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Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-11-28 Rachel Membreno,Kelsey R Thomas,Amanda T Calcetas,Lauren Edwards,Maria Bordyug,Maya Showell,Morgan Stanfill,Einat K Brenner,Kayla S Walker,Lindsay J Rotblatt,Adam M Brickman,Emily C Edmonds,Katherine J Bangen,
INTRODUCTION White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or total WMH; less is known about associations of regional WMHs and cognitive abilities among older adults without dementia. METHODS A total of 610 older
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Alzheimer Disease: A New Beginning in Therapeutics. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-11-28 Lawrence S Honig
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Proteomic Analysis Reveals Potential Exosomal Biomarkers in Patients With Sporadic Alzheimer Disease. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-11-28 Konstanze Plaschke,Jürgen Kopitz,Johannes Gebert,Nadine D Wolf,Robert Christian Wolf
BACKGROUND Despite substantial progress made in the past decades, the pathogenesis of sporadic Alzheimer disease (sAD) and related biological markers of the disease are still controversially discussed. Cerebrospinal fluid and functional brain imaging markers have been established to support the clinical diagnosis of sAD. Yet, due to the invasiveness of such diagnostics, less burdensome markers have
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Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-11-28 Youssef Razouqi,Ihssane El Bouchikhi,Hassan El-Abid,Soukayna Baammi,Ayoub Nedbour,Ahmed Omar Touhami Ahami,Achraf El Allali,Laila Bouguenouch
Alzheimer disease (AD) is a major public health concern worldwide. It is a severe neurodegenerative disease that primarily affects the elderly and causes significant brain cell death. According to the most complete scientific research, the APOE gene, which encodes the APOE protein, maybe the key to identifying the likely cause of delayed AD. The development of plaques and tangles, as well as increased
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A Longitudinal Evaluation of the Pattern of Social Cognition Impairment in Brazilians With Alzheimer's Disease. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-11-02 Tatiana Teresa Belfort Almeida Dos Santos,Marcela Moreira Lima Nogueira,Isabel Barbeito Lacerda,Michelle Brandt,Aline Tavares de Lucena,Rogeria Rangel,Julia Gaigher,Felipe Oliveira,Marcia Cristina Nascimento Dourado
BACKGROUND Social cognition (SC) impairments contribute to the dependence of people with Alzheimer disease (AD), influencing their functional disability and the burden on family members and caregivers. Our objective was to longitudinally investigate the relationship between SC and cognitive and clinical variables in persons with AD and their caregivers. We also evaluated the different SC predictors
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Perspectives From Black and White Participants and Care Partners on Return of Amyloid and Tau PET Imaging and Other Research Results. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-10-30 Annalise Rahman-Filipiak,Mary Lesniak,Shima Sadaghiyani,Scott Roberts,Peter Lichtenberg,Benjamin M Hampstead
PURPOSE Alzheimer disease (AD) biomarker testing is now common in research and approaching clinical translation. Disclosure protocols must be informed by diverse participants' perspectives on if/how the information would be useful. METHODS This study utilized semistructured interviews assessing interest in receiving positron emission tomography (PET) amyloid and tau results, as well as perceived risks
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Mild Cognitive Impairment Subtype Performance in Comparison to Healthy Older Controls on the NIH Toolbox and Cogstate. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-10-20 Sarah Garcia,Robert L Askew,Voyko Kavcic,Sarah Shair,Arijit K Bhaumik,Edna Rose,Stephen Campbell,Nicolas May,Benjamin M Hampstead,Hiroko H Dodge,Judith L Heidebrink,Henry L Paulson,Bruno Giordani
BACKGROUND Early detection is necessary for the treatment of dementia. Computerized testing has become more widely used in clinical trials; however, it is unclear how sensitive these measures are to early signs of neurodegeneration. We investigated the use of the NIH Toolbox-Cognition (NIHTB-CB) and Cogstate-Brief computerized neuropsychological batteries in the identification of mild cognitive impairment
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Aspects of Rest-Activity Rhythms Associated With Behavioral and Psychological Symptoms in Moderate and Severe Dementia: Results of a Cross-sectional Analysis. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-10-13 Daiki Ishimaru,Hiroyuki Tanaka,Yuma Nagata,Yasuhiro Ogawa,Keita Fukuhara,Takashi Nishikawa
OBJECTIVE Disturbances in rest-activity rhythms (RAR) are commonly observed in patients with dementia; however, the influence thereof on behavioral and psychological symptoms of dementia (BPSD) remains unexplored. This study aimed to determine whether there is an association between RAR and BPSD among patients with moderate and severe dementia. METHODS RAR analyses of 64 participants were performed
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Anticipated Psychological or Behavioral Reactions to Learning Alzheimer Biomarker Results: Associations With Contextual Factors. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-10-12 Lindsay R Clark,Claire M Erickson,Nathaniel A Chin,Kristin E Basche,Erin M Jonaitis,Fred B Ketchum,Carey E Gleason
BACKGROUND As Alzheimer disease (AD) biomarker testing becomes more widely available, adults may opt to learn results. Considering potential reactions to learning biomarker results can guide prebiomarker and postbiomarker testing education and counseling programs. METHODS Cognitively healthy adults enrolled in observational Alzheimer research responded to a telephone survey about learning AD risk information
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Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-10-02 Aline S G G Conceição,Lívea F G Sant Ana,Guilherme P Mattar,Maria de Fátima R Silva,Andressa R Ramos,Alexandra M Oliveira,Claudia L Carvalho,Octavio R Gonçalves,Bruna L R Varotto,Luana D Martinez,Vinícius Leduc,Luciana M Fonseca,Orestes V Forlenza
BACKGROUND Atypical aging in Down syndrome (DS) is associated with neuropathological characteristics consistent with Alzheimer disease. Gait abnormalities have been shown to be associated with an increased risk of dementia for the general population. The aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with DS. METHODS
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A Visual Analog Scale for Self-Reported Quality of Life: A Comparison of VAS and QoL-AD in Older Adults. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-09-22 Elizabeth Redford,Sabine Heuer
PURPOSE People with dementia (PWD) are one of the fastest-growing clinical populations for speech-language pathologists. Self-reported quality of life (QoL) assessments are critical patient-reported outcome measures that align with person-centered care principles. However, proxy-reporting is most often used due to assumptions that PWD cannot provide reliable self-report. Visual analog scales (VASs)
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Gender, Pain, and Function Associated With Physical Activity After Hospitalization in Persons Living With Dementia. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-09-20 Ashley Kuzmik,Marie Boltz,Barbara Resnick,Brittany F Drazich,James E Galvin
BACKGROUND The purpose of this study was to identify factors that are associated with physical activity after hospitalization in persons living with dementia. METHODS Multiple linear regressions were conducted to test factors associated with objective activity levels (sedentary, low, moderate, and vigorous) among 244 patients living with dementia from a randomized controlled trial. RESULTS Within 48
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Virtual Assessment as a Way to Reduce Help-seeking Barriers in Older Adults With Subjective Cognitive Decline. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-09-19 Michael R Kann,Peter J Zeiger,Sandra J Rizer,Stephanie Cosentino,Martina Azar
Subjective cognitive decline (SCD), a potential early marker for neurodegenerative disease such as Alzheimer's disease, is common among older adults. Although it is often regarded as a personal health concern, most individuals with SCD do not seek help from a health care professional. Help-seeking (HS) is a complex, individualized process with significant life-course implications, and older adults
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Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-09-13 Carla R Schubert,Adam J Paulsen,A Alex Pinto,Richard J Chappell,Yanjun Chen,Luigi Ferrucci,Laura M Hancock,Karen J Cruickshanks,Natascha Merten
AIM To determine whether exposure to neurotoxins in midlife is associated with changes in blood-based biomarkers of neurodegeneration and Alzheimer disease pathology. METHODS Blood cadmium, lead, neurofilament light (NfL) chain, total tau (TTau), and amyloid beta (Aβ) 40 and Aβ42 concentrations were measured in 1516 participants in the Beaver Dam Offspring Study. Linear mixed-effect models were used
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A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-09-11 Marwan N Sabbagh,Philip Mathew,Alan Blau
BACKGROUND A once-weekly donepezil transdermal delivery system (TDS; Adlarity; Corium, LLC) is indicated for the treatment of mild, moderate, and severe dementia of the Alzheimer type. METHODS In this placebo-controlled, randomized, double-blind phase 1 trial, healthy volunteers aged 40 years or older were randomized to receive a placebo and donepezil TDS and were evaluated for the primary endpoints
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A Pilot Randomized Trial of a Purposeful and Stimulating Volunteer Opportunity: Program Satisfaction and Potential Impacts on Perceived Cognitive Change in a Neurologically Mixed Sample of Older Adults. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-08-24 John D Piette,Benjamin M Hampstead,Nicolle Marinec,Jenny Chen,J Scott Roberts
BACKGROUND Purposeful social interactions are important for healthy aging. We conducted a pilot trial of SPEAK! (Seniors Promoting English Acquisition and Knowledge), an intervention providing older volunteers with a safe, accessible opportunity to converse via webcam with English-language learners. METHODS A neurologically mixed sample of older adults was randomized to 8 weekly, webcam conversations
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Predictors of Cognitive Change in Parkinson Disease: A 2-year Follow-up Study. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-08-22 Carmen Gasca-Salas,Sarah Duff-Canning,Eric McArthur,Melissa J Armstrong,Susan Fox,Christopher A Meaney,David F Tang-Wai,David Gill,Paul J Eslinger,Cindy Zadikoff,Fred J Marshall,Mark Mapstone,Kelvin L Chou,Carol Persad,Irene Litvan,Benjamin T Mast,Adam T Gerstenecker,Sandra Weintraub,Connie Marras
BACKGROUND Mild cognitive impairment is common in Parkinson disease (PD-MCI). However, instability in this clinical diagnosis and variability in rates of progression to dementia raises questions regarding its utility for longitudinal tracking and prediction of cognitive change in PD. We examined baseline neuropsychological test and cognitive diagnosis predictors of cognitive change in PD. METHODS Persons
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Utility of amyloid PET Imaging in a Memory Clinic. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-08-11 Alexandra Pletnikova,Hamid R Okhravi,Nimra Jamil,Mackenzie Kirby,Constantine G Lyketsos,Esther S Oh
There is greater interest in amyloid biomarker for the diagnosis of Alzheimer disease (AD) with the recent Food and Drug Administration approval of amyloid-targeted therapy. The goal of this study was to assess the clinical utility of amyloid positron emission tomography (PET) in clinically ambiguous cases of cognitive impairment by examining outcomes of patients enrolled in the Imaging Dementia-Evidence
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Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-08-02 Michael B Prough,Andrew Zaman,Laura J Caywood,Jason E Clouse,Sharlene D Herington,Susan H Slifer,Daniel A Dorfsman,Larry A Adams,Reneé A Laux,Yeunjoo E Song,Audrey Lynn,Denise Fuzzell,Sarada L Fuzzell,Sherri D Miller,Kristy Miskimen,Leighanne R Main,Michael D Osterman,Paula Ogrocki,Alan J Lerner,Jeffery M Vance,Jonathan L Haines,William K Scott,Margaret Pericak-Vance,Michael L Cuccaro
BACKGROUND Verbal and visuospatial memory impairments are common to Alzheimer disease and Related Dementias (ADRD), but the patterns of decline in these domains may reflect genetic and lifestyle influences. The latter may be pertinent to populations such as the Amish who have unique lifestyle experiences. METHODS Our data set included 420 Amish and 401 CERAD individuals. Sex-adjusted, age-adjusted
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Education as a Moderator of Help Seeking Behavior in Subjective Cognitive Decline. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-31 Martina Azar,Silvia Chapman,Jillian Joyce,Maria Schultheis,Zoe Zhang,Leah Waltrip,Shaina Shagalow,Peter Zeiger,Preeti Sunderaraman,Stephanie Cosentino
OBJECTIVE Disparities in Alzheimer disease (AD) and differences in help seeking (HS) across sociodemographic groups warrant public health concern. Research addressing such disparities must shift toward the earliest clinical manifestations of AD to optimize diagnosis, intervention and care planning. Subjective cognitive decline (SCD), a risk state for AD, provides an important context in which to examine
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Can Depressive Symptomatology at Diagnosis Predict Cognitive and Functional Decline Over 1 Year in Rural Canadian Patients With Dementia? Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-31 Shuang Cai,Andrew Kirk,Chandima Karunanayake,Megan E O'Connell,Debra Morgan
INTRODUCTION Depressive symptomatology is often associated with the onset of dementia, although the exact form and directionality of this association is still unclear. The aim of this study is to investigate whether depressive symptomatology at the time of dementia diagnosis was predictive of cognitive, functional, and behavioral decline over 1 year. METHODS In a Rural and Remote Memory Clinic, 375
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Impaired Emotion Recognition: A Potential Marker for Social Behavioral Problems in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease? Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-24 Fijanne Strijkert,Rients B Huitema,Barbara C van Munster,Jacoba M Spikman
OBJECTIVE Emotion recognition, an important aspect of social cognition, can be impaired already in early Alzheimer disease dementia and amnestic mild cognitive impairment (aMCI) and may underly social behavioral changes, which can increase caregiver burden. However, social behavior is difficult to assess in outpatient settings. We evaluated whether impaired emotion recognition is related to proxy-rated
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Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-24 Elyse Couch,Miriam T Ashford,Wenhan Zhang,Matthew Prina
BACKGROUND Positron emission tomography (PET) scans for amyloid-β can aid in the early and accurate detection of Alzheimer disease. The results of amyloid PET scans could help people with cognitive impairment and caregivers better understand their diagnosis; however, there are concerns that they could also cause psychological harm. METHODS A systematic review of psychosocial and behavioral quantitative
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Meta-Analysis of Animal Fluency Performance in Amnestic Mild Cognitive Impairment and Cognitively Unimpaired Older Adults. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-24 Vivek Sharma,Michael Malek-Ahmadi
Animal fluency is a commonly used neuropsychological measure that is used in the diagnosis of amnestic mild cognitive impairment (aMCI) and Alzheimer disease. Although most individuals with aMCI have clinically normal scores on this test, several studies have shown that aMCI individuals' performance is significantly lower than that of cognitively unimpaired (CU) individuals. The aim of this meta-analysis
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Dementia Prevalence and Risk Factors: Data From Rural Tanzania. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-10 Caitlin Roe,Ssenku Safic,Lwitiko Mwaipopo,Catherine L Dotchin,Joanna Klaptocz,William Gray,Marcyella Joseph,Aimee Spector,Sarah Urasa,Richard W Walker
OBJECTIVES The burden of dementia is increasing in sub-Saharan Africa (SSA), but there are limited epidemiological data on dementia in SSA. This study investigated the prevalence and associations of dementia in older adults (less than 60 y) attending the outpatient department of Mount Meru Hospital in Tanzania. METHODS This one-phase cross-sectional study screened a sample using the Identification
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To the Editor and Readership of Alzheimer Disease and Associated Disorders. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-07-05 Laura M Tidmore,Grant H Skrepnek
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Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-06-26 Haythum O Tayeb,Nadeem S Butt,Roaa Khallaf,Bassam Yahghmour,Mohammed A Basheikh,Sultan H Alamri,Abrar O Baduwailan,Faten Alzaben,Haifa K Abdulghaffar,Harold G Koenig
BACKGROUND The burden of behavioral and psychiatric symptoms in dementia (BPSD) has not been characterized in Saudi patients with Alzheimer disease (AD). Moreover, the Saudi version of the Neuropsychiatric Inventory (SNPI) has not been validated. OBJECTIVES The purpose of this study was to validate the SNPI and describe frequency and determinants of BPSD in Saudi AD patients. METHODS The SNPI and BEHAVE-AD
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A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-06-22 Yoko Sugimura,Toru Baba,Michinori Ezura,Akio Kikuchi,Takafumi Hasegawa,Isao Nagano,Kyoko Suzuki,Atsushi Takeda
Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a variety of higher cortical dysfunction. Predicting background pathology of corticobasal syndrome is rather challenging; however, clinical and neuroimaging findings may provide a clue to its etiopathological origin. Visuospatial dysfunction of posterior cortical atrophy and logopenic-type language impairment
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Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-06-21 Maria Alice Tourinho Baptista,Isabel Barbeito Lacerda,Tatiana Belfort,Marcela Moreira Lima Nogueira,Felipe de Oliveira Silva,Marcia Cristina Nascimento Dourado
INTRODUCTION Executive function (EF) involves a general cognitive process linked to strategic organization and control of complex goal-oriented tasks. In young-onset dementia (YOD), especially Alzheimer's disease, the symptoms that stand out in the initial stage are deficits in attention, visual-spatial function, praxis, and language. The present study aims to investigate what components of EF differ
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Large Discrepancies in Dementia Mortality Reported in Vital Statistics: The Need for Improved Data to Inform Policy. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-06-08 Tim Adair,Hang Li,Jeromey Temple,Kaarin J Anstey
PURPOSE There is limited understanding of the intercountry comparability of dementia mortality data. This study compares reported dementia mortality in national vital statistics between countries and over time. In countries with low dementia reporting, this study identifies other causes to which dementia may be misclassified. METHODS Using the World Health Organization (WHO) Mortality Database, we
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CSF1R-related Adult-onset Leukoencephalopathy: The First Reported Case in Spain. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-05-15 Cristina Moreno Loscertales,Paula Canasto Jiménez,Mario Bautista Lacambra,Luisa Tique Rojas,Silvia Izquierdo Álvarez,Eugenia Marta Moreno
Colony-stimulating factor 1 receptor-related adult-onset leukoencephalopathy is a primary microgliopathy characterized by a complex phenotype, which can be easily misdiagnosed with other leukoencephalopathy and neurodegenerative diseases such as frontotemporal dementia. It is estimated to be the most common adult-onset leukodystrophy. Here, we report the case of a 67-year-old man with a history of
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Remuneration and Recruitment of Study Participants for AD Cohort Studies From the General Public and From Minority Communities Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-05-08 Matthew Gabel, Andrea Denny, Jorge Llibre-Guerra, John C. Morris, Jennifer Phillips, Ashish Vaidyanathan
Introduction: Offering remuneration for participation in studies of aging and Alzheimer Disease (AD) may improve recruitment, particularly among minoritized and low-income groups. But remuneration may also raise ethical problems and reduce altruistic motivations for participation. Methods: A nationally representative sample of Americans (N=2030) with large (N=500) Black and Hispanic oversamples was
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Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-05-08 Valérie J van Hezik-Wester,Ron L H Handels,Claire A G Wolfs,Tim A Kanters
INTRODUCTION The objective is to estimate the caregiver burden in terms of informal care time, health-related quality of life (HRQoL), and societal costs by disease severity (mild, moderate, or severe) and living situation (community-dwelling or institutionalized) of persons with AD (PwAD); and PwAD HRQoL. METHODS Caregivers were recruited through an online panel provider in the Netherlands. The survey
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An Indian Young-onset Dementia With Parkinsonism With Double Heterozygous Mutations in ABCA7 and PRKN Identified Through Whole-exome Sequencing. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-05-08 Dipanwita Sadhukhan,Aishwarya Mallick,Smriti Mishra,Adreesh Mukherjee,Atanu Biswas,Subhra P Hui,Arindam Biswas
Alzheimer disease and Parkinson disease dementia are the 2 most common neurodegenerative diseases have substantial overlap in pathologic, genetic, and clinical manifestation and complex in nature. Here, for the first time, we report an Indian female young patient who presented with clinical manifestation of both Alzheimer disease and Parkinsonism, including dystonia with rapid disease progression.
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Remuneration and Recruitment of Study Participants for AD Cohort Studies From the General Public and From Minority Communities. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-05-08 Matthew Gabel,Andrea Denny,Jorge Llibre-Guerra,John C Morris,Jennifer Phillips,Ashish Vaidyanathan
INTRODUCTION Offering remuneration for participation in studies of aging and Alzheimer Disease (AD) may improve recruitment, particularly among minoritized and low-income groups. But remuneration may also raise ethical problems and reduce altruistic motivations for participation. METHODS A nationally representative sample of Americans (N=2030) with large (N=500) Black and Hispanic oversamples was asked
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Trends in Alzheimer Disease Mortality Among American Indian and Alaska Native People Between 2011 and 2019 Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-04-28 Solmaz Amiri, Luohua Jiang, Spero M. Manson, Dedra S. Buchwald
Purpose: The number of American Indian and Alaska Native (AI/AN) people living with dementia is expected to increase 5-fold by 2060. Social determinants of health may explain disparities in the incidence of Alzheimer disease (AD) but remain largely overlooked. Methods: We examined the time trend of AD mortality rates and associations of the percentage of AI/ANs, density of primary care physicians
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Cognitive Impairment and the Associated Factors Among Older People in Rural Central Tanzania Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-04-24 Golden M. Masika, Azan Nyundo, Laidi Msisiri
Aim: This study examined the profile of cognitive impairment and associated factors among older people in rural central Tanzania. Methods: We conducted a cross-sectional study involving 462 community-dwelling older adults. We performed cognitive, psychosocial, and clinical assessments and face-to-face interviews with all older adults. Descriptive, bivariate and multivariate linear regression analyses
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Behavioral and Brain Correlates of Emotional Distress in Older Adults During COVID-19 Quarantine Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-04-01 Ori Benari, Ramit Ravona Springer, Ganit Almog, Iscka Yore, Maya Zadok, Hung-Mo Lin, Yuxia Ouyang, Mary Sano, Barbara B. Bendlin, Abigail Livny, Anthony Heymann, Michal Schnaider Beeri
COVID-19 led to unprecedented lockdowns and changes in older adults’ lives, especially those with type 2 diabetes who have high risk of complications and mortality. We investigated the associations of cognitive and motor function and gray matter volumes (GMVs) with COVID-19 lockdown-related emotional distress of type 2 diabetes older adults, participating in the Israel Diabetes and Cognitive Decline
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Behavioral and Brain Correlates of Emotional Distress in Older Adults During COVID-19 Quarantine. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-04-01 Ori Benari,Ramit Ravona Springer,Ganit Almog,Iscka Yore,Maya Zadok,Hung-Mo Lin,Yuxia Ouyang,Mary Sano,Barbara B Bendlin,Abigail Livny,Anthony Heymann,Michal Schnaider Beeri
COVID-19 led to unprecedented lockdowns and changes in older adults' lives, especially those with type 2 diabetes who have high risk of complications and mortality. We investigated the associations of cognitive and motor function and gray matter volumes (GMVs) with COVID-19 lockdown-related emotional distress of type 2 diabetes older adults, participating in the Israel Diabetes and Cognitive Decline
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Assessing how Age, Sex, Race, and Education Affect the Relationships Between Cognitive Domains and Odor Identification Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-03-23 Selena Zhong, Kristen E. Wroblewski, Edward O. Laumann, Martha K. McClintock, Jayant M. Pinto
Background: The associations between cognitive domains and odor identification are well established, but how sociodemographic variables affect these relationships is less clear. Purpose: Using the survey-adapted Montreal Cognitive Assessment instrument (MoCA-SA), we assess how age, sex, race, and education shape these relationships. Methods: We first used cluster analysis and multidimensional scaling
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The Impact of Episodes of Lucidity on People Living With Dementia and Their Caregivers: A Case Report Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-03-20 Clark Benson, Jess Fehland, Meghan Botsch, Laura Block, Andrea Gilmore-Bykovskyi
People living with dementia (PLWD) may experience the episodes of lucidity (ELs), defined as a sudden return of abilities presumed to have been lost and presenting as meaningful communication and connection. Early research on ELs in advanced disease stages suggests these are predominantly positive events. This case report draws from 1 outlier case from a descriptive qualitative study on caregivers
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A Virtual Photovoice Study of Older African Americans Perceptions of Neurovascular Clinical Trials Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-03-13 Ashley R. Shaw, Saria Lofton, Eric D. Vidoni
Background: Alzheimer disease (AD) poses a major public health crisis, especially among African Americans (AAs) who are up to 3 times more likely to develop AD compared with non-Hispanic Whites. Moreover, cardiovascular risk factors represent a precursor to cognitive decline, which contributes to racial/ethnic disparities seen within AD. Despite these disparities, AAs are underrepresented in neurovascular
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Delirium and Behavioral Symptoms in Persons With Dementia at Hospital Admission: Mediating Factors Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-03-13 Marie Boltz, Ashley Kuzmik, Barbara Resnick, Rhonda BeLue, Ying-Ling Jao, Anju Paudel, Liza Behrens, Doug Leslie, Liron Sinvani, James E. Galvin
Background: Hospitalized persons with dementia are at risk of delirium with behavioral symptoms, predisposing them to a higher rate of complications and caregiver distress. The purpose of this study was to examine the relationship between delirium severity in patients with dementia upon admission to the hospital and the manifestation of behavioral symptoms, and to evaluate the mediating effects of
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Characterization of Balance Control and Postural Stability in Patients With Alzheimer Disease Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-02-20 Raymond J. So, Kevin Biju, Esther Oh, Paul Rosenberg, Qian-Li Xue, Paul Dash, Muhammad H. Burhanullah, Yuri Agrawal
Balance in Alzheimer disease (AD) patients is not rigorously understood. In this study, we characterize balance using qualitative [Berg Balance Scale (BBS)] and quantitative measures (posturography) and assess relationships between qualitative and quantitative balance measures in AD. Patients with mild-moderate AD (n=48) were recruited. BBS scores and posturography metrics, including medial-lateral
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Nasu-Hakola Disease With Stroke-like Attack: A Case Report Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-02-20 Azra Rashid Nezhad, Nahid Olfati, Ali Shoeibi, Fariborz Rezaei Talab, Mohsen Soltani Sabi
Homozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are known to cause Nasu-Hakola disease, which is a rare cause of progressive presenile dementia. A 36-year-old woman presented with repetitive seizures, a 5-year history of progressive behavioral and cognitive changes, and an affected sibling. Magnetic resonance imaging of the brain revealed an ischemic lesion
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Nasu-Hakola Disease With Stroke-like Attack: A Case Report. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-02-20 Azra Rashid Nezhad,Nahid Olfati,Ali Shoeibi,Fariborz Rezaei Talab,Mohsen Soltani Sabi
Homozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are known to cause Nasu-Hakola disease, which is a rare cause of progressive presenile dementia. A 36-year-old woman presented with repetitive seizures, a 5-year history of progressive behavioral and cognitive changes, and an affected sibling. Magnetic resonance imaging of the brain revealed an ischemic lesion
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Characterization of Balance Control and Postural Stability in Patients With Alzheimer Disease. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-02-20 Raymond J So,Kevin Biju,Esther Oh,Paul Rosenberg,Qian-Li Xue,Paul Dash,Muhammad H Burhanullah,Yuri Agrawal
Balance in Alzheimer disease (AD) patients is not rigorously understood. In this study, we characterize balance using qualitative [Berg Balance Scale (BBS)] and quantitative measures (posturography) and assess relationships between qualitative and quantitative balance measures in AD. Patients with mild-moderate AD (n=48) were recruited. BBS scores and posturography metrics, including medial-lateral
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Development and Validation of a Multidimensional Short Version Zarit Burden Interview (ZBI-9) for Caregivers of Persons With Cognitive Impairment. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-18 Lim Zhi-Xiang,Wee Shiong Lim,Ee-Yuee Chan
BACKGROUND There is a lack of appreciation of the full dimensionality of the original 22-item Zarit Burden Interview (ZBI) in the development of short versions. Existing short versions are premised upon a 1-factor or 2-factor structure or statistical techniques for item selection. Thus, there is a need for ZBI short versions that considers the multidimensional constructs of role strain, personal strain
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Predictors of Driving Cessation in Older Adults: A 12-year Population-based Study. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-18 Isabella Wood,Tejal Bhojak,Yichen Jia,Erin Jacobsen,Beth E Snitz,Chung-Chou H Chang,Mary Ganguli
BACKGROUND Changes in physical health and cognition during aging can result in some older adults to stop driving. In this population-based longitudinal study, we describe potential predictors of driving cessation in older adults. METHODS Age-stratified random population cohort of 1982 adults aged 65 years and older drawn from voter registration lists. Participant characteristics were measured using
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Hypothesis: Dementia Diminishes Interdependence in Health and Quality of Life Among Spousal Partners. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-18 Samuel R Nyman,Chloe Casey,Nan Greenwood
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Anticholinergic Drug Burden and Risk of Incident MCI and Dementia: A Population-based Study. Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-18 Ariel Gildengers,Gary P Stoehr,Xinhui Ran,Erin Jacobsen,Esther Teverovsky,Chung-Chou H Chang,Mary Ganguli
OBJECTIVE We investigated whether anticholinergic drug use was related to developing mild cognitive impairment (MCI) or dementia in older adults at the population level. METHODS We used an Anticholinergic Rating (ACR) scale, Clinical Dementia Rating, APOE genotype, and number of prescription medications. We examined time to incident MCI and incident dementia in a population-based cohort (n=1959). We
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Alzheimer’s Disease Neuropathologic Change and Vitamin Supplement Use Decades Earlier: The 90+ Study Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Annlia Paganini-Hill, Syed Bukhari, Thomas J. Montine, Maria M. Corrada, Claudia H. Kawas
Background: Alzheimer’s disease (AD) is the most common cause of dementia. AD neuropathologic change (ADNC) likely begins decades before clinical manifestations. One mechanism implicated in AD is oxidative stress. We explored the potential association of ADNC with antioxidant vitamin supplements taken about 30 years before death. Methods: The 264 brain-autopsied participants were part of The 90+
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Gray Matter Volume as Evidence for Cognitive Reserve in Bilinguals With Mild Cognitive Impairment Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Noelia Calvo, John A.E. Anderson, Matthias Berkes, Morris Freedman, Fergus I.M. Craik, Ellen Bialystok
Background: Compared with monolinguals, bilinguals have a later onset of mild cognitive impairment (MCI) and Alzheimer disease symptoms and greater neuropathology at similar cognitive and clinical levels. The present study follows a previous report showing the faster conversion from MCI to Alzheimer disease for bilingual patients than comparable monolinguals, as predicted by a cognitive reserve (CR)
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Carotid Intima-Media Thickness (cIMT) and Cognitive Performance: A Population-Based Cross-Sectional Study From North India Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Deepti Vibha, Kameshwar Prasad, Sada Nand Dwivedi, Shashi Kant, Awadh Kishor Pandit, Henning Tiemeier, Achal Kumar Srivastava, Ganesan Karthikeyan, Ajay Garg, Vivek Verma, Amit Kumar, Ashima Nehra, Arfan Ikram
Introduction: Atherosclerosis has been shown to impact cognitive impairment, with most of the evidence originating from European, African, or East Asian populations that have employed carotid intima-media thickness (cIMT) as a biomarker for atherosclerosis. Vascular disease is related to dementia/cognitive decline. There is no community-based study from India that has looked at the association of
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Research Priorities of Individuals and Caregivers With Lewy Body Dementia: A Web-based Survey Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Samantha K. Holden, Noheli Bedenfield, Angela S. Taylor, Ece Bayram, Chris Schwilk, Jori Fleisher, John Duda, Holly Shill, Henry L. Paulson, Kelly Stacy, Julia Wood, Pamela Corsentino, Sharon J. Sha, Irene Litvan, David J. Irwin, Joseph F. Quinn, Jennifer G. Goldman, Katherine Amodeo, John-Paul Taylor, Bradley F. Boeve, Melissa J. Armstrong
Introduction: Lewy body dementia (LBD) is common, yet under-recognized and under-researched. To plan studies with the highest impact, engagement of the community personally affected by these conditions is essential. Methods: A web-based survey of people living with LBD and current and former caregivers of people with LBD queried research priorities through forced ranking and exploration of burden
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Physical Exercise as a Nonpharmacological Intervention for the Treatment of Neuropsychiatric Symptoms in Persons With Dementia: A Meta-analysis of Randomized Controlled Trials Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Komanthi Kouloutbani, Fotini Venetsanou, Konstantinos E. Karteroliotis, Antonios Politis
Background: Neuropsychiatric symptoms (NPS) are prevalent in dementia and affect both patients and caregivers in multiple ways. Because of the complications of drug treatments, nonpharmacological interventions, such as exercise, are of particular value. This study aimed to investigate the effect of exercise on the NPS of dementia and draw recommendations for the disease management. Methods: Meta-analyses
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Anticholinergic Drug Burden and Risk of Incident MCI and Dementia: A Population-based Study Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Ariel Gildengers, Gary P. Stoehr, Xinhui Ran, Erin Jacobsen, Esther Teverovsky, Chung-Chou H. Chang, Mary Ganguli
Objective: We investigated whether anticholinergic drug use was related to developing mild cognitive impairment (MCI) or dementia in older adults at the population level. Methods: We used an Anticholinergic Rating (ACR) scale, Clinical Dementia Rating, APOE genotype, and number of prescription medications. We examined time to incident MCI and incident dementia in a population-based cohort (n=1959)
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Predictors of Driving Cessation in Older Adults: A 12-year Population-based Study Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Isabella Wood, Tejal Bhojak, Yichen Jia, Erin Jacobsen, Beth E. Snitz, Chung-Chou H. Chang, Mary Ganguli
Background: Changes in physical health and cognition during aging can result in some older adults to stop driving. In this population-based longitudinal study, we describe potential predictors of driving cessation in older adults. Methods: Age-stratified random population cohort of 1982 adults aged 65 years and older drawn from voter registration lists. Participant characteristics were measured using
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Development and Validation of a Multidimensional Short Version Zarit Burden Interview (ZBI-9) for Caregivers of Persons With Cognitive Impairment Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Lim Zhi-Xiang, Wee Shiong Lim, Ee-Yuee Chan
Background: There is a lack of appreciation of the full dimensionality of the original 22-item Zarit Burden Interview (ZBI) in the development of short versions. Existing short versions are premised upon a 1-factor or 2-factor structure or statistical techniques for item selection. Thus, there is a need for ZBI short versions that considers the multidimensional constructs of role strain, personal
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One Minute of EEG Data Provides Sufficient and Reliable Data for Identifying Lewy Body Dementia Alzheimer Dis. Assoc. Disord. (IF 2.1) Pub Date : 2023-01-01 Lucy Jin, Huma Nawaz, Kenichiro Ono, Justin Nowell, Erik Haley, Brian D. Berman, Nitai D. Mukhopadhyay, Matthew J. Barrett
Objective: To determine the minimum duration of electroencephalography (EEG) data necessary to differentiate EEG features of Lewy body dementia (LBD), that is, dementia with Lewy bodies and Parkinson disease dementia, from non-LBD patients, that is, Alzheimer disease and Parkinson disease. Methods: We performed quantitative EEG analysis for 16 LBD and 14 non-LBD patients. After artifact removal,