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Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-13 Mona Fariborzi; Soo Bin Park; Ali Ozgur; Gyorgy Lur
Adolescence is a time of intense cortical development and a period of heightened sensitivity to insult. To determine how sex affects the short- and long-term outcomes of early-adolescent stress exposure, we subjected prepubescent (postnatal day 30) male and female mice to repeated multiple concurrent stressors (RMS). In the posterior parietal cortex (PPC), RMS caused the elimination of excitatory synapses
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Forecasting individual risk for long-term Posttraumatic Stress Disorder in emergency medical settings using biomedical data: A machine learning multicenter cohort study Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-18 Katharina Schultebraucks; Marit Sijbrandij; Isaac Galatzer-Levy; Joanne Mouthaan; Miranda Olff; Mirjam van Zuiden
The necessary requirement of a traumatic event preceding the development of Posttraumatic Stress Disorder, theoretically allows for administering preventive and early interventions in the early aftermath of such events. Machine learning models including biomedical data to forecast PTSD outcome after trauma are highly promising for detection of individuals most in need of such interventions. In the
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Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-12 Teng Ma; Hao Jin; Lai-Yu Kwok; Zhihong Sun; Min-Tze Liong; Heping Zhang
Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety and depression. Our previous study showed that ingesting the probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress and anxiety of stressed adults. The current study was a follow-up work aiming to investigate the functional role of
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Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-09 Francisco Javier Pavón; Ilham Y. Polis; David G. Stouffer; Benjamin F. Cravatt; Marisa Roberto; Rémi Martin-Fardon; Fernando Rodríguez de Fonseca; Loren H. Parsons; Antonia Serrano
The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated. In this study, we compared the effects of the pharmacological inhibition of the two major endocannabinoid-degrading enzymes [fatty acid amide hydrolase (FAAH) and monoacylglycerol
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Sex differences in the delayed impact of acute stress on the amygdala Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-07 Kanika Gupta; Sumantra Chattarji
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A predictable home environment May protect child mental health during the COVID-19 pandemic Neurobiol. Stress (IF 7.197) Pub Date : 2021-01-06 Laura M. Glynn; Elysia Poggi Davis; Joan L. Luby; Tallie Z. Baram; Curt A. Sandman
Objective Information about the adverse effects of the COVID-19 pandemic on adolescent and adult mental health is growing, yet the impacts on preschool children are only emerging. Importantly, environmental factors that augment or protect from the multidimensional and stressful influences of the pandemic on emotional development of young children are poorly understood. Methods Depressive symptoms in
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“Live together, die alone”: The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-29 Daniela S. Rivera; Carolina B. Lindsay; Carolina A. Oliva; Francisco Bozinovic; Nibaldo C. Inestrosa
Loneliness affects group-living mammals triggering a cascade of stress-dependent physiological disorders. Indeed, social isolation stress is a major risk factor for several neuropsychiatric disorders including anxiety and depression. Furthermore, social isolation has a negative impact on health and fitness. However, the neurobiological consequences of long-term chronic social isolation stress (LTCSIS)
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Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-29 Marija Milic; Ulrich Schmitt; Beat Lutz; Marianne B. Müller
Chronic social defeat (CSD) has been widely used as a psychosocial stress model in mice, with the magnitude of CSD-induced social avoidance as the major behavioral hallmark of the resilient and susceptible groups. Despite significant progress in the study of the neurobiology of resilient and susceptible mice, the nature and ethological relevance of CSD-induced social avoidance and social approach,
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A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-24 Sebastiano A. Torrisi; Gianluca Lavanco; Oriana M. Maurel; Walter Gulisano; Samuele Laudani; Federica Geraci; Margherita Grasso; Cristina Barbagallo; Filippo Caraci; Claudio Bucolo; Marco Ragusa; Francesco Papaleo; Patrizia Campolongo; Daniela Puzzo; Filippo Drago; Salvatore Salomone; Gian Marco Leggio
Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These models should encompass crucial features, including persistence of PTSD-like phenotypes triggered after exposure to a single traumatic event, trauma susceptibility/resilience and predictive validity. Here we propose a
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The functional connectome predicts feeling of stress on regular days and during the COVID-19 pandemic Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-17 Peiduo Liu; Wenjing Yang; Kaixiang Zhuang; Dongtao Wei; Rongjun Yu; Xiting Huang; Jiang Qiu
Although many studies have explored the neural mechanism of the feeling of stress, to date, no effort has been made to establish a model capable of predicting the feeling of stress at the individual level using the resting-state functional connectome. Although individuals may be confronted with multidimensional stressors during the coronavirus disease 2019 (COVID-19) pandemic, their appraisal of the
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Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study) Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-24 Elaine Patterson; Síle M. Griffin; Alvin Ibarra; Emilia Ellsiepen; Juliane Hellhammer
Chronic stress is a risk-factor for the development of mood and stress-related disorders. Clinical evidence indicates that probiotics can influence the stress response and mood. The Sisu study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could modulate stress, mood and well-being. Prior to a two-week run-in period, 120 healthy adults (18-45 y) were stratified for sex and chronic
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LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-27 A. Longaretti; C. Forastieri; E. Toffolo; L. Caffino; A. Locarno; I. Misevičiūtė; E. Marchesi; M. Battistin; L. Ponzoni; L. Madaschi; C. Cambria; M.P. Bonasoni; M. Sala; D. Perrone; F. Fumagalli; S. Bassani; F. Antonucci; R. Tonini; F. Rusconi
Along with neuronal mechanisms devoted to memory consolidation –including long term potentiation of synaptic strength as prominent electrophysiological correlate, and inherent dendritic spines stabilization as structural counterpart– negative control of memory formation and synaptic plasticity has been described at the molecular and behavioral level. Within this work, we report a role for the epigenetic
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Pregnancy associated epigenetic markers of inflammation predict depression and anxiety symptoms in response to discrimination Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-21 Femke Sluiter; Angela C. Incollingo Rodriguez; Benjamin C. Nephew; Ryan Cali; Chris Murgatroyd; Hudson P. Santos
Latina mothers, who have one of the highest fertility rates among ethnic groups in the United States (US), often experience discrimination. Psychosocial influences during pregnancy, such as discrimination stress, promotes inflammation. However, the role of epigenetic markers of inflammation as a mediator between, and predictor of, maternal discrimination stress and neuropsychiatric outcomes has not
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Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-24 Meghan Donovan; Calvin S. Mackey; Grayson N. Platt; Jacob Rounds; Amber N. Brown; Darryl J. Trickey; Yan Liu; Kathryn M. Jones; Zuoxin Wang
The absence of social support, or social isolation, can be stressful, leading to a suite of physical and psychological health issues. Growing evidence suggests that disruption of the gut-immune-brain axis plays a crucial role in the negative outcomes seen from social isolation stress. However, the mechanisms remain largely unknown. The socially monogamous prairie vole (Microtus ochrogaster) has been
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Stress induces divergent gene expression among lateral habenula efferent pathways Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-16 Marjorie R. Levinstein; Kevin R. Coffey; Russell G. Marx; Atom J. Lesiak; John F. Neumaier
The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. The three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and the rostromedial tegmental nucleus (RMTg). LHb neurons that project to these targets are segregated and nonoverlapping, and this led us to consider whether they
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A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-30 Agbonlahor Okhuarobo; Jessica L. Bolton; Ighodaro Igbe; Eric P. Zorrilla; Tallie Z. Baram; Candice Contet
Childhood adversity increases vulnerability to alcohol use disorders and preclinical models are needed to investigate the underlying neurobiological mechanisms. The present study modeled early-life adversity by rearing male and female C57BL/6J mouse pups in a limited bedding and nesting (LBN) environment, which induces erratic maternal care. As adults, mice were given limited access to two-bottle choice
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Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-23 Annamaria Cattaneo; Matthew Suderman; Nadia Cattane; Monica Mazzelli; Veronica Begni; Carlo Maj; Ilari D'Aprile; Carmine M. Pariante; Alessia Luoni; Alessandra Berry; Katharina Wurst; Leif Hommers; Katharina Domschke; Francesca Cirulli; Moshe Szyf; Andreas Menke; Marco A. Riva
Exposure to early life stress can interfere with neurodevelopmental trajectories to increase the vulnerability for psychiatric disorders later in life. With this respect, epigenetic mechanisms play a key role for the long-lasting changes in brain functions that may elicit and sustain psychopathologic outcomes. Here, we investigated DNA methylation changes as possible epigenetic mechanism mediating
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Programming effects of peripubertal stress on spatial learning Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-01 S. Tzanoulinou; E. Gantelet; C. Sandi; C. Márquez
Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term consequences in the emotional and social domains. However, little is known about how stress during this period impacts subsequent cognitive functioning
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Sex differences in endocannabinoid modulation of rat CA1 dendritic neurotransmission Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-30 Angelica Ferraro; Philip Wig; Joseph Boscarino; Christian G. Reich
Endocannabinoid sex differences are present in the rat hippocampus. Specifically, at perisomatic GABAergic synapses, tonic anandamide (AEA) and estrogenic-AEA signaling are active in females but not males. Furthermore, in males, hippocampal eCB function varies along the CA1 pyramidal somatodendritic axis. Constitutive CB1 and tonic 2-AG activity are present at perisomatic GABAergic synapses and lacking
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Hormonal contraceptive phases matter: Resting-state functional connectivity of emotion-processing regions under stress Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-21 Padideh Nasseri; Alexandra Ycaza Herrera; Katherine Gillette; Sophia Faude; Jessica D. White; Ricardo Velasco; Mara Mather
Hormonal contraceptives (HCs) affect various processes related to emotion processing, including emotional memory, fear extinction, and the cortisol response to stress. Despite the modulating role of HCs on the stress response in women and variance in synthetic hormone levels across the HC cycle, little is known about the phase-related effects of HCs on the brain's response to stress. We investigated
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Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior Neurobiol. Stress (IF 7.197) Pub Date : 2020-12-05 Olga Borodovitsyna; Brenna C. Duffy; Anthony E. Pickering; Daniel J. Chandler
The locus coeruleus (LC) is a critical node in the stress response, and its activation has been shown to promote hypervigilance and anxiety-like behavior. This noradrenergic nucleus has historically been considered homogeneous with highly divergent neurons that operate en masse to collectively affect central nervous system function and behavioral state. However, in recent years, LC has been identified
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Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-30 Devin M. Kellis; Kris Ford Kaigler; Eric Witherspoon; Jim R. Fadel; Marlene A. Wilson
Cholinergic neuromodulation plays an important role in numerous cognitive functions including regulating arousal and attention, as well as associative learning and extinction processes. Further, studies demonstrate that cholinergic inputs from the basal forebrain cholinergic system influence physiological responses in the basolateral amygdala (BLA) as well as fear extinction processes. Since rodent
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Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-29 H. Scott; T.J. Phillips; Y. Sze; A. Alfieri; M.F. Rogers; V. Volpato; C.P. Case; P.J. Brunton
Maternal exposure to stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. The mechanisms through which the effects of maternal stress are transmitted to the fetus are unclear, however the placenta, as the interface between mother and fetus, is likely to play a key role. Using a rat model, we investigated a role for placental oxidative
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A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-21 Anna Suarez; Jari Lahti; Marius Lahti-Pulkkinen; Polina Girchenko; Darina Czamara; Janine Arloth; Anni LK. Malmberg; Esa Hämäläinen; Eero Kajantie; Hannele Laivuori; Pia M. Villa; Rebecca M. Reynolds; Nadine Provençal; Elisabeth B. Binder; Katri Räikkönen
Background Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) and harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in utero exposure to GC is associated with mental and behavioral disorders and their severity in children, possibly mediating the associations between maternal prenatal depressive and
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Increased methylation of NR3C1 and SLC6A4 is associated with blunted cortisol reactivity to stress in major depression Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-21 Jelena Bakusic; Elske Vrieze; Manosij Ghosh; Bram Bekaert; Stephan Claes; Lode Godderis
Background Epigenetic changes are considered the main mechanisms behind the interplay of environment and genetic susceptibility in major depressive disorder (MDD). However, studies focusing on epigenetic dysregulation of the HPA axis stress response in MDD are lacking. Our objective was to simultaneously asses DNA methylation of the glucocorticoid receptor gene (NR3C1) and serotonin transporter gene
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Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-23 Sebastian A. Pace; Connor Christensen; Morgan K. Schackmuth; Tyler Wallace; Jessica M. McKlveen; Will Beischel; Rachel Morano; Jessie R. Scheimann; Steven P. Wilson; James P. Herman; Brent Myers
Exposure to prolonged stress is a major risk-factor for psychiatric disorders such as generalized anxiety and major depressive disorder. Human imaging studies have identified structural and functional abnormalities in the prefrontal cortex of subjects with depression and anxiety disorders, particularly Brodmann's area 25 (BA25). Further, deep brain stimulation of BA25 reduces symptoms of treatment-resistant
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Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-21 Dominic Kaul; Caine C. Smith; Julia Stevens; Anna S. Fröhlich; Elisabeth B. Binder; Naguib Mechawar; Sibylle G. Schwab; Natalie Matosin
Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of stress exposure on the human brain remain poorly understood. Using a novel postmortem cohort of psychiatric
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Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-17 Sarah C. Simmons; Ryan D. Shepard; Shawn Gouty; Ludovic D. Langlois; William J. Flerlage; Brian M. Cox; Fereshteh S. Nugent
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Maternal stress programs accelerated aging of the basal ganglia motor system in offspring Neurobiol. Stress (IF 7.197) Pub Date : 2020-11-02 Jordan Marrocco; Remy Verhaeghe; Domenico Bucci; Luisa Di Menna; Anna Traficante; Hammou Bouwalerh; Gilles Van Camp; Veronica Ghiglieri; Barbara Picconi; Paolo Calabresi; Laura Ravasi; Francesca Cisani; Farzaneh Bagheri; Anna Pittaluga; Valeria Bruno; Giuseppe Battaglia; Sara Morley-Fletcher; Ferdinando Nicoletti; Stefania Maccari
Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male
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Gender-related time course of sleep disturbances and psychological symptoms during the COVID-19 lockdown: A longitudinal study on the Italian population Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-20 Federico Salfi; Marco Lauriola; Giulia Amicucci; Domenico Corigliano; Lorenzo Viselli; Daniela Tempesta; Michele Ferrara
Italy was the first western hotspot of the COVID-19 pandemic. In order to contain the spread of the virus, the Italian Government imposed home confinement to the entire population for almost two months. The present study is the first large-scale longitudinal report of the sleep and mental health changes during the prolonged lockdown due to the COVID-19 outbreak. We focused on the gendered vulnerability
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A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-31 Xinwen Dong; Sa Li; Gilbert J. Kirouac
The paraventricular nucleus of the thalamus (PVT) is an area of the dorsal midline thalamus that contributes to footshock induced anxiety. The PVT sends a dense projection to the shell of the nucleus accumbens (NAcSh) and the present study explored if this projection is involved in the behavioral changes produced by a single exposure of rats to inescapable footshocks. The inhibitory Designer Receptors
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Optogenetically-induced long term depression in the rat orbitofrontal cortex ameliorates stress-induced reversal learning impairment Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-24 Samantha M. Adler; Milena Girotti; David A. Morilak
Cognitive flexibility is a higher-order executive function that requires plasticity in neuronal circuits of the prefrontal cortex. Deficits in cognitive flexibility are prominent in a variety of psychiatric disorders, such as major depression, obsessive-compulsive disorder, and posttraumatic stress disorder. Chronic stress induces deficits in cognitive flexibility, perhaps through effects on plasticity
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Prevalence of posttraumatic stress symptoms in health care workers after exposure to patients with COVID-19 Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-17 Hao Chen; Bin Wang; Yanbo Cheng; Bilal Muhammad; Shengli Li; Zhigang Miao; Bo Wan; Mannan Abdul; Zhong Zhao; Deqin Geng; Xingshun Xu
Objective To investigate the prevalence of posttraumatic stress symptoms (PTSS) of health care workers (HCWs) who were potentially or directly exposed to patients with coronavirus disease 2019 (COVID-19) in a non-core epidemic area of China. Methods Psychological conditions were evaluated by the multiple psychological evaluation scales in HCWs at the Affiliated Hospital of Xuzhou Medical University
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Transcutaneous cervical vagal nerve stimulation reduces sympathetic responses to stress in posttraumatic stress disorder: A double-blind, randomized, sham controlled trial Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-20 Nil Z. Gurel; Matthew T. Wittbrodt; Hewon Jung; Md. Mobashir H. Shandhi; Emily G. Driggers; Stacy L. Ladd; Minxuan Huang; Yi-An Ko; Lucy Shallenberger; Joy Beckwith; Jonathon A. Nye; Bradley D. Pearce; Viola Vaccarino; Amit J. Shah; Omer T. Inan; J. Douglas Bremner
Objective Exacerbated autonomic responses to acute stress are prevalent in posttraumatic stress disorder (PTSD). The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to acute stress in patients with PTSD. The authors hypothesized tcVNS would reduce the sympathetic response to stress compared to a sham device. Methods Using a randomized double-blind
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Mediterranean diet, stress resilience, and aging in nonhuman primates Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-19 Carol A. Shively; Susan E. Appt; Haiying Chen; Stephen M. Day; Brett M. Frye; Hossam A. Shaltout; Marnie G. Silverstein-Metzler; Noah Snyder-Mackler; Beth Uberseder; Mara Z. Vitolins; Thomas C. Register
Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on
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Behavioral response to fluoxetine in both female and male mice is modulated by dentate gyrus granule cell activity Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-17 Christine N. Yohn; Andrew Dieterich; Isabella Maita; Allyson S. Bazer; Emma Diethorn; Debbie Ma; Mark M. Gergues; Pu Hu; Benjamin A. Samuels
Depression is a complex psychiatric disorder that is a major burden on society, with only ~33% of depressed patients attaining remission upon initial monotherapy with a selective serotonin reuptake inhibitor (SSRI). In preclinical studies using rodents, chronic stress paradigms, such as chronic corticosterone and social instability stress, are used to induce avoidance behaviors associated with negative
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Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-17 G. Rodriguez; S.J. Moore; R.C. Neff; E.D. Glass; T.K. Stevenson; G.S. Stinnett; A.F. Seasholtz; G.G. Murphy; V.A. Cazares
Acute physical or psychological stress can elicit adaptive behaviors that allow an organism maintain homeostasis. However, intense and/or prolonged stressors often have the opposite effect, resulting in maladaptive behaviors and curbing goal-directed action; in the extreme, this may contribute to the development of psychiatric conditions like generalized anxiety disorder, major depressive disorder
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Cannabis vapor self-administration elicits sex- and dose-specific alterations in stress reactivity in rats Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-18 Nicholas C. Glodosky; Carrie Cuttler; Timothy G. Freels; Hayden R. Wright; Manuel J. Rojas; Samantha L. Baglot; Matthew N. Hill; Ryan J. McLaughlin
Rationale Cannabis users frequently report stress relief as their primary reason for use. Recent studies indicate that human cannabis users exhibit blunted stress reactivity; however, it is unknown whether this is a cause or a consequence of chronic cannabis use. Objectives To determine whether chronic cannabis vapor self-administration elicits sex- and/or dose-dependent alterations in stress reactivity
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A sex-dependent delayed maturation of visual plasticity induced by adverse experiences in early childhood Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-14 Yueqin Liu; Zhenni Wang; Xinxin Zhang; Sitong Li; Wei Wu; Xin Li; Yupeng Yang
Adverse experiences in early life have a long-term impact on the development of brain, which in turn increases the susceptibility to mental illness during adulthood, especially in female subjects. However, whether and how the visual cortex is affected by these adverse experiences as well as the mechanisms underlying the sex difference are largely unknown. Here, we established a new mouse model of early-life
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Validation of an Electrochemical Sensor to Detect Cortisol Responses to the Trier Social Stress Test Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-20 Guido G. Urizar; Hugo Sanchez Hernandez; Jessica Rayo; Shekhar Bhansali
Recent advances in sensor technology allow for the detection of salivary cortisol levels in real-time, yet studies are needed to test their reliability in clinically at-risk populations. This study examined whether a new electrochemical sensor reliably detected cortisol patterns, compared to a conventional immunoassay test (i.e., ELISA), among women and men with low and high depressive symptoms who
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Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-10-05 Victor A.D. Holanda; Matheus C. Oliveira; Edilson D. Da Silva Junior; Girolamo Calo'; Chiara Ruzza; Elaine C. Gavioli
The role of stress in the etiology of depression has been largely reported. In this line, exogenous glucocorticoids are employed to mimic the influence of stress on the development of depression. The N/OFQ-NOP receptor system has been implicated in the modulation of stress and emotional behaviors. In fact, the blockade of NOP receptors induces antidepressant effects and increases resilience to acute
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Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-09-28 Rachel Anne Hill; Adrienne Mary Grech; Michael J. Notaras; Mauricio Sepulveda; Maarten van den Buuse
Brain-derived neurotrophic factor (BDNF) plays essential roles in GABAergic interneuron development. The common BDNF val66met polymorphism, leads to decreased activity-dependent release of BDNF. The current study used a humanized mouse model of the BDNF val66met polymorphism to determine how reduced activity-dependent release of BDNF, both on its own, and in combination with chronic adolescent stress
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Neurobiological effects of phospholipids in vitro: Relevance to stress-related disorders Neurobiol. Stress (IF 7.197) Pub Date : 2020-09-15 Francisco Donoso; Marina Schverer; Kieran Rea; Matteo M. Pusceddu; Bernard L. Roy; Timothy G. Dinan; John F. Cryan; Harriët Schellekens
Nutrition is a crucial component for maintenance of brain function and mental health. Accumulating evidence suggests that certain molecular compounds derived from diet can exert neuroprotective effects against chronic stress, and moreover improve important neuronal processes vulnerable to the stress response, such as plasticity and neurogenesis. Phospholipids are naturally occurring amphipathic molecules
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Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults Neurobiol. Stress (IF 7.197) Pub Date : 2020-09-13 Kathie L. Eagleson, Miranda Villaneuva, Rebecca M. Southern, Pat Levitt
Exposure to early-life stress (ELS) increases risk for poor mental and physical health outcomes that emerge at different stages across the lifespan. Yet, how age interacts with ELS to impact the expression of specific phenotypes remains largely unknown. An established limited-bedding paradigm was used to induce ELS in mouse pups over the early postnatal period. Initial analyses focused on the hippocampus
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Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats Neurobiol. Stress (IF 7.197) Pub Date : 2020-09-03 Jadwiga Spyrka, Anna Gugula, Agnieszka Rak, Grzegorz Tylko, Grzegorz Hess, Anna Blasiak
Childhood maltreatment, which can take the form of physical or psychological abuse, is experienced by more than a quarter of all children. Early life stress has substantial and long-term consequences, including an increased risk of drug abuse and psychiatric disorders in adolescence and adulthood, and this risk is higher in women than in men. The neuronal mechanisms underlying the influence of early
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Exposure to different early-life stress experiences results in differentially altered DNA methylation in the brain and immune system Neurobiol. Stress (IF 7.197) Pub Date : 2020-09-02 Clarissa Catale, Silvia Bussone, Luisa Lo Iacono, Maria Teresa Viscomi, Daniela Palacios, Alfonso Troisi, Valeria Carola
The existence of a proportional relationship between the number of early-life stress (ELS) events experienced and the impoverishment of child mental health has been hypothesized. However, different types of ELS experiences may be associated with different neuro-psycho-biological impacts, due to differences in the intrinsic nature of the stress. DNA methylation is one of the molecular mechanisms that
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Brain activity during a post-stress working memory task differs between the hormone-present and hormone-absent phase of hormonal contraception Neurobiol. Stress (IF 7.197) Pub Date : 2020-08-21 Alexandra Ycaza Herrera, Ricardo Velasco, Sophia Faude, Jessica D. White, Philipp C. Opitz, Ringo Huang, Kristie Tu, Mara Mather
Taking hormonal contraceptives (HCs) affects the magnitude of the hormonal stress response and cognition. HCs are usually administered in a monthly cycle with both synthetic-hormone-containing and synthetic-hormone-absent phases. The synthetic hormones contained in HCs affect a wide range of neurophysiological systems, suggesting that effects of the medication might only be observed during the syn
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Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements. Neurobiol. Stress (IF 7.197) Pub Date : 2020-08-05 Graziano Pinna
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Social defeat: Vagal reduction and vulnerability to ventricular arrhythmias Neurobiol. Stress (IF 7.197) Pub Date : 2020-08-03 Charly Brouillard, Pascal Carrive, Caroline Sévoz-Couche
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BNST transient activity associates with approach behavior in a stressful environment and is modulated by the parabrachial nucleus Neurobiol. Stress (IF 7.197) Pub Date : 2020-08-01 A.A. Jaramillo, K.M. Williford, C. Marshall, D.G. Winder, S.W. Centanni
Studies demonstrate a role for the bed nucleus of the stria terminalis (BNST) in modulating affective behavior and stress-reward integration. To explore the dynamic nature of in vivo BNST activity associated with anxiety-like behavior in a stress-inducing context, we utilized fiber photometry and detected BNST calcium transients in mice during the novelty-suppressed feeding task (NSFT). Phasic BNST
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Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-27 Lil Meyer-Arndt, Stefan Hetzer, Susanna Asseyer, Judith Bellmann-Strobl, Michael Scheel, Jan-Patrick Stellmann, Christoph Heesen, Andreas K. Engel, Alexander U. Brandt, John-Dylan Haynes, Friedemann Paul, Stefan M. Gold, Martin Weygandt
Background Multiple sclerosis (MS) is characterized by two neuropathological key aspects: inflammation and neurodegeneration. Clinical studies support a prospective link between psychological stress and subsequent inflammatory disease activity. However, it is unknown if a similar link exists for grey matter (GM) degeneration as the key driver of irreversible disability. Methods We tested whether neural
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miR-34a induces spine damages via inhibiting synaptotagmin-1 in depression Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-22 Li-Tao Yi, Ji-Xiao Zhu, Shu-Qi Dong, Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Qing Liu
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Reproductive status impact on tau phosphorylation induced by chronic stress Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-20 Daniel Muñoz-Mayorga, Robert A. Rissman, Teresa Morales
Sex and exposure to chronic stress have been identified as risk factors for developing Alzheimer's disease (AD). Although AD has been demonstrated to be more prevalent in females, sex is often overlooked in research studies, likely due to the complexity of the hormonal status. In female rats, the reproductive status can modulate the well-known increase in tau phosphorylation (pTau) caused by the exposure
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Differential effects of two early life stress paradigms on cerebellar-dependent delay eyeblink conditioning Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-17 Alexandra B. Moussa-Tooks, William P. Hetrick, John T. Green
Early life stress paradigms have become prominent in the animal literature to model atypical development. Currently, two models have prevailed within the literature: (1) limited bedding or nesting and (2) maternal separation or deprivation. Both models have produced aberrations spanning behavior and neural circuitry. Surprisingly, these two models have yet to be directly compared. The current study
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Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-13 Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J. Lin, Joshua B. Foster, Tianqi Xiao, Nydia Kung, Candice C. Askwith, John P. Bruno, Valentina Valentini, Kevin J. Hodgetts, Chien-liang Glenn Lin
Gulf War illness is associated with a combination of exposure to war-related chemical agents and traumatic stress. Currently, there are no effective treatments, and the pathophysiology remains elusive. Neurological problems are among the most commonly reported symptoms. In this study, we investigated the glutamatergic system in the hippocampi of mice exposed to war-related chemical agents and stress
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Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-10 Sarah J. Jefferson, Mengyang Feng, URee Chon, Yao Guo, Yongsoo Kim, Bernhard Luscher
Chronic stress represents a vulnerability factor for anxiety and depressive disorders and has been widely used to model aspects of these disorders in rodents. Disinhibition of somatostatin (SST)-positive GABAergic interneurons in mice by deletion of γ2 GABAA receptors selectively from these cells (SSTCre:γ2f/f mice) has been shown to result in behavioral and biochemical changes that mimic the responses
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The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice Neurobiol. Stress (IF 7.197) Pub Date : 2020-07-04 Elmira Anderzhanova, Kathrin Hafner, Andreas J. Genewsky, Azza Soliman, Max L. Pöhlmann, Mathias V. Schmidt, Robert Blum, Carsten T. Wotjak, Nils C. Gassen
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Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress Neurobiol. Stress (IF 7.197) Pub Date : 2020-06-24 Miyoung Yang, Qi Ding, Ming Zhang, Changjong Moon, Hongbing Wang
The ability to cope with stress is essential for emotional stability and mental health. It is also hypothesized that factors promoting resilience to stress may offer treatment strategies for maladaptive disorders such as anxiety and depression. Here, we find that physical restraint reduces the expression of type 1 adenylyl cyclase (Adcy1), a neurospecific synaptic enzyme that positively regulates the
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Sex and chronic stress alter delta opioid receptor distribution within rat hippocampal CA1 pyramidal cells following behavioral challenges Neurobiol. Stress (IF 7.197) Pub Date : 2020-06-22 Batsheva R. Rubin, Megan A. Johnson, Jared M. Berman, Ellen Goldstein, Vera Pertsovskaya, Yan Zhou, Natalina H. Contoreggi, Andreina G. Dyer, Jason D. Gray, Elizabeth M. Waters, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner