The purpose of this study was to investigate in vivo median nerve longitudinal mobility in different segments of the carpal tunnel associated with active finger motion in carpal tunnel syndrome (CTS) patients in a comparison with healthy controls.

In August 2013, the Centers for Medicare and Medicaid Services (CMS) Open Payments Program (OPP) made eligible payment information publicly available. Data about industry payments to neuromuscular neurologists are lacking.

M Scan‐Fit, an automated method for motor unit number estimation (MUNE), was assessed in muscles innervated by the facial nerve.

We report the case of a patient with muscle‐specific kinase (MuSK) antibody–positive myasthenia gravis (MG) who developed coronavirus disease‐2019 (COVID‐19). We report the clinical course of COVID‐19 focusing on the MG postintervention status in this patient. The patient, a 66‐year‐old woman, was diagnosed with MG at 44 years of age. At the time of initial MG diagnosis, she presented with dysphagia

Nephropathic cystinosis is a lysosomal storage disorder with late‐onset systemic complications, such as myopathy and dysphagia. Currently employed outcome measures lack sensitivity and responsiveness for dysphagia and myopathy, a limitation to clinical trial readiness.

MRI is a helpful tool for monitoring disease progression in late‐onset Pompe disease (LOPD). Our study aimed to evaluate if muscle diffusion tensor imaging (mDTI) shows alterations in muscles of LOPD patients with <10% fat‐fraction. We evaluated 6 thigh and 7 calf muscles (both legs) of 18 LOPD and 29 healthy controls (HC) with muscle diffusion tensor imaging (mDTI), T1w, and mDixonquant sequences

Escalating drug costs place patients at risk for financial toxicity and demand that physicians understand and act on the ethical and economic principles related to drug pricing. This manuscript reviews these principles and provides clinicians with a framework to think about the value of the drugs prescribed for patients with neuromuscular diseases. A key component of addressing the drug pricing crisis

Diabetic neuropathies are the most common type of neuropathies seen in clinical practice. These neuropathies can range clinically from asymptomatic to manifesting symptoms caused by motor, sensory, and autonomic nerve dysfunction. These neuropathies can affect the peripheral nervous system, pain receptors, cardiovascular, urogenital, and gastrointestinal systems. This monograph presents an overview

Drug prices in the United States have reached astounding heights, negatively impacting patients and society. The vast majority of prescription drug spending is on brand name drugs, which are protected from typical market pressures by FDA exclusivity and intellectual property patents. Drugs to treat “orphan” diseases, of particular relevance to neuromuscular clinicians, are some of the most expensive

The electrodiagnostic (EDX) examination with needle electromyography (EMG) is the most important means of testing for radiculopathy. This test has modest sensitivity but high specificity and complements imaging of the spine. In this second of a two‐part review, the implications of electrodiagnostic findings for diagnosis and clinical management of persons with radiculopathy are reviewed. An EMG confirmed

Data on combining molecular therapies that increase survival motor neuron protein for spinal muscular atrophy type 1 (SMA1) is lacking.

Chronic immune polyradiculopathies (sensory, motor and mixed) are uncommon.

We evaluated the association between muscle ultrasound, number of motor units, and clinical parameters, and assessed their utility for distinguishing ALS patients from healthy individuals.

We aimed to explore fatigue in chronic inflammatory demyelinating polyneuropathy (CIDP) as it relates to disease activity status.

We performed an observational, natural history study of males with in‐frame dystrophin gene deletions causing Becker muscular dystrophy (BMD). A prospective natural history study collected longitudinal medical, strength, and timed function assessments. Eighty‐three participants with genetically confirmed BMD were enrolled (age range 5.6–75.4 years). Lower extremity function and the percentage of participants

The time interval between 2 potential components of the same motor unit potential (MUP) is measured for jitter analysis. Enhanced jitter is generally thought to result from impaired neuromuscular transmission as occurs in myasthenia gravis or during reinnervation. Within a database of conventional video‐electromyography (EMG) recordings 4 MUP with peculiar jitter patterns were identified. In 1 spontaneously

The sonographic appearance of soft tissue can be altered by trauma and positional change with torsional stress. This creates challenges for ultrasonographic interpretation because most descriptive literature and standard instructional references are displayed in anatomic neutral or other conventional positions. Knowledge of anatomic alteration and changes in sonographic appearance with torsional stress

Evidence‐based information about cerebrospinal fluid (CSF) levels of biomarkers in patients with amyotrophic lateral sclerosis (ALS) is limited.

Ankle foot orthoses (AFOs) are commonly prescribed to individuals with Charcot‐Marie‐Tooth disease (CMT). The aim of this study was to evaluate patient reported satisfaction with orthotic devices and services in individuals with CMT to provide preliminary data for advancing AFO development and improving clinical care.

In this study, we aimed to investigate the progression of peripheral nervous system involvement in Xeroderma pigmentosum group A (XP‐A)

Persons with back, neck, and limb symptoms constitute a major referral population to specialists in electrodiagnostic (EDX) medicine. The evaluation of these patients involves consideration of both the common and less common disorders. The EDX examination with needle electromyography (EMG) is the most important means of testing for radiculopathy. This test has modest sensitivity but high specificity

Guillain‐Barre Syndrome (GBS) is an inflammatory polyradiculoneuropathy associated with numerous viral infections. Recently, there have been many case reports describing the association between COVID‐19 and GBS but much remains unknown about the strength of the association and the features of GBS in this setting. We reviewed 37 published cases of GBS associated with COVID‐19 to summarize this information

The most common neuromuscular ultrasound abnormality in carpal tunnel syndrome is enlargement of the median nerve near the distal wrist crease, but sometimes the median nerve enlarges in the palm, just distal to the transverse carpal ligament. This study was conducted to devise a protocol for measuring the median nerve in the palm and to generate reference values for nerve cross‐sectional area at this

See article on pages 192–200 in this issue.

As the world accommodates to the coronavirus disease 2019 (COVID‐19) pandemic, routine in‐person medical services are resuming. The resumption of non urgent electrodiagnostic (EDX) testing faces unique challenges due to the long duration of the procedure and direct close contact with patients, including studies with risk of exposure to oropharyngeal secretions. We provide consensus guidance for resumption

Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in‐person visits that may now be unsafe or impossible. Evidence‐ and experience‐based treatment options, such as multidisciplinary team care

Fatigue is a recognized manifestation of immune‐mediated neuropathies, but its causes and implications are unclear. In this study, we explored the correlates of fatigue among a number of clinical parameters in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to better understand potential contributing factors and resulting consequences.

In contrast to needle electromyography (EMG), surface EMG recordings are painless. It is of interest to develop methods to analyze surface EMG for diagnostic purposes.

Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT).

Coronavirus disease 2019 (COVID‐19) has rapidly become a global pandemic, but little is known about its potential impact on patients with myasthenia gravis (MG).

Patients with myasthenia gravis (MG) may experience worsening symptoms outside of a clinical setting. A method of diagnosing and triaging such individuals would be valuable. This study gauged the viability of a nurse‐administered single breath count test (SBCT) over the telephone for assessing MG exacerbations.

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory coronavirus 2 (SARS‐CoV‐2), is associated with Guillain‐Barré syndrome (GBS).1-8 We describe a patient with quadriplegic GBS with dysautonomia preceded by mild COVID‐19–induced diarrhea. A 72‐year‐old man with coronary artery disease, hypertension, and alcohol abuse presented to a tertiary hospital with symmetric paresthesias and

Hereditary transthyretin‐mediated amyloidosis (hATTR) manifests as multisystem dysfunction, including progressive polyneuropathy. Inotersen, an antisense oligonucleotide, improved the course of neuropathic impairment in patients with hATTR in the pivotal NEURO‐TTR study (NCT01737398). To determine inotersen's impact on symptoms and patients' neuropathy experience, we performed a post hoc analysis of

Inotersen, an antisense oligonucleotide inhibitor of TTR protein production, demonstrated significant benefit versus placebo in the modified Neuropathy Impairment Score +7 neurophysiologic tests (mNIS+7) in patients with hereditary transthyretin‐mediated amyloidosis (hATTR) with polyneuropathy. This analysis assessed the mNIS+7 components by anatomic location and the Lower Limb Function (LLF) test

Dysferlin‐deficient murine muscle sustains severe damage after repeated eccentric contractions.

The main goal of this study was to determine the contribution of the anterior forearm muscles to the compound muscle action potential (CMAP) recorded from the extensor digitorum (ED) after proximal stimulation.

Quantitative electromyography of paraspinal muscle is a valuable diagnostic tool, but normative data are lacking.

The sensitivity of repetitive nerve stimulation (RNS) in myasthenia gravis (MG) is dependent on the cutoff for abnormal decrement.

The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, has become a pandemic. Here, we report a patient with Guillain‐Barré syndrome (GBS) who had evidence of a coronavirus disease 2019 (COVID‐19) infection, but was otherwise asymptomatic for COVID‐19 except for a low‐grade fever. A 53‐year‐old previously healthy woman presented with a 3‐day history of dysarthria

Coronavirus disease‐2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), is known for being a life‐threatening respiratory illnesses, but there is increasing evidence of neurological manifestations.1 Herein we report a patient with COVID‐19–associated inflammatory myopathy who presented with facial, bulbar, and proximal limb weakness. A 58‐year‐old woman presented

We sought to determine whether survival motor neuron (SMN) protein blood levels correlate with denervation and SMN2 copies in spinal muscular atrophy (SMA).

We thank Dr. Vinciguerra for her letter. She correctly points out that a pandemic is an evolving situation, rather than a static one, and recommendations may not apply to all time points during the pandemic. She describes an earlier pandemic scenario, which she terms the “contingency standard of care,” in which there are still sufficient resources to perform electrodiagnostic studies (EDX). It is in

Changes in radiation therapy practice and cancer incidence bring into question prior evidence suggesting that radiation therapy predominantly injures the brachial plexus upper trunk, while tumor invasion typically injures the lower trunk.

Erratum to “Inclusion‐body myositis and primary Sjögren syndrome: mechanisms for shared etiologies” by Limaye VS, Cash K, Smith C, et al. Muscle Nerve . 2020;61(5):570–574. doi:10.1002/mus.26830 There was an error in the abbreviation. The COX, cyclooxygenase should be corrected to cytochrome c oxidase. The same errors are also present “Case report section” and in “Figure 1” legend. We apologize for

Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear.

Limited data exist regarding myopathies with early or prominent dysphagia.

After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono‐innervated neuro‐muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ‐monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast

Our aim in this study was to identify the prevalence and clinical characteristics of LRP4/agrin‐antibody–positive double‐seronegative myasthenia gravis (DNMG).

Muscle disorders are characterized by differential involvement of various muscle groups. Among these, weakness predominantly affecting finger flexors is an uncommon pattern, most frequently found in sporadic inclusion‐body myositis. This finding is particularly significant when the full range of histopathological findings of inclusion‐body myositis is not found on muscle biopsy. Prominent finger flexor

With the exception of thymectomy, immune modulatory treatment strategies and clinical trials in myasthenia gravis over the past 50 y were mainly borrowed from experience in other nonneurologic autoimmune disorders. The current experimental therapy paradigm has significantly changed such that treatments directed against the pathological mechanisms specific to myasthenia gravis are being tested, in some