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Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkisnsonism Parkinson's Dis. (IF 3.2) Pub Date : 2024-3-5 Alon Sinai, Maria Nassar, Lev Shornikov, Marius Constantinescu, Menashe Zaaroor, Ilana Schlesinger
Background. Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson’s disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. Objective. To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple
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Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2024-2-21 Alina Benítez-Castañeda, Verónica Anaya-Martínez, Armando de Jesús Espadas-Alvarez, Ana Luisa Gutierrez-Váldez, Luis Fernando Razgado-Hernández, Patricia Emmanuelle Reyna-Velazquez, Liz Quintero-Macias, Daniel Martínez-Fong, Benjamín Florán-Garduño, Jorge Aceves
In Parkinson’s disease (PD), progressive degeneration of nigrostriatal innervation leads to atrophy and loss of dendritic spines of striatal medium spiny neurons (MSNs). The loss disrupts corticostriatal transmission, impairs motor behavior, and produces nonmotor symptoms. Nigral neurons express brain-derived neurotropic factor (BDNF) and dopamine D3 receptors, both protecting the dopamine neurons
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Improvement by Medication Less than Expected in Parkinson’s Disease: Blinded Evaluation of Levodopa Response Parkinson's Dis. (IF 3.2) Pub Date : 2024-2-21 Mette Niemann Johansen, Anna Handberg, Mohamed El Haddouchi, Josefine Grundtvig, Steen Rusborg Jensen, Lisette Salvesen, Annemette Løkkegaard
Background. The latest Movement Disorder Society (MDS) diagnostic criteria require a good and sustained response to medication to get a diagnosis of Parkinson’s disease, PD. Objective. The aim of this study was to evaluate levodopa response in a group of patients with probable PD, diagnosed by movement disorder specialists. Methods. An acute levodopa challenge test (LDCT) was performed after pausing
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Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson’s Disease Patients after Deep Brain Stimulation: A Cohort Study Parkinson's Dis. (IF 3.2) Pub Date : 2024-2-7 Ying Gao, Jue Wang, Linbin Wang, Dianyou Li, Bomin Sun, Xian Qiu
Objectives. The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. Methods. Ninety-three patients diagnosed with Parkinson’s disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included
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A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2024-1-16 Pauli Seppänen, Markus M. Forsberg, Miia Tiihonen, Heikki Laitinen, Selena Beal, David C. Dorman
Background. Rasagiline or pramipexole monotherapy has been suggested for the management of early Parkinson’s disease (PD). The aim of this research was to systematically review the clinical efficacy and safety of rasagiline or pramipexole in early PD (defined as disease duration ≤5 years and Hoehn and Yahr stage of ≤3). Methods. Randomized controlled trials (RCTs) of rasagiline or pramipexole for early
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Alprazolam Reduces Freezing of Gait (FOG) and Improves FOG-Related Gait Deficiencies Parkinson's Dis. (IF 3.2) Pub Date : 2024-1-9 Abdullah Al Jaja, Téa Sue, Margaret Prenger, Ken N. Seergobin, Jessica A. Grahn, Penny A. MacDonald
Background. Freezing of gait (FOG) is an intractable motor symptom in Parkinson’s disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety itself provokes FOG. We investigated the effect of acute anxiety reduction via alprazolam on FOG in PD. Methods. In ten patients with PD, FOG, and normal cognition
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Single-Cell Analyses Reveal Necroptosis’s Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson’s Disease Progression Parkinson's Dis. (IF 3.2) Pub Date : 2023-12-19 Xiaomei Zeng, Zhifen Han, Kehan Chen, Peng Zeng, Yidan Tang, Lijuan Li
Parkinson’s disease (PD) is a common neuron degenerative disease among the old, characterized by uncontrollable movements and an impaired posture. Although widely investigated on its pathology and treatment, the disease remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) has been applied to the area of PD, providing valuable data for related research. However, few works have taken
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Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-12-9 Caroline Ran, Karin Wirdefeldt, Olof Sydow, Per Svenningsson, Rochellys Diaz Heijtz
Introduction. Parkinson’s disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD. Methods
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The Role of Muscle Strength in the Sit-to-Stand Task in Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-10-23 José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Robert Fekete
Background. Rising from a chair or the sit-to-stand (STS) task is frequently impaired in individuals with Parkinson’s disease (PD). These patients commonly attribute such difficulties to weakness in the lower extremities. However, the role of muscle strength in the STS transfer task has not been fully elucidated. Objective. We aim at determining the role of muscle strength in the STS task. Methods
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Protective Role of AMPK against PINK1B9 Flies’ Neurodegeneration with Improved Mitochondrial Function Parkinson's Dis. (IF 3.2) Pub Date : 2023-10-12 Guoliang Xiang, Xueyi Wen, Wenjing Wang, Tianchan Peng, Jiazhen Wang, Qinghua Li, Junfang Teng, Ying Cui
Adenosine 5′-monophosphate-activated protein kinase (AMPK)’s effect in PTEN-induced kinase 1 (PINK1) mutant Parkinson’s disease (PD) transgenic flies and the related mechanism is seldom studied. The classic MHC-Gal4/UAS PD transgenic flies was utilized to generate the disease characteristics specifically expressed in flies’ muscles, and Western blot (WB) was used to measure the expression of the activated
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The Neuroprotective Effect of Isotetrandrine on Parkinson’s Disease via Anti-Inflammation and Antiapoptosis In Vitro and In Vivo Parkinson's Dis. (IF 3.2) Pub Date : 2023-10-10 Ching-Hu Wu, Kun-Ling Lin, Cheng-Yu Long, Chien-Wei Feng
Parkinson’s disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro, cells were cotreated with ITD and LPS to detect the inflammatory-related protein
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Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-10-10 Kristina Rosqvist, Per Odin
Background. National as well as international Parkinson’s disease (PD) treatment guidelines are available to guide clinicians. Previous research has shown that nonmotor symptoms (NMS) are pronounced in late-stage PD and has suggested that current treatment is insufficient and could be improved. Objectives. The aim of this study was to investigate to which degree the national and international treatment
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Levodopa Prescription Patterns in Patients with Advanced Parkinson’s Disease: A Japanese Database Analysis Parkinson's Dis. (IF 3.2) Pub Date : 2023-9-27 Atsushi Takeda, Toru Baba, Jun Watanabe, Masahiko Nakayama, Hiroyuki Hozawa, Miwako Ishido
Prescription doses of levodopa in patients with advanced Parkinson’s disease (PD) are generally lower in Japan than in the United States or Europe, although Japanese guidelines for the management of PD recommend increasing the dosage as the disease progresses. However, data regarding levodopa prescription practices in patients with advanced PD in the clinical setting are limited. This retrospective
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A Dual GLP-1/GIP Receptor Agonist Is More Effective than Liraglutide in the A53T Mouse Model of Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-9-25 Zijuan Zhang, Ming Shi, Zhengmin Li, Yuan Ling, Luke Zhai, Ye Yuan, He Ma, Li Hao, Zhonghua Li, Zhenqiang Zhang, Christian Hölscher
Parkinson’s disease (PD) is a complex syndrome with many elements, such as chronic inflammation, oxidative stress, mitochondrial dysfunction, loss of dopaminergic neurons, build-up of alpha-synuclein (α-syn) in cells, and energy depletion in neurons, that drive the disease. We and others have shown that treatment with mimetics of the growth factor glucagon-like peptide 1 (GLP-1) can normalize energy
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Mercury and Parkinson’s Disease: Promising Leads, but Research Is Needed Parkinson's Dis. (IF 3.2) Pub Date : 2023-9-16 E. Fuller Torrey, Wendy Simmons
Environmental toxicants are thought to play a major role in the pathogenesis of Parkinson’s disease. In reviewing the literature on heavy metals known to be toxicants, we noted several recent studies on mercury suggesting a possible role in the etiology of some cases of this disease. We therefore undertook a review of this association, focusing especially on peer-reviewed articles to avoid the bias
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Qualitative Analysis of Attitudes, Knowledge, and Interest in Research of People with Parkinson’s Disease and Their Care Partners Receiving Accessible Research Education Parkinson's Dis. (IF 3.2) Pub Date : 2023-9-11 Maria E. Ramos, Suraj Pothineni, Liang Ni, Allison A. Bay, Todd Prusin, Madeleine E. Hackney
Background. People with Parkinson’s disease (PWP) and their care partners (CP) are underrepresented in research. Methods. As an eight-week research advocacy training program, TeleDREAMS was designed to increase understanding of, and participation in, clinical research by older adults through topics on the research process. Qualitative analysis was conducted to explore themes from 365 thirty-minute
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Supplementary Motor Area Activity Differs in Parkinson’s Disease with and without Freezing of Gait Parkinson's Dis. (IF 3.2) Pub Date : 2023-9-4 J. Sebastian Marquez, Ronny P. Bartsch, Moritz Günther, S. M. Shafiul Hasan, Or Koren, Meir Plotnik, Ou Bai
The study aimed to investigate the neural changes that differentiate Parkinson’s disease patients with freezing of gait and age-matched controls, using ambulatory electroencephalography event-related features. Compared to controls, definite freezers exhibited significantly less alpha desynchronization at the motor cortex about 300 ms before and after the start of overground walking and decreased low-beta
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Delivering Optimal Care to People with Cognitive Impairment in Parkinson’s Disease: A Qualitative Study of Patient, Caregiver, and Professional Perspectives Parkinson's Dis. (IF 3.2) Pub Date : 2023-8-29 Jennifer S. Pigott, Nathan Davies, Elizabeth Chesterman, Joy Read, Danielle Nimmons, Kate Walters, Megan Armstrong, Anette Schrag
Background. Cognitive impairment is common in Parkinson’s disease (PD) and associated with lower quality of life. Cognitive impairment in PD manifests differently to other dementia pathologies. Provision of optimal care requires knowledge about the support needs of this population. Methods. Eleven people with PD and cognitive impairment (PwP), 10 family caregivers, and 27 healthcare professionals were
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Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features Parkinson's Dis. (IF 3.2) Pub Date : 2023-8-23 Arash Yaghoobi, Homa Seyedmirzaei, Moein Ala
Introduction. Despite remarkable progress in identifying Parkinson’s disease (PD) genetic risk loci, the genetic basis of PD remains largely unknown. With the help of the endophenotype approach and using data from dopamine transporter single-photon emission computerized tomography (DaTscan), we identified potentially involved genes in PD. Method. We conducted an imaging genetic study by performing
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Dyrk1a Phosphorylation of α-Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-7-10 Yuxuan Yong, Qinfen Wu, Xinling Meng, Ranran Lu, Huan Xia, Feifei Pei, Xinling Yang
Objective. To investigate the role of aberrant Dyrk1a expression in phosphorylation modification at the α-synuclein serine 129 (Ser129) site to analyze its molecular mechanism in mediating apoptosis of PD. Methods. The protein level of P-α-synuclein (Ser129), α-synuclein, Bcl-2, Bax, active caspase 3, GSK3β, PI3K, AKT, and cyclinD1 were detected. The mRNA transcript levels of Dyrk1a and DAT and protein
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Quantitative Analysis of Postural Balance in Faller and Nonfaller Patients with Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-6-20 Do Young Kwon, Yuri Kwon, Ji-An Choi, Junghyuk Ko, Ji-Won Kim
Background. Postural instability has been identified as a fall risk factor with a significant impact on the quality of life of patients with Parkinson’s disease (PD). The aim of this study was to compare the center of pressure (COP) between faller and nonfaller patients with PD during static standing. Methods. Thirty-two faller patients and 32 nonfaller patients with PD participated in this study.
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Validation of the Non-Motor Symptoms Scale for Parkinson’s Disease of Persian Version Parkinson's Dis. (IF 3.2) Pub Date : 2023-6-9 Zahra Eghlidos, Aida Abolhassanbeigi, Zahra Rahimian, Samaneh Khazraei, Vahid Reza Ostovan
Objective. We aimed to assess the validity and reliability of the Persian version of the NonMotor Symptoms Scale (NMSS) in Iranian patients with PD. Methods. This cross-sectional study was conducted in patients with PD. After the cross-cultural adaptation of the NMSS, the acceptability, reliability, precision, and validity of the Persian NMSS were evaluated. For this purpose, in addition to NMSS, we
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The Rehabilitative Effect of Archery Exercise Intervention in Patients with Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-6-8 Chiu-Ying Chen, Wei-Ning Wang, Ming-Kuei Lu, Yu-Wan Yang, Tsung Yu, Trong-Neng Wu, Chon-Haw Tsai
Background. Archery exercise exerts a rehabilitative effect on patients with paraplegia and might potentially serve as complementary physiotherapy for patients with Parkinson’s disease. Objective. This study aimed to examine the rehabilitative effects of an archery intervention. Methods. A randomized controlled trial of a 12-week intervention was performed in patients with idiopathic Parkinson’s disease
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Efficacy and Feasibility of Remote Cognitive Remediation Therapy in Parkinson’s Disease: A Randomized Controlled Trial Parkinson's Dis. (IF 3.2) Pub Date : 2023-6-1 Lisa Hoffman, Nicholas D. Burt, Nicholas R. Piniella, Madison Baker, Nicole Volino, Saeed Yasin, Min-Kyung Jung, Adena Leder, Amber Sousa
Background. Non-motor symptoms of Parkinson’s disease (PD) such as cognitive impairment are common and decrease patient quality of life and daily functioning. While no pharmacological treatments have effectively alleviated these symptoms to date, non-pharmacological approaches such as cognitive remediation therapy (CRT) and physical exercise have both been shown to improve cognitive function and quality
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Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang Parkinson's Dis. (IF 3.2) Pub Date : 2023-6-1 Rurui Wei, Yan Zhang, Peishan Li, Zeheng Xu, La Zhang, Yan He, Qinfen Wu, Youcai Shi, Yang Yuan, Abudula Aisha
Background. Transcranial sonography (TCS) is a noninvasive test that can reveal structural changes in the substantia nigra (SN) in Parkinson’s disease (PD). The purpose of this study was to investigate the relationship between SN signatures and clinical features in PD patients in a multiethnic region of China. Methods. A total of 147 patients with PD were included in the study, and all of whom had
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Vulnerability of Parkinson’s Patients to COVID-19 and Its Consequences and Effects on Them: A Systematic Review Parkinson's Dis. (IF 3.2) Pub Date : 2023-4-24 Sorayya Rezayi, Meysam Rahmani Katigari, Leila Shahmoradi, Mehrbakhsh Nilashi
Introduction. Parkinson’s disease (PD) is the second most common neurological disorder. Patients with PD were affected by the COVID-19 pandemic in many different ways. This study’s principal purpose is to assess PD patients' vulnerability to COVID-19 and its consequences. Method. This systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA)
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Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson’s Disease via Bioinformatics Analysis Parkinson's Dis. (IF 3.2) Pub Date : 2023-4-14 Yunan Zhou, Zhihui Li, Chunling Chi, Chunmei Li, Meimei Yang, Bin Liu
Parkinson’s disease (PD) is the second most common neurodegenerative disease, with significant socioeconomic burdens. One of the crucial pathological features of PD is the loss of dopaminergic neurons in the substantia nigra (SN). However, the exact pathogenesis remains unknown. Moreover, therapies to prevent neurodegenerative progress are still being explored. We performed bioinformatics analysis
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Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group Parkinson's Dis. (IF 3.2) Pub Date : 2023-4-6 Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Silvia Jesús, Maria Teresa Buongiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira
Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November
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Exploring the Caregiver Role after Deep Brain Stimulation Surgery for Parkinson’s Disease: A Qualitative Analysis Parkinson's Dis. (IF 3.2) Pub Date : 2023-4-5 Suzette Shahmoon, Patricia Limousin, Marjan Jahanshahi
This pilot study aimed to explore how caregiver spouses make sense of themselves one and five years after their partner’s deep brain stimulation (DBS) surgery for Parkinson’s disease. 16 spouse (8 husbands and 8 wives) caregivers were recruited for the interview. Eight struggled to reflect on their own lived experience and primarily focused on the impact of PD on their partners, such that their transcripts
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Association between Cognitive Impairment and Hippocampal Subfield Volumes in Multiple System Atrophy Parkinson's Dis. (IF 3.2) Pub Date : 2023-3-6 Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Jiaqi Wang, Shoichi Ito, Satoshi Kuwabara
This study aimed to explore morphological changes of hippocampal subfields in patients with multiple system atrophy (MSA) with and without cognitive impairment using FreeSurfer-automated segmentation of hippocampal subfield techniques and their relationship with cognitive function. We enrolled 75 patients with MSA classified as cognitively impaired MSA (MSA-CI, n = 40) and cognitively preserved MSA
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The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients Parkinson's Dis. (IF 3.2) Pub Date : 2023-2-23 Zeynep Tuncer, Gamze Dereli Can, Hava Dönmez Keklikoğlu, Fatma Ayşen Eren, Fatma Yülek, Orhan Deniz
Background. In Parkinson’s disease (PD), dopamine deficiency is present not only in the nigrostriatal pathway but also in the retinal and visual pathways. Optic coherence tomography (OCT) can be used as morphological evidence of visual influence from early nonmotor symptoms. The aim of this study was to investigate the relationship of OCT and visual evoked potentials (VEPs) of eyes with the severity
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Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Naïve Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2023-2-8 Jong Hyeon Ahn, Jin Whan Cho, Jinyoung Youn
Introduction. Fatigue and orthostatic hypotension (OH) are common and disabling nonmotor symptoms (NMSs) of Parkinson’s disease (PD), but none of the studies have reported on the longitudinal association between fatigue and OH. Methods. Drug-naïve PD patients were recruited from a hospital-based cohort and evaluated with the Parkinson Fatigue Scale (PFS), head-up tilt test, Unified PD Rating Scale
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The Lived Experience of Caregiving and Perception of Service Provision among Family-Caregivers of People with Late-Stage Parkinson’s: A Qualitative Study Parkinson's Dis. (IF 3.2) Pub Date : 2023-2-3 Joy Read, Sarah Cable, Gergely Bartl, Charlotte Löfqvist, Susanne Iwarsson, Anette Schrag
Background. The complex nature of late-stage Parkinson’s requires multiagency support and leads to an increased burden on family members who assume a multiplicity of responsibilities. The aim of this study is to further understand the lived experiences of family-caregivers and their perception of, and satisfaction with, service provision. Methods. This qualitative substudy was a part of the European
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Exploring a New Cueing Device in People Who Experience Freezing of Gait: Acceptance of a Study Design Parkinson's Dis. (IF 3.2) Pub Date : 2022-12-7 Agnes Wilhelm, Tanja Riedl, Christian Paumann, Jessie Janssen
Background. Freezing of Gait (FoG) is a disabling symptom of Parkinson’s Disease (PD) and is defined as a “brief episodic absence or marked reduction of forward progression of the feet despite the intention to walk.” Compensatory strategies such as cueing and high frequency vibrotactile stimulation can reduce FoG severity and improve gait parameters. A new Sternal high frequency Vibrotactile Stimulation
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Impact of Off-Time on Quality of Life in Parkinson’s Patients and Their Caregivers: Insights from Social Media Parkinson's Dis. (IF 3.2) Pub Date : 2022-12-3 Philippe Damier, Emily J. Henderson, Jesús Romero-Imbroda, Laura Galimam, Nick Kronfeld, Tobias Warnecke
Introduction. In Parkinson’s disease (PD), the quality of life of both patients and caregivers is affected. While key issues relating to quality of life may not emerge in conversations with healthcare professionals (HCPs), unguarded social media conversations can provide insight into how people with Parkinson’s disease (PwPD) and their caregivers are affected. We conducted a qualitative and quantitative
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Onset of Postural Instability in Parkinson’s Disease Depends on Age rather than Disease Duration Parkinson's Dis. (IF 3.2) Pub Date : 2022-12-2 Denise Becker, Angelina Maric, Simon J. Schreiner, Fabian Büchele, Christian R. Baumann, Daniel Waldvogel
Background. Postural instability and falls are considered a major factor of impaired quality of life in patients with advanced Parkinson’s disease (PD). The knowledge of the time at which postural instability occurs will help to provide the evidence required to introduce fall-prevention strategies at the right time in PD. Objective. To investigate whether postural instability of patients with different
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Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia Parkinson's Dis. (IF 3.2) Pub Date : 2022-11-29 Yu-Ting Ling, Qian-Qian Guo, Si-Min Wang, Li-Nan Zhang, Jin-Hua Chen, Yi Liu, Ruo-Heng Xuan, Bo Qu, Li-Ge Liu, Zhi-Shuang Wen, Jia-Kun Xu, Lu-Lu Jiang, Wen-Biao Xian, Bin Wu, Chang-Ming Zhang, Ling Chen, Jin-Long Liu, Nan Jiang
Introduction. Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson’s disease. The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. Methods. We conducted a retrospective observational cohort study on
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Impact of Gastrointestinal Symptoms on Health-Related Quality of Life in an Australian Parkinson’s Disease Cohort Parkinson's Dis. (IF 3.2) Pub Date : 2022-11-25 Jade E. Kenna, Megan C. Bakeberg, Maddison Y. Abonnel, Frank L. Mastaglia, Ryan S. Anderton
Background. Gastrointestinal symptoms (GIS) in people with Parkinson’s disease (PwP) are often underreported and may remain untreated. Constipation is a common nonmotor symptom that can adversely affect health-related quality of life (QoL); however, the impact of other GIS has not been adequately investigated. Objectives. To investigate the relationship between QoL and constipation using the Bristol
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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model Parkinson's Dis. (IF 3.2) Pub Date : 2022-11-14 Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher
Insulin desensitization has been observed in the brains of patients with Parkinson’s disease (PD), which is a progressive neurodegenerative disorder for which there is no cure. Semaglutide is a novel long-actingglucagon-likepeptide-1 (GLP-1) receptor agonist that is on the market as a treatment for type 2 diabetes. It is in a phase II clinical trial in patients with PD. Two previous phase II trials
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Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-11-9 Jincheol Seo, Kyung Seob Lim, Chang-Yeop Jeon, SeungHo Baek, Hyeon-Gu Yeo, Won Seok Choi, Sung-Hyun Park, Kang Jin Jeong, Jinyoung Won, Keonwoo Kim, Junghyung Park, Jiyeon Cho, Jung Bae Seong, Minji Kim, Yu Gyeong Kim, Jae-Won Huh, Samhwan Kim, Yong Hoon Lim, Hyung Woo Park, Hye Min Tak, Man Seong Heo, Ji-Woong Choi, Sun Ha Paek, Youngjeon Lee
The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To
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Effects of Levodopa-Carbidopa Intestinal Gel Compared with Optimized Medical Treatment on Nonmotor Symptoms in Advanced Parkinson’s Disease: INSIGHTS Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-11-4 Sun Ju Chung, Matilde Calopa, Maria G. Ceravolo, Nicola Tambasco, Angelo Antonini, K. Ray Chaudhuri, Weining Z. Robieson, Olga Sánchez-Soliño, Cindy Zadikoff, Man Jin, Luigi M. Barbato
Background. Nonmotor symptoms (NMS) are common in advanced Parkinson’s disease (APD) and reduce health-related quality of life. Objective. The aim of the study was to evaluate levodopa-carbidopa intestinal gel (LCIG) versus optimized medical treatment (OMT) on NMS in APD. Methods. INSIGHTS was a phase 3b, open-label, randomized, multicenter study in patients with APD (LCIG or OMT, 26 weeks) (NCT02549092)
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Resistance Training Combined with Balance or Gait Training for Patients with Parkinson’s Disease: A Randomized Controlled Pilot Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-10-7 Johanna Theresia Biebl, Monica Azqueta-Gavaldon, Cornelia Wania, Olena Zettl, Matthias Woiczinski, Leandra Bauer, Claudia Storz, Kai Bötzel, Eduard Kraft
Background. Gait and balance disorders in patients with idiopathic Parkinson’s disease (PD) lead to major mobility limitations. To counteract this, physical therapy such as gait, balance, or resistance training is applied. Integrative training methods, which combine these elements, could be particularly effective. Objective. The objective of this study is to evaluate and compare the effects of two
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Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus and Globus Pallidus Internus in Parkinson’s Disease: A Meta-Analysis Parkinson's Dis. (IF 3.2) Pub Date : 2022-10-3 Song Zhang, Shumei Zi, Sihuai Xiong, Heng Peng, Kejia Hu, Hua He
Parkinson’s disease (PD) is a progressive neurodegenerative disorder typically manifested by its motor symptoms. In addition, PD patients also suffer from many nonmotor symptoms (NMSs), such as apathy. Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the globus pallidus internus (GPi) are recommended as therapeutic interventions for PD, given their pronounced benefit in reducing
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Like a Wave in Its Variable Shape, Breadth, and Depth: A Qualitative Interview Study of Experiences of Daytime Sleepiness in People with Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2022-9-27 Arja Höglund, Peter Hagell, Ulrika Östlund, Sten Fredrikson, Christina Sandlund
Introduction. Daytime sleepiness is a common nonmotor symptom in Parkinson’s disease (PD) which is associated with decreased quality of life and perceived health. However, experiences of daytime sleepiness in people with PD have not been explored. The aim of this qualitative study was to explore experiences of daytime sleepiness in people with PD. Materials and Methods. Five women and seven men (42–82
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Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2022-09-05 Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang
Parkinson’s disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis is not completely understood. Increasing evidence indicates that microRNAs (miRNAs) play a critical regulatory role in the pathogenesis of PD. This study aimed to explore the miRNA-mRNA regulatory network for PD. The differentially expressed miRNAs (DEmis) and genes (DEGs) between PD patients
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The Anti-Inflammatory Effect of Preventive Intervention with Ketogenic Diet Mediated by the Histone Acetylation of mGluR5 Promotor Region in Rat Parkinson’s Disease Model: A Dual-Tracer PET Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-09-05 Yuankai Zhu, Xiangyu Tang, Zhaoting Cheng, Qingjian Dong, Ge Ruan
Background and Objectives. The exact pathological mechanism of Parkinson’s disease (PD) remains elusive, and the existing therapies fail to reverse the disease progression. This study intended to explore the epigenetic anti-inflammatory mechanism of ketogenic diet (KD). Materials and Methods. The neuroprotective effect of ketosis state prior to the onset of PD (preventive KD, KDp) was compared with
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Effects of an Aquatic Physical Exercise Program on Ventilatory Parameters in People with Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2022-08-31 Bruna Yamaguchi, Dielise Debona Iucksch, Luis Henrique Paladini, Vera Lúcia Israel
Problems in the respiratory system are the main cause of death in Parkinson’s disease (PD). Ventilatory limitations can also be part of a vicious cycle involving physical-functional limitations (e.g., walking difficulties) and the patients’ perception of fatigue. The objective of this study was to analyze the effects of an aquatic physical exercise intervention program on ventilatory parameters, perception
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Rasagiline as Adjunct to Levodopa for Treatment of Parkinson’s Disease: A Systematic Review and Meta-Analysis Parkinson's Dis. (IF 3.2) Pub Date : 2022-08-30 Osamu Kano, Hiroshi Tsuda, Ayako Hayashi, Masaki Arai
Background. Rasagiline is a selective, irreversible monoamine oxidase type B inhibitor used as monotherapy in early Parkinson’s disease and as an adjunct therapy to levodopa in Parkinson’s disease with motor fluctuations. Objectives. This meta-analysis aimed to provide updated evidence on the efficacy for motor and nonmotor symptoms and the safety of rasagiline/levodopa versus levodopa in patients
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Short-Term Motor Outcomes in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-08-12 Kazunori Sato, Yoshihide Hokari, Eriko Kitahara, Nana Izawa, Kozo Hatori, Kaoru Honaga, Genko Oyama, Taku Hatano, Hirokazu Iwamuro, Atsushi Umemura, Yasushi Shimo, Nobutaka Hattori, Toshiyuki Fujiwara
Background. The effects of subthalamic nuclear deep brain stimulation therapy (STN-DBS) and combined postoperative rehabilitation for patients with Parkinson’s disease with postural instability have yet to be well reported. This study investigated the effects of short-term postoperative rehabilitation with STN-DBS on physical function in patients with Parkinson’s disease. Methods. Patients diagnosed
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Telerehabilitation: A Practical Remote Alternative for Coaching and Monitoring Physical Kinetic Therapy in Patients with Mild and Moderate Disabling Parkinson’s Disease during the COVID-19 Pandemic Parkinson's Dis. (IF 3.2) Pub Date : 2022-08-08 Aurelian Anghelescu
Background. The COVID-19 pandemic imposed social/physical distancing, lockdown measures, and forced reorientation of the rehabilitation programs for people with Parkinson’s disease (PD). Epidemiologic safety measures boosted remote exercise-based treatment. Objectives. Remote delivery of rehabilitation care services is not typically used in our department. Therefore, this study aimed to assess and
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Collective Expert Perspectives on the Use of Safinamide as Adjunctive Therapy for Parkinson’s Disease: Online-Based Delphi Survey Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-15 Atsushi Takeda, Yoshio Tsuboi, Masahiro Nomoto, Hideki Mochizuki, Nobutaka Hattori
Background. Safinamide is a selective, reversible monoamine oxidase-B inhibitor with a sodium channel inhibitory effect. Published clinical evidence supports safinamide as an effective therapy for Parkinson’s disease (PD) with wearing-off. However, to date, no consensus recommendations have been available to guide physicians in Asia on the optimal use of safinamide in clinical practice. To summarize
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Intestinal Transit in Early Moderate Parkinson’s Disease Correlates with Probable RBD: Subclinical Esophageal Dysmotility Does Not Correlate Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-15 Casper Skjærbæk, Karoline Knudsen, Martin Kinnerup, Kim Vang Hansen, Per Borghammer
Background. Nonmotor symptoms, including constipation and dysphagia, are very common in Parkinson’s disease (PD) and Lewy pathology is widespread in the gastrointestinal tract, particularly in the lower esophagus. Constipation and REM sleep behavior disorder (RBD) may present prior to clinical diagnosis. Yet, little is known about esophageal dysfunction and its connection to constipation in early PD
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Semaglutide Protects against 6-OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-13 Dong-xing Liu, Chen-sheng Zhao, Xiao-na Wei, Yi-peng Ma, Jian-kun Wu
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder for which no effective treatment is available. Studies have demonstrated that improving insulin resistance in type 2 diabetes mellitus (T2DM) can benefit patients with PD. In addition, a neuroprotective effect of glucagon-like peptide-1 (GLP-1) receptor agonists was demonstrated in experimental models of PD. In addition
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Occupational Therapy for People with Early Parkinson’s Disease: A Retrospective Program Evaluation Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-13 Alan Sadural, Jillian MacDonald, Joelle Johnson, Kavita Gohil, Miriam Rafferty
Purpose. Clinical practice guidelines establish that occupational therapy (OT) services are indicated for people with early Parkinson’s disease (PD). However, OT is uncommon compared to other rehabilitation services. This study describes the development and evaluation of a proactive, consultative OT program for people with early PD as a part of an integrated care approach. Materials and Methods. The
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Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-12 Mehmet Balal, Meltem Demirkiran, Saime Paydas
Background. Cardiovascular autonomic dysfunction, which leads to hemodynamic disorders, is commonly observed in patients with Parkinson’s disease (PD). Central aortic pressure (CAP) is the systolic blood pressure (SBP) at the root of the aorta. In young people, CAP is lower than peripheral arterial blood pressure. In older people, the difference between CAP and peripheral arterial blood pressure decreases
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Association between Baseline Cognitive Score and Postoperative Delirium in Parkinson’s Disease Patients following Deep Brain Stimulation Surgery Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-11 Yongde Zhou, Ting Fan, Yu Ma, Jian Ding, Jianfeng Yu, Yao Chen, Cuiping Yu, Rongsong Zhou, Baoguo Wang, Chengmei Shi
Background. Deep brain stimulation of the subthalamic nuclei (STN-DBS) is a standard treatment option for advanced Parkinson’s disease (PD) patients. Delirium following DBS electrode implantation is common, by several studies, and cognitive impairment is a risk factor for developing postoperative delirium (POD). This prospective observational study was conducted to identify whether preoperative baseline
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Clinical Features of Parkinson’s Disease in Patients with Early-Onset Freezing of Gait Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-08 Hiroo Terashi, Yuki Ueta, Takeshi Taguchi, Hiroshi Mitoma, Hitoshi Aizawa
Background. Freezing of gait (FOG) is an important symptom that can impair activities of daily living in patients with Parkinson’s disease (PD). However, its pathogenic mechanism is largely unknown. The aim of the present study was to elucidate the clinical characteristics of newly diagnosed and levodopa-naïve patients with PD who present with FOG. Methods. A total of 53 patients with untreated PD
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Nicotine Has a Therapeutic Window of Effectiveness in a Drosophila melanogaster Model of Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-08 Brady T. Mannett, Braden C. Capt, Krista Pearman, Lori M. Buhlman, John M. VandenBrooks, Gerald B. Call
Strong epidemiological evidence and studies in models of Parkinson’s disease (PD) suggest that nicotine may be therapeutically beneficial in PD patients. However, a number of clinical trials utilizing nicotine in PD patients have had mixed results, indicating that either nicotine is not beneficial in PD patients, or an important aspect of nicotine therapy was absent. We hypothesized that nicotine must
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Handgrip Strength and Anthropometry in Parkinson’s Disease at Diagnosis Parkinson's Dis. (IF 3.2) Pub Date : 2022-07-02 Lena Håglin, Birgitta Törnkvist, Mona Edström, Sofia Håglin, Lennart Bäckman
Objectives. To investigate how age, malnutrition, and the level of plasma cortisol and phosphate in patients with Parkinson’s disease (PD) at time of diagnosis are associated with body composition and handgrip strength in males and females compared to controls. Materials & Methods. This cross-sectional study includes baseline data from a cohort of newly diagnosed patients with Parkinson’s disease (N = 75;
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GuitarPD: A Randomized Pilot Study on the Impact of Nontraditional Guitar Instruction on Functional Movement and Well-Being in Parkinson’s Disease Parkinson's Dis. (IF 3.2) Pub Date : 2022-06-25 Serap Bastepe-Gray, Lavinia Wainwright, Diane C. Lanham, Gabriela Gomez, Jieung S Kim, Zane Forshee, Bonnie Kaas, Arita McCoy, Colin McGregor, Emile Moukheiber, Suraj Rajan, Gerson Suarez-Cedeno, Jiangxia Wang, Sean Brennan, Shane Coughlin, Kyurim Kang, Alexander Pantelyat
Playing musical instruments may have positive effects on motor, emotional, and cognitive deficits in patients with Parkinson’s disease (PD). This pilot study examined the feasibility of a six-week nontraditional guitar instruction program for individuals with PD. Twenty-six participants with idiopathic PD (Age: 67.22 ± 8.07; 17 males) were randomly assigned to two groups (intervention first or 6 weeks