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  • COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis
    Rev. Neurosci. (IF 3.358) Pub Date : 2021-01-12
    Saber Soltani; Alireza Tabibzadeh; Armin Zakeri; Amir Mohammad Zakeri; Tayebeh Latifi; Mahdi Shabani; Amir Pouremamali; Yousef Erfani; Iraj Pakzad; Pooneh Malekifar; Reza Valizadeh; Milad Zandi; Reza Pakzad

    The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2021-01-11

    Journal Name: Reviews in the Neurosciences Volume: 32 Issue: 1 Pages: i-iii

  • A BRD’s (BiRD’s) eye view of BET and BRPF bromodomains in neurological diseases
    Rev. Neurosci. (IF 3.358) Pub Date : 2021-01-05
    Harish Iyer; Abhipradnya B. Wahul; Annapoorna P. K.; Bharvi S. Sawant; Arvind Kumar

    Neurological disorders (NLDs) are among the top leading causes for disability worldwide. Dramatic changes in the epigenetic topography of the brain and nervous system have been found in many NLDs. Histone lysine acetylation has prevailed as one of the well characterised epigenetic modifications in these diseases. Two instrumental components of the acetylation machinery are the evolutionarily conserved

  • The role of prolactin in central nervous system inflammation
    Rev. Neurosci. (IF 3.358) Pub Date : 2021-01-01
    Edgar Ramos-Martinez; Ivan Ramos-Martínez; Gladys Molina-Salinas; Wendy A. Zepeda-Ruiz; Marco Cerbon

    Prolactin has been shown to favor both the activation and suppression of the microglia and astrocytes, as well as the release of inflammatory and anti-inflammatory cytokines. Prolactin has also been associated with neuronal damage in diseases such as multiple sclerosis, epilepsy, and in experimental models of these diseases. However, studies show that prolactin has neuroprotective effects in conditions

  • COVID–19 infection and stroke risk
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-23
    Shaghayegh Sadeghmousavi; Nima Rezaei

    Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan city, China in December 2019 and rapidly spread to other countries. The most common reported symptoms are fever, dry cough, myalgia and fatigue, headache, anorexia, and breathlessness. Anosmia and dysgeusia as well as gastrointestinal symptoms including nausea and diarrhea

  • Recent advances in the noninvasive detection of high-frequency oscillations in the human brain
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-25
    Yuying Fan; Liping Dong; Xueyan Liu; Hua Wang; Yunhui Liu

    In recent decades, a significant body of evidence based on invasive clinical research has showed that high-frequency oscillations (HFOs) are a promising biomarker for localization of the seizure onset zone (SOZ), and therefore, have the potential to improve postsurgical outcomes in patients with epilepsy. Emerging clinical literature has demonstrated that HFOs can be recorded noninvasively using methods

  • Depression following traumatic brain injury: a comprehensive overview
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-23
    Marc Fakhoury; Zaynab Shakkour; Firas Kobeissy; Nada Lawand

    Traumatic brain injury (TBI) represents a major health concern affecting the neuropsychological health; TBI is accompanied by drastic long-term adverse complications that can influence many aspects of the life of affected individuals. A substantial number of studies have shown that mood disorders, particularly depression, are the most frequent complications encountered in individuals with TBI. Post-traumatic

  • Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-18
    Graham Ka Hon Shea; Paul Aarne Koljonen; Ying Shing Chan; Kenneth Man Chee Cheung

    Degenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological

  • The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-07
    César Espino De la Fuente-Muñoz; Clorinda Arias

    Mitochondrial activity is essential to support neural functions, and changes in the integrity and activity of the mitochondria can contribute to synaptic damage and neuronal death, especially in degenerative diseases associated with age, such as Alzheimer’s and Parkinson’s disease. Currently, different approaches are used to treat these conditions, and one strategy under research is mitochondrial transplantation

  • CNS implications of COVID-19: a comprehensive review
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-07
    Priyanka Nagu; Arun Parashar; Tapan Behl; Vineet Mehta

    COVID-19 was first reported in December 2019 in the Wuhan city of China, and since then it has spread worldwide taking a heavy toll on human life and economy. COVID-19 infection is commonly associated with symptoms like coughing, fever, and shortness of breath, besides, the reports of muscle pain, anosmia, hyposmia, and loss of taste are becoming evident. Recent reports suggest the pathogenic invasion

  • Early life stress and brain plasticity: from molecular alterations to aberrant memory and behavior
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-12-04
    Olga L. Lopatina; Yulia A. Panina; Natalia A. Malinovskaya; Alla B. Salmina

    Early life stress (ELS) is one of the most critical factors that could modify brain plasticity, memory and learning abilities, behavioral reactions, and emotional response in adulthood leading to development of different mental disorders. Prenatal and early postnatal periods appear to be the most sensitive periods of brain development in mammals, thereby action of various factors at these stages of

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-11-25

    Journal Name: Reviews in the Neurosciences Volume: 31 Issue: 8 Pages: i-iii

  • The subiculum and its role in focal epileptic disorders
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-11-30
    Maxime Lévesque; Massimo Avoli

    The subicular complex (hereafter referred as subiculum), which is reciprocally connected with the hippocampus and rhinal cortices, exerts a major control on hippocampal outputs. Over the last three decades, several studies have revealed that the subiculum plays a pivotal role in learning and memory but also in pathological conditions such as mesial temporal lobe epilepsy (MTLE). Indeed, subicular networks

  • COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-11-12
    Milena de Barros Viana; Bárbara dos Anjos Rosário; Maria de Fátima Santana de Nazaré; Débora Estadella; Daniel Araki Ribeiro; Glauce Socorro de Barros Viana

    The coronavirus disease (COVID-19), identified in Wuhan, China, on December 2019, was declared a pandemic by the World Health Organization, on March, 2020. Since then, efforts have been gathered to describe its clinical course and to determine preventive measures and treatment strategies. Adults older than 65 years of age are more susceptible to serious clinical symptoms and present higher mortality

  • Genetic parkinsonisms and cancer: a systematic review and meta-analysis
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-11-05
    Andrea Sturchio; Alok K. Dwivedi; Joaquin A. Vizcarra; Martina Chirra; Elizabeth G. Keeling; Ignacio F. Mata; Marcelo A. Kauffman; Manoj K. Pandey; Giandomenico Roviello; Cristoforo Comi; Maurizio Versino; Luca Marsili; Alberto J. Espay

    Genes associated with parkinsonism may also be implicated in carcinogenesis, but their interplay remains unclear. We systematically reviewed studies (PubMed 1967–2019) reporting gene variants associated with both parkinsonism and cancer. Somatic variants were examined in cancer samples, whereas germline variants were examined in cancer patients with both symptomatic and asymptomatic (carriers) genetic

  • VEGF levels in patients with glioma: a systematic review and meta-analysis
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-11-02
    Homa Seyedmirzaei; Parnian Shobeiri; Mehmet Turgut; Sara Hanaei; Nima Rezaei

    Vascular endothelial growth factor (VEGF) has a crucial role in the angiogenesis of various tumors, including glioma. As the levels of VEGF would change in patients with glioma, we conducted the current systematic review and meta-analysis to more clearly determine the VEGF level alterations in different grades of glioma. PubMed and Scopus databases were sensitively searched for all the possible keywords

  • The basal ganglia corticostriatal loops and conditional learning
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-10-28
    Keyvan Yahya

    Brief maneuvering of the literature as to the various roles attributed to the basal ganglia corticostriatal circuits in a variety of cognitive processes such as working memory, selective attention, and category learning has inspired us to investigate the interplay of the two major basal ganglia open-recurrent loops, namely, visual and executive loops specifically the possible involvement of their overlap

  • Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-10-26
    Brian Fiani; Juliana Runnels; Ashley Taylor; Manraj Sekhon; Daniel Chacon; Michael McLarnon; Rebecca Houston; Sasha Vereecken

    Spinal injury is among the most severe and feared injuries an athlete may face. We present an up-to-date review of the recent literature, stratifying recommendations based on injury location (cervical, thoracic, and lumbar spine) and type, as well as, the level of competitive play (high school, collegiate, professional). A literature search was completed to identify all publications reporting return

  • A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-10-19
    Kajal Rawat; Neha Singh; Puja Kumari; Lekha Saha

    The gut microbiota plays an important role in neurological diseases via the gut–brain axis. Many factors such as diet, antibiotic therapy, stress, metabolism, age, geography and genetics are known to play a critical role in regulating the colonization pattern of the microbiota. Recent studies have shown the role of the low carbohydrate, adequate protein, and high fat “ketogenic diet” in remodeling

  • Detection of disease-associated microRNAs -application for autism spectrum disorders.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-19
    Barbora Konečná,Jana Radošinská,Petra Keményová,Gabriela Repiská

    Autism spectrum disorders (ASD) diagnostic procedure still lacks a uniform biological marker. This review gathers the information on microRNAs (miRNAs) specifically as a possible source of biomarkers of ASD. Extracellular vesicles, and their subset of exosomes, are believed to be a tool of cell-to-cell communication, and they are increasingly considered to be carriers of such a marker. The interest

  • Depression in post-traumatic stress disorder.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-31
    Milen L Radell,Eid Abo Hamza,Ahmed A Moustafa

    Major depressive disorder (MDD) symptoms commonly occur after trauma-exposure, both alone and in combination with post-traumatic stress disorder (PTSD). This article reviews recent research on comorbidity between these disorders, including its implications for symptom severity and response to treatment. Despite considerable symptom overlap, the two disorders represent distinct constructs and depend

  • Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19).
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-10
    Niloufar Yazdanpanah,Amene Saghazadeh,Nima Rezaei

    Just before 2020 began, a novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), brought for humans a potentially fatal disease known as coronavirus disease 2019 (COVID-19). The world has thoroughly been affected by COVID-19, while there has been little progress towards understanding the pathogenesis of COVID-19. Patients with a severe phenotype of disease and those who died

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-10-02

    Journal Name: Reviews in the Neurosciences Volume: 31 Issue: 7 Pages: i-iii

  • The role of melatonin and its analogues in epilepsy.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-22
    Sumaira Khan,Mallika Khurana,Preeti Vyas,Divya Vohora

    Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting the association of the melatonergic ligands with epilepsy have also emerged. In this context, our review

  • Efficacy and safety of endovascular treatment for patients with acute intracranial atherosclerosis-related posterior circulation stroke: a systematic review and meta-analysis.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-15
    Jiajia Bao,Ye Hong,Chaohua Cui,Mengmeng Ma,Lijie Gao,Qian Liu,Ning Chen,Li He

    The benefit of endovascular treatment (EVT) for patients with intracranial atherosclerosis–related large vessel occlusion (ICAS-LVO) in posterior circulation stroke (PCS) is inconsistent. This systematic review and meta-analysis were conducted to estimate the effect of ICAS-LVO in PCS treated by EVT. A systematic review was completed, tracking studies from their date of inception until February 2020

  • Resveratrol in the treatment of neuroblastoma: a review.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-13
    Kamil Leis,Aleksandra Baska,Weronika Bereźnicka,Agata Marjańska,Ewelina Mazur,Bartosz Tadeusz Lewandowski,Krystian Kałużny,Przemysław Gałązka

    Resveratrol, polyphenol naturally occurring in grapes or nuts, has anti-cancer properties in the treatment of neuroblastoma – the most common childhood solid tumor. It affects cancer cells by increasing apoptosis, inducing cell necrosis and reducing tumor mass. Mechanism of action – (1) converting procaspases, mainly procaspases three and nine into active forms – caspases, (2) blocking kinases, and

  • Treatment for mitochondrial diseases.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-09
    Tongling Liufu,Zhaoxia Wang

    Mitochondrial diseases are predominantly caused by mutations of mitochondrial or nuclear DNA, resulting in multisystem defects. Current treatments are largely supportive, and the disorders progress relentlessly. Nutritional supplements, pharmacological agents and physical therapies have been used in different clinical trials, but the efficacy of these interventions need to be further evaluated. Several

  • BDNF and nicotine dependence: associations and potential mechanisms.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-04
    Zeyi Huang,Daichao Wu,Xilin Qu,Meixiang Li,Ju Zou,Sijie Tan

    Smoking is the leading preventable cause of death worldwide and tobacco addiction has become a serious public health problem. Nicotine is the main addictive component of tobacco, and the majority of people that smoke regularly develop nicotine dependence. Nicotine addiction is deemed to be a chronic mental disorder. Although it is well known that nicotine binds to the nicotinic acetylcholine receptors

  • Gut microbiota on gender bias in autism spectrum disorder.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-09-04
    Xia Hao,Jiao Pan,Xiumei Gao,Shiyu Zhang,Yue Li

    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Its three core symptoms are social communication disorder, communication disorder, narrow interest and stereotyped repetitive behavior. The proportion of male and female autistic patients is 4:1. Many researchers have studied this phenomenon, but the mechanism is still unclear. This review mainly discusses the related mechanism

  • Neuroprotection of hypoxic/ischemic preconditioning in neonatal brain with hypoxic-ischemic injury.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-31
    Xue Fan,Huiqing Wang,Li Zhang,Jun Tang,Yi Qu,Dezhi Mu

    The neonatal brain is susceptible to hypoxic-ischemic injury due to its developmental characteristics. Hypoxia-ischemia means a decreased perfusion of oxygen and glucose, which can lead to severe encephalopathy. Although early initiation of therapeutic hypothermia was reported to provide neuroprotection for infants after HI, hypothermia administered alone after the acute insult cannot reverse the severe

  • Brain metabolic DNA: recent evidence for a mitochondrial connection.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-31
    Antonio Giuditta,Gigliola Grassi Zucconi,Adolfo Sadile

    This review highlights recent data concerning the synthesis of brain metabolic DNA (BMD) by cytoplasmic reverse transcription and the prompt acquisition of the double-stranded configuration that allows its partial transfer to nuclei. BMD prevails in the mitochondrial fraction and is present in presynaptic regions and astroglial processes where it undergoes a turnover lasting a few weeks. Additional

  • Machine learning (ML) for the diagnosis of autism spectrum disorder (ASD) using brain imaging.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-31
    Hidir Selcuk Nogay,Hojjat Adeli

    Autism spectrum disorder (ASD) is a neurodevelopmental incurable disorder with a long diagnostic period encountered in the early years of life. If diagnosed early, the negative effects of this disease can be reduced by starting special education early. Machine learning (ML), an increasingly ubiquitous technology, can be applied for the early diagnosis of ASD. The aim of this study is to examine and

  • Noninvasive brain stimulation for patients with a disorder of consciousness: a systematic review and meta-analysis.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-27
    Yali Feng,Jiaqi Zhang,Yi Zhou,Zhongfei Bai,Ying Yin

    Noninvasive brain stimulation (NIBS) techniques have been used to facilitate the recovery from prolonged unconsciousness as a result of brain injury. The aim of this study is to systematically assess the effects of NIBS in patients with a disorder of consciousness (DOC). We searched four databases for any randomized controlled trials on the effect of NIBS in patients with a DOC, which used the JFK

  • Channels to consciousness: a possible role of gap junctions in consciousness.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-27
    Dorothea Dere,Armin Zlomuzica,Ekrem Dere

    The neurophysiological basis of consciousness is still unknown and one of the most challenging questions in the field of neuroscience and related disciplines. We propose that consciousness is characterized by the maintenance of mental representations of internal and external stimuli for the execution of cognitive operations. Consciousness cannot exist without working memory, and it is likely that consciousness

  • Retinal involvement in Alzheimer's disease (AD): evidence and current progress on the non-invasive diagnosis and monitoring of AD-related pathology using the eye.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-17
    Fidelis Chibhabha,Yang Yaqi,Feng Li

    Alzheimer's disease (AD) is a common form of age-related dementia that mostly affects the aging population. Clinically, it is a disease characterized by impaired memory and progressive cognitive decline. Although the pathological hallmarks of AD have been traditionally described with a general confinement in the brain, recent studies have shown similar pathological changes in the retina, which is a

  • Lifestyle intervention to prevent Alzheimer's disease.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-17
    Yi Ko,Soi Moi Chye

    Alzheimer’s disease (AD) is the most common neurodegenerative disease that leads to significant morbidities in elderly. The major pathological hallmark of AD is beta-amyloid plaques (Aβ) and intracellular neurofibrillary tangles (NFTs) deposition in hippocampus of the brain. These abnormal protein deposition damages neuronal cells resulting in neurodegeneration and cognitive decline. As a result of

  • A bigger brain for a more complex environment.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-17
    Umberto di Porzio

    The environment increased complexity required more neural functions to develop in the hominin brains, and the hominins adapted to the complexity by developing a bigger brain with a greater interconnection between its parts. Thus, complex environments drove the growth of the brain. In about two million years during hominin evolution, the brain increased three folds in size, one of the largest and most

  • A new method to predict anomaly in brain network based on graph deep learning.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-17
    Jalal Mirakhorli,Hamidreza Amindavar,Mojgan Mirakhorli

    Functional magnetic resonance imaging a neuroimaging technique which is used in brain disorders and dysfunction studies, has been improved in recent years by mapping the topology of the brain connections, named connectopic mapping. Based on the fact that healthy and unhealthy brain regions and functions differ slightly, studying the complex topology of the functional and structural networks in the

  • The potential anti-depressant properties of dexmedetomidine infusion: a review of mechanistic, preclinical, and clinical evidence.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-06-24
    Mohammed Al-Alawi,Elisa Brietzke,Adriana Carvalhal,Claudio N Soares

    Major depressive disorder (MDD) is a highly prevalent and disabling condition for which the currently available treatments are not fully effective. Existing unmet needs include rapid onset of action and optimal management of concurrent agitation. Dexmedetomidine (DEX) is a selective and potent α2-adrenergic receptor (α2-AR) agonist, with unique pharmacokinetic and pharmacodynamic properties. In this

  • Neurophysiologic implications of neuronal nitric oxide synthase.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-03
    Masoumeh Kourosh-Arami,Nasrin Hosseini,Monireh Mohsenzadegan,Alireza Komaki,Mohammad Taghi Joghataei

    The molecular and chemical properties of neuronal nitric oxide synthase (nNOS) have made it a key mediator in many physiological functions and signaling transduction. The NOS monomer is inactive, but the dimer form is active. There are three forms of NOS, which are neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) nitric oxide synthase. nNOS regulates nitric oxide (NO) synthesis which is the

  • Cochlear synaptopathy: new findings in animal and human research.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-20
    Cristian Aedo,Enzo Aguilar

    In animal models, prolonged exposure (2 h) to high-level noise causes an irreparable damage to the synapses between the inner hair cells and auditory nerve fibers within the cochlea. Nevertheless, this injury does not necessarily alter the hearing threshold. Similar findings have been observed as part of typical aging in animals. This type of cochlear synaptopathy, popularly called “hidden hearing

  • GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-03
    Susanne Nikolaus,Markus Beu,Hans-Jörg Wittsack,Anja Müller-Lutz,Christina Antke,Hubertus Hautzel,Yuriko Mori,Eduards Mamlins,Gerald Antoch,Hans-Wilhelm Müller

    In this review, a series of experiments is presented, in which γ-amino butyric acid (GABA)ergic and glutamatergic effects on dopamine function in the rat nigrostriatal and mesolimbic system was systematically assessed after pharmacological challenge with GABAA receptor (R) and and N-methyl d-aspartate (NMDA)R agonists and antagonists. In these studies, [123I]iodobenzamide binding to the D2/3R was mesured

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-13

    Journal Name: Reviews in the Neurosciences Volume: 31 Issue: 6 Pages: i-iii

  • Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-08-10
    Hamidreza Arzaghi,Bashir Adel,Hossein Jafari,Shaghayegh Askarian-Amiri,Amin Shiralizadeh Dezfuli,Abolfazl Akbarzadeh,Hamidreza Pazoki-Toroudi

    The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However

  • Training the brain: could it improve multiple sclerosis treatment?
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-27
    Berenice Anabel Silva,Esteban Alberto Miglietta,Carina Cintia Ferrari

    Multiple sclerosis (MS) is a neurological disease characterized by neuroinflammation, demyelination and axonal degeneration along with loss of function in the central nervous system. For many years, research in MS has focused on the efficacy of pharmacological treatments. However, during the last years, many publications have been dedicated to the study of the efficacy of non-pharmacological strategies

  • The biological and diagnostic roles of MicroRNAs in meningiomas.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-22
    Lei Wang,Shengpan Chen,Yan Liu,Hongqi Zhang,Nianjun Ren,Ruoyu Ma,Zhengwen He

    MicroRNAs (miRNAs) refer to a class of small endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level. Emerging studies have shown that miRNAs play critical roles in tumorigenesis and cancer progression. However, roles and mechanisms of miRNA dysregulation in the pathogenesis of meningioma are not fully understood. Here, we first reviewed existing research of aberrantly

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-17

    Journal Name: Reviews in the Neurosciences Volume: 31 Issue: 5 Pages: i-iii

  • The role of exosome lipids in central nervous system diseases.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-18
    Ge Wang,Yong Wang,Ningyuan Liu,Mujun Liu

    Central nervous system (CNS) diseases are common diseases that threaten human health. The CNS is highly enriched in lipids, which play important roles in maintaining normal physiological functions of the nervous system. Moreover, many CNS diseases are closely associated with abnormal lipid metabolism. Exosomes are a subtype of extracellular vesicles (EVs) secreted from multivesicular bodies (MVBs)

  • The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-17
    Tommaso Schirinzi,Marco Canevelli,Antonio Suppa,Matteo Bologna,Luca Marsili

    While the “physiological” aging process is associated with declines in motor and cognitive features, these changes do not significantly impair functions and activities of daily living. Differently, motor and cognitive impairment constitute the most common phenotypic expressions of neurodegeneration. Both manifestations frequently coexist in the same disease, thus making difficult to detect “pure” motor

  • Treatment strategies for encephalopathy related to status epilepticus during slow sleep, a narrative review of the literature.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-07-17
    Ke Zhang,Yu Yan,Tangfeng Su

    Encephalopathy related to Status Epilepticus during slow Sleep (ESES) is an age-dependent syndrome characterized by the appearance of neuropsychological and behavioral disorders associated with extreme activation of epileptic activity during sleep. The major goal of therapy in ESES is to prevent neuropsychological deficits. Effective therapy to reduce seizures and resolve the EEG pattern of status

  • Frontmatter
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-05-26

    Journal Name: Reviews in the Neurosciences Volume: 31 Issue: 4 Pages: i-iii

  • The involvement of the central nervous system in patients with COVID-19.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-05-26
    Kiarash Saleki,Mohammad Banazadeh,Amene Saghazadeh,Nima Rezaei

    Coronaviruses disease (COVID-19) has caused major outbreaks. A novel variant, SARS-CoV-2, is responsible for COVID-19 pandemic. Clinical presentations and pathological mechanisms of COVID-19 are broad. The respiratory aspect of the disease has been extensively researched. Emerging studies point out the possibility of the central nervous system (CNS) involvement by COVID-19. Here, we discuss the current

  • Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-05-15
    Alessandro Ricci,Maia A Idzikowski,Claudio N Soares,Elisa Brietzke

    The ketogenic diet (KD) is characterized by a diet ratio of 4:1 fat to non-fat energy sources. For decades KD has been successfully used to control seizures in epilepsy patients. Investigations into its mechanism of action suggest that it may have an effect on the metabolic, nervous, immune, and digestive systems. In this review, we postulate that KD may also improve depressive symptoms – for that

  • The neurophysiology of ketamine: an integrative review.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-05-05
    Rebecca McMillan,Suresh D Muthukumaraswamy

    The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of psychosis and, most recently, its antidepressant properties. Understanding the physiology of ketamine is complex due to its rich pharmacology with multiple potential sites at clinically relevant doses. In this review of the neurophysiology of ketamine, we focus on the acute effects of ketamine in the resting

  • Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-05-04
    Asiamah Ernest Amponsah,Baofeng Feng,Ruiyun Guo,Wei Zhang,Jingjing He,Desheng Kong,Tianyu Dong,Jun Ma,Huixian Cui

    Alzheimer's disease (AD) is a very common cause of dementia in the elderly. It is characterized by progressive amnesia and accretions of neurofibrillary tangles (NFTs) of neurons and senile plaques in the neuropil. After aging, the inheritance of the apolipoprotein E (ApoE) epsilon 4 (ε4) allele is the greatest risk factor for late-onset AD. The ApoE protein is the translated product of the ApoE gene

  • A review on the alterations in the brain of persistent postural-perceptual dizziness patients and non-pharmacological interventions for its management.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-04-13
    Li Sun,Ke Xiang

    Persistent postural perceptual dizziness (PPPD) is a relatively newer term, and this term is included in the International Classification of Diseases in its 11th revision. The typical features of PPPD include the presence of persistent dizziness, non-spinning vertigo, and unsteadiness, and these symptoms are exacerbated during upright posture, movement, or visual stimuli. Moreover, the structural changes

  • Perisaccadic remapping: What? How? Why?
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-04-02
    Sujaya Neupane,Daniel Guitton,Christopher C Pack

    About 25 years ago, the discovery of receptive field (RF) remapping in the parietal cortex of nonhuman primates revealed that visual RFs, widely assumed to have a fixed retinotopic organization, can change position before every saccade. Measuring such changes can be deceptively difficult. As a result, studies that followed have generated a fascinating but somewhat confusing picture of the phenomenon

  • Role of kinaesthetic motor imagery in mirror-induced visual illusion as intervention in post-stroke rehabilitation.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-03-27
    Umar M Bello,Stanley J Winser,Chetwyn C H Chan

    Mirror-induced visual illusion obtained through mirror therapy is widely used to facilitate motor recovery after stroke. Activation of primary motor cortex (M1) ipsilateral to the moving limb has been reported during mirror-induced visual illusion. However, the mechanism through which the mirror illusion elicits motor execution processes without movements observed in the mirrored limb remains unclear

  • Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-03-03
    Xin Yang

    The chondroitin sulfate proteoglycans (CSPGs) are large groups of heterogenous proteoglycans that are mainly expressed by reactive astrocytes in the central nervous system (CNS). They share similar core proteins and are post-transcriptionally modified by chondroitin sulfate glycosaminoglycans. CSPGs are the major components of the perineuronal nets (PNN) that regulate the opening and closure of the

  • Insights into the neuropathology of cerebral ischemia and its mechanisms.
    Rev. Neurosci. (IF 3.358) Pub Date : 2020-03-03
    Mohamad Anuar Ahad,Kesevan Rajah Kumaran,Tiang Ning,Nur Izzati Mansor,Mohamad Azmeer Effendy,Thenmoly Damodaran,Kamilla Lingam,Habibah Abdul Wahab,Norshariza Nordin,Ping Liao,Christian P Müller,Zurina Hassan

    Cerebral ischemia is a result of insufficient blood flow to the brain. It leads to limited supply of oxygen and other nutrients to meet metabolic demands. These phenomena lead to brain damage. There are two types of cerebral ischemia: focal and global ischemia. This condition has significant impact on patient’s health and health care system requirements. Animal models such as transient occlusion of

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