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Minimal effects from a single exposure to sevoflurane in adult male and female Sprague-Dawley rats Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2021-01-16 Timothy J. Flanigan; Charles D. Law; Sherry A. Ferguson
Many people undergo procedures requiring general anesthesia each day and adverse cognitive effects have been reported in response to that anesthesia. Postoperative Cognitive Dysfunction (POCD) may occur in as many as 80% of adults during the first post-surgical week and can have lasting effects. Here, the cognitive and motor effects of sevoflurane exposure in Sprague-Dawley rats was examined along
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Lead exposure affects cephalic morphogenesis and neural crest cells in Gallus gallus embryo Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2021-01-05 Mariliza Cristine Vieira da Costa; Melyssa Kmecick; Patricia Franchi de Freitas; Claudia Feijó Ortolani-Machado
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Prenatal phthalate exposures and autism spectrum disorder symptoms in low-risk children Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2021-01-05 Diana K. Haggerty; Rita S. Strakovsky; Nicole M. Talge; Courtney C. Carignan; Alicynne N. Glazier-Essalmi; Brooke R. Ingersoll; Rajendiran Karthikraj; Kurunthachalam Kannan; Nigel S. Paneth; Douglas M. Ruden
Background Prenatal exposure to environmental chemicals has been associated with Autism Spectrum Disorder (ASD) symptoms in some, but not all, studies, but most research has not accounted for other childhood behavior problems. Objectives To evaluate the specific associations of prenatal phthalate exposures with ASD symptoms in children (ages 3–6) accounting for other behavior problems, and to assess
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Organophosphorus-based chemical additives induced behavioral changes in zebrafish (Danio rerio): Swimming activity is a sensitive stress indicator Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-12-14 Rama-Krishnan Poopal; Yaqi He; Ruibin Zhao; Bin Li; Mathan Ramesh; Zongming Ren
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Fatty acid ethyl esters in meconium and substance use in adolescence Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-12-23 Meeyoung O. Min; Sonia Minnes; Hasina Momotaz; Lynn T. Singer; Anna Wasden; Cynthia F. Bearer
Prenatal alcohol exposure (PAE) continues to be a serious public health problem, yet no reliable clinical tools are available for assessing levels of drinking during pregnancy. Fatty acid ethyl esters (FAEEs), the nonoxidative metabolites of ethanol measured in meconium, are potential biomarkers to quantify the level of PAE. The association between the concentrations of FAEEs from meconium and adolescent
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Hippocampal subfield abnormalities and memory functioning in children with fetal alcohol Spectrum disorders Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-11-21 Donovan J. Roediger; Alyssa M. Krueger; Erik de Water; Bryon A. Mueller; Christopher A. Boys; Timothy J. Hendrickson; Mariah J. Schumacher; Sarah N. Mattson; Kenneth L. Jones; Kelvin O. Lim; Jeffrey R. Wozniak
Background Prenatal alcohol exposure (PAE) affects early brain development and has been associated with hippocampal damage. Animal models of PAE have suggested that some subfields of the hippocampus may be more susceptible to damage than others. Recent advances in structural MRI processing now allow us to examine the morphology of hippocampal subfields in humans with PAE. Method Structural MRI scans
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A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-11-20 Nihal A. Salem; Amanda H. Mahnke; Alexander M. Tseng; Cadianna R. Garcia; Hooman K. Jahromi; Cédric G. Geoffroy; Rajesh C. Miranda
Prenatal ethanol exposure can result in loss of neural stem cells (NSCs) and decreased brain growth. Here, we assessed whether a noncoding RNA (ncRNA) related to the NSC self-renewal factor Oct4/Pou5f1, and transcribed from a processed pseudogene locus on mouse chromosome 9 (mOct4pg9), contributed to the loss of NSCs due to ethanol. Mouse fetal cortical-derived NSCs, cultured ex vivo to mimic the early
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Characterizing the effects of in utero valproic acid exposure on NF-κB signaling in CD-1 mouse embryos during neural tube closure Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-11-16 Sidra Shafique; Louise M. Winn
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Environmental level of the antidepressant venlafaxine induces behavioral disorders through cortisol in zebrafish larvae (Danio rerio) Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-11-18 Yaqiu Tang; Ping Mi; Meijuan Li; Shaozhi Zhang; Jie Li; Xizeng Feng
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Combined vapor exposure to THC and alcohol in pregnant rats: Maternal outcomes and pharmacokinetic effects Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-10-18 Kristen R. Breit; Cristina G. Rodriguez; Annie Lei; Jennifer D. Thomas
Cannabis is the most frequently used illicit drug among pregnant women, yet the potential consequences of prenatal cannabis exposure on development are not well understood. Electronic cigarettes have become an increasingly popular route of administration among pregnant women, in part to user's perception that e-cigarettes are a safer route for consuming cannabis products. Importantly, half of pregnant
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A single dose of the organophosphate triazophos induces fear extinction deficits accompanied by hippocampal acetylcholinesterase inhibition Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-10-06 João Vitor Ferreira Rodrigues; Anna Paula Perin Vidigal; Vítor Sampaio Minassa; Thatiany Jardim Batista; Randriely Merscher Sobreira de Lima; Vinícius Rafael Funck; Leandro S. Antero; Leonardo Barbosa Moraes Resstel; Juliana Barbosa Coitinho; Leandro Jose Bertoglio; Karla Nívea Sampaio; Vanessa Beijamini
Acute organophosphate (OP) poisoning, particularly by suicide attempts, generates high mortality and morbidity. Few studies have systematically addressed the consequences of acute OP intoxication on cognition and memory of survivors. Preclinical evidence suggests that acute OP-induced effects are associated with inhibiting the brain acetylcholinesterase (AChE) enzyme. The OP triazophos has been used
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A possible neuroprotective property of ethanol and/or NeuroAiD on the modulation of cognitive function. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-08-27 Mohammad Nasehi,Setareh Nouri Zadeh-Tehrani,Fatemeh Khakpai,Mohammad-Reza Zarrindast
Cognitive impairments and poor performance on tasks needing behavioral flexibility are observable in chronic alcohol exposure. NeuroAid decreases cognitive deficits and improves functional outcomes by restoring neuronal circuits. The aim of the current study was to assess the hypothesis that ethanol exposure would induce neurobehavioral defects which may be reversed by the neuroprotective property
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Protective effects of quercetin, polydatin, and folic acid and their mixtures in a zebrafish (Danio rerio) fetal alcohol spectrum disorder model. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-08-27 Pabyton Gonçalves Cadena,Marilia Ribeiro Sales Cadena,Swapnalee Sarmah,James A Marrs
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Organophosphorus flame retardant induced hepatotoxicity and brain AChE inhibition on zebrafish (Danio rerio). Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-08-24 Mathan Ramesh,Sajeev Angitha,Satheesh Haritha,Rama-Krishnan Poopal,Zongming Ren,Sathisaran Umamaheswari
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Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-07-27 Afolarin O Ogungbemi,Elisabet Teixido,Riccardo Massei,Stefan Scholz,Eberhard Küster
Neuroactive chemicals are frequently detected in the environment. At sufficiently high concentrations or within mixtures, they could provoke neurotoxic effects and neurological diseases to organisms and humans. Fast identification of such neuroactive compounds in the environment could help in hazard assessment and risk mitigation. Behavior change is considered as an important endpoint and might be
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This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-07-19 Leslie Y Kwan,David L Eaton,Susan L Andersen,Diana Dow-Edwards,Edward D Levin,John Talpos,Charles V Vorhees,Abby A Li
Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, that brought together experts in research on drug dependence and toxicity related to
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Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-07-18 Suena H Massey,Caron A C Clark,Michael Y Sun,James L Burns,Daniel K Mroczek,Kimberly A Espy,Lauren S Wakschlag
Objective Precise phenotypic characterization of prenatal tobacco exposure (PTE)–related disruptive behavior (DB) that integrates nuanced measures of both exposures and outcomes is optimal for elucidating underlying mechanisms. Using this approach, our goals were to identify dimensions of DB most sensitive to PTE prior to school entry and assess contextual variation in these dimensions. Methods A community
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Sub-lethal toxicity assessment of the phenylurea herbicide linuron in developing zebrafish (Danio rerio) embryo/larvae. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-07-23 Sapna Maharaj,Nader El Ahmadie,Spencer Rheingold,Jana El Chehouri,Lihua Yang,Christopher L Souders,Christopher J Martyniuk
Due to run-off and rain events, agrochemicals can enter water catchments, exerting endocrine disruption effects and toxicity to aquatic organisms. Linuron is a phenylurea herbicide used to control a wide variety of vegetative weeds in agriculture in addition to residential applications. However, there are few studies that quantify its toxicity to early developmental stages of fish. The objectives of
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Learning and memory retention deficits in prepubertal guinea pigs prenatally exposed to low levels of the organophosphorus insecticide malathion. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-07-09 Eric W Lumsden,Lillian McCowan,Joseph D Pescrille,William P Fawcett,Hegang Chen,Edson X Albuquerque,Jacek Mamczarz,Edna F R Pereira
High doses of malathion, an organophosphorus (OP) insecticide ubiquitously used in agriculture, residential settings, and public health programs worldwide, induce a well-defined toxidrome that results from the inhibition of acetylcholinesterase (AChE). However, prenatal exposures to malathion levels that are below the threshold for AChE inhibition have been associated with increased risks of neurodevelopmental
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Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-06-17 R M Foguth,T D Hoskins,G C Clark,M Nelson,R W Flynn,C de Perre,J T Hoverman,L S Lee,M S Sepúlveda,J R Cannon
Per- and polyfluoroalkyl substances (PFAS) are present in water and >99% of human serum. They are found in brains of wildlife; however, little is known about effects on the developing brain. To determine the effects of PFAS on brain and cardiac innervation, we conducted an outdoor mesocosm experiment with Northern leopard frog larvae (Rana pipiens) exposed to control, 10 ppb perfluorooctane sulfonate
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Characterization of performance on an automated visual recognition memory task in 7.5-month-old infants. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-30 Kelsey L C Dzwilewski,Francheska M Merced-Nieves,Andrea Aguiar,Susan A Korrick,Susan L Schantz
Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to automate collection and processing of looking behavior data, making it possible to efficiently
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Sex dependent alterations of resveratrol on social behaviors and nociceptive reactivity in VPA-induced autistic-like model in rats. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-06-11 Kobra Bahrampour Juybari,Gholamreza Sepehri,Manzumeh Shamsi Meymandi,Seyyed Sajjad Vakili Shahrbabaki,Amirhossein Moslemizadeh,Nima Saeedi,Azadeh Aminzadeh,Masoumeh Nozari,Mohammad Khaksari,Tahereh Haghpanah,Hamideh Bashiri
Introduction The present study was designed to clarify the effects of resveratrol (RSV) on social behavioral alterations and nociceptive reactivity in valproic acid (VPA)-induced autistic-like model in female and male rats. Methods Pregnant Wistar rats were randomly divided in five groups. Animals received saline, DMSO, VPA, RSV and RSV + VPA. VPA was administered (600 mg/kg, i. p.) on embryonic day
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Does prenatal cocaine exposure predict adolescent substance use? Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-06-11 David S Bennett,Michael Lewis
Prenatal cocaine exposure (PCE) has rarely been examined as a predictor of substance use during late adolescence, and few studies have examined both the initiation of substance use and current substance use as outcomes. The present longitudinal study examined PCE, other prenatal exposures, and psychosocial risk factors for their association with substance use in mid to late adolescence. Adolescents
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Risk factors associated with developing anxiety in Inuit adolescents from Nunavik. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-06-06 Vickie Lamoureux-Tremblay,Gina Muckle,Françoise Maheu,Sandra W Jacobson,Joseph L Jacobson,Pierre Ayotte,Richard E Bélanger,Dave Saint-Amour
This study aimed to examine the relation between anxiety among the at-risk population of Inuit adolescents and diverse developmental risk factors including exposure to environmental chemicals, a subject of concern in Nunavik. Anxiety was assessed in 89 Inuit participants (mean age = 18.4 years; range = 16.2–21.9) with the Screen for Child Anxiety Related Emotional Disorders (SCARED) and the State-Trait
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Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-27 Anthony N Oliveri,Lilah Glazer,Debabrata Mahapatra,Seth W Kullman,Edward D Levin
Vitamin D receptor (VDR) signaling is important for optimal neurobehavioral development. Disruption of VDR signaling by environmental toxicants during early development might contribute to the etiology of behavioral dysfunction. In the current set of studies, we examined ten compounds known to affect VDR function in vitro for neurobehavioral effects in vivo in zebrafish. Zebrafish embryos were exposed
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High prevalence of prenatal alcohol exposure detected by breathalyzer in the Republic of the Congo, Africa. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-15 Jacob R Greenmyer,Marilyn G Klug,Gery Nkodia,Svetlana Popova,Brandon Hart,Larry Burd
OBJECTIVE Assess the prevalence of prenatal alcohol exposure in the Republic of the Congo by measuring breath alcohol concentration (BrAC) levels using a breathalyzer device. METHODS Pregnant women were assessed for alcohol use with a breathalyzer reading during two prenatal visits and during labor and delivery. RESULTS Among 662 pregnant women consented and screened with a breathalyzer, 192 (29.0%)
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Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-12 Susan M Burks,John F Bowyer,Jennifer L Walters,John C Talpos
Extended general anesthesia early in life is neurotoxic in multiple species. However, little is known about the temporal progression of neurodegeneration after general anesthesia. It is also unknown if a reduction in natural cell death, or an increase in cell creation, occurs as a form of compensation after perinatal anesthesia exposure. The goal of this study was to evaluate markers of neurodegeneration
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Maternal smoking in pregnancy, fetal activity & newborn behavioral state: An observational ultrasound study. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-11 Laura R Stroud,Margaret H Bublitz,Frank A Crespo,Barry Lester,Amy L Salisbury
Maternal smoking during pregnancy (MSDP) remains one of the most common prenatal drug exposures in the US and worldwide. MSDP is associated with medical risk for the fetus and altered behavioral development in infants; however, fewer studies have examined the impact of MSDP on fetal behavior or newborn behavioral state. We investigated associations between MSDP and (a) fetal motor activity and (b)
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Sex differences in the interactive effects of early life stress and the endocannabinoid system. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-11 Diana Dow-Edwards
Sex differences in both the endocannabinoid system and stress responses have been established for decades. While there is ample evidence that the sexes respond differently to stress and that the endocannabinoid system is involved in this response, what is less clear is whether the endocannabinoid system mediates this response to stress differently in both sexes. Also, do the sexes respond similarly
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Blood lead levels ≤10 micrograms/deciliter and executive functioning across childhood development: A systematic review. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-05 Olivia M Arnold,Jianghong Liu
At low levels, the effects of lead on specific neurocognitive processes, such as executive functioning, is not well understood. The aim of this systematic review is to synthesize the empirical literature examining the relationship between prenatal and postnatal low blood lead levels and executive function across childhood development. This review considers the unity and diversity model of executive
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Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-05-03 Jennifer L Walters,John J Chelonis,Charles M Fogle,Sherry A Ferguson,Sumit Sarkar,Merle G Paule,John C Talpos
Many studies have shown that prolonged or repeated use of general anesthesia early in life can cause an increase in neurodegeneration and lasting changes in behavior. While short periods of general anesthesia appear to be safe, there is a concern about the neurotoxic potential of prolonged or repeated general anesthesia in young children. Unfortunately, the use of general anesthesia in children cannot
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Autonomic functioning among cocaine-exposed kindergarten-aged children: Examination of child sex and caregiving environmental risk as potential moderators. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-28 Pamela Schuetze,Rina D Eiden,Shannon Shisler
The purpose of this study was to examine the hypothesis that child sex moderates the association between prenatal cocaine exposure (PCE) and autonomic functioning as well as to examine the role that caregiving environmental risk played in sex differences in autonomic functioning among exposed children. Measures of the parasympathetic nervous system (indexed by respiratory sinus arrhythmia [RSA]) and
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Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-26 Aimée I Vester,Karen Hermetz,Amber Burt,Todd Everson,Carmen J Marsit,William M Caudle
Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders and manifests inattention, hyperactivity, and impulsivity symptoms in childhood that can last throughout life. Genetic and environmental studies implicate the dopamine system in ADHD pathogenesis. Work from our group and that of others indicates that deltamethrin insecticide and stress exposure during
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Behavioral effects in adult rats exposed to low doses of a phthalate mixture during the perinatal or adolescent period. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-18 Elli P Sellinger,Daniel G Kougias,Carly M Drzewiecki,Janice M Juraska
Hormones influence neurodevelopment which can result in vulnerability to endocrine disruptors such as phthalates during both the perinatal period and adolescence. Using a rat model, we have previously shown that perinatal exposure to an environmentally relevant phthalate mixture at low doses results in cognitive flexibility deficits in adults and a reduction in neuron and synapse number within the
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Held in conjunction with the 60th Annual Meeting of the Society for Birth Defects Research and Prevention and the 33rd Annual Education Meeting for the Organization of Teratology Information Specialists, Charleston, South Carolina, June 27-July 1, 2020: Meeting Cancelled due to COVID-19 Global Pandemic. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-13
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Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-11 Kimberly R Wiersielis,Benjamin A Samuels,Troy A Roepke
Endocrine-disrupting compounds (EDCs) are common contaminants in our environment that interfere with typical endocrine function. EDCs can act on steroid and nuclear receptors or alter hormone production. One particular EDC of critical concern is bisphenol A (BPA) due to its potential harm during the perinatal period of development. Previous studies suggest that perinatal exposure to BPA alters several
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Prenatal tobacco and marijuana co-use: Sex-specific influences on infant cortisol stress response. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-11 Laura R Stroud,George D Papandonatos,Nancy C Jao,Chrystal Vergara-Lopez,Marilyn A Huestis,Amy L Salisbury
Although tobacco (TOB) and marijuana (MJ) are often co-used in pregnancy, little is known regarding the joint impact of MJ + TOB on offspring development, including the developing neuroendocrine stress system. Further, despite evidence for sex-specific impacts of prenatal exposures in preclinical models, the sex-specific impact of prenatal MJ + TOB exposure on offspring neuroendocrine regulation in
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Sex-specific effects of developmental exposure to polychlorinated biphenyls on neuroimmune and dopaminergic endpoints in adolescent rats. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-04 Deborah A Liberman,Katherine A Walker,Andrea C Gore,Margaret R Bell
Exposure to environmental contaminants early in life can have long lasting consequences for physiological function. Polychlorinated biphenyls (PCBs) are a group of ubiquitous contaminants that perturb endocrine signaling and have been associated with altered immune function in children. In this study, we examined the effects of developmental exposure to PCBs on neuroimmune responses to an inflammatory
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Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-03-30 Dongmei Wang,LongEn Yang,Jingtao Wang,Guojun Hu,ZiYuan Liu,Dongni Yan,Nazar Serikuly,Erik T Alpyshov,Konstantin A Demin,David S Galstyan,Tatiana Strekalova,Murilo S de Abreu,Tamara G Amstislavskaya,Allan V Kalueff
Kava kava (Piper methysticum) is a medicinal plant containing kavalactones that exert potent sedative, analgesic and anti-stress action. However, their pharmacological effects and molecular targets remain poorly understood. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism for neuroscience research and drug discovery. Here, we evaluate the effects of acute and chronic
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Supplemental taurine during adolescence and early adulthood has sex-specific effects on cognition, behavior and neurotransmitter levels in C57BL/6J mice dependent on exposure window. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-04-11 Josephine Brown,Yislain Villalona,Jamie Weimer,Clare Pickering Ludwig,Breann T Hays,Lisa Massie,Cecile A Marczinski,Christine Perdan Curran
The mammalian brain goes through final maturation during late adolescence and early adulthood with sex differences in timing. The key cellular processes, including changes in neurotransmitter receptor density and synaptic pruning, make this age uniquely vulnerable to neurotoxic insults. Teenagers and young adults are the major consumers of energy drinks, which contain high levels of taurine and caffeine
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Inhibition of the electron transport chain in propofol induced neurotoxicity in zebrafish embryos. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-01-07 Lin He,Xuan Wang,Shan Zheng
Fetal and neonatal exposure to propofol can lead to neuronal death and long-term neurobehavioral deficiencies in both rodents and nonhuman primates. Zebrafish embryo, which is fertilized ex-utero, has provided us a new model species to study the effects of general anesthetics on developing brain. Inhibited electron transport chain leads to mitochondrial dysfunction and insufficient energy production
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Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-01-03 Andrew B Hawkey,Lilah Glazer,Cassandra Dean,Corinne N Wells,Kathryn-Ann Odamah,Theodore A Slotkin,Frederic J Seidler,Edward D Levin
Farmers are often chronically exposed to insecticides, which may present health risks including increased risk of neurobehavioral impairment during adulthood and across aging. Experimental animal studies complement epidemiological studies to help determine the cause-and-effect relationship between chronic adult insecticide exposure and behavioral dysfunction. With the zebrafish model, we examined short
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Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-02-14 Laura M Carlson,Frances A Champagne,Deborah A Cory-Slechta,Laura Dishaw,Elaine Faustman,William Mundy,Deborah Segal,Christina Sobin,Carol Starkey,Michele Taylor,Susan L Makris,Andrew Kraft
A key challenge in systematically incorporating mechanistic data into human health assessments is that, compared to studies of apical health endpoints, these data are both more abundant (mechanistic studies routinely outnumber other studies by several orders of magnitude) and more heterogeneous (e.g. different species, test system, tissue, cell type, exposure paradigm, or specific assays performed)
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Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor α-dependent manner in perinatal brain. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-01-09 Allyssa Fahrenkopf,Christine K Wagner
Bisphenol A (BPA) is a xenoestrogen that is prevalent in the environment of industrialized nations due its use in the production of many plastic household items. Virtually all adults in the U.S. have detectable levels of BPA in urine and it can be measured in fetal serum and in breastmilk, making developmental exposure a particular concern. The present study utilizes a progesterone receptor (PR) expression
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Sex differences in the association between exposure to indoor particulate matter and cognitive control among children (age 6-14 years) living near coal-fired power plants. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-01-07 Clara G Sears,Lonnie Sears,Kristina M Zierold
Coal fly ash consists of inhalable particulate matter with varying concentrations of neurotoxic metals. Children living near coal-fired power plants with coal fly ash storage facilities may be exposed to coal fly ash when it escapes as fugitive dust emissions into surrounding communities. Previous research on outdoor particulate matter air pollution of similar aerodynamic diameter (PM10) suggests exposure
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Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-02-27 Thomas W Jackson,Gabriel A Bendfeldt,Kelby A Beam,Kylie D Rock,Scott M Belcher
Sonic hedgehog (SHH) signaling is essential for the differentiation and migration of early stem cell populations during cerebellar development. Dysregulation of SHH-signaling can result in cerebellar overgrowth and the formation of the brain tumor medulloblastoma. Treatment for medulloblastoma is extremely aggressive and patients suffer life-long side effects including behavioral deficits. Considering
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WITHDRAWN: Poster presentations. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2020-03-10 Gideon Koren
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
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Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-11-12 Sagi Enicole A Gillera,William P Marinello,Brian M Horman,Allison L Phillips,Matthew T Ruis,Heather M Stapleton,David M Reif,Heather B Patisaul
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Neuron-specific toxicity of chronic acrylamide exposure in C. elegans. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-11-20 Sydney M Murray,Brandon M Waddell,Cheng-Wei Wu
Acrylamide is a food-borne chemical with well-known neurotoxic properties. To date, the toxicity mechanisms of chronic acrylamide exposure are not fully understood. Using the genetic model Caenorhabditis elegans, we found that chronic acrylamide exposure induces a locomotor defect that is characterized by severe uncoordination of muscle movement that is distinct from an overall reduction in activity
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Paternal valproic acid exposure in mice triggers behavioral alterations in offspring. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-10-22 Daisuke Ibi,Yu Fujiki,Nayu Koide,Genki Nakasai,Rika Takaba,Masayuki Hiramatsu
Sodium valproate (VPA) is the most widely used antiepileptic drug and is increasingly also being used for several non-epileptic indications including migraines and bipolar disorder. It is known that maternal VPA exposure during pregnancy increases the risk of autism spectrum disorder (ASD) in children. Animal model studies have shown that maternal treatment with VPA in rodents conveys an increased
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Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-10-20 Rodrigo Moreno Klein,Camila Rigobello,Camila Borecki Vidigal,Kawane Fabrício Moura,Décio Sabbatini Barbosa,Daniela Cristina Ceccatto Gerardin,Graziela Scalianti Ceravolo,Estefânia Gastaldello Moreira
Paracetamol (PAR) is an over-the-counter medicine used as analgesic or antipyretic by 40-50% of the pregnant women in different countries. Epidemiologic studies have been associating maternal use of PAR with neurodevelopmental disruption and special attention has been given to its potential to increase the odds for neurodevelopmental disorders, such as attention-deficit hyperactive disorder and autism
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Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-10-20 Eren Ogut,Rahime Sekerci,Guven Akcay,Fatos Belgin Yildirim,Narin Derin,Mutay Aslan,Leyla Sati
Recent developments in the field of insecticide exposure have led to a renewed interest in alternative antioxidant therapy. The present study was to investigate the neuroprotective role of syringic acid (SA, 25 mg/kg/day) on the neurotoxicity and oxidative damage induced by deltamethrin (DTM, 1.28 mg/kg/day during two months) in CA1/3 pyramidal neurons. Animals were divided into 4 groups (n = 16/group)
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A combination insecticide at sub-lethal dose debilitated the expression pattern of crucial signalling molecules that facilitate craniofacial patterning in domestic chick Gallus domesticus. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-10-05 Shashikant Sharma,Gowri K Uggini,Isha Desai,Suresh Balakrishnan
Pesticides despite being agents that protect the plants and humans from noxious pests, are infamous for their potential to cause detrimental health issues in nontargeted species. In order to ascertain the latter, a set of experiments were conducted by exposing early chick embryos to a widely used combination insecticide (Ci, 50% chlorpyrifos and 5% cypermethrin). The results revealed a myriad of congenital
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Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-09-10 Ya-Qiu Tang,Zhuo-Ran Li,Shao-Zhi Zhang,Ping Mi,Dong-Yan Chen,Xi-Zeng Feng
Venlafaxine (VEN) is one of the first clinical drugs for the treatment of depression. Long-term use may cause a potentially life-threatening serotonin syndrome. Melatonin (MT) could ameliorate depression behavior. Therefore, the aim of this study was to investigate the antidepressant effects of venlafaxine in combination with melatonin on zebrafish. Reserpine was used to induce depression-like behavioral
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Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-09-07 Diana Dow-Edwards,Frank P MacMaster,Bradley S Peterson,Raymond Niesink,Susan Andersen,B R Braams
Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a process of plasticity which is the structural and functional adaptation of the nervous
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Weekly ethanol exposure alters dopaminergic parameters in zebrafish brain. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-08-14 Maria Cecilia Manenti Alexandre,Niuany Viel Mendes,Carolina Antunes Torres,Samira Leila Baldin,Henrique Teza Bernardo,Rahisa Scussel,Suelen Baggio,Ben Hur Marins Mussulini,Kamila Cagliari Zenki,Maria Inês da Rosa,Eduardo Pacheco Rico
Binge drinking is defined as the infrequent consumption of excessive doses of alcohol in a short period of time. Zebrafish is a reliable model to investigate ethanol consumption impact on the CNS, including reward signaling like dopaminergic neurotransmission system. The aim of this study was to evaluate zebrafish brain dopaminergic parameters after intermittent weekly ethanol exposure (WEE), which
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ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-08-08 Pingping Sun,Lingqi Gu,Jiashan Luo,Yi Qin,Lingli Sun,Shengyang Jiang
Recent studies have indicated that perfluorooctane sulfonate (PFOS) and its derivatives can lead to neurotoxicity. In the present study, we showed that PFOS may trigger neuronal apoptosis through a c-Jun N-terminal kinase (JNK)-related mechanism. We revealed that c-Jun N-terminal kinase (JNK) was robustly activated in PFOS-exposed neuronal cells. The doses of PFOS that initiates JNK activation coincides
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Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-06-26 Jing Xu,Michael Xu,YuChia Wang,R Paige Mathena,Jieqiong Wen,Pengbo Zhang,Orion Furmanski,C David Mintz
BACKGROUND General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the mechanism by which isoflurane prevents sensing of the repulsive guidance cue, Semaphorin
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Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-06-26 Guohui Li,Jian'er Du,Lai Wang,Xueyin Shi
Animal studies have demonstrated that multiple exposures to sevoflurane during the postnatal period lead to impaired synaptogenesis and cognitive deficits in adulthood. However, the underlying mechanisms remain unclear. Histone deacetylase 6 (HDAC6), a unique isoform of class II histone deacetylases (HDACs), mediates diverse cellular processes such as cell survival, inflammation, intracellular trafficking
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Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae. Neurotoxicol. Teratol. (IF 3.274) Pub Date : 2019-05-31 Manigandan Krishnan,Sun Chul Kang
Neuroinflammation is crucial for the pathophy