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Invited review-special issue “stress and alcohol” a gut (microbiome) feeling about addiction: Interactions with stress and social systems Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-18 Rubén García-Cabrerizo, John F. Cryan
In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut and their impact on brain health and central nervous system disease. There has been a shift in mindset to understand that drug addiction is not merely a condition that affects the brain, it is now being recognized as a disorder that also involves external factors such as
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β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: Potential role in stress-induced cognitive dysfunction Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-15 M.K.P. Joyce, S. Yang, K. Morin, A. Duque, J. Arellano, D. Datta, M. Wang, A.F.T. Arnsten
Uncontrollable stress exposure impairs working memory and reduces the firing of dorsolateral prefrontal cortex (dlPFC) “Delay cells”, involving high levels of norepinephrine and dopamine release. Previous work has focused on catecholamine actions on dlPFC pyramidal cells, but inhibitory interneurons may contribute as well. The current study combined immunohistochemistry and multi-scale microscopy with
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Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-11 Guopeng Chen, Yuhui Zhang, Ruiling Li, Liuyin Jin, Keke Hao, Jingtong Rong, Hao Duan, Yiwei Du, Lihua Yao, Dan Xiang, Zhongchun Liu
Gestational stress can exacerbate postpartum depression (PPD), for which treatment options remain limited. Environmental enrichment (EE) may be a therapeutic intervention for neuropsychiatric disorders, including depression, but the specific mechanisms by which EE might impact PPD remain unknown. Here we examined the behavioral, molecular, and cellular impact of EE in a stable PPD model in rats developed
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Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-11 Cuihong Jia, W. Drew Gill, Chiharu Lovins, Russell W. Brown, Theo Hagg
Astrocytes have been implicated in stress responses and produce ciliary neurotrophic factor (CNTF), which we have shown in the mouse medial amygdala (MeA) to promote passive stress coping response only in females. Pharmacological inhibition of focal adhesion kinase (FAK) upregulates CNTF expression. Here, we found that inducible knockout of FAK in astrocytes or systemic treatment with an FAK inhibitor
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The neurocomputational signature of decision-making for unfair offers in females under acute psychological stress Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-06 Guangya Wang, Jun Tang, Zhouqian Yin, Siyu Yu, Xindi Shi, Xiurong Hao, Zhudele Zhao, Yafeng Pan, Shijia Li
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SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-05 Gisela Armada, Susana Roque, Cláudia Serre-Miranda, Liliana Ferreira, Ana Vale, Ana João Rodrigues, Wanjin Hong, Margarida Correia-Neves, Neide Vieira
Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor that shapes excitatory control, being relevant for cognitive and reward processing, and for several neurological conditions. Despite this, SNX27's role in the nervous system remains poorly explored. To further understand SNX27 function, we performed an extensive behavioral characterization comprising motor, cognitive and
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Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats Neurobiol. Stress (IF 5.0) Pub Date : 2024-03-02 Valeria Lallai, Cristina Congiu, Giulia Craig, Letizia Manca, Yen-Chu Chen, Angeline J. Dukes, Christie D. Fowler, Laura Dazzi
Early development is characterized by dynamic transitions in brain maturation, which may be impacted by environmental factors. Here, we sought to determine the effects of social isolation from postweaning and during adolescence on reward behavior and dopaminergic signaling in male rats. Subjects were socially isolated or group housed at postnatal day 21. Three weeks later, extracellular dopamine concentrations
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Sex-specific threat responding and neuronal engagement in carbon dioxide associated fear and extinction: Noradrenergic involvement in female mice Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-20 Rebecca Ahlbrand, Allison Wilson, Patrick Woller, Yuv Sachdeva, Jayden Lai, Nikki Davis, James Wiggins, Renu Sah
Difficulty in appropriately responding to threats is a key feature of psychiatric disorders, especially fear-related conditions such as panic disorder (PD) and posttraumatic stress disorder (PTSD). Most prior work on threat and fear regulation involves exposure to external threatful cues. However, fear can also be triggered by aversive, within-the-body, sensations. This interoceptive signaling of fear
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The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-20 Megan E. Castle, Meghan E. Flanigan
Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide, but current treatments are insufficient in fully addressing the symptoms that often lead to relapses in alcohol consumption. The brain's serotonin system has been implicated in AUD for decades and is a major regulator of stress-related behaviors associated with increased alcohol consumption. This review will discuss the
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Isolation of the differential effects of chronic and acute stress in a manner that is not confounded by stress severity Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-10 Michael A. Conoscenti, Daniel B. Weatherill, Yuqing Huang, Raphael Tordjman, Michael S. Fanselow
Firm conclusions regarding the differential effects of the maladaptive consequences of acute versus chronic stress on the etiology and symptomatology of stress disorders await a model that isolates chronicity as a variable for studying the differential effects of acute versus chronic stress. This is because most previous studies have confounded chronicity with the total amount of stress. Here, we have
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Integrating and fragmenting memories under stress and alcohol Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-08 Krystian B. Loetscher, Elizabeth V. Goldfarb
Stress can powerfully influence the way we form memories, particularly the extent to which they are integrated or situated within an underlying spatiotemporal and broader knowledge architecture. These different representations in turn have significant consequences for the way we use these memories to guide later behavior. Puzzlingly, although stress has historically been argued to promote fragmentation
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Does sleep promote adaptation to acute stress: An experimental study Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-04 Emil Hein, Risto Halonen, Thomas Wolbers, Tommi Makkonen, Markus Kyllönen, Liisa Kuula, Ilmari Kurki, Philipp Stepnicka, Anu-Katriina Pesonen
Evidence of the impact of chronic stress on sleep is abundant, yet experimental sleep studies with a focus on acute stress are scarce and the results are mixed. Our study aimed to fill this gap by experimentally investigating the effects of pre-sleep social stress on sleep dynamics during the subsequent night, as measured with polysomnography (PSG). Thirty-four healthy individuals (65% females, M = 25
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Prenatal and postnatal influences on behavioral development in a mouse model of preconceptional stress Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-03 Joseph Scarborough, Monica Iachizzi, Sina M. Schalbetter, Flavia S. Müller, Ulrike Weber-Stadlbauer, Juliet Richetto
Depression during pregnancy is detrimental for the wellbeing of the expectant mother and can exert long-term consequences on the offspring's development and mental health. In this context, both the gestational environment and the postpartum milieu may be negatively affected by the depressive pathology. It is, however, challenging to assess whether the contributions of prenatal and postnatal depression
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Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice Neurobiol. Stress (IF 5.0) Pub Date : 2024-02-02 Joyce Liu, Daniel J. Lustberg, Abigail Galvez, L. Cameron Liles, Katharine E. McCann, David Weinshenker
In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE) and dopamine (DA) modulate anxiety and predator odor responses, and we have shown previously that dopamine β-hydroxylase knockout (, which reduces NE and increases DA in mouse noradrenergic neurons, disrupts
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Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-22 Stephanie A. Sassoon, Rosemary Fama, Kilian M. Pohl, Adolf Pfefferbaum, Edith V. Sullivan
Childhood abuse is an underappreciated source of stress, associated with adverse mental and physical health consequences. Childhood abuse has been directly associated with risky behavior thereby increasing the likelihood of alcohol misuse and risk of HIV infection, conditions associated with brain structural and functional deficits. Here, we examined the neural and behavioral correlates of childhood
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Imaging a putative marker of brain cortisol regulation in alcohol use disorder Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-21 Terril L. Verplaetse, Ansel T. Hillmer, Shivani Bhatt, Aleksandra Rusowicz, Songye Li, Nabeel Nabulsi, David Matuskey, Yiyun Huang, Sherry A. McKee, Kelly P. Cosgrove
Stress is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis, initiating the release of glucocorticoid hormones, such as cortisol. Alcohol consumption can lead to HPA axis dysfunction, including altered cortisol levels. Until recently, research has only been able to examine peripheral cortisol associated with alcohol use disorder (AUD) in humans. We used positron emission tomography
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Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-15 Claire Deckers, Reza Karbalaei, Nylah A. Miles, Eden V. Harder, Emily Witt, Erin P. Harris, Kathryn Reissner, Mathieu E. Wimmer, Debra A. Bangasser
Astrocyte morphology affects function, including the regulation of glutamatergic signaling. This morphology changes dynamically in response to the environment. However, how early life manipulations alter adult cortical astrocyte morphology is underexplored. Our lab uses brief postnatal resource scarcity, the limited bedding and nesting (LBN) manipulation, in rats. We previously found that LBN augments
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Fear conditioning and extinction distinctively alter bidirectional synaptic plasticity within the amygdala of an animal model of post-traumatic stress disorder Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-12 Kwanghoon Park, Hoyong Park, ChiHye Chung
Synaptic plasticity in the amygdala plays an essential role in the formation and inhibition of fear memory; however, this plasticity has mainly been studied in the lateral amygdala, making it largely uninvestigated in other subnuclei. Here, we investigated long-term potentiation (LTP) and long-term depression (LTD) in the basolateral amygdala (BLA) to the medial division of the central amygdala (CEm)
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A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-05 Barbara J. Mason, David Estey, Amanda Roberts, Giordano de Guglielmo, Olivier George, John Light, Mike Stoolmiller, Susan Quello, Michael Skinner, Farhad Shadan, Adnan Begovic, Mark C. Kyle, R. Adron Harris
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Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline Neurobiol. Stress (IF 5.0) Pub Date : 2024-01-04 Laurel R. Seemiller, Julio Flores-Cuadra, Keith R. Griffith, Grace C. Smith, Nicole A. Crowley
Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated
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Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-25 Rachel C. Rice, Daniela V. Gil, Annalisa M. Baratta, Remy R. Frawley, Shirley Y. Hill, Sean P. Farris, Gregg E. Homanics
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an individual’s behavior through molecular adaptations that do not change the DNA sequence, but instead change gene expression. A recent wealth of research has found that these nongenomic changes can be transmitted across generations, which could partially account for the “missing heritability” observed in genome-wide association
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Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-15 Zhenlong Li, Chau-Shoun Lee, Si Chen, Benyu He, Xinya Chen, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Dylan Chou
Light is an underappreciated mood manipulator. People are often exposed to electronic equipment, which results in nocturnal blue light exposure in modern society. Light pollution drastically shortens the night phase of the circadian rhythm. Preclinical and clinical studies have reported that nocturnal light exposure can influence mood, such as depressive-like phenotypes. However, the effects of blue
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An epigenetic mechanism of social isolation stress in adolescent female mice Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-18 Pei Li, Zhen Yan
Social isolation during adolescence can increase the risk of mental disorders. Epigenetic changes induced by chronic social isolation may serve as a mechanism underlying emotional disturbances. To test this, we exposed female mice to a post-weaning 6-week social isolation (SI) stress. We found the significantly increased methylation of histone H3 at lysine 9 (H3K9), a histone mark linked to gene repression
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Subjective stress and any drinking during alcohol treatment: Disentangling within and between person autoregressive effects Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-16 Katie Witkiewitz, Christian C. Garcia, Bengt O. Muthén
Alcohol use has been shown to increase stress, and there is some evidence that stress predicts subsequent alcohol use during treatment for alcohol use disorder (AUD), particularly among females who are more likely to report coping-motivated drinking. Gaining a better understanding of the processes by which stress and alcohol use are linked during treatment could potentially inform AUD treatment planning
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Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-15 Mikki Schantell, Brittany K. Taylor, Amirsalar Mansouri, Yasra Arif, Anna T. Coutant, Danielle L. Rice, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson
Psychosocial distress among youth is a major public health issue characterized by disruptions in cognitive control processing. Using the National Institute of Mental Health's Research Domain Criteria (RDoC) framework, we quantified multidimensional neural oscillatory markers of psychosocial distress serving cognitive control in youth. The sample consisted of 39 peri-adolescent participants who completed
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Prior experience with behavioral control over stress facilitates social dominance Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-06 Philip T. Coleman, Gabriel W. Costanza-Chavez, Heather N. Martin, Jose Amat, Matthew G. Frank, Rory J. Sanchez, Garrett J. Potter, Simone M. Mellert, Rene K. Carter, Gianni N. Bonnici, Steven F. Maier, Michael V. Baratta
Dominance status has extensive effects on physical and mental health, and an individual's relative position can be shaped by experiential factors. A variety of considerations suggest that the experience of behavioral control over stressors should produce winning in dominance tests and that winning should blunt the impact of later stressors, as does prior control. To investigate the interplay between
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Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-12-07 F. Benvenuti, S. De Carlo, L. Rullo, L. Caffino, L.M. Losapio, C. Morosini, M. Ubaldi, L. Soverchia, N. Cannella, E. Domi, S. Candeletti, F. Mottarlini, L. Fattore, P. Romualdi, F. Fumagalli, V. Trezza, M. Roberto, R. Ciccocioppo
Adverse early life experiences during postnatal development can evoke long-lasting neurobiological changes in stress systems, thereby affecting subsequent behaviors including propensity to develop alcohol use disorder. Here, we exposed genetically selected male and female Marchigian Sardinian alcohol-preferring (msP) and Wistar rats to mild, repeated social deprivation from postnatal day 14 (PND14)
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Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-25 Yuqi Wang, Yuchen Zhang, Jiawei Hu, Chengfang Pan, Yiming Gao, Qingzhuo Liu, Wendong Xu, Lei Xue, Changlong Hu
Glucocorticoids are primary stress hormones that exert neuronal effects via both genomic and non-genomic signaling pathways. However, their rapid non-genomic effects and underlying mechanisms on neural activities remain elusive. In the present study, we investigated the rapid non-genomic effect of glucocorticoids on Kv2.2 channels in cultured HEK293 cells and acute brain slices including cortical pyramidal
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Environmental enrichment reverses stress-induced changes in the brain-gut axis to ameliorate chronic visceral and somatic hypersensitivity Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-24 A. Orock, A.C. Johnson, E. Mohammadi, B. Greenwood-Van Meerveld
Introduction Behavioral therapies, including cognitive behavioral therapy, hypnotherapy and stress management activities, have emerged as effective treatments for irritable bowel syndrome (IBS), a female predominant disorder of the brain-gut axis. IBS, affecting over 10% of the global population, typically presents with abnormal bowel habits and abdominal pain due to visceral hypersensitivity. While
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Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-17 Robert H. Oakley, Natallia V. Riddick, Sheryl S. Moy, John A. Cidlowski
Many stress-related neuropsychiatric disorders display pronounced sex differences in their frequency and clinical symptoms. Glucocorticoids are primary stress hormones that have been implicated in the development of these disorders but whether they contribute to the observed sex bias is poorly understood. Glucocorticoids signal through two closely related nuclear receptors, the glucocorticoid (GR)
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Microglia are necessary for probiotics supplementation to improve impaired fear extinction caused by pregnancy stress in adult offspring of rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-19 Ru Zeng, Jie Chen, Yihan Peng, Weiye Xu, Yuanyuan Tao, Min Li, Ruqi Zhang, Jingzhuo Meng, Zhiyuan Li, Leping Zeng, Jufang Huang
The prevention and treatment of fear-related disorders in offspring affected by pregnancy stress remains challenging at clinic. Here, we examined the effects of gut microbiota of stressed pregnant rats on the fear extinction of their offsprings, and the potential mechanisms. We found that gut microbiota transplantation from rats with pregnancy stress to normal pregnant rats impaired fear extinction
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Association between gut microbiota and its functional metabolites with prenatal depression in women Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-17 Tianqu Xie, Xiaoxiao Fan, Hanghang Pang, Tianzi Zang, Ni Wu, Juan Liu, Ziying Li, Sha Li, Quanfei Zhu, Julia Elise Slack, Jinbing Bai, Yu Xu, Yanqun Liu
Background The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs). Methods
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The importance of REM sleep fragmentation in the effects of stress on sleep: Perspectives from preclinical studies Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-14 Laura Grafe, Katherine E. Miller, Richard J. Ross, Seema Bhatnagar
Psychological stress poses a risk for sleep disturbances. Importantly, trauma-exposed individuals who develop posttraumatic stress disorder (PTSD) frequently report insomnia and recurrent nightmares. Clinical studies have provided insight into the mechanisms of these sleep disturbances. We review polysomnographic findings in PTSD and identify analogous measures that have been made in animal models
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Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-10 Leonardo S. Novaes, Leticia M. Bueno-de-Camargo, Amadeu Shigeo-de-Almeida, Vitor A.L. Juliano, Ki Goosens, Carolina D. Munhoz
Anxiety, a state related to anticipatory fear, can be adaptive in the face of environmental threats or stressors. However, anxiety can also become persistent and manifest as anxiety- and stress-related disorders, such as generalized anxiety or post-traumatic stress disorder (PTSD). In rodents, systemic administration of glucocorticoids (GCs) or short-term restraint stress induces anxiety-like behaviors
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Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-07 Xianzong Meng, Ping Chen, Andor Veltien, Tony Palavra, Sjors In't Veld, Joanes Grandjean, Judith R. Homberg
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Controlling intrusive thoughts of future fears under stress Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-02 Stephanie M. Ashton, Tom Smeets, Conny W.E.M. Quaedflieg
Negative outlooks of our future may foster unwanted and intrusive thoughts. To some extent, individuals have control over their ability to suppress intrusions and downregulate their frequency. Acute stress impairs intentional suppression, leading to an increased frequency of intrusions. The aim of this study was to gain insight into the mechanism underlying stress-induced impairments in intentional
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Cortical volume alteration in the superior parietal region mediates the relationship between childhood abuse and PTSD avoidance symptoms: A complementary multimodal neuroimaging study Neurobiol. Stress (IF 5.0) Pub Date : 2023-11-07 Richard Okyere Nkrumah, Claudius von Schröder, Traute Demirakca, Christian Schmahl, Gabriele Ende
Background Adverse childhood experiences (ACE), which can be separated into abuse and neglect, contribute to the development of post-traumatic stress symptoms (PTSS). However, which brain structures are mainly affected by ACE as well as the mediating role these brain structures play in ACE and PTSS relationship are still being investigated. The current study tested the effect of ACE on brain structure
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The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-27 Jingjing Chang, Di Song, Rongjun Yu
The hippocampus has long been considered a pivotal region implicated in both stress susceptibility and resilience. A wealth of evidence from animal and human studies underscores the significance of hippocampal functional connectivity with the ventromedial prefrontal cortex (vmPFC) in these stress-related processes. However, there remains a scarcity of research that explores and contrasts the roles
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Acute stress selectively blunts reward anticipation but not consumption: An ERP study Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-27 Wei Yi, Yantao Chen, Linlin Yan, Nils Kohn, Jianhui Wu
Stress-induced dysfunction of reward processing is documented to be a critical factor associated with mental illness. Although many studies have attempted to clarify the relationship between stress and reward, few studies have investigated the effect of acute stress on the temporal dynamics of reward processing. The present study applied event-related potentials (ERP) to examine how acute stress differently
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Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-19 Cyprien G.J. Guerrin, Kavya Prasad, Daniel A. Vazquez-Matias, Jing Zheng, Maria Franquesa-Mullerat, Lara Barazzuol, Janine Doorduin, Erik F.J. de Vries
Maternal infection during pregnancy and childhood social trauma have been associated with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum disorders, bipolar disorder and depression. These disorders are characterized by changes in microglial cells, which play a notable role in synaptic pruning, and synaptic deficits. Here, we investigated the effect of prenatal infection
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High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-16 Qiang Wei, Vivek Kumar, Shannon Moore, Fei Li, Geoffrey G. Murphy, Stanley J. Watson, Huda Akil
Emotions are characterized not only by their valence but also by whether they are stable or labile. Yet, we do not understand the molecular or circuit mechanisms that control the dynamic nature of emotional responses. We have shown that glucocorticoid receptor overexpression in the forebrain (GRov) leads to a highly reactive mouse with increased anxiety behavior coupled with greater swings in emotional
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Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-15 John M. Felt, Natan Yusupov, Karra D. Harrington, Julia Fietz, Zhenyu “Zach” Zhang, Martin J. Sliwinski, Nilam Ram, Kieran J. O'Donnell, , Michael J. Meaney, Frank W. Putnam, Jennie G. Noll, Elisabeth B. Binder, Chad E. Shenk
Background Early life adversity and psychiatric disorders are associated with earlier declines in neurocognitive abilities during adulthood. These declines may be preceded by changes in biological aging, specifically epigenetic age acceleration, providing an opportunity to uncover genome-wide biomarkers that identify individuals most likely to benefit from early screening and prevention. Methods Five
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Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-06 Danique La Torre, Lukas Van Oudenhove, Tim Vanuytsel, Kristin Verbeke
An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and animal studies strongly suggest that psychosocial stress is one of the factors that can increase intestinal
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Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic Neurobiol. Stress (IF 5.0) Pub Date : 2023-10-01 Qingyuan Li, Xun Zhang, Xun Yang, Nanfang Pan, Xiao Li, Graham J. Kemp, Song Wang, Qiyong Gong
Background Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced during the coronavirus disease 2019 (COVID-19) pandemic. Little attention has been given to the neurobiological mechanisms underlying inter-individual differences in SA alterations related to COVID-19. This study aims to identify neurofunctional markers of COVID-specific
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Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-22 Diana Rodrigues, Patricia Monteiro
Chronic stress (CS) is a well-recognized triggering factor in obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS), two neuropsychiatric disorders characterized by the presence of stereotypic motor symptoms. Planning and execution of motor actions are controlled by the dorsal striatum, a brain region that promotes or suppresses motor movement by activating striatal neurons from the direct-
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Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-18 Shao-Han Chang, Yao-Ming Chang, Huan-Yuan Chen, Fu-Zen Shaw, Bai-Chuang Shyu
Posttraumatic stress disorder (PTSD) is a complex disorder that involves physiological, emotional, and cognitive dysregulation that may occur after exposure to a life-threatening event. In contrast with the condition of learned fear with resilience to extinction, abnormal fear with impaired fear extinction and exaggeration are considered crucial factors for the pathological development of PTSD. The
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The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-18 Miseon Kang, Jun-mo Chung, Jihyun Noh, Jeongyeon Kim
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Greater maltreatment severity is associated with smaller brain volume with implication for intellectual ability in young children Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-23 Judith Joseph, Claudia Buss, Andrea Knop, Karin de Punder, Sibylle M. Winter, Birgit Spors, Elisabeth Binder, John-Dylan Haynes, Christine Heim
Background Childhood maltreatment profoundly alters trajectories of brain development, promoting markedly increased long-term health risks and impaired intellectual development. However, the immediate impact of maltreatment on brain development in children and the extent to which altered global brain volume contributes to intellectual development in children with maltreatment experience is currently
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Effect of acetate supplementation on traumatic stress-induced behavioral impairments in male rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-19 Arax Tanelian, Bistra Nankova, Furong Hu, Jordan D. Sahawneh, Esther L. Sabban
Gut microbiota and their metabolites have emerged as key players in the pathogenesis of neuropsychiatric disorders. Recently, we demonstrated that animals susceptible to Single Prolonged Stress (SPS) have an overall pro-inflammatory gut microbiota and significantly lower cecal acetate levels than SPS-resilient rats, which correlated inversely with the anxiety index. Here, we investigated whether the
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Subcutaneous Mycobacterium vaccae ameliorates the effects of early life adversity alone or in combination with chronic stress during adulthood in male and female mice Neurobiol. Stress (IF 5.0) Pub Date : 2023-09-09 Giulia Mazzari, Christopher A. Lowry, Dominik Langgartner, Stefan O. Reber
Chronic psychosocial stress is a burden of modern society and poses a clear risk factor for a plethora of somatic and affective disorders, of which most are associated with an activated immune status and chronic low-grade inflammation. Preclinical and clinical studies further suggest that a failure in immunoregulation promotes an over-reaction of the inflammatory stress response and, thus, predisposes
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Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-26 Khalin E. Nisbett, Luis A. Gonzalez, Marina Teruel, C. Sue Carter, Leandro F. Vendruscolo, Michael E. Ragozzino, George F. Koob
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HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-19 Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M. Ku, Hongxing Zhang, Yuan Shen, Allyson K. Friedman, Ming-Hu Han
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in mediating ketamine's antidepressant effects. In this study, we directly targeted HCN channels
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Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-22 Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Chen
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Immersive virtual plus-maze to examine behavior and psychophysiological-related variables in young people with problematic alcohol and cannabis consumption Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-17 R.D. Moreno-Fernández, D. García-León, G. Peñas, R. Martín-Romero, F. Buades-Sitjar, P. Sampedro-Piquero
Stressful events appear to be risky situations that can precipitate the consumption of drugs. One way to recreate stressful contexts, in an ecological and controlled method, is through immersive virtual reality (VR). In our study, we designed the scenario of an elevated plus-maze (EPM) using VR, which is widely used in animal models to assess unconditioned anxiety. This task allowed us to analyze the
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Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-14 Erin Gorman-Sandler, Breanna Robertson, Jesseca Crawford, Gabrielle Wood, Archana Ramesh, Olufunke O. Arishe, R. Clinton Webb, Fiona Hollis
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Acute stress impairs visual path integration Neurobiol. Stress (IF 5.0) Pub Date : 2023-07-29 Osman Akan, Anne Bierbrauer, Nikolai Axmacher, Oliver T. Wolf
Acute stress exerts substantial effects on episodic memory, which are often mediated by glucocorticoids, the end-product of the hypothalamic-pituitary-adrenal axis. Surprisingly little is known, however, about the influence of acute stress on human spatial navigation. One specific navigational strategy is path integration, which is linked to the medial entorhinal cortex, a region harboring glucocorticoid
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Sex-dependent factors of alcohol and neuroimmune mechanisms Neurobiol. Stress (IF 5.0) Pub Date : 2023-08-03 Bryan Cruz, Vittoria Borgonetti, Michal Bajo, Marisa Roberto
Excessive alcohol use disrupts neuroimmune signaling across various cell types, including neurons, microglia, and astrocytes. The present review focuses on recent, albeit limited, evidence of sex differences in biological factors that mediate neuroimmune responses to alcohol and underlying neuroimmune systems that may influence alcohol drinking behaviors. Females are more vulnerable than males to the
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Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample Neurobiol. Stress (IF 5.0) Pub Date : 2023-07-21 Terrell D. Holloway, Zachary M. Harvanek, Ke Xu, Derrick M. Gordon, Rajita Sinha
Black Americans suffer lower life expectancy and show signs of accelerated aging compared to other Americans. While previous studies observe these differences in children and populations with chronic illness, whether these pathologic processes exist or how these pathologic processes progress has yet to be explored prior to the onset of significant chronic illness, within a young adult population. Therefore