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Antioxidant Combo Therapy Protects White Matter After Traumatic Brain Injury Neuromol. Med. (IF 2.629) Pub Date : 2021-01-23 Raghavendar Chandran, Suresh L. Mehta, Raghu Vemuganti
Following traumatic brain injury (TBI), increased production of reactive oxygen species (ROS) and the ensuing oxidative stress promotes the secondary brain damage that encompasses both grey matter and white matter. As this contributes to the long-term neurological deficits, decreasing oxidative stress during the acute period of TBI is beneficial. While NADPH oxidase (NOX2) is the major producer of
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Lipidomic Analysis of Postmortem Prefrontal Cortex Phospholipids Reveals Changes in Choline Plasmalogen Containing Docosahexaenoic Acid and Stearic Acid Between Cases With and Without Alzheimer’s Disease Neuromol. Med. (IF 2.629) Pub Date : 2021-01-21 Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa, Danielle J. Harvey, Lee-Way Jin, Britany N. Dugger, Ameer Y. Taha
Alzheimer’s disease (AD) is a progressive and incurable brain disorder that has been associated with structural changes in brain phospholipids (PLs), including diacyl species and ether-linked PLs known as plasmalogens. Most studies have characterized total changes in brain PL pools (e.g., choline plasmalogens), particularly in prefrontal cortex, but detailed and quantitative information on the molecular
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Extract of Polygala tenuifolia , Angelica tenuissima , and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson’s Disease Neuromol. Med. (IF 2.629) Pub Date : 2021-01-11 Huan Li, Joonki Kim, Huynh Nguyen Khanh Tran, Chang Hwan Lee, Jonghyun Hur, Min Cheol Kim, Hyun Ok Yang
The 20% ethanol extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan (WIN-1001X) was derived from a modified version of Korean traditional herbal formula ‘Chungsimyeolda-tang’ which has been used for the treatment of cerebrovascular disorders. The Parkinson’s disease presents with impaired motor functions and loss of dopaminergic neurons. However, the treatment for Parkinson’s
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VEGF Modulates the Neural Dynamics of Hippocampal Subregions in Chronic Global Cerebral Ischemia Rats Neuromol. Med. (IF 2.629) Pub Date : 2021-01-04 Ling Wang, Jiajia Yang, Xi Xiao, Chenguang Zheng, Dong Ming
Theta and gamma rhythms in hippocampus are important to cognitive performance. The cognitive impairments following cerebral ischemia is linked with the dysfunction of theta and gamma oscillations. As the primary mechanism for learning and memory, synaptic plasticity is in connection with these neural oscillations. Although vascular endothelial growth factor (VEGF) is thought to protect synaptic function
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LncRNA LINC00689 Promotes the Tumorigenesis of Glioma via Mediation of miR-526b-3p/IGF2BP1 Axis Neuromol. Med. (IF 2.629) Pub Date : 2021-01-03 Wen-Liang Zhan, Ning Gao, Guo-Long Tu, Hong Tang, Ling Gao, Ying Xia
Glioma ranks first among the aggressive brain tumors all over the world. LncRNA LINC00689 has been confirmed to play key roles in the progression of cancers, and LINC00689 was upregulated in glioma. However, the biological function of LINC00689 in glioma is unclear. qRT-PCR was applied to detect the expressions of LINC00689 and miR-526b-3p in glioma cells. Dual-luciferase report was performed to examine
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Neuronal Exosomes Secreted under Oxygen–Glucose Deprivation/Reperfusion Presenting Differentially Expressed miRNAs and Affecting Neuronal Survival and Neurite Outgrowth Neuromol. Med. (IF 2.629) Pub Date : 2021-01-03 Chien-Sung Chiang, Ssu-Ju Fu, Chia-Lang Hsu, Chung-Jiuan Jeng, Chih-Yung Tang, Yi-Shuian Huang, Sung-Chun Tang
Ischemia/reperfusion is a key feature of acute ischemic stroke, which causes neuron dysfunction and death. Exosomes, small extracellular vesicles produced by most cell types, are implicated in the mediation of cellular interactions with their environment. Here, we investigated the contents and functions of exosomes from neurons under ischemic reperfusion injury. First, rat cortical primary neuronal
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Proteomic Analysis of Perihematoma Tissue from Patients with Intracerebral Hemorrhage Using iTRAQ-Based Quantitative Proteomics Neuromol. Med. (IF 2.629) Pub Date : 2021-01-03 Bin Chen, Mingjian Liu, Zhenghong Chen, Xiaorong Gao, Yijun Cheng, Yongxu Wei, Zhebao Wu, Hanbing Shang
Intracerebral hemorrhage is a complicated disorder with limited proven prognostic and therapeutic targets and elusive mechanisms. With proteomic methods, we aimed to explore the global protein expression profile of perihematomal tissue from ICH patients and identify potential pathophysiological pathways and protein markers. Using iTRAQ-labeling quantitative proteomics technology, four ICH brain sample
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Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis Neuromol. Med. (IF 2.629) Pub Date : 2021-01-02 Haixia Jiang, Baiyuan Yang, Fang Wang, Kelu Li, Yongyun Zhu, Bin Liu, Hui Ren, Sijia Tian, Yanming Xu, Ailan Pang, Xinglong Yang
The aim of this study is to explore whether the single nucleotide polymorphism rs2275294 in the ZNF512B gene is related to the length of survival of patients with amyotrophic lateral sclerosis (ALS). This prospective study examined 212 patients with ALS, who were genotyped at the rs2275294 locus in ZNF512B using the ligase method. Genotype was compared with clinical data and survival. Kaplan–Meier
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High-Intensity Functional Training: Molecular Mechanisms and Benefits Neuromol. Med. (IF 2.629) Pub Date : 2021-01-01 Tavor Ben-Zeev, Eitan Okun
High-intensity interval training (HIIT) and strength exercise are known to improve health markers, such as cardiovascular health, metabolic health, and cognitive function, as well as to reduce all-cause mortality. High-Intensity Functional Training (HIFT) is a training paradigm derived from both HIIT and strength exercise to elicit greater muscle recruitment than repetitive aerobic exercises, thereby
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Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice Neuromol. Med. (IF 2.629) Pub Date : 2020-12-30 Sarah Ötzkan, Walter E. Muller, W. Gibson Wood, Gunter P. Eckert
Synaptic impairment may be the main cause of cognitive dysfunction in brain aging that is probably due to a reduction in synaptic contact between the axonal buttons and dendritic spines. Rho proteins including the small GTPase Rac1 have become key regulators of neuronal morphogenesis that supports synaptic plasticity. Small Rho- and Ras-GTPases are post-translationally modified by the isoprenoids geranylgeranyl
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A Walnut Diet in Combination with Enriched Environment Improves Cognitive Function and Affects Lipid Metabolites in Brain and Liver of Aged NMRI Mice Neuromol. Med. (IF 2.629) Pub Date : 2020-12-26 Carsten Esselun, Benjamin Dilberger, Carmina V. Silaidos, Elisabeth Koch, Nils Helge Schebb, Gunter P. Eckert
This in vivo study aimed to test if a diet enriched with 6% walnuts alone or in combination with physical activity supports healthy ageing by changing the oxylipin profile in brain and liver, improving motor function, cognition, and cerebral mitochondrial function. Female NMRI mice were fed a 6% walnut diet starting at an age of 12 months for 24 weeks. One group was additionally maintained in an enriched
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The Gut Ecosystem: A Critical Player in Stroke Neuromol. Med. (IF 2.629) Pub Date : 2020-11-18 Rosa Delgado Jiménez, Corinne Benakis
The intestinal microbiome is emerging as a critical factor in health and disease. The microbes, although spatially restricted to the gut, are communicating and modulating the function of distant organs such as the brain. Stroke and other neurological disorders are associated with a disrupted microbiota. In turn, stroke-induced dysbiosis has a major impact on the disease outcome by modulating the immune
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Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy Neuromol. Med. (IF 2.629) Pub Date : 2020-11-18 Anna K. Strosznajder, Sylwia Wójtowicz, Mieszko J. Jeżyna, Grace Y. Sun, Joanna B. Strosznajder
Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids, cholesterol, and sphingolipids. Similar to PPAR-α and PPAR-γ, PPAR-β/δ also acts as a transcription factor activated by dietary lipids and endogenous ligands, such as long-chain saturated and polyunsaturated fatty acids
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Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis Neuromol. Med. (IF 2.629) Pub Date : 2020-11-18 Teresa P. Easwaran, Nicola Lancki, Mario Henriquez, Alexander O. Vortmeyer, Nicholas M. Barbaro, Denise M. Scholtens, Atique U. Ahmed, Mahua Dey
Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular classification of gliomas is associated with preoperative seizure presentation and/or
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Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy Neuromol. Med. (IF 2.629) Pub Date : 2020-11-13 Muhammad Nadeem, Adam Kindelin, Laura Mahady, Kanchan Bhatia, Md Nasrul Hoda, Andrew F. Ducruet, Saif Ahmad
Traumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or direct injury to the optic nerve following blunt head trauma. TON is associated with increased oxidative stress and inflammation resulting in retinal ganglion cell (RGC) death. Remote ischemic post-conditioning (RIC) has been shown to enhance endogenous protective mechanisms in diverse disease models including
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Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment Neuromol. Med. (IF 2.629) Pub Date : 2020-11-12 Xin Ying Chua, Leona T. Y. Ho, Ping Xiang, Wee Siong Chew, Brenda Wan Shing Lam, Christopher P. Chen, Wei-Yi Ong, Mitchell K. P. Lai, Deron R. Herr
Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P1–S1P5. Scrutiny of S1P-regulated pathways over the past three decades has identified important and occasionally counteracting functions in the brain and cerebrovascular system. For example, while S1P1 and S1P3 mediate proinflammatory effects on glial cells and
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MiR-5787 Attenuates Macrophages-Mediated Inflammation by Targeting TLR4/NF-κB in Ischemic Cerebral Infarction Neuromol. Med. (IF 2.629) Pub Date : 2020-11-09 Zhicheng Bao, Shuguang Zhang, Xiaoliang Li
Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenesis of ischemic cerebral infarction. MiR-5787 is demonstrated to be downregulated in
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Lysophosphatidic Acid Signalling in Nervous System Development and Function Neuromol. Med. (IF 2.629) Pub Date : 2020-11-05 Eric Birgbauer
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G protein-coupled receptors (GPCRs) leading to a multitude of physiological responses. In this review, I describe our current understanding
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Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic-Ischemia Neonatal Rats and in Activated BV-2 Microglia Neuromol. Med. (IF 2.629) Pub Date : 2020-10-23 Jing Guo, Xiao-Li-Na Zhang, Zhang-Rui Bao, Xue-Ke Yang, Ling-Shuang Li, Yu Zi, Fan Li, Chun-Yun Wu, Juan-Juan Li, Yun Yuan
In response to hypoxic-ischemic brain damage (HIBD), microglia activation and its mediated inflammation contribute to neuronal damage. Inhibition of over-activated microglia is deemed to be a potential therapeutic strategy. Our previous studies showed that gastrodin efficiently depressed the neuroinflammation mediated by activated microglia in HIBD neonatal rats. The underlying mechanisms through which
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Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury Neuromol. Med. (IF 2.629) Pub Date : 2020-10-21 Xuan Kuo, Deron R. Herr, Wei-Yi Ong
Clinacanthus nutans (Lindau) (C. nutans) has diverse uses in traditional herbal medicine for treating skin rashes, insect and snake bites, lesions caused by herpes simplex virus, diabetes mellitus and gout in Singapore, Malaysia, Indonesia, Thailand and China. We previously showed that C. nutans has the ability to modulate the induction of cytosolic phospholipase A2 (cPLA2) expression in SH-SY5Y cells
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The Role of lncRNA TUG1 in the Parkinson Disease and Its Effect on Microglial Inflammatory Response Neuromol. Med. (IF 2.629) Pub Date : 2020-10-21 Jiang Cheng, Yangyang Duan, Fengting Zhang, Jin Shi, Hui Li, Feng Wang, Haining Li
Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and elderly populations. The purpose of this study was to investigate the clinical value of lncRNA TUG1 in PD and its effect on the microglial inflammatory response. A total of 181 subjects were recruited for the study, including 97 patients with PD (male/female 50/47) and 84 healthy individuals (male/female 41/43). There
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Galuteolin Inhibited Autophagy for Neuroprotection Against Transient Focal Cerebral Ischemia in Rats Neuromol. Med. (IF 2.629) Pub Date : 2020-10-21 Juxun Zhu, Liyun Wang, Jinping Zhang
Galuteolin, a Chinese herbal medicine, purified from Lonicera Japonica. In this study, we aimed to investigate the neuroprotective effect of galuteolin against cerebral ischemia/reperfusion (I/R) injury. We administered galuteolin or galuteolin and rapamycin to rats which had middle cerebral artery occlusion/reperfusion (MCAO/R). A series of characterizations were carried out to monitor the outcomes
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Bile Acids: A Communication Channel in the Gut-Brain Axis Neuromol. Med. (IF 2.629) Pub Date : 2020-10-21 Vera F. Monteiro-Cardoso, Maria Corlianò, Roshni R. Singaraja
Bile acids are signalling hormones involved in the regulation of several metabolic pathways. The ability of bile acids to bind and signal through their receptors is modulated by the gut microbiome, since the microbiome contributes to the regulation and synthesis of bile acids as well to their physiochemical properties. From the gut, bacteria have been shown to send signals to the central nervous system
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Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation Neuromol. Med. (IF 2.629) Pub Date : 2020-10-19 Anik Banerjee, Anil K. Chokkalla, Julia J. Shi, Juneyoung Lee, Venugopal Reddy Venna, Raghu Vemuganti, Louise D. McCullough
Social isolation (SI) increases ischemic injury and significantly delays recovery after experimental stroke. Changes in circulating microRNAs (miRNAs) have been implicated in several neurological disorders, including stroke. However, potential biomarkers to elucidate the mechanisms that underlie the detrimental effects of post-stroke isolation are unknown. Aged C57BL/6 male and female mice (18–20 months)
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CD137 Ligand-CD137 Interaction is Required For Inflammasome-Associated Brain Injury Following Ischemic Stroke Neuromol. Med. (IF 2.629) Pub Date : 2020-10-19 David Y. Fann, Emily Pauline Nickles, Luting Poh, Vismitha Rajeev, Sharmelee Selvaraji, Herbert Schwarz, Thiruma V. Arumugam
The CD137L-CD137 axis is a potent co-stimulatory immune checkpoint regulator that forms a bidirectional signaling pathway between the CD137 ligand (CD137L) and CD137 receptor to regulate immunological activities. This study investigated the potential involvement of the CD137L-CD137 axis on inflammasome-associated brain injury and neurological deficits in a mouse model of focal ischemic stroke. Cerebral
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Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury Neuromol. Med. (IF 2.629) Pub Date : 2020-10-16 Sally Shuxian Koh, Samantha Chia-Yi Ooi, Natalie Man-Yin Lui, Cao Qiong, Leona Ting-Yuke Ho, Irwin Kee-Mun Cheah, Barry Halliwell, Deron R. Herr, Wei-Yi Ong
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholesterol
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Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-κB-driven IL-1β Transcription Neuromol. Med. (IF 2.629) Pub Date : 2020-10-06 Mei-Han Kao, Jui-Sheng Wu, Wai-Mui Cheung, Jin-Jer Chen, Grace Y. Sun, Wei-Yi Ong, Deron R. Herr, Teng-Nan Lin
Neuroinflammation has been shown to exacerbate ischemic brain injury, and is considered as a prime target for the development of stroke therapies. Clinacanthus nutans Lindau (C. nutans) is widely used in traditional medicine for treating insect bites, viral infection and cancer, due largely to its anti-oxidative and anti-inflammatory properties. Recently, we reported that an ethanol extract from the
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Low Levels of LRRK2 Gene Expression are Associated with LRRK2 SNPs and Contribute to Parkinson’s Disease Progression Neuromol. Med. (IF 2.629) Pub Date : 2020-10-04 Selma Yılmazer, Esin Candaş, Gençer Genç, Merve Alaylıoğlu, Büşra Şengül, Ayşegül Gündüz, Hülya Apaydın, Güneş Kızıltan, Sibel Ertan, Erdinç Dursun, Duygu Gezen-Ak
Parkinson’s disease (PD) is a chronic neurodegenerative disease that has relatively slow progression with motor symptoms. Leucine-rich repeat kinase 2 (LRRK2) gene mutations and polymorphisms are suggested to be associated with PD. In this study, we aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of the LRRK2 gene, namely, rs11176013, rs10878371, rs11835105, and
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Preliminary Findings on Proline-Rich Protein 14 as a Diagnostic Biomarker for Parkinson’s Disease Neuromol. Med. (IF 2.629) Pub Date : 2020-10-01 Tao Jin, Xuling Tan, Xiaoliu Shi, Lingling Lv, Xinke Peng, Hainan Zhang, Beisha Tang, Chunyu Wang, Mei Yang
The nuclear envelope component proline-rich protein 14 (PRR14) is involved in the nuclear morphological alteration and activation of the mTOR (mammalian target of rapamycin) signaling pathway, and has been repeatedly shown to be upregulated in patients with Parkinson’s disease (PD). The aim of this study was to explore whether PRR14 can be used as a potential biomarker for the diagnosis of PD. We compared
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5-N-ethyl Carboxamidoadenosine Stimulates Adenosine-2b Receptor-Mediated Mitogen-Activated Protein Kinase Pathway to Improve Brain Mitochondrial Function in Amyloid Beta-Induced Cognitive Deficit Mice. Neuromol. Med. (IF 2.629) Pub Date : 2020-09-14 Bhupesh Chandra Semwal,Debapriya Garabadu
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss in memory as one of the cardinal features. 5-N-ethyl carboxamidoadenosine (NECA), an agonist of adenosine-2b receptor, exerts neuroprotective activity against several experimental conditions. Further, NECA activates mitogen-activated protein kinase (MAPK) and also attenuates mitochondrial toxicity in mammalian tissues other
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Docosahexaenoic Acid (DHA) Supplementation Alters Phospholipid Species and Lipid Peroxidation Products in Adult Mouse Brain, Heart, and Plasma. Neuromol. Med. (IF 2.629) Pub Date : 2020-09-14 Grace Y Sun,Michael K Appenteng,Runting Li,Taeseon Woo,Bo Yang,Chao Qin,Meixia Pan,Magdalena Cieślik,Jiankun Cui,Kevin L Fritsche,Zezong Gu,Matthew Will,David Beversdorf,Agata Adamczyk,Xianlin Han,C Michael Greenlief
The abundance of docosahexaenoic acid (DHA) in phospholipids in the brain and retina has generated interest to search for its role in mediating neurological functions. Besides the source of many oxylipins with pro-resolving properties, DHA also undergoes peroxidation, producing 4-hydroxyhexenal (4-HHE), although its function remains elusive. Despite wide dietary consumption, whether supplementation
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Oxytocin Reduces Brain Injury and Maintains Blood-Brain Barrier Integrity After Ischemic Stroke in Mice. Neuromol. Med. (IF 2.629) Pub Date : 2020-09-11 Shahein Momenabadi,Abbas Ali Vafaei,Ahmad Reza Bandegi,Mahdi Zahedi-Khorasani,Zohreh Mazaheri,Abedin Vakili
The present study was designed to determine the effect of different doses of oxytocin (OXT) on neuronal injury, spatial memory, blood-brain barrier (BBB) integrity and to explore possible underlying molecular mechanisms in the early stage of stroke in mice. Stroke model was generated by middle cerebral artery occlusion (MCAO) for 60 min and 24 h reperfusion in mice. OXT at doses of 1, 2, 4 and 8 IU/per
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Sphingosine 1-Phosphate Receptors in Cerebral Ischemia. Neuromol. Med. (IF 2.629) Pub Date : 2020-09-10 Bhakta Prasad Gaire,Ji Woong Choi
Sphingosine 1-phosphate (S1P) is an important lipid biomolecule that exerts pleiotropic cellular actions as it binds to and activates its five G-protein-coupled receptors, S1P1–5. Through these receptors, S1P can mediate diverse biological activities in both healthy and diseased conditions. S1P is produced by S1P-producing enzymes, sphingosine kinases (SphK1 and SphK2), and is abundantly present in
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HLA in Alzheimer's Disease: Genetic Association and Possible Pathogenic Roles. Neuromol. Med. (IF 2.629) Pub Date : 2020-09-07 Zi-Xuan Wang,Qi Wan,Ang Xing
Alzheimer’s disease (AD) is commonly considered as the most prominent dementing disorder globally and is characterized by the deposition of misfolded amyloid-β (Aβ) peptide and the aggregation of neurofibrillary tangles. Immunological disturbances and neuroinflammation, which result from abnormal immunological reactivations, are believed to be the primary stimulating factors triggering AD-like neuropathy
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Galectin-9 Promotes Neuronal Restoration via Binding TLR-4 in a Rat Intracerebral Hemorrhage Model. Neuromol. Med. (IF 2.629) Pub Date : 2020-08-31 Tianyu Liang,Cheng Ma,Tianyi Wang,Ruming Deng,Jiasheng Ding,Wenjie Wang,Zhongmou Xu,Xiang Li,Haiying Li,Qing Sun,Haitao Shen,Zhong Wang,Gang Chen
Intracerebral hemorrhage (ICH) is a devastating disease with high rates of mortality and morbidity. Galactose lectin-9 (Gal-9) belongs to the family of β-galactoside-binding lectins, which has been shown to play a vital role in immune tolerance and inflammation. However, the function of Gal-9 in ICH has not been fully studied in details. Several experiments were carried out to explore the role of Gal-9
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Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk. Neuromol. Med. (IF 2.629) Pub Date : 2020-08-29 Xiao Miao,Weifeng Liu,Bin Fan,Honghuang Lin
Alzheimer’s disease (AD) is a multifactorial disease that affects more than 5 million Americans. Multiple pathways might be involved in the AD pathogenesis. The implication of lipid genetic susceptibility on brain gene expression is yet to be investigated. The current study included 192 brain samples from AD patients who were enrolled in the ROSMAP study. The samples were genotyped and imputed to the
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Cell-Free Extracellular Vesicles Derived from Human Bone Marrow Endothelial Progenitor Cells as Potential Therapeutics for Microvascular Endothelium Restoration in ALS. Neuromol. Med. (IF 2.629) Pub Date : 2020-08-20 Svitlana Garbuzova-Davis,Alison E Willing,Jared Ehrhart,Lianchun Wang,Paul R Sanberg,Cesario V Borlongan
Repairing the damaged blood-CNS-barrier in amyotrophic lateral sclerosis (ALS) is necessary to prevent entry of detrimental blood-borne factors contributing to motor neuron dysfunction. Recently, we showed benefits of human bone marrow endothelial progenitor cell (hBM-EPC) transplantation into symptomatic ALS mice on barrier restoration by replacing damaged endothelial cells (ECs). Additionally, transplanted
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Quercetin Ameliorates CFA-Induced Chronic Inflammatory Hyperalgesia via Modulation of ROS-Mediated ERK1/2 Signaling and Inhibition of Spinal Glial Activation In Vivo. Neuromol. Med. (IF 2.629) Pub Date : 2020-08-19 Sanjay Kumar,Manjula Vinayak
Impact of reactive oxygen species (ROS) in development of hyperalgesia has recently motivated scientists to focus on ROS as novel target of anti-hyperalgesic interventions. Studies have indicated the usefulness of ROS scavengers and exogenous antioxidants as anti-nociceptive agents in animal models of neuropathic and inflammatory hyperalgesia. In present study, we suggest the anti-hyperalgesic potential
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MiR-874 Inhibits Cell Proliferation, Migration, and Invasion of Glioma Cells and Correlates with Prognosis of Glioma Patients. Neuromol. Med. (IF 2.629) Pub Date : 2020-08-14 Yongjuan Li,Xiaoyan Chen,Wei Xue,Junjun Liang,Liang Wang
Previous studies showed that miR-874 expression was abnormally expressed in many tumors. However, the potential role of miR-874 in glioma remains a mystery. This study aimed to investigate its expression, clinical significance, and cellular function in glioma. A total of 105 glioma patients were enrolled in the present study. The RT-qPCR analysis was used to detect the expression of miR-874 in glioma
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Blockage of miR-485-5p on Cortical Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation/Reoxygenation Through Inactivating MAPK Pathway. Neuromol. Med. (IF 2.629) Pub Date : 2020-07-27 Jiangliu Yin,Huan Chen,Suonan Li,Shuai Zhang,Xieli Guo
This study is designed to explore the role of miR-485-5p in hypoxia/reoxygenation-induced neuronal injury in primary rat cortical neurons. Hypoxia/reoxygenation model was established through oxygen and glucose deprivation/reoxygenation (OGD/R). RN-c cells were transfected with miR-485-5p mimics, miR-485-5p inhibitors, si-SOX6, pCNDA3.1-SOX6 or miR-485-5p + pCDNA3.1-SOX6, in which cell viability, apoptosis
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Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats. Neuromol. Med. (IF 2.629) Pub Date : 2020-07-07 Peixian Huang,Xuan Chen,Xiaoli Hu,Qiuping Zhou,Lanfen Lin,Shuqi Jiang,Hui Fu,Yajie Xiong,Hongke Zeng,Ming Fang,Chunbo Chen,Yiyu Deng
Neonatal sepsis is associated with cognitive deficit in the later life. Axonal myelination plays a pivotal role in neurotransmission and formation of learning and memory. This study aimed to explore if systemic lipopolysaccharide (LPS) injection would induce hypomyelination in the prefrontal cortex and hippocampus in developing septic neonatal rats. Sprague–Dawley rats (1-day old) were injected with
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A Tellurium-Based Small Immunomodulatory Molecule Ameliorates Depression-Like Behavior in Two Distinct Rat Models. Neuromol. Med. (IF 2.629) Pub Date : 2020-07-07 Moshe Hagar,Gersner Roman,Okun Eitan,Barnea-Ygael Noam,Zangen Abrham,Sredni Benjamin
Major depressive disorder (MDD) is a leading cause of morbidity, and the fourth leading cause of disease burden worldwide. While MDD is a treatable condition for many individuals, others suffer from treatment-resistant depression (TRD). Here, we suggest the immunomodulatory compound AS101 as novel therapeutic alternative. We previously showed in animal models that AS101 reduces anxiety-like behavior
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Application of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challenges. Neuromol. Med. (IF 2.629) Pub Date : 2020-05-12 Behrouz Shademan,Cigir Biray Avci,Masoud Nikanfar,Alireza Nourazarian
Genetic factors (gene mutations) lead to various rare and prevalent neurological diseases. Identification of underlying mutations in neurodegenerative diseases is of paramount importance due to the heterogeneous nature of the genome and different clinical manifestations. An early and accurate molecular diagnosis are cardinal for neurodegenerative patients to undergo proper therapeutic regimens. The
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miR-146a Mimics Ameliorates Traumatic Brain Injury Involving JNK and NF-κB Signaling Pathway. Neuromol. Med. (IF 2.629) Pub Date : 2020-05-09 Lei Zhang,Li Zhao,Wei Zhu,Yuexia Ding,Hongguang Chen,Nan Chi
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality among the world, while the advance of TBI management is rather limited in recent years. The deregulation of microRNAs (miRNAs) has been widely reported in TBI patients and animal models, and certain miRNAs have been identified as the emerging biomarkers of TBI. However, the role of miRNAs in the regulatory mechanism
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Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities. Neuromol. Med. (IF 2.629) Pub Date : 2020-05-08 Yuehong Yue,Hongwei Zhao,Yuanyuan Yue,Yang Zhang,Wanyi Wei
Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusion injuries, as well as its underlying mechanisms. Middle cerebral artery occlusion
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Correction to: High‑Mobility Group Box‑1‑Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model. Neuromol. Med. (IF 2.629) Pub Date : 2020-06-01 Shingo Nishihiro,Tomohito Hishikawa,Masafumi Hiramatsu,Naoya Kidani,Yu Takahashi,Satoshi Murai,Kenji Sugiu,Yusuke Higaki,Takao Yasuhara,Cesario V Borlongan,Isao Date
The original version of this article unfortunately contained a mistake. Figure 5a, b were incorrect. The correct figures are given below.
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Gnaq Protects PC12 Cells from Oxidative Damage by Activation of Nrf2 and Inhibition of NF-kB. Neuromol. Med. (IF 2.629) Pub Date : 2020-04-06 Xin Sun,Guo-Ping Li,Pu Huang,Lu-Gang Wei,Jia-Zhi Guo,Li-Juan Ao,Di Lu,Shao-Chun Chen
Reactive oxygen species (ROS) are continuously produced as byproducts of aerobic metabolism. Oxidative stress (OS) plays an important role in the occurrence of several neurodegenerative diseases as well as aging because of the accumulation of ROS. Gnaq is a member of G protein α subunits. It has been reported that the expression level of Gnaq in the mouse forebrain cortex was significantly decreased
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Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function. Neuromol. Med. (IF 2.629) Pub Date : 2020-03-31 Jun-Lin Liu,Shao-Qing Li,Feng Zhu,Yu-Xiang Zhang,Ya-Nan Wu,Jing-Si Yang,Bao Zhang,Chun-Xia Yan
Mounting evidence shows that drug dependence involves the complex interplay between genetics and the environment. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (DA) synthesis, which plays an essential role in the development of drug addiction. Noradrenergic dysfunction due to abnormalities TH expression has been implicated in the pathogenesis of drug addiction. We profiled thir
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Association of CHRNA5 Gene Variants with Crack Cocaine Addiction Neuromol. Med. (IF 2.629) Pub Date : 2020-03-10 Angelita P. Aroche; Diego L. Rovaris; Eugenio H. Grevet; Anderson R. Stolf; Breno Sanvicente-Vieira; Felix H. P. Kessler; Lisia von Diemen; Rodrigo Grassi-Oliveira; Claiton H. D. Bau; Jaqueline B. Schuch
Genome-wide studies provide increasing evidence of association of genetic variants with different behaviors. However, there is a growing need for replication and subsequent characterization of specific findings. In this sense, the CHRNA5 gene has been associated with nicotine (with genome-wide significance), alcohol and cocaine addictions. So far, this gene has not been evaluated in smoked (crack)
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Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway Neuromol. Med. (IF 2.629) Pub Date : 2020-03-05 Yu Qi; Huiting Jing; Xinhui Cheng; Tingxu Yan; Feng Xiao; Bo Wu; Kaishun Bi; Ying Jia
Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the Alpinia oxyphylla–Schisandra chinensis herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and
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Overexpression miR-486-3p Promoted by Allicin Enhances Temozolomide Sensitivity in Glioblastoma Via Targeting MGMT. Neuromol. Med. (IF 2.629) Pub Date : 2020-02-21 Henggang Wu,Xu Li,Tiehui Zhang,Guojun Zhang,Jingnan Chen,Li Chen,Min He,Bilie Hao,Cheng Wang
Glioblastoma is the most common primary tumor of the central nervous system that develops chemotherapy resistance. Previous studies showed that Allicin could inhibit multiple cancer cells including glioblastoma, but the function of Allicin in glioblastoma is still unclear. Our work aimed to investigate the underlying molecular mechanism. The results showed that miR-486-3p levels were greatly increased
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Correction to: Mild TBI Results in a Long-Term Decrease in Circulating Phospholipids in a Mouse Model of Injury. Neuromol. Med. (IF 2.629) Pub Date : 2020-06-01 Tanja Emmerich,Laila Abdullah,Joseph Ojo,Benoit Mouzon,Thinh Nguyen,Gogce Crynen,James E Evans,Jon Reed,Michael Mullan,Fiona Crawford
The original version of this article unfortunately contained a mistake. Gary S. Laco should not be listed as an author in the author group.
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Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway. Neuromol. Med. (IF 2.629) Pub Date : 2020-02-11 Jie Pang,Jiawei Hou,Zhangjiuzhi Zhou,Mengqiao Ren,Yuyan Mo,Guang Yang,Zuwei Qu,Yanli Hu
Alzheimer’s disease (AD) is a common neurodegenerative disease that is always accompanied by synaptic loss in the brain. Safflower yellow (SY) is the extract of safflower, a traditional Chinese medicine, which has shown neuroprotective effects in recent studies. However, the mechanism of SY in protecting synapses remains unclear. In this study, we are going to study the mechanism of how SY treats AD
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Impact of Maternal Separation on Dopamine System and its Association with Parkinson's Disease. Neuromol. Med. (IF 2.629) Pub Date : 2020-01-13 Kai-Jie He,Yu-Ting Zhang,Shi-Zhuang Wei,Shu-Min Jiang,Lin Xu,Chao Ren,Fen Wang
As a type of stress, maternal separation (MS) has been one of the most widely used models in neuropsychiatric research. An increasing number of studies has found that MS not only affects the function of the hypothalamic–pituitary–adrenal axis and hippocampal 5-hydroxytryptamine system, but also causes dysfunction of the central dopamine (DA) system and increases the susceptibility of dopaminergic neurons
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Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromol. Med. (IF 2.629) Pub Date : 2020-01-08 Debapriya Garabadu,Nidhi Agrawal
Parkinson’s disease (PD) is a neurodegenerative disease that is accompanied with the loss of dopaminergic neurons in the substantia nigra pars compacta which subsequently leads to a reduction in the dopamine level in the striatum. The flavonoids are gaining critical attention in the management of PD due to the toxic effects of the synthetic drugs. Naringin, a potent flavonoid, exerts neuroprotective
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A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury Neuromol. Med. (IF 2.629) Pub Date : 2020-01-08 Shiyu Luo, Haonan Xu, Yi Zuo, Xiaogang Liu, Angelo H. All
Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical reports from the past 5 years and evaluated the effects of various FES aided rehabilitation
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Ultrastructural Characteristics of DHA-Induced Pyroptosis. Neuromol. Med. (IF 2.629) Pub Date : 2020-01-04 Deron R Herr,Ting Yu Amelia Yam,Wan Shun Daniel Tan,Sally Shuxian Koh,Wai Shiu Fred Wong,Wei-Yi Ong,Kanokporn Chayaburakul
Microglial cells are resident macrophages of the central nervous system (CNS) that respond to bioactive lipids such as docosahexaenoic acid (DHA). Low micromolar concentrations of DHA typically promote anti-inflammatory functions of microglia, but higher concentrations result in a form of pro-inflammatory programmed cell death known as pyroptosis. This study used scanning electron microscopy (SEM)
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Mitochondrial DNA Copy Number in Peripheral Blood as a Potential Non-invasive Biomarker for Multiple Sclerosis. Neuromol. Med. (IF 2.629) Pub Date : 2020-01-04 Ghada Al-Kafaji,Halla F Bakheit,Maram A Alharbi,Ahmad A Farahat,Mohamed Jailani,Bashayer H Ebrahin,Moiz Bakhiet
The impaired mitochondrial function has been implicated in the pathogenicity of multiple sclerosis (MS), a chronic inflammatory, demyelinating, and neurodegenerative disease of the CNS. Circulating mtDNA copy number in body fluids has been proposed as an indicator for several neurodegenerative diseases, and the altered cerebrospinal fluid mtDNA has been shown as a promising marker for MS. The aim of
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Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury. Neuromol. Med. (IF 2.629) Pub Date : 2020-01-03 Garrett Ungerer,Jiankun Cui,Tina Ndam,Mikeala Bekemeier,Hailong Song,Runting Li,Heather R Siedhoff,Bo Yang,Michael K Appenteng,C Michael Greenlief,Dennis K Miller,Grace Y Sun,William R Folk,Zezong Gu
Spinal cord injury (SCI) is a deliberating disorder with impairments in locomotor deficits and incapacitating sensory abnormalities. Harpagophytum procumbens (Hp) is a botanical widely used for treating inflammation and pain related to various inflammatory and musculoskeletal conditions. Using a modified rodent contusion model of SCI, we explored the effects of this botanical on locomotor function
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