channel, which generates the electrical response to light has been investigated in a great detail two decades before the first mammalian TRP channel was discovered. Thus, dTRP is unique among members of the TRP channel
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History of Drosophila neurogenetic research in South Korea J. Neurogenet. (IF 1.9) Pub Date : 2022-09-27 Greg S. B. Suh, Kweon Yu, Young-Joon Kim, Yangkyun Oh, Joong-Jean Park
Abstract Neurogenetic research using the Drosophila model has immensely expanded around the world. Likewise, scientists in South Korea have leveraged the advantages of Drosophila genetic tools to understand various neurobiological processes. In this special issue, we will overview the history of Drosophila neurogenetic research in South Korea that led to significant discoveries and notably implications
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PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403 J. Neurogenet. (IF 1.9) Pub Date : 2022-08-24 Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Kim
Abstract Tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as Alzheimer’s disease and other related tauopathies. A relationship between abnormal Tau accumulation and ubiquitin–proteasome system impairment has been reported. However, the molecular mechanism linking Tau accumulation and ubiquitin proteasome
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TERT distal promoter GC islands are critical for telomerase and together with DNMT3B silencing may serve as a senescence-inducing agent in gliomas J. Neurogenet. (IF 1.9) Pub Date : 2022-08-23 Naz Şerifoğlu, Begün Erbaba, Michelle M. Adams, Ayça Arslan-Ergül
Abstract Telomerase is reactivated in the majority of cancers. For instance, in gliomas, it is common that the TERT promoter is mutated. Research on telomere promoter GC islands have been focused primarily on proximal TERT promoter but little is known about the distal promoter. Therefore, in this study, we investigated the proximal and distal TERT promoter, in terms of DNA methylation. We did bisulfite
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Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway J. Neurogenet. (IF 1.9) Pub Date : 2022-07-27 Chengyong Guo, Shuo Liu, Tao Zhang, Jipeng Yang, Zhaohui Liang, Shengkui Lu
Abstract Pleckstrin homology like domain family A member 2 (PHLDA2) is an imprinted gene expressed in placenta and has been shown to be associated with tumor progression. However, the effect of PHLDA2 on glioma cell growth has not been reported yet. Data based on TCGA database showed that PHLDA2 was up-regulated in glioma tissues. Moreover, PHLDA2 was also elevated in glioma cells. Functional assays
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The force-from-lipid principle and its origin, a ‘what is true for E. coli is true for the elephant’ refrain J. Neurogenet. (IF 1.9) Pub Date : 2022-07-23 Boris Martinac, Ching Kung
Abstract The force-from-lipid (FFL) principle states that it is the lateral stretch force from the lipid membrane that ultimately opens mechanosensitive (MS) channels, not the external tether nor the internal cytoskeleton. Piezo channels for certain touch or proprioception and the hair-cell channels for hearing or balance apparently obey this principle, which is based on the idea that the lipid bilayer
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Abnormal larval neuromuscular junction morphology and physiology in Drosophila prickle isoform mutants with known axonal transport defects and adult seizure behavior J. Neurogenet. (IF 1.9) Pub Date : 2022-07-01 Atsushi Ueda, Tristan C. D. G. O’Harrow, Xiaomin Xing, Salleh Ehaideb, J. Robert Manak, Chun-Fang Wu
Abstract Previous studies have demonstrated the striking mutational effects of the Drosophila planar cell polarity gene prickle (pk) on larval motor axon microtubule-mediated vesicular transport and on adult epileptic behavior associated with neuronal circuit hyperexcitability. Mutant alleles of the prickle-prickle (pkpk) and prickle-spiny-legs (pksple) isoforms (hereafter referred to as pk and sple
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LncRNA GAS5 promotes epilepsy progression through the epigenetic repression of miR-219, in turn affecting CaMKIIγ/NMDAR pathway J. Neurogenet. (IF 1.9) Pub Date : 2022-06-01 Chen-Sheng Zhao, Dong-Xing Liu, Yan-Huai Fan, Jian-Kun Wu
Abstract It has been widely reported that dysregulated long-chain noncoding RNAs (lncRNAs) are closely associated with epilepsy. This study aimed to probe the function of lncRNA growth arrest-specific 5 (GAS5), microRNA (miR)-219 and Calmodulin-dependent protein kinase II (CaMKII)γ/N-methyl-D-aspartate receptor (NMDAR) pathway in epilepsy. Epileptic cell and animal models were constructed using magnesium
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Novel insights into the genetic profile of hereditary spastic paraplegia in India J. Neurogenet. (IF 1.9) Pub Date : 2022-05-02 Sundarapandian Narendiran, Monojit Debnath, Sumanth Shivaram, Ramakrishnan Kannan, Shivani Sharma, Rita Christopher, Doniparthi V. Seshagiri, Sanjeev Jain, Meera Purushottam, Sandhya Mangalore, Rose Dawn Bharath, Parayil Sankaran Bindu, Sanjib Sinha, Arun B. Taly, Madhu Nagappa
Abstract The Hereditary Spastic Paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by length dependent degeneration of the corticospinal tracts. Genetic data related to HSPs are limited from India. We aimed to comprehensively analyse the phenotypic characteristics and genetic basis of a large cohort of HSP from India. Patients with HSP phenotype were
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Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Drosophila model of Parkinson’s disease J. Neurogenet. (IF 1.9) Pub Date : 2022-04-25 Ilia M. Golomidov, Evgenia M. Latypova, Elena V. Ryabova, Olga I. Bolshakova, Artem E. Komissarov, Svetlana V. Sarantseva
Abstract Parkinson’s disease (PD) is a neurodegenerative disease characterised by the formation of Lewy bodies and progressive loss of dopaminergic (DA) neurons in the substantia nigra. Lewy bodies mainly consist of α-synuclein, which plays a critical role in the pathophysiology of PD. The α-synuclein is encoded by the SNCA gene and is the first identified gene associated with hereditary PD. Currently
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lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer’s disease J. Neurogenet. (IF 1.9) Pub Date : 2022-01-31 Xi-Wu Yan, Huai-Jun Liu, Yu-Xing Hong, Ting Meng, Jun Du, Cheng Chang
Abstract Alzheimer’s disease (AD) is the leading cause of dementia globally, but effective treatment is lacking. We aimed to explore lncRNA XIST role in AD and the mechanisms involved in the effect of changes in lncRNA XIST on the expression of Aβ-degrading enzymes. The mouse model of AD and the cell model induced by Aβ were established. LncRNA XIST, IDE, NEP, Plasmin, ACE, EZH2 expressions and distribution
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Spatiotemporal organization of enteroendocrine peptide expression in Drosophila J. Neurogenet. (IF 1.9) Pub Date : 2021-10-20 Sooin Jang, Ji Chen, Jaekyun Choi, Seung Yeon Lim, Hyejin Song, Hyungjun Choi, Hyung Wook Kwon, Min Sung Choi, Jae Young Kwon
Abstract The digestion of food and absorption of nutrients occurs in the gut. The nutritional value of food and its nutrients is detected by enteroendocrine cells, and peptide hormones produced by the enteroendocrine cells are thought to be involved in metabolic homeostasis, but the specific mechanisms are still elusive. The enteroendocrine cells are scattered over the entire gastrointestinal tract
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Transcending boundaries: from quantitative genetics to single genes J. Neurogenet. (IF 1.9) Pub Date : 2021-09-20 Jeffrey S. Dason, Ina Anreiter, Chun-Fang Wu
(2021). Transcending boundaries: from quantitative genetics to single genes. Journal of Neurogenetics: Vol. 35, Transcending boundaries: from quantitative genetics to single genes. Guest Editors: Jeffrey S. Dason and Ina Anreiter, pp. 95-98.
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Marla Sokolowski: and now for someone completely different J. Neurogenet. (IF 1.9) Pub Date : 2021-07-14 H. Sofia Pereira, Karen D. Williams, J. Steven de Belle
Abstract A comprehensive science, technology, engineering, and mathematics (STEM) education has persistent formative effects on individuals, communities, and society. In this regard, Marla Sokolowski’s academic legacy will forever reflect her unique contributions to STEM education and mentoring. Furthermore, her creative and multidisciplinary approach to research has resulted in groundbreaking advances
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Expression of the foraging gene in adult Drosophila melanogaster J. Neurogenet. (IF 1.9) Pub Date : 2021-08-12 Aaron M. Allen, Marla B. Sokolowski
Abstract The foraging gene in Drosophila melanogaster, which encodes a cGMP-dependent protein kinase, is a highly conserved, complex gene with multiple pleiotropic behavioral and physiological functions in both the larval and adult fly. Adult foraging expression is less well characterized than in the larva. We characterized foraging expression in the brain, gastric system, and reproductive systems
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Characterization of a novel stimulus-induced glial calcium wave in Drosophila larval peripheral segmental nerves and its role in PKG-modulated thermoprotection J. Neurogenet. (IF 1.9) Pub Date : 2021-07-26 Jennifer L. Krill, Ken Dawson-Scully
Abstract Insects, as poikilotherms, have adaptations to deal with wide ranges in temperature fluctuation. Allelic variations in the foraging gene that encodes a cGMP dependent protein kinase, were discovered to have effects on behavior in Drosophila by Dr. Marla Sokolowski in 1980. This single gene has many pleiotropic effects and influences feeding behavior, metabolic storage, learning and memory
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Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster J. Neurogenet. (IF 1.9) Pub Date : 2021-07-14 Anders Vesterberg, Rudy Rizkalla, Mark J. Fitzpatrick
Abstract Deciding whether or not to lay an egg on a given substrate is an important task undertaken by females of many arthropods. It involves perceiving the environment (e.g. quality of the substrate, temperature, and humidity), formulating a decision, and then conducting the appropriate behaviours to oviposit. This oviposition site selection (OSS) provides a useful system for studying simple decision-making
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Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster J. Neurogenet. (IF 1.9) Pub Date : 2021-08-02 Megan C. Neville, Alexander Eastwood, Aaron M. Allen, Ammerins de Haan, Tetsuya Nojima, Stephen F. Goodwin
Abstract The identification of mutations in the gene fruitless (fru) paved the way for understanding the genetic basis of male sexual behavior in the vinegar fly Drosophila melanogaster. D. melanogaster males perform an elaborate courtship display to the female, ultimately leading to copulation. Mutations in fru have been shown to disrupt most aspects of the male's behavioral display, rendering males
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Fly seizure EEG: field potential activity in the Drosophila brain J. Neurogenet. (IF 1.9) Pub Date : 2021-07-18 Atulya Iyengar, Chun-Fang Wu
Abstract Hypersynchronous neural activity is a characteristic feature of seizures. Although many Drosophila mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local field
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Forty years of foraging research: a legacy of scientists trained and influenced by Marla Sokolowski J. Neurogenet. (IF 1.9) Pub Date : 2021-09-20 Ina Anreiter, Jeffrey S. Dason
(2021). Forty years of foraging research: a legacy of scientists trained and influenced by Marla Sokolowski. Journal of Neurogenetics: Vol. 35, Transcending boundaries: from quantitative genetics to single genes. Guest Editors: Jeffrey S. Dason and Ina Anreiter, pp. 341-350.
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Does oxidatively damaged DNA drive amyloid-β generation in Alzheimer’s disease? A hypothesis J. Neurogenet. (IF 1.9) Pub Date : 2021-07-20 Owen Davis Sanders, Lekshmy Rajagopal, Jayalekshmi Archa Rajagopal
Abstract In Alzheimer’s disease (AD), amyloid-β (Aβ) generation and upstream β-secretase 1 (BACE1) expression appear to be driven by oxidative stress via c-Jun N-terminal kinase (JNK), p38, and Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (PKR). In addition, inflammatory molecules, including lipopolysaccharide (LPS), induce genes central to Aβ genesis, such as BACE1, via nuclear
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Molecular spectrum, family screening and genetic counselling of Spinocerebellar Ataxia (SCA) cases in an Indian scenario J. Neurogenet. (IF 1.9) Pub Date : 2021-06-23 Priyanka Vishwakarma, Sarita Agarwal, Deepika Delsa Dean, Srinivasan Muthuswamy, Kausik Mandal
Abstract Spinocerebellar Ataxia (SCA) is a heterogeneous adult-onset disorder with an autosomal dominant inheritance pattern mainly caused by triplet repeat expansions. Clinical diagnosis of SCA is based on phenotypic features followed by confirmation through molecular diagnosis. To identify status of repeat range in Indian SCA cases and provide extended family screening, we enrolled 70 clinical SCA
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Travels with Curly: A personal, collegial tribute to Professor Marla Sokolowski J. Neurogenet. (IF 1.9) Pub Date : 2021-06-22 W. Thomas Boyce
Abstract Marla Sokolowski's work and humanity has influenced the careers of hundreds, perhaps thousands, of younger scientists. Her fundamental research on the neurogenetic underpinnings of behavior in Drosophila melanogaster is remarkable not only for its scientific brilliance, but for the humility, care, and humor with which it was conducted.
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The long view: a spouse’s perspective J. Neurogenet. (IF 1.9) Pub Date : 2021-06-21 Allen B. Sokolowski
(2021). The long view: a spouse’s perspective. Journal of Neurogenetics: Vol. 35, Transcending boundaries: from quantitative genetics to single genes. Guest Editors: Jeffrey S. Dason and Ina Anreiter, pp. 99-100.
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Marla Sokolowski Retrospectively J. Neurogenet. (IF 1.9) Pub Date : 2021-06-21 Harold L. Atwood
Abstract Marla Sokolowski’s scientific achievements established her as an internationally recognized leader in behavioural genetics. As a graduate student, she made a significant discovery while observing natural populations of the fruit fly, Drosophila melanogaster: the larvae exhibited a behavioural polymorphism which she traced to alleles of a single gene. Some larvae were ‘sitters’ which fed in
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The foraging gene as a modulator of division of labour in social insects J. Neurogenet. (IF 1.9) Pub Date : 2021-06-20 Christophe Lucas, Yehuda Ben-Shahar
Abstract The social ants, bees, wasps, and termites include some of the most ecologically-successful groups of animal species. Their dominance in most terrestrial environments is attributed to their social lifestyle, which enable their colonies to exploit environmental resources with remarkable efficiency. One key attribute of social insect colonies is the division of labour that emerges among the
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Women in science: a daughter’s perspective J. Neurogenet. (IF 1.9) Pub Date : 2021-06-20 H. Moriah Sokolowski
Abstract In the first grade, in one of my first classes, my teacher read us a story about a scientist. To my utter shock, the scientist was a man. After the story, I asked the teacher, ‘can men be scientists?’ She looked at me, bewildered, and replied: ‘of course, anyone can be a scientist.’ It was not until later that my teacher learned that my mother is a scientist, and the only scientists I had
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Gaining an understanding of behavioral genetics through studies of foraging in Drosophila and learning in C. elegans J. Neurogenet. (IF 1.9) Pub Date : 2021-06-20 Aaron P. Reiss, Catharine H. Rankin
Abstract The pursuit of understanding behavior has led to investigations of how genes, the environment, and the nervous system all work together to produce and influence behavior, giving rise to a field of research known as behavioral neurogenetics. This review focuses on the research journeys of two pioneers of aspects of behavioral neurogenetic research: Dr. Marla Sokolowski and Dr. Catharine Rankin
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Learning about quantitative genetics from Marla Sokolowski J. Neurogenet. (IF 1.9) Pub Date : 2021-06-15 Ralph J. Greenspan
Abstract Marla Sokolowski is a true pioneer in behavioral genetics, having made the first molecular delineation of a naturally occurring behavioral polymorphism in her work on the foraging locus in Drosophila melanogaster. The gene was subsequently found to be responsible for behavioral variants and types in many other species, both invertebrate and mammal (human). The path to get there is a paradigmatic
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Women in science: a son’s perspective J. Neurogenet. (IF 1.9) Pub Date : 2021-06-12 Dustin J. Sokolowski
Abstract I am often asked how our mother inspired my sister Moriah and me to want to become scientists. She never directly suggested we should go down that path. Instead, she shared the aspects of the natural world, that she loved, with us while keeping the non-science aspects of her job separate from our lives at home. Now, I have learned that her perspective provides insights that spark innovative
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The Drosophila melanogaster foraging gene affects social networks J. Neurogenet. (IF 1.9) Pub Date : 2021-06-12 Nawar Alwash, Aaron M. Allen, Marla B. Sokolowski, Joel D. Levine
Abstract Drosophila melanogaster displays social behaviors including courtship, mating, aggression, and group foraging. Recent studies employed social network analyses (SNAs) to show that D. melanogaster strains differ in their group behavior, suggesting that genes influence social network phenotypes. Aside from genes associated with sensory function, few studies address the genetic underpinnings of
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Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer’s disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles J. Neurogenet. (IF 1.9) Pub Date : 2021-05-10 David Curtis, Alzheimer's Disease Neuroimaging Initiative
Abstract Variants in APOE are associated with risk of late onset Alzheimer's disease (LOAD) but the magnitude of the effect has been reported to vary across ancestries. Also, other variants in the region have been reported to show association though it has been unclear whether this was secondary to their linkage disequilibrium with the APOE variants rs429358 and rs7412. Previous analyses of exome-sequenced
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De novo mutation in SLC25A22 gene: expansion of the clinical and electroencephalographic phenotype J. Neurogenet. (IF 1.9) Pub Date : 2021-04-06 Antonio Gennaro Nicotera, Daniela Dicanio, Erica Pironti, Maria Bonsignore, Anna Cafeo, Stephanie Efthymiou, Patrizia Mondello, Vincenzo Salpietro, Henry Houlden, Gabriella Di Rosa
Abstract The SLC25A22 (Solute Carrier Family 25, Member 22) gene encodes for a mitochondrial glutamate/H+ symporter and is involved in the mitochondrial transport of metabolites across the mitochondrial membrane. We hereby report a 12-year-old girl presenting with early-onset epileptic encephalopathy, hypotonia, and global developmental delay. Whole exome sequencing identified a novel homozygous missense
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Compound heterozygous KCTD7 variants in progressive myoclonus epilepsy J. Neurogenet. (IF 1.9) Pub Date : 2021-05-10 Elizabeth A. Burke, Morgan Sturgeon, Diane B. Zastrow, Liliana Fernandez, Cameron Prybol, Shruti Marwaha, Edward P. Frothingham, Patricia A. Ward, Christine M. Eng, Laure Fresard, Stephen B. Montgomery, Gregory M. Enns, Paul G. Fisher, Lynne A. Wolfe, Brian Harding, Blake Carrington, Kevin Bishop, Raman Sood, Yan Huang, Abdel Elkahloun, Camilo Toro, Alexander G. Bassuk, Matthew T. Wheeler, Thomas C
Abstract KCTD7 is a member of the potassium channel tetramerization domain-containing protein family and has been associated with progressive myoclonic epilepsy (PME), characterized by myoclonus, epilepsy, and neurological deterioration. Here we report four affected individuals from two unrelated families in which we identified KCTD7 compound heterozygous single nucleotide variants through exome sequencing
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A latitudinal cline in a courtship song character of Drosophila melanogaster J. Neurogenet. (IF 1.9) Pub Date : 2021-06-08 Rosamund A. Stanley, Charalambos P. Kyriacou
Abstract The courtship song of male Drosophila melanogaster is generated by wing vibration and contains an interpulse interval (IPI) which is species-specific and usually falls in the mean range of 30–40 ms. The IPI is extremely temperature-sensitive, so we wondered whether flies collected along the eastern coast of Australia between latitudes 16.9°S and 42.9°S might have adapted to the different thermal
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Loss of mGluR1-LTD following cocaine exposure accumulates Ca2+-permeable AMPA receptors and facilitates synaptic potentiation in the prefrontal cortex J. Neurogenet. (IF 1.9) Pub Date : 2021-06-07 Hongyu Ruan, Wei-Dong Yao
Abstract Addiction results from drug-elicited alterations of synaptic plasticity mechanisms in dopaminergic reward circuits. Impaired metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) and accumulation of synaptic Ca2+-permeable AMPA receptors (CP-AMPARs) following drug exposure have emerged as important mechanisms underlying drug craving and relapse. Here we show that repeated
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The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila J. Neurogenet. (IF 1.9) Pub Date : 2021-06-07 Anne S. Oepen, Jamie L. Catalano, Reza Azanchi, Karla R. Kaun
Abstract The genetic basis of alcohol use disorder (AUD) is complex. Understanding how natural genetic variation contributes to alcohol phenotypes can help us identify and understand the genetic basis of AUD. Recently, a single nucleotide polymorphism in the human foraging (for) gene ortholog, Protein Kinase cGMP-Dependent 1 (PRKG1), was found to be associated with stress-induced risk for alcohol abuse
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Dysregulation of Myt1 expression acts as a potential peripheral biomarker for major depressive disorder and bipolar disorder J. Neurogenet. (IF 1.9) Pub Date : 2021-05-20 Maryam Ghanbarirad, Mehrdad Hashemi, Seyed Mehdi Saberi, Ahmad Majd
Abstract Major depressive disorder (MDD) and bipolar disorder (BPD) are among the most debilitating mental conditions. Diagnostic criteria for MDD include psychological and physical symptoms, such as low mood and changes in appetite or sleep, respectively. BPD in addition to periods of depression represents episodes of mania or hypomania, and elevation in mood and energy levels are associated with
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A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function J. Neurogenet. (IF 1.9) Pub Date : 2021-05-16 Jeffrey S. Dason, Marla B. Sokolowski
Abstract A cGMP-dependent protein kinase (PKG) encoded by the Drosophila foraging (for) gene regulates both synaptic structure (nerve terminal growth) and function (neurotransmission) through independent mechanisms at the Drosophila larval neuromuscular junction (nmj). Glial for is known to restrict nerve terminal growth, whereas presynaptic for inhibits synaptic vesicle (SV) exocytosis during low
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Change in gene expression levels of GABA, glutamate and neurosteroid pathways due to acoustic trauma in the cochlea J. Neurogenet. (IF 1.9) Pub Date : 2021-04-07 Meltem Cerrah Gunes, Murat Salih Gunes, Alperen Vural, Fatma Aybuga, Arslan Bayram, Keziban Korkmaz Bayram, Mehmet Ilhan Sahin, Muhammet Ensar Dogan, Sevda Yesim Ozdemir, Yusuf Ozkul
Abstract The characteristic feature of noise-induced hearing loss (NIHL) is the loss or malfunction of the outer hair cells (OHC) and the inner hair cells (IHC) of the cochlea. 90–95% of the spiral ganglion neurons, forming the cell bodies of cochlear nerve, synapse with the IHCs. Glutamate is the most potent excitatory neurotransmitter for IHC-auditory nerve synapses. Excessive release of glutamate
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The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence J. Neurogenet. (IF 1.9) Pub Date : 2021-05-04 Ina Anreiter, Aaron M. Allen, Oscar E. Vasquez, Lydia To, Scott J. Douglas, Javier V. Alvarez, John Ewer, Marla B. Sokolowski
Abstract The foraging (for) gene has been extensively studied in many species for its functions in development, physiology, and behavior. It is common for genes that influence behavior and development to be essential genes, and for has been found to be an essential gene in both fruit flies and mammals, with for mutants dying before reaching the adult stage. However, the biological process underlying
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She’s got nerve: roles of octopamine in insect female reproduction J. Neurogenet. (IF 1.9) Pub Date : 2021-04-28 Melissa A. White, Dawn S. Chen, Mariana F. Wolfner
Abstract The biogenic monoamine octopamine (OA) is a crucial regulator of invertebrate physiology and behavior. Since its discovery in the 1950s in octopus salivary glands, OA has been implicated in many biological processes among diverse invertebrate lineages. It can act as a neurotransmitter, neuromodulator and neurohormone in a variety of biological contexts, and can mediate processes including