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An automatic system for recognizing fly courtship patterns via an image processing method Behav. Brain Funct. (IF 5.1) Pub Date : 2024-03-16 Ching-Hsin Chen, Yu-Chiao Lin, Sheng-Hao Wang, Tsung-Han Kuo, Hung-Yin Tsai
Fruit fly courtship behaviors composed of a series of actions have always been an important model for behavioral research. While most related studies have focused only on total courtship behaviors, specific courtship elements have often been underestimated. Identifying these courtship element details is extremely labor intensive and would largely benefit from an automatic recognition system. To address
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Changes in effective connectivity during the visual-motor integration tasks: a preliminary f-NIRS study Behav. Brain Funct. (IF 5.1) Pub Date : 2024-03-11 Wenchen Wang, Haimei Li, Yufeng Wang, Lu Liu, Qiujin Qian
Visual-motor integration (VMI) is an essential skill in daily life. The present study aimed to use functional near-infrared spectroscopy (fNIRS) technology to explore the effective connectivity (EC) changes among brain regions during VMI activities of varying difficulty levels. A total of 17 healthy participants were recruited for the study. Continuous Performance Test (CPT), Behavior Rating Inventory
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The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats Behav. Brain Funct. (IF 5.1) Pub Date : 2024-02-27 Jana Tchekalarova, Desislava Krushovlieva, Petj Ivanova, Zlatina Nenchovska, Gergana Toteva, Milena Atanasova
Aging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The present study aimed to explore the impact of plasma melatonin deficiency on anxiety responses and the possible involvement of the hypothalamic-pituitary-adrenocortical (HPA) axis and heat shock proteins (Hsp) 70 and 90 in the frontal cortex (FC) and the hippocampus
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Structural connectome alterations between individuals with autism and neurotypical controls using feature representation learning Behav. Brain Funct. (IF 5.1) Pub Date : 2024-01-24 Yurim Jang, Hyoungshin Choi, Seulki Yoo, Hyunjin Park, Bo-yong Park
Autism spectrum disorder is one of the most common neurodevelopmental conditions associated with sensory and social communication impairments. Previous neuroimaging studies reported that atypical nodal- or network-level functional brain organization in individuals with autism was associated with autistic behaviors. Although dimensionality reduction techniques have the potential to uncover new biomarkers
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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence Behav. Brain Funct. (IF 5.1) Pub Date : 2024-01-13 Baeksun Kim, Heh-In Im
Clinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead to early manifestation of withdrawal-like signs, indicating the state of “acute dependence”. As drug withdrawal is a major factor driving the progression toward regular drug intake, characterizing and understanding the features of early nicotine withdrawal may be
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Functional connectivity patterns in parosmia Behav. Brain Funct. (IF 5.1) Pub Date : 2023-12-19 Divesh Thaploo, Akshita Joshi, Eren Yilmaz, Duzgun Yildirim, Aytug Altundag, Thomas Hummel
Parosmia is a qualitative olfactory dysfunction presenting as “distorted odor perception” in presence of an odor source. Aim of this study was to use resting state functional connectivity to gain more information on the alteration of olfactory processing at the level of the central nervous system level. A cross sectional study was performed in 145 patients with parosmia (age range 20–76 years; 90 women)
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Inhibition of astroglial hemichannels ameliorates infrasonic noise induced short-term learning and memory impairment Behav. Brain Funct. (IF 5.1) Pub Date : 2023-12-18 Wei Zhang, Jue Yin, Bei-Yao Gao, Xi Lu, Ya-Jing Duan, Xu-Yan Liu, Ming-Zhen Li, Shan Jiang
As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research has shown that infrasound impairs cognitive function, especially the ability for learning and memory. Previously, we demonstrated that impaired learning and memory induced by infrasound was closely related with glia activation; however, the underlying mechanisms remain unclear. Connexin
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Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume Behav. Brain Funct. (IF 5.1) Pub Date : 2023-12-13 Wei Li, Qian Li, Peng Zhang, Huaigui Liu, Zhaoxiang Ye
Childhood trauma is one of the most extensively studied and well-supported environmental risk factors for the development of mental health problems. The human tryptophan hydroxylase 2 (TPH2) gene is one of the most promising candidate genes in numerous psychiatric disorders. However, it is now widely acknowledged that neither genetic variation nor environmental exposure alone can fully explain all
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Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait Behav. Brain Funct. (IF 5.1) Pub Date : 2023-12-01 Kun Deng, Weipeng Jin, Keying Jiang, Zixi Li, Hohjin Im, Shuning Chen, Hanxiao Du, Shunping Guan, Wei Ge, Chuqiao Wei, Bin Zhang, Pinchun Wang, Guang Zhao, Chunhui Chen, Liqing Liu, Qiang Wang
This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional connectivity analyses (ntotal = 452). In Cohort 1 (n = 83), task-based functional magnetic resonance imaging (t-fMRI) results from a region-of-interest (ROI) analysis revealed no direct correlation between amygdala reactivity to fearful and angry faces and GPT
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Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder Behav. Brain Funct. (IF 5.1) Pub Date : 2023-11-20 Juan Liu, Qian-Rong Liu, Zhao-Min Wu, Qiao-Ru Chen, Jing Chen, Yuan Wang, Xiao-Lan Cao, Mei-Xia Dai, Chao Dong, Qiao Liu, Jun Zhu, Lin-Lin Zhang, Ying Li, Yu-Feng Wang, Lu Liu, Bin-Rang Yang
Autistic traits (ATs) are frequently reported in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to examine ATs in children with ADHD from both behavioral and neuroimaging perspectives. We used the Autism Spectrum Screening Questionnaire (ASSQ) to assess and define subjects with and without ATs. For behavioral analyses, 67 children with ADHD and ATs (ADHD + ATs), 105
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Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats Behav. Brain Funct. (IF 5.1) Pub Date : 2023-11-06 Elena Martín-González, Ángeles Prados-Pardo, Stephen J. Sawiak, Jeffrey W. Dalley, Daniel Padro, Pedro Ramos-Cabrer, Santiago Mora, Margarita Moreno-Montoya
Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior
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Multivariate multiscale entropy (mMSE) as a tool for understanding the resting-state EEG signal dynamics: the spatial distribution and sex/gender-related differences Behav. Brain Funct. (IF 5.1) Pub Date : 2023-10-05 Monika Lewandowska, Krzysztof Tołpa, Jacek Rogala, Tomasz Piotrowski, Joanna Dreszer
The study aimed to determine how the resting-state EEG (rsEEG) complexity changes both over time and space (channels). The complexity of rsEEG and its sex/gender differences were examined using the multivariate Multiscale Entropy (mMSE) in 95 healthy adults. Following the probability maps (Giacometti et al. in J Neurosci Methods 229:84–96, 2014), channel sets have been identified that correspond to
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Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study Behav. Brain Funct. (IF 5.1) Pub Date : 2023-10-02 Qiao Wang, Shimin Hu, Lei Qi, Xiaopeng Wang, Guangyuan Jin, Di Wu, Yuke Wang, Liankun Ren
Emerging evidence suggests bidirectional causal relationships between sleep disturbance and psychiatric disorders, but the underlying mechanisms remain unclear. Understanding the bidirectional causality between sleep traits and brain imaging-derived phenotypes (IDPs) will help elucidate the mechanisms. Although previous studies have identified a range of structural differences in the brains of individuals
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Well-being is associated with cortical thickness network topology of human brain Behav. Brain Funct. (IF 5.1) Pub Date : 2023-09-25 Yubin Li, Chunlin Li, Lili Jiang
Living a happy and meaningful life is an eternal topic in positive psychology, which is crucial for individuals’ physical and mental health as well as social functioning. Well-being can be subdivided into pleasure attainment related hedonic well-being or emotional well-being, and self-actualization related eudaimonic well-being or psychological well-being plus social well-being. Previous studies have
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Transcranial magnetic stimulation and transcranial direct current stimulation affect explicit but not implicit emotion regulation: a meta-analysis Behav. Brain Funct. (IF 5.1) Pub Date : 2023-09-19 Xiufu Qiu, Zhenhong He, Xueying Cao, Dandan Zhang
Emotion regulation (ER) refers to the process through which people influence the occurrence, experience, and expression of emotions. It can be established in an explicit (voluntary) or implicit (automatic) way, both of which are essential for mental and physical well-being. Recent evidence has highlighted the potential of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation
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Ocular and neural genes jointly regulate the visuospatial working memory in ADHD children Behav. Brain Funct. (IF 5.1) Pub Date : 2023-09-01 Yilu Zhao, Yuanxin Zhong, Wei Chen, Suhua Chang, Qingjiu Cao, Yufeng Wang, Li Yang
Working memory (WM) deficits have frequently been linked to attention deficit hyperactivity disorder (ADHD). Despite previous studies suggested its high heritability, its genetic basis, especially in ADHD, remains unclear. The current study aimed to comprehensively explore the genetic basis of visual-spatial working memory (VSWM) in ADHD using wide-ranging genetic analyses. The current study recruited
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Enhancement of dynamic visual acuity using transcranial alternating current stimulation with gamma burst entrained on alpha wave troughs Behav. Brain Funct. (IF 5.1) Pub Date : 2023-08-24 Jimin Park, Sangjun Lee, Dasom Choi, Chang-Hwan Im
Cross-frequency phase-amplitude coupling (PAC) of cortical oscillations is observed within and across cortical regions during higher-order cognitive processes. Particularly, the PAC of alpha and gamma waves in the occipital cortex is closely associated with visual perception. In theory, gamma oscillation is a neuronal representation of visual stimuli, which drives the duty cycle of visual perception
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The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study Behav. Brain Funct. (IF 5.1) Pub Date : 2023-07-15 Yidi Chen, Jinjin Ma, Huanya Zhu, Huini Peng, Yiqun Gan
Stressful events and meaning-making toward them play an important role in adolescents’ life and growth. However, ignoring positive stressful events leads to negativity bias; further, the neural mechanisms of meaning-making are unclear. We aimed to verify the mediating role of meaning-making in stressful events and stress-related growth and the function of the default mode network (DMN) during meaning-making
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice Behav. Brain Funct. (IF 5.1) Pub Date : 2023-06-15 Yang Yun, Xuejiao Wang, Jingyi Xu, Jingyu Chen, Xueru Wang, Pingting Yang, Ling Qin
Neuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE). However, there are no dedicated treatments available in clinics to alleviate neuroinflammation in NPSLE. It has been proposed that stimulating basal forebrain (BF) cholinergic neurons may provide potent anti-inflammatory effects in several inflammatory diseases, but
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Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming Behav. Brain Funct. (IF 5.1) Pub Date : 2023-06-01 Jingjing Zhao, Qing Yang, Chen Cheng, Zhengjun Wang
KIAA0319, a well-studied candidate gene, has been shown to be associated with reading ability and developmental dyslexia. In the present study, we investigated whether KIAA0319 affects reading ability by interacting with the parental education level and whether rapid automatized naming (RAN), phonological awareness and morphological awareness mediate the relationship between KIAA0319 and reading ability
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Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice Behav. Brain Funct. (IF 5.1) Pub Date : 2023-05-25 Bakhtiarzadeh Fatemeh, Shahpasand Koorosh, Shojaei Amir, Fathollahi Yaghoub, Mirnajafi-Zadeh Javad
Alzheimer's disease is accompanied by an abnormal high accumulation of cis-P tau. However, the long-term changes in behavior following tau accumulation remains under debate. The present study investigated the long-term effects of tauopathy on learning and memory, synaptic plasticity, and hippocampal cell numbers. Cis-P tau was microinjected into the dorsal hippocampus to generate Alzheimer’s like-disease
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Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum Behav. Brain Funct. (IF 5.1) Pub Date : 2023-05-24 Macarena González-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodríguez de Fonseca, María Pascual, Marta Rodríguez-Arias
The lipid oleoylethanolamide (OEA) has been shown to affect reward-related behavior. However, there is limited experimental evidence about the specific neurotransmission systems OEA may be affecting to exert this modulatory effect. The aim of this study was to evaluate the effects of OEA on the rewarding properties of cocaine and relapse-related gene expression in the striatum and hippocampus. For
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Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice Behav. Brain Funct. (IF 5.1) Pub Date : 2023-04-13 Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li, Weizu Li
Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD). However, the specific mechanism of NLRP1 inflammasome in the pathogenesis of AD is still unclear. It has been reported that autophagy dysfunction can aggravate the pathological
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Distinct reinforcement learning profiles distinguish between language and attentional neurodevelopmental disorders Behav. Brain Funct. (IF 5.1) Pub Date : 2023-03-21 Noyli Nissan, Uri Hertz, Nitzan Shahar, Yafit Gabay
Theoretical models posit abnormalities in cortico-striatal pathways in two of the most common neurodevelopmental disorders (Developmental dyslexia, DD, and Attention deficit hyperactive disorder, ADHD), but it is still unclear what distinct cortico-striatal dysfunction might distinguish language disorders from others that exhibit very different symptomatology. Although impairments in tasks that depend
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Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load Behav. Brain Funct. (IF 5.1) Pub Date : 2023-03-20 Tamas Oroszi, Eva Geerts, Reuben Rajadhyaksha, Csaba Nyakas, Marieke J. G. van Heuvelen, Eddy A. van der Zee
Alzheimer’s disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown. Five months old male J20 mice (n = 26) and their wild type (WT) littermates
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Previous experience with delays affects delay discounting in animal model of ADHD Behav. Brain Funct. (IF 5.1) Pub Date : 2023-02-13 Espen Sjoberg, H. M. Ottåsen, R. G. Wilner, E. B. Johansen
ADHD is a disorder where a common symptom is impulsive behaviour, a broad term associated with making sub-optimal choices. One frequently used method to investigate impulsive behaviour is delay discounting, which involves choosing between a small, immediate reinforcer and a delayed, larger one. Choosing the small immediate reinforcer is by itself, however, not sufficient for terming the choice impulsive
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Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE) Behav. Brain Funct. (IF 5.1) Pub Date : 2023-02-10 Yang Yun, Xuejiao Wang, Jingyi Xu, Chenye Jin, Jingyu Chen, Xueru Wang, Jianing Wang, Ling Qin, Pingting Yang
The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication of SLE, we investigated the neuropsychiatric symptoms in the PIL mouse model to evaluate its suitability for NPSLE
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Increased basolateral amygdala metabolic activity during flavor familiarization: an experimental study Behav. Brain Funct. (IF 5.1) Pub Date : 2023-02-03 Sergio Menchén-Márquez, María Banqueri, Beatriz Gómez-Chacón, Jorge L. Arias, Milagros Gallo
Novel flavors elicit a cautious neophobic response which is attenuated as the flavor becomes familiar and safe. The attenuation of neophobia reveals the formation of a safe memory. Previous lesion studies in rats have reported that basolateral amygdala integrity is required for taste neophobia, but not neophobia to flavor, i.e., taste linked to an odorous component. Accordingly, immunohistochemical
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Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals Behav. Brain Funct. (IF 5.1) Pub Date : 2023-01-16 Shafia, Sakineh, Nikkhah, Farkhonde, Akhoundzadeh, Kobra
Despite significant differences between men and women in the symptoms of PTSD and the response to therapeutic interventions, most PTSD studies have been done on male subjects. Continuing our previous study in male rats, this study aimed at better understanding the effect of a combination therapy of exercise with fluoxetine on female PTSD rats. The results were then compared with our past findings in
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Expectation modulates the preferential processing of task-irrelevant fear in the attentional blink: evidence from event-related potentials Behav. Brain Funct. (IF 5.1) Pub Date : 2022-12-14 Sun, Meng, Shang, Chenyang, Jia, Xi, Liu, Fang, Cui, Lixia, Wei, Ping, Zhang, Qin
Reporting the second of the two targets is impaired when it occurs 200–500 ms after the first, the phenomenon in the study of consciousness is the attentional blink (AB). In the AB task, both the emotional salience and the expectation of the second target increase the likelihood of that target being consciously reported. Yet, little is known about how expectations modulate the prioritized processing
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Exposure to violence is associated with decreased neural connectivity in emotion regulation and cognitive control, but not working memory, networks after accounting for socioeconomic status: a preliminary study Behav. Brain Funct. (IF 5.1) Pub Date : 2022-12-12 Mattheiss, Samantha R., Levinson, Hillary, Rosenberg-Lee, Miriam, Graves, William W.
Previous research has demonstrated behavioral and neural differences associated with experiencing adversity. However, adversity is unlikely to be a monolithic construct, and we expect that examining effects of more specific components such as exposure to violence in the home community will yield more concretely interpretable results. Here we account for effects of low socioeconomic status (SES) to
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A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions Behav. Brain Funct. (IF 5.1) Pub Date : 2022-12-01 Nudel, Ron, Zetterberg, Richard, Hemager, Nicoline, Christiani, Camilla A. J., Ohland, Jessica, Burton, Birgitte K., Greve, Aja N., Spang, Katrine S., Ellersgaard, Ditte, Gantriis, Ditte L., Bybjerg-Grauholm, Jonas, Plessen, Kerstin J., Jepsen, Jens Richardt M., Thorup, Anne A. E., Werge, Thomas, Mors, Ole, Nordentoft, Merete
Many psychiatric and neurodevelopmental disorders are known to be heritable, but studies trying to elucidate the genetic architecture of such traits often lag behind studies of somatic traits and diseases. The reasons as to why relatively few genome-wide significant associations have been reported for such traits have to do with the sample sizes needed for the detection of small effects, the difficulty
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Children’s inhibition skills are associated with their P3a latency—results from an exploratory study Behav. Brain Funct. (IF 5.1) Pub Date : 2022-12-01 Linnavalli, Tanja, Lahti, Outi, Törmänen, Minna, Tervaniemi, Mari, Cowley, Benjamin Ultan
The P3a response is thought to reflect involuntary orienting to an unexpected stimulus and has been connected with set-shifting and inhibition in some studies. In our exploratory study, we investigated if the amplitude and the latency of the P3a response were associated with the performance in a modified flanker task measuring inhibition and set-shifting in 10-year-old children (N = 42). Children participated
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The Area Prostriata may play a role in technical reasoning Behav. Brain Funct. (IF 5.1) Pub Date : 2022-11-25 Federico, Giovanni, Cavaliere, Carlo, Reynaud, Emanuelle, Salvatore, Marco, Brandimonte, Maria Antonella, Osiurak, François
Most recent research indicated how technical reasoning (TR), namely, a specific form of causal reasoning aimed at understanding the physical world, may support the development of tools and technologies of increasing complexity. We have recently identified the Area PF of the left inferior parietal lobe (PF) as a critical structural correlate of TR, as assessed by using two ad-hoc psycho-technical tests
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Relations between family cohesion and adolescent-parent’s neural synchrony in response to emotional stimulations Behav. Brain Funct. (IF 5.1) Pub Date : 2022-09-27 Deng, Xinmei, Lin, Mingping, Zhang, Lin, Li, Xiaoqing, Gao, Qiufeng
The interaction between parent and adolescent is more challenging than in other age periods. Family cohesion seriously impacts parent-adolescent emotional interactions. However, the underlying neural mechanism has not been fully examined. This study examined the differences in the neural synchrony in response to emotional film clips between high and low family cohesion adolescent-parent dyads by using
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Enhancing allocation of visual attention with emotional cues presented in two sensory modalities Behav. Brain Funct. (IF 5.1) Pub Date : 2022-09-22 Zimmer, Ulrike, Wendt, Mike, Pacharra, Marlene
Responses to a visual target stimulus in an exogenous spatial cueing paradigm are usually faster if cue and target occur in the same rather than in different locations (i.e., valid vs. invalid), although perceptual conditions for cue and target processing are otherwise equivalent. This cueing validity effect can be increased by adding emotional (task-unrelated) content to the cue. In contrast, adding
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Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis Behav. Brain Funct. (IF 5.1) Pub Date : 2022-09-13 Pankey, Brianna S., Riedel, Michael C., Cowan, Isis, Bartley, Jessica E., Pintos Lobo, Rosario, Hill-Bowen, Lauren D., Salo, Taylor, Musser, Erica D., Sutherland, Matthew T., Laird, Angela R.
Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore
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Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model Behav. Brain Funct. (IF 5.1) Pub Date : 2022-08-06 Balbo, Ilaria, Montarolo, Francesca, Genovese, Federica, Tempia, Filippo, Hoxha, Eriola
Spinocerebellar ataxia 38 (SCA38) is a rare autosomal neurological disorder characterized by ataxia and cerebellar atrophy. SCA38 is caused by mutations of ELOVL5 gene. ELOVL5 gene encodes a protein, which elongates long chain polyunsaturated fatty acids (PUFAs). Knockout mice lacking Elovl5 recapitulate SCA38 symptoms, including motor coordination impairment and disruption of cerebellar architecture
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Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment Behav. Brain Funct. (IF 5.1) Pub Date : 2022-05-19 Delprato, Anna, Xiao, Emily, Manoj, Devika
Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken
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The shifting role of the cerebellum in executive, emotional and social processing across the lifespan Behav. Brain Funct. (IF 5.1) Pub Date : 2022-04-28 Beuriat, Pierre-Aurélien, Cristofori, Irene, Gordon, Barry, Grafman, Jordan
The cerebellum’s anatomical and functional organization and network interactions between the cerebellum and the cerebral cortex and subcortical structures are dynamic across the lifespan. Executive, emotional and social (EES) functions have likewise evolved during human development from contributing to primitive behaviors during infancy and childhood to being able to modulate complex actions in adults
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Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner Behav. Brain Funct. (IF 5.1) Pub Date : 2022-02-25 Pusceddu, Matteo M., Hernandez-Baixauli, Julia, Puiggrós, Francesc, Arola, Lluis, Caimari, Antoni, Del Bas, Josep M., Baselga, Laura
Several findings suggest neuroinflammation as a contributing factor for the onset of psychiatric disorders such as Alzheimer’s disease, depression, and anxiety. There is increasing evidence pointing out that the Mediterranean diet influences brain and behavior. Mediterranean herbs and spices have been shown to be within those components of the Mediterranean diet involved in cognitive enhancement. Thus
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Possible involvement of l-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice Behav. Brain Funct. (IF 5.1) Pub Date : 2022-02-14 Amini-Khoei, Hossein, Nasiri Boroujeni, Shakiba, Maghsoudi, Forough, Rahimi-Madiseh, Mohammad, Bijad, Elham, Moradi, Mohammadtaghi, Lorigooini, Zahra
Depression is one of the most common mental illnesses worldwide. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to possess pharmacological effects on neurological diseases. The present study aimed to investigate the possible role of the NO pathway in Auraptene antidepressant effects in male mice. Behavioral tests were used to assess
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The interplay between oxidative stress and autophagy: focus on the development of neurological diseases Behav. Brain Funct. (IF 5.1) Pub Date : 2022-01-29 Talebi, Marjan, Mohammadi Vadoud, Seyyed Ali, Haratian, Alireza, Talebi, Mohsen, Farkhondeh, Tahereh, Pourbagher-Shahri, Ali Mohammad, Samarghandian, Saeed
Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter. Mount-up shreds of evidence support that both autophagy and reactive oxygen species (ROS) are involved in the commencement and progression of neurological diseases. Remarkably, oxidative stress prompted by an increase of ROS threatens
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Sleep EEG characteristics associated with total sleep time misperception in young adults: an exploratory study Behav. Brain Funct. (IF 5.1) Pub Date : 2022-01-24 Xu, Biyun, Cai, Qinghao, Mai, Runru, Liang, Hailong, Huang, Jiayu, Yang, Zhimin
Power spectral analysis (PSA) is one of the most commonly-used EEG markers of cortical hyperarousal, and can help to understand subjective–objective sleep discrepancy (SOD). Age is associated with decreased sleep EEG activity; however, the PSA of young adults is currently limited. Thus, this study aimed to examine the correlation of spectral EEG power with total sleep time (TST) misperception in young
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Algebra dissociates from arithmetic in the brain semantic network Behav. Brain Funct. (IF 5.1) Pub Date : 2022-01-07 Cheng, Dazhi, Li, Mengyi, Cui, Jiaxin, Wang, Li, Wang, Naiyi, Ouyang, Liangyuan, Wang, Xiaozhuang, Bai, Xuejun, Zhou, Xinlin
Mathematical expressions mainly include arithmetic (such as 8 − (1 + 3)) and algebra (such as a − (b + c)). Previous studies have shown that both algebraic processing and arithmetic involved the bilateral parietal brain regions. Although previous studies have revealed that algebra was dissociated from arithmetic, the neural bases of the dissociation between algebraic processing and arithmetic is still
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NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice Behav. Brain Funct. (IF 5.1) Pub Date : 2021-12-17 Sun, Dan, Gao, Guofang, Zhong, Bihua, Zhang, Han, Ding, Shixin, Sun, Zhenghao, Zhang, Yaodong, Li, Weizu
Brain aging is an important risk factor in many human diseases, such as Alzheimer’s disease (AD). The production of excess reactive oxygen species (ROS) mediated by nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) and the maturation of inflammatory cytokines caused by activation of the NOD-like receptor protein 1 (NLRP1) inflammasome play central roles in promoting brain aging. However
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Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats Behav. Brain Funct. (IF 5.1) Pub Date : 2021-11-05 Forbes-Lorman, R. M.
Developing mammals are exposed to progesterone through several sources; however, the role of progesterone in early development is not well understood. Males express more progestin receptors (PRs) than females within several brain regions during early postnatal life, suggesting that PRs may be important for the organization of the sex differences in the brain and behavior. Indeed, previous studies showed
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Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats Behav. Brain Funct. (IF 5.1) Pub Date : 2021-11-01 Safari, Samaneh, Ahmadi, Nesa, Mohammadkhani, Reihaneh, Ghahremani, Reza, Khajvand-Abedeni, Maryam, Shahidi, Siamak, Komaki, Alireza, Salehi, Iraj, Karimi, Seyed Asaad
Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal
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The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology Behav. Brain Funct. (IF 5.1) Pub Date : 2021-07-07 Vladimir N. Nikolenko, Negoriya A. Rizaeva, Narasimha M. Beeraka, Marine V. Oganesyan, Valentina A. Kudryashova, Alexandra A. Dubovets, Irina D. Borminskaya, Kirill V. Bulygin, Mikhail Y. Sinelnikov, Gjumrakch Aliev
The claustrum is a structure involved in formation of several cortical and subcortical neural microcircuits which may be involved in such functions as conscious sensations and rewarding behavior. The claustrum is regarded as a multi-modal information processing network. Pathology of the claustrum is seen in certain neurological disorders. To date, there are not enough comprehensive studies that contain
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Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis Behav. Brain Funct. (IF 5.1) Pub Date : 2021-06-22 Enrico Patrono, Jan Svoboda, Aleš Stuchlík
Schizophrenia research arose in the twentieth century and is currently rapidly developing, focusing on many parallel research pathways and evaluating various concepts of disease etiology. Today, we have relatively good knowledge about the generation of positive and negative symptoms in patients with schizophrenia. However, the neural basis and pathophysiology of schizophrenia, especially cognitive
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Molecular and cellular pathways contributing to brain aging Behav. Brain Funct. (IF 5.1) Pub Date : 2021-06-12 Aliabbas Zia, Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Saeed Samarghandian
Aging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regard, brain aging is defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, neuroinflammation, and oxidatively
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The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study Behav. Brain Funct. (IF 5.1) Pub Date : 2021-05-29 Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Masoumeh Askari, Alireza Amirabadizadeh, Jeffrey Brent, Bruno Megarbane, Omid Mehrpour
Tramadol is a widely used synthetic opioid. Substantial research has previously focused on the neurological effects of this drug, while the efficacy of various treatments to reduce the associated side effects has not been well studied. This study aimed to evaluate the protective effects of naloxone, diazepam, and quercetin on tramadol overdose-induced seizure and sedation level in male rats. The project
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Distinct behavioral traits and associated brain regions in mouse models for obsessive–compulsive disorder Behav. Brain Funct. (IF 5.1) Pub Date : 2021-05-18 Xiao Chen, Jihui Yue, Yuchong Luo, Lianyan Huang, Boxing Li, Shenglin Wen
Obsessive–compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to the behavioral heterogeneity, however, are unknown. We systematically examined the behavioral phenotypes of three OCD mouse models induced by pharmacological reagents [RU24969, 8-hydroxy-DPAT hydrobromide
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Linalool odor‐induced analgesia is triggered by TRPA1-independent pathway in mice Behav. Brain Funct. (IF 5.1) Pub Date : 2021-04-26 Hideki Kashiwadani, Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki
We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute
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Susceptibility to chronic immobilization stress‐induced depressive-like behaviour in middle‐aged female mice and accompanying changes in dopamine D1 and GABAA receptors in related brain regions Behav. Brain Funct. (IF 5.1) Pub Date : 2021-04-16 Guofen Cao, Gaili Meng, Li Zhu, Jie Zhu, Nan Dong, Xiaolan Zhou, Sumei Zhang, Yongai Zhang
Middle-aged females, especially perimenopausal females, are vulnerable to depression, but the potential mechanism remains unclear. Dopaminergic and GABAergic system dysfunction is involved in the pathophysiology of depression. In the current study, we used 2-month-old and 11-month-old C57BL/6 mice as young and middle-aged mice, respectively. Chronic immobilization stress (CIS) was used to induce depressive-like
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The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats Behav. Brain Funct. (IF 5.1) Pub Date : 2021-02-21 Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarihi
The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including mGlu8 receptors, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study
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Rapid acquisition of novel written word-forms: ERP evidence Behav. Brain Funct. (IF 5.1) Pub Date : 2020-12-02 Beatriz Bermúdez-Margaretto, Yury Shtyrov, David Beltrán, Fernando Cuetos, Alberto Domínguez
Novel word acquisition is generally believed to be a rapid process, essential for ensuring a flexible and efficient communication system; at least in spoken language, learners are able to construct memory traces for new linguistic stimuli after just a few exposures. However, such rapid word learning has not been systematically found in visual domain, with different confounding factors obscuring the
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Astaxanthin protects cognitive function of vascular dementia Behav. Brain Funct. (IF 5.1) Pub Date : 2020-11-18 Ningwei Zhu, Xiao Liang, Ming Zhang, Xiaolan Yin, Hui Yang, Yajun Zhi, Guizhen Ying, Jialing Zou, Lei Chen, Xiaokun Yao, Hongwei Li
The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate
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Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats Behav. Brain Funct. (IF 5.1) Pub Date : 2020-11-06 Dina M. Monir, Motamed E. Mahmoud, Omyma G. Ahmed, Ibrahim F. Rehan, Amany Abdelrahman
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism. This study aimed to evaluate
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Behavioral and Brain Functions at 15 Behav. Brain Funct. (IF 5.1) Pub Date : 2020-10-23 Wim E. Crusio
Fifteen years ago, on April 22, 2005, the first articles published by the new journal Behavioral and Brain Functions (BBF) were made available online [1]. The journal was the fruit of the enthusiastic efforts of Terje Sagvolden, who would be editor-in-chief until his untimely death in 2011 [2]. To the best of my knowledge, BBF was the first behavioral neuroscience journal that was online-only and open-access