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Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2021-01-07 Maijke van Bloemendaal; Sicco A. Bus; Frans Nollet; Alexander C. H. Geurts; Anita Beelen
Background. Many stroke survivors suffer from leg muscle paresis, resulting in asymmetrical gait patterns, negatively affecting balance control and energy cost. Interventions targeting asymmetry early after stroke may enhance recovery of walking. Objective. To determine the feasibility and preliminary efficacy of up to 10 weeks of gait training assisted by multichannel functional electrical stimulation
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Development of a Comprehensive Outcome Measure for Motor Coordination, Step 2: Reliability and Construct Validity in Chronic Stroke Patients Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2021-01-07 Roni Molad; Sandra R. Alouche; Marika Demers; Mindy F. Levin
Background A comprehensive scale assessing motor coordination of multiple body segments was developed using a 3-phase content validation process. The Comprehensive Coordination Scale (CCS) evaluates motor coordination defined as the ability to produce context-dependent movements of multiple effectors in both spatial and temporal domains. The scale assesses motor coordination in individuals with neurological
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Predicting Working Memory Training Responsiveness in Parkinson’s Disease: Both “System Hardware” and Room for Improvement Are Needed Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2021-01-07 Anja Ophey; Sarah Rehberg; Kathrin Giehl; Carsten Eggers; Paul Reker; Thilo van Eimeren; Elke Kalbe
Background. Patients with Parkinson’s disease (PD) are highly vulnerable to develop cognitive dysfunctions, and the mitigating potential of early cognitive training (CT) is increasingly recognized. Predictors of CT responsiveness, which could help to tailor interventions individually, have rarely been studied in PD. This study aimed to examine individual characteristics of patients with PD associated
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Canadian Platform for Trials in Noninvasive Brain Stimulation (CanStim) Consensus Recommendations for Repetitive Transcranial Magnetic Stimulation in Upper Extremity Motor Stroke Rehabilitation Trials Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2021-01-07 Jodi D. Edwards; Sandra E. Black; Shaun Boe; Lara Boyd; Arthur Chaves; Robert Chen; Sean Dukelow; Joyce Fung; Adam Kirton; Jed Meltzer; Zahra Moussavi; Jason Neva; Caroline Paquette; Michelle Ploughman; Sepideh Pooyania; Tarek K. Rajji; Marc Roig; Francois Tremblay; Alexander Thiel
Objective. To develop consensus recommendations for the use of repetitive transcranial magnetic stimulation (rTMS) as an adjunct intervention for upper extremity motor recovery in stroke rehabilitation clinical trials. Participants. The Canadian Platform for Trials in Non-Invasive Brain Stimulation (CanStim) convened a multidisciplinary team of clinicians and researchers from institutions across Canada
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Constraint-Induced Movement Therapy Promotes Neural Remodeling and Functional Reorganization by Overcoming Nogo-A/NgR/RhoA/ROCK Signals in Hemiplegic Cerebral Palsy Mice Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2021-01-07 Li-Ru Liu; Yu-Xin Wang; Lu He; Yun-Xian Xu; Jing-Yu Huang; Ting-Ting Peng; Xu-Bo Yang; Jing Pan; Hong-Mei Tang; Kai-Shou Xu
Background. Little is known about the induction of functional and brain structural reorganization in hemiplegic cerebral palsy (HCP) by constraint-induced movement therapy (CIMT). Objective. We aimed to explore the specific molecular mechanism of functional and structural plasticity related to CIMT in HCP. Methods. The mice were divided into a control group and HCP groups with different interventions
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Identifiable Patterns of Trait, State, and Experience in Chronic Stroke Recovery Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-22 E. Susan Duncan; A. Duke Shereen; Thanos Gentimis; Steven L. Small
Background Considerable evidence indicates that the functional connectome of the healthy human brain is highly stable, analogous to a fingerprint. Objective We investigated the stability of functional connectivity across tasks and sessions in a cohort of individuals with chronic stroke using a supervised machine learning approach. Methods Twelve individuals with chronic stroke underwent functional
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Development of a Comprehensive Outcome Measure for Motor Coordination; Step 1: Three-Phase Content Validity Process Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-22 Sandra R. Alouche; Roni Molad; Marika Demers; Mindy F. Levin
Background Motor coordination, the ability to produce context-dependent organized movements in spatial and temporal domains, is impaired after neurological injuries. Outcome measures assessing coordination mostly quantify endpoint performance variables (ie, temporal qualities of whole arm movement) but not movement quality (ie, trunk and arm joint displacements). Objective To develop an outcome measure
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Secreted Peptides for Diagnostic Trajectory Assessments in Brain Injury Rehabilitation Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-17 Parantap D. Patel; Jillian E. Stafflinger; Jennifer H. Marwitz; Janet P. Niemeier; Andrew K. Ottens
Background Rehabilitation following traumatic brain injury (TBI) significantly improves outcomes; yet TBI heterogeneity raises the need for molecular evidence of brain recovery processes to better track patient progress, evaluate therapeutic efficacy, and provide prognostication. Objective Here, we assessed whether the trajectory of TBI-responsive peptides secreted into urine can produce a predictive
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White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-14 Yi Zhao; Bronte Ficek; Kimberly Webster; Constantine Frangakis; Brian Caffo; Argye E. Hillis; Andreia Faria; Kyrana Tsapkini
Background Transcranial direct current stimulation (tDCS), in conjunction with language therapy, improves language therapy outcomes in primary progressive aphasia (PPA). However, no studies show whether white matter integrity predicts language therapy or tDCS effects in PPA. Objective We aimed to determine whether white matter integrity, measured by diffusion tensor imaging (DTI), predicts written
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Intermittent Skill Training Results in Moderate Improvement in Functional Outcome in a Mouse Model of Ischemic Stroke Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-14 Victoria Nemchek; Emma M. Haan; Abigail L. Kerr
Background Stroke is a leading cause of disability worldwide. Focused training of the impaired limb has been shown to improve its functional outcome in animal models. However, most human stroke survivors exhibit persistent motor deficits, likely due to differences in rehabilitation intensity between experimental (animal) and clinical (human) settings. Objective The current study investigated the effect
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Statistical Considerations for Drawing Conclusions About Recovery Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-12-14 Keith R. Lohse; Rachel L. Hawe; Sean P. Dukelow; Stephen H. Scott
Background Numerous studies have found associations when change scores are regressed onto initial impairments in people with stroke (slopes ≈ 0.7). However, there are important statistical considerations that limit the conclusions we can draw about recovery from these studies. Objective To provide an accessible checklist of conceptual and analytical issues on longitudinal measures of stroke recovery
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Five Features to Look for in Early-Phase Clinical Intervention Studies Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-26 Jonathan S. Tsay; Carolee J. Winstein
Neurorehabilitation relies on core principles of neuroplasticity to activate and engage latent neural connections, promote detour circuits, and reverse impairments. Clinical interventions incorporating these principles have been shown to promote recovery and demote compensation. However, many clinicians struggle to find interventions centered on these principles in our nascent, rapidly growing body
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Prolonged Standing Task Affects Adaptability of Postural Control in People With Parkinson’s Disease Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-26 Gabriel Felipe Moretto; Felipe Balistieri Santinelli; Tiago Penedo; Luis Mochizuki; Natalia Madalena Rinaldi; Fabio Augusto Barbieri
Background Studies on short-term upright quiet standing tasks have presented contradictory findings about postural control in people with Parkinson’s disease (pwPD). Prolonged trial durations might better depict body sway and discriminate pwPD and controls. Objective The aim of this study was to investigate postural control in pwPD during a prolonged standing task. Methods A total of 26 pwPD and 25
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Accuracy of the Upper Limb Prediction Algorithm PREP2 Applied 2 Weeks Poststroke: A Prospective Longitudinal Study Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-20 Camilla Biering Lundquist; Jørgen Feldbæk Nielsen; Federico Gabriel Arguissain; Iris Charlotte Brunner
Background The Predict Recovery Potential algorithm (PREP2) was developed to predict upper limb (UL) function early after stroke. However, assessment in the acute phase is not always possible. Objective To assess the prognostic accuracy of the PREP2 when applied in a subacute neurorehabilitation setting. Methods This prospective longitudinal study included patients ≥18 years old with UL impairment
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Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-16 Jung-Hee Jang; Sangsoo Park; Jinung An; Jong-duk Choi; In chan Seol; Gunhyuk Park; Seung Hyun Lee; Young Moon; Weechang Kang; Eun-Sun Jung; Ji-yun Cha; Chan-young Kim; Siyeon Kim; In Chul Jung; Horyong Yoo
Background Parkinson’s disease (PD) leads to impaired mobility and limited independence. Objective We investigated the effects of acupuncture on gait disturbance and analyzed hemodynamic changes caused by acupuncture in the cerebral cortex of patients with PD. Methods Participants (n = 26) with gait disturbance due to PD were randomly assigned to the intervention (acupuncture twice a week for 4 weeks
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Multimodal Neuroimaging Using Concurrent EEG/fNIRS for Poststroke Recovery Assessment: An Exploratory Study Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-16 Rihui Li; Sheng Li; Jinsook Roh; Chushan Wang; Yingchun Zhang
Background Persistent motor deficits are very common in poststroke survivors and often lead to disability. Current clinical measures for profiling motor impairment and assessing poststroke recovery are largely subjective and lack precision. Objective A multimodal neuroimaging approach was developed based on concurrent functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) to
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Telerehabilitation After Stroke Using Readily Available Technology: A Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-16 Nicola L. Saywell; Alain C. Vandal; Suzie Mudge; Leigh Hale; Paul Brown; Valery Feigin; Carl Hanger; Denise Taylor
Background The number of people living with stroke has increased demand for rehabilitation. A potential solution is telerehabilitation for health care delivery to promote self-management. One such approach is the Augmented Community Telerehabilitation Intervention (ACTIV). This structured 6-month program uses limited face-to-face sessions, telephone contact, and text messages to augment stroke rehabilitation
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Predictive Value of Midsagittal Tissue Bridges on Functional Recovery After Spinal Cord Injury Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-16 Dario Pfyffer; Kevin Vallotton; Armin Curt; Patrick Freund
Background The majority of patients with spinal cord injury (SCI) have anatomically incomplete lesions and present with preserved tissue bridges, yet their outcomes vary. Objective To assess the predictive value of the anatomical location (ventral/dorsal) and width of preserved midsagittal tissue bridges for American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade conversion and SCI patient
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Movement Quality: A Novel Biomarker Based on Principles of Neuroscience Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-13 Stanislaw Solnik; Mariusz P. Furmanek; Daniele Piscitelli
A major problem in neurorehabilitation is the lack of objective outcomes to measure movement quality. Movement quality features, such as coordination and stability, are essential for everyday motor actions. These features allow reacting to continuously changing environment or to resist external perturbations. Neurological disorders affect movement quality, leading to functionally impaired movements
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Cerebellar Theta-Burst Stimulation Combined With Physiotherapy in Subacute and Chronic Stroke Patients: A Pilot Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-09 Ling-Yi Liao; Yun-Juan Xie; Yi Chen; Qiang Gao
Background Intermittent theta-burst stimulation (iTBS) has been suggested to improve poststroke rehabilitation. The cerebellum is considered crucial for motor control. However, the effects of cerebellar iTBS with routine physical therapy on balance and motor recovery in subacute and chronic stroke patients have not been explored. Objective To measure the short-term effects of cerebellar iTBS with physiotherapy
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Executive Control of Walking in People With Parkinson’s Disease With Freezing of Gait Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-06 Rodrigo Vitorio; Samuel Stuart; Martina Mancini
Background Walking abnormalities in people with Parkinson’s disease (PD) are characterized by a shift in locomotor control from healthy automaticity to compensatory prefrontal executive control. Indirect measures of automaticity of walking (eg, step-to-step variability and dual-task cost) suggest that freezing of gait (FoG) may be associated with reduced automaticity of walking. However, the influence
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People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-06 Paulo H. S. Pelicioni; Stephen R. Lord; Yoshiro Okubo; Daina L. Sturnieks; Jasmine C. Menant
Background People with Parkinson’s disease (PD) have difficulties generating quick and accurate steps in anticipation of and/or in response to environmental hazards. However, neural mechanisms underlying performance in cognitively demanding stepping tasks are unclear. Objective This study compared activation patterns in cognitive and motor cortical regions using functional near-infrared spectroscopy
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The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-05 George D. Fulk; Pierce Boyne; Makenzie Hauger; Raktim Ghosh; Samantha Romano; Jonathan Thomas; Amy Slutzky; Karen Klingman
Background Adequate sleep is vital for health and quality of life. People with stroke and a concomitant sleep disorder may have poorer outcomes than those without a sleep disorder. Objective To systematically evaluate the published literature to determine the impact of sleep disorders on physical, functional recovery at the activity and participation level after stroke. Methods A systematic review
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Improving Accelerometry-Based Measurement of Functional Use of the Upper Extremity After Stroke: Machine Learning Versus Counts Threshold Method Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-05 Peter S. Lum; Liqi Shu; Elaine M. Bochniewicz; Tan Tran; Lin-Ching Chang; Jessica Barth; Alexander W. Dromerick
Background Wrist-worn accelerometry provides objective monitoring of upper-extremity functional use, such as reaching tasks, but also detects nonfunctional movements, leading to ambiguity in monitoring results. Objective Compare machine learning algorithms with standard methods (counts ratio) to improve accuracy in detecting functional activity. Methods Healthy controls and individuals with stroke
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Agrin Involvement in Synaptogenesis Induced by Exercise in a Rat Model of Experimental Stroke Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-11-02 Pengyue Zhang; Liqiang Yang; Guangxiang Li; Yaju Jin; Danli Wu; Qing Mei Wang; Peidong Huang
Background Agrin is a proteoglycan that aggregates nicotinic acetylcholine receptors (AChRs) on neuromuscular junctions and takes part in synaptogenesis in the development of the central nervous system. However, its effects on neural repair and synaptogenesis after stroke are still unclear. Objective This study aimed to investigate the effects of agrin on neural repair and synaptogenesis after stroke
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Gains Across WHO Dimensions of Function After Robot-Based Therapy in Stroke Subjects Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-21 Jennifer Wu; Lucy Dodakian; Jill See; Erin Burke Quinlan; Lisa Meng; Jeby Abraham; Ellen C. Wong; Vu Le; Alison McKenzie; Steven C. Cramer
Background Studies examining the effects of therapeutic interventions after stroke often focus on changes in loss of body function/structure (impairment). However, improvements in activities limitations and participation restriction are often higher patient priorities, and the relationship that these measures have with loss of body function/structure is unclear. Objective This study measured gains
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History of and Insights Into Spinal Cord Stimulation in Parkinson Disease Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-13 Bruno Braz Garcia; Edson Ricardo Junior; Mariana Ferreira Pereira de Araújo; Hougelle Simplício
Background Current available therapies for Parkinson disease (PD) have strong limitations, and patients usually present with refractory symptoms despite all efforts. Deep brain stimulation (DBS), which has been used in PD patients for decades (since 1987), has best indications for symptoms like tremor, motor fluctuations, or dyskinesia. However, postural instability and gait disturbances (PIGD) have
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A Music-Based Digital Therapeutic: Proof-of-Concept Automation of a Progressive and Individualized Rhythm-Based Walking Training Program After Stroke Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-10 Karen Hutchinson; Regina Sloutsky; Ashley Collimore; Benjamin Adams; Brian Harris; Terry D. Ellis; Louis N. Awad
Background The rhythm of music can entrain neurons in motor cortex by way of direct connections between auditory and motor brain regions. Objective We sought to automate an individualized and progressive music-based, walking rehabilitation program using real-time sensor data in combination with decision algorithms. Methods A music-based digital therapeutic was developed to maintain high sound quality
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Mental Imagery as a Rehabilitative Therapy for Neuropathic Pain in People With Spinal Cord Injury: A Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-10 Jaskirat Kaur; Shampa Ghosh; Asish Kumar Sahani; Jitendra Kumar Sinha
Background Pain of neuropathic origin in spinal cord injury (SCI) is unbearable and challenging to treat. Research studies conducted in the past have shown that mental imagery (MI) techniques have a significant impact on the reduction of symptoms of central neuropathic pain in people with SCI. Objectives The objective of this study was to evaluate the effect of MI training on pain intensity, neuropathic
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Translational Approaches to Electrical Stimulation for Peripheral Nerve Regeneration Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-10 Seth C. Ransom; Shane Shahrestani; Brian V. Lien; Ali R. Tafreshi; Nolan J. Brown; Brian Hanst; Brandon M. Lehrich; R. Chase Ransom; Ronald Sahyouni
Background Achieving functional repair after peripheral nerve injury (PNI) remains problematic despite considerable advances in surgical technique. Therein, questions lie regarding the variable capacity of peripheral nerves to regenerate based on environmental influence. In-depth analyses of multiple therapeutic strategies have ensued to overcome these natural obstacles. Of these candidate therapies
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Improvement of the Upper Extremity at the Subacute Stage Poststroke: Does Hand Dominance Play a Role? Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-05 Samar Hmaied Assadi; Revital Feige Gross-Nevo; Israel Dudkiewicz; Haim Barel; Debbie Rand
Background The impact of hand dominance on the expected (motor and functional ability and daily use) improvement of the affected upper extremity (UE) in subacute stroke has not yet been investigated. Objectives To compare between the affected dominant and affected nondominant UE (1) on rehabilitation admission (T1) for motor and sensory abilities, functional ability, and daily use and (2) 6 weeks poststroke
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Conditioned Pain Modulation Decreases Over Time in Patients With Neuropathic Pain Following a Spinal Cord Injury Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-03 Martin Gagné; Isabelle Côté; Mélanie Boulet; Catherine R. Jutzeler; John L. K. Kramer; Catherine Mercier
Background Neuropathic pain is a major problem following spinal cord injury (SCI). Central mechanisms involved in the modulation of nociceptive signals have been shown to be altered at the chronic stage, and it has been hypothesized that they might play a role in the development of chronic pain. Objective This prospective longitudinal study aimed to describe the evolution of pain modulation mechanisms
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Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson’s Disease Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-10-01 Victor Spiandor Beretta; Rodrigo Vitório; Priscila Nóbrega-Sousa; Núbia Ribeiro Conceição; Diego Orcioli-Silva; Marcelo Pinto Pereira; Lilian Teresa Bucken Gobbi
Background Habituation of postural response to perturbations is impaired in people with Parkinson’s disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective To analyze the effect of different intensities of anodal tDCS on postural responses and
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Greater Occipital Nerve Stimulation Boosts Associative Memory in Older Individuals: A Randomized Trial. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-23 Alison M Luckey,S Lauren McLeod,Ian H Robertson,Wing Ting To,Sven Vanneste
Transcutaneous electrical stimulation (tES) is a new approach that aims to stimulate the brain. Recently, we have developed tES approaches to enhance plasticity that modulate cortical activity via the greater occipital nerve (ON) in a “bottom-up” way. Thirty subjects between the ages of 55 and 70 years were enrolled and tested using a double-blind, sham-controlled, and randomized design. Half of the
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The Effect of One Session Split-Belt Treadmill Training on Gait Adaptation in People With Parkinson's Disease and Freezing of Gait. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-17 Jana Seuthe,Nicholas D'Cruz,Pieter Ginis,Jos Steffen Becktepe,Burkhard Weisser,Alice Nieuwboer,Christian Schlenstedt
Background Freezing of gait (FOG) in Parkinson’s disease (PD) is associated with gait asymmetry and switching difficulty. A split-belt treadmill may potentially address those deficits. Objective To investigate the immediate and retention effects of one-session split-belt treadmill training (SBT) in contrast to regular tied-belt treadmill training (TBT) on gait asymmetry and adaptation in people with
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Acute Routine Leukocyte and Neutrophil Counts Are Predictive of Poststroke Recovery at 3 and 12 Months Poststroke: An Exploratory Study. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-17 Vinh A Nguyen,Sheila G Crewther,David W Howells,Tissa Wijeratne,Henry Ma,Graeme J Hankey,Stephen Davis,Geoffrey A Donnan,Leeanne M Carey
Background and Aims. White blood cell (WBC) and neutrophil counts (NC) are common markers of inflammation and neurological stroke damage and could be expected to predict poststroke outcomes. Objective. The aim of this study was to explore the prognostic value of early poststroke WBC and NC to predict cognition, mood, and disability outcomes at 3 and 12 months poststroke. Methods. Routine clinical analyses
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White Matter Hyperintensities Predict Response to Language Treatment in Poststroke Aphasia. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-13 Maria Varkanitsa,Claudia Peñaloza,Andreas Charidimou,David Caplan,Swathi Kiran
Background White matter hyperintensities (WMH) are a radiological marker of brain health that has been associated with language status in poststroke aphasia; however, its association with language treatment outcomes remains unknown. Objective To determine whether WMH in the right hemisphere (RH) predict response to language therapy independently from demographics and stroke lesion–related factors in
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Physiotherapy in Parkinson's Disease: A Meta-Analysis of Present Treatment Modalities. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-11 Danique L M Radder,Ana Lígia Silva de Lima,Josefa Domingos,Samyra H J Keus,Marlies van Nimwegen,Bastiaan R Bloem,Nienke M de Vries
Background Physiotherapy is a commonly prescribed intervention for people with Parkinson’s disease (PD). Conventional types of physiotherapy have been studied extensively, while novel modalities are being developed and evaluated. Objective To evaluate the effectiveness of conventional and more recent physiotherapy interventions for people with PD. The meta-analysis performed as part of the 2014 European
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Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-11 Paul Carrillo-Mora,Verónica Pérez-De la Cruz,Berenice Estrada-Cortés,Paola Toussaint-González,José Antonio Martínez-Cortéz,Marlene Rodríguez-Barragán,Jimena Quinzaños-Fresnedo,Fernanda Rangel-Caballero,Gabriela Gamboa-Coria,Itzel Sánchez-Vázquez,Karina Barajas-Martínez,Kenia Franyutti-Prado,Laura Sánchez-Chapul,Daniela Ramírez-Ortega,Lucio A Ramos-Chávez
Background Poststroke depression (PSD) is related to adverse functional and cognitive prognosis in stroke patients. The participation of kynurenine pathway metabolites in depression has been previously proposed; however, there are few studies on its role in PSD and disability in stroke. Objective To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression
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Comparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-09-10 Serena-Kaye Kinley-Cooper Sims,Aitana Rizzo,Kern Howard,Ariana Farrand,Heather Boger,DeAnna L Adkins
Background Combinatory intervention such as high-frequency (50-100 Hz) excitatory cortical stimulation (ECS) given concurrently with motor rehabilitative training (RT) improves forelimb function, except in severely impaired animals after stroke. Clinical studies suggest that low-frequency (≤1 Hz) inhibitory cortical stimulation (ICS) may provide an alternative approach to enhance recovery. Currently
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Prefrontal Cortex Activity During Walking: Effects of Aging and Associations With Gait and Executive Function. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-31 Priscila Nóbrega-Sousa,Lilian Teresa Bucken Gobbi,Diego Orcioli-Silva,Núbia Ribeiro da Conceição,Victor Spiandor Beretta,Rodrigo Vitório
Background Declines in gait parameters are common with aging and more pronounced in tasks with increased executive demand. However, the neural correlates of age-related gait impairments are not fully understood yet. Objectives To investigate (a) the effects of aging on prefrontal cortex (PFC) activity and gait parameters during usual walking, obstacle crossing and dual-task walking and (b) the association
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Pushing the Rehabilitation Boundaries: Hand Motor Impairment Can Be Reduced in Chronic Stroke. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-26 Firas Mawase,Kendra Cherry-Allen,Jing Xu,Manuel Anaya,Shintaro Uehara,Pablo Celnik
Background. Stroke is one of the most common causes of physical disability worldwide. The majority of survivors experience impairment of movement, often with lasting deficits affecting hand dexterity. To date, conventional rehabilitation primarily focuses on training compensatory maneuvers emphasizing goal completion rather than targeting reduction of motor impairment. Objective. We aim to determine
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Rudimentary Dexterity Corresponds With Reduced Ability to Move in Synergy After Stroke: Evidence of Competition Between Corticoreticulospinal and Corticospinal Tracts? Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-24 Merav R Senesh,Karina Barragan,David J Reinkensmeyer
Objective When a stroke damages the corticospinal tract (CST), it has been hypothesized that the motor system switches to using the corticoreticulospinal tract (CRST) resulting in abnormal arm synergies. Is use of these tracts mutually exclusive, or can the motor system spontaneously switch between them depending on the type of movement it wants to make? If the motor system can share control at will
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Attentional Resource Associated With Visual Feedback on a Postural Dual Task in Parkinson's Disease. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-24 Shu-Han Yu,Ruey-Meei Wu,Cheng-Ya Huang
Background Restricted attentional resource and central processing in patients with Parkinson’s disease (PD) may reduce the benefit of visual feedback in a dual task. Objectives Using brain event-related potentials (ERPs), this study aims to investigate the neural mechanisms of posture visual feedback and supraposture visual feedback during performing of a posture-motor dual task. Methods Eighteen patients
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The Efficiency, Efficacy, and Retention of Task Practice in Chronic Stroke. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-24 Chunji Wang,Carolee Winstein,David Z D'Argenio,Nicolas Schweighofer
In motor skill learning, larger doses of practice lead to greater efficacy of practice, lower efficiency of practice, and better long-term retention. Whether such learning principles apply to motor practice after stroke is unclear. Here, we developed novel mixed-effects models of the change in the perceived quality of arm movements during and following task practice. The models were fitted to data
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Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Contralesional Motor Cortex for Motor Recovery in Subacute Ischemic Stroke: A Randomized Sham-Controlled Trial. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-18 Won-Seok Kim,Bum Sun Kwon,Han Gil Seo,Jihong Park,Nam-Jong Paik
Background Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the contralesional motor cortex (M1) has demonstrated beneficial effects on motor recovery, but evidence among patients with subacute stroke is lacking. We aimed to investigate whether 1-Hz rTMS over the contralesional M1 versus sham rTMS could improve arm function in patients with subacute ischemic stroke when combined
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Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB/NLRP3 Signaling Pathway. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-10 Yunliang Tang,Xiaoyang Dong,Gengfa Chen,Wen Ye,Junwei Kang,Yang Tang,Zhen Feng
Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Oxidative stress, inflammation, and apoptosis are vital pathophysiological features post-TBI. Objectives Research has shown that vagus nerve stimulation (VNS) can attenuate oxidative stress in various diseases. However, the critical role of VNS in TBI is still not completely understood. This study investigated
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Predictors of Access to Rehabilitation in the Year Following Traumatic Brain Injury: A European Prospective and Multicenter Study. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-08-07 Louis Jacob,Mélanie Cogné,Olli Tenovuo,Cecilie Røe,Nada Andelic,Marek Majdan,Jukka Ranta,Peter Ylen,Helen Dawes,Philippe Azouvi,
Background Although rehabilitation is beneficial for individuals with traumatic brain injury (TBI), a significant proportion of them do not receive adequate rehabilitation after acute care. Objective Therefore, the goal of this prospective and multicenter study was to investigate predictors of access to rehabilitation in the year following injury in patients with TBI. Methods Data from a large European
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Repeated Concussions Impair Behavioral and Neurophysiological Changes in the Motor Learning System. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-29 Gabriela Cantarero,Jake Choynowski,Maria St Pierre,Manuel Anaya,Matthew Statton,William Stokes,Vincent Capaldi,Vikram Chib,Pablo Celnik
Background. Concussions affect nearly 3 million people a year and are the leading cause of traumatic brain injury–related emergency department visits among youth. Evidence shows neuromotor regions are sensitive to concussive events and that motor symptoms may be the earliest clinical manifestations of neurodegenerative traumatic brain injuries. However, little is known about the effects repeated concussions
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The Damaged Spinal Cord Is a Suitable Target for Stem Cell Transplantation. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-23 Armin Curt,Jane Hsieh,Martin Schubert,Markus Hupp,Susanne Friedl,Patrick Freund,Evenline Huber,Dario Pfyffer,Reto Sutter,Catherine Jutzeler,Rudolf P Wüthrich,Kan Min,Steve Casha,Michael G Fehlings,Raphael Guzman
Background. Given individuals with spinal cord injury (SCI) approaching 2 million, viable options for regenerative repair are desperately needed. Human central nervous system stem cells (HuCNS-SC) are self-renewing, multipotent adult stem cells that engraft, migrate, and differentiate in appropriate regions in multiple animal models of injured brain and spinal cord. Preclinical improved SCI locomotor
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Electroencephalographic Phase Synchrony Index as a Biomarker of Poststroke Motor Impairment and Recovery. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-21 Teiji Kawano,Noriaki Hattori,Yutaka Uno,Megumi Hatakenaka,Hajime Yagura,Hiroaki Fujimoto,Tomomi Yoshioka,Michiko Nagasako,Hironori Otomune,Keiichi Kitajo,Ichiro Miyai
Background. Motor recovery after stroke is of great clinical interest. Besides magnetic resonance imaging functional connectivity, electroencephalographic synchrony is also an available biomarker. However, the clinical relevance of electroencephalographic synchrony in hemiparesis has not been fully understood. Objective. We aimed to demonstrate the usefulness of the phase synchrony index (PSI) by showing
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Distinct Effects of Motor Training on Resting-State Functional Networks of the Brain in Parkinson's Disease. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-18 Amgad Droby,Inbal Maidan,Yael Jacob,Nir Giladi,Jeffrey M Hausdorff,Anat Mirelman
Background. Nigrostriatal dopaminergic loss is a hallmark of Parkinson’s disease (PD) pathophysiology, leading to motor Parkinsonism. Different intervention protocols have shown that motor and cognitive functions improvement in PD occur via the modulation of distinct motor and cognitive pathways. Objective. To investigate the effects of two motor training programs on the brains’ functional networks
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Assessment of Sex Differences in Recovery of Motor and Sensory Impairments Poststroke. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-16 Rachel L Hawe,Tyler Cluff,Dar Dowlatshahi,Michael D Hill,Sean P Dukelow
Background. Understanding potential sex differences in stroke recovery is important for prognosis, ensuring appropriate allocation of health care resources, and for stratification in research studies. Previously, functional measures have shown poorer outcomes for females, however, little is known about sex differences that may exist in specific motor and sensory impairments. Objective. The aim of this
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Quantifying Postural Control in Premanifest and Manifest Huntington Disease Using Wearable Sensors. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-16 Franchino Porciuncula,Paula Wasserman,Karen S Marder,Ashwini K Rao
Background. Impairments in postural control in Huntington disease (HD) have important consequences for daily functioning. This observational study systematically examined baseline postural control and the effect of sensory attenuation and sensory enhancement on postural control across the spectrum of HD. Methods. Participants (n = 39) included healthy controls and individuals in premanifest (pHD) and
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Change in Right Inferior Longitudinal Fasciculus Integrity Is Associated With Naming Recovery in Subacute Poststroke Aphasia. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-16 Marieke Blom-Smink,Marjolein Verly,Kerstin Spielmann,Marion Smits,Gerard M Ribbers,Mieke W M E van de Sandt-Koenderman
Background. Despite progress made in understanding functional reorganization patterns underlying recovery in subacute aphasia, the relation between recovery and changes in white matter structure remains unclear. Objective. To investigate changes in dorsal and ventral language white matter tract integrity in relation to naming recovery in subacute poststroke aphasia. Methods. Ten participants with aphasia
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Acute Traumatic and Ischemic Spinal Cord Injuries Have a Comparable Course of Recovery. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-13 Giorgio Scivoletto,Monica Torre,Alessia Mammone,Doris D Maier,Norbert Weidner,Martin Schubert,Ruediger Rupp,Rainer Abel,Kalke Yorck-Bernhard,Kriz Jiri,Armin Curt,Marco Molinari
Background. The relative rarity of ischemic compared with traumatic spinal cord injury (SCI) has limited a comparison of the outcomes of these conditions. Objective. To investigate the neurological and functional recovery of ischemic compared with traumatic acute SCI. Methods. Data were derived from the European Multicenter Study Spinal Cord Injury database. Patients with ischemic (iSCI) or traumatic
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Backward Protective Stepping During Dual-Task Scenarios in People With Parkinson's Disease: A Pilot Study. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-07-07 Daniel S Peterson,Jordan S Barajas,Linda Denney,Shyamal H Mehta
Introduction. Reactive movements in response to a loss of balance are altered in people with Parkinson’s disease (PD) and are critical for fall prevention. Further, falls are more common while attention is divided. Although divided attention has been shown to impact postural responses in healthy older adults, the impact of dividing attention on reactive balance, and the natural prioritization across
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tDCS Accelerates the Rehabilitation of MCAO-Induced Motor Function Deficits via Neurogenesis Modulated by the Notch1 Signaling Pathway. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-06-16 Keying Zhang,Ling Guo,Junping Zhang,Gang Rui,Guangzhou An,Yan Zhou,Jiajin Lin,Junling Xing,Tao Zhao,Guirong Ding
Background. Ischemic stroke carries a high mortality rate and is a leading cause of severe neurological disability. However, the efficacy of current therapeutic options remains limited. Objective. We aimed to investigate the treatment efficacy of transcranial direct current stimulation (tDCS) in motor function rehabilitation after ischemic stroke and explore the underlying mechanisms. Methods. Male
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Sleep Disruption After Brain Injury Is Associated With Worse Motor Outcomes and Slower Functional Recovery. Neurorehabilit. Neural Repair (IF 3.982) Pub Date : 2020-06-07