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Differential contributions of body form, motion, and temporal information to subjective action understanding in naturalistic stimuli Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-03-12 Vojtěch Smekal, Marta Poyo Solanas, Evelyne I. C. Fraats, Beatrice de Gelder
IntroductionWe investigated the factors underlying naturalistic action recognition and understanding, as well as the errors occurring during recognition failures.MethodsParticipants saw full-light stimuli of ten different whole-body actions presented in three different conditions: as normal videos, as videos with the temporal order of the frames scrambled, and as single static representative frames
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Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-02-19 María Alejandra González-González, Silvia V. Conde, Ramon Latorre, Stéphanie C. Thébault, Marta Pratelli, Nicholas C. Spitzer, Alexei Verkhratsky, Marie-Ève Tremblay, Cuneyt G. Akcora, Ana G. Hernández-Reynoso, Melanie Ecker, Jayme Coates, Kathleen L. Vincent, Brandy Ma
Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive clinical benefits, alongside unique challenges. It consists of the modulation of the nervous system by precise delivery of electrical current for the treatment of clinical conditions, such as post-stroke movement recovery or drug-resistant disorders. The unquestionable clinical impact of Bioelectronic Medicine
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Object-oriented hand dexterity and grasping abilities, from the animal quarters to the neurosurgical OR: a systematic review of the underlying neural correlates in non-human, human primate and recent findings in awake brain surgery Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-02-15 Leonardo Tariciotti, Luca Mattioli, Luca Viganò, Matteo Gallo, Matteo Gambaretti, Tommaso Sciortino, Lorenzo Gay, Marco Conti Nibali, Alberto Gallotti, Gabriella Cerri, Lorenzo Bello, Marco Rossi
IntroductionThe sensorimotor integrations subserving object-oriented manipulative actions have been extensively investigated in non-human primates via direct approaches, as intracortical micro-stimulation (ICMS), cytoarchitectonic analysis and anatomical tracers. However, the understanding of the mechanisms underlying complex motor behaviors is yet to be fully integrated in brain mapping paradigms
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Motor imagery in autism: a systematic review Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-02-12 Emma Gowen, Eve Edmonds, Ellen Poliakoff
IntroductionMotor Imagery (MI) is when an individual imagines performing an action without physically executing that action and is thought to involve similar neural processes used for execution of physical movement. As motor coordination difficulties are common in autistic individuals it is possible that these may affect MI ability. The aim of this systematic review was to assess the current knowledge
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Autosomal recessive cerebellar ataxias: a diagnostic classification approach according to ocular features Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-02-07 Diego Lopergolo, Francesca Rosini, Elena Pretegiani, Alessia Bargagli, Valeria Serchi, Alessandra Rufa
Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of neurodegenerative disorders affecting primarily the cerebellum and/or its afferent tracts, often accompanied by damage of other neurological or extra-neurological systems. Due to the overlap of clinical presentation among ARCAs and the variety of hereditary, acquired, and reversible etiologies that can determine cerebellar
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Neurophysiological markers of asymmetric emotional contagion: implications for organizational contexts Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-01-30 Sarah Boukarras, Donato Ferri, Laura Borgogni, Salvatore Maria Aglioti
Emotions play a vital role within organizations, impacting various crucial aspects of work such as job satisfaction, performance, and employee well-being. Understanding how emotional states spread in organizational settings is therefore essential. Recent studies have highlighted that a leader’s emotional state can influence their followers, with significant consequences on job performance. Leaders
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Infants on the move: bibliometric analyses of observational vs. digital means of screening infant development Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-01-25 Hannah Varkey, Ha Phan, Phyllis Kittler, Anne Gordon, Elizabeth B. Torres
Neurodevelopmental disorders are on the rise, yet their average diagnosis is after 4.5 years old. This delay is partly due to reliance on social-communication criteria, which require longer maturation than scaffolding elements of neuromotor control. Much earlier criteria could include reflexes, monitoring of the quality of spontaneous movements from central pattern generators and maturation of intentional
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Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-01-17 Barbara Nikolic, Sara Trnski-Levak, Kristina Kosic, Matea Drlje, Ivan Banovac, Dubravka Hranilovic, Natasa Jovanov-Milosevic
IntroductionAdversities during the perinatal period can decrease oxygen supply to the fetal brain, leading to various hypoxic brain injuries, which can compromise the regularity of brain development in different aspects. To examine the catecholaminergic contribution to the link between an early-life hypoxic insult and adolescent behavioral aberrations, we used a previously established rat model of
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Intrinsic functional clustering of the macaque insular cortex Front. Integr. Neurosci. (IF 3.5) Pub Date : 2024-01-05 Lotte Sypré, Saloni Sharma, Dante Mantini, Koen Nelissen
The functional organization of the primate insula has been studied using a variety of techniques focussing on regional differences in either architecture, connectivity, or function. These complementary methods offered insights into the complex organization of the insula and proposed distinct parcellation schemes at varying levels of detail and complexity. The advent of imaging techniques that allow
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Brain morphological variability between whites and African Americans: the importance of racial identity in brain imaging research Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-12-21 Daniel Atilano-Barbosa, Fernando A. Barrios
In a segregated society, marked by a historical background of inequalities, there is a consistent under-representation of ethnic and racial minorities in biomedical research, causing disparities in understanding genetic and acquired diseases as well as in the effectiveness of clinical treatments affecting different groups. The repeated inclusion of small and non-representative samples of the population
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Potential uses of auditory nerve stimulation to modulate immune responses in the inner ear and auditory brainstem Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-12-14 Benjamin J. Seicol, Zixu Guo, Katy Garrity, Ruili Xie
Bioelectronic medicine uses electrical stimulation of the nervous system to improve health outcomes throughout the body primarily by regulating immune responses. This concept, however, has yet to be applied systematically to the auditory system. There is growing interest in how cochlear damage and associated neuroinflammation may contribute to hearing loss. In conjunction with recent findings, we propose
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Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-12-07 Angela D. Friederici, Roman M. Wittig, Alfred Anwander, Cornelius Eichner, Tobias Gräßle, Carsten Jäger, Evgeniya Kirilina, Ilona Lipp, Ariane Düx, Luke J. Edwards, Cédric Girard-Buttoz, Anna Jauch, Kathrin S. Kopp, Michael Paquette, Kerrin J. Pine, Steve Unwin, Daniel B. M. Haun, Fabian H. Leendertz, Richard McElreath, Markus Morawski, Philipp Gunz, Nikolaus Weiskopf, Catherine Crockford, EBC Consortium
To decipher the evolution of the hominoid brain and its functions, it is essential to conduct comparative studies in primates, including our closest living relatives. However, strong ethical concerns preclude in vivo neuroimaging of great apes. We propose a responsible and multidisciplinary alternative approach that links behavior to brain anatomy in non-human primates from diverse ecological backgrounds
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The Moralizing Effect: self-directed emotions and their impact on culpability attributions Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-11-28 Elisabetta Sirgiovanni, Joanna Smolenski, Ben Abelson, Taylor Webb
IntroductionA general trend in the psychological literature suggests that guilt contributes to morality more than shame does. Unlike shame-prone individuals, guilt-prone individuals internalize the causality of negative events, attribute responsibility in the first person, and engage in responsible behavior. However, it is not known how guilt- and shame-proneness interact with the attribution of responsibility
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Neuronal activity in posterior parietal cortex area LIP is not sufficient for saccadic eye movement production Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-11-24 Emiliano Brunamonti, Martin Paré
It is widely recognized that the posterior parietal cortex (PPC) plays a role in active exploration with eye movements, arm reaching, and hand grasping. Whether this role is causal in nature is largely unresolved. One region of the PPC appears dedicated to the control of saccadic eye movement—lateral intraparietal (LIP) area. This area LIP possesses direct projections to well-established oculomotor
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The effect of acupuncture at the Taiyang acupoint on visual function and EEG microstates in myopia Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-11-15 Kangna Su, Lihan Wang, Zhongqing Wang, Jiayao Ma, Chao Zhang, Hongsheng Bi, Jianfeng Wu
ObjectiveAcupuncture has certain effects to improve myopia visual function, but its neural mechanism is unclear. In this study, we acupunctured at the right Taiyang acupoint of myopic patients to analyze the effects of acupuncture on visual function and electroencephalographic activity and to investigate the correlation between improvements in visual function and changes in the brain.MethodsIn this
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Altered gait parameters in distracted walking: a bio-evolutionary and prognostic health perspective on passive listening and active responding during cell phone use Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-11-13 Hassan Bazzi, Anthony T. Cacace
The underpinnings of bipedal gait are reviewed from an evolutionary biology and prognostic health perspective to better understand issues and concerns related to cell phone use during ambulation and under conditions of distraction and interference. We also consider gait-related health issues associated with the fear of or risk of falling and include prognostic dimensions associated with cognitive decline
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The impact of early life stress and schizophrenia on motor and cognitive functioning: an experimental study Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-19 Fredrick Otieno Oginga, Thabisile Mpofana
BackgroundEarly life stress (ELS) and parental psychopathology, such as schizophrenia (SZ), have been associated with altered neurobiological and behavioral outcomes later in life. Previous studies have investigated the effects of ELS and parental SZ on various aspects of behavior, however, we have studied the combined effects of these stressors and how they interact, as individuals in real-life situations
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Gradients of thalamic connectivity in the macaque lateral prefrontal cortex Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-16 Elena Borra, Marianna Rizzo, Giuseppe Luppino
In the primate brain, the lateral prefrontal cortex (LPF) is a large, heterogeneous region critically involved in the cognitive control of behavior, consisting of several connectionally and functionally distinct areas. Studies in macaques provided evidence for distinctive patterns of cortical connectivity between architectonic areas located at different dorsoventral levels and for rostrocaudal gradients
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Electrical stimulation of the auricular branch of the vagus nerve potentiates analgesia induced by physical exercise in mice with peripheral inflammation Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-12 Aline Raulino Dutra, Daiana Cristina Salm, Rafaela Hardt da Silva, Fernanda Tanaka, Daniela Dero Lutdke, Bruna Hoffmann de Oliveira, Rose Lampert, Edsel B. Bittencourt, Gianluca Bianco, Vinícius M. Gadotti, William R. Reed, Josiel Mileno Mack, Franciane Bobinski, Ari O. O. Moré, Daniel Fernandes Martins
ObjectiveThis study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous vagus nerve electrical stimulation (pVNS) associated with physical exercise, i.e., swimming, in mice with peripheral inflammation.MethodsThe pain model was induced by intraplantar (i.pl.) injection of Freund’s complete adjuvant (CFA). Sixty-four male Swiss mice (35–40 g) received an i.pl. of CFA and underwent
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No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-06 Katy Tarrit, Edward G. Freedman, Ana A. Francisco, Douwe J. Horsthuis, Sophie Molholm, John J. Foxe
BackgroundAltered patterns of eye-movements during scene exploration, and atypical gaze preferences in social settings, have long been noted as features of the Autism phenotype. While these are typically attributed to differences in social engagement and interests (e.g., preferences for inanimate objects over face stimuli), there are also reports of differential saccade measures to non-social stimuli
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Editorial: Bridging the gap between integrative neuroscience and translational neuroscience. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-05 Elias Manjarrez,Giulia Curia,Katinka Stecina,Alejandro Lopez Valdes
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Peripheral vestibular loss in noise-exposed firefighters Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-10-03 Hillary Anne Snapp, Lindsey Vanlooy, Brianna Kuzbyt, Courtney Kolberg, Denise Laffitte-Lopez, Suhrud Rajguru
IntroductionOccupational workers are increasingly aware of the risk of noise overexposure to the auditory system but lack awareness about potential risks to the vestibular system. The purpose of this study was to investigate changes in vestibular end organ function in a known at-risk noise-exposed population, firefighters compared to age- and sex-matched controls using electrophysiologic measures of
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Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-09-14 Cristina Carresi, Antonio Cardamone, Anna Rita Coppoletta, Annachiara Mollace, Vincenzo Musolino, Micaela Gliozzi, Vincenzo Mollace
Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases
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A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-09-05 Federica M. Raciti, Yasniary Morales, Hillary A. Snapp, Suhrud M. Rajguru
IntroductionCervical vestibular evoked myogenic potentials (cVEMPs) provide an objective measure of the integrity of the sacculo-collic pathway leading to their widespread use as a clinical tool in the diagnostic vestibular test battery. Though the application of cVEMPs in preclinical models to assess vestibular function, as performed in relevant clinical populations, remains limited. The present study
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Pupil light reflex dynamics in Parkinson’s disease Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-31 Panagiota Tsitsi, Mattias Nilsson, Josefine Waldthaler, Gustaf Öqvist Seimyr, Olof Larsson, Per Svenningsson, Ioanna Markaki
IntroductionVisual disturbance is common symptom in Parkinson’s disease (PD), and defective pupil light reflex (PLR) is an anticipated contributing factor that may be associated to the presence of autonomic dysfunction, which is a common non-motor feature of PD. Studies investigating the intercorrelation between PLR and dysautonomia in PD are limited.MethodsThe aim of this study was to investigate
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Post-activation depression of the Hoffman reflex is not altered by galvanic vestibular stimulation in healthy subjects Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-31 Mónica del Carmen Alvarado-Navarrete, Adriana C. Pliego-Carrillo, Claudia Ivette Ledesma-Ramírez, Carlos A. Cuellar
The comprehension of the neural elements interacting in the spinal cord affected by vestibular input will contribute to the understanding of movement execution in normal and pathological conditions. In this context, Hoffman’s reflex (H-reflex) has been used to evaluate transient excitability changes on the spinal cord descending pathways. The post-activation depression (P-AD) of the H-reflex consists
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Interpreting the meaning of changes in hippocampal volume associated with vestibular loss Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-07 Paul F. Smith
Many studies have documented cognitive deficits, especially spatial cognitive deficits, in patients with some form of vestibular loss. Almost 20 years ago, hippocampal (HPC) atrophy was reported to be correlated with spatial memory deficits in such patients and the idea has gradually emerged that HPC atrophy may be causally responsible for the cognitive deficits. However, the results of studies of
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The time is ripe for the renaissance of autism treatments: evidence from clinical practitioners Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-04 Elizabeth B. Torres, Goldie Twerski, Hannah Varkey, Richa Rai, Mona Elsayed, Miriam Tirtza Katz, Jillian Tarlowe
IntroductionRecent changes in diagnostics criteria have contributed to the broadening of the autism spectrum disorders and left clinicians ill-equipped to treat the highly heterogeneous spectrum that now includes toddlers and children with sensory and motor issues.MethodsTo uncover the clinicians’ critical needs in the autism space, we conducted surveys designed collaboratively with the clinicians
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Touch may reduce cognitive load during assisted typing by individuals with developmental disabilities Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-03 Giovanni Nicoli, Giulia Pavon, Andrew Grayson, Anne Emerson, Suvobrata Mitra
Many techniques have attempted to provide physical support to ease the execution of a typing task by individuals with developmental disabilities (DD). These techniques have been controversial due to concerns that the support provider’s touch can influence the typed content. The most common interpretation of assisted typing as an ideomotor phenomenon has been qualified recently by studies showing that
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Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-08-02 Daniel L. Cooke, Hui Shen, Madhavi Duvvuri, Daniel Thompson, Thomas Neylan, William Wolfe, Steven Hetts, Bruce Ovbiagele, Mary Whooley, Beth Cohen
BackgroundBrain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH.MethodsWe performed retrospective, case-control study of a National Veterans Affairs population with two experimental groups
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Editorial: Neural markers of sensory processing in development. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-07-21 Lauren E Ethridge,Benjamin D Auerbach,Anis Contractor,Iryna M Ethell,Elizabeth A McCullagh,Ernest V Pedapati
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Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-07-18 Yingjing Xia, Vida Rebello, Stefanie C. Bodison, Deborah Jonker, Babette Steigelmann, Kirsten A. Donald, Weslin Charles, Dan J. Stein, Jonathan Ipser, Hedyeh Ahmadi, Eric Kan, Elizabeth R. Sowell, Katherine L. Narr, Shantanu H. Joshi, Hein J. Odendaal, Kristina A. Uban
BackgroundAlcohol and tobacco are known teratogens. Historically, more severe prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) have been examined as the principal predictor of neurodevelopmental alterations, with little incorporation of lower doses or ecological contextual factors that can also impact neurodevelopment, such as socioeconomic resources (SER) or adverse childhood experiences
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Balance beam crossing times are slower after noise exposure in rats Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-07-11 Dylan Bartikofsky, Mikayla Jade Hertz, David S. Bauer, Richard Altschuler, W. Michael King, Courtney Elaine Stewart
IntroductionThe vestibular system integrates signals related to vision, head position, gravity, motion, and body position to provide stability during motion through the environment. Disruption in any of these systems can reduce agility and lead to changes in ability to safely navigate one’s environment. Causes of vestibular decline are diverse; however, excessive noise exposure can lead to otolith
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Visuo-spatial imagery in dreams of congenitally and early blind: a systematic review Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-30 Katarina Ilic, Rita Bertani, Neda Lapteva, Panagis Drakatos, Alessio Delogu, Kausar Raheel, Matthew Soteriou, Carlotta Mutti, Joerg Steier, David W. Carmichael, Peter J. Goadsby, Adam Ockelford, Ivana Rosenzweig
BackgroundThe presence of visual imagery in dreams of congenitally blind people has long been a matter of substantial controversy. We set to systematically review body of published work on the presence and nature of oneiric visuo-spatial impressions in congenitally and early blind subjects across different areas of research, from experimental psychology, functional neuroimaging, sensory substitution
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Editorial: The effect of gut microbiota on the brain structure and function. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-29 Shan Liang,Feng Jin,Chenxi Jia
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Urinary TNF-α as a potential biomarker for chronic primary low back pain Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-28 Carlos Gevers-Montoro, Mariana Puente-Tobares, Aléxiane Monréal, Francisco Miguel Conesa-Buendía, Mathieu Piché, Arantxa Ortega-De Mues
IntroductionOver two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain
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Understanding the neural bases of bodily self-consciousness: recent achievements and main challenges Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-19 Zoé Dary, Christophe Lopez
The last two decades have seen a surge of interest in the mechanisms underpinning bodily self-consciousness (BSC). Studies showed that BSC relies on several bodily experiences (i.e., self-location, body ownership, agency, first-person perspective) and multisensory integration. The aim of this literature review is to summarize new insights and novel developments into the understanding of the neural
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Toward reproducible models of sequence learning: replication and analysis of a modular spiking network with reward-based learning Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-15 Barna Zajzon, Renato Duarte, Abigail Morrison
To acquire statistical regularities from the world, the brain must reliably process, and learn from, spatio-temporally structured information. Although an increasing number of computational models have attempted to explain how such sequence learning may be implemented in the neural hardware, many remain limited in functionality or lack biophysical plausibility. If we are to harvest the knowledge within
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Editorial: Rising stars in integrative neuroscience 2021. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-14 Giuseppina Porciello,Lucia Maria Sacheli
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Spatiotemporal phase slip patterns for visual evoked potentials, covert object naming tasks, and insight moments extracted from 256 channel EEG recordings Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-13 Ceon Ramon, Uwe Graichen, Paolo Gargiulo, Frank Zanow, Thomas R. Knösche, Jens Haueisen
Phase slips arise from state transitions of the coordinated activity of cortical neurons which can be extracted from the EEG data. The phase slip rates (PSRs) were studied from the high-density (256 channel) EEG data, sampled at 16.384 kHz, of five adult subjects during covert visual object naming tasks. Artifact-free data from 29 trials were averaged for each subject. The analysis was performed to
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Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-06-12 Vinícius Fresca da Costa, Johana Caterin Caipa Ramírez, Stephany Viatela Ramírez, Julian Humberto Avalo-Zuluaga, Daniela Baptista-de-Souza, Lucas Canto-de-Souza, Cleopatra S. Planeta, Javier Leonardo Rico Rodríguez, Ricardo Luiz Nunes-de-Souza
IntroductionChronic exposure to social defeat stress (SDS) has been used to investigate the neurobiology of depressive- and anxiety-like responses and mnemonic processes. We hypothesized that these affective, emotional, and cognitive consequences induced by SDS are regulated via glutamatergic neurons located in the bed nucleus of the stria terminalis (BNST), amygdaloid complex, and hippocampus in mice
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The brain in motion–cognitive effects of simultaneous motor activity Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-05-25 Maren Schmidt-Kassow, Jochen Kaiser
During the last 30 years, a large number of behavioral studies have investigated the effect of simultaneous exercise on cognitive functions. The heterogeneity of the results has been attributed to different parameters, such as intensity or modality of physical activity, and the investigated cognitive processes. More recent methodological improvements have enabled to record electroencephalography (EEG)
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Vestibular prosthesis: from basic research to clinics Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-05-17 Enrique Soto, Adriana Pliego, Rosario Vega
Balance disorders are highly prevalent worldwide, causing substantial disability with high personal and socioeconomic impact. The prognosis in many of these patients is poor, and rehabilitation programs provide little help in many cases. This medical problem can be addressed using microelectronics by combining the highly successful cochlear implant experience to produce a vestibular prosthesis, using
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The brain is not mental! coupling neuronal and immune cellular processing in human organisms Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-05-17 Anna Ciaunica, Evgeniya V. Shmeleva, Michael Levin
Significant efforts have been made in the past decades to understand how mental and cognitive processes are underpinned by neural mechanisms in the brain. This paper argues that a promising way forward in understanding the nature of human cognition is to zoom out from the prevailing picture focusing on its neural basis. It considers instead how neurons work in tandem with other type of cells (e.g.
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Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-05-15 Isabelle F. Witteveen, Emily McCoy, Troy D. Holsworth, Catherine Z. Shen, Winnie Chang, Madelyn G. Nance, Allison R. Belkowitz, Avery Dougald, Meghan H. Puglia, Adema Ribic
Prematurity is among the leading risks for poor neurocognitive outcomes. The brains of preterm infants show alterations in structure and electrical activity, but the underlying circuit mechanisms are unclear. To address this, we performed a cross-species study of the electrophysiological activity in the visual cortices of prematurely born infants and mice. Using electroencephalography (EEG) in a sample
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Factors influencing the relationship between cochlear health measures and speech recognition in cochlear implant users Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-05-12 Ladan Zamaninezhad, Berkutay Mert, Heval Benav, Jochen Tillein, Carolyn Garnham, Uwe Baumann
BackgroundOne factor which influences the speech intelligibility of cochlear implant (CI) users is the number and the extent of the functionality of spiral ganglion neurons (SGNs), referred to as “cochlear health.” To explain the interindividual variability in speech perception of CI users, a clinically applicable estimate of cochlear health could be insightful. The change in the slope of the electrically
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Systems Thinking in an era of climate change: Does cognitive neuroscience hold the key to improving environmental decision making? A perspective on Climate-Smart Agriculture Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-27 Baqir Lalani, Steven Gray, Tora Mitra-Ganguli
Systems Thinking (ST) can be defined as a mental construct that recognises patterns and connections in a particular complex system to make the “best decision” possible. In the field of sustainable agriculture and climate change, higher degrees of ST are assumed to be associated with more successful adaptation strategies under changing conditions, and “better” environmental decision making in a number
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Bridging event-related potentials with behavioral studies in motor learning Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-24 Xueqian Deng, Chen Yang, Jingyue Xu, Mengzhan Liufu, Zina Li, Juan Chen
Behavioral approaches and electrophysiology in understanding human sensorimotor systems have both yielded substantial advancements in past decades. In fact, behavioral neuroscientists have found that motor learning involves the two distinct processes of the implicit and the explicit. Separately, they have also distinguished two kinds of errors that drive motor learning: sensory prediction error and
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A call to leverage a health equity lens to accelerate human neuroscience research Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-17 Vida Rebello, Kristina A. Uban
Investigation of health inequities tend to be examined, in human neurosciences, as biological factors at the level of the individual. In actuality, health inequities arise, due largely in part, to deep-seated structural factors. Structural inequality refers to the systemic disadvantage of one social group compared to others with whom they coexist. The term encompasses policy, law, governance, and culture
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Functional and structural readouts for early detection of retinal involvement in multiple sclerosis Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-17 Khaldoon O. Al-Nosairy, Alexander Duscha, Henrike Buhr, Antonia Lipp, Christiane Desel, Tobias Hegelmaier, Hagen Thieme, Aiden Haghikia, Michael B. Hoffmann
IntroductionThe retina, a window into the brain, allows for the investigation of many disease-associated inflammatory and neurodegenerative changes affecting the central nervous system (CNS). Multiple sclerosis (MS), an autoimmune disease targeting the CNS, typically impacts on the visual system including the retina. Hence, we aimed to establish innovative functional retinal measures of MS-related
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Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-17 Prangya Parimita Sahu, Philip Tseng
Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer’s
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Editorial: Mind-body medicine and its impacts on psychological networks, quality of life, and health. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-04 Steffen Schulz,Dirk Cysarz,Georg Seifert
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The cost of aiming for the best answers: Inconsistent perception Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-04-03 Jeroen B. J. Smeets, Eli Brenner
The laws of physics and mathematics describe the world we live in as internally consistent. As these rules provide a very effective description, and our interaction with the world is also very effective, it seems self-evident that our perception follows these laws. As a result, when trying to explain imperfections in perception, we tend to impose consistency and introduce concepts such as deformations
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Editorial: Noise-induced hearing loss: From basic to clinical research. Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-17 Zhiwu Huang,Wei Qiu,Vicky Zhang,Hui Wang,Bin Ye,Qixuan Wang
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Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-16 Yuqian Wang, Jing Zhu, Ning Zou, Li Zhang, Yingjie Wang, Mengmeng Zhang, Chan Wang, Liu Yang
White matter injury (WMI) in premature infants is a unique form of brain injury and a common cause of chronic nervous system conditions such as cerebral palsy and neurobehavioral disorders. Very preterm infants who survive are at high risk of WMI. With developing research regarding the pathogenesis of premature WMI, the role of gut microbiota has attracted increasing attention in this field. As premature
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From circuits to behavior: Amygdala dysfunction in fragile X syndrome Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-09 Matthew N. Svalina, Regina Sullivan, Diego Restrepo, Molly M. Huntsman
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the FMR1 gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early development of the brain. Thus, loss of the FMRP has well-known consequences for normal cellular and synaptic
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Gender diversity associated with patterns of brain activation seen in populations that experience childhood stress Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-09 Hannah Loso, Bader Chaarani, Sarahjane Locke Dube, Matthew D. Albaugh, Aya Cheaito, Hugh Garavan, Alexandra Potter
IntroductionStressful childhood experiences are associated with unique brain activity patterns during emotional processing. Specifically, pediatric stress is linked to activation in the insulae, superior temporal and parahippocampal gyri, and the amygdalae, as well as differential activation in the dorsal anterior cingulate cortex when viewing emotional faces. Gender diversity is broadly associated
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Remembrance of things perceived: Adding thalamocortical function to artificial neural networks Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-07 Gerald E. Loeb
Recent research has illuminated the complexity and importance of the thalamocortical system but it has been difficult to identify what computational functions it performs. Meanwhile, deep-learning artificial neural networks (ANNs) based on bio-inspired models of purely cortical circuits have achieved surprising success solving sophisticated cognitive problems associated historically with human intelligence
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Case report: Novel mutations in the SPG11 gene in a case of autosomal recessive hereditary spastic paraplegia with a thin corpus callosum Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-06 Ji-Qing Duan, Hui Liu, Jia-Qiao Wu
A 24-year-old man presented with insidious onset progressive gait disturbance and was finally diagnosed with autosomal recessive hereditary spastic paraplegia. Two novel mutations, including a frameshift mutation (c.5687_5691del) and a non-sense mutation (c.751C>T), were identified in the SPG11 gene of the patient through whole genome sequencing. The frameshift mutation of c.5687_5691del leads to a
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Reduced eye optical quality contributes to worse chromatic thresholds in aging Front. Integr. Neurosci. (IF 3.5) Pub Date : 2023-03-06 Marcelo Fernandes Costa, Livia Soledade Rego, Leonardo Dutra Henriques, Carlo Martins Gaddi, Givago Silva Souza
Purpose Aging causes substantial changes in the intraocular lens, which leads to a reduction in chromatic perception. We aimed to measure the ocular light dispersion component in relation to the reduction in color vision by aging. Methods Intraocular straylight was quantified psychophysically by C-Quant for light dispersion [Log(s)], reliability of the results (ESD), and psychometric sampling quality