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Validation of the German Version of the New Freezing of Gait Questionnaire for People with Parkinson‘s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2021-01-13 Jana Seuthe; Kristina Kuball; Ann-Kristin Hoffmann; Burkhard Weisser; Günther Deuschl; Christian Schlenstedt
Freezing of gait (FOG) in Parkinson’s disease (PD) is a highly disabling symptom which impacts quality of life. The New FOG Questionnaire (NFOG-Q) is the most commonly used tool worldwide to characterize FOG severity in PD. This study aims to provide a German translation of the NFOG-Q and to assess its validity in people with PD. The questionnaire was translated using forward-backward translation.
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Freezing of Gait in Parkinson’s Disease: Risk Factors, Their Interactions, and Associated Nonmotor Symptoms Parkinson's Dis. (IF 1.758) Pub Date : 2021-01-12 David Gordon Lichter; Ralph Holmes Boring Benedict; Linda Ann Hershey
Background. Freezing of gait (FOG) is a debilitating and incompletely understood symptom in Parkinson’s disease (PD). Objective. To determine the principal clinical factors predisposing to FOG in PD, their interactions, and associated nonmotor symptoms. Methods. 164 PD subjects were assessed in a cross-sectional retrospective study, using the MDS-UPDRS scale, MMSE, and Clinical Dementia Rating Scale
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Social Cognition in Patients with Early-Onset Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2021-01-08 Ana Natalia Seubert-Ravelo; Ma Guillermina Yáñez-Téllez; María Lizbeth Lazo-Barriga; Alejandra Calderón Vallejo; Carlos Eduardo Martínez-Cortés; Adela Hernández-Galván
Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial emotion, theory of mind (ToM), and decision-making domains, with limited research reporting on social reasoning
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Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice Parkinson's Dis. (IF 1.758) Pub Date : 2021-01-04 Khashayar Dashtipour; Fiona Gupta; Robert A. Hauser; Cherian A. Karunapuzha; John C. Morgan
Background. Parkinson’s disease psychosis (PDP) is a common, nonmotor symptom of Parkinson’s disease (PD), which may affect up to 60% of patients and is associated with impaired quality of life, increased healthcare costs, and nursing home placement, among other adverse outcomes. Characteristic symptoms of PDP include illusions; visual, auditory, tactile, and olfactory hallucinations; and delusions
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Social Symptoms of Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-12-31 Margaret T. M. Prenger; Racheal Madray; Kathryne Van Hedger; Mimma Anello; Penny A. MacDonald
Parkinson’s disease (PD) is typically well recognized by its characteristic motor symptoms (e.g., bradykinesia, rigidity, and tremor). The cognitive symptoms of PD are increasingly being acknowledged by clinicians and researchers alike. However, PD also involves a host of emotional and communicative changes which can cause major disruptions to social functioning. These incude problems producing emotional
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo Parkinson's Dis. (IF 1.758) Pub Date : 2020-12-30 Chien-Wei Feng; Nan-Fu Chen; Te-Fu Chan; Wu-Fu Chen
Parkinson’s disease (PD) is one of the most widespread neurodegenerative diseases. However, the currently available treatments could only relieve symptoms. Novel therapeutic targets are urgently needed. Several previous studies mentioned that protein tyrosine phosphatase 1B (PTP1B) acted as a negative regulator of the insulin signal pathway and played a significant role in the inflammation process
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Autonomic Dysfunctions in Parkinson’s Disease: Prevalence, Clinical Characteristics, Potential Diagnostic Markers, and Treatment Parkinson's Dis. (IF 1.758) Pub Date : 2020-12-24 Zhe Zhang; Sheng-Di Chen
Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and the elderly. Symptoms of autonomic dysfunctions are frequently seen in PD patients, severely affecting the quality of life. This review summarizes the epidemiology, clinical manifestations, and treatment options of autonomic dysfunctions. The clinical significance of autonomic dysfunctions in PD early diagnosis and
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Self-Management Components as Experienced by People with Parkinson’s Disease and Their Carers: A Systematic Review and Synthesis of the Qualitative Literature Parkinson's Dis. (IF 1.758) Pub Date : 2020-12-15 Remco Tuijt; Aylin Tan; Megan Armstrong; Jennifer Pigott; Joy Read; Nathan Davies; Kate Walters; Anette Schrag
Background. Self-management strategies are important in healthcare for people with Parkinson’s to improve daily living. There is limited evidence on effectiveness in Parkinson’s, and the active components of effective self-management strategies are uncertain. This review aims to identify and synthesise the qualitative evidence regarding the experiences of self-management components by people with Parkinson’s
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Development and Initial Validation of the Chinese Version of the Florida Surgical Questionnaire for Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-12-12 Tao Wang; Yiwang Zhang; Yixin Pan; Linbin Wang; Chencheng Zhang; Jun Liu; Liuguan Bian; Bomin Sun; Dianyou Li
Background. Deep brain stimulation (DBS) for Parkinson’s disease (PD) has evolved as a well-established treatment in neurosurgery, and identifying appropriate surgical candidates could contribute to better DBS outcomes. The Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD) is a reasonable screening tool for assessing DBS candidacy in PD patients; however, a Chinese version of FLASQ-PD
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Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-11-28 Jing Wang; Ruihua Cao; Tao Huang; Cheng Liu; Yidong Fan
The aim of the present study was to determine the relation between urinary dysfunction and nigrostriatal dopaminergic degeneration in early and untreated Parkinson’s disease (PD). The data were obtained from Parkinson’s Progression Markers Initiative database. Two hundred and seventy-five patients and 149 healthy controls were included in our analysis. Urinary symptoms were evaluated with the Scale
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Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial Parkinson's Dis. (IF 1.758) Pub Date : 2020-11-30 Elke Kalbe; Ann-Kristin Folkerts; Anja Ophey; Carsten Eggers; Saskia Elben; Karina Dimenshteyn; Patricia Sulzer; Claudia Schulte; Nele Schmidt; Christian Schlenstedt; Daniela Berg; Karsten Witt; Lars Wojtecki; Inga Liepelt-Scarfone
Background. Meta-analyses have demonstrated cognitive training (CT) benefits in Parkinson’s disease (PD) patients. However, the patients’ cognitive status has only rarely been based on established criteria. Also, prediction analyses of CT success have only sparsely been conducted. Objective. To determine CT effects in PD patients with mild cognitive impairment (PD-MCI) on cognitive and noncognitive
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Prescription of Anticholinergics in Tardive Syndromes: A “Dual Center” Survey among Psychiatrists Parkinson's Dis. (IF 1.758) Pub Date : 2020-11-23 Anna Cutino; Roongroj Bhidayasiri; Carlo Colosimo
Background and Objectives. Anticholinergics have been proposed in the therapy of tardive syndromes since the early 60 s, despite only anecdotal reports of a positive effect and a lack of sound evidence supporting their usefulness. Methods. We assessed the attitude of two groups of psychiatrists (practicing in Italy and Thailand) towards the prescription of anticholinergics by a short online survey
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Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist Parkinson's Dis. (IF 1.758) Pub Date : 2020-11-16 Nele Schmidt; Laura Paschen; Karsten Witt
Olfactory dysfunction (OD) is a prominent nonmotor symptom in Parkinson’s disease (PD), and OD is a supportive diagnostic criterion for PD. Physicians often ask their patients if they have noticed a smell disorder. This study evaluates the diagnostic validity of OD self-assessment in PD. To this end, 64 PD patients and 33 age-matched healthy controls were enrolled in a study assessing subjective and
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Follow-Up of Advanced Parkinson’s Disease Patients after Clinical or Surgical Emergencies: A Practical Approach Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-30 Hélio A. G. Teive; Matheus Gomes Ferreira; Carlos Henrique F. Camargo; Renato P. Munhoz
Background. Patients with advanced stage Parkinson’s disease (PD) typically present with a myriad of motor and nonmotor symptoms in addition to comorbidities and, as a consequence, polypharmacy. Objective. To analyze a series of cases of advanced PD in which a clinical or surgical emergency played a trigger role in the irreversible progression of landmarks of the course of the disease. Methods. Data
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Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-29 Pei-Hao Chen; Fang-Yu Cheng; Shih-Jung Cheng; Jin-Siang Shaw
We conducted an observational study to investigate clinical predictors of cognitive decline in patients with mild cognitive impairment (MCI), with a focus on patients with Parkinson’s disease (PD) and Alzheimer’s disease (AD). The study was performed with detailed neuropsychological testing, a portable device for gait analysis, and a comprehensive geriatric assessment for patients with MCI. Cognitive
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Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-17 Daniel Martinez-Ramirez; Edna Sophia Velazquez-Avila; Alejandro Almaraz-Espinoza; Arnulfo Gonzalez-Cantú; Genaro Vazquez-Elizondo; Daniel Overa-Posada; Amin Cervantes-Arriaga; Mayela Rodriguez-Violante; Mirna Gonzalez-Gonzalez
Purpose. Autonomic dysfunction is a common nonmotor feature and early manifestation of Parkinsons disease (PD). Autonomic dysfunction in PD is associated with a worse prognosis. We sought to characterize autonomic dysfunction and identify associated factors in patients with early PD. Methods. An observational, cross-sectional, descriptive, and analytical study was conducted to evaluate patients with
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Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-10 Ting-Chun Fang; Yu-Hsuan Wu; Yi-Huei Chen; Ching-Heng Lin; Ming-Hong Chang
Background. This study aimed to clarify whether Parkinson’s disease (PD) and depression were independent risk factors or with synergic effects in dementia. Methods. Newly diagnosed PD (n = 1213) patients and control subjects (n = 4852) were selected from the Taiwan National Health Insurance Research Database from January 2001 through December 2008. Follow-up ended in 2011 with an outcome of dementia
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Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-10 Na Dong; Zhong Dong; Ying Chen; Xiaosu Gu
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. However, the effect of crocetin on PD remains unclear. In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the
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Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-30 Megan C. Bakeberg; Maddeson Riley; Michelle Byrnes; Alexa Jefferson; Souyma Ghosh; Malcom K. Horne; Sarah McGregor; Rick Stell; Sue Walters; Tess Evans; Katherine Roberts; Frank L. Mastaglia; Ryan S. Anderton
Background. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis
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Influence of the COVID-19 Pandemic on Quality of Life of Patients with Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-10-05 Dengjun Guo; Bing Han; Yuqiang Lu; Chenling Lv; Xiaoling Fang; Zhenzhong Zhang; Zhenguo Liu; Xiaoping Wang
Introduction. This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality of life of patients with Parkinson’s disease (PD). Methods. We conducted a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled
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Parkinson’s Disease-Related Risk of Suicide and Effect of Deep Brain Stimulation: Meta-Analysis Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-27 Juncong Du; Xi Liu; Xuan Zhou; Hui Wang; Wen Zhou; Jin Jiang; Wuxue Peng; Lijuan Mo; Changhong Tan; Lifen Chen
Background. Previous studies investigated the risk of suicide in patients with Parkinson’s disease (PD) but reported discrepant results. Deep brain stimulation (DBS) is an effective therapy for PD, while its effect on suicide risk has seldom been researched. This meta-analysis aimed to estimate the risk of suicide and/or suicidal ideation in PD patients and in PD patients who underwent DBS. Methods
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Detection of Phosphorylated Alpha-Synuclein in the Muscularis Propria of the Gastrointestinal Tract Is a Sensitive Predictor for Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-23 Goichi Beck; Yumiko Hori; Yoshito Hayashi; Eiichi Morii; Tetsuo Takehara; Hideki Mochizuki
Background. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. Lewy bodies and neurites, the pathological hallmarks of PD, are found in the enteric nervous system (ENS) as well as the central nervous system. Constipation is a well-documented premotor symptom in PD, and recent reports have demonstrated Lewy pathology in gastrointestinal
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Evaluation of Wearable Sensor Devices in Parkinson’s Disease: A Review of Current Status and Future Prospects Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-23 Ruirui Lu; Yan Xu; Xiaohui Li; Yongli Fan; Weiqi Zeng; Yang Tan; Kang Ren; Wenwu Chen; Xuebing Cao
Parkinson’s disease (PD) decreases the quality of life of the affected individuals. The incidence of PD is expected to increase given the growing aging population. Motor symptoms associated with PD render the patients unable to self-care and function properly. Given that several drugs have been developed to control motor symptoms, highly sensitive scales for clinical evaluation of drug efficacy are
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Clinical Features and Correlates of Poor Nighttime Sleepiness in Patients with Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-14 Xiaoling Qin; Xue Li; Gang Chen; Xu Chen; Mingyu Shi; Xue-kui Liu; Zai-li Li; Zai-e Xin; Dianshuai Gao
Objective. The present study investigated the clinical features and correlates of poor nighttime sleepiness (PNS) in patients with Parkinson’s disease (PD). Methods. One hundred ten patients with PD (divided into PD-PNS group and PD-nPNS group) and forty-seven controls (nPD-PNS group) were enrolled in this study. Demographic information was collected. Patients were assessed according to the unified
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Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-14 Sheng Zhuang; Fu-Yu Wang; Xin Gu; Jia-Jing Wu; Cheng-Jie Mao; Hao Gui; Jing Chen; Chun-Feng Liu
Background. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmotor symptoms of individuals with PD. Methods. We conducted a randomized, single-blind, sham-controlled
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Effects of Vestibular Rehabilitation on Fatigue and Activities of Daily Living in People with Parkinson's Disease: A Pilot Randomized Controlled Trial Study. Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-10 Amirabas Abasi,Parvin Raji,Joseph H Friedman,Mohammad-Reza Hadian,Reza Hoseinabadi,Somaye Abbasi,Ahmadreza Baghestani
One of the most disabling nonmotor symptoms in persons with Parkinson’s disease is fatigue, which can decrease the quality of life by restricting the function and activities of daily living (ADL). Nonetheless, sufficient evidence for treating fatigue, including drug or nondrug treatment, is not available. In this study, we evaluated the probable effects of vestibular rehabilitation on fatigue and ADL
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Exercise Therapies for Parkinson's Disease: A Systematic Review and Meta-Analysis. Parkinson's Dis. (IF 1.758) Pub Date : 2020-09-08 Hyun-Young Choi,Ki-Ho Cho,Chul Jin,JiEun Lee,Tae-Hun Kim,Woo-Sang Jung,Sang-Kwan Moon,Chang-Nam Ko,Seung-Yeon Cho,Chan-Yong Jeon,Tae Young Choi,Myeong Soo Lee,Sang-Ho Lee,Eun Kyoung Chung,Seungwon Kwon
Recently, rehabilitative exercise therapies have been described as an important method of overcoming the limitations of the conventional therapies for Parkinson’s disease. The present study aimed to evaluate efficacy and safety of exercise therapies for Parkinson’s disease. Randomized controlled trials that evaluated exercise therapies in patients with Parkinson’s disease until December 2016 were searched
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Validity and Reliability of Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2) in Iranian People with Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-08-18 Maryam Mehdizadeh,Seyed-Mohammad Fereshtehnejad,Sepide Goudarzi,Ainaz Moshtagh,Farzaneh Dehghanian Nasrabadi,Sayed Amir Hasan Habibi,Ghorban Taghizadeh
Purpose. Pain is one of the nonmotor symptoms of Parkinson’s disease (PD) that, in order to be better managed, requires to be evaluated. Evaluations are done using pain assessment scales such as the Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2). The goal of this study was to assess the psychometric properties of SF-MPQ-2 to measure pain in people with PD. Methods. Four hundred and twenty-eight
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A Study for Expanding Application Sites for Rotigotine Transdermal Patch. Parkinson's Dis. (IF 1.758) Pub Date : 2020-08-10 Hitoshi Kujirai,Sakiko Itaya,Yumi Ono,Makoto Takahashi,Akira Inaba,Yasushi Shimo,Nobutaka Hattori,Satoshi Orimo
The rotigotine transdermal patch (RTP) is a dopamine agonist used to treat Parkinson’s disease (PD). Some PD patients cannot continue RTP treatment due to application site reactions. We explored sites for RTP where application site reactions are less severe than those in the six approved application sites. Thirty PD patients (12 men, mean age = 76 years) who underwent RTP at the approved sites and
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Prediction of Life Satisfaction in People with Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-29 Stina B Jonasson,Merja Rantakokko,Erika Franzén,Susanne Iwarsson,Maria H Nilsson
Introduction. People with Parkinson’s disease (PD) have lower life satisfaction (LS) than healthy peers. No study has yet identified predictors of LS in people with PD. Such information would be valuable for health care and future interventions that aim to maintain or increase LS. Aim. To examine how LS evolved in people with PD over a 3-year period, as well as to identify predictive factors of LS
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Analysis of Motor Complication and Relative Factors in a Cohort of Chinese Patients with Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-29 Baihua Sun,Tao Wang,Nianying Li,Jin Qiao
Objective. Motor complications are common in Parkinson’s disease (PD). The reported occurrence of motor complications varies across regions and races. The aim of our study was to describe the development of dyskinesias and motor fluctuations among Chinese PD patients and the relative risk factors. Methods. In the current cross-sectional survey study, PD patients with motor fluctuations and dyskinesia
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"Does the Response to Morning Medication Predict the ADL-Level of the Day in Parkinson's Disease?" Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-27 Trine Hørmann Thomsen,Troels Wesenberg Kjær,Lene Bastrup Jørgensen,Anita Haahr,Kristian Winge
Background. Individuals with Parkinson’s Disease (PD) have bradykinesia during mobility tasks in the morning before intake of dopaminergic treatment and have difficulties managing Activities of Daily Living (ADLs). Early morning off (EMO) refers to off-states in the morning where the severity of bradykinesia is increased and causes a decrease in mobility related to wearing off of effects of medication
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Skin Temperature in Parkinson's Disease Measured by Infrared Thermography. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-25 Mathias Møller Purup,Karoline Knudsen,Pall Karlsson,Astrid Juhl Terkelsen,Per Borghammer
Background. Patients with Parkinson’s disease (PD) often show peripheral autonomic dysfunction and depositions of pathological alpha-synuclein aggregates in the skin. However, functional consequences of this skin involvement have received little attention. Objective. To determine thermographic differences in the skin between healthy controls (HCs) and PD patients on hands, feet, and trunk and to correlate
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Saturdays-in-Motion: Education and Empowerment through an Interdisciplinary Team Approach for Parkinson's Disease in Cali-Colombia. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-15 Beatriz E Muñoz,Valentina Quintana-Peña,Maria C Gonzalez,Jaime A Valderrama,Yor Jaggy Castaño-Pino,Domiciano Rincón,Andrés Navarro,Jorge L Orozco
Introduction. Parkinson’s disease (PD) is one of the most prevalent age-related neurodegenerative disorders. The progression of PD produces an important disease burden in patients due to functional impairment, which also has repercussions on caregivers. In addition, it has become a challenge for health systems, especially in developing countries, which have limited resources. Multidisciplinary teams
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Association of Tooth Loss with New-Onset Parkinson's Disease: A Nationwide Population-Based Cohort Study. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-13 Ho Geol Woo,Yoonkyung Chang,Ji Sung Lee,Tae-Jin Song
Introduction. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson’s disease
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Effect of Exercise on Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-09 Kui Chen,Yan Tan,You Lu,Jiayan Wu,Xueyuan Liu,Yanxin Zhao
Background. Exercise has an integral impact on the physical and mental wellbeing of patients with Parkinson’s disease (PD), yet no comprehensive and quantitative analysis has been conducted on the effect of exercise on quality of life (QoL) in these patients. This study aimed to evaluate the effect of exercise on overall QoL and different domains of QoL in people with PD, as well as investigating the
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Self-Reported Nonadherence Predicts Changes of Medication after Discharge from Hospital in People with Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-07-04 Francis Feldmann,Hannah M Zipprich,Otto W Witte,Tino Prell
Background. Medication is often changed after hospital discharge in people with Parkinson’s disease (PD). Objective. This observational study aimed to describe changes in PD medication after discharge and explore their association with self-reported adherence and clinical parameters. Methods. During hospitalisation sociodemographic characteristics, the Movement Disorder Society-sponsored revision of
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The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson's Disease: A Resting-State fMRI Study. Parkinson's Dis. (IF 1.758) Pub Date : 2020-06-27 Kai Li,Hong Zhao,Chun-Mei Li,Xin-Xin Ma,Min Chen,Shu-Hua Li,Rui Wang,Bao-Hui Lou,Hai-Bo Chen,Wen Su
Objective. Motor symptoms are usually asymmetric in Parkinson’s disease (PD), and asymmetry in PD may involve widespread brain areas. We sought to evaluate the effect of asymmetry on the whole brain spontaneous activity using the measure regional homogeneity (ReHo) through resting-state functional MRI. Methods. We recruited 30 PD patients with left onset (LPD), 27 with right side (RPD), and 32 controls
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Sacral Reflex Characteristics of Patients with Multiple System Atrophy. Parkinson's Dis. (IF 1.758) Pub Date : 2020-06-27 Zhifang Pan,Xueming Zhang,Xun Wang,Binbin Deng,Wanli Zhang,Huanjie Huang
Objectives. To observe and analyze the parameters of the sacral reflex and pudendal nerve somatosensory evoked potential (SSEP) in patients with multiple system atrophy (MSA) with respect to factors such as age, disease course, and subtype and provide evidence for the clinical diagnosis of MSA. Materials and Methods. A total of 51 MSA patients and 30 healthy controls were selected from the First Affiliated
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Motor/Nonmotor Symptoms and Progression in Patients with Parkinson's Disease: Prevalence and Risks in a Longitudinal Study. Parkinson's Dis. (IF 1.758) Pub Date : 2020-06-20 Asako Yoritaka,Yasushi Shimo,Taku Hatano,Nobutaka Hattori
We previously assessed the prevalence and risks of motor/nonmotor symptoms in a large sample of Japanese patients with Parkinson’s disease. In the present study, we longitudinally assessed the prevalence and risk of motor/nonmotor symptoms, changes in treatment, disease progression, and death in patients with Parkinson’s disease. We enrolled 1,227 patients diagnosed and treated at our hospital in Tokyo
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Validation of Parkinson's Disease-Related Questionnaires in South Africa. Parkinson's Dis. (IF 1.758) Pub Date : 2020-06-13 Gill Nelson,Ntombizodwa Ndlovu,Nicola Christofides,Tintswalo M Hlungwani,Irene Faust,Brad A Racette
Background. There are very few epidemiological studies investigating Parkinson’s disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use. Objective. The objective of the study was to validate two commonly used PD questionnaires in an African population. Methods. The PD Screening Questionnaire (PDSQ) and Parkinson’s
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Role of Long Noncoding RNAs in Parkinson's Disease: Putative Biomarkers and Therapeutic Targets. Parkinson's Dis. (IF 1.758) Pub Date : 2020-06-12 Qiankun Lv,Ziyu Wang,Zhen Zhong,Wei Huang
Parkinson’s disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigidity, and tremor. Age is the main risk factor. Long noncoding RNAs (lncRNAs) are novel RNA molecules of more than 200 nucleotides in length. They may be involved in the regulation of many pathological processes of PD. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial
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Evidence of Rehabilitative Impact of Progressive Resistance Training (PRT) Programs in Parkinson Disease: An Umbrella Review. Parkinson's Dis. (IF 1.758) Pub Date : 2020-05-26 T Paolucci,S Sbardella,C La Russa,F Agostini,M Mangone,L Tramontana,A Bernetti,M Paoloni,L Pezzi,R G Bellomo,V Santilli,R Saggini
Parkinson disease (PD) is a chronic neurodegenerative condition that leads to progressive disability. PD-related reductions in muscle strength have been reported to be associated with lower functional performance and balance confidence with an increased risk of falls. Progressive resistance training (PRT) improves strength, balance, and functional abilities. This umbrella review examines the efficacy
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Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson's Patients. Parkinson's Dis. (IF 1.758) Pub Date : 2020-05-22 Maria L Bringas Vega,Shengnan Liu,Min Zhang,Ivonne Pedroso Ibañez,Lilia M Morales Chacon,Lidice Galan Garcia,Vanessa Perez Bocourt,Marjan Jahanshahi,Pedro A Valdes-Sosa
We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson’s Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication
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Intestinal Levodopa/Carbidopa Infusion as a Therapeutic Option for Unresponsive Freezing of Gait after Deep Brain Stimulation in Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-05-14 Belén González-Herrero,Serge Jauma-Classen,Roser Gómez-Llopico,Gerard Plans,Matilde Calopa
Background. Treatment of freezing of gait (FOG) is always challenging because of its unpredictable nature and multifactorial physiopathology. Intestinal levodopa infusion has been proposed in recent years as a valuable option for its improvement. FOG in Parkinson’s disease (PD) can appear after deep brain stimulation in patients who never had gait symptoms. Objective. To study the effects of intestinal
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Direct Cost of Parkinson's Disease: A Real-World Data Study of Second-Line Therapies. Parkinson's Dis. (IF 1.758) Pub Date : 2020-05-12 Elisa Gomez-Inhiesto,María Teresa Acaiturri-Ayesta,Iker Ustarroz-Aguirre,Diana Camahuali,Maider Urtaran-Laresgoiti,Marisol Basabe-Aldecoa,Roberto Nuño-Solinís,Elena Urizar
Parkinson’s disease is one of the main reasons for neurological consultation in Spain. Due to the nature of the disease, it impacts patients, families, and caregivers. Parkinson’s disease is a degenerative disease with no cure, although second-line therapies have recently improved the quality of life of patients in advanced stages. The aim of this study was to analyse the costs of the following therapies:
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Self-Management Education for Persons with Parkinson's Disease and Their Care Partners: A Quasi-Experimental Case-Control Study in Clinical Practice. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-30 Carina Hellqvist,Carina Berterö,Nil Dizdar,Märta Sund-Levander,Peter Hagell
Background. Parkinson’s disease is a neurodegenerative condition with both physical and mental consequences that affect many aspects of everyday life. Persons with Parkinson’s disease and their care partners want guidance from healthcare services in order to develop skills to adjust to life with a long-term condition. The Swedish National Parkinson School is a dyadic self-management programme to support
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Psychosocial Adjustment of In-Home Caregivers of Family Members with Dementia and Parkinson's Disease: A Comparative Study. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-28 María Cristina Lopes Dos Santos,María Victoria Navarta-Sánchez,José Antonio Moler,Ignacio García-Lautre,Sagrario Anaut-Bravo,Mari Carmen Portillo
Neurodegenerative diseases such as Parkinson’s and dementia are highly prevalent worldwide. People who suffer from these disorders often receive in-home care and assistance from family members, who must dedicate a considerable amount of time to the care recipient. The study of family caregivers’ psychosocial adjustment to the degenerative processes of both conditions is of interest due to the implications
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Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-25 Han-Lin Chiang,Chiung Mei Chen,Yi-Chun Chen,Chih-Ying Chao,Yih-Ru Wu,Guey-Jen Lee-Chen
Parkinson’s disease (PD) is a neurodegenerative disorder related to nigrostriatal dopaminergic neuron degeneration and iron accumulation. As a cellular oxygen sensor, prolyl hydroxylase domain containing protein 2 (PHD2, encoded by egl-9 family hypoxia inducible factor 1, EGLN1) modifies hypoxia-inducible factor alpha (HIF-α) protein for proteasomal destruction under normoxic condition. In addition
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Nonmotor-Related Quality of Life in Parkinson's Patients with Subjective Memory Complaints: Comparison with PDQ-39. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-20 Alexis Lionel Jenny,Antonia Meyer,Ivana Handabaka,Pasquale Calabrese,Peter Fuhr,Ute Gschwandtner
Background. Parkinson’s disease (PD) is associated with cognitive decline, progressing from subjective memory complaints (SMC) via mild cognitive impairment (MCI) to dementia. SMC are only measurable by an interview and thus rely on individuals reporting a subjectively perceived worsening of cognitive functioning. Cognitive decline is accompanied by a reduction in quality of life (QoL); however, the
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Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson's Disease before and after Acute Levodopa Challenge. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-09 Zhuang Wu,Xu Jiang,Min Zhong,Bo Shen,Jun Zhu,Yang Pan,Jingde Dong,Pingyi Xu,Wenbin Zhang,Li Zhang
Background. Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson’s disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective. The purpose of this study was to decompose the complex ankle joint movement, measure ankle joint changes before and after the acute
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Taking Time: A Mixed Methods Study of Parkinson's Disease Caregiver Participation in Activities in Relation to Their Wellbeing. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-09 Lia Prado,Rebecca Hadley,Dawn Rose
Objectives. Although many studies have shown that psychosocial interventions, such as dance classes, can improve quality of life for people with Parkinson’s disease (PD): few have addressed the role of, and potential benefits to, the caregivers in such activities. This mixed methods study explored the reasons for caregiver participation in a variety of activities and considered whether participation
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The Beneficial Effects of Conventional Visual Cues Are Retained When Augmented Reality Glasses Are Worn. Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-07 Sabine Janssen,Jaap de Ruyter van Steveninck,Hizirwan S Salim,Bastiaan R Bloem,Tjitske Heida,Richard J A van Wezel
Wearing smart glasses may be distracting and thus annihilate the beneficial effects of cues on freezing of gait in Parkinson’s disease. Furthermore, augmented reality cues might be effective in reducing FOG specifically in cueing-responsive patients. We present a single-patient study in which a patient with Parkinson’s disease traversed a doorway under different cueing conditions. Wearing augmented
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Combining a Cognitive Concurrent Task with a Motor or Motor-Cognitive Task: Which Is Better to Differentiate Levels of Affectation in Parkinson's Disease? Parkinson's Dis. (IF 1.758) Pub Date : 2020-04-04 Arturo X Pereiro,Bea Resúa,David Facal,José María Cancela-Carral
Introduction. Cognitive decline usually coexists with motor impairment in PD. Multitask settings provide appropriate measures to evaluate the complex interaction between motor and cognitive impairments. The main objective was to analyze which concurrent task, i. e., motor or hybrid motor-cognitive, in combination with a cognitive task better differentiates between PD patients with mild and moderate
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Event-Related Potentials Elicited by Face and Face Pareidolia in Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-03-31 Gulsum Akdeniz,Gonul Vural,Sadiye Gumusyayla,Hesna Bektas,Orhan Deniz
Background. Parkinson’s disease is associated with impaired ability to recognize emotional facial expressions. In addition to a visual processing disorder, a visual recognition disorder may be involved in these patients. Pareidolia is a type of complex visual illusion that permits the interpretation of a vague stimulus as something known to the observer. Parkinson’s patients experience pareidolic illusions
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Patients' Perspective of Comprehensive Parkinson Care in Rural Victoria. Parkinson's Dis. (IF 1.758) Pub Date : 2020-03-31 Robert Iansek,Mary Danoudis
Introduction. There is a higher prevalence of Parkinson’s disease (PD) in rural Australia and a poorer perceived quality of life of rural Australians with PD. Coordinated multidisciplinary teams specialised and experienced in the treatment of PD are recommended as the preferred model of care best able to manage the complexities of this disorder. There remains a lack of team-based specialised PD services
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Ultrasonography of the Vagus Nerve in the Diagnosis of Parkinson's Disease. Parkinson's Dis. (IF 1.758) Pub Date : 2020-03-31 Ovidijus Laucius,Renata Balnytė,Kęstutis Petrikonis,Vaidas Matijošaitis,Neringa Jucevičiūtė,Tadas Vanagas,Vytautas Danielius
Background. It is currently impossible to diagnose Parkinson’s disease (PD) in the premotor phase even though at the time of motor symptom onset the number of already degenerated dopaminergic substantia nigra neurons is considerable. Degeneration of the dorsal nucleus of the vagus nerve (VN) has been reported early in the disease course, and it could lead to impaired function of the VN, resulting in
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Proactive and Integrated Management and Empowerment in Parkinson's Disease: Designing a New Model of Care. Parkinson's Dis. (IF 1.758) Pub Date : 2020-03-30 Emma Tenison,Agnes Smink,Sabi Redwood,Sirwan Darweesh,Hazel Cottle,Angelika van Halteren,Pieter van den Haak,Ruth Hamlin,Jan Ypinga,Bastiaan R Bloem,Yoav Ben-Shlomo,Marten Munneke,Emily Henderson
Parkinson’s disease is the second most common neurodegenerative condition after Alzheimer’s disease. The number of patients will rise dramatically due to ageing of the population and possibly also due to environmental issues. It is widely recognised that the current models of care for people with Parkinson’s disease or a form of atypical parkinsonism lack continuity, are reactive to problems rather
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Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson's Disease Patients over a Decade in Singapore. Parkinson's Dis. (IF 1.758) Pub Date : 2020-03-30 Shermyn Neo,Sheng Yong Aidan Wong,Hwee Lan Ng,Wei Li,Kay Yaw Tay,Wing Lok Au,Louis Chew Seng Tan
Objective. The aim of this study is to compare Parkinson’s disease (PD) treatment practices by movement disorder (MD) specialists across a decade, and to determine the factors that influence drug choice for the motor symptoms of PD in newly diagnosed drug-naïve patients. Methods. This prospective temporal analysis included patients seen at the National Neuroscience Institute in Singapore and diagnosed