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Daytime Aspartame Intake Results in Larger Influences on Body Weight, Serum Corticosterone Level, Serum/Cerebral Cytokines Levels and Depressive-Like Behaviors in Mice than Nighttime Intake Neurotoxicology (IF 3.4) Pub Date : 2024-03-16 Haiyuan Ma, Jiapeng Deng, Jing Liu, Xiaobao Jin, Junhua Yang
Aspartame (APM) is one of the most widely used artificial sweeteners worldwide. Studies have revealed that consuming APM may negatively affect the body, causing oxidative stress damage to multiple organs and leading to various neurophysiological symptoms. However, it’s still unclear if consuming APM and one's daily biological rhythm have an interactive effect on health. In this study, healthy adult
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Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity Neurotoxicology (IF 3.4) Pub Date : 2024-03-10 Xuedan Deng, Yonghua Guo, Xiaofei Jin, Huifang Si, Kai Dai, Meng Deng, Jing He, Changfu Hao, Wu Yao
Although overexposure to manganese (Mn) is known to cause neurotoxic damage, effective exposure markers for assessing Mn loading in Mn-exposed workers are lacking. Here, we construct a Mn-exposed rat model to perform correlation analysis between Mn-induced neurological damage and Mn levels in various biological samples. We combine this analysis with epidemiological investigation to assess whether Mn
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Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats Neurotoxicology (IF 3.4) Pub Date : 2024-03-06 Raj Katariya, Kartikey Mishra, Shivkumar Sammeta, Milind Umekar, Nandkishor Kotagale, Brijesh Taksande
Huntington's disease (HD) is a progressive neurodegenerative condition characterized by a severe motor incoordination, cognitive decline, and psychiatric complications. However, a definitive cure for this devastating disorder remains elusive. Agmatine, a biogenic amine, has gain attention for its reported neuromodulatory and neuroprotective properties. The present study was designed to examine the
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Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community Neurotoxicology (IF 3.4) Pub Date : 2024-03-06 Khalid M. Khan, Marie E. Gaine, Alyssa R. Daniel, Pavani Chilamkuri, Diane S. Rohlman
Organophosphorus pesticide (OP) exposure is known to have adverse effects on the nervous system. Children from agricultural communities are at risk of exposure to these chemicals from their indoor environments that can lead to neurological and developmental problems, including changes in behavior. The aim of this study is to evaluate whether the take-home pathway exposure is associated with behavioral
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Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster Neurotoxicology (IF 3.4) Pub Date : 2024-02-28 Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbosa
The study investigated the protective effects of Hesperetin (HSP) and Hesperidin (HSD) on 1 methyl, 4 phenyl, 1,2,3,6 tetrahydropyridine hydrochloride (MPTP)-induced Parkinsonism in (). After a lifespan study to select exposure time and concentrations, flies were co-exposed to MPTP (0.4 mg/g diet), Hesperetin (0.2 and 0.4 mg/g diet), and Hesperidin (0.1 and 0.4 mg/g) for 7 days. In addition to parameters
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Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson’s disease stress conditions Neurotoxicology (IF 3.4) Pub Date : 2024-02-22 Fatema Currim, Shatakshi Shukla, Jyoti Singh, Dhruv Gohel, Minal Mane, Anjali Shinde, Milton Roy, Shani Goyani, Hitesh Vasiyani, Aswathy Chandran, Jean-Christophe Rochet, Jason Cannon, Rajesh Singh
Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra part of the brain. Pathology spread to numerous brain regions and cell types suggests that intercellular communication is essential to PD progression. Exosomes mediate intercellular communication between neurons, glia, and other cell types throughout
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Abdominal surgery under ketamine anesthesia during second trimester impairs hippocampal learning and memory of offspring by regulating dendrite spine remodeling in rats Neurotoxicology (IF 3.4) Pub Date : 2024-02-10 Mengdie Wang, Namin Feng, Jia Qin, Shengqiang Wang, Jiabao Chen, Shaojie Qian, Yulin Liu, Foquan Luo
Recent evidence showed that general anesthesia produces long-term neurotoxicity and cognitive dysfunction. However, it remains unclear whether maternal non-obstetric surgery under ketamine anesthesia during second trimester causes cognitive impairment in offspring. The present study assigned pregnant rats into three groups: 1) normal control group receiving no anesthesia and no surgery, 2) ketamine
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Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats Neurotoxicology (IF 3.4) Pub Date : 2024-02-08 Jonathan Sánchez-Yépez, Triana Acevedo-Huergo, Maria Soledad Mendoza-Trejo, Rebeca Corona, Isela Hernández-Plata, Verónica Viñuela-Berni, Magda Giordano, Verónica M Rodríguez
Several studies have shown that chronic exposure to the herbicide atrazine (ATR) causes alterations in locomotor activity and markers of the dopaminergic systems of male rats. However, few studies have evaluated the sex-dependent effects of atrazine exposure. The aim of the present study was to evaluate whether chronic ATR exposure causes alterations in behavioral performance and dopaminergic systems
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Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway Neurotoxicology (IF 3.4) Pub Date : 2024-02-05 Bingxin Zhao, Sheng Zhang, Nashwa Amin, Jie Pan, Fei Wu, Guanghong Shen, Mingming Tan, Zongjie Shi, Yu Geng
Acute ischemic stroke followed by microglia activation, and the regulation of neuroinflammatory responses after ischemic injury involves microglia polarization. microglia polarization is involved in the regulation of neuroinflammatory responses and ischemic stroke-related brain damage. Thymoquinone (TQ) is an anti-inflammatory agent following ischemic stroke onset. However, the significance of TQ in
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Absence of functional deficits in rats following systemic administration of an AAV9 vector despite moderate peripheral nerve and dorsal root ganglia findings: A clinically silent peripheral neuropathy Neurotoxicology (IF 3.4) Pub Date : 2024-02-03 Cheryl Tyszkiewicz, Seo-Kyoung Hwang, Jamie K. DaSilva, Ramesh C. Kovi, Kelly A. Fader, Madhu P. Sirivelu, June Liu, Chris Somps, Jon Cook, Chang-Ning Liu, Helen Wang
Adeno-associated virus (AAV)-based vectors are commonly used for delivering transgenes in gene therapy studies, but they are also known to cause dorsal root ganglia (DRG) and peripheral nerve toxicities in animals. However, the functional implications of these pathologic findings and their time course remain unclear. At 2, 4, 6, and 8 weeks following a single dose of an AAV9 vector carrying human frataxin
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α-synuclein-lack expression rescues methamphetamine-induced mossy fiber degeneration in dorsal hippocampal CA3 Neurotoxicology (IF 3.4) Pub Date : 2024-02-03 Jiuyang Ding, Jun Wu, Xiaotao Hou, Li Yang, Yingdong Gao, Juan Zheng, Nannan Jia, Zheng He, Hui Zhang, Chengfei Wang, Xiaolan Qi, Jiang Huang, Xianglin Pei, Jiawen Wang
Methamphetamine (METH) - induced cognitive impairments may be related to synaptic degeneration at mossy fiber terminals, critical for spatial memory formation in hippocampal circuits. We have previously found METH-induced neurodegeneration in the striatum by increasing the α-synuclein (α-SYN) level. However, whether and how the METH-induced mossy fiber degeneration is also blamed for the abnormal accumulation
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Maternal seafood consumption is associated with improved selenium status: Implications for child health Neurotoxicology (IF 3.4) Pub Date : 2024-01-23 Nicholas V.C. Ralston, Laura J. Raymond, Christy L. Gilman, Reni Soon, Lucia A. Seale, Marla J. Berry
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Human blood markers of cholinergic neurotoxicity and neuropathy: A useful guide for laboratory applications Neurotoxicology (IF 3.4) Pub Date : 2024-01-13 Guilherme Luz Emerick, Valfran da Silva Lima, Bruna Francisquete Costa, Vitoria Hioko da Silva Nakamura, Dayana Veruska Lentz, Juliandra Spagnol Bonache, Marion Ehrich
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are useful markers to assess the effects of exposure to anticholinesterase insecticides (Anti-AChE). In addition, lymphocyte neuropathy target esterase (LNTE) has been used as biomarker of neuropathic organophosphate compounds (OPs). Thus, this study evaluates the main types of circulating biomarkers related to the cholinergic system and
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Occupational exposure to polychlorinated biphenyls: Development of neuropsychological functions over time Neurotoxicology (IF 3.4) Pub Date : 2024-01-11 Julia L. Cromberg, Thomas Schettgen, Klaus Willmes, Jessica Lang, Thomas Kraus, Bruno Fimm
Occupational exposure to polychlorinated biphenyls (PCBs) continues to affect the health of exposed individuals until today. This study aims to expand previous findings by examining the development of neuropsychological functions of occupationally exposed participants over time. Especially verbal fluency and sensorimotor processing, found to be impaired in a previous study, were thus of particular
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Vitamin A ameliorates valproic acid-induced autism-like symptoms in developing zebrafish larvae by attenuating oxidative stress and apoptosis Neurotoxicology (IF 3.4) Pub Date : 2024-01-06 Jingyu Wang, Li Zou, Peiyun Jiang, Mengmeng Yao, Qu Xu, Qin Hong, Jiansheng Zhu, Xia Chi
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Corrigendum to “In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice” NeuroToxicology 83 (2021) 1–13 Neurotoxicology (IF 3.4) Pub Date : 2023-12-23 Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
Abstract not available
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Expression of concern: “Assessment of the neuroprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in rats” [Neurotoxicology, Volume 95, Pages 232-243] Neurotoxicology (IF 3.4) Pub Date : 2023-12-21
Abstract not available
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Corrigendum to “In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice” [NeuroToxicology, 83 (2021), 1–13] Neurotoxicology (IF 3.4) Pub Date : 2023-12-21 Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
Abstract not available
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The role of carbon monoxide in aerotoxic syndrome Neurotoxicology (IF 3.4) Pub Date : 2023-12-21 G. Hageman, P. van Broekhuizen, J. Nihom
Chronic low-level exposure to toxic compounds in airplane cabin air may result in Aerotoxic Syndrome (AS). Aetiologic agents are organophosphates and numerous volatile organic hydrocarbons originating from leaks of engine oil and hydraulic fluids. Despite a documented history spanning decades, the role of carbon monoxide remains controversial. What evidence exists that carbon monoxide (CO), present
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Dietary selenium and mercury intakes from fish consumption during pregnancy: Seychelles Child Development Study Nutrition Cohort 2 Neurotoxicology (IF 3.4) Pub Date : 2023-12-20 Maria Wesolowska, Alison J. Yeates, Emeir M. McSorley, Gene E. Watson, Edwin van Wijngaarden, Nathalie Bodin, Rodney Govinden, Juddy Jean-Baptiste, Stephanie Desnousse, Conrad F. Shamlaye, Gary J. Myers, J.J. Strain, Maria S. Mulhern
Some health agencies have issued precautionary principle fish advisories to pregnant women based on the presence of methylmercury (MeHg) in fish that could possibly be harmful to the developing fetus. Fish, however, is a rich source of selenium (Se) and other nutrients essential for normal brain development. Selenium is also thought to have a key role in alleviating MeHg toxicity. We estimated the
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Synchrotron speciation of umbilical cord mercury and selenium after environmental exposure in Niigata Neurotoxicology (IF 3.4) Pub Date : 2023-12-20 Monica Weng, Natalia V. Dolgova, Linda I. Vogt, Muhammad Qureshi, Dimosthenis Sokaras, Thomas Kroll, Hisashi Saitō, John L. O’Donoghue, Gene E. Watson, Gary J. Myers, Tomoko Sekikawa, Ingrid J. Pickering, Graham N. George
The insidious and deadly nature of mercury’s organometallic compounds is informed by two large scale poisonings due to industrial mercury pollution that occurred decades ago in Minamata and Niigata, Japan. The present study examined chemical speciation for both mercury and selenium in a historic umbilical cord sample from a child born to a mother who lived near the Agano River in Niigata. The mother
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Cobalt-induced apoptosis of cochlear organotypic cultures and HEI-OC1 cells is mediated by Dicer Neurotoxicology (IF 3.4) Pub Date : 2023-12-13 Xuexin Lin, Liling Li, Jia Luo, Dan Chen, Jingqian Tan, Peng Li
Cobalt is widely used in the medical industry, mainly including cobalt alloy joint implants and cobalt-chromium porcelain crowns. However, unexplained ototoxicity and neurotoxicity often occur in the clinical use of cobalt agents at present, which limits the development of the cobalt industry. In this study, based on the clinical problem of cobalt ototoxicity, we first conducted an extensive search
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The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice Neurotoxicology (IF 3.4) Pub Date : 2023-12-09 Janine Cubello, Elena Marvin, Katherine Conrad, Alyssa K. Merrill, Jithin V. George, Kevin Welle, Brian P. Jackson, David Chalupa, Günter Oberdörster, Marissa Sobolewski, Deborah A. Cory-Slechta
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal period in mice (equivalent to human third trimester brain development) produce male-biased changes in brain structure, including ventriculomegaly, reduced brain myelination, alterations in neurotransmitters and glial activation, as well as impulsive-like behavioral characteristics, all of which are also features
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Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans Neurotoxicology (IF 3.4) Pub Date : 2023-12-08 Andrew S. Clark, Javier Huayta, Katherine S. Morton, Joel N. Meyer, Adriana San-Miguel
Caenorhabditis elegans (C. elegans) is an excellent model system to study neurodegenerative diseases, such as Parkinson’s disease, as it enables analysis of both neuron morphology and function in live animals. Multiple structural changes in neurons, such as cephalic dendrite morphological abnormalities, have been considered hallmarks of neurodegeneration in this model, but their relevance to changes
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Predicted versus observed activity of PCB mixtures toward the ryanodine receptor Neurotoxicology (IF 3.4) Pub Date : 2023-12-07 Justin A. Griffin, Xueshu Li, Hans-Joachim Lehmler, Erika B. Holland
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Preferential potentiation of AMPA-mediated currents in brainstem hypoglossal motoneurons by subchronic exposure of mice expressing the human superoxide dismutase 1 G93A gene mutation to neurotoxicant methylmercury in vivo Neurotoxicology (IF 3.4) Pub Date : 2023-12-07 Yukun Yuan, Jordan M. Bailey, Gretchen M. Rivera-Lopez, William D. Atchison
The exact causes of Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurological disorder due to loss of upper and/or lower motoneurons, remain elusive. Gene-environment interactions are believed to be an important factor in the development of ALS. We previously showed that in vivo exposure of mice overexpressing the human superoxide dismutase 1 (hSOD1) gene mutation (hSOD1G93A; G93A)
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Characterizing cannabis-prevalent terpenes for neuroprotection reveal a role for α and β-pinenes in mitigating amyloid β-evoked neurotoxicity and aggregation in vitro Neurotoxicology (IF 3.4) Pub Date : 2023-12-07 John Staton Laws, Scott D. Smid
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Necroptosis involved in sevoflurane-induced cognitive dysfunction in aged mice by activating NMDA receptors increasing intracellular calcium Neurotoxicology (IF 3.4) Pub Date : 2023-12-07 Xiang Liu, Jiaxu Yu, Xiaona Tan, Qi Zhang, Junfang Niu, Zhiyong Hou, Qiujun Wang
Perioperative neurocognitive disorders are a common surgical and postanesthesia complication. Necroptosis contributes to the emergence of various neurological disorders. We conjecture that cognitive impairment is associated with necroptosis of hippocampal neurons, which is mediated by NMDA receptors leading to cytoplasmic calcium imbalance. C57BL/6 J male mice ( 18 months) were randomly divided into
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Mohamed Bahie Abou-Donia: Pioneer in organophosphorus-induced neurotoxicity Neurotoxicology (IF 3.4) Pub Date : 2023-12-05 Theodore A. Slotkin
Abstract not available
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Preventive and therapeutic effects of azithromycin on acrylamide-induced neurotoxicity in rats Neurotoxicology (IF 3.4) Pub Date : 2023-12-02 Homa Fazeli Kakhki, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Mahmoud Reza Heidari, Hossein Hosseinzadeh
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α-Pyrrolidinononanophenone derivatives induce differentiated SH-SY5Y neuroblastoma cell apoptosis via reduction of antioxidant capacity: Involvement of NO depletion and inactivation of Nrf2/HO1 signaling pathway Neurotoxicology (IF 3.4) Pub Date : 2023-11-30 Yuji Sakai, Daisuke Egawa, Junta Hattori, Yoshifumi Morikawa, Koichi Suenami, Tomohiro Takayama, Atsushi Nagai, Tomomi Michiue, Akira Ikari, Toshiyuki Matsunaga
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Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice Neurotoxicology (IF 3.4) Pub Date : 2023-11-21 Brittany L. Smith, Ally Hassler, Kelsey R. Lloyd, Teresa M. Reyes
Within the national opioid epidemic, there has been an increase in the number of infants exposed to opioids in utero. Additionally, opioid agonist medications are the standard of care for women with opioid use disorder during pregnancy. Buprenorphine (BUP), a partial µ -opioid receptor agonist, has been successful in improving gestational and neonatal outcomes. However, in utero exposure has been linked
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Long-term LPS systemic administration leads to memory impairment and disturbance in astrocytic homeostasis Neurotoxicology (IF 3.4) Pub Date : 2023-11-23 Gabriel Henrique Schirmbeck, Marina Seady, Fernanda Telles Fróes, Jéssica Taday, Carollina Da Ré, Jéssica Maria Souza, Carlos Alberto Gonçalves, Marina Concli Leite
Dementia is the most prevalent neurodegenerative disorder, characterized by progressive loss of memory and cognitive function. Inflammation is a major aspect in the progression of brain disorders, and inflammatory events have been associated with accelerated deterioration of cognitive function. In the present work, we investigated the impact of low-grade repeated inflammation stimuli induced by lipopolysaccharide
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Evaluating the toxic mechanism of 1,2-diacetylbenzene in neural cells/tissues: The favorable impact of silibinin Neurotoxicology (IF 3.4) Pub Date : 2023-11-18 Li-Yu Fay, Jun-Yi Chien, Ching-Feng Weng, Huai-Sheng Kuo, Dann-Ying Liou, Wei-Hao Weng, Chi-Hung Lin, Ya-Tzu Chen, Wen-Hung Huang, Wen-Cheng Huang, May-Jywan Tsai, Henrich Cheng
1,2-diacetylbenzene (1,2-DAB) is a neurotoxic component of aromatic solvents commonly used in industrial applications that induces neuropathological changes in animals. This study unraveled the toxic impact of 1,2-DAB in nerve tissues, explant cultures, and neuron-glial cultures, and explored whether herbal products can mitigate its toxicity. The effects of DAB on axonal transport were studied in retinal
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Melatonin enhances the restoration of neurological impairments and cognitive deficits during drug withdrawal in methamphetamine-induced toxicity and endoplasmic reticulum stress in rats Neurotoxicology (IF 3.4) Pub Date : 2023-11-17 Pongphat Komlao, Natcharee Kraiwattanapirom, Kitipong Promyo, Zaw Myo Hein, Banthit Chetsawang
Methamphetamine (METH) is a psychostimulant with a very high addiction rate. Prolonged use of METH has been observed as one of the root causes of neurotoxicity. Melatonin (Mel) has been found to have a significant role in METH-induced neurotoxicity. This study aimed to investigate the restorative effect of Mel on behavioral flexibility in METH-induced cognitive deficits. Male Sprague-Dawley rats were
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Kynurenine attenuates mitochondrial depolarization and neuronal cell death induced by rotenone exposure independently of AhR-mediated parkin induction in SH-SY5Y differentiated cells Neurotoxicology (IF 3.4) Pub Date : 2023-11-17 Rosario García-Aguilar, Arturo Ortega, Esther López-Bayghen, Leticia Ramírez-Martínez, Ada Rodriguez-Campuzano, Fátima Murillo-González, Guillermo Elizondo, Libia Vega
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A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior Neurotoxicology (IF 3.4) Pub Date : 2023-11-10 Miao Zhang, Xueyan Gu, Liu Wu, Nannan Wan, Yu Liu, Zaijun Xin, Tianbing Chen, Shuai Liu, Mingqi Li, Mi Deng, Qiyu Wang
Perfluorooctane sulfonic acid (PFOS) is one of the main residual environmental pollutants that threaten human health. PFOS exposure is positively correlated with the prevalence of attention deficit hyperactivity disorder (ADHD); however, the underlying mechanism is unknown. Given that dopamine (DA) is a crucial target for PFOS and that its dysfunction is a key role in ADHD development, it is speculated
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Repeated toluene and cyclohexane inhalation produces differential effects on HPA and HPT axes in adolescent male rats Neurotoxicology (IF 3.4) Pub Date : 2023-11-08 P. Soberanes-Chávez, P. de Gortari, C. García-Luna, SL Cruz
Misused volatile solvents typically contain toluene (TOL) as the main psychoactive ingredient. Cyclohexane (CHX) can also be present and is considered a safer alternative. Solvent misuse often occurs at early stages of life, leading to permanent neurobehavioral impairment and growth retardation. However, a comprehensive examination of the effects of TOL and CHX on stress regulation and energy balance
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Friedelin and Glutinol induce neuroprotection against ethanol induced neurotoxicity in pup’s brain through reduction of TNF-α, NF-kB, caspase-3 and PARP-1 Neurotoxicology (IF 3.4) Pub Date : 2023-11-07 Marva Sandhu, Hafiz Muhammad Irfan, Laiba Arshad, Aman Ullah, Shahid Ali Shah, Hussain Ali
Ethanol administration triggers an inflammatory response that leads to a complex series of immune responses including the release of an excessive amount of inflammatory mediators particularly tumor necrosis factor (TNF-α) and nuclear factor-kB (NF-KB) which produce a large amount of reactive oxygen species. The inflammatory-induced cytotoxicity is increased when the PI3-kinase/Akt pathway is inhibited
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An adverse outcome pathway for chemical-induced Parkinson’s disease: Calcium is key Neurotoxicology (IF 3.4) Pub Date : 2023-11-04 Julia J. Meerman, Juliette Legler, Aldert H. Piersma, Remco H.S. Westerink, Harm J. Heusinkveld
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Maternal exposure to polystyrene microplastics impairs social behavior in mouse offspring with a potential neurotoxicity Neurotoxicology (IF 3.4) Pub Date : 2023-11-01 Yun Hee So, Hyun Seung Shin, Seung Hyun Lee, Ha Jung Moon, Hyeon Jung Jang, Eun-Hee Lee, Eui-Man Jung
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Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis Neurotoxicology (IF 3.4) Pub Date : 2023-10-31 William P. Marinello, Sagi Enicole A. Gillera, Lynn Huang, John Rollman, David M. Reif, Heather B. Patisaul
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Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling Neurotoxicology (IF 3.4) Pub Date : 2023-10-26 Vanessa Valéria Miron, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Nathieli Bianchin Bottari, Jucimara Baldissarelli, Karine Paula Reichert, Aniélen Dutra da Silva, Milagros Fanny Vera Castro, Loren Borba de Jesus, Marcylene Vieira da Silveira, Tais Vidal Palma, Vera Maria Morsch, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger
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Nano polystyrene induced changes in anxiety and learning behaviour are mediated through oxidative stress and gene disturbance in mouse brain regions Neurotoxicology (IF 3.4) Pub Date : 2023-10-20 Anju Sharma, Manjyot Kaur, Kirti Sharma, Suresh kumar Bunkar, Placheril John, Pradeep Bhatnagar
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Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays Neurotoxicology (IF 3.4) Pub Date : 2023-10-20 Emily M. Pitzer, Timothy J. Shafer, David W. Herr
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Net effects explains the benefits to children from maternal fish consumption despite methylmercury in fish Neurotoxicology (IF 3.4) Pub Date : 2023-10-20 Philip Spiller, Edwin van Wijngaarden, Heather R. Adams, J.J. Strain, Emeir M. McSorley, Maria S. Mulhern, Marie C. Conway, Allison J. Yeates, Clark Carrington, P. Michael Bolger, Kara M. Morgan, Caroline M. Taylor, Nicholas V.C. Ralston, Michael A. Crawford, Joseph R. Hibbeln, J. Thomas Brenna, Gary J. Myers
In 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concern that the methylmercury content might harm their children’s neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food
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KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2 Neurotoxicology (IF 3.4) Pub Date : 2023-10-17 Helena Korres de Paula, Tanzy M. Love, Daniela Pineda, Gene E. Watson, Sally W. Thurston, Alison J. Yeates, Maria S. Mulhern, Emeir M. McSorley, J.J. Strain, Conrad F. Shamlaye, G.J. Myers, Matthew D. Rand, Edwin van Wijngaarden, Karin Broberg
Background Humans differ in the metabolism of the neurotoxicant methyl mercury (MeHg). This variation may be partially due to variation in genes encoding the transcription factor Nuclear factor E2-related factor 2 (NRF2) and its negative regulator Kelch-like ECH-Associated Protein 1 (KEAP1), which regulate glutathione and related transporter and antioxidant proteins that play a role in the metabolism
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Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2 Neurotoxicology (IF 3.4) Pub Date : 2023-10-11 Jonathan K. Klus, Sally W. Thurston, Gary J. Myers, Gene E. Watson, Matthew D. Rand, Tanzy M. Love, Alison J. Yeates, Maria S. Mulhern, Emeir M. McSorley, J.J. Strain, Conrad F. Shamlaye, Edwin van Wijngaarden
Background Consumption of fish yields many nutritional benefits, but also results in exposure to methylmercury (MeHg). The developing brain is known to be particularly susceptible to MeHg toxicity in high doses. However, the potential impact of low-level environmental exposure from fish consumption on children’s neurodevelopment remains unclear. Methods We investigated postnatal MeHg exposure at 7
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Quantitative proteomics reveals the neurotoxicity of trimethyltin chloride on mitochondria in the hippocampus of mice Neurotoxicology (IF 3.4) Pub Date : 2023-10-13 Zhenzhong Liu, Li Wang, Yue Wang, Siya Wu, Caiting Peng, Yu Wang, Ming Huang, Li Che, Rongjing Sun, Xi Zhao, Zuo Du, Wenhu Liu
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Harmaline toxicity on dorsal striatal neurons and its role in tremor Neurotoxicology (IF 3.4) Pub Date : 2023-10-13 Xiping Zhan, Ly V. Do, Li Zou, Ryan Shu Zhan, Michael Jones, Saba Nawaz, Kebreten Manaye
Harmaline is one of the β-carboline derivative compounds that is widely distributed in the food chain and human tissues. Harmine, a dehydrogenated form of harmaline, appeared to have a higher concentration in the brain, and appeared to be elevated in essential tremor (ET) and Parkinson’s disease. Exogenous harmaline exposure in high concentration has myriad consequences, including inducing tremor,
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Fish consumption and its lipid modifying effects – A review of intervention studies Neurotoxicology (IF 3.4) Pub Date : 2023-10-11 James E. McMullan, Alison J. Yeates, Philip J. Allsopp, Maria S. Mulhern, J.J. Strain, Edwin van Wijngaarden, Gary J. Myers, Emelyn Shroff, Conrad F. Shamlaye, Emeir M. McSorley
Fish is an important source of nutrients, particularly the long chain n-3 polyunsaturated fatty acids (n-3 PUFAs). The incorporation of fish into the diet has been shown to have several health benefits, including lowering the risk of cardiovascular disease (CVD). Elevated plasma lipids are one of the main modifiable risk factors contributing to CVD and may be partly mediated by n-3 PUFAs. Although
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Childhood exposure to pyrethroids and neurodevelopment in Canadian preschoolers Neurotoxicology (IF 3.4) Pub Date : 2023-10-05 Patrick Ntantu Nkinsa, Mandy Fisher, Gina Muckle, Mireille Guay, Tye E. Arbuckle, William Fraser, Khrista Boylan, Linda Booij, Mark Walker, Maryse F. Bouchard
Background Pyrethroid insecticides are used both residentially and agriculturally and their toxicity targets the nervous system of insects. They might also interfere with development and function of the human brain. A few epidemiological studies suggest that exposure to pyrethroids may be associated with neurobehavioral problems in children but there is little data on potential associations with cognitive
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Synchrotron X-ray methods in the study of mercury neurotoxicology Neurotoxicology (IF 3.4) Pub Date : 2023-10-05 Ashley K. James, Bogdan F. Popescu, Monica Weng, Gary J. Myers, John L. O’Donoghue, Gene E. Watson, Ingrid J. Pickering, Graham N. George
In situ methods are valuable in all fields of research. In toxicology, the importance of dose is well known, elevating the need for in situ techniques to measure levels of toxicants and their byproducts in precise anatomically identifiable locations. More recently, additional emphasis has been placed on the value of techniques which can detect chemical form or speciation, which is equally important
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Comparing the association between heavy metals and cognitive status and depression in miners and non-miners: A study from southeast of Iran Neurotoxicology (IF 3.4) Pub Date : 2023-09-30 Narjes Soltani, Tabandeh Sadeghi, Parvin Khalili, Mohammad Reza Mahmoodi, Majid Saadloo, Mohammad Reza Baneshi, Soghra Akbari Chermahini, Ali Shamsizade
Heavy metal toxicity is a major public health crisis worldwide, especially in mining environments. The association between chronic heavy metals exposure and cognitive impairment has not been studied broadly in adults and mining fields. This study aimed to compare the association between arsenic (As), lead (Pb), and copper (Cu) concentration in blood and cognitive status and depression in copper miners
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Developmental organophosphate flame retardant exposure disrupts adult hippocampal neurogenesis in Wistar rats Neurotoxicology (IF 3.4) Pub Date : 2023-09-30 Andrew J. Newell, Heather B. Patisaul
Organophosphate flame retardant (OPFR) contamination is ubiquitous and bio-monitoring studies have shown that human exposure is widespread and may be unavoidable. OPFRs bear structural similarities to known neurotoxicants such as organophosphate insecticides and have been shown to have both endocrine disrupting and developmental neurotoxic effects. The perinatal period in rodents represents a critical
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Corrigendum to “Lambda-cyhalothrin enhances inflammation in nigrostriatal region in rats: Regulatory role of NF-κβ and JAK-STAT signaling” [NeuroToxicology 96 (2023) 101–117] Neurotoxicology (IF 3.4) Pub Date : 2023-09-27 Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khanna
Abstract not available
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Corrigendum to “Pharmacological evaluation of bromelain in mouse model of Alzheimer’s disease” [NeuroToxicology 90 (2022) 19–34] Neurotoxicology (IF 3.4) Pub Date : 2023-09-21 Rakesh Kumar, Rajan Kumar, Neha Sharma, Navneet Khurana, Sachin Kumar Singh, Saurabh Satija, Meenu Mehta, Manish Vyas
Abstract not available
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Linalool attenuates hypothalamus proteome disturbance facilitated by methamphetamine induced neurotoxicity in rats Neurotoxicology (IF 3.4) Pub Date : 2023-09-18 Khaled M.M. Koriem, Sara W.B. El-Qady