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Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder. Behav. Neurosci. (IF 1.9) Pub Date : 2024-01-18 Zahra Ghofrani-Jahromi, Sarah Nouri-Darehno, Mehrsa Rahimi-Danesh, Nastaran Talaee, Eghbal Jasemi, Ali Razmi, Salar Vaseghi
Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate potency whose principal active compounds are psilocybin and psilocin. Recent studies have shown the significant procognitive and mood-enhancer effects of Psilocybe cubensis. However, evidence is so limited, especially in preclinical studies. We aimed to investigate the effect of Psilocybe cubensis extract on posttraumatic
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Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test. Behav. Neurosci. (IF 1.9) Pub Date : 2023-12-21 David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec
Drug exposure during adolescence, when the "reward" circuitry of the brain is developing, can permanently impact reward-related behavior into adulthood. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently
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Predictions about reward outcomes in rhesus monkeys. Behav. Neurosci. (IF 1.9) Pub Date : 2023-12-07 Yiyun Huang, Hayoung Chang, Laurie R Santos, Alexandra G Rosati
Human infants and nonhuman animals respond to surprising events by looking longer at unexpected than expected situations. These looking responses provide core cognitive evidence that nonverbal minds make predictions about possible outcomes and detect when these predictions fail to match reality. We propose that this phenomenon has crucial parallels with the processes of reward prediction error, indexing
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Are reactions to frustrative nonreward in other animals a model for human anger? Neurobehavioral implications and therapeutic applications. Behav. Neurosci. (IF 1.9) Pub Date : 2023-10-30 M Potegal
Anger is a powerful and mostly deleterious emotion that can impair an individual's health and social relationships and that imposes considerable costs on society at large. It is a constituent of multiple psychopathologies, most notably intermittent explosive disorder. Excessive anger can drive injurious and even lethal reactive aggression. To understand its biobehavioral origins and develop appropriate
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Negative attributes of mixed-valence memories strengthen over long retention intervals and the degree of enhancement is predicted by individual differences in state anxiety. Behav. Neurosci. (IF 1.9) Pub Date : 2023-10-30 Louis D Matzel,Dylan W Crawford,Julia Bond,Kelsey M McKeen,Himali M Patel,Komal R Patel,Pranu Sharma,Ashley Swiecka,Alisha Tiwari
Memories are multifaceted and can simultaneously contain positive and negative attributes. Here, we report that negative attributes of a mixed-valence memory dominate long-term recall. To induce a mixed-valence memory, running responses were randomly reinforced with either food (∼83% of trials) or footshock (∼17% of trials), or a noise conditioned stimulus (CS) was followed randomly with either food
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Prelimbic cortex inactivation prevents ABA renewal based on stress state. Behav. Neurosci. (IF 1.9) Pub Date : 2023-10-12 Callum M P Thomas, Mark E Bouton, John T Green
Our recent research suggests that the interoceptive state associated with stress can function as a contextual stimulus for operant behavior. In the present experiment, we investigated the role of the rodent prelimbic cortex (PL), a brain region that is critical in contextual control of operant behavior, in the ability of a stressed state to produce ABA renewal of an extinguished operant response. Rats
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Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence? Behav. Neurosci. (IF 1.9) Pub Date : 2023-10-05 Lisa M Makowski, Stefan J Troche
The temporal resolution power (TRP) hypothesis states that individuals with higher TRP, as reflected by a higher performance on several psychophysical timing tasks, perform better on intelligence tests due to their ability to process information faster and coordinate their mental operations more effectively. It is proposed that these differences in TRP are related to the rate of a master clock based
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Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety. Behav. Neurosci. (IF 1.9) Pub Date : 2023-10-05 Kristina M Wright, Shannon Cieslewski, Amanda Chu, Michael A McDannald
Defensive responding is adaptive when it approximates the current threat but maladaptive when it exceeds the current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate levels of defensive responding in Pavlovian fear discrimination. Rats received bilateral transduction of the caudal substantia nigra with halorhodopsin or a control
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Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia. Behav. Neurosci. (IF 1.9) Pub Date : 2023-09-28 Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki
Previous studies have shown that low doses of ketamine, an N-methyl-D-aspartate receptor antagonist, produce aberrantly strong internal representations of associatively activated but absent stimuli in humans and nonhuman animals, suggesting the validity of ketamine treatment as a preclinical model of the positive symptoms of schizophrenia, including hallucinations and delusions. However, whether acute
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Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats. Behav. Neurosci. (IF 1.9) Pub Date : 2023-08-17 Xavier J Maddern,Andrew J Lawrence,Erin J Campbell
Maintaining abstinence and preventing relapse are key to the successful recovery from alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain from alcohol use: forced (e.g., incarceration) and voluntary. Voluntary abstinence is often evoked due to the negative consequences associated with excessive alcohol consumption. This study investigated relapse-like behavior
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Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama's 35th Avenue Superfund site. Behav. Neurosci. (IF 1.9) Pub Date : 2023-07-20 Kristen N Buford,Carly R Snidow,Tasha G Curiel,Heather E Dark,Juliann B Purcell,Devon K Grey,Sylvie Mrug,David C Knight
Exposure to environmental toxicants have serious implications for the general health and well-being of children, particularly during pivotal neurodevelopmental stages. The Environmental Protection Agency's (EPA) Superfund program has identified several areas (Superfund sites) across the United States with high levels of environmental toxicants, which affect the health of many residents in nearby communities
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Mental representations mediate aversive learning in humans. Behav. Neurosci. (IF 1.9) Pub Date : 2023-07-06 Xiaolin Qiao, Lauren Wolters, James D Howard
Mental representations of stimuli that are not physically present are critical for a range of cognitive capacities, including perception, memory, and learning. Overly robust mental representations, however, can contribute to hallucinations in healthy individuals and those diagnosed with psychotic illness. Measuring the strength of mental representations can thus provide insight into how the contents
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Proteome analysis indicates participation of the dorsal hippocampal formation in fear-motivated memory in a time-dependent manner. Behav. Neurosci. (IF 1.9) Pub Date : 2023-07-06 Renan Barretta Gaiardo, Amanda Paula Pedroso, Eliane Beraldi Ribeiro, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti
Our previous behavioral and molecular data indicate a central role of the dorsal hippocampal formation (dHF) in recent conditioned lick suppression memory. The purpose of this study was to investigate the role of the dHF in recent and remote memory of conditioned lick suppression employing proteomic analysis. Two or 40 days after conditioning, the rats were subjected to a retention test and were then
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Distinct competitive impacts of palatability of taste stimuli on sampling dynamics during a preference test. Behav. Neurosci. (IF 1.9) Pub Date : 2023-06-29 Benjamin Ballintyn, John Ksander, Donald B Katz, Paul Miller
Food or taste preference tests are analogous to naturalistic decisions in which the animal selects which stimuli to sample and for how long to sample them. The data acquired in such tests, the relative amounts of the alternative stimuli that are sampled and consumed, indicate the preference for each. While such preferences are typically recorded as a single quantity, an analysis of the ongoing sampling
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Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance. Behav. Neurosci. (IF 1.9) Pub Date : 2023-06-15 Samantha M Smith, Elena L Garcia, Anna Montelongo, Caroline G Davidson, Denna Bakhtiar, Sarah D Lovett, Andrew P Maurer, Sara N Burke
Improving cognitive health for older adults requires understanding the neurobiology of age-related cognitive decline and the mechanisms underlying preserved cognition in old age. During spatial learning tasks, aged humans and rodents shift navigation preferences in favor of a stimulus-response learning strategy. This has been hypothesized to result from competitive interactions of the caudate nucleus/dorsal
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A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice. Behav. Neurosci. (IF 1.9) Pub Date : 2023-06-15 Caitlyn J Bartsch, Sophia Aaflaq, Jessica T Jacobs, Molly Smith, Fletcher Summa, Savannah Skinner, Elana Qasem, Rylee Thompson, Zheng Li, Jacob C Nordman
Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in humans and has been proposed as a potential treatment for mood disorders such as posttraumatic stress disorder and aggression. However, previous studies from our lab and others have demonstrated that ketamine's effects are highly context- and dose-dependent. In a recent study, we found that 10 mg/kg ketamine
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The motivational role of the ventral striatum and amygdala in learning from gains and losses. Behav. Neurosci. (IF 1.9) Pub Date : 2023-05-04 Craig A Taswell,Miriam Janssen,Elisabeth A Murray,Bruno B Averbeck
The ventral striatum (VS) and amygdala are two structures often implicated as essential structures for learning. The literature addressing the contribution of these areas to learning, however, is not entirely consistent. We propose that these inconsistencies are due to learning environments and the effect they have on motivation. To differentiate aspects of learning from environmental factors that
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Ketamine facilitates appetitive trace conditioning in mice: Further evidence for abnormal stimulus representation in schizophrenia model animals. Behav. Neurosci. (IF 1.9) Pub Date : 2023-05-01 Riria Suzuki,Yutaka Kosaki
Recent studies indicated that positive symptoms of schizophrenia, such as hallucination and delusion, can be modeled using Pavlovian conditioning procedures. Various schizophrenia model animals exhibit abnormally strong associative activations of absent stimuli (i.e., conditioned hallucination) and readily form further associations involving the absent cues (i.e., enhanced mediated conditioning). In
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Prefrontal and medial temporal interactions in memory functions in the rhesus monkey. Behav. Neurosci. (IF 1.9) Pub Date : 2023-04-06 Laura A Welke, Tara L Moore, Douglas L Rosene, Ronald J Killiany, Mark B Moss
Both the medial temporal lobe and the dorsolateral prefrontal cortex have been implicated in learning and memory. However, it has been difficult to ascertain the degree to which the two structures are dependent on each other or interact in subserving these cognitive functions. To investigate this question directly, we prepared two group of monkeys. First, the contralateral frontal-hippocampal split
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The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats. Behav. Neurosci. (IF 1.9) Pub Date : 2023-03-06 Changjiu Zhao, Lauren V Riters
The medial preoptic area (MPOA) is well known for its role in sexual and maternal behaviors. This region also plays an important role in affiliative social behaviors outside reproductive contexts. We recently demonstrated that the MPOA is a central nucleus in which opioids govern highly rewarding social play behavior in adolescent rats. However, the neural circuit mechanisms underlying MPOA-mediated
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Maternal repetitive hypoxia prior to mating confers epigenetic resilience to memory impairment in male progeny. Behav. Neurosci. (IF 1.9) Pub Date : 2023-03-02 Emrey E Broyles,David H Corell,Jeffrey M Gidday
We showed previously in a mouse model of vascular cognitive impairment and dementia involving chronic cerebral hypoperfusion (CCH) that repetitive hypoxic conditioning (RHC) of both parents results in the epigenetic, intergenerational transmission of resilience to recognition memory loss in adult progeny, as assessed by the novel object recognition test. The present study was undertaken in the same
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Examination of onset trajectories and persistence of binge-like eating behavior in mice after intermittent palatable food exposure. Behav. Neurosci. (IF 1.9) Pub Date : 2023-02-23 Britny A Hildebrandt, Hayley Fisher, Susanne E Ahmari
Binge eating is a persistent behavior associated with a chronic course of illness and poor treatment outcomes. While clinical research is unable to capture the full course of binge eating, preclinical approaches offer the opportunity to examine binge-like eating from onset through chronic durations, allowing identification of factors contributing to binge eating persistence. The present study quantified
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The role of the anterior cingulate cortex in aggression and impulsivity. Behav. Neurosci. (IF 1.9) Pub Date : 2023-02-09 Ilias Chaibi, Otmane Bouchatta, Mohamed Bennis, Saadia Ba-M'hamed
Aggression is a complex social behavior that evolved in the context of defending a territory, fighting for limited resources, and competing for mates and protection. Although aggression considered as a negative or undesirable emotion is an essential part of many species' repertoire of social behaviors. For humans, the motivations, actions, and limits of aggressive acts are not always clear. However
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Chemogenetic activation of lateral habenula accelerates the extinction of the appetitive conditioned responses. Behav. Neurosci. (IF 1.9) Pub Date : 2023-02-09 Dong-Hee Kim, Bo-Ryoung Choi, In-Beom Jin, Jin-Ah Jeon, Sang-Pil Park, Jung-Soo Han
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated
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Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study. Behav. Neurosci. (IF 1.9) Pub Date : 2023-01-12 Ping Chen,Dirk E M Geurts,Jessica I Määttä,Ruben van den Bosch,Lieke Hofmans,Danae Papadopetraki,Hanneke den Ouden,Roshan Cools
Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([¹⁸F]-DOPA PET) in healthy participants (N = 100) to assess whether dopamine synthesis capacity (Ki), specifically in
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The effects of time horizon and guided choices on explore-exploit decisions in rodents. Behav. Neurosci. (IF 1.9) Pub Date : 2023-01-12 Siyu Wang,Blake Gerken,Julia R Wieland,Robert C Wilson,Jean-Marc Fellous
Humans and animals have to balance the need for exploring new options with exploiting known options that yield good outcomes. This tradeoff is known as the explore-exploit dilemma. To better understand the neural mechanisms underlying how humans and animals address the explore-exploit dilemma, a good animal behavioral model is critical. Most previous rodents explore-exploit studies used ethologically
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Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behav. Neurosci. (IF 1.9) Pub Date : 2022-12-22 João P F Kurita, Anderson H F F Leão, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, Débora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silva
Optimal levels of anxiety are critical to memory consolidation, but maladaptive anxiety can disrupt memory acquisition. Serotonergic activity within the amygdala influences both anxiety-like behavior and aversive memory consolidation. To evaluate the effects of serotoninergic manipulations within the basolateral amygdala (BLA) on anxiety-like behavior and aversive memory in rats tested in the plus-maze
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Use of magnetic resonance spectroscopy to explore metacognitive ability. Behav. Neurosci. (IF 1.9) Pub Date : 2022-12-15 Xueyan Zhang,Jun Li,Xiaomei Li
Previous studies have reported the importance of the precuneus in mediating metacognition and the prefrontal cortex in decision-making tasks. However, the mechanisms underlying metacognition remain to be fully elucidated. N-acetyl aspartate/creatine + phosphocreatine (NAA/Cr + PCr) is a putative neuronal marker level, which has been used in cognitive disorders. Long echo time proton magnetic resonance
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Primary rewards and aversive outcomes have comparable effects on attentional bias. Behav. Neurosci. (IF 1.9) Pub Date : 2022-12-15 Haena Kim,Brian A Anderson
Attention is biased toward stimuli previously associated with reward. The same is true for aversive conditioning; stimuli previously associated with an aversive outcome also bias attention, suggesting that motivational salience guides attention. Most research that supports this conclusion has manipulated monetary gain-a secondary reinforcer-for reward learning, and electric shocks-a primary punisher-for
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Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-18 Adam W Lester, Gianna A Jordan, Colton J Blum, Zachary P Philpot, Carol A Barnes
Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust impairments on a number of different spatial navigation tasks. There is some evidence that these navigation impairments are accompanied
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Lack of robust associations between prepandemic coping strategies and frontolimbic circuitry with depression and anxiety symptoms during the COVID-19 pandemic: A preregistered longitudinal study. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-18 Bailey Holt-Gosselin, Emily M Cohodes, Sarah McCauley, Jordan C Foster, Paola Odriozola, Sadie J Zacharek, Sahana Kribakaran, Jason T Haberman, H R Hodges, Dylan G Gee
The COVID-19 pandemic is an ongoing stressor that has resulted in the exacerbation of mental health problems worldwide. However, longitudinal studies that identify preexisting behavioral and neurobiological factors associated with mental health outcomes during the pandemic are lacking. Here, we examined associations between prepandemic coping strategy engagement and frontolimbic circuitry with internalizing
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Neuroscience research on human visual path integration: Topical review of the path completion paradigm and underlying role of the hippocampal formation from a strategic perspective. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-18 Jimmy Y Zhong
Over the past 30 years, numerous neuroscientific studies involving both human and rodent subjects have investigated the brain regions and networks supporting path integration and sought to identify the underlying neural mechanisms. Although these studies contributed to an increased understanding of path integration, a full picture of the brain mechanisms supporting path integration remains wanting
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Divergent effects of oral cannabis oil extracts marketed as C. indica or C. sativa on exertion of cognitive effort in rats. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-17 Hannah G Brodie, Brett A Hathaway, Andrew Li, Samantha L Baglot, Sukhbir Kaur, Matthew N Hill, Catharine A Winstanley
The main psychoactive compound within the cannabis plant, Δ9-tetrahydrocannabinol (THC), is thought to drive both the sensation of "high" and the cognitive impairments associated with cannabis consumption. Researchers keen to understand how cannabis impairs cognition have, therefore, studied the behavioral effects of systemic injections of THC in animal models. However, cannabis contains multiple other
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Choice-confirmation bias and gradual perseveration in human reinforcement learning. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-17 Stefano Palminteri
Do we preferentially learn from outcomes that confirm our choices? In recent years, we investigated this question in a series of studies implementing increasingly complex behavioral protocols. The learning rates fitted in experiments featuring partial or complete feedback, as well as free and forced choices, were systematically found to be consistent with a choice-confirmation bias. One of the prominent
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A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-14 S Mohammad Ahmadi-Soleimani,Hossein Azizi,Farimah Beheshti,Omid Azizi,Alireza Abbasi-Mazar
Adolescence is a critical life period during which significant neurodevelopmental changes occur within the central nervous system. Consistently, substance abuse in this stage has been found to induce persistent changes in brain responsiveness to future drug challenges. Nowadays, heavy episodic alcohol consumption during adolescence, also known as binge-drinking behavior, is a growing concern in modern
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Behavioral and neurochemical effects of nociceptin/orphanin FQ receptor activation in the social defeat protocol. Behav. Neurosci. (IF 1.9) Pub Date : 2022-11-03 Alice Barros Câmara, Igor Augusto Brandão
The nociceptin/orphanin FQ receptor (NOP receptor) has wide expression in the nervous system and is involved in neurotransmitter release. However, the role of the NOPR in depression is not widely recognized. This study aims to evaluate behavioral and biochemical effects of the NOPR agonist Ro 65-6570 in mice submitted to social defeat protocol. The open-field test, social interaction test, and tail
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Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. Behav. Neurosci. (IF 1.9) Pub Date : 2022-10-31 Ashley R Deane, Yu Jing, Reza Shoorangiz, Ping Liu, Ryan D Ward
As a hallmark characteristic of schizophrenia, abnormal perception of time is thought to arise from cognitive impairment; however, the absence of translational models indexing this pathological relationship creates barriers to understanding the functional and biological bases of timing impairments. Here, we investigate the relationship between timing and cognition using the maternal immune activation
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The role of goal-directed and habitual processes in food consumption under stress after outcome devaluation with taste aversion. Behav. Neurosci. (IF 1.9) Pub Date : 2022-10-03 Eike K Buabang, Yannick Boddez, Oliver T Wolf, Agnes Moors
People are more likely to engage in various suboptimal behaviors such as overeating, addictive behaviors, and short-sighted financial decision-making when they are under stress. Traditional dual-process models propose that stress can impair the ability to engage in goal-directed behavior so that people have to rely on habitual behavior. Support for this idea comes from a study by Schwabe and Wolf (2010)
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Pupillometry tracks errors in interval timing. Behav. Neurosci. (IF 1.9) Pub Date : 2022-10-01 Shamini Warda,Jaana Simola,Devin B Terhune
Recent primate studies suggest a potential link between pupil size and subjectively elapsed duration. Here, we sought to investigate the relationship between pupil size and perceived duration in human participants performing two temporal bisection tasks in the subsecond and suprasecond interval ranges. In the subsecond task, pupil diameter was greater during stimulus processing when shorter intervals
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A limited cerebellar contribution to suprasecond timing across differing task demands. Behav. Neurosci. (IF 1.9) Pub Date : 2022-10-01 Kelsey A Heslin,Jessica R Purnell,Benjamin J De Corte,Krystal L Parker
The involvement of the cerebellum in suprasecond interval timing (i.e., timing in the seconds to minutes range) is controversial. A limited amount of evidence from humans, nonhuman primates, and rodents has shown that the lateral cerebellum, including the lateral cerebellar nucleus (LCN), may be necessary for successful suprasecond timing performance. However, many existing studies have pitfalls, such
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Timing, neural timescales, and temporal cognition. Behav. Neurosci. (IF 1.9) Pub Date : 2022-10-01 Federico Sanabria,Angela Langdon,Alicia Izquierdo
This special issue provides a representative snapshot of cutting-edge behavioral neuroscience research on sense of time, cognitive and behavioral functioning, and neural processes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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Rhesus monkeys with damage to amygdala or orbitofrontal cortex perform well on novelty-based memory tasks. Behav. Neurosci. (IF 1.9) Pub Date : 2022-09-08 Joshua L Krasney, Joseph R Manns, Andrew M Kazama, Jocelyne Bachevalier
The amygdala and orbitofrontal cortex (OFC) are interconnected regions that serve as key nodes in brain circuits supporting social and affective behaviors. An important question that has come into focus is whether these regions also play a fundamental role in responding to novelty. One possibility is that these regions are important for discriminating novel from familiar stimuli. An alternative possibility
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Evaluation of baseline behavioral tests in ferrets. Behav. Neurosci. (IF 1.9) Pub Date : 2022-7-29 Adedunsola Obasa, Susan C Schwerin, Michael Ray, Michael Strayhorn, Sharon L Juliano
As the smallest mammal with a gyrencephalic cerebral cortex, ferrets are becoming increasingly important animal models to study neurological disorders. In order for them to be optimally used, typical behavioral measurements are highly desirable. To ascertain a baseline level of behavior, we conducted a battery of tests assessing motor, social, memory, headache, and aspects of depressive-like behavior
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Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats. Behav. Neurosci. (IF 1.9) Pub Date : 2022-07-28 Michelle A Frankot, Christopher M O'Hearn, Alyssa M Blancke, Bryan Rodriguez, Kristen M Pechacek, Jasleen Gandhi, Gangqing Hu, Kris M Martens, Cole Vonder Haar
The mechanisms underlying chronic psychiatric-like impairments after traumatic brain injury (TBI) are currently unknown. The goal of the present study was to assess the role of diet and the gut microbiome in psychiatric symptoms after TBI. Rats were randomly assigned to receive a high-fat diet (HFD) or calorie-matched low-fat diet (LFD). After 2 weeks of free access, rats began training on the rodent
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Event-related brain potentials of temporal generalization: The P300 span marks the transition between time perception and time estimation. Behav. Neurosci. (IF 1.9) Pub Date : 2022-07-14 Henning Gibbons
There has been a long-standing debate on where on the time axis the transition between time perception and time estimation (i.e., the cognitive reconstruction of time) can be located. According to Fraisse (1984), time perception applies to intervals < 300 ms, whereas intervals > 1 s are subject to time estimation. While there is good empirical evidence for this notion, it might be possible to further
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Quitting while you're ahead: Patch foraging and temporal cognition. Behav. Neurosci. (IF 1.9) Pub Date : 2022-07-14 Riley K Kendall, Andrew M Wikenheiser
Theoretical models of foraging are based on the maximization of food intake rate. Remarkably, foragers often hew close to the predictions of rate maximization, except for a frequently observed bias to remain in patches for too long. By sticking with depleting options beyond the optimal patch residence time-a phenomenon referred to as overharvesting or overstaying-foragers miss out on food they could
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mPFC catecholamines modulate attentional capture by appetitive distracters and attention to time in a peak-interval procedure in rats. Behav. Neurosci. (IF 1.9) Pub Date : 2022-07-14 Catalin V Buhusi, Alexander R Matthews, Mona Buhusi
The behavioral and neural mechanisms by which distracters delay interval timing behavior are currently unclear. Distracters delay timing in a considerable dynamic range: Some distracters have no effect on timing ("run"), whereas others seem to "stop" timing; some distracters restart ("reset") the entire timing mechanisms at their offset, whereas others seem to capture attentional resources long after
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The rostral medial frontal cortex is crucial for engagement in consummatory behavior. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-30 Samantha R White, Mark Laubach
The medial frontal cortex (MFC) in rodents emits rhythmic activity that is entrained to the animal's licking cycle during consumption and encodes the value of consumed fluids. These signals are especially prominent in the rostral half of the MFC. This region is located above an orbitofrontal region where mu-opioid receptors regulate intake and reversible inactivation reduces behavioral measures associated
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Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-30 S Alex Marshall, Stacey L Robinson, Suzahn E Ebert, Michel A Companion, Todd E Thiele
Repetitive bouts of binge drinking can lead to neuroplastic events that alter ethanol's pharmacologic effects and perpetuate excessive consumption. The corticotropin-releasing factor (CRF) system is an example of ethanol-induced neuroadaptations that drive excessive ethanol consumption. Our laboratory has previously shown that CRF antagonist, when infused into the central amygdala (CeA), reduces binge-like
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The temporal context in bayesian models of interval timing: Recent advances and future directions. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-23 Renata Sadibolova, Devin B Terhune
Sensory perception, motor control, and cognition necessitate reliable timing in the range of milliseconds to seconds, which implies the existence of a highly accurate timing system. Yet, partly owing to the fact that temporal processing is modulated by contextual factors, perceived time is not isomorphic to physical time. Temporal estimates exhibit regression to the mean of an interval distribution
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Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-09 David S Jacobs, Leah N Hitchcock, Rapheal G Williams, K Matthew Lattal
Studies of instrumental responding often include the delivery of a cue that is coincident with the delivery of the reinforcer. One purpose of this is for the cue to be removed during extinction and then presented later to assess whether responding returns (cue-induced reinstatement). In two experiments, we examined the effects of having a cue associated with reinforcement present or absent during extinction
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Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-06 Emily N Hilz, Marcelle E Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C Gore, Hongjoo J Lee
Hormonal contraceptives (HCs) containing synthetic ovarian hormones are commonly used among reproductive aged women; HCs alter the physiological state of the user by interfering with endogenous hormone concentrations and their actions on the reproductive tract. As ovarian hormones modulate the incidence of substance abuse disorders in women, this experiment explores how modulating female rat ovarian
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Time to contrast models of timing: The structure of temporal memory. Behav. Neurosci. (IF 1.9) Pub Date : 2022-06-02 Armando Machado, Marilia Pinheiro de Carvalho, Marco Vasconcelos
In the study of animal timing over the last 100 years, we identify three different periods, each characterized by a distinct activity. In the first period, researchers brought timing into the laboratory and explored its multiple expressions empirically. In the second period, the growing body of empirical findings inspired researchers to develop a plethora of timing models that vary in theoretical orientation
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Delay discounting in aging: The influence of cognitive and psychological variables. Behav. Neurosci. (IF 1.9) Pub Date : 2022-05-23 Inês Macedo, Carina Fernandes, Fernando Barbosa, João Marques-Teixeira
Delay discounting (or temporal discounting) refers to the decrease of the subjective value of a reward as the time interval for receiving that reward increases. A recent meta-analysis showed that delay discounting appears to be similar across the lifespan as younger, middle-aged, and older adults prefer sooner rewards, despite smaller, over later rewards, even if larger. However further investigation
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Are observed effects of movement simulated during motor imagery performance? Behav. Neurosci. (IF 1.9) Pub Date : 2022-5-20 Jack P Solomon, Austin J Hurst, JungWoo Lee, Shaun G Boe
Motor learning relies on adjusting the performance of movements via error detection and correction. How motor learning proceeds via motor imagery, the imagination of movement, is not understood. Motor imagery-based learning is thought to rely on comparing the predicted effect of movement, resulting from the forward model, against its intended effect. Whether motor imagery-based learning uses the observed
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How do real animals account for the passage of time during associative learning? Behav. Neurosci. (IF 1.9) Pub Date : 2022-04-28 Vijay Mohan K Namboodiri
Animals routinely learn to associate environmental stimuli and self-generated actions with their outcomes such as rewards. One of the most popular theoretical models of such learning is the reinforcement learning (RL) framework. The simplest form of RL, model-free RL, is widely applied to explain animal behavior in numerous neuroscientific studies. More complex RL versions assume that animals build
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Neural population clocks: Encoding time in dynamic patterns of neural activity. Behav. Neurosci. (IF 1.9) Pub Date : 2022-04-21 Shanglin Zhou, Dean V Buonomano
The ability to predict and prepare for near- and far-future events is among the most fundamental computations the brain performs. Because of the importance of time for prediction and sensorimotor processing, the brain has evolved multiple mechanisms to tell and encode time across scales ranging from microseconds to days and beyond. Converging experimental and computational data indicate that, on the
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Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory. Behav. Neurosci. (IF 1.9) Pub Date : 2022-04-07 Matthew A Weber, Mackenzie M Conlon, Hannah R Stutt, Linder Wendt, Patrick Ten Eyck, Nandakumar S Narayanan
Dopamine in the prefrontal cortex can be disrupted in human disorders that affect cognitive function such as Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and schizophrenia. Dopamine has a powerful effect on prefrontal circuits via the D1-type dopamine receptor (D1DR). It has been proposed that prefrontal dopamine has "inverted U-shaped" dynamics, with optimal dopamine
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Delayed but not immediate effects of estrogen curtail gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell. Behav. Neurosci. (IF 1.9) Pub Date : 2022-04-07 Julio C Diaz, Kate Dunaway, Elizabeth Sheil, Ken Sadeghian, Anthony Auger, Brian A Baldo
The present study investigated immediate versus delayed effects of estrogen replacement in ovariectomized (OVX) rats on hyperphagia elicited by gamma-aminobutyric acid (GABA)-A-agonist (muscimol) infusions into the nucleus accumbens shell (AcbSh). First, because intra-AcbSh muscimol-induced feeding has never been explored in OVX rats, a dose-effect curve was generated and compared to sham-operated
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Serotonergic modulation of appetitive and ingestive behavior in crayfish. Behav. Neurosci. (IF 1.9) Pub Date : 2022-03-31 Ann Jane Tierney, Madelyn Haller, Leah Grossman, Hannah Grote, Natalie Marcus-Bauer
Serotonin is an important modulator of feeding behavior across animal species. In invertebrates, much is known about the regulation of feeding in several model organisms, but comparative data are limited. We examined the modulation of feeding behavior in crayfish by administering serotonin and two serotonin receptor ligands, mianserin and 5-carboxamidotryptamine. We found that, compared to control