-
The development of the adult nervous system in the annelid Owenia fusiformis Neural. Dev. (IF 3.6) Pub Date : 2024-02-21 Allan M. Carrillo-Baltodano, Rory D. Donnellan, Elizabeth A. Williams, Gáspár Jékely, José M. Martín-Durán
The evolutionary origins of animal nervous systems remain contentious because we still have a limited understanding of neural development in most major animal clades. Annelids — a species-rich group with centralised nervous systems — have played central roles in hypotheses about the origins of animal nervous systems. However, most studies have focused on adults of deeply nested species in the annelid
-
A cell atlas of the larval Aedes aegypti ventral nerve cord Neural. Dev. (IF 3.6) Pub Date : 2024-01-31 Chang Yin, Takeshi Morita, Jay Z. Parrish
Mosquito-borne diseases account for nearly 1 million human deaths annually, yet we have a limited understanding of developmental events that influence host-seeking behavior and pathogen transmission in mosquitoes. Mosquito-borne pathogens are transmitted during blood meals, hence adult mosquito behavior and physiology have been intensely studied. However, events during larval development shape adult
-
Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage Neural. Dev. (IF 3.6) Pub Date : 2024-01-02 Panagiotis Tsimpos, Simon Desiderio, Pauline Cabochette, Philippe Poelvoorde, Sadia Kricha, Luc Vanhamme, Coralie Poulard, Eric J. Bellefroid
Prdm12 is an epigenetic regulator expressed in developing and mature nociceptive neurons, playing a key role in their specification during neurogenesis and modulating pain sensation at adulthood. In vitro studies suggested that Prdm12 recruits the methyltransferase G9a through its zinc finger domains to regulate target gene expression, but how Prdm12 interacts with G9a and whether G9a plays a role
-
Imp is expressed in INPs and newborn neurons where it regulates neuropil targeting in the central complex Neural. Dev. (IF 3.6) Pub Date : 2023-11-29 Jordan A. Munroe, Chris Q. Doe
The generation of neuronal diversity remains incompletely understood. In Drosophila, the central brain is populated by neural stem cells derived from progenitors called neuroblasts (NBs). There are two types of NBs, type 1 and 2. T1NBs have a relatively simple lineage, whereas T2NBs expand and diversify the neural population with the generation of intermediate neural progenitors (INPs), contributing
-
Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells Neural. Dev. (IF 3.6) Pub Date : 2023-11-28 Samantha J. England, Amber K. Rusnock, Amra Mujcic, Angelica Kowalchuk, Sarah de Jager, William C. Hilinski, José L. Juárez-Morales, Matthew E. Smith, Ginny Grieb, Santanu Banerjee, Katharine E. Lewis
V0v spinal interneurons are highly conserved, glutamatergic, commissural neurons that function in locomotor circuits. We have previously shown that Evx1 and Evx2 are required to specify the neurotransmitter phenotype of these cells. However, we still know very little about the gene regulatory networks that act downstream of these transcription factors in V0v cells. To identify candidate members of
-
Neocortex neurogenesis and maturation in the African greater cane rat Neural. Dev. (IF 3.6) Pub Date : 2023-10-13 Oluwaseun Mustapha, Thomas Grochow, James Olopade, Simone A. Fietz
Neocortex development has been extensively studied in altricial rodents such as mouse and rat. Identification of alternative animal models along the “altricial-precocial” spectrum in order to better model and understand neocortex development is warranted. The Greater cane rat (GCR, Thyronomys swinderianus) is an indigenous precocial African rodent. Although basic aspects of brain development in the
-
Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery Neural. Dev. (IF 3.6) Pub Date : 2023-10-07 Judith A. Tello, Linan Jiang, Yitshak Zohar, Linda L. Restifo
CASK-related neurodevelopmental disorders are untreatable. Affected children show variable severity, with microcephaly, intellectual disability (ID), and short stature as common features. X-linked human CASK shows dosage sensitivity with haploinsufficiency in females. CASK protein has multiple domains, binding partners, and proposed functions at synapses and in the nucleus. Human and Drosophila CASK
-
Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon Neural. Dev. (IF 3.6) Pub Date : 2023-09-08 Mary Jo Talley, Diana Nardini, Lisa A. Ehrman, Q. Richard Lu, Ronald R. Waclaw
E-proteins encoded by Tcf3, Tcf4, and Tcf12 are class I basic helix-loop-helix (bHLH) transcription factors (TFs) that are thought to be widely expressed during development. However, their function in the developing brain, specifically in the telencephalon remains an active area of research. Our study examines for the first time if combined loss of two E-proteins (Tcf3 and Tcf12) influence distinct
-
Correction: Lrig1 expression identifies quiescent stem cells in the ventricular‑subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation Neural. Dev. (IF 3.6) Pub Date : 2023-05-23 Hyung-song Nam, Mario R. Capecchi
Correction: Neural Dev 18, 1 (2023) https://doi.org/10.1186/s13064-022-00169-1 The authors would like to correct errors and update two figures in the original publication of the article [1]. 1. Page 2, “All mouse lines were backcrossed for at least 6 generations” corrected to “All mouse lines were backcrossed for at least 4 generations”. 2. Page 4, “0.1 M boric acid pH 8” corrected to “0.1 M sodium
-
Correction: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life Neural. Dev. (IF 3.6) Pub Date : 2023-05-19 Hyung-song Nam, Mario R. Capecchi
Correction: Neural Dev 15, 3 (2020) https://doi.org/10.1186/s13064-020-00139-5 The authors would like to correct errors in the original publication of the article [1]. 1. Page 2, “the G4 embryonic stem cells derived from 129S6/SvEvTac × C57BL/6Ncr F1 embryos” corrected to “the G4 embryonic stem cells derived from a 129S6/SvEvTac × C57BL/6Ncr F1 embryo”. 2. Page 6, “In addition to our line of investigation
-
Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition Neural. Dev. (IF 3.6) Pub Date : 2023-04-27 Matthew B. Pomaville, Kevin M. Wright
The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to their functions, yet the mechanisms which regulate this organization remain unclear. Using a combination of genetic and molecular labeling approaches, we examined the development of mouse hair
-
Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation Neural. Dev. (IF 3.6) Pub Date : 2023-01-11 Nam, Hyung-song, Capecchi, Mario R.
We previously identified Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) as a marker of long-term neurogenic stem cells in the lateral wall of the adult mouse brain. The morphology of the stem cells thus identified differed from the canonical B1 type stem cells, raising a question about their cellular origin. Thus, we investigated the development of these stem cells in the postnatal
-
Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development Neural. Dev. (IF 3.6) Pub Date : 2022-11-22 Bollmann, Christian, Schöning, Susanne, Kotschnew, Katharina, Grosse, Julia, Heitzig, Nicole, Fischer von Mollard, Gabriele
Neurons are highly specialized cells with a complex morphology generated by various membrane trafficking steps. They contain Golgi outposts in dendrites, which are formed from somatic Golgi tubules. In trafficking membrane fusion is mediated by a specific combination of SNARE proteins. A functional SNARE complex contains four different helices, one from each SNARE subfamily (R-, Qa, Qb and Qc). Loss
-
Correction: A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages Neural. Dev. (IF 3.6) Pub Date : 2022-10-26 Corrales, Marc, Cocanougher, Benjamin T., Kohn, Andrea B., Wittenbach, Jason D., Long, Xi S., Lemire, Andrew, Cardona, Albert, Singer, Robert H., Moroz, Leonid L., Zlatic, Marta
Correction: Neural Dev 17, 8 (2022) https://doi.org/10.1186/s13064-022-00164-6 Following publication of the original article [1], the authors identified an error in Fig. 6. The correct figure is shown on the following page. Fig. 6 Temporal changes in marker composition. The Seurat algorithm of reciprocal-PCA allows to find matched populations of cells across our differently aged samples enabling the
-
Dpr10 and Nocte are required for Drosophila motor axon pathfinding Neural. Dev. (IF 3.6) Pub Date : 2022-10-21 Lobb-Rabe, Meike, DeLong, Katherine, Salazar, Rio J., Zhang, Ruiling, Wang, Yupu, Carrillo, Robert A.
The paths axons travel to reach their targets and the subsequent synaptic connections they form are highly stereotyped. How cell surface proteins (CSPs) mediate these processes is not completely understood. The Drosophila neuromuscular junction (NMJ) is an ideal system to study how pathfinding and target specificity are accomplished, as the axon trajectories and innervation patterns are known and easily
-
mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons Neural. Dev. (IF 3.6) Pub Date : 2022-10-15 Sami, Josephine D., Spitale, Robert C., Cleary, Michael D.
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in metazoans and is particularly abundant in the central nervous system. The extent to which m6A is dynamically regulated and whether m6A contributes to cell type-specific mRNA metabolism in the nervous system, however, is largely unknown. To address these knowledge gaps, we mapped m6A and measured mRNA decay in neural progenitors
-
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages Neural. Dev. (IF 3.6) Pub Date : 2022-08-24 Corrales, Marc, Cocanougher, Benjamin T., Kohn, Andrea B., Wittenbach, Jason D., Long, Xi S., Lemire, Andrew, Cardona, Albert, Singer, Robert H., Moroz, Leonid L., Zlatic, Marta
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene expression atlas of the Drosophila larval central nervous system composed of 131,077 single cells across three developmental stages (1 h, 24 h and 48 h after hatching). We identify 67 distinct
-
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts Neural. Dev. (IF 3.6) Pub Date : 2022-08-24 Dillon, Noah, Cocanougher, Ben, Sood, Chhavi, Yuan, Xin, Kohn, Andrea B, Moroz, Leonid L, Siegrist, Sarah E, Zlatic, Marta, Doe, Chris Q.
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We identify multiple progenitor subtypes – both stem cell-like neuroblasts and intermediate progenitors – that change gene expression across larval development, and report on new
-
Early development of the cochlea of the common marmoset, a non-human primate model Neural. Dev. (IF 3.6) Pub Date : 2022-05-07 Hosoya, Makoto, Fujioka, Masato, Okahara, Junko, Yoshimatsu, Sho, Okano, Hideyuki, Ozawa, Hiroyuki
Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between rodents and humans have been reported. To bridge these differences, we investigated early otic development of a non-human primate
-
DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target Neural. Dev. (IF 3.6) Pub Date : 2022-04-15 Santos, Rommel Andrew, Del Rio, Rodrigo, Alvarez, Alexander Delfin, Romero, Gabriela, Vo, Brandon Zarate, Cohen-Cory, Susana
The Xenopus retinotectal circuit is organized topographically, where the dorsal–ventral axis of the retina maps respectively on to the ventral-dorsal axis of the tectum; axons from the nasal-temporal axis of the retina project respectively to the caudal-rostral axis of the tectum. Studies throughout the last two decades have shown that mechanisms involving molecular recognition of proper termination
-
Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting Neural. Dev. (IF 3.6) Pub Date : 2022-03-05 Cheng, Ryan P., Dang, Puneet, Taku, Alemji A., Moon, Yoon Ji, Pham, Vi, Sun, Xiaohe, Zhao, Ethan, Raper, Jonathan A.
Correction to: Neural Dev 17, 1 (2022) https://doi.org/10.1186/s13064-021-00157-x Following publication of the original article [1], the last two figures in the paper were misordered during the publication process and references to one of the figures were omitted. The figure entitled “Both nrp2a and nrp2b act in the same pathway with sema3fa” formerly appeared as Fig. 6 and now appears correctly as
-
Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts Neural. Dev. (IF 3.6) Pub Date : 2022-02-17 Hafer, Terry L., Patra, Sofiya, Tagami, Daiki, Kohwi, Minoree
Neural progenitors produce diverse cells in a stereotyped birth order, but can specify each cell type for only a limited duration. In the Drosophila embryo, neuroblasts (neural progenitors) specify multiple, distinct neurons by sequentially expressing a series of temporal identity transcription factors with each division. Hunchback (Hb), the first of the series, specifies early-born neuronal identity
-
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling Neural. Dev. (IF 3.6) Pub Date : 2022-01-14 Gingrich, Ellen C., Case, Kendra, Garcia, A. Denise R.
The molecular signaling pathway, Sonic hedgehog (Shh), is critical for the proper development of the central nervous system. The requirement for Shh signaling in neuronal and oligodendrocyte development in the developing embryo are well established. However, Shh activity is found in discrete subpopulations of astrocytes in the postnatal and adult brain. Whether Shh signaling plays a role in astrocyte
-
Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting Neural. Dev. (IF 3.6) Pub Date : 2022-01-03 Cheng, Ryan P., Dang, Puneet, Taku, Alemji A., Moon, Yoon Ji, Pham, Vi, Sun, Xiaohe, Zhao, Ethan, Raper, Jonathan A.
Olfactory Sensory Neuron (OSN) axons project from the zebrafish olfactory epithelium to reproducible intermediate target locations in the olfactory bulb called protoglomeruli at early stages in development. Two classes of OSNs expressing either OMP or TRPC2 exclusively target distinct, complementary protoglomeruli. Using RNAseq, we identified axon guidance receptors nrp2a and nrp2b, and their ligand
-
The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination Neural. Dev. (IF 3.6) Pub Date : 2021-11-29 Hay, Curtis M., Jackson, Stacey, Mitew, Stanislaw, Scott, Daniel J., Koenning, Matthias, Bensen, AeSoon L., Bujalka, Helena, Kilpatrick, Trevor J., Emery, Ben
Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin in order to allow rapid electrical conduction. Establishing the proper pattern of myelin in neural circuits requires communicative axo-glial interactions, however, the molecular interactions that occur between oligodendrocytes and axons
-
Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification Neural. Dev. (IF 3.6) Pub Date : 2021-09-21 Muzyka, Vladimir Vladimirovich, Badea, Tudor Constantin
While the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with neurotrophic signaling is largely unexplored. In mice, the transcription factor Brn3a/Pou4f1 is expressed in most RGCs, and is required for the specification of RGCs with small dendritic arbors. The Glial Derived Neurotrophic Factor (GDNF) receptor Ret is expressed in
-
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons Neural. Dev. (IF 3.6) Pub Date : 2021-08-06 Miller, Daniel S., Wright, Kevin M.
The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in the mammalian brain to initially recognize their postsynaptic partners remain largely unknown. The transmembrane glycoprotein Dystroglycan is localized to inhibitory synapses in pyramidal neurons
-
A two-step actin polymerization mechanism drives dendrite branching Neural. Dev. (IF 3.6) Pub Date : 2021-07-19 Rebecca Shi, Daniel A. Kramer, Baoyu Chen, Kang Shen
Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched dendrites, neurons use external cues and cell surface receptors to coordinate intracellular cytoskeletal organization; however, the molecular mechanisms of how this signaling forms branched dendrites
-
Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis Neural. Dev. (IF 3.6) Pub Date : 2021-02-02 Gabriela Edwards-Faret, Karina González-Pinto, Arantxa Cebrián-Silla, Johany Peñailillo, José Manuel García-Verdugo, Juan Larraín
The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to spinal cord regeneration. We compared the cellular response to spinal cord injury between the regenerative and non-regenerative stages of Xenopus laevis. For this analysis, we used electron
-
The role of astrocyte‐mediated plasticity in neural circuit development and function Neural. Dev. (IF 3.6) Pub Date : 2021-01-07 Nelson A. Perez-Catalan, Chris Q. Doe, Sarah D. Ackerman
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range from short-term modifications on the order of milliseconds, to long-term rearrangement of neural architecture that could last for the lifetime of the organism. Neural plasticity is most prominent
-
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex Neural. Dev. (IF 3.6) Pub Date : 2020-11-07 Johanna Tomorsky, Philip R. L. Parker, Chris Q. Doe, Cristopher M. Niell
Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell-adhesion molecule with previously described roles in synapse formation and maintenance. This protein and its binding partner, nectin-1, are selectively expressed in upper-layer neurons of mouse
-
Individual neuronal subtypes control initial myelin sheath growth and stabilization Neural. Dev. (IF 3.6) Pub Date : 2020-09-28 Heather N. Nelson, Anthony J. Treichel, Erin N. Eggum, Madeline R. Martell, Amanda J. Kaiser, Allie G. Trudel, James R. Gronseth, Samantha T. Maas, Silas Bergen, Jacob H. Hines
In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axon wrapping, nascent myelin sheath formation, concentric wrapping and sheath elongation, and sheath stabilization or pruning by oligodendrocytes. Although axonal signals influence the overall process
-
Synapse development and maturation at the drosophila neuromuscular junction. Neural. Dev. (IF 3.6) Pub Date : 2020-08-02 Vivian T Chou,Seth A Johnson,David Van Vactor
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions between a presynaptic neuron and a postsynaptic target that form through a series of diverse cellular and subcellular events under the control of complex signaling networks. Once established, the synapse
-
The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction. Neural. Dev. (IF 3.6) Pub Date : 2020-08-02 Shiyun Feng,Evanthia Zacharioudaki,Kat Millen,Sarah J Bray
Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protected under conditions of nutrition restriction but the mechanisms responsible are not fully understood. As amino acid transporters (Solute Carrier transporters, SLCs), such as SLC36, have important
-
A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage. Neural. Dev. (IF 3.6) Pub Date : 2020-07-28 Austin Seroka,Rita M Yazejian,Sen-Lin Lai,Chris Q Doe
Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal classes” of neurons that share a transcription factor identity and common morphology. In Drosophila, two cardinal classes are Even-skipped (Eve)+ motor neurons projecting to dorsal longitudinal muscles
-
Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes. Neural. Dev. (IF 3.6) Pub Date : 2020-07-10 Jizhen Zou,Fang Wang,Xueyan Yang,Hongyan Wang,Lee Niswander,Ting Zhang,Huili Li
Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to establish association between biological functions and subphenotypes. However, the knowledge about association in human remains still very poor. High throughput targeted genome DNA sequencing were
-
The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance. Neural. Dev. (IF 3.6) Pub Date : 2020-05-02 Han Sian Joshua Cheong,Mark Nona,Samantha Barbara Guerra,Mark Francis VanBerkum
BACKGROUND Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work identified the 'first quarter' (1Q) of the CTD as essential. Here, we link the physical interactions of 1Q binding partners to Abl's function in axon guidance. METHODS Protein binding
-
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease. Neural. Dev. (IF 3.6) Pub Date : 2020-04-26 Andrew C Giles,Brock Grill
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory
-
Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells Neural. Dev. (IF 3.6) Pub Date : 2020-03-19 Sruti Patoori, Nathalie Jean-Charles, Ariana Gopal, Sacha Sulaiman, Sneha Gopal, Brian Wang, Benjamin Souferi, Mark M. Emerson
The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-restricted RPCs have recently been identified, with limited mitotic potential and cell fate possibilities compared to multipotent RPCs. One population of fate-restricted RPCs, marked by activity
-
Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function. Neural. Dev. (IF 3.6) Pub Date : 2020-03-17 Elizabeth M McNeill,Cheryl Thompson,Brett Berke,Vivian T Chou,Jannette Rusch,April Duckworth,Jamin DeProto,Alicia Taylor,Julie Gates,Frank Gertler,Haig Keshishian,David Van Vactor
BACKGROUND Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-associated protein Enabled (Ena) is known to regulate development of the Drosophila larval neuromuscular junction through a postsynaptic mechanism. However, the functions and regulation
-
Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural. Dev. (IF 3.6) Pub Date : 2020-03-17 Hyung-Song Nam,Mario R Capecchi
Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in cultured Id1high neural stem cells obtained from the lateral walls lining the lateral ventricles of the adult mouse brain. Thus, we investigated whether Lrig1 expression also identifies stem cells in
-
An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells. Neural. Dev. (IF 3.6) Pub Date : 2020-02-20 Darshan Sapkota,Joseph D Dougherty
Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround smaller axons and do not myelinate. While tools exist for genetic targeting of Schwann cell precursors and myelinating Schwann cells, such reagents have been challenging to generate specifically
-
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries. Neural. Dev. (IF 3.6) Pub Date : 2020-01-09 Raihan Mohammed,Kaesi Opara,Rahul Lall,Utkarsh Ojha,Jinpo Xiang
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be crippling to a person's health. Spontaneous recovery can occur from plastic changes, but it is minimal. The absence of regeneration is due to the inhibitory environment of the CNS as well
-
Microglia in the developing retina. Neural. Dev. (IF 3.6) Pub Date : 2019-12-30 Fenge Li,Danye Jiang,Melanie A Samuel
Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in part because such analysis is challenging in the brain where neurons and synapses are intermingled and connectivity is only beginning to be mapped. Here, we discuss the features and function of microglia
-
The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology. Neural. Dev. (IF 3.6) Pub Date : 2019-11-09 Ines Hahn,André Voelzmann,Yu-Ting Liew,Beatriz Costa-Gomes,Andreas Prokop
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesion sites in pathological processes of ageing, injury and neurodegeneration. The morphology and physiology of axons crucially depends on the parallel bundles
-
sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS. Neural. Dev. (IF 3.6) Pub Date : 2019-10-24 Madison Gonsior,Afshan Ismat
Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to their proper final position. The lateral chordotonal organs (lch5) of the Drosophila peripheral nervous system (PNS) are composed of five sensory neurons surrounded by four different glial cells,
-
Commissural axon guidance in the developing spinal cord: from Cajal to the present day. Neural. Dev. (IF 3.6) Pub Date : 2019-09-12 J D Comer,S Alvarez,S J Butler,J A Kaltschmidt
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners. Essential to this process is the ability of developing axons to navigate guidance molecules presented by specialized populations of cells. These cells partition the distance traveled
-
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development. Neural. Dev. (IF 3.6) Pub Date : 2019-08-30 Jasmine A Lucas,Tiffany M Schmidt
BACKGROUND Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are also the first light sensitive cells in the developing retina, and have been implicated in a number of retinal developmental processes such as pruning of retinal vasculature and refinement
-
Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis. Neural. Dev. (IF 3.6) Pub Date : 2019-03-13 Manon Azaïs,Eric Agius,Stéphane Blanco,Angie Molina,Fabienne Pituello,Jean-Marc Tregan,Anaïs Vallet,Jacques Gautrais
In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of this process, from tissue-scale morphogens patterning to intrinsic determinants in neural progenitor cells. In a previous study (Bonnet et al. eLife 7, 2018), we have shown that the CDC25B phosphatase
-
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse. Neural. Dev. (IF 3.6) Pub Date : 2019-03-12 Lauren N Miterko,Joshua J White,Tao Lin,Amanda M Brown,Kevin J O'Donovan,Roy V Sillitoe
BACKGROUND Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects in size and morphology. METHODS To resolve how this compensation occurs, we asked how
-
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain. Neural. Dev. (IF 3.6) Pub Date : 2019-02-27 Ozge Yildiz,Gerald B Downes,Charles G Sagerström
BACKGROUND Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral axis of the neural tube. Each domain is characterized by a unique combination of transcription factors (TFs) that promote a specific fate, while repressing fates of adjacent domains
-
Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors. Neural. Dev. (IF 3.6) Pub Date : 2019-02-14 Alexandre Wojcinski,Morgane Morabito,Andrew K Lawton,Daniel N Stephen,Alexandra L Joyner
BACKGROUND The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule cell precursors (GCPs) in the external granule cell layer (EGL), a key step for generating cerebellar foliation and the correct number of granule cells
-
TrkB expression and dependence divides gustatory neurons into three subpopulations. Neural. Dev. (IF 3.6) Pub Date : 2019-01-28 Jennifer Rios-Pilier,Robin F Krimm
BACKGROUND During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate it. Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor
-
An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural. Dev. (IF 3.6) Pub Date : 2019-01-18 Catarina Catela,Edgar Correa,Kailong Wen,Jihad Aburas,Laura Croci,G Giacomo Consalez,Paschalis Kratsios
BACKGROUND Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun to elucidate the genetic programs that control animal locomotion. In striking contrast, the molecular mechanisms underlying the development of axial muscle-innervating MNs, which control
-
Degeneration of saccular hair cells caused by MITF gene mutation. Neural. Dev. (IF 3.6) Pub Date : 2019-01-11 Yi Du,Li-Li Ren,Qing-Qing Jiang,Xing-Jian Liu,Fei Ji,Yue Zhang,Shuo-Long Yuan,Zi-Ming Wu,Wei-Wei Guo,Shi-Ming Yang
BACKGROUND Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. Patients with WS may also experience primary vestibular symptoms. Most of the current WS studies did not discuss the relationship between WS and abnormal vestibular function. Our study
-
The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus. Neural. Dev. (IF 3.6) Pub Date : 2018-12-12 Guela Sokhadze,Tania A Seabrook,William Guido
BACKGROUND The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensive inquiry, how and when nonretinal projections innervate this nucleus remains largely unexplored. In this study, we examined the development of a major nonretinal projection to dLGN
-
Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1. Neural. Dev. (IF 3.6) Pub Date : 2018-11-22 Nathalie Jean-Charles,Diego F Buenaventura,Mark M Emerson
BACKGROUND Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new functional photoreceptors to replace those lost in the diseased retina. Cis-regulatory elements specific to cones, rods, or both types of photoreceptors are critical
-
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe. Neural. Dev. (IF 3.6) Pub Date : 2018-11-22 Esteban G Contreras,Boris Egger,Katrina S Gold,Andrea H Brand
BACKGROUND Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial
-
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish. Neural. Dev. (IF 3.6) Pub Date : 2018-11-17 Yona Goldshmit,Jean Kitty K Y Tang,Ashley L Siegel,Phong D Nguyen,Jan Kaslin,Peter D Currie,Patricia R Jusuf
BACKGROUND Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to
-
Live imaging of developing mouse retinal slices. Neural. Dev. (IF 3.6) Pub Date : 2018-09-15 Anthony P Barrasso,Shang Wang,Xuefei Tong,Audrey E Christiansen,Irina V Larina,Ross A Poché
BACKGROUND Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluorescent microscopy with the goal of directly observing dynamic cellular events. However, retinal tissue thickness imposes significant technical limitations. To obtain 3-dimensional