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Tau imaging in late traumatic brain injury: a [18F]MK-6240 PET study. J. Neurotrauma (IF 4.2) Pub Date : 2023-12-01 Greet Vanderlinden,Laura Michiels,Michel Koole,Robin Lemmens,Dirk Liessens,Jan Van Walleghem,Bart Depreitere,Mathieu Vandenbulcke,Koen Van Laere
Epidemiological studies have identified prior traumatic brain injury (TBI) as a risk factor for developing Alzheimer's disease (AD). Neurofibrillary tangles (NFTs) are common to AD and chronic traumatic encephalopathy following repetitive mild TBI. However, it is unclear if a single TBI is sufficient to cause accumulation of NFTs. We performed a [18F]MK-6240 positron emission tomography (PET) imaging
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Convergent and Discriminant Validity of the Blast Exposure Threshold Survey in U.S Military Service Members and Veterans. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-30 Rael T Lange,Louis M French,Sara M Lippa,Kelly Gillow,Jason Bailie,Stephanie Turner,Lars Hungerford,Tracey A Brickell
The Blast Exposure Threshold Survey (BETS) is a recently developed and promising new self-report measure of lifetime blast exposure (LBE). However, there are no studies that have examined the psychometric properties of the BETS which currently limits its clinical utility. The purpose of this study was to examine the convergent and discriminant validity of the BETS by comparing the BETS Generalized
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Enhancing Triage and Patient Care: Lessons from a Mobile CT Unit in Managing Mild Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-30 Daniel P O Kaiser
N/A.
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Machine Learning Web Application for Predicting Functional Outcomes in Patients With Traumatic Spinal Cord Injury Following Inpatient Rehabilitation. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-28 Satoshi Maki,Takeo Furuya,Takaki Inoue,Atsushi Yunde,Masataka Miura,Yuki Shiratani,Yuki Nagashima,Juntaro Maruyama,Yasuhiro Shiga,Kazuhide Inage,Yawara Eguchi,Sumihisa Orita,Seiji Ohtori
Accurately predicting functional outcomes in patients with spinal cord injury (SCI) helps clinicians set realistic functional recovery goals and improve the home environment after discharge. The present study aimed to develop and validate machine learning (ML) models to predict functional outcomes in patients with SCI and deploy the models within a web application. The study included data from the
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Late Blood Levels of Neurofilament Light Correlate With Outcome in Patients With Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-27 Juho Tuure,Mehrbod Mohammadian,Olli Tenovuo,Kaj Blennow,Iftakher Hossain,Peter Hutchinson,Henna-Riikka Maanpää,David K Menon,Virginia F Newcombe,Riikka S K Takala,Jussi Tallus,Mark van Gils,Henrik Zetterberg,Jussi P Posti
Neurofilament light (NF-L) is an axonal protein that has shown promise as a traumatic brain injury (TBI) biomarker. Serum NF-L shows a rather slow rise after injury, peaking after 1-2 weeks, although some studies suggest that it may remain elevated for months after TBI. The aim of this study was to examine if plasma NF-L levels several months after the injury correlate with functional outcome in patients
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Standing reactive postural responses of lower limbs with and without self-balance assistance in individuals with spinal cord injury receiving epidural stimulation. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-27 Collin D Bowersock,Tanvi Pisolkar,Xupeng Ai,Chenfei Zhu,Claudia Angeli,Susan J Harkema,Gail F Forrest,Sunil Agrawal,Enrico Rejc
Spinal cord epidural stimulation can promote the recovery of motor function in individuals with severe spinal cord injury (SCI) by enabling the spinal circuitry to interpret sensory information and generate related neuromuscular responses. This approach enables the spinal cord to generate lower limb extension patterns during weight bearing, allowing individuals with SCI to achieve upright standing
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Intracranial Pressure-Derived Cerebrovascular Reactivity Indices and Their Critical Thresholds: A Canadian High Resolution-Traumatic Brain Injury Validation Study. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-22 Kevin Y Stein,Logan Froese,Mypinder Sekhon,Donald Griesdale,Eric P Thelin,Rahul Raj,Jeanette Tas,Marcel Aries,Clare Gallagher,Francis Bernard,Alwyn Gomez,Andreas H Kramer,Frederick A Zeiler
Current neurointensive care guidelines recommend intracranial pressure (ICP) and cerebral perfusion pressure (CPP) centered management for moderate-severe traumatic brain injury (TBI) because of their demonstrated associations with patient outcome. Cerebrovascular reactivity metrics, such as the pressure reactivity index (PRx), pulse amplitude index (PAx), and RAC index, have also demonstrated significant
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Response to Zanier and Citerio, "Evaluating a Pupillometry App Considering Sedation's Impact: A Step Unexplored" (doi: 10.1089/neu.2023.0431). J. Neurotrauma (IF 4.2) Pub Date : 2023-11-20 Anthony J Maxin,Bernice G Gulek,Chungeun Lee,Do Lim,Alex Mariakakis,Michael R Levitt,Lynn B McGrath
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A Perspective on Hormonal Contraception Usage in Central Nervous System Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-17 Hari Pradhyumnan,Gina G Perez,Shahil H Patel,Meghan O Blaya,Helen M Bramlett,Ami Raval
Naturally occurring life stages in women are associated with changes in the milieu of endogenous ovarian hormones. Women of childbearing age may be exposed to exogenous ovarian hormone(s) due to their use of varying combinations of estrogen and progesterone hormones-containing oral contraceptives (OC; also known as "the pill"). If women suffer central nervous system (CNS) injury such as spinal cord
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Intimate partner violence and other trauma exposures in females with traumatic brain injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-17 Nicola L de Souza,Raj Kumar,Ariel Pruyser,Emily Blunt,William Sanders,Anogue Meyden,Phoebe Lawrence,Umesh Venkatesan,Christine MacDonald,Jeanne M Hoffman,Yelena G Bodien,Brian L Edlow,Kristen Dams-O'Connor
We examined whether females with a history of traumatic brain injury (TBI) and intimate partner violence (IPV) have greater exposure to lifetime trauma relative to females with TBI but no IPV history. Further, we assessed the effects of lifetime trauma on psychological outcomes following TBI. Female participants (n=70; age M(SD)= 50.5(15.2) years) with TBI (time since injury median (IQR)= 10.2 (5.3-17
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Temporal Profiles of P-Tau, T-Tau, and P-Tau:Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6-12 Month Global Outcomes. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-16 Richard Rubenstein,Leah McQuillan,Kevin K W Wang,Claudia Robertson,Binggong Chang,Zhihui Yang,Haiyan Xu,John Williamson,Amy K Wagner
Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to increased risk of neurodegenerative diseases known as "tauopathies." Increased post-TBI tau hyperphosphorylation has been reported in brain tissue and biofluids. Acute-to-chronic TBI total (T)-tau and phosphorylated (P)-tau temporal profiles in the cerebrospinal fluid (CSF) and serum and their relationship to
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White Matter Organization and Cortical Thickness Differ Among Active Duty Service Members With Chronic Mild, Moderate, and Severe Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-15 Sarah I Gimbel,Lars D Hungerford,Elizabeth W Twamley,Mark L Ettenhofer
Abstract This study compared findings from whole-brain diffusion tensor imaging (DTI) and volumetric magnetic resonance imaging (MRI) among 90 Active Duty Service Members with chronic mild traumatic brain injury (TBI; n = 52), chronic moderate-to-severe TBI (n = 17), and TBI-negative controls (n = 21). Data were collected on a Philips Ingenia 3T MRI with DTI in 32 directions. Results demonstrated that
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Protective effects of Hinokitiol on neuronal ferroptosis by activating the KEAP1/NRF-2/HO-1 pathway in traumatic brain injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-14 Hongxing Tang,Kejun He,Kun Zhao,Chen Zheng,Weichi Wu,Weilin Jin,Lixuan Yang,Baoshu Xie
Hinokitiol (β-thujaplicin, HIK) is a natural monoterpene small molecule compound showing various biological effects including antibacterial, anti- inflammatory and anti-tumor. Ferroptosis, a new form of iron-dependent cell death, has been demonstrated as one of the pathophysiological mechanisms of traumatic brain injury (TBI). However, the effect of hinokitiol on neuronal ferroptosis after traumatic
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Spreading Depolarizations Contribute to the Acute Behavior Deficits Associated With a Mild Traumatic Brain Injury in Mice. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-14 Natalie J Pinkowski,Betty Fish,Carissa J Mehos,Victoria L Carlson,Brandi R Hess,Andrew R Mayer,Russell A Morton
Concussions or mild traumatic brain injuries (mTBIs) are often described and diagnosed by the acute signs and symptoms of neurological dysfunction including weakness, dizziness, disorientation, headaches, and altered mental state. The cellular and physiological mechanisms of neurological dysfunction and acute symptoms are unclear. Spreading depolarizations (SDs) occur after severe TBIs and have recently
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Automatic Quantification of Enlarged Perivascular Space in Patients with Traumatic Brain Injury Using Super-resolution of T2-weighted Images. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-11 Jiachen Zhuo,Prashant Raghavan,Muhan Shao,Steven R Roys,Xiao Liang,Rosy Linda Njonkou Tchoquessi,Chandler Sours Rhodes,Neeraj Badjatia,Jerry Prince,Rao P Gullapalli
The perivascular space (PVS) is important to brain waste clearance and brain metabolic homeostasis. Enlarged PVS (ePVS) becomes visible on MRI and is best appreciated on T2-weighted (T2w) images. Quantification of ePVS is however challenging because standard-of-care T1-weighted (T1w) and T2w images are often obtained as 2D acquisition, whereas accurate quantification of ePVS normally requires high-resolution
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Neurological effects of repeated blast exposure in Special Operations personnel. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-11 James R Stone,Brian B Avants,Nicholas Tustison,Jessica Gill,Elisabeth A Wilde,Kiel D Neumann,Leslie A Gladney,Madison O Kilgore,F Bowling,Christopher M Wilson,John F Detro,Heather Belanger,Katryna Deary,Hans Linsenbardt,Stephen Ahlers
Exposure to blast overpressure has been a pervasive feature of combat-related injuries. Studies exploring the neurological correlates of repeated low-level blast exposure in career Breachers demonstrated higher levels of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6) and decreases in interleukin-10 (IL-10) within brain-derived extracellular vesicles (BDEVs). The current pilot study was
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Contrasting Experimental Rodent Aftercare With Human Clinical Treatment for Cervical Spinal Cord Injury: Bridging the Translational "Valley of Death". J. Neurotrauma (IF 4.2) Pub Date : 2023-11-10 Aaron L Silverstein,Katelyn G Lawson,H Francis Farhadi,Warren J Alilain
More than half of all spinal cord injuries (SCIs) occur at the cervical level and often lead to life-threatening breathing motor dysfunction. The C2 hemisection (C2Hx) and high cervical contusion mouse and rat models of SCI are widely utilized both to understand the pathological effects of SCI and to develop potential therapies. Despite rigorous research effort, pre-clinical therapeutics studied in
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Higher regional grey matter volume and white matter integrity in individuals with central neuropathic pain following spinal cord injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-08 Abigail Livny,Yael Golan,Nofar Itzhaki,Dafna Grosberg,Galia Tsarfaty,Moshe Bondi,Gabi Zeilig,Ruth Defrin
Spinal cord injury (SCI) is a debilitating neurological condition that often leads to central neuropathic pain (CNP). As the fundamental mechanism of CNP is not fully established, its management is one of the most challenging problems among people with SCI. In order to shed more light on CNP mechanisms, the aim of the current study was to compare the brain structure between individuals with SCI and
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Blast-Induced Central Auditory Neurodegeneration Affects Tinnitus Development Regardless of Peripheral Cochlear Damage. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-08 Takaomi Kurioka,Kunio Mizutari,Yasushi Satoh,Yasushi Kobayashi,Akihiro Shiotani
Blast exposure causes serious complications, the most common of which are ear-related symptoms such as hearing loss and tinnitus. The blast shock waves can cause neurodegeneration of the auditory pathway in the brainstem, as well as the cochlea, which is the primary receptor for hearing, leading to blast-induced tinnitus. However, it is still unclear which lesion is more dominant in triggering tinnitus
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Metabotropic glutamate receptor 2 expression is chronically elevated in male rats with post-traumatic stress disorder related behavioral traits following repetitive low-level blast exposure. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-02 Rita De Gasperi,Miguel A Gama Sosa,Georgina Perez Garcia,Gissel Perez,Dylan Pryor,Chenel Lori-Ann Morrison,Rachel Lind,Rania Abutarboush,Usmah Kawoos,Jonathan Keegan Statz,Jacob Patterson,Patrick Hof,Carolyn W Zhu,Stephen Ahlers,David Cook,Gregory A Elder
Many military veterans who have experienced blast-related traumatic brain injuries in the conflicts in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop cognitive and PTSD-related behavioral traits that are present for more than one year after
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Prognostic and Diagnostic Utility of Serum Biomarkers in Pediatric Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-02 Jennifer C Munoz Pareja,Juan Pablo de Rivero Vaccari,Maria Mateo Chavez,Maria Kerrigan,Charlene Pringle,Kourtney Guthrie,Kathryn Swaby,Jennifer Coto,Firas Kobeissy,K Leslie Avery,Suman Ghosh,Dhanashree Rajderkar,Prashanth Shanmugham,Lauren A Lautenslager,Shannon Faulkenberry,Maria C Pareja Zabala,Nora AlFakhri,Ricardo Loor-Torres,Lance S Governale,Jason E Blatt,Joslyn Gober,Paula Karina Perez,Juan
Traumatic brain injury (TBI) remains a major cause of morbidity and death among the pediatric population. Timely diagnosis, however, remains a complex task because of the lack of standardized methods that permit its accurate identification. The aim of this study was to determine whether serum levels of brain injury biomarkers can be used as a diagnostic and prognostic tool in this pathology. This prospective
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Chemogenetic attenuation of acute nociceptive signaling enhances functional outcomes following spinal cord injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-31 Prakruthi Amar Kumar,Jacob Stallman,Yahya Kharbat,Joseph Hoppe,Amy Leonards,Ethan Kerim,Britney Nguyen,Robert L Adkins,Angelina Baltazar,Sara Milligan,Sunjay Letchuman,Michelle A Hook,Jennifer Dulin
Identifying novel therapeutic approaches to promote recovery of neurological functions following spinal cord injury (SCI) remains a great unmet need. Nociceptive signaling in the acute phase of SCI has been shown to inhibit recovery of locomotor function and promote the development of chronic neuropathic pain. We therefore hypothesized that inhibition of nociceptive signaling in the acute phase of
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Repeated mild concussive events heighten the vulnerability of brain to blast exposure. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-31 Peethambaran Arun,Jishnu Krishnan,Manoj Govindarajulu,Donna M Wilder,Joseph B Long
Mild concussive events without loss of consciousness are typically left untreated and can result in neurological abnormalities at later stages of life. No systematic studies have been carried out to determine the effect of concussion or repeated mild concussive episodes on brain vulnerability towards blast exposure. We have evaluated the effect of repeated mild concussive events on the vulnerability
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Evaluating a Pupillometry App Considering Sedation's Impact: A Step Unexplored. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-30 Elisa R Zanier,Giuseppe Citerio
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Microstructural Organization of Distributed White Matter Associated With Fine Motor Control in US Service Members With Mild Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-27 Benjamin S C Wade,David F Tate,Eamonn Kennedy,Erin D Bigler,Gerald E York,Brian A Taylor,Maya Troyanskaya,Elizabeth S Hovenden,Naomi Goodrich-Hunsaker,Mary R Newsome,Emily L Dennis,Tracy Abildskov,Mary Jo Pugh,William C Walker,Kimbra Kenney,Aaron Betts,Robert Shih,Robert C Welsh,Elisabeth A Wilde
Mild traumatic brain injury (mTBI) is the most common form of brain injury. While most individuals recover from mTBI, roughly 20% experience persistent symptoms, potentially including reduced fine motor control. We investigate relationships between regional white matter organization and subcortical volumes associated with performance on the Grooved Pegboard (GPB) test in a large cohort of military
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Dynamic Relations Between Psychological Resilience and Post-Concussion Symptoms in Children With Mild Traumatic Brain Injury Versus Orthopedic Injury: An A-CAP Study. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-27 Ali Hassan,Brian L Brooks,Brae Anne McArthur,Miriam H Beauchamp,William Craig,Quynh Doan,Roger Zemek,Keith Owen Yeates
Higher psychological resilience is correlated with less severe post-concussion symptoms (PCS) after mild traumatic brain injury (mTBI) in children, but the directional nature of this relationship remains uncertain. Although traditionally regarded as a stable, trait-like construct, resilience may be malleable and potentially influenced by mTBI and post-concussive symptoms. The current study sought to
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Evidence of ongoing cerebral microstructural reorganization in children with persisting symptoms following mild traumatic brain injury: a NODDI DTI analysis. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-26 Athena Stein,Xuan Vinh To,Fatima Nasrallah,Karen Maria Barlow
INTRO Approximately 300 to 550 children per 100,000 sustain a mild traumatic brain injury (mTBI) each year, where about 25-30% have long-term cognitive problems. Following mTBI, free water (FW) accumulation occurs in white matter (WM) tracts. Diffusion tensor imaging (DTI) can be used to investigate structural integrity following mTBI. Compared to conventional DTI, NODDI orientation dispersion index
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Characterization of sleep, emotional and cognitive functions in a new rat model of concomitant spinal cord and traumatic brain injuries. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-26 Morgane Regniez,Julien Dufort-Gervais,Chloé Provost,Valérie Mongrain,Marina Martinez
Traumatic injuries to the spinal cord or the brain have serious medical consequences and lead to long-term disability. The epidemiology, medical complications, and prognosis of isolated spinal cord injury (SCI) and traumatic brain injury (TBI) have been well described. However, there are limited data on patients suffering from concurrent SCI and TBI, even if a large proportion of SCI patients have
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Experimental Models of Hospital-Acquired Infections after Traumatic Brain Injury: Challenges and Opportunities. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-26 Natasha Gandasasmita,Jian Li,David J Loane,Bridgette D Semple
Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased risk of nosocomial infections, including bacterial pneumonia and other upper respiratory tract infections. Infections represent a secondary immune challenge for vulnerable TBI patients that can lead to increased morbidity and poorer long-term prognosis. This review first describes the clinical significance
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Early life stress negatively impacts spatial learning acquisition and increases hippocampal CA1 microglial activation after a mild traumatic brain injury in adult male rats. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-26 Ana Fernanda Salinas-García,Angelica Roque,Jonathan Josué Zamudio-Flores,Esperanza Meléndez-Herrera,Anthony E Kline,Naima Lajud
Early life stress (ELS) affects neurogenesis, cognitive performance, and increases neuroinflammation after a pediatric mild traumatic brain injury (mTBI). Previous studies have shown that ELS has minimal effects in juveniles, but it shows an age-dependent effect in adults. Hence, we aimed to evaluate if ELS affects cognitive performance, hippocampal microglial activation, and neurogenesis after a mTBI
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Understanding the Relationships Between Sleep Quality and Depression and Anxiety in Neurotrauma: A Scoping Review. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-25 Krisha Saravanan,Luke Downey,Abbey Sawyer,Melinda L Jackson,David J Berlowitz,Marnie Graco
Sleep problems, depression, and anxiety are highly prevalent after a spinal cord injury (SCI) and traumatic brain injury (TBI) and may worsen functional outcomes and quality of life. This scoping review examined the existing literature to understand the relationships between sleep quality, depression, and anxiety in persons with SCI and TBI, and to identify gaps in the literature. A systematic search
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Outlier Analysis for Acute Blood Biomarkers of Moderate and Severe Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-19 Otto Korhonen,Malla Mononen,Mehrbod Mohammadian,Olli Tenovuo,Kaj Blennow,Iftakher Hossain,Peter Hutchinson,Henna-Riikka Maanpää,David K Menon,Virginia F Newcombe,Jean-Charles Sanchez,Riikka S K Takala,Jussi Tallus,Mark van Gils,Henrik Zetterberg,Jussi P Posti
Blood biomarkers have been studied to improve the clinical assessment and prognostication of patients with moderate-severe traumatic brain injury (mo/sTBI). To assess their clinical usability, one needs to know of potential factors that might cause outlier values and affect clinical decision making. In a prospective study, we recruited patients with mo/sTBI (n = 85) and measured the blood levels of
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Response to Folweiler KA et al., Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes With Distinct Acute Injury Profiles and Long-Term Outcomes (DOI: 10.1089/neu.2019.6705). J. Neurotrauma (IF 4.2) Pub Date : 2023-10-18 Ching-Ying Wang,Jau-Ching Wu,Yi-Hsuan Kuo
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Temporal Changes in Fixational Eye Movements After Concussion in Adolescents and Adults: Preliminary Findings. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-17 Ted J Albrecht,Bindal Makwana Mehmel,Ethan A Rossi,Alicia M Trbovich,Shawn R Eagle,Anthony P Kontos
Concussions often involve ocular impairment and symptoms such as convergence insufficiency, accommodative insufficiency, blurred vision, diplopia, eye strain, and pain. Current clinical assessments of ocular function and symptoms rely on subjective symptom reporting and/or involve lengthy administration time. More objective, brief assessments of ocular function following concussion are warranted. The
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Covert Tracking to Immersive Stimuli in Traumatic Brain Injury Subjects With Disorders of Consciousness. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-16 Gabriela Aklepi,Brian Manolovitz,Linda E Robayo,Amin Sarafraz,Carlos Francisco Blandino,Brian Arwari,Evie Sobczak,Danielle Bass,Pardis Ghamasaee,Ana Bolaños Saavedra,Daniel Samano,Nina Massad,Mohan Kottapally,Amedeo Merenda,Salim Dib,W Dalton Dietrich,Tatjana Rundek,Kristine H O'Phelan,Jan Claassen,Mark F Walker,Ayham Alkhachroum
Eye tracking assessments are clinician dependent and can contribute to misclassification of coma. We investigated responsiveness to videos with and without audio in traumatic brain injury (TBI) subjects using video eye-tracking (VET). We recruited 20 healthy volunteers and 10 unresponsive TBI subjects. Clinicians were surveyed whether the subject was tracking on their bedside assessment. The Coma Recovery
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Applying the Sliding Scale Approach to Quantifying Functional Outcomes Up to Two Years After Severe Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-16 Shawn R Eagle,Enyinna Nwachuku,Hansen Deng,David O Okonkwo,Justin Elmer,Matthew Pease
Outcomes after severe traumatic brain injury (TBI) can be represented by a sliding score that compares actual functional recovery to that predicted by illness severity models. This approach has been applied in clinical trials because of its statistical efficiency and interpretability but has not been used to describe change in functional recovery over time. The objective of this study was to use a
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Attenuated tissue damage with Mechanical Tissue Resuscitation in a pig model of spinal cord injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-13 Zhenlin Zheng,Daniel Couture,Farren Adams,Rebecca Roberson,Rong Ma,Louis Argenta,Michael Morykwas
Our previous studies on the treatment of spinal cord injuries with Mechanical Tissue Resuscitation (MTR) in rats have demonstrated that it can significantly improve the locomotor recovery and BBB scores. MTR treatment also reduced fluid accumulations by T2-imaging and improved the mean neural fiber number and fiber length in injured sites by fiber tractography. Myelin volume was also significantly
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Post-Concussion Symptoms in Women With Head Injury Due to Intimate Partner Violence. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-13 Justin E Karr,T K Logan
Limited research has examined the symptom sequelae of head injuries in women survivors of intimate partner violence (IPV), despite this community being at increased risk for neurotrauma due to partner abuse. The current study compared post-concussion symptom severity between women with and without IPV-related head injuries. Women were recruited from court jurisdictions in Kentucky, USA, after receiving
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Serum Caffeine Concentration at the Time of Traumatic Brain Injury and Its Long-Term Clinical Outcomes. J. Neurotrauma (IF 4.2) Pub Date : 2023-10-12 Hanna Yoon,Young Sun Ro,Eujene Jung,Sung Bae Moon,Gwan Jin Park,Stephen Gyung Won Lee,Sang Do Shin
Caffeine is one of the most widely consumed psychoactive drugs in the general population. It has a neuroprotective effect in degenerative neurological disorders; however, the association between caffeine and traumatic brain injury (TBI) outcomes is contradictory. The objective of this study was to evaluate the association between serum caffeine concentration at the time of injury and long-term functional
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How Severe Is Severe Disability After Traumatic Brain Injury? Response to Sarigul B et al., Prognostication and goals of care decisions in Severe traumatic brain injury: A survey of the Seattle International Severe Traumatic Brain Injury Consensus Conference Working Group (DOI: 10.1089/neu.2022.0414). J. Neurotrauma (IF 4.2) Pub Date : 2023-10-12 Yelena G Bodien,Cynthia L Beaulieu,Joseph T Giacino,Alan Weintraub,John Whyte,Michael W Williams
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Application of delayed contrast extravasation MRI for depicting subtle blood-brain barrier disruption in a traumatic brain injury model. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-30 Sigal Liraz-Zaltsman,Shirley Sharabi,David Guez,Dianne Daniels,Itzik Cooper,Chen Shemesh,Dana Atrakchi,Orly Ravid,Liora Omesi,Daniel Rand,Livny Abigail LivnyEzer,Michal Schnaider Beeri,Yael Friedman Levi,Esther Shohami,Yael Mardor,David Last
BACKGROUND The blood-brain barrier (BBB) is composed of brain microvasculature that provides selective transport of solutes from the systemic circulation into the central nervous system to protect the brain and spinal microenvironment. Damage to the BBB in the acute phase following traumatic brain injury (TBI) is recognized as a major underlying mechanism leading to secondary long-term damage. However
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Characterization of Vasogenic and Cytotoxic Brain Edema Formation after experimental TBI by Free Water Diffusion MRI. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-30 Senbin Hu,Carina Exner,Rebecca Isabella Sienel,Antonia Wehn,Burcu Seker,Fanni Magdane Boldoczki,Yinghuimin Guo,Marco Duering,Ofer Pasternak,Nikolaus Plesnila,Susanne M Schwarzmaier
Brain edema formation is a key factor for secondary tissue damage after traumatic brain injury (TBI). While vasogenic brain edema (VBE) is caused by blood brain barrier disruption, cytotoxic edema (CBE) is caused by astrocytic swelling. However, the type of brain edema and the time course of edema formation remain unclear. We performed free water imaging, a bi-tensor model based diffusion MRI analysis
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Predicting the Progression of Spasticity in the Early Phase of Spinal Cord Injury: A Prospective Cohort Study. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-22 Kazuya Yokota,Osamu Kawano,Hiroaki Sakai,Yuichiro Morishita,Muneaki Masuda,Tetsuo Hayashi,Kensuke Kubota,Ryosuke Ideta,Yuto Ariji,Ryuichiro Koga,Satoshi Murai,Ryusei Ifuku,Masatoshi Uemura,Hiroyuki Katoh,Yasuharu Nakashima,Takeshi Maeda
Spasticity-defined as involuntary movements caused by insult to upper motor neurons after spinal cord injury (SCI)-interferes with patients' activities of daily living. Spasticity is generally identified and managed in the chronic phase of SCI, but few reports have examined the onset of spasticity after injury. The purpose of this study is to elucidate serial changes in spasticity after SCI and clarify
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Differences in Anatomical Outcomes Between Early Chronic and Far Chronic Time-Points After Transplantation of Spinal Cord Neural Progenitor Cells in Mice. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-28 Angelina Baltazar,Ashley Tucker,Julius Jang,Katie Vo,Jennifer N Dulin
Spinal cord injury (SCI) affects millions of people worldwide. Neural progenitor cell (NPC) transplantation is a promising treatment for regenerating lost spinal cord tissue and restoring neurological function after SCI. We conducted a literature search and found that less than a quarter of experimental rodent cell and tissue transplantation studies have investigated anatomical outcomes at longer than
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Mild Traumatic Brain Injury and the Auditory System: An Overview of the Mechanisms, Clinical Presentations and Current Diagnostic Modalities. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-24 Mark Harris,Andrew Nguyen,Nolan J Brown,Bryce Picton,Julian Gendreau,Nicholas Bui,Ronald Sahyouni,Harrison W Lin
The acute and long-term consequences of mild traumatic brain injury (mTBI) are far reaching. Though it may often be overlooked due to the now expansive field of research dedicated to understanding the consequences of mTBI on the brain, recent work has revealed that substantial changes in the vestibulo-auditory system can also occur due to mTBI. These changes, termed "labyrinthine" or "cochlear concussion"
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Collaborative Care versus Usual Care to Improve Quality of Life, Pain, Depression, and Physical Activity in Outpatients with Spinal Cord Injury: The SCI-CARE Randomized Controlled Clinical Trial. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-22 Charles H Bombardier,Jesse R Fann,Dawn M Ehde,Maria R Reyes,Stephen P Burns,Jason K Barber,Nancy R Temkin
Our goal was to test the effectiveness of collaborative care (CC) versus usual care (UC) to improve treatment of pain, depression, physical inactivity, and quality of life in outpatients with spinal cord injury (SCI). We conducted a single blind parallel group randomized controlled trial. The setting was two outpatient SCI rehabilitation clinics within a large academic medical center. Participants
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Reduced Neuroinflammation Via Astrocytes and Neutrophils Promotes Regeneration After Spinal Cord Injury in Neonatal Mice. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-20 Kazuki Kitade,Kazu Kobayakawa,Hirokazu Saiwai,Yoshihiro Matsumoto,Kenichi Kawaguchi,Keiichiro Iida,Ken Kijima,Hirotaka Iura,Tetsuya Tamaru,Yohei Haruta,Gentaro Ono,Daijiro Konno,Takeshi Maeda,Seiji Okada,Kinichi Nakashima,Yasuharu Nakashima
Neonatal spinal cord injury (SCI) shows better functional outcomes than adult SCI. Although the regenerative capability in the neonatal spinal cord may have cues in the treatment of adult SCI, the mechanism underlying neonatal spinal cord regeneration after SCI is unclear. We previously reported age-dependent variation in the pathogenesis of inflammation after SCI. Therefore, we explored differences
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Sex- and Age-Related Differences in Post-Concussive Symptom Reporting Among Children and their Parents. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-19 Andrew Mayer,Jessica R McQuaid,Tracey V Wick,Andrew Burke Dodd,Cidney Robertson-Benta,David Stephenson,Harm J van der Horn,Davin Quinn,William A Davis,Anne K Hittson,Robert Sapien,John Phillips,Richard Campbell
Pediatric mild traumatic brain injury (pmTBI) has received increased public attention over the past decade, especially for children who experience persistent post-concussive symptoms (PCS). Common methods for obtaining pediatric PCS rely on both self- and parental report, exhibit moderate test-retest reliability, variable child-parent agreement and may yield high false positives. The current study
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Adaptation and validation of the Standardized Swallowing Assessment tool for patients with moderate-severe brain injury and cervical spinal cord injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-19 Melanie Berube,Simon Ouellet,Valérie Turcotte,Annick Gagné,Céline Gélinas
Oropharyngeal dysphagia is common in moderate-severe traumatic brain injury (TBI) and cervical spinal cord injury (SCI) patients and can have serious consequences. Delaying feeding in these patients can also be detrimental. Nonetheless, the psychometric properties of screening tools that can promptly identify dysphagia have never been tested in these neurotrauma populations. This study aimed to: 1)
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Exercise Intolerance After Mild Traumatic Brain Injury Occurs in All Subtypes in the Adult Population. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-15 Prokopios Antonellis,Kody R Campbell,Jennifer L Wilhelm,Jesse D Shaw,James C Chesnutt,Laurie A King
Thematically grouped symptom clusters are present during the acute timeline of post-mild traumatic brain injuries (mTBI), representing clinical profiles called subtypes. Exercise intolerance has not been evaluated within the subtype classifications and, because guidelines support early submaximal aerobic exercise, further knowledge is required in regard to the exercise capabilities among the concussion
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Neighborhood Disadvantage and Clinical Outcome Following Concussion in Adolescents. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-14 Charles E Gaudet,Nathan E Cook,Alicia Kissinger-Knox,Brian Liu,Katie Stephenson,Paul D Berkner,Grant L Iverson
Whether social determinants of health are associated with clinical outcome following concussion among adolescents is not well established. The present study examined whether neighborhood-level determinants are associated with clinical recovery time following concussion in adolescents. Participants included adolescent student athletes (n = 130; mean age = 16.6, standard deviation = 1.2; 60.8% boys,
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Repeated Mild Traumatic Brain Injury and JZL184 Produce Sex-Specific Increases in Anxiety-Like Behavior and Alcohol Consumption in Wistar Rats. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-12 Alejandra Jacotte-Simancas,Patricia E Molina,Nicholas W Gilpin
Alcohol use disorder (AUD) is highly comorbid with traumatic brain injury (TBI). Previously, using a lateral fluid percussion model (LFP) (an open-head injury model) to generate a single mild to moderate traumatic brain injury (TBI) we showed that TBI produces escalation in alcohol drinking, that alcohol exposure negatively impacts TBI outcomes, and that the endocannabinoid degradation inhibitor (JZL184)
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Adverse Effect of Neurogenic, Infective, and Inflammatory Fever on Acutely Injured Human Spinal Cord. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-12 Ravindran Visagan,Siobhan Kearney,Christian Blex,Leonarda Serdani-Neuhaus,Marcel A Kopp,Jan M Schwab,Argyro Zoumprouli,Marios C Papadopoulos,Samira Saadoun
This study aims to determine the effect of neurogenic, inflammatory, and infective fevers on acutely injured human spinal cord. In 86 patients with acute, severe traumatic spinal cord injuries (TSCIs; American Spinal Injury Association Impairment Scale (AIS), grades A-C) we monitored (starting within 72 h of injury, for up to 1 week) axillary temperature as well as injury site cord pressure, microdialysis
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Epidemiology of Gunshot-Related Spinal Injuries and Related Risk Factors for In-Hospital Mortality in the United States from 2015-2019: A National Trauma Data Bank Analysis. J. Neurotrauma (IF 4.2) Pub Date : 2023-11-21 Brandon A Sherrod,Jason B Young,Christopher G Wilkerson,Erica F Bisson,Andrew T Dailey,Marcus D Mazur
Firearm injuries in the U.S. pose a significant public health burden, but data on gunshot wounds (GSWs) specifically involving the spine are scarce. We examined epidemiological trends in GSWs to the spine and associated spinal cord injury (SCI) and mortality rates. This was a cross-sectional study of data from level I-III trauma centers in the U.S. participating in the American College of Surgeons
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Repetitive Head Injury and Cognitive, Physical, and Emotional Symptoms in Women Survivors of Intimate Partner Violence. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-11 Justin Elliott Karr,Sharon E Leong,Eric O Ingram,T K Logan
Many women survivors of intimate partner violence (IPV) experience repetitive head injuries in their lifetime, but limited research has examined the cumulative effects of multiple head injuries on post-concussion symptom severity in this population. This study examined how number of lifetime head injuries and episodes of loss of consciousness (LOC) due to head injuries were related to current cognitive
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Cumulative Blast Exposure During a Military Career Negatively Impacts Recovery from Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-07 Jason Bailie,Sara Lippa,Lars Hungerford,Louis M French,Tracey A Brickell,Rael T Lange
Sub-concussive injuries have emerged as an important factor in the long-term brain health of athletes and military personnel. The objective of this study was to explore the relationship between service member and veteran's (SMVs) lifetime blast exposure and recovery from a traumatic brain injury (TBI). 558 SMVs with a history of TBI were examined. Lifetime blast exposure (LBE) was based on self-report
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SURGICAL OUTCOMES IN POST-TRAUMATIC TEMPORAL LOBE EPILEPSY: A SYSTEMATIC REVIEW AND META-ANALYSIS. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-02 Liam David Ferreira,Mohammad Tabaeizadeh,Zulfi Haneef
Epilepsy surgery provides excellent benefits in PTE-TL, but outcomes relative to NTE-TL are less favorable. Large well-designed studies are recommended to further clarify the role of epilepsy surgery in PTE. It is unclear whether epilepsy surgery outcomes in post-traumatic epilepsy (PTE) are as robust as described for drug resistant epilepsy (DRE) in general . Prior outcome studies in PTE are limited
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An Introduction to the North American Clinical Trials Network for Spinal Cord Injury Special Edition: Reflections on Accomplishments and a Look to the Future. J. Neurotrauma (IF 4.2) Pub Date : 2023-09-01 Michael G Fehlings,Chris J Neal,Nader Hejrati,James S Harrop,Elizabeth G Toups,James D Guest
The North American Clinical Trials Network (NACTN) has been established as a network of translational clinical research centers focused on traumatic spinal cord injury (SCI) with the goals of facilitating clinical translational research, promotion of enhanced clinical care protocols including the principle of early surgery for SCI, and improving outcomes for individuals with acute SCI. Since its foundation
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High Lifetime Blast Exposure using the Blast Exposure Threshold Survey is Associated with Worse Warfighter Brain Health following Mild Traumatic Brain Injury. J. Neurotrauma (IF 4.2) Pub Date : 2023-08-31 Rael T Lange,Louis M French,Sara M Lippa,Kelly Gillow,Corie Tippett,Elizabeth Barnhart,Megan Glazer,Jason Bailie,Lars Hungerford,Tracey A Brickell
The purpose of this study was to extend previous research by examining the relationship between lifetime blast exposure (LBE) and neurobehavioral functioning following mild TBI (MTBI) by using a comprehensive measure of lifetime blast exposure. Participants were 103 United States SMVs with a medically documented diagnosis of MTBI, recruited from three military treatment facilities (74.8%) and community-based
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Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice. J. Neurotrauma (IF 4.2) Pub Date : 2023-08-30 Rebecca T Somach,Ian D Jean,Anthony M Farrugia,Akiva S Cohen
Traumatic brain injury (TBI) is known to affect the physiology of neural circuits in several brain regions, which can contribute to behavioral changes after injury. Disordered sleep is a behavior that is often seen after TBI, but there is little research into how injury affects the circuitry that contributes to disrupted sleep regulation. Orexin/hypocretin neurons (hereafter referred to as orexin neurons)