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The role of astrocyte‐mediated plasticity in neural circuit development and function Neural. Dev. (IF 2.63) Pub Date : 2021-01-07 Nelson A. Perez-Catalan; Chris Q. Doe; Sarah D. Ackerman
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range from short-term modifications on the order of milliseconds, to long-term rearrangement of neural architecture that could last for the lifetime of the organism. Neural plasticity is most prominent
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Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex Neural. Dev. (IF 2.63) Pub Date : 2020-11-07 Johanna Tomorsky; Philip R. L. Parker; Chris Q. Doe; Cristopher M. Niell
Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell-adhesion molecule with previously described roles in synapse formation and maintenance. This protein and its binding partner, nectin-1, are selectively expressed in upper-layer neurons of mouse
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Individual neuronal subtypes control initial myelin sheath growth and stabilization Neural. Dev. (IF 2.63) Pub Date : 2020-09-28 Heather N. Nelson; Anthony J. Treichel; Erin N. Eggum; Madeline R. Martell; Amanda J. Kaiser; Allie G. Trudel; James R. Gronseth; Samantha T. Maas; Silas Bergen; Jacob H. Hines
In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axon wrapping, nascent myelin sheath formation, concentric wrapping and sheath elongation, and sheath stabilization or pruning by oligodendrocytes. Although axonal signals influence the overall process
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Synapse development and maturation at the drosophila neuromuscular junction. Neural. Dev. (IF 2.63) Pub Date : 2020-08-02 Vivian T Chou,Seth A Johnson,David Van Vactor
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions between a presynaptic neuron and a postsynaptic target that form through a series of diverse cellular and subcellular events under the control of complex signaling networks. Once established, the synapse
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The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction. Neural. Dev. (IF 2.63) Pub Date : 2020-08-02 Shiyun Feng,Evanthia Zacharioudaki,Kat Millen,Sarah J Bray
Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protected under conditions of nutrition restriction but the mechanisms responsible are not fully understood. As amino acid transporters (Solute Carrier transporters, SLCs), such as SLC36, have important
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A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage. Neural. Dev. (IF 2.63) Pub Date : 2020-07-28 Austin Seroka,Rita M Yazejian,Sen-Lin Lai,Chris Q Doe
Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal classes” of neurons that share a transcription factor identity and common morphology. In Drosophila, two cardinal classes are Even-skipped (Eve)+ motor neurons projecting to dorsal longitudinal muscles
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Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes. Neural. Dev. (IF 2.63) Pub Date : 2020-07-10 Jizhen Zou,Fang Wang,Xueyan Yang,Hongyan Wang,Lee Niswander,Ting Zhang,Huili Li
Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to establish association between biological functions and subphenotypes. However, the knowledge about association in human remains still very poor. High throughput targeted genome DNA sequencing were
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The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance. Neural. Dev. (IF 2.63) Pub Date : 2020-05-02 Han Sian Joshua Cheong,Mark Nona,Samantha Barbara Guerra,Mark Francis VanBerkum
BACKGROUND Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work identified the 'first quarter' (1Q) of the CTD as essential. Here, we link the physical interactions of 1Q binding partners to Abl's function in axon guidance. METHODS Protein binding
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Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease. Neural. Dev. (IF 2.63) Pub Date : 2020-04-26 Andrew C Giles,Brock Grill
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory
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Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells Neural. Dev. (IF 2.63) Pub Date : 2020-03-19 Sruti Patoori; Nathalie Jean-Charles; Ariana Gopal; Sacha Sulaiman; Sneha Gopal; Brian Wang; Benjamin Souferi; Mark M. Emerson
The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-restricted RPCs have recently been identified, with limited mitotic potential and cell fate possibilities compared to multipotent RPCs. One population of fate-restricted RPCs, marked by activity
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Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function. Neural. Dev. (IF 2.63) Pub Date : 2020-03-17 Elizabeth M McNeill,Cheryl Thompson,Brett Berke,Vivian T Chou,Jannette Rusch,April Duckworth,Jamin DeProto,Alicia Taylor,Julie Gates,Frank Gertler,Haig Keshishian,David Van Vactor
BACKGROUND Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-associated protein Enabled (Ena) is known to regulate development of the Drosophila larval neuromuscular junction through a postsynaptic mechanism. However, the functions and regulation
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Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural. Dev. (IF 2.63) Pub Date : 2020-03-17 Hyung-Song Nam,Mario R Capecchi
Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in cultured Id1high neural stem cells obtained from the lateral walls lining the lateral ventricles of the adult mouse brain. Thus, we investigated whether Lrig1 expression also identifies stem cells in
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An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells. Neural. Dev. (IF 2.63) Pub Date : 2020-02-20 Darshan Sapkota,Joseph D Dougherty
Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround smaller axons and do not myelinate. While tools exist for genetic targeting of Schwann cell precursors and myelinating Schwann cells, such reagents have been challenging to generate specifically
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Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries. Neural. Dev. (IF 2.63) Pub Date : 2020-01-09 Raihan Mohammed,Kaesi Opara,Rahul Lall,Utkarsh Ojha,Jinpo Xiang
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be crippling to a person's health. Spontaneous recovery can occur from plastic changes, but it is minimal. The absence of regeneration is due to the inhibitory environment of the CNS as well
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Microglia in the developing retina. Neural. Dev. (IF 2.63) Pub Date : 2019-12-30 Fenge Li,Danye Jiang,Melanie A Samuel
Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in part because such analysis is challenging in the brain where neurons and synapses are intermingled and connectivity is only beginning to be mapped. Here, we discuss the features and function of microglia
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The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology. Neural. Dev. (IF 2.63) Pub Date : 2019-11-09 Ines Hahn,André Voelzmann,Yu-Ting Liew,Beatriz Costa-Gomes,Andreas Prokop
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesion sites in pathological processes of ageing, injury and neurodegeneration. The morphology and physiology of axons crucially depends on the parallel bundles
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sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS. Neural. Dev. (IF 2.63) Pub Date : 2019-10-24 Madison Gonsior,Afshan Ismat
Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to their proper final position. The lateral chordotonal organs (lch5) of the Drosophila peripheral nervous system (PNS) are composed of five sensory neurons surrounded by four different glial cells,
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Commissural axon guidance in the developing spinal cord: from Cajal to the present day. Neural. Dev. (IF 2.63) Pub Date : 2019-09-12 J D Comer,S Alvarez,S J Butler,J A Kaltschmidt
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners. Essential to this process is the ability of developing axons to navigate guidance molecules presented by specialized populations of cells. These cells partition the distance traveled
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Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development. Neural. Dev. (IF 2.63) Pub Date : 2019-08-30 Jasmine A Lucas,Tiffany M Schmidt
BACKGROUND Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are also the first light sensitive cells in the developing retina, and have been implicated in a number of retinal developmental processes such as pruning of retinal vasculature and refinement
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Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis. Neural. Dev. (IF 2.63) Pub Date : 2019-03-13 Manon Azaïs,Eric Agius,Stéphane Blanco,Angie Molina,Fabienne Pituello,Jean-Marc Tregan,Anaïs Vallet,Jacques Gautrais
In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of this process, from tissue-scale morphogens patterning to intrinsic determinants in neural progenitor cells. In a previous study (Bonnet et al. eLife 7, 2018), we have shown that the CDC25B phosphatase
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Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse. Neural. Dev. (IF 2.63) Pub Date : 2019-03-12 Lauren N Miterko,Joshua J White,Tao Lin,Amanda M Brown,Kevin J O'Donovan,Roy V Sillitoe
BACKGROUND Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects in size and morphology. METHODS To resolve how this compensation occurs, we asked how
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Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain. Neural. Dev. (IF 2.63) Pub Date : 2019-02-27 Ozge Yildiz,Gerald B Downes,Charles G Sagerström
BACKGROUND Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral axis of the neural tube. Each domain is characterized by a unique combination of transcription factors (TFs) that promote a specific fate, while repressing fates of adjacent domains
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Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors. Neural. Dev. (IF 2.63) Pub Date : 2019-02-14 Alexandre Wojcinski,Morgane Morabito,Andrew K Lawton,Daniel N Stephen,Alexandra L Joyner
BACKGROUND The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule cell precursors (GCPs) in the external granule cell layer (EGL), a key step for generating cerebellar foliation and the correct number of granule cells
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TrkB expression and dependence divides gustatory neurons into three subpopulations. Neural. Dev. (IF 2.63) Pub Date : 2019-01-28 Jennifer Rios-Pilier,Robin F Krimm
BACKGROUND During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate it. Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor
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An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural. Dev. (IF 2.63) Pub Date : 2019-01-18 Catarina Catela,Edgar Correa,Kailong Wen,Jihad Aburas,Laura Croci,G Giacomo Consalez,Paschalis Kratsios
BACKGROUND Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun to elucidate the genetic programs that control animal locomotion. In striking contrast, the molecular mechanisms underlying the development of axial muscle-innervating MNs, which control
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Degeneration of saccular hair cells caused by MITF gene mutation. Neural. Dev. (IF 2.63) Pub Date : 2019-01-11 Yi Du,Li-Li Ren,Qing-Qing Jiang,Xing-Jian Liu,Fei Ji,Yue Zhang,Shuo-Long Yuan,Zi-Ming Wu,Wei-Wei Guo,Shi-Ming Yang
BACKGROUND Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. Patients with WS may also experience primary vestibular symptoms. Most of the current WS studies did not discuss the relationship between WS and abnormal vestibular function. Our study
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The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus. Neural. Dev. (IF 2.63) Pub Date : 2018-12-12 Guela Sokhadze,Tania A Seabrook,William Guido
BACKGROUND The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensive inquiry, how and when nonretinal projections innervate this nucleus remains largely unexplored. In this study, we examined the development of a major nonretinal projection to dLGN
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Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1. Neural. Dev. (IF 2.63) Pub Date : 2018-11-22 Nathalie Jean-Charles,Diego F Buenaventura,Mark M Emerson
BACKGROUND Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new functional photoreceptors to replace those lost in the diseased retina. Cis-regulatory elements specific to cones, rods, or both types of photoreceptors are critical
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Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe. Neural. Dev. (IF 2.63) Pub Date : 2018-11-22 Esteban G Contreras,Boris Egger,Katrina S Gold,Andrea H Brand
BACKGROUND Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial
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Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish. Neural. Dev. (IF 2.63) Pub Date : 2018-11-17 Yona Goldshmit,Jean Kitty K Y Tang,Ashley L Siegel,Phong D Nguyen,Jan Kaslin,Peter D Currie,Patricia R Jusuf
BACKGROUND Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to
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Live imaging of developing mouse retinal slices. Neural. Dev. (IF 2.63) Pub Date : 2018-09-15 Anthony P Barrasso,Shang Wang,Xuefei Tong,Audrey E Christiansen,Irina V Larina,Ross A Poché
BACKGROUND Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluorescent microscopy with the goal of directly observing dynamic cellular events. However, retinal tissue thickness imposes significant technical limitations. To obtain 3-dimensional
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DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural. Dev. (IF 2.63) Pub Date : 2018-09-15 Rommel A Santos,Ariel J C Fuertes,Ginger Short,Kevin C Donohue,Hanjuan Shao,Julian Quintanilla,Parinaz Malakzadeh,Susana Cohen-Cory
BACKGROUND Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal circuits. Developing circuits rely on an array of molecular cues to shape arbor morphology, but the underlying mechanisms guiding the structural formation and interconnectivity of pre- and postsynaptic arbors in real time remain unclear. Here we explore how Down syndrome cell adhesion
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Genomic analysis of transcriptional networks directing progression of cell states during MGE development. Neural. Dev. (IF 2.63) Pub Date : 2018-09-14 Magnus Sandberg,Leila Taher,Jianxin Hu,Brian L Black,Alex S Nord,John L R Rubenstein
BACKGROUND Homeodomain (HD) transcription factor (TF) NKX2-1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the induction of TFs such as LHX6 and LHX8. NKX2-1 defines MGE regional identity in large part through transcriptional repression, while specification and maturation of GABAergic and cholinergic
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Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies. Neural. Dev. (IF 2.63) Pub Date : 2018-09-13 Uwe Ernsberger,Hermann Rohrer
Remarkable progress in a range of biomedical disciplines has promoted the understanding of the cellular components of the autonomic nervous system and their differentiation during development to a critical level. Characterization of the gene expression fingerprints of individual neurons and identification of the key regulators of autonomic neuron differentiation enables us to comprehend the development
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Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation. Neural. Dev. (IF 2.63) Pub Date : 2018-08-18 Evan L Nichols,Lauren A Green,Cody J Smith
BACKGROUND Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown. METHODS To address
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Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila. Neural. Dev. (IF 2.63) Pub Date : 2018-08-13 Bader Al-Anzi,Kai Zinn
BACKGROUND In an earlier study, we identified two neuronal populations, c673a and Fru-GAL4, that regulate fat storage in fruit flies. Both populations partially overlap with a structure in the insect brain known as the mushroom body (MB), which plays a critical role in memory formation. This overlap prompted us to examine whether the MB is also involved in fat storage homeostasis. METHODS Using a variety
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Mutations in dock1 disrupt early Schwann cell development. Neural. Dev. (IF 2.63) Pub Date : 2018-08-08 Rebecca L Cunningham,Amy L Herbert,Breanne L Harty,Sarah D Ackerman,Kelly R Monk
BACKGROUND In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann cells must undergo extensive cytoskeletal rearrangements in order to become mature, myelinating Schwann cells. The intracellular mechanisms that drive Schwann cell
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Does experience provide a permissive or instructive influence on the development of direction selectivity in visual cortex? Neural. Dev. (IF 2.63) Pub Date : 2018-07-12 Arani Roy,Ian K Christie,Gina M Escobar,Jason J Osik,Marjena Popović,Neil J Ritter,Andrea K Stacy,Shen Wang,Jozsef Fiser,Paul Miller,Stephen D Van Hooser
In principle, the development of sensory receptive fields in cortex could arise from experience-independent mechanisms that have been acquired through evolution, or through an online analysis of the sensory experience of the individual animal. Here we review recent experiments that suggest that the development of direction selectivity in carnivore visual cortex requires experience, but also suggest
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Structural aspects of plasticity in the nervous system of Drosophila. Neural. Dev. (IF 2.63) Pub Date : 2018-07-01 Atsushi Sugie,Giovanni Marchetti,Gaia Tavosanis
Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangements is in part maintained during adult life when it supports the animal's ability to adapt to a changing environment or to form lasting memories. Nonetheless, the signals triggering structural plasticity
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Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells. Neural. Dev. (IF 2.63) Pub Date : 2018-06-29 Vladimir Vladimirovich Muzyka,Matthew Brooks,Tudor Constantin Badea
BACKGROUND About 20-30 distinct Retinal Ganglion Cell (RGC) types transmit visual information from the retina to the brain. The developmental mechanisms by which RGCs are specified are still largely unknown. Brn3a is a member of the Brn3/Pou4f transcription factor family, which contains key regulators of RGC postmitotic specification. In particular, Brn3a ablation results in the loss of RGCs with small
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Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural. Dev. (IF 2.63) Pub Date : 2018-06-26 Priyanjali Ghosh,Jennifer M Maurer,Charles G Sagerström
BACKGROUND Previous work aimed at understanding the gene regulatory networks (GRNs) governing caudal hindbrain formation identified morphogens such as Retinoic Acid (RA) and Fibroblast growth factors (FGFs), as well as transcription factors like hoxb1b, hoxb1a, hnf1ba, and valentino as being required for rhombomere (r) r4-r6 formation in zebrafish. Considering that the caudal hindbrain is relatively
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Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system. Neural. Dev. (IF 2.63) Pub Date : 2018-06-07 Clare R Gamlin,Wan-Qing Yu,Rachel O L Wong,Mrinalini Hoon
Inhibition in the central nervous systems (CNS) is mediated by two neurotransmitters: gamma-aminobutyric acid (GABA) and glycine. Inhibitory synapses are generally GABAergic or glycinergic, although there are synapses that co-release both neurotransmitter types. Compared to excitatory circuits, much less is known about the cellular and molecular mechanisms that regulate synaptic partner selection and
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Strategies for assembling columns and layers in the Drosophila visual system. Neural. Dev. (IF 2.63) Pub Date : 2018-06-07 S Sean Millard,Matthew Y Pecot
A striking feature of neural circuit structure is the arrangement of neurons into regularly spaced ensembles (i.e. columns) and neural connections into parallel layers. These patterns of organization are thought to underlie precise synaptic connectivity and provide a basis for the parallel processing of information. In this article we discuss in detail specific findings that contribute to a framework
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Development, functional organization, and evolution of vertebrate axial motor circuits. Neural. Dev. (IF 2.63) Pub Date : 2018-06-01 Kristen P D'Elia,Jeremy S Dasen
Neuronal control of muscles associated with the central body axis is an ancient and essential function of the nervous systems of most animal species. Throughout the course of vertebrate evolution, motor circuits dedicated to control of axial muscle have undergone significant changes in their roles within the motor system. In most fish species, axial circuits are critical for coordinating muscle activation
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Homeostatic plasticity in neural development. Neural. Dev. (IF 2.63) Pub Date : 2018-06-01 Nai-Wen Tien,Daniel Kerschensteiner
Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their changing connectivity, neural circuits maintain relatively constant activity levels. Neural circuits achieve functional stability by homeostatic plasticity, which equipoises intrinsic excitability
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Tcf7L2 is essential for neurogenesis in the developing mouse neocortex. Neural. Dev. (IF 2.63) Pub Date : 2018-05-11 Olga Chodelkova,Jan Masek,Vladimir Korinek,Zbynek Kozmik,Ondrej Machon
Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells in the ventricular zone and for differentiation of intermediate progenitors in the subventricular zone. We detected abundant expression of two transcrtiption factors mediating canonical Wnt signalling
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Astrocytes, neurons, synapses: a tripartite view on cortical circuit development. Neural. Dev. (IF 2.63) Pub Date : 2018-05-01 Isabella Farhy-Tselnicker,Nicola J Allen
In the mammalian cerebral cortex neurons are arranged in specific layers and form connections both within the cortex and with other brain regions, thus forming a complex mesh of specialized synaptic connections comprising distinct circuits. The correct establishment of these connections during development is crucial for the proper function of the brain. Astrocytes, a major type of glial cell, are important
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Neural circuits driving larval locomotion in Drosophila. Neural. Dev. (IF 2.63) Pub Date : 2018-04-19 Matthew Q Clark,Aref Arzan Zarin,Arnaldo Carreira-Rosario,Chris Q Doe
More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit
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Linking neuronal lineage and wiring specificity. Neural. Dev. (IF 2.63) Pub Date : 2018-04-13 Hongjie Li,S Andrew Shuster,Jiefu Li,Liqun Luo
Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between lineage
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Monocular enucleation alters retinal waves in the surviving eye. Neural. Dev. (IF 2.63) Pub Date : 2018-03-24 Samuel Wilson Failor,Arash Ng,Hwai-Jong Cheng
BACKGROUND Activity in neurons drives afferent competition that is critical for the refinement of nascent neural circuits. In ferrets, when an eye is lost in early development, surviving retinogeniculate afferents from the spared eye spread across the thalamus in a manner that is dependent on spontaneous retinal activity. However, how this spontaneous activity, also known as retinal waves, might dynamically
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FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord. Neural. Dev. (IF 2.63) Pub Date : 2018-03-08 Marie-Amélie Farreny,Eric Agius,Sophie Bel-Vialar,Nathalie Escalas,Nagham Khouri-Farah,Chadi Soukkarieh,Cathy Danesin,Fabienne Pituello,Philippe Cochard,Cathy Soula
BACKGROUND Most oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recognized to emerge from dorsal progenitors during fetal development. The prevailing view is that generation of ventral oligodendrocytes depends on Sonic hedgehog (Shh) while dorsal oligodendrocytes
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Transcriptional regulation of ependymal cell maturation within the postnatal brain. Neural. Dev. (IF 2.63) Pub Date : 2018-02-16 Diana Vidovic,Raul Ayala Davila,Richard M Gronostajski,Tracey J Harvey,Michael Piper
BACKGROUND Radial glial stem cells within the developing nervous system generate a variety of post-mitotic cells, including neurons and glial cells, as well as the specialised multi-ciliated cells that line the walls of the ventricular system, the ependymal cells. Ependymal cells separate the brain parenchyma from the cerebrospinal fluid and mediate osmotic regulation, the flow of cerebrospinal fluid
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Correction to: Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex. Neural. Dev. (IF 2.63) Pub Date : 2018-01-11 Olivier Clément,Isabel Anne Hemming,Ivan Enghian Gladwyn-Ng,Zhengdong Qu,Shan Shan Li,Michael Piper,Julian Ik-Tsen Heng
After publication of the original article [1] it was realised that there were errors in figures 2a,b,f,g, which arose as a result of preparing figures from data collected and analysed at the same time as the work reported in [2] (Supplementary Figure 1 of [2]). An updated Fig. 2 is included with this Correction.
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Anisotropic Müller glial scaffolding supports a multiplex lattice mosaic of photoreceptors in zebrafish retina. Neural. Dev. (IF 2.63) Pub Date : 2017-11-15 Mikiko Nagashima,Jeremy Hadidjojo,Linda K Barthel,David K Lubensky,Pamela A Raymond
BACKGROUND The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely defined neighbor relationships among different cone types. Cellular mechanisms patterning this multiplex mosaic are not understood. Physical models can provide new insights into fundamental
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Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes. Neural. Dev. (IF 2.63) Pub Date : 2017-11-15 Geeta Godbole,Achira Roy,Ashwin S Shetty,Shubha Tole
Patterning of the telencephalic neuroepithelium is a tightly regulated process controlled by transcription factors and signalling molecules. The cortical primordium is flanked by two signalling centres, the hem medially, and the antihem laterally. The hem induces the formation of the hippocampus in adjacent neuroepithelium. Therefore, the position of the hem defines the position of the hippocampus
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Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish. Neural. Dev. (IF 2.63) Pub Date : 2017-10-11 Xin Shao,Vanisha Lakhina,Puneet Dang,Ryan P Cheng,Christina L Marcaccio,Jonathan A Raper
BACKGROUND The axons of Olfactory Sensory Neurons (OSNs) project to reproducible target locations within the Olfactory Bulb (OB), converting odorant experience into a spatial map of neural activity. We characterized the initial targeting of OSN axons in the zebrafish, a model system suitable for studying axonal targeting early in development. In this system the initial targets of OSN axons are a small
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Cell type-specific effects of p27KIP1 loss on retinal development. Neural. Dev. (IF 2.63) Pub Date : 2017-09-20 Mariko Ogawa,Fuminori Saitoh,Norihiro Sudou,Fumi Sato,Hiroki Fujieda
BACKGROUND Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, cell cycle exit and cell differentiation. p27KIP1 (p27), one of the major CDK inhibitors in the retina, has been shown to control the timing of cell cycle exit of retinal progenitors. However, the precise role of this protein in retinal development remains largely unexplored. We thus analyzed
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Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina. Neural. Dev. (IF 2.63) Pub Date : 2017-09-01 Nathalie Bessodes,Karine Parain,Odile Bronchain,Eric J Bellefroid,Muriel Perron
BACKGROUND Amacrine interneurons that modulate synaptic plasticity between bipolar and ganglion cells constitute the most diverse cell type in the retina. Most are inhibitory neurons using either GABA or glycine as neurotransmitters. Although several transcription factors involved in amacrine cell fate determination have been identified, mechanisms underlying amacrine cell subtype specification remain
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Two Drosophila model neurons can regenerate axons from the stump or from a converted dendrite, with feedback between the two sites. Neural. Dev. (IF 2.63) Pub Date : 2017-08-17 Kavitha S Rao,Melissa M Rolls
BACKGROUND After axon severing, neurons recover function by reinitiating axon outgrowth. New outgrowth often originates from the remaining axon stump. However, in many mammalian neurons, new axons initiate from a dendritic site when the axon is injured close to the cell body. METHODS Drosophila sensory neurons are ideal for studying neuronal injury responses because they can be injured reproducibly
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Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2. Neural. Dev. (IF 2.63) Pub Date : 2017-08-18 Shenyue Qin,Stephanie M Ware,Ronald R Waclaw,Kenneth Campbell
BACKGROUND Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer