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Corrigendum to “RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells” [Brain Res. Bull. 146 (2019) 228–236] Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-14 Xiao-Ling Zhang, Zhen-Zhen Wang, Qian-Hang Shao, Zhao Zhang, Lin Li, Zhen-Yu Guo, Hong-Mei Sun, Yi Zhang, Nai-Hong Chen
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Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-12 Han Shi, Yan Zhang, YongFeng Yang, HaiSan Zhang, WenQiang Li, ZhaoXi Zhong, LuXian Lv
Schizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine
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The Role of Attention in Immersion: The Two–Competitor Model Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-08 Daniel J. Strauss, Alexander L. Francis, Jonas Vibell, Farah I Corona–Strauss
Currently, we face an exponentially increasing interest in immersion, espe- cially sensory–driven immersion, mainly due to the rapid development of ideas and business models centered around a digital virtual universe as well as the increasing availability of affordable immersive technologies for education, com- munication, and entertainment. However, a clear definition of ’immersion’, in terms of established
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Mechanisms and protective measures for radiation-induced brachial plexus nerve injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-07 Jia ying Wei, Li xin Ma, Wen tong Liu, Li hua Dong, Xue Hou, Xue ying Bao, Wei Hou
Radiation therapy is a common treatment modality for patients with malignant tumors of the head and neck, chest and axilla. However, radiotherapy inevitably causes damage to normal tissues at the irradiated site, among which damage to the brachial plexus nerve(BP) is a serious adverse effect in patients receiving radiation therapy in the scapular or axillary regions, with clinical manifestations including
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Targeting blood-brain barrier for sepsis-associated encephalopathy: Regulation of immune cells and ncRNAs Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-06 Mi Tian, Yunliang Zhan, Jinyuan Cao, Jinqi Gao, Jie Sun, Li Zhang
Sepsis causes significant morbidity and mortality worldwide, most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). SAE involves many pathological processes, including the blood-brain barrier (BBB) damage. The BBB is located at the interface between the central nervous system and the surrounding environment, which protects the central
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Global research evolution and frontier analysis of artificial intelligence in brain injury: A bibliometric analysis Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-05 Mengqi Qu, Yang Xu, Lu Lu
Research on artificial intelligence for brain injury is currently a prominent area of scientific research. A significant amount of related literature has been accumulated in this field. This study aims to identify hotspots and clarify research resources by conducting literature metrology visualization analysis, providing valuable ideas and references for related fields. The research object of this
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Tunneling nanotubes: The transport highway for astrocyte-neuron communication in the central nervous system Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-05 Cuixiang Zhou, Min Huang, Shasha Wang, Shifeng Chu, Zhao Zhang, Naihong Chen
Tunneling nanotubes (TNTs) have emerged as pivotal structures for intercellular communication, enabling the transfer of cellular components across distant cells. Their involvement in neurological disorders has attracted considerable scientific interest. This review delineates the functions of TNTs within the central nervous system, examining their role in the transmission of bioenergetic substrates
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Rosiglitazone regulates astrocyte polarization and neuroinflammation in a PPAR-γ dependent manner after experimental traumatic brain injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-02 Xu Ren, Yun-Fei Li, Tian-Wei Pei, Hao-Sheng Wang, Yu-Hai Wang, Tao Chen
Traumatic brain injury (TBI) is a leading cause of high mortality and disability worldwide. Overactivation of astrocytes and overexpression of inflammatory responses in the injured brain are characteristic pathological features of TBI. Rosiglitazone (ROS) is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist known for its anti-inflammatory activity. However, the relationship between the
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Functional interaction of abnormal beta and gamma oscillations on bradykinesia in parkinsonian rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-02 Xinxin Jiang, Jian Yang, Zirui Wang, Jun Jia, Gang Wang
Bradykinesia, a debilitating symptom characterized by impaired movement initiation and reduced speed in Parkinson’s disease (PD), is associated with abnormal oscillatory activity in the motor cortex-basal ganglia circuit. We investigated the interplay between abnormal beta and gamma oscillations in relation to bradykinesia in parkinsonian rats. Our findings showed reduced movement activities in parkinsonian
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The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-29 Ayman Alzu'bi, Worood Bani Baker, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Manal Isam AbuAlArjah, Ejlal Abu-El-Rub, Lena Tahat, Ahmed MNZ Helaly, Doaa S. Ghorab, Waseem El-Huneidi, Raed M. Al-Zoubi
Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model. Adult
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Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-28 Qian Zhang, Peilin Cong, Li Tian, Tingmei Wu, Xinwei Huang, Yuxin Zhang, Huanghui Wu, Huazheng Liang, Lize Xiong
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) is known to increase the risk of developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits in middle-aged mice (12-month-old), whether exercise can attenuate Hcy-induced hippocampus-related cognitive deficits
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The role of neuroglial cells communication in ischemic stroke Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-27 Yunling Yu, Xinglan Liao, Xinyu Xie, Qihua Li, Xuehong Chen, Ruizhen Liu
Ischemic stroke is one of the leading causes of death and disability globally, but its treatment options are limited due to therapeutic window and reperfusion injury constraints. Microglia, astrocytes, and oligodendrocytes are the major components of the neurovascular unit, and there is substantial evidence suggesting their contributions to maintaining homeostasis in the central nervous system. Neuroglial
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Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-27 Yu Han, Xinya Shen, Zhenkun Gao, Pingping Han, Xia Bi
Microglia activation and oligodendrocyte maturation are critical for remyelination after cerebral ischemia. Studies have shown that enriched environment (EE) can effectively alleviate stroke-induced neurological deficits. However, little is known about the mechanism associated with glial cells underlying the neuroprotection of EE. Therefore, this study focuses on investigating the effect of EE on activated
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NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at “Zusanli” (ST36)-induced analgesia in ankle arthritis rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-23 Jing-Wen Xu, Si-Qi Tang, Jie Lin, Yu-Jia Li, Dan Shen, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang
The efficacy of acupuncture at Zusanli (ST36) in alleviating lower-limb pain is widely acknowledged in clinical practice, while its underlying mechanism remains incompletely elucidated. Our previous research had revealed that the prompt analgesia induced by needling-ST36 was accompanied by expression alterations in certain exco-nucleotidases within the sciatic nerve. Building upon this finding, the
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Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-23 Bingzheng Gong, Mian Li, Ziru Wang, Gulingyue Hao, Liang Sun, Jingjun Zhang, Liangjie Yuan
medial temporal lobe epilepsy (mTLE) is among the most common types of temporal lobe epilepsy (TLE) ,it is generally resistant to drug treatment, which significantly impacts the quality of life and treatment. Research on novel therapeutic approaches for mTLE has become a current focus. Our study aims to construct and analyze a competing endogenous RNA (ceRNA) network that targets neuroinflammation
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Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-22 Fangyuan Zhou, Longwei Wei, Yinhao Wang, Wei Chen
To investigate the role of the striatal extracellular signal-regulated kinase (Erk1/2) and its phosphorylation (p-Erk1/2) in aerobic training to alleviate the development of the L-DOPA induced dyskinesia (LID) in PD mice. Forty-eight male C57BL/6 N mice were randomly divided into the 6-OHDA surgery group (6-OHDA, n=42) and the sham surgery group (Sham, n=6). A two-point injection of 6-OHDA into the
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The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-21 Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Vida Hojjati, Faezeh Ghorbani-Taherdehi, Amirhossein Sahebkar, Mahmoud Gorji-Valokola
Multiple sclerosis (MS) is considered an immune-mediated inflammatory disorder that causes cognitive impairments by damaging the hippocampal tissue. Conversely, norepinephrine (NEP) has anti-inflammatory and re-myelinating properties, which improve cognitive impairments. The aim of this study was to assess the neuroprotective effects of NEP on learning and memory disorders in an experimental animal
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The Role of T-lymphocytes in Central Nervous System Diseases Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-20 Jianing Shen, Ning Bian, Lu Zhao, Jingkuan Wei
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Functional connectivity alterations in PTSD patients with suicidal ideation Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-19 Stephen Wood, Samuel Booth, Ji Hyun Ko
Post-traumatic stress disorder (PTSD) is a highly prevalent psychological disorder characterized by intense feelings of fear or helplessness after experiencing a traumatic event. PTSD is highly comorbid with mood disorders and patients are at increased risk for suicide. The present study aimed to identify neural connectivity alterations associated with suicidal ideation (SI) in PTSD patients by using
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Electroencephalography oscillations can predict the cortical response following theta burst stimulation Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-16 Guiyuan Cai, Jiayue Xu, Qian Ding, Tuo Lin, Hongying Chen, Manfeng Wu, Wanqi Li, Gengbin Chen, Guangqing Xu, Yue Lan
Continuous theta burst stimulation and intermittent theta burst stimulation are clinically popular models of repetitive transcranial magnetic stimulation. However, they are limited by high variability between individuals in cortical excitability changes following stimulation. Although electroencephalography oscillations have been reported to modulate the cortical response to transcranial magnetic stimulation
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Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-15 Hyun Seung Shin, Seung Hyun Lee, Ha Jung Moon, Yun Hee So, Hyeon Jung Jang, Kyung-Ha Lee, Changhwan Ahn, Eui-Man Jung
Chronic stress is a pervasive and complex issue that contributes significantly to various mental and physical health disorders. Using the previously established chronic unpredictable stress (CUS) model, which simulates human stress situations, it has been shown that chronic stress induces major depressive disorder (MDD) and memory deficiency. However, this established model is associated with several
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Exploring resting-state EEG oscillations in patients with Neuromyelitis Optica Spectrum Disorder Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-15 Lili Yang, Congyu Xu, Yun Qin, Kai Chen, Yan Xie, Xiaobo Zhou, Tiejun Liu, Song Tan, Jie Liu, Dezhong Yao
Quantitative resting-state electroencephalography (rs-EEG) is a convenient method for characterizing the functional impairments and adaptations of the brain that has been shown to be valuable for assessing many neurological and psychiatric disorders, especially in monitoring disease status and assisting neuromodulation treatment. However, it has not yet been explored in patients with neuromyelitis
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Neonatal inhibition of androgen activity alters the programming of body weight and orexinergic peptides differentially in male and female rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-13 Beatriz Carrillo, Jose Manuel Fernandez-Garcia, Rocío García-Úbeda, Daniela Grassi, Ulises Primo, Noemí Blanco, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos
The involvement of androgens in the regulation of energy metabolism has been demonstrated. The main objective of the present research was to study the involvement of androgens in both the programming of energy metabolism and the regulatory peptides associated with feeding. For this purpose, androgen receptors and the main metabolic pathways of testosterone were inhibited during the first five days
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MGFKD: A semi-supervised multi-source domain adaptation algorithm for cross-subject EEG emotion recognition Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-12 Rui Zhang, Huifeng Guo, Zongxin Xu, Yuxia Hu, Mingming Chen, Lipeng Zhang
Currently, most models rarely consider the negative transfer problem in the research field of cross-subject EEG emotion recognition. To solve this problem, this paper proposes a semi-supervised domain adaptive algorithm based on few labeled samples of target subject, which called multi-domain geodesic flow kernel dynamic distribution alignment (MGFKD). It consists of three modules: 1) GFK common feature
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Topological alteration of the brain structural network in Parkinson’s disease with apathy Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-08 Shaoyun Ge, Jun Liu, Yongfeng Jia, Zihan Li, Jianwei Wang, Min Wang
Apathy is a common neuropsychiatric manifestations in Parkinson’s disease (PD), but neural network mechanisms still remain elusive. We aim to investigate the topological alteration of the brain structural network in PD with apathy. In the present study, a total of 47 apathetic PD (aPD) patients, 37 non-apathetic PD (naPD) patients, and 40 healthy controls (HCs) were enrolled. Diffusion tensor imaging
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Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral hypoperfusion rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-08 Bin Fan, Ying Zhang, Qihang Luo, Chizi Hao, Weijing Liao
A typical enriched environment (EE), which combines physical activity and social interaction, has been proven to mitigate cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, it remains unclear how the different components of EE promote cognitive recovery after CCH. This study stripped out the different components of EE into physical environmental enrichment (PE) and social
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Continuous inhalation of essential oil increases gray matter volume Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-07 Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa
Research into the health benefits of scents is on the rise. However, little is known about the effects of continuous inhalation, such as wearing scents on clothing, on brain structure. Therefore, in this study, an intervention study was conducted on a total of 50 healthy female people, 28 in the intervention group and 22 in the control group, asking them to wear a designated rose scent on their clothes
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Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-05 Hao Qian, Hui-Nan Zhang, Tian Gao, Xin-Shang Wang, Xing Wang, Man-Yang Yu, Ming-Kai Li, Jing Huang
Neutrophil infiltration has been linked to worse clinical outcomes after ischemic stroke. Microglia, a key type of immune-competent cell, engage in cross-talk with the infiltrating immune cells in the inflamed brain area, yet the molecular mechanisms involved remain largely unexplored. In this study, we investigated the mechanisms of how canonical transient receptor potential 1 (TRPC1) modulated neutrophil
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Statistical analysis and generative Artificial Intelligence (AI) for assessing pain experience, pain-induced disability, and quality of life in Parkinson's disease patients Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-04 Luana Conte, Roberto Lupo, Pierluigi Lezzi, Alessio Pedone, Ivan Rubbi, Alessia Lezzi, Elsa Vitale, Antonio Fasano, Giorgio De Nunzio
The Parkinson's Disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as tremors, rigidity, and bradykinesia, which can significantly impact various aspects of daily life. Among these aspects, pain is a prominent element. Despite the widespread use of therapies aimed at improving symptoms and quality of life, effective pain management is essential to enhance the
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IL-17A deficiency alleviates cerebral ischemia-reperfusion injury via activating ERK/MAPK pathway in hippocampal CA1 region Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-01 Yanan Li, Qi Zhang, Xupeng Wang, Fang Xu, Junfang Niu, Juan Zhao, Qiujun Wang
Cognitive impairment is a major complication of cerebral ischemia–reperfusion (CIR) injury and has an important impact on the quality of life of patients. However, the precise mechanisms underlying cognitive impairment after CIR injury remain elusive. In the current study, we investigated the role of interleukin 17 A (IL-17A) on CIR injury-induced cognitive impairment in wild-type and IL-17A knockout
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Hippocampal-prefrontal high-gamma flow during performance of a spatial working memory Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-26 Wenwen Bai, Yinglong Liu, Aili Liu, Xinyu Xu, Xuyuan Zheng, Xin Tian, Tiaotiao Liu
Working memory refers to a system that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. The prefrontal cortex (PFC) and hippocampus (HPC) are major structures contributing to working memory. Accumulating evidence suggests that the HPC-PFC interactions are critical for the successful execution of working memory tasks. Nevertheless, the directional
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Baicalein ameliorates cognitive impairment of vascular dementia rats via suppressing neuroinflammation and regulating intestinal microbiota Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-29 Jiaxi Song, Meixi Li, Ning Kang, Wei Jin, Yining Xiao, Zhe Li, Qianqian Qi, Jiayu Zhang, Yaxin Duan, Xiaoxiao Feng, Peiyuan Lv
Neuroinflammation induced by chronic cerebral hypoperfusion (CCH) plays a crucial role in the pathophysiologic mechanisms of vascular dementia (VD). A growing body of research has found that intestinal microbiota is associated with a variety of central nervous system disorders and that there is a relationship between intestinal microbiota dysbiosis and cognitive dysfunction and inflammatory responses
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Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-28 Chen-Xi Xu, Xin-Yi Qiu, Yi Guo, Tian-Ming Xu, Richard J. Traub, Hai-Nan Feng, Dong-Yuan Cao
Temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) may present as comorbid conditions, but treatment options are ineffective. The purpose of this study was to investigate whether valproate (VPA) attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress, which represents a model of pain associated with TMD and FMS comorbidity, and to explore the potential mechanisms
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Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1 Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Zhijuan Cheng, Jianglong Tu, Kai Wang, Fang Li, Yuan He, Wei Wu
Cerebral ischemia-reperfusion (IR) is the main pathophysiological process after stroke and can seriously impair neurological function. Wogonin, a natural flavonoid extracted from the roots of Scutellaria baicalensis, has potent anti-inflammatory properties. In this study, we investigated the protective mechanism of wogonin against middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation
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Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Kayla L. Nguyen, Ishaan J. Bhatt, Shruti Gupta, Nazaf Showkat, Kathryn A. Swanson, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Valerie Bracchi-Ricard, John R. Bethea
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes to inflammatory disease pathogenesis. In contrast, TNF receptor 2 signaling is neuroprotective. Current anti-TNF MS therapies are shown to be detrimental
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BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-19 Somaieh Matin, Masoomeh Dadkhah
Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor and cAMP response element-binding protein known as CREB/BDNF pathway plays have critical
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The seizure classification of focal epilepsy based on the network motif analysis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-17 Denggui Fan, Lixue Qi, Songan Hou, Qingyun Wang, Gerold Baier
Due to the complexity of focal epilepsy and its risk for transiting to the generalized epilepsy, the development of reliable classification methods to accurately predict and classify focal and generalized seizures is critical for the clinical management of patients with epilepsy. In order to holistically understand the seizure propagation behavior of focal epilepsy, we propose a three-node motif reduced
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Rab3a attenuates spinal cord injury by mediating vesicle release Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Yuhao Yang, Ziqiao Liu, Yang Lu, Xincheng Yu, Rui Zhu, Xingda Cai, Jinghua Lin, Zemin Wang, Dingsheng Zha
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EEG brain network variability is correlated with other pathophysiological indicators of critical patients in neurology intensive care unit Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-15 Chunli Chen, Zhaojin Chen, Meiling Hu, Sha Zhou, Shiyun Xu, Guan Zhou, Jixuan Zhou, Yuqin Li, Baodan Chen, Dezhong Yao, Fali Li, Yizhou Liu, Simeng Su, Peng Xu, Xuntai Ma
Continuous electroencephalogram (cEEG) plays a crucial role in monitoring and postoperative evaluation of critical patients with extensive EEG abnormalities. Recently, the temporal variability of dynamic resting-state functional connectivity has emerged as a novel approach to understanding the pathophysiological mechanisms underlying diseases. However, little is known about the underlying temporal
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Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-18 Kirti Garg, M. Hasan Mohajeri
The link between drug-induced dysbiosis and its influence on brain diseases through gut-residing bacteria and their metabolites, named the microbiota-gut-brain axis (MGBA), remains largely unexplored. This review investigates the effects of commonly prescribed drugs (metformin, statins, proton-pump-inhibitors, NSAIDs, and anti-depressants) on the gut microbiota, comparing the findings with altered
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Hemodynamic signal changes during volitional swallowing in dysphagia patients with different unilateral hemispheric stroke and brainstem stroke: A near-infrared spectroscopy study Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-15 Xiancong Ma, Yang Peng, Lida Zhong, Fang Li, Zhouquan Tang, Xiao Bao, Jingjun Chen
Background and objectives Strokes will result in decreased in cortical excitability and changed in the balance between the affected and unaffected hemispheres. Previous studies have focused on cortical changes in healthy subjects during swallowing, while they remain unknown in patients with stroke at different locations. Thus, the purpose of this study was to research cortical activation patterns of
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Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-09 Xiao-xi Zheng, Cheng-feng Zhang, Li-qing Li, Jun-rui Ye, Si-yu Ren, Zhao Zhang, Xin He, Shi-feng Chu, Nai-hong Chen
Context Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has been shown to exhibit anti-depressive effects in clinical trials. However, the direct mechanism underlying its effect on neuroinflammation remains unclear. Neuroinflammatory reaction from astrocytes leads to depression, and our previous study found that gap junction disorder between astrocytes aggravated neuroinflammatory reaction
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Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-12 Yidan Liang, Yanglingxi Wang, Chao Sun, Yi Xiang, Yongbing Deng
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly contributes to poor patient outcomes. Recent studies revealed the involvement of iron metabolism in neuronal survival, yet its effect on vasculature remains unclear. This study aims to explore the impact of endothelial ferroptosis on cerebrovascular function in TBI. A Controlled Cortical Impact (CCI) model was established
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Nrf-2 modulates excitability of hippocampal neurons by regulating ferroptosis and neuroinflammation after subarachnoid hemorrhage in rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-11 Dazhao Fang, Shenquan Guo, Boyang Wei, Wenchao Liu, Guangxu Li, Xifeng Li, Jiahui Liu, Lei Jin, Chuanzhi Duan
Excitability of hippocampal neurons in subarachnoid hemorrhage (SAH) rats has not been well studied. The rat SAH model was applied in this study to explore the role of nuclear factor E2-related factor (Nrf-2) in the early brain injury of SAH. The neural excitability of CA1 pyramidal cells (PCs) in SAH rats was evaluated by using electrophysiology experiments. Ferroptosis and neuroinflammation were
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Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-05 Jinqi Lu, Jin Wang, Haibo Ni, Bing Li, Jingjing Yang, Jie Zhu, Jie Qian, Rong Gao, Rong Xu
Traumatic brain injury (TBI) is a common disease worldwide with high mortality and disability rates. Besides the primary mechanical injury, the secondary injury associated with TBI can also induce numerous pathological changes, such as brain edema, nerve apoptosis, and neuroinflammation, which further aggravates neurological dysfunction and even causes the death due to the primary injury. Among them
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The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-10 Guodong Wang, Zhengyan Zhang, Junmei Li, Jinhong Han, Chengbiao Lu
Numb is an evolutionarily conserved protein that regulates the differentiation of neuronal progenitor cells through unknown mechanisms. Numb has four alternative splice variants with different lengths of phosphotyrosine-binding (PTB) and proline-rich regions (PRR) domains. In this study, we demonstrated that Numb expression was increased in the primary cultures of rat cortical and hippocampal neurons
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Disruption of TLE epileptiform activity retarded the seizure and reduced pathological HFOs Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-04 Fengru Guo, Airui Li, Qinjun Liu, Daqing Guo, Ke Chen, Dezhong Yao, Yan Cui, Yang Xia
In temporal lobe epilepsy (TLE), the epileptogenic zones, such as the temporal lobe structure, could generate pathological high-frequency oscillations (pHFOs, 250–500 Hz) before the ictal period. These pHFOs have also been observed during the process of seizures in both TLE patients and animals, exhibiting a critical role as promising biomarkers for TLE seizures. TLE seizures could be modulated via
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Linarin ameliorates ischemia-reperfusion injury by the inhibition of endoplasmic reticulum stress targeting AKR1B1 Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-03 Yuqian Zhang, Shenghan Gao, Shengnan Xia, Haiyan Yang, Xinyu Bao, Qingxiu Zhang, Yun Xu
Due to various factors, there is still a lack of effective neuroprotective agents for ischemic stroke in clinical practice. Neuroinflammation and neuronal apoptosis mediated by endoplasmic reticulum stress are some of the important pathological mechanisms in ischemic stroke. Linarin has been reported to have anti-inflammation, antioxidant, and anti-apoptotic effects in myocardial ischemia, osteoarthritis
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Brain endothelial CD200 signaling protects brain against ischemic damage Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-28 Afzal Misrani, Conelius Ngwa, Abdullah Al Mamun, Romana Sharmeen, Kanaka Valli Manyam, Rodney M. Ritzel, Louise McCullough, Fudong Liu
Ischemic stroke induced inflammatory responses contribute significantly to neuronal damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an endogenous inhibitory signaling that is being increasingly recognized in studies of neuroinflammation in various central nervous system disorders. CD200 is a type 1 membrane glycoprotein that is broadly expressed by endothelia and neurons
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Corrigendum to “NLRP3 inflammasome inhibition by histone acetylation ameliorates sevoflurane-induced cognitive impairment in aged mice by activating the autophagy pathway” [Brain Res. Bull. 172 (2021) 79–88] Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-23 Peng Fang, Chang Chen, Feng Zheng, Junke Jia, Ting Chen, Jinpiao Zhu, Jing Chang, Zongze Zhang
Abstract not available
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Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-21 Shahab Ghaderi, Masome Rashno, Alireza Sarkaki, Seyed Esmaeil Khoshnam
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Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-19 Xianhui Peng, Natalie Wellard, Anshua Ghosh, Claire Troakes, K. Peter Giese
In humans, the cytoplasmic FMR1 interacting protein (CYFIP) family consists of two members, namely CYFIP1 and CYFIP2. Both CYFIP1 and CYFIP2 function in the WAVE regulatory complex (WRC), which regulates actin polymerization. Additionally, these two proteins form a posttranscriptional regulatory complex with the fragile X mental retardation protein (FMRP), which suppresses mRNA translation. Thus, CYFIP1
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Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-21 Ke Chen, Xin Qi, Lin-lin Zhu, Mei-li Li, Bin Cong, Ying-min Li
Based on the successful establishment of a rat model of chronic restraint stress, we used multiple algorithms to quantify the morphological changes of rat hypothalamic microglia from various perspectives, providing a pathomorphological basis for the subsequent study of molecular mechanisms of hypothalamic stress injury, such as neuroinflammation. To verify the successful establishment of the chronic
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Gut microbiome and metabolic profiles of mouse model for MeCP2 duplication syndrome Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-23 Junfang Wu, Qingyu Hu, Xiaoping Rao, Hongyang Zhao, Huiru Tang, Yulan Wang
The extra copy of the methyl-CpG-binding protein 2 (MeCp2) gene causes MeCP2 duplication syndrome (MDS), a neurodevelopmental disorder characterized by intellectual disability and autistic phenotypes. However, the disturbed microbiome and metabolic profiling underlying the autistic-like behavioral deficits of MDS are rarely investigated. Here we aimed to understand the contributions of microbiome disruption
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Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-23 Yue Liang, Ling Chen, Yanmei Huang, Lihua Xie, Xueqin Liu, Wenyan Zhou, Wenyu Cao, Zuyao Chen, Xiaolin Zhong
Chronic pain can induce not only nociceptive but also depressive emotions. A previous study demonstrated that betaine, a commonly used nutrient supplement, has an anti-nociceptive effect, but whether betaine can alleviate chronic pain-induced depressive emotion is elusive. Our current study found that betaine administration significantly eliminated complete Freund’s adjuvant (CFA)-induced pain-related
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Neuroprotective role of FOXA1 in Parkinson's disease: Involvements of NF1 transcription activation and MAPK signaling pathway inhibition Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-22 Yu Fan, Meili Zhao, Fei Hao, Ruyi Sun, Jinyu Chen, Jiahui Liu
Forkhead box A1 (FOXA1), a member of the forkhead family of transcription factors, plays a crucial role in the development of various organ systems and exhibits neuroprotective properties. This study aims to investigate the effect of FOXA1 on Parkinson's disease (PD) and unravel the underlying mechanism. Transcriptome analysis of PD was conducted using three GEO datasets to identify aberrantly expressed
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Predicting response to repetitive transcranial magnetic stimulation in patients with chronic insomnia disorder using electroencephalography: A pilot study Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-21 Lin Zhu, Zian Pei, Ge Dang, Xue Shi, Xiaolin Su, Xiaoyong Lan, Chongyuan Lian, Nan Yan, Yi Guo
Predicting responsvienss to repetitive transcranial magnetic stimulation (rTMS) can facilitate personalized treatments with improved efficacy; however, predictive features related to this response are still lacking. We explored whether resting-state electroencephalography (rsEEG) functional connectivity measured at baseline or during treatment could predict the response to 10-day rTMS targeted to the
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Discriminative analysis of schizophrenia patients using an integrated model combining 3D CNN with 2D CNN: A multimodal MR image and connectomics analysis Brain Res. Bull. (IF 3.8) Pub Date : 2023-12-15 Haiman Guo, Shuyi Jian, Yubin Zhou, Xiaoyi Chen, Jinbiao Chen, Jing Zhou, Yuanyuan Huang, Guolin Ma, Xiaobo Li, Yuping Ning, Fengchun Wu, Kai Wu
Objective Few studies have applied deep learning to the discriminative analysis of schizophrenia (SZ) patients using the fusional features of multimodal MRI data. Here, we proposed an integrated model combining a 3D convolutional neural network (CNN) with a 2D CNN to classify SZ patients. Method Structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) data were acquired for 140 SZ patients