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Determinants and functional impacts of diaphragmatic involvement in patients with inclusion body myositis Muscle Nerve (IF 2.505) Pub Date : 2021-01-12 Marie‐Hélène Lelièvre; Marie Hudson; Stephan A. Botez; Bruno‐Pierre Dubé
We evaluated the functional consequences of diaphragm involvement in patients with inclusion body myositis (IBM).
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Melatonin may slow disease progression in amyotrophic lateral sclerosis: Findings from the Pooled Resource Open‐Access ALS Clinic Trials database Muscle Nerve (IF 2.505) Pub Date : 2021-01-11 Elizabeth M. Bald; Christopher S. Nance; Jordan L. Schultz
We utilized the Pooled Resource Open‐Access Clinical Trials (PRO‐ACT) database to investigate whether melatonin use among patients with amyotrophic lateral sclerosis (ALS) was associated with slower disease progression and prolonged survival.
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Quantitative laryngeal electromyography parameters may correlate with improved outcomes following botulinum toxin injection for spasmodic dysphonia Muscle Nerve (IF 2.505) Pub Date : 2020-12-31 Christopher D. Dwyer; Andrée‐Anne Leclerc; Sanjeev D. Nandedkar; VyVy N. Young; Clark A. Rosen
Despite use of qualitative laryngeal electromyography (LEMG) guided botulinum toxin A (BoNT‐A) injection for treatment of adductor spasmodic dysphonia (AdSD), unsatisfactory injections and complete “misses” remain problematic. We aimed to determine if the quantitative LEMG measure of number of small segments (NSS) correlates with voice outcomes following (BoNT‐A injection for AdSD.
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Nodal conduction block: A unifying concept Muscle Nerve (IF 2.505) Pub Date : 2020-11-12 Shin J. Oh
A newly introduced term, “axonal conduction block,” brought a confusion in the electrodiagnostic diagnosis of Guillain‐Barrè syndrome (GBS). I am proposing the term “nodal conduction block” for “axonal conduction block.” This unifying concept of nodal conduction block will accommodate both the traditional concept of demyelination as well as the new concept of nodopathy in the “axonal form of GBS,”
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Walking activity in a large cohort of boys with Duchenne muscular dystrophy Muscle Nerve (IF 2.505) Pub Date : 2020-11-14 Donovan J. Lott; Tanja Taivassalo; Claudia R. Senesac; Rebecca J. Willcocks; Ann M. Harrington; Kirsten Zilke; Hilary Cunkle; Catherine Powers; Erika L. Finanger; William D. Rooney; Gihan I. Tennekoon; Krista Vandenborne
In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD).
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Early and consistent pattern of proximal weakness in GNE myopathy Muscle Nerve (IF 2.505) Pub Date : 2020-11-16 Satish V. Khadilkar; Amit D. Chaudhari; Madhu B. Singla; Rashna S. Dastur; Pradnya S. Gaitonde; Ashish G. Bhutada; Madhuri R. Hegde
GNE myopathy is widely regarded as a distal myopathy. Involvement of proximal musculature in this condition has not been systematically studied.
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Fasciculation frequency at the biceps brachii and brachialis muscles is associated with amyotrophic lateral sclerosis disease burden and activity Muscle Nerve (IF 2.505) Pub Date : 2020-11-20 Reuven Avidan; Yaara Fainmesser; Vivian E. Drory; Vera Bril; Alon Abraham
Fasciculations are most commonly seen in the biceps brachii muscle in amyotrophic lateral sclerosis (ALS). In this study we have explored the association between fasciculation frequency in a single location—biceps brachii and brachialis muscles (BB), and disease burden and activity.
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The Duke myasthenia gravis clinic registry: I. Description and demographics Muscle Nerve (IF 2.505) Pub Date : 2020-11-17 Donald B. Sanders; Shruti M. Raja; Jeffrey T. Guptill; Lisa D. Hobson‐Webb; Vern C. Juel; Janice M. Massey
The Duke Myasthenia Gravis (MG) Clinic Registry is a disease‐specific database containing physician‐derived data from patients seen in the Duke MG Clinic since 1980.
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Motion sensor‐acquired reachable workspace correlates with patient‐reported upper extremity activities of daily living (ADL) function in facioscapulohumeral dystrophy Muscle Nerve (IF 2.505) Pub Date : 2020-11-20 Maya N. Hatch; Gregorij Kurillo; Vicky Chan; Jay J. Han
This study examines the correlation, and clinical meaningfulness, between reachable workspace outcome and reported activities of daily living (ADL) function of individuals with facioscapulohumeral dystrophy (FSHD).
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Obligatory role of Schwann cell‐specific erythropoietin receptors in erythropoietin‐induced functional recovery and neurogenic muscle atrophy after nerve injury Muscle Nerve (IF 2.505) Pub Date : 2020-11-18 M A Hassan Talukder; Jung Il Lee; John P. Hegarty; Anagha A. Gurjar; Mary O'Brien; Zara Karuman; Grant D. Wandling; Prem Kumar Govindappa; John C. Elfar
Erythropoietin (EPO) promotes myelination and functional recovery in rodent peripheral nerve injury (PNI). While EPO receptors (EpoR) are present in Schwann cells, the role of EpoR in PNI recovery is unknown because of the lack of EpoR antagonists or Schwann cell‐specific EpoR knockout animals.
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Suicide among Veterans with Amyotrophic Lateral Sclerosis Muscle Nerve (IF 2.505) Pub Date : 2021-01-20 Emily M. Lund; Trisha A. Hostetter; Jeri E. Forster; Claire A. Hoffmire; Kelly A. Stearns‐Yoder; Lisa A. Brenner; Maryam Tahmasbi Sohi
The purpose of this study was to estimate the risk of death by suicide for those with amyotrophic lateral sclerosis (ALS) seeking care within the Veteran Health Administration (VHA).
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Doctor – Should I get the COVID‐19 vaccine? Infection and Immunization in Individuals with Neuromuscular Disorders Muscle Nerve (IF 2.505) Pub Date : 2021-01-20 Sasha A živkoviĆ; Gregory Gruener; Pushpa Narayanaswami;
The clinical course of neuromuscular disorders (NMDs) can be affected by infections, both in immunocompetent individuals, and in those with reduced immunocompetence due to immunosuppressive/immunomodulating therapies. Infections and immunizations may also trigger NMDs. There is a potential for reduced efficacy of immunizations in patients with reduced immunocompetence. The recent vaccination program
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Differentiating Moebius syndrome and other congenital facial weakness disorders with electrodiagnostic studies Muscle Nerve (IF 2.505) Pub Date : 2021-01-02 Tanya Lehky; Reversa Joseph; Camilo Toro; Tianxia Wu; Carol Van Ryzin; Andrea Gropman; Flavia M. Facio; Bryn D. Webb; Ethylin W. Jabs; Brenda S. Barry; Elizabeth C. Engle; Francis S. Collins; Irini Manoli;
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Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1 Muscle Nerve (IF 2.505) Pub Date : 2021-01-18 Ellen van der Plas; Laurie Gutmann; Dan Thedens; Richard K. Shields; Kathleen Langbehn; Zhihui Guo; Milan Sonka; Peggy Nopoulos
Quantitative muscle MRI as a sensitive marker of early muscle pathology and disease progression in adult‐onset myotonic dystrophy type 1
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Neuromuscular amyloidosis: Unmasking the master of disguise Muscle Nerve (IF 2.505) Pub Date : 2021-01-17 Marcus V. Pinto; P. James B. Dyck; Teerin Liewluck
Amyloidosis refers to an etiologically heterogeneous group of protein misfolding diseases, pathologically characterized by extracellular amyloid fibrils producing congophillic amorphous deposits in organs and tissues, which may lead to severe organ dysfunction and mortality. Clinical presentations vary and are often nonspecific, depending on what organs or tissues are affected. In systemic amyloidosis
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Ultrasound guidance may have advantages over landmark‐based guidance for some nerve conduction studies Muscle Nerve (IF 2.505) Pub Date : 2021-01-05 Kuo‐Chang Wei; Yi‐Hsiang Chiu; Chueh‐Hung Wu; Huey‐Wen Liang; Tyng‐Guey Wang
Precise placement of stimulating and recording electrodes is vital when performing nerve conduction studies (NCSs). In this study, we aimed to determine whether ultrasonography (US) was more precise in localizing the superficial radial nerve (SRN), dorsal ulnar cutaneous nerve (DUCN), ulnar nerve (UN) crossing the cubital tunnel, and radial nerve (RN) crossing the spiral groove (SG) compared to conventional
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Is it time to revisit the Boston Carpal Tunnel Questionnaire? New insights from a Rasch model analysis Muscle Nerve (IF 2.505) Pub Date : 2021-01-17 Christina Jerosch‐Herold; Jeremy DP Bland; Mike Horton
The Boston Carpal Tunnel Questionnaire (BCTQ) is a patient‐reported outcome measure (PROM) used to measure symptom severity and function in carpal tunnel syndrome (CTS). Despite its wide usage, investigation of its measurement properties using modern psychometric methodologies is limited.
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Changes in motor nerve excitability in acute phase Guillain‐Barré syndrome Muscle Nerve (IF 2.505) Pub Date : 2021-01-15 Judith Drenthen; Badrul Islam; Zhahirul Islam; Quazi D. Mohammad; Ellen M. Maathuis; Gerhard H. Visser; Pieter A. van Doorn; Joleen H. Blok; Hubert P. Endtz; Bart C. Jacobs
The most common subtypes of Guillain‐Barré syndrome (GBS) are acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). In the first days after the onset of weakness, standard nerve conduction studies (NCS) may not distinguish GBS subtypes. Reduced nerve excitability may be an early symptom of nerve dysfunction, which can be determined with the compound muscle
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Chronic idiopathic axonal polyneuropathy: Electrophysiological progression and human leukocyte antigen associations Muscle Nerve (IF 2.505) Pub Date : 2021-01-13 Panagiotis Zis; Ptolemaios G. Sarrigiannis; Artemios Artemiadis; Vasiliki Skarlatou; Marios Hadjivassiliou
We aimed to describe the electrophysiological progression rate of chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role of human leukocyte antigen (HLA) genetic susceptibility in its development.
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Effect of exercise training on functional capacity and body composition in myotonic dystrophy type 2 patients Muscle Nerve (IF 2.505) Pub Date : 2020-12-29 Eleni Kontou; Constantinos Papadopoulos; Giorgos Papadimas; Argyris Toubekis; Gregory Bogdanis; Sophia Xirou; Evangelia Kararizou; Spyridon Methenitis; Gerasimos Terzis
Myotonic dystrophy type 2 (DM2) is a neuromuscular disorder characterized by myotonia and muscle weakness, with no medical treatment to prevent a decline in decline. It is unknown whether exercise training is effective in DM2. The aim of this study was to investigate the effect of exercise training on functional capacity and body composition in these patients.
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Muscle fiber size in healthy children and adults in relation to sex and fiber types Muscle Nerve (IF 2.505) Pub Date : 2020-12-21 Mona E. Esbjörnsson; Monica S. Dahlström; Jan W. Gierup; Eva Ch. Jansson
In adult males, cross‐sectional area (CSA) for type II muscle fibers is generally larger than for type I fibers. In this cross‐sectional study the aim was to compare sex‐related CSAs of various muscle fiber types during childhood‐to‐adulthood transition.
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Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice Muscle Nerve (IF 2.505) Pub Date : 2021-01-01 Noriaki Kawanishi; Shuichi Machida
Skeletal muscle inflammation and oxidative stress are associated with aging‐related loss of muscle mass and may be attributable to alterations in the number and types of leukocytes in skeletal muscle. Here, we tested the hypothesis that aging changes the number and composition of leukocyte subsets in skeletal muscle tissue.
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Neuromuscular ultrasound competency assessment: Consensus‐based survey Muscle Nerve (IF 2.505) Pub Date : 2020-12-31 Eman A. Tawfik; Michael S. Cartwright; Alexander Grimm; Andrea J. Boon; Antonios Kerasnoudis; David C. Preston; Einar Wilder‐Smith; Hubertus Axer; Lisa D. Hobson‐Webb; Nens van Alfen; Nicholas Crump; Nortina Shahrizaila; Peter Inkpen; Ross Mandeville; Sarada Sakamuri; Steven J Shook; Susan Shin; Francis O. Walker
Neuromuscular ultrasound is a rapidly evolving specialty with direct application for patient care. Competency assessment is an essential standard needed to ensure quality for practitioners, particularly for those newly acquiring skills with the technique. Our aim was to survey experts' opinions regarding physician competency assessment of neuromuscular ultrasound and to identify minimal competency
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COL6A1 related muscular dystrophy in Landseer dogs: A canine model for Ullrich congenital muscular dystrophy Muscle Nerve (IF 2.505) Pub Date : 2020-12-31 Jan Brands; Frank Steffen; Jochen Spennes; Tosso Leeb; Thomas Bilzer
Collagen VI related myopathies are congenital diseases of variable phenotype. The severe phenotype is referred to as Ullrich congenital muscular dystrophy. In this study, we describe analoguos clinical signs and histopathological alterations in Landseer dogs.
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Risk factors for developing post‐thymectomy myasthenia gravis in patients with thymoma Muscle Nerve (IF 2.505) Pub Date : 2021-01-12 Ahwon Kim; Seok‐Jin Choi; Chang Hyun Kang; Seonkyung Lee; Hyoshin Son; Jin‐Ah Kim; Je‐Young Shin; Sung‐Min Kim; Yoon‐Ho Hong; Jung‐Joon Sung
Thymectomy is required for the treatment of thymoma‐associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post‐thymectomy MG. This study aimed to investigate the risk factors for post‐thymectomy MG in patients with thymoma.
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Anti‐cN1A antibodies do not correlate with specific clinical, electromyographic, or pathological findings in sporadic inclusion body myositis Muscle Nerve (IF 2.505) Pub Date : 2020-12-29 Pritikanta Paul; Teerin Liewluck; Floranne C Ernste; Jay Mandrekar; Margherita Milone
Anti‐cytosolic 5′‐nucleotidase 1A (cN1A) antibodies are commonly detected in patients with sporadic inclusion body myositis (sIBM). However, their pathogenic role has not been established. Moreover, efforts toward identifying sIBM distinct clinicopathologic characteristics associated with these antibodies have yielded conflicting results.
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The Complex Association Between Pain And Neuropathy Muscle Nerve (IF 2.505) Pub Date : 2021-01-12 Alon Abraham; Leif E. Lovblom; Vera Bril
Several studies of patients with polyneuropathy failed to show differences between patients with and without pain. In the current study, we aimed to explore the association between neuropathic symptoms, mainly pain, and polyneuropathy characteristics.
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Morphometric analysis of nerve fibers in neural leprosy Muscle Nerve (IF 2.505) Pub Date : 2020-12-21 Sérgio Luiz Gomes Antunes; Valéria Paula Sassoli Fazan; Márcia Rodrigues Jardim; Mário José dos Santos Pereira; Eduardo Alves Freire da Costa; Bernardo Oliveira Pascarelli; Mariana Andrea Vilasboas Hacker; Euzenir Nunes Sarno; Amilton Antunes Barreira
The present study assesses the contributions of axonal degeneration and demyelination in leprosy nerve damage. New clinical strategies can emerge from an in‐depth understanding of the pathogenesis of neural leprosy (NL).
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12‐Month progression of motor and functional outcomes in congenital myotonic dystrophy Muscle Nerve (IF 2.505) Pub Date : 2020-12-20 Kellen H. Quigg; Kiera N. Berggren; Melissa McIntyre; Kameron Bates; Francesca Salmin; Jacopo L. Casiraghi; Adele DʼAmico; Guja Astrea; Federica Ricci; Marnee J. McKay; Jennifer N. Baldwin; Joshua Burns; Craig Campbell; Valeria A. Sansone; Nicholas E. Johnson
We aim to describe 12‐mo functional and motor outcome performance in a cohort of participants with congenital myotonic dystrophy (CDM).
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Treatable, motor‐sensory, axonal neuropathies with C5b‐9 complement on endoneurial microvessels Muscle Nerve (IF 2.505) Pub Date : 2020-12-21 Bhavesh Trikamji; Alan Pestronk
Identification and treatment of immune‐mediated polyneuropathies may lead to improved strength and function. We studied the clinical and laboratory features, and treatment response, in patients with motor‐sensory axonal polyneuropathies who were found to have C5b‐9 complement staining on endoneurial microvessels.
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Neuromuscular ultrasound findings in carpal tunnel syndrome with symptoms mainly in the nondominant hand Muscle Nerve (IF 2.505) Pub Date : 2020-12-21 Pitcha Chompoopong; David C Preston
Carpal tunnel syndrome (CTS) may be associated with structural lesions or anatomical variations at the wrist, especially in patients whose symptoms are more severe in, or limited to, the nondominant hand. The aims of this study were to identify the type and frequency of structural abnormalities and anatomical variations, and to demonstrate the contribution of ultrasound in this subgroup of CTS patients
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Anti‐calcitonin gene–related peptide monoclonal antibodies for neuropathic pain in patients with migraine headache Muscle Nerve (IF 2.505) Pub Date : 2020-12-21 Seung Ah Kang; Raghav Govindarajan
There is increasing evidence that calcitonin gene–related peptide (CGRP) plays a role in the development of neuropathic pain, a common feature of peripheral neuropathy. Although clinical studies have shown that anti‐CGRP monoclonal antibodies are highly efficacious for migraine headache prophylaxis, their effects on nonheadache chronic pain conditions, including neuropathic pain, in humans are unknown
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Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review Muscle Nerve (IF 2.505) Pub Date : 2020-12-02 Lejla Alic; John F. Griffin; Aydin Eresen; Joe N. Kornegay; Jim X. Ji
There is a great demand for accurate non‐invasive measures to better define the natural history of disease progression or treatment outcome in Duchenne muscular dystrophy (DMD) and to facilitate the inclusion of a large range of participants in DMD clinical trials. This review aims to investigate which MRI sequences and analysis methods have been used and to identify future needs. Medline, Embase,
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Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial Muscle Nerve (IF 2.505) Pub Date : 2020-12-19 Michael D. Weiss; Eric A. Macklin; Courtney E. McIlduff; Steve Vucic; Brian J. Wainger; Matthew C. Kiernan; Stephen A. Goutman; Namita A. Goyal; Seward B. Rutkove; Shafeeq S. Ladha; I‐Hweii Amy Chen; Matthew B. Harms; Thomas H. Brannagan; David Lacomis; Sasha Zivkovic; Maxwell Ma; Leo H. Wang; Zachary Simmons; Michael H. Rivner; Jeremy M. Shefner; Merit E. Cudkowicz; Nazem Atassi;
To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double‐blind randomized controlled trial.
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Muscle Nerve (IF 2.505) Pub Date : 2020-12-30
Erratum for P. Seror et al. “Voluntary winging of the scapula: proposed diagnostic criteria”. Muscle and Nerve, November 2020; Volume 62. Issue 5. Pages 611–616. https://doi.org/10.1002/mus.27047 There was an error in the author list. MK Alexandra Roren, PhD, should read Alexandra Roren, PhD. We apologize for this error.
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Fasciculation analysis reveals a novel parameter that correlates with predicted survival in amyotrophic lateral sclerosis Muscle Nerve (IF 2.505) Pub Date : 2020-12-08 Kate Wannop; James Bashford; Aidan Wickham; Raquel Iniesta; Emmanuel Drakakis; Martyn Boutelle; Kerry Mills; Chris Shaw
Prognostic uncertainty in amyotrophic lateral sclerosis (ALS) confounds clinical management planning, patient counseling, and trial stratification. Fasciculations are an early clinical hallmark of disease and can be quantified noninvasively. Using an innovative analytical method, we correlated novel fasciculation parameters with a predictive survival model.
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Diagnostic usefulness of denervation edema in the multifidus muscles using 3‐Tesla magnetic resonance imaging in cervical radiculopathy Muscle Nerve (IF 2.505) Pub Date : 2020-12-13 Takeshi Yoshida; Shugo Suwazono; Takeshi Sueyoshi; Yuishin Izumi; Hiroyuki Nodera
Diagnosing cervical radiculopathy (CR) can be difficult because of symptomatic overlap with peripheral neuropathies. In this retrospective observational study, we aimed to determine whether short‐tau inversion recovery (STIR) magnetic resonance imaging (MRI) sequences are useful for detecting signs of denervation in the multifidus muscles in patients with CR.
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Reduced plasmablast frequency is associated with seronegative myasthenia gravis Muscle Nerve (IF 2.505) Pub Date : 2020-12-08 Jeffrey T. Guptill; Richard Barfield; Cliburn Chan; Melissa A. Russo; Doug Emmett; Shruti Raja; Janice M. Massey; Vern C. Juel; Lisa D. Hobson‐Webb; Karissa L. Gable; Natalia Gonzalez; Alex Hammett; James F. Howard; Manisha Chopra; Henry J. Kaminski; Zaeem A. Siddiqi; Mattingly Migdal; John S. Yi
The immunopathology of autoimmune seronegative myasthenia gravis (SN MG) is poorly understood. Our objective was to determine immune profiles associated with a diagnosis of SN MG.
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Phrenic nerve conduction study to diagnose unilateral diaphragmatic paralysis Muscle Nerve (IF 2.505) Pub Date : 2020-12-13 Vivien Reynaud; Hélène Prigent; Aurélien Mulliez; Marie‐Christine Durand; Frédéric Lofaso
Unilateral diaphragmatic paralysis (UDP) has major clinical and etiological implications and, therefore, is important to diagnose. Lung function tests and invasive transdiaphragmatic pressure (Pdi) measurements are widely used to this end but, contrary to phrenic nerve conduction study (NCS), they require volitional maneuvers and/or may be poorly tolerated by patients. The purpose of this study was
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Motor axonal neuropathy associated with GNE mutations Muscle Nerve (IF 2.505) Pub Date : 2020-10-23 Nicolae Grecu; Luisa Villa; Michele Cavalli; Antoine Ristaino; Ariane Choumert; Catherine Butori; Leonardo Salviati; Angela Puma; Sabrina Sacconi; Martin Krahn; Mathieu Cerino
Mutations in the GNE gene have been so far described as predominantly associated with distal lower‐limb myopathies. Recent reports describe mutations in this gene in patients with peripheral neuropathy and motor neuron disease.
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Temporal evolution of nerve conduction study abnormalities in anti‐myelin‐associated glycoprotein neuropathy Muscle Nerve (IF 2.505) Pub Date : 2020-12-08 Pierre R. Bourque; Josée Masson‐Roy; Jodi Warman‐Chardon; Rami Massie; Michel Melanson; John Brooks; Ari Breiner
A distal‐predominant demyelinating symmetric pattern is most frequent in patients with neuropathy associated with anti‐myelin‐associated glycoprotein (MAG) antibodies. The literature however lacks longitudinal data to describe whether this is consistent over time.
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Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy Muscle Nerve (IF 2.505) Pub Date : 2020-12-08 Donovan J. Lott; Tanja Taivassalo; Korey D. Cooke; Hyunjun Park; Zahra Moslemi; Abhinandan Batra; Sean C. Forbes; Barry J. Byrne; Glenn A. Walter; Krista Vandenborne
This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
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Finger drop sign as a new variant of acute motor axonal neuropathy Muscle Nerve (IF 2.505) Pub Date : 2020-11-20 Byeol‐A Yoon; Dong‐Ho Ha; Hwan Tae Park; Susumu Kusunoki; Motoi Kuwahara; Jong Hwa Lee; Jong Seok Bae; Jong Kuk Kim
We propose the finger drop sign as a new clinical variant of acute motor axonal neuropathy (AMAN) defined by immunological and radiological evidence. We identified eight consecutive patients who had AMAN. All of them developed prominent involvement of the finger extensors. We performed magnetic resonance imaging (MRI) of the extremity muscles and serological assays for antiganglioside antibodies and
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Relationship between ultrasonographic hand muscle thickness measurements and muscle strength following median or ulnar nerve reconstruction Muscle Nerve (IF 2.505) Pub Date : 2020-11-26 TO Misirlioglu; Deniz Palamar; Ozden Ozyemisci Taskiran; Rana Terlemez; Kenan Akgun
The aim of this study was to assess the relationship between ultrasonographic hand muscle thickness measurements and hand muscle strength in patients who underwent median or ulnar nerve reconstruction.
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Knowledge and perceptions of the COVID‐19 pandemic among patients with myasthenia gravis Muscle Nerve (IF 2.505) Pub Date : 2020-12-05 Yingkai Li; C. Douglas Emmett; Marjan Cobbaert; Donald B. Sanders; Vern C. Juel; Lisa D. Hobson‐Webb; Janice M. Massey; Karissa L. Gable; Shruti M. Raja; Natalia L. Gonzalez; Jeffrey T. Guptill
Patients with myasthenia gravis (MG) may be particularly vulnerable during the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic due to risk of worsening disease during infection, potential adverse impacts of coronavirus disease 2019 (COVID‐19) treatments on neuromuscular transmission, and a limited ability to fight off infection related to immunosuppressive treatments. Our goal
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Regenerative peripheral nerve interface free muscle graft mass and function Muscle Nerve (IF 2.505) Pub Date : 2020-12-08 Yaxi Hu; Daniel C. Ursu; Racquel A. Sohasky; Ian C. Sando; Shoshana L. W. Ambani; Zachary P. French; Elizabeth A. Mays; Andrej Nedic; Jana D. Moon; Theodore A. Kung; Paul S. Cederna; Stephen W. P. Kemp; Melanie G. Urbanchek
Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high‐fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal.
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Patient compliance with orthotic use‐ can we do better? An editorial for Zuccarino et al. “Satisfaction with Ankle Foot Orthoses in Individuals with Charcot–Marie‐Tooth” Muscle Nerve (IF 2.505) Pub Date : 2020-11-03 Akiko Hachisuka; Lindsay Hubenig; K. Ming Chan
See article on pages 40–45 in this issue.
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Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis Muscle Nerve (IF 2.505) Pub Date : 2020-10-16 Sabrina Paganoni; Suzanne Hendrix; Samuel P. Dickson; Newman Knowlton; Eric A. Macklin; James D. Berry; Michael A. Elliott; Samuel Maiser; Chafic Karam; James B. Caress; Margaret Ayo Owegi; Adam Quick; James Wymer; Stephen A. Goutman; Daragh Heitzman; Terry D. Heiman‐Patterson; Carlayne E. Jackson; Colin Quinn; Jeffrey D. Rothstein; Edward J. Kasarskis; Jonathan Katz; Liberty Jenkins; Shafeeq Ladha;
An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a long‐term survival analysis of participants in CENTAUR. In CENTAUR, adults with ALS were randomized 2:1 to PB‐TURSO or placebo. Participants completing the 6‐month
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Novel imaging techniques using 18F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy Muscle Nerve (IF 2.505) Pub Date : 2020-10-23 Kamal Shouman; Stephen M. Broski; Eli Muchtar; Courtney A. Pendleton; Geoffrey B. Johnson; Jennifer Tracy; Janean K. Engelstad; Robert J. Spinner; P. James B. Dyck
Multiple mononeuropathy is a rare presentation of primary (AL) amyloidosis and nerve biopsy is usually needed for diagnosis. Conventional imaging is useful to identify proximal nerve involvement but may be inadequate. We report a patient with multiple mononeuropathy whose presentation was suggestive of AL amyloid neuropathy and in whom repeated tissue biopsies were negative for amyloid (including two
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Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis Muscle Nerve (IF 2.505) Pub Date : 2020-10-29 John D. Lee; Saman Heshmat; Susan Heggie; Kathryn A. Thorpe; Pamela A. McCombe; Robert D. Henderson
The split‐hand concept has highlighted the preferential wasting of the thenar side of the hand in amyotrophic lateral sclerosis (ALS). Our objective is to re‐explore pinch grip strength to assess whether it has the potential to be a practical biomarker of ALS.
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Single‐institutional reference values for concentric needle jitter analysis using the extrapolated reference values procedure: Comparison to published reference values Muscle Nerve (IF 2.505) Pub Date : 2020-10-16 Ikjae Lee; Donald B. Sanders; Sanjeev D. Nandedkar; Mohamed Kazamel
The extrapolated reference values procedure (E‐Ref) was used to compare data from a single institution with the recently published reference value (RV) for concentric electrode jitter.
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Reference jitter values for the sternocleidomastoid muscle with concentric needle electrodes Muscle Nerve (IF 2.505) Pub Date : 2020-10-17 Ezgi Kula; Tulin Tanridag; Pinar Kahraman Koytak; Kayihan Uluc
The aim of this study was to establish reference jitter values for the voluntary activated sternocleidomastoid (SCM) muscle using a concentric needle electrode (CNE).
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Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis Muscle Nerve (IF 2.505) Pub Date : 2020-10-23 Gregory T. Carter; Ryan J. McLaughlin; Carrie Cuttler; Garrett J. Sauber; Douglas L. Weeks; Cecilia J. Hillard; Michael D. Weiss
The goals of this study were to determine whether serum concentrations of endocannabinoids (eCB) and related lipids predict disease status in patients with amyotrophic lateral sclerosis (ALS) relative to healthy controls, and whether concentrations correlate with disease duration and severity.
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Predicting myofiber cross‐sectional area and triglyceride content with electrical impedance myography: A study in db/db mice Muscle Nerve (IF 2.505) Pub Date : 2020-10-16 Sarbesh R. Pandeya; Janice A. Nagy; Daniela Riveros; Carson Semple; Rebecca S. Taylor; Marie Mortreux; Benjamin Sanchez; Kush Kapur; Seward B. Rutkove
Electrical impedance myography (EIM) provides insight into muscle composition and structure. We sought to evaluate its use in a mouse obesity model characterized by myofiber atrophy.
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COVID‐19‐associated myositis may be dermatomyositis Muscle Nerve (IF 2.505) Pub Date : 2020-10-23 Jantima Tanboon; Ichizo Nishino
See article on pages E10 in this issue.
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Reply Muscle Nerve (IF 2.505) Pub Date : 2020-10-23 Jonathan Perk; Yaacov Anziska; Roberta Seidman
See article on pages E9–E10 in this issue.
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Early experiences of nusinersen for the treatment of spinal muscular atrophy: Results from a large survey of patients and caregivers Muscle Nerve (IF 2.505) Pub Date : 2020-11-12 Er Chen; Stacy Dixon; Rupali Naik; Josh M. Noone; J. Daniel Buchenberger; Sarah M. Whitmire; Rosalina Mills; William Arnold
This study aimed to examine the early experience of nusinersen for spinal muscular atrophy (SMA) from the patient and caregiver perspective.
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Managing uncommon and unexpected findings during neuromuscular ultrasound Muscle Nerve (IF 2.505) Pub Date : 2020-12-15 Francis O. Walker; Michael S. Cartwright; Christopher H. Hunt
One barrier to widespread adoption of neuromuscular ultrasound by clinical neurophysiologists is concern over how to identify and manage non‐neuromuscular findings. This review addresses this concern by describing the sonographic appearance of a variety of commonly observed pathologies and anatomic variants in dermal, subcutaneous, bony, glandular, lymphatic, vascular, and other superficial tissues
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Proximal fibular nerve conduction studies to tibialis anterior: Optimal E2 (reference electrode) placement Muscle Nerve (IF 2.505) Pub Date : 2020-11-26 Timothy J. Day
Several E2 (reference electrode) positions are described for fibular (peroneal) nerve conduction studies to tibialis anterior (TA).
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Tongue and hypoglossal morphology after intralingual cholera toxin B–saporin injection Muscle Nerve (IF 2.505) Pub Date : 2020-12-02 Lori A. Lind; Teresa E. Lever; Nicole L. Nichols
We recently developed an inducible model of dysphagia using intralingual injection of cholera toxin B conjugated to saporin (CTB‐SAP) to cause death of hypoglossal neurons. In this study we aimed to evaluate tongue morphology and ultrastructural changes in hypoglossal neurons and nerve fibers in this model.
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