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Cdc42 activation is necessary for heterosynaptic cooperation and competition Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-02-28 Mariana Nunes, Natália Madeira, Rosalina Fonseca
Synapses change their weights in response to neuronal activity and in turn, neuronal networks alter their response properties and ultimately allow the brain to store information as memories. As for memories, not all events are maintained over time. Maintenance of synaptic plasticity depends on the interplay between functional changes at synapses and the synthesis of plasticity-related proteins that
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Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-02-06 Susannah S. Adel, Zachary J. Pranske, Tess F. Kowalski, Nicole Kanzler, Roshni Ray, Catherine Carmona, Suzanne Paradis
Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens of molecular families such as cell adhesion molecules (CAMs) and ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins). Due to the large number of molecular players and possible functional redundancies within gene families, it is challenging to determine the
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A neural mass model for disturbance of alpha rhythm in the minimal hepatic encephalopathy Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-02-01 Jiangling Song, M. Brandon Westover, Rui Zhang
One of the early markers of minimal hepatic encephalopathy (MHE) is the disruption of alpha rhythm observed in electroencephalogram (EEG) signals. However, the underlying mechanisms responsible for this occurrence remain poorly understood. To address this gap, we develop a novel biophysical model MHE-AWD-NCM, encompassing the communication dynamics between a cortical neuron population (CNP) and an
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Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-02-01 Mudiwa N. Muwanigwa, Jennifer Modamio-Chamarro, Paul M.A. Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C. Schwamborn
Parkinson's disease (PD) is a complex, progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain. Despite extensive research efforts, the molecular and cellular changes that precede neurodegeneration in PD are poorly understood. To address this, here we describe the use of patient specific human midbrain organoids harboring
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TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-01-19 E, m, i, l, i, a, , Z, g, o, r, z, y, n, s, k, a
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Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2024-01-19 C. Beretta, E. Svensson, A. Dakhel, M. Zyśk, J. Hanrieder, D. Sehlin, W. Michno, A. Erlandsson
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Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-12-23 Hao Huang, Ling Chen, Jinxian Yuan, Haiqing Zhang, Juan Yang, Zucai Xu, Yangmei Chen
The EphB receptor tyrosine kinase family participates in intricate signaling pathways that orchestrate neural networks, guide neuronal axon development, and modulate synaptic plasticity through interactions with surface-bound ephrinB ligands. Additionally, Kalirin, a Rho guanine nucleotide exchange factor, is notably expressed in the postsynaptic membrane of excitatory neurons and plays a role in synaptic
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The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-12-11 Chris J. Kang, Luis E. Guzmán-Clavel, Katherine Lei, Martin Koo, Steven To, John P. Roche
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Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-12-05 Ayako Ito, Claire Miller, Fumiaki Imamura
Fibroblast growth factors (FGFs) and bone morphogenic proteins (BMPs) play various important roles in the development of the central nervous system. However, the roles of FGF and BMP signaling in the development of the olfactory bulb (OB) are largely unknown. In this study, we first showed the expression of FGF receptors (FGFRs) and BMP receptors (BMPRs) in OB RGCs, radial glial cells (RGCs) in the
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Neuron navigators: A novel frontier with physiological and pathological implications Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-11-14 Parth Sandeep, Poonam Sharma, Kanishk Luhach, Neerupma Dhiman, Harsha Kharkwal, Bhupesh Sharma
Neuron navigators are microtubule plus-end tracking proteins containing basic and serine rich regions which are encoded by neuron navigator genes (NAVs). Neuron navigator proteins are essential for neurite outgrowth, neuronal migration, and overall neurodevelopment along with some other functions as well. The navigator proteins are substantially expressed in the developing brain and have been reported
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Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-11-02 Rebecca S. Revol, Niina A. Koistinen, Preeti K. Menon, Almudena Chicote-Gonzàlez, Kerstin Iverfeldt, Anna-Lena Ström
Fe65 is a brain enriched adaptor protein involved in various cellular processes, including actin cytoskeleton regulation, DNA repair and transcription. A well-studied interacting partner of Fe65 is the transmembrane amyloid-β precursor protein (APP), which can undergo regulated intramembrane proteolysis (RIP). Following β- and γ-secretase-mediated RIP, the released APP intracellular domain (AICD) together
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The elastin-derived peptide (VGVAPG) activates autophagy in neuroblastoma (SH-SY5Y) cells via peroxisome proliferator-activated receptor gamma (PPARγ) Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-11-02 Konrad A. Szychowski, Bartosz Skóra
Autophagy is a self-degradative process important for balancing the sources of energy and involved in the development of Alzheimer's disease (AD). To date, a number of papers have shown that elastin-derived peptides (EDPs) affect the expression and activation of peroxisome proliferator-activated receptor gamma (PPARγ), which is crucial for the development of AD and autophagy initiation. Therefore,
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Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-10-31 Dibyakanti Mishra, Priyam Narain, Upma Dave, James Gomes
Optineurin (OPTN) gene is a marker of amyotrophic lateral sclerosis (ALS). However, the role of optineurin protein (OPTN) in ALS pathology is unclear, even though it is known to regulate autophagy, apoptosis, and other survival-death cellular processes. Genetic analysis of Indian ALS patients by our group ascertained a novel mutation K489E in the OPTN gene. To identify the molecular mechanism associated
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The intrinsic apoptotic pathway lies upstream of reactive species production in cortical neurons and age-related oxidative stress in the brain Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-09-18 Kyndra Stovall, Mital Patel, James L. Franklin
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The NIDA Avenir award in genetics or epigenetics of substance use disorders Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-09-20 John S. Satterlee, Jonathan D. Pollock, Nora D. Volkow
NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs) was launched to support early stage investigators who propose innovative, high risk, but potentially high impact research and who show promise of being tomorrow's leaders in this scientific field. Since 2015, NIDA has supported 30 Avenir Investigators with unique expertise and creative ideas. This special issue showcases
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Efferent axons in the zebrafish lateral line degenerate following sensory hair cell ablation Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-09-13 Melek Umay Tuz-Sasik, Remy Manuel, Henrik Boije
The zebrafish lateral line is a frequently used model to study the mechanisms behind peripheral neuronal innervation of sensory organs and the regeneration thereof. The lateral line system consists of neuromasts, a cluster of protruding hair cells, which are innervated by sensory afferent and modulatory efferent neurons. These flow-sensing hair cells are similar to the hair cells in the mammalian ear
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Genetics and epigenetics approaches as a path to the future of addiction science Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-30 Anne E. West, Jeremy J. Day
Abstract not available
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An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-25 Chen Mo, Zhenyao Ye, Yezhi Pan, Yuan Zhang, Qiong Wu, Chuan Bi, Song Liu, Braxton Mitchell, Peter Kochunov, L. Elliot Hong, Tianzhou Ma, Shuo Chen
In the last two decades of Genome-wide association studies (GWAS), nicotine-dependence-related genetic loci (e.g., nicotinic acetylcholine receptor – nAChR subunit genes) are among the most replicable genetic findings. Although GWAS results have reported tens of thousands of SNPs within these loci, further analysis (e.g., fine-mapping) is required to identify the causal variants. However, it is computationally
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Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-18 Ellen M. Armour, Christina M. Thomas, Gabrielle Greco, Akanksha Bhatnagar, Felice Elefant
Nucleocytoplasmic transport (NCT) in neurons is critical for enabling proteins to enter the nucleus and regulate plasticity genes in response to environmental cues. Such experience-dependent (ED) neural plasticity is central for establishing memory formation and cognitive function and can influence the severity of neurodegenerative disorders like Alzheimer's disease (AD). ED neural plasticity is driven
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Glutamine metabolism in diseases associated with mitochondrial dysfunction Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-15 Rebecca Bornstein, Michael T. Mulholland, Margaret Sedensky, Phil Morgan, Simon C. Johnson
Mitochondrial dysfunction can arise from genetic defects or environmental exposures and impact a wide range of biological processes. Among these are metabolic pathways involved in glutamine catabolism, anabolism, and glutamine-glutamate cycling. In recent years, altered glutamine metabolism has been found to play important roles in the pathologic consequences of mitochondrial dysfunction. Glutamine
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Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-10 Chandan Kumar Maurya, Madhu G. Tapadia
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Special issue: Synaptic logistics — Maintenance of synaptic composition, properties and function Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-08-07 Noam E. Ziv, Antoine Triller
Abstract not available
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Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine model of Parkinsons disease Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-30 Tanya Denne, Lila C. Winfrey, Cindy Moore, Chase Whitner, Theresa D'Silva, Amala Soumyanath, Lynne Shinto, Amie Hiller, Charles K. Meshul
There is growing interest in the use of natural products for the treatment of Parkinson's disease (PD). Mucuna pruriens has been used in the treatment of humans with PD. The goal of this study was to determine if daily oral treatment with an extract of Mucuna pruriens, starting after the MPTP-induced loss of nigrostriatal dopamine in male mice, would result in recovery/restoration of motor function
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The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-26 Haicong Zhou, Jiao Wang, Tieqiao Wen
Owing to the continuous increase in human life expectancy, the management of aging-related diseases has become an urgent issue. The brain dominates the central nervous system; therefore, brain aging is a key area of aging-related research. We previously uncovered that dendritic cell factor 1 (Dcf1) maintains the stemness of neural stem cells and its expression in Drosophila can prolong lifespan, suggesting
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The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-16
Introduction Niemann-Pick type C2 disease (NP-C2) is a fatal neurovisceral disorder caused by defects in the lysosomal cholesterol transporter protein NPC2. Consequently, cholesterol and other lipids accumulate within the lysosomes, causing a heterogeneous spectrum of clinical manifestations. Murine models are essential for increasing the understanding of the complex pathology of NP-C2. This study
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Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-18
Background The pathophysiological mechanism underlying chemotherapy-induced neuropathic pain (CINP) remains unclear. Sensory neuronal hypersensitivity in the dorsal root ganglion (DRG) is essential for the onset and maintenance of chronic pain. Satellite glial cells (SGCs) in the DRG potentially affect the function of sensory neurons, possibly by mediating extracellular or paracrine signaling. Exosomes
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CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-20 Katarzyna Grycel, Nick Y. Larsen, Yinghang Feng, Klaus Qvortrup, Poul Henning Jensen, Mishal Fayyaz, Malene G. Madsen, Jens Midtgaard, Zhiheng Xu, Stine Hasselholt, Jens R. Nyengaard
Collapsin response mediator protein 2 (CRMP2) is a member of a protein family, which is highly involved in neurodevelopment, but most of its members become heavily downregulated in adulthood. CRMP2 is an important factor in neuronal polarization, axonal formation and growth cone collapse. The protein remains expressed in adulthood, but is more region specific. CRMP2 is present in adult corpus callosum
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Systemic inflammation induced from remote extremity trauma is a critical driver of secondary brain injury Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-12
Blast exposure, commonly experienced by military personnel, can cause devastating life-threatening polysystem trauma. Despite considerable research efforts, the impact of the systemic inflammatory response after major trauma on secondary brain injury-inflammation is largely unknown. The aim of this study was to identify markers underlying the susceptibility and early onset of neuroinflammation in three
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Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2 Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-07-08 Faith C.J. Davies, Grant F. Marshall, Eleanor Pegram, Danni Gadd, Catherine M. Abbott
All vertebrate species express two independently-encoded forms of translation elongation factor eEF1A. In humans and mice eEF1A1 and eEF1A2 are 92 % identical at the amino acid level, but the well conserved developmental switch between the two variants in specific tissues suggests the existence of important functional differences. Heterozygous mutations in eEF1A2 result in neurodevelopmental disorders
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Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-28 Ryan Tam, Albert J. Keung
Transcriptomic responses to neurotransmitters contribute to the complex processes driving memory and addiction. Advances in both measurement methods and experimental models continue to improve our understanding of this regulatory layer. Here we focus on the experimental potential of stem cell derived neurons, currently the only ethical model that can be used in reductionist and experimentally perturbable
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Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-27 Dana Zeid, Andre B. Toussaint, Carmen C. Dressler, Samuel P. Schumacher, Chau Do, Heather Desalvo, Danait Selamawi, Angela R. Bongiovanni, Hannah L. Mayberry, Gregory V. Carr, Mathieu E. Wimmer
The ongoing opioid addiction crisis necessitates the identification of novel risk factors to improve prevention and treatment of opioid use disorder. Parental opioid exposure has recently emerged as a potential regulator of offspring vulnerability to opioid misuse, in addition to heritable genetic liability. An understudied aspect of this “missing heritability” is the developmental presentation of
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The intracellular C-terminal domain of mGluR6 contains ER retention motifs Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-21 Atsushi Shimohata, Dilip Rai, Takumi Akagi, Sumiko Usui, Ikuo Ogiwara, Makoto Kaneda
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Effect of germ-free status on transcriptional profiles in the nucleus accumbens and transcriptomic response to chronic morphine Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-12 Jonathon P. Sens, Rebecca S. Hofford, Drew D. Kiraly
Opioid use disorder is a public health crisis that causes tremendous suffering for patients as well as substantial social and economic costs for society. There are currently available treatments for patients with opioid use disorder, but they remain intolerable or ineffective for many. Thus the need to develop new avenues for therapeutics development in this space is great. Substantial work in models
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Proglucagon signalling in the rat Dorsomedial Hypothalamus – Physiology and high-fat diet-mediated alterations Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-08 A.M. Sanetra, K. Palus-Chramiec, L. Chrobok, J.S. Jeczmien-Lazur, J.D. Klich, M.H. Lewandowski
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Consequences of oxygen deprivation on myelination and sex-dependent alterations Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-06-01 Rafael Bandeira Fabres, Débora Sterzeck Cardoso, Brian Aranibar Aragón, Bruna Petrucelli Arruda, Pamela Pinheiro Martins, Juliane Midori Ikebara, Alexander Drobyshevsky, Alexandre Hiroaki Kihara, Luciano Stürmer de Fraga, Carlos Alexandre Netto, Silvia Honda Takada
Oxygen deprivation is one of the main causes of morbidity and mortality in newborns, occurring with a higher prevalence in preterm infants, reaching 20 % to 50 % mortality in newborns in the perinatal period. When they survive, 25 % exhibit neuropsychological pathologies, such as learning difficulties, epilepsy, and cerebral palsy. White matter injury is one of the main features found in oxygen deprivation
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Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-31 Shayla A. Vradenburgh, Amy L. Van Deusen, Allison N. Beachum, Jacqueline M. Moats, Ashley K. Hirt, Christopher D. Deppmann, Austin B. Keeler, Eli R. Zunder
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A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-31 Noelle C. Punessen, Claudia Pena, Alexandra Sandberg, Lilia A. Koza, Daniel A. Linseman
Neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer's and Parkinson's disease are caused by a progressive and aberrant destruction of neurons in the brain and spinal cord. These disorders lack effective long-term treatments that impact the underlying mechanisms of pathogenesis and as a result, existing options focus primarily on alleviating symptomology. Dysregulated programmed
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Glycogen phosphorylase isoenzyme GPbb versus GPmm regulation of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and counter-regulatory hormone profiles during hypoglycemia: Role of L-lactate and octadecaneuropeptide Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-31 Md. Main Uddin, Md. Haider Ali, A.S.M.H. Mahmood, Khaggeswar Bheemanapally, Jérôme Leprince, Karen P. Briski
Glucose accesses the brain primarily via the astrocyte cell compartment, where it passes through the glycogen shunt before catabolism to the oxidizable fuel L-lactate. Glycogen phosphorylase (GP) isoenzymes GPbb and GPmm impose distinctive control of ventromedial hypothalamic nucleus (VMN) glucose-regulatory neurotransmission during hypoglycemia, but lactate and/or gliotransmitter involvement in those
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The long-loop recycling (LLR) of synaptic components as a question of economics Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-24 Svilen Veselinov Georgiev, Silvio O. Rizzoli
The pre- and post-synaptic compartments contain a variety of molecules that are known to recycle between the plasma membrane and intracellular organelles. The recycling steps have been amply described in functional terms, with, for example, synaptic vesicle recycling being essential for neurotransmitter release, and postsynaptic receptor recycling being a fundamental feature of synaptic plasticity
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Sex differences in susceptibility to substance use disorder: Role for X chromosome inactivation and escape? Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-18 Kate Krueger, Felipe Lamenza, Howard Gu, Heithem El-Hodiri, Jason Wester, John Oberdick, Andy J. Fischer, Steve Oghumu
There is a sex-based disparity associated with substance use disorders (SUDs) as demonstrated by clinical and preclinical studies. Females are known to escalate from initial drug use to compulsive drug-taking behavior (telescoping) more rapidly, and experience greater negative withdrawal effects than males. Although these biological differences have largely been attributed to sex hormones, there is
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Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3 Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-12 Carola Tapia-Monsalves, Margrethe A. Olesen, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla
During Alzheimer's (AD), tau protein suffers from abnormal post-translational modifications, including cleaving by caspase-3. These tau forms affect synaptic plasticity contributing to the cognitive decline observed in the early stages of AD. In addition, caspase-3 cleaved tau (TauC3) impairs mitochondrial dynamics and organelles transport, which are both relevant processes for synapse. We recently
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Synaptic logistics: Competing over shared resources Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-10 Anne-Sophie Hafner, Jochen Triesch
High turnover rates of synaptic proteins imply that synapses constantly need to replace their constituent building blocks. This requires sophisticated supply chains and potentially exposes synapses to shortages as they compete for limited resources. Interestingly, competition in neurons has been observed at different scales. Whether it is competition of receptors for binding sites inside a single synapse
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The extent of damage to the blood-brain barrier in the hypercholesterolemic LDLR−/−/Apo E−/− double knockout mice depends on the animal's age, duration of pathology and brain area Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-12 Ewelina Czuba-Pakuła, Sebastian Głowiński, Sławomir Wójcik, Grażyna Lietzau, Magdalena Zabielska-Kaczorowska, Przemysław Kowiański
One of the effects of hypercholesterolemia (Hch) exerted on the central nervous system (CNS) is damage to the blood-brain barrier (BBB). Increased permeability of BBB results from structural changes in the vascular wall, loss of the tight junctions and barrier function, as well as alterations in the concentration of proteins located in the layers of the vascular wall. These changes occur in the course
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Epigenomic profiling of mouse nucleus accumbens at single-cell resolution Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-05-01 Parth Bhatia, Lite Yang, Jay X.J. Luo, Mengyi Xu, William Renthal
The nucleus accumbens (NAc) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. Recent studies have begun to investigate NAc gene expression at a single-cell resolution, however, our understanding of the cellular heterogeneity of the NAc epigenomic landscape remains limited. In this study
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Molecular mechanisms of AMPAR reversible stabilization at synapses Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-25 Diogo Bessa-Neto, Daniel Choquet
In the central nervous system, glutamatergic synapses play a central role in the regulation of excitatory neuronal transmission. With the membrane-associated guanylate kinase (MAGUK) family of proteins as their structuring scaffold, glutamatergic receptors serve as the powerhouse of glutamatergic synapses. Glutamatergic receptors can be categorized as metabotropic and ionotropic receptors. The latter
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The Translocase of the Outer Mitochondrial Membrane (TOM40) is required for mitochondrial dynamics and neuronal integrity in Dorsal Root Ganglion Neurons Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-24 Caitlin Overmeyer, Kylie Jorgensen, Bhupinder P.S. Vohra
Polymorphisms and altered expression of the Translocase of the Outer Mitochondrial Membrane – 40 kD (Tom40) are observed in neurodegenerative disease subjects. We utilized in vitro cultured dorsal root ganglion (DRG) neurons to investigate the association of TOM40 depletion to neurodegeneration, and to unravel the mechanism of neurodegeneration induced by decreased levels of TOM40 protein. We provide
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Deletion of PTEN in microglia ameliorates chronic neuroinflammation following repetitive mTBI Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-20 Andrew Pearson, Camila Ortiz, Max Eisenbaum, Clara Arrate, Mackenzie Browning, Michael Mullan, Corbin Bachmeier, Fiona Crawford, Joseph O. Ojo
Traumatic brain injury is a leading cause of morbidity and mortality in adults and children in developed nations. Following the primary injury, microglia, the resident innate immune cells of the CNS, initiate several inflammatory signaling cascades and pathophysiological responses that may persist chronically; chronic neuroinflammation following TBI has been closely linked to the development of neurodegeneration
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Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-20 Maria Andres-Alonso, Katarzyna M. Grochowska, Eckart D. Gundelfinger, Anna Karpova, Michael R. Kreutz
The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One of these mechanisms concerns the long-distance transport of proteins from pre- and postsynaptic sites to the nucleus. In this review we summarize current
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Pleiotropic loci for cannabis use disorder severity in multi-ancestry high-risk populations Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-14 Qian Peng, Kirk C. Wilhelmsen, Cindy L. Ehlers
Cannabis use disorder (CUD) is common and has in part a genetic basis. The risk factors underlying its development likely involve multiple genes that are polygenetic and interact with each other and the environment to ultimately lead to the disorder. Co-morbidity and genetic correlations have been identified between CUD and other disorders and traits in select populations primarily of European descent
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Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA) Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-04-07 Chelsie E. Benca-Bachman, Jason Bubier, Rameez A. Syed, Pamela N. Romero Villela, Rohan H.C. Palmer
Alcohol withdrawal (AW) is a feature of alcohol use disorder that may occur in up to half of individuals with chronic, heavy alcohol consumption whenever alcohol use is abruptly stopped or significantly reduced. To date, few genes have been robustly associated with AW; this may be partly due to most studies defining AW as a binary construct despite the multiple symptoms and their range in severity
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Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-23 Ilkcan Ercan, Serap Cilaker Micili, Sila Soy, Defne Engur, Kemal Ugur Tufekci, Abdullah Kumral, Sermin Genc
Despite current advancements in neonatal care, hyperbilirubinemia resulting in bilirubin-induced neurological dysfunction (BIND) continues to be one of the major reasons of mortality or lifelong disability. Although the exact mechanisms underlying brain injury upon bilirubin exposure remains unelucidated, inflammation is considered to be one of the major contributors to BIND. This study investigates
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Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-21 Matthew J. Fogarty, Debanjali Dasgupta, Obaid U. Khurram, Gary C. Sieck
Brain derived neurotrophic factor (BDNF) signalling through its high-affinity tropomyosin receptor kinase B (TrkB) is known to have potent effects on motor neuron survival and morphology during development and in neurodegenerative diseases. Here, we employed a novel 1NMPP1 sensitive TrkBF616 rat model to evaluate the effect of 14 days inhibition of TrkB signalling on phrenic motor neurons (PhMNs).
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Erratum to “wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models” [Mol. Cell. Neurosci. 49 (1) (2012), 44–53] Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-23 Preeti J. Khandelwal, Sonya B. Dumanis, Alexander M. Herman, G. William Rebeck, Charbel E.-H. Moussa
Abstract not available
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Chemical tools for the opioids Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-21 Mark Anthony Leon Duque, Nandini Vallavoju, Christina M. Woo
The opioids are potent and widely used pain management medicines despite also possessing severe liabilities that have fueled the opioid crisis. The pharmacological properties of the opioids primarily derive from agonism or antagonism of the opioid receptors, but additional effects may arise from specific compounds, opioid receptors, or independent targets. The study of the opioids, their receptors
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Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-24 Robert A. Phillips, Jennifer J. Tuscher, N. Dalton Fitzgerald, Ethan Wan, Morgan E. Zipperly, Corey G. Duke, Lara Ianov, Jeremy J. Day
Drugs of abuse increase extracellular concentrations of dopamine in the nucleus accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and behavioral adaptations. While decades of research have focused on the transcriptional mechanisms by which drugs of abuse influence neuronal physiology and function, few studies have comprehensively defined NAc cell type heterogeneity
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Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-22 Surbhit Wagle, Nataliya Kraynyukova, Anne-Sophie Hafner, Tatjana Tchumatchenko
Recent advances in experimental techniques provide an unprecedented peek into the intricate molecular dynamics inside synapses and dendrites. The experimental insights into the molecular turnover revealed that such processes as diffusion, active transport, spine uptake, and local protein synthesis could dynamically modulate the copy numbers of plasticity-related molecules in synapses. Subsequently
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Circular RNA regulation and function in drug seeking phenotypes Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-17 Stephanie E. Sillivan, Aria Gillespie
Drug overdoses have increased dramatically in the United States over the last decade where they are now the leading cause of accidental death. To develop efficient therapeutic options for decreasing drug consumption and overdose risk, it is critical to understand the neurobiological changes induced by drug exposure. Chronic systemic exposure to all drug classes, including opioids, psychostimulants
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Astrocyte-associated fibronectin promotes the proinflammatory phenotype of astrocytes through β1 integrin activation Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-21 Pao-Hsien Chu, Shao-Chi Chen, Hsin-Yung Chen, Cheng-Bei Wu, Wei-Ting Huang, Hou-Yu Chiang
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Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain Mol. Cell. Neurosci. (IF 3.5) Pub Date : 2023-03-17 Makoto Shimozawa, Helene Tigro, Henrik Biverstål, Ganna Shevchenko, Jonas Bergquist, Ruin Moaddel, Jan Johansson, Per Nilsson
Proteins must fold into three-dimensional structures to execute their biological functions. Therefore, maintenance of protein homeostasis, proteostasis, including prevention of protein misfolding is essential for cellular activity and health. Molecular chaperones are key actors in proteostasis. BRICHOS domain is an intramolecular chaperone that also interferes with several aggregation-prone proteins