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Extracellular acidification attenuates bronchial contraction via an autocrine activation of EP2 receptor: its diminishment in murine experimental asthma Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-03-14 Yoshihiko Chiba, Yamato Yamane, Tsubasa Sato, Wataru Suto, Motohiko Hanazaki, Hiroyasu Sakai
Extracellular acidification is a major component of tissue inflammation, including airway inflammation in asthmatics. However, its physiological/pathophysiological significance in bronchial function is not fully understood. Currently, the functional role of extracellular acidification on bronchial contraction was explored. Left main bronchi were isolated from male BALB/c mice. Epithelium-removed tissues
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Analyzing key elements of breathing patterns, deriving remaining variables, and identifying cutoff values in individuals with chronic respiratory disease and healthy subjects Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-03-02 Ming-Lung Chuang
Pulmonary physiology encompasses intricate breathing patterns (BPs), characterized by breathing frequency (Bf), volumes, and flows. The complexities intensify in the presence of interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD), especially during exercise. This study seeks to identify pivotal factors driving changes among these variables and establish cutoff values, comparing
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USING THE GLI SPIROGRAPHIC PREDICTION EQUATIONS TO REVISIT THE ALLOMETRIC RELATIONSHIPS BETWEEN LUNG VOLUMES, HEIGHT AND AGE IN ADULTS Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-03-01 Philippe HAOUZI, Sairam RAGHAVAN, Jonathan McCully
The determination the forced vital capacity (FVC) and the forced expiratory volume in 1second (FEV1) during spirometry studies, is at the core of the evaluation of the pulmonary function of patients with respiratory diseases. The Global Lung Function Initiative (GLI) offers the most extensive data set of normal lung functions available, which is currently used to determine the average expected/predicted
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Isoproterenol modulates expiratory activities in the brainstem spinal cord preparation in neonatal mice in vitro Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-26 Jean-Charles Viemari
Motor behaviors such as breathing required temporal coordination of different muscle groups to insured efficient ventilation and provide oxygen to the body. This action is the result of interactions between neural networks located within the brainstem. Inspiration and expiration depend at least in part on interactions between two separate oscillators: inspiration is driven by a neural network located
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Preventive effects of hesperidin in an experimental model ofs acute lung inflammation Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-26 Ana Beatriz Farias de Souza, Natália Alves de Matos, Thalles de Freitas Castro, Guilherme de Paula Costa, André Talvani, Akinori Cardozo Nagato, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
In this study, we hypothesized that long-term administration of hesperidin can modulate the inflammatory response and oxidative stress in animals submitted to mechanical ventilation (MV). Twenty-five C57BL/6 male mice were divided into 5 groups: control, MV, animals receiving hesperidin in three doses 10, 25 and 50 mg/kg. The animals received the doses of hesperidin for 30 days via orogastric gavage
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Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-22 Lorena Roberta de Souza Mendes Kawamura, Max Sarmet, Priscila Sales de Campos, Sachiko Takehara, Yasuhiro Kumei, Jorge Luis Lopes Zeredo
This study aimed to evaluate the timing and frequency of spontaneous apneas during breathing and swallowing by using cineradiography on mouse models of early/initial or late/advanced Parkinson’s disease (PD). C57BL/6 J mice received either 6-OHDA or vehicle injections into their right striatum, followed by respiratory movement recordings during spontaneous breathing and swallowing, and a stress challenge
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Skeletal muscle oxygenation and exercise intolerance in hemodialysis: Navigating toward promising horizons? Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-20 Marieta Theodorakopoulou, Afroditi Boutou, Pantelis Sarafidis
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Stress stimulation promotes the injury repair process of airway epithelial cells through the [Cl−]i−FAK signaling axis Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-12 Jia Wang, Jinhua Luo, Yanjuan Liu, Yu Jiang, Xiangping Qu, Chi Liu, Yang Xiang, Xiaoqun Qin
The airway epithelium serves as a critical interface with the external environment, making it vulnerable to various external stimuli. Airway epithelial stress acts as a catalyst for the onset of numerous pulmonary and systemic diseases. Our previous studies have highlighted the impact of acute stress stimuli, especially bacterial lipopolysaccharide (LPS) and hydrogen peroxide (HO), on the continuous
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Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-09 Lydia S. Robson, Abidan Abulimiti, Jorge Z. Granados, Ayesha N. Zia, Bryce N. Balmain, James A. Pawelczyk, Tony G. Babb
We investigated whether pediatric patients with overweight and obesity are more likely to have dyspnea compared with those who are non-overweight. We collected de-identified data from TriNetX, a global federated multicenter research database, using both the UT Southwestern Medical Center and multinational Research Networks. Our analysis focused on patients aged 8–12 years. We identified overweight
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Respiratory activity during seizures induced by pentylenetetrazole Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-01 Hanna L. Umezu, Paloma G. Bittencourt-Silva, Flávio A.G. Mourão, Fabrício A. Moreira, Márcio Flávio D. Moraes, Victor R. Santos, Glauber S.F. da Silva
This study investigated the respiratory activity in adult Wistar rats across different behavioral seizure severity induced by pentylenetetrazole (PTZ). Animals underwent surgery for electrodes implantation, allowing simultaneous EEG and diaphragm EMG (DIA) recordings and the respiratory frequency and DIA amplitude were measured. Seizures were acutely induced through PTZ injection and classified based
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Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-02-01 Antonis Elia, Matthew J. Barlow, Matthew J. Lees, Georgios Petri, Michail E. Keramidas
This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers. Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30,
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Neuroanatomical frameworks for volitional control of breathing and orofacial behaviors Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-29 Pedro Trevizan-Baú, Davor Stanić, Werner I. Furuya, Rishi R. Dhingra, Mathias Dutschmann
Breathing is the only vital function that can be volitionally controlled. However, a detailed understanding how volitional (cortical) motor commands can transform vital breathing activity into adaptive breathing patterns that accommodate orofacial behaviors such as swallowing, vocalization or sniffing remains to be developed. Recent neuroanatomical tract tracing studies have identified patterns and
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Obituary Fulvia Bongianni 1960–2023 Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-25 Donatella Mutolo, Elenia Cinelli, Tito Pantaleo
Abstract not available
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Loss-of-function of chemoreceptor neurons in the retrotrapezoid nucleus: What have we learned from it? Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-17 George M.P.R. Souza, Stephen B.G. Abbott
Central respiratory chemoreceptors are cells in the brain that regulate breathing in relation to arterial pH and PCO2. Neurons located at the retrotrapezoid nucleus (RTN) have been hypothesized to be central chemoreceptors and/or to be part of the neural network that drives the central respiratory chemoreflex. The inhibition or ablation of RTN chemoreceptor neurons has offered important insights into
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Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-18 Xuejia Han, Wensi Ding, Guiwu Qu, Youjie Li, Pingyu Wang, Jiahui Yu, Mingyue Liu, Xiulan Chen, Shuyang Xie, Jiankai Feng, Sen Xu
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Longitudinal changes in respiratory reactance in patients with COPD: associations with longitudinal change in air-trapping, exacerbations, and mortality Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-17 Yi Zhang, Naoya Tanabe, Susumu Sato, Yusuke Shiraishi, Tomoki Maetani, Ryo Sakamoto, Atsuyasu Sato, Shigeo Muro, Toyohiro Hirai
Introduction Air-trapping affects clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) and may be detected by reactance at 5 Hz (X5) on respiratory oscillometry because X5 sensitively reflects the elasticity of the chest wall, airway and lung. However, the longitudinal association between X5 and air-trapping remains to be explored. This study aimed to test whether longitudinal
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Axonal projection of the medullary expiratory neurons in the feline thoracic spinal cord Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-16 Kenta Kawamura, Kazumasa Sasaki, Sei-Ichi Sasaki, Kazuhide Tomita
Expiratory neurons in the caudal ventral respiratory group extend descending axons to the lumbar and sacral spinal cord, and they possess axon collaterals, the distribution of which has been well-documented. Likewise, these expiratory neurons extend axons to the thoracic spinal cord and innervate thoracic expiratory motoneurons. These axons also give rise to collaterals, and their distribution may
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Neural oscillations underlying the neural gating of respiratory sensations in generalized anxiety disorder Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2024-01-09 Kai-Jie Liang, Chia-Hsiung Cheng, Chia-Yih Liu, Shih-Chieh Hsu, Andreas von Leupoldt, Valentina Jelinčić, Pei-Ying S. Chan
Individuals with generalized anxiety disorder (GAD) have been shown to have altered neural gating of respiratory sensations (NGRS) using respiratory-related evoked potentials (RREP); however, corresponding neural oscillatory activities remain unexplored. The present study aimed to investigate altered NGRS in individuals with GAD using both time and time-frequency analysis. Nineteen individuals with
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Respiratory sinus arrhythmia in spontaneously breathing, unanesthetized newborn and adult Wistar rats Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-29 Nana Sato Hashizume, Yoichiro Kitajima, Ryoji Ide, Eishi Nakamura, Chikako Saiki
We examined respiratory sinus arrhythmia (RSA) and possible interaction with respiratory frequency (fR) and heart rate (HR) in spontaneously breathing, unanesthetized newborn Wistar rats (2- to 5-day-old; n = 54) and the adult rats (8-week-old; n = 34). Instantaneous heart rate (inst-HR) was calculated as the reciprocal of the inter-beat-interval. For each breath, RSA was determined as the difference
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Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-21 Rachael Herlihy, Leonardo Frasson Dos Reis, Anzor Gvritishvili, Maya Kvizhinadze, Elizabeth Dybas, Atul Malhotra, Victor B. Fenik, Irma Rukhadze
The state-dependent noradrenergic activation of hypoglossal motoneurons plays an important role in the maintenance of upper airway patency and pathophysiology of obstructive sleep apnea (OSA). Chronic intermittent hypoxia (CIH), a major pathogenic factor of OSA, contributes to the risk for developing neurodegenerative disorders in OSA patients. Using anterograde tracer, channelrhodopsin-2, we mapped
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Divergent expiratory braking activity of costal and crural diaphragm Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-21 Giovanni Tagliabue, Michael Ji, Danny J. Zuege, Paul A. Easton
Background There is increasing clinical interest in understanding the contribution of the diaphragm in early expiration, especially during mechanical ventilation. However, current experimental evidence is limited, so essential activity of the diaphragm during expiration and diaphragm segmental differences in expiratory activity, are unknown. Objectives To determine if: 1) the diaphragm is normally
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Effect of the NLRP3 inflammasome on increased hypoxic ventilation response after CIH exposure in mice Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-19 Xinyun Jia, Jianxia Sun, Qingya Zhuo, Baosheng Zhao, Yuzhen Liu
Background Chronic intermittent hypoxia (CIH) increases the hypoxic ventilation response (HVR). The downstream cytokine IL-1β of the NLRP3 inflammasome regulates respiration by acting on the carotid body (CB) and neurons in the respiratory center, but the effect of the NLRP3 inflammasome on HVR induced by CIH remains unclear. Objective To investigate the effect of NLRP3 on the increased HVR and spontaneous
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Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-14 Xuxin Chen, Fan Wang, Jian Tang, Jiguang Meng, Zhihai Han
Background Acute lung injury (ALI) involves severe lung damage and respiratory failure, which are accompanied by alveolar macrophage (AM) activation. The aim of this article is to verify the influence of paralemmin-3 (PALM3) on alveolar macrophage (AM) polarization in ALI and the underlying mechanism of action. Methods An ALI rat model was established by successive lipopolysaccharide (LPS) inhalations
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The pre-Bötzinger complex is necessary for the expression of inspiratory and post-inspiratory motor discharge of the vagus Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-02 Rishi R. Dhingra, Werner I. Furuya, Yi Kee Yoong, Mathias Dutschmann
The mammalian three-phase respiratory motor pattern of inspiration, post-inspiration and expiration is expressed in spinal and cranial motor nerve discharge and is generated by a distributed ponto-medullary respiratory pattern generating network. Respiratory motor pattern generation depends on a rhythmogenic kernel located within the pre-Bötzinger complex (pre-BötC). In the present study, we tested
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Interaction between Kölliker-Fuse/A7 and the parafacial respiratory region on the control of respiratory regulation Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-12-01 Luiz M. Oliveira, Thiago S. Moreira, Ana C. Takakura
Respiration is regulated by various types of neurons located in the pontine-medullary regions. The Kölliker-Fuse (KF)/A7 noradrenergic neurons play a role in modulating the inspiratory cycle by influencing the respiratory output. These neurons are interconnected and may also project to brainstem and spinal cord, potentially involved in regulating the post-inspiratory phase. In the present study, we
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Reproducibility and responsiveness of airway impedance measures derived from the forced oscillation technique across different operating lung volumes Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-28 Craig R. Aitken, Girish Pathangey, Mathew Stamos, Chul-Ho Kim, Bruce D. Johnson, Glenn M. Stewart
Background The forced oscillation technique (FOT) enables non-invasive measurement of respiratory system impedance. Limited data exists on how changes in operating lung volume (OLV) impact FOT-derived measures of airway resistance (Rrs) and reactance (Xrs). Objectives This study examined the reproducibility and responsiveness of FOT-derived measures of Rrs and Xrs during simulated changes in OLV. Methods
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Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-23 Lorenzo A. Miller, Rudolf K. Braun, Regina J. Golding, Michael Lasarev, Allison C. Rodgers, Sarah El-Meanawy, Timothy A. Hacker, Marlowe W. Eldridge, Awni M. Al-Subu
Purpose To investigate the correlation between volume of carbon dioxide elimination (V̇CO2) and end-tidal carbon dioxide (PETCO2) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model. Methods Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using
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Disinhibition does not play a role in endomorphin-2-induced changes in inspiratory motoneuron output produced by in vitro neonatal rat preparations Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-07 Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Low level activation of mu-opioid receptors (MORs) in neonatal rat brainstem-spinal cord preparations increases inspiratory burst amplitude recorded on cervical spinal roots. We tested whether: (1) MOR activation with an endogenous ligand, such as endomorphin-2, increases inspiratory burst amplitude, (2) disinhibition of GABAergic or glycinergic inhibitory synaptic transmission is involved, and (3)
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Age influences the specific force and fatigability of the external abdominal obliques but not pectoralis major muscles Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-07 Matthew J. Fogarty
In the elderly, airway infections are associated with impaired airway defense behaviors, leading to an increased risk of airway infection. The muscles of the chest and abdominal wall are essential for performing effective airway defense manoeuvres, however, very little is known about their function in aging. Here in the 6- and 24-months old Fischer 344 rat model of aging, we assess the contractility
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Cardiorespiratory coupling is associated with exercise capacity in athletes: A cross-sectional study Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-11 Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Étore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Purpose To determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels in athletes and non-athletes’ subjects. Methods A cross-sectional study was carried out in 42 apparently healthy male subjects, aged between 20 and 40 years old. The participants were allocated into athletes (n = 21) and non-athletes (n = 21) groups
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Corrigendum to “The course of lung inflation alters the central pattern of tracheobronchial cough in cat – The evidence for volume feedback during cough” [Respir. Physiol. Neurobiol. 229 (2016) 43–50] Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-07 Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
Abstract not available
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In-vivo optogenetic identification and electrophysiology of glycinergic neurons in pre-Bötzinger complex of mice Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-07 Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Hülsmann
Breathing requires distinct patterns of neuronal activity in the brainstem. The most critical part of the neuronal network responsible for respiratory rhythm generation is the preBötzinger Complex (preBötC), located in the ventrolateral medulla. This area contains both rhythmogenic glutamatergic neurons and also a high number of inhibitory neurons. Here, we aimed to analyze the activity of glycinergic
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Low level CO2 supplementation maintains isocapnia and reveals ventilatory long-term facilitation in rats Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-05 Shawn Miller, Edgar Juarez Lopez, Jessica M.L. Grittner, Brendan J. Dougherty
Acute, intermittent hypoxia (AIH) induces ventilatory long-term facilitation (vLTF) in awake, freely behaving rats under poikilocapnic and isocapnic experimental conditions. Establishing pre-clinical methods for vLTF induction that more closely align with successful protocols in humans and anesthetized rats would minimize dissonance in experimental findings and improve translational aspects of vLTF
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Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C2 hemisection Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-11-01 Alyssa R. Mickle, Jesús D. Peñaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Cervical spinal cord injury creates lasting respiratory deficits which can require mechanical ventilation long-term. We have shown that closed-loop epidural stimulation (CL-ES) elicits respiratory plasticity in the form of increased phrenic network excitability (Malone et. al., E Neuro, Vol 9, 0426–21.2021, 2022); however, the ability of this treatment to create functional benefits for breathing function
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Sarcopenia of the longitudinal tongue muscles in rats Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-18 Gary C. Sieck, Genesis A. Hernandez-Vizcarrondo, Alyssa D. Brown, Matthew J. Fogarty
The tongue is a muscular hydrostat, with lingual movements occurring during breathing, chewing, swallowing, vocalization, vomiting, coughing and grooming/sexual activities. In the elderly, reduced lingual dysfunction and weakness contribute to increased risks of obstructive sleep apnea and aspiration pneumonia. In Fischer 344 (F344) rats, a validated model of aging, hypoglossal motor neuron death is
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Effects of body postures on respiratory muscle force and coughing in healthy people Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-21 Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
The respiratory muscle force determines the intensity of cough force. A greater cough force for cleaning the airways is essential for preventing and managing pneumonia. Body posture can affect the onset of aspiration pneumonia. However, the effects of body posture on the respiratory muscle and cough forces remain unclear. Thus, we aimed to explore the influence of the four body postures on respiratory
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Impact of high-intensity interval hyperpnea on aerobic energy release and inspiratory muscle fatigue Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-13 Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Respiratory muscle endurance training reportedly has beneficial effects on whole-body endurance performance. We produced a novel high-intensity interval (HII) protocol and characterized the associated physiological responses and respiratory muscle fatigue. Peak oxygen uptake of respiratory muscle (V̇O2peakRM) was estimated during the respiratory incremental test. The HII session consisted of five 3-minute
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Cough and swallow after laparotomy in anesthetized cats Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-17 Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
An anesthetized cat animal model was used to evaluate changes in cough and swallow after a small midline upper abdominal incision (laparotomy). Two additional conditions were tested: sealing the laparotomy with gentle suctioning via a small cannula, and subsequent closure of the abdominal wall with suture. These abdominal wall manipulations resulted in no changes in the cough reflex, but produced higher
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Pulmonary oxygen toxicity index during linear change in PO2: HBO treatment tables and dive planning Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-12 R. Arieli
Abstract not available
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Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-09 Amal Machfer, Sémah Tagougui, Nadia Fekih, Hayfa Ben Haj Hassen, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Hamdi Chtourou
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Insights into exercise-induced rhinitis based on nasal aerodynamics induced by airway morphology Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-07 Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Background Exercise-induced rhinitis (EIR) is a poorly understood phenomenon that may be related to increased inspiratory airflow. Characterization of the development of EIR is important to understand contributing factors. Objective To characterize how different nasal morphologies respond to airflow-related variables during rapid/deep inspiratory conditions. Methods Subject-specific nasal airways were
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Physiological responses during static apnoea efforts in elite and novice breath-hold divers before and after two weeks of dry apnoea training Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-10-04 Dimitrios I. Bourdas, Nickos D. Geladas
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Ventilatory Limitations in Patients with HFpEF and Obesity Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-26 Tony G. Babb, Bryce N. Balmain, Andrew R. Tomlinson, Linda S. Hynan, Benjamin D. Levine, James P. MacNamara, Satyam Sarma
Heart failure with preserved ejection fraction (HFpEF) patients have an increased ventilatory demand. Whether their ventilatory capacity can meet this increased demand is unknown, especially in those with obesity. Body composition (DXA) and pulmonary function were measured in 20 patients with HFpEF (69±6 yr;9 M/11 W). Cardiorespiratory responses, breathing mechanics, and ratings of perceived breathlessness
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Integrative assessment of cerebral blood regulation in COPD patients Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-26 Daniel I. Corrêa, Marcelo de-Lima-Oliveira, Ricardo C. Nogueira, Regina M. Carvalho-Pinto, Edson Bor-Seng-Shu, Ronney B. Panerai, Celso R.F. Carvalho, Angela SM. Salinet
Cerebrovascular responses were compared between COPD and non-COPD participants. The association between COPD severity and cognitive function was also investigated. Cerebral blood velocity in the middle cerebral artery, blood pressure, and end-tidal CO2 were recorded at rest, followed by a brain activation paradigm, and an inhaled gas mixture (5% CO2) to assess cerebral autoregulation (CA), neurovascular
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Examining the haemodynamic repercussions of ventilator hyperinflation in elderly patients: An explanatory study Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-20 Manuella Melo Galhardo, Sergio Luiz Soares Marcos da Cunha Chermont, Isabella Christina Diniz de Lemos Venancio, Agnaldo José Lopes, Fernando Silva Guimaraes
This study assessed the cardiovascular repercussions of two VHI (ventilation hyperinflation) protocols using the volume-controlled mode, one with an inspiratory pause (VHI-P) and the other without an inspiratory pause (VHI-NP), in mechanically ventilated elderly patients. The patients underwent both VHI protocols in a randomized order, and impedance cardiography was used to record cardiovascular variables
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KCNK3 channel is important for the ventilatory response to hypoxia in rats Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-20 Céline-Hivda Yegen, Mélanie Lambert, Antoine Beurnier, David Montani, Marc Humbert, Carole Planès, Emilie Boncoeur, Nicolas Voituron, Fabrice Antigny
To clarify the contribution of KCNK3/TASK-1 channel chemoreflex in response to hypoxia and hypercapnia, we used a unique Kcnk3-deficient rat. We assessed ventilatory variables using plethysmography in Kcnk3-deficient and wild-type rats at rest in response to hypoxia (10% O2) and hypercapnia (4% CO2). Immunostaining for C-Fos, a marker of neuronal activity, was performed to identify the regions of the
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Exercise evaluation with metabolic and ventilatory responses and blood lactate concentration in mice Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-19 Akira Yoshikawa, Makito Iizuka, Mitsuko Kanamaru, Shotaro Kamijo, Hirokazu Ohtaki, Masahiko Izumizaki
This study aimed to clarify the differential exercise capacity between 2-month-old and 10-month-old mice using an incremental running test. Metabolic and ventilatory responses and blood lactate concentration were measured to evaluate exercise capacity. We examined whether incremental running test results reflected metabolic and ventilatory responses and blood lactate concentration observed during the
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Pathophysiology of hypoxemia in mechanically-ventilated patients with COVID-19: A computed tomography study Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-11 Alessandro Santini, Alessandro Protti, Michele Ferrari, Francesca Pennati, Luca Pugliese, Cesare Mercalli, Andrea Aliverti, Maurizio Cecconi
The pathogenesis of hypoxemia during acute respiratory distress syndrome caused by SARS-CoV-2 infection (C-ARDS) is debated. Some observations led to hypothesize ventilation to perfusion mismatch, rather than anatomical shunt, as the main determinant of hypoxemia. In this observational study 24 C-ARDS patients were studied 1 (0–1) days after intubation. Patients underwent a CT scan analysis to estimate
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Lung function responses to cold water ingestion: A randomised controlled crossover trial Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-12 Louise A. Turner, Nicholas B. Tiller
This study tested the hypothesis that cold water ingestion would reduce lung function and thereby confound its measurement in a way that is mediated by both temperature and volume. In a randomised crossover trial, 10 healthy adults performed spirometry before and 5, 10, 15, and 30-minutes after consuming one-of-four drinks: 500 mL or 1000 mL refrigerated water (∼2 °C); identical water volumes at ambient
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Elevated risk of dyspnea in adults with obesity Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-09-06 Josh T. Goh, Bryce N. Balmain, Daniel P. Wilhite, Jorge Granados, Lydia L. Sandy, Yu-Lun Liu, James A. Pawelczyk, Tony G. Babb
We investigated whether older adults (OA) with obesity are more likely to have dyspnea compared with OA without obesity, and whether OA with obesity are at a greater risk of having dyspnea compared with middle-aged (MA) and younger adults (YA) with obesity. We obtained de-identified data from the TriNetX UT Southwestern Medical Center database. We identified obesity and dyspnea using ICD-10-CM codes
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Permissive hypercapnia and oxygenation impairment in premature ventilated infants Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-28 Theodore Dassios, Emma E. Williams, Ourania Kaltsogianni, Anne Greenough
Aim In permissive hypercapnia high levels of carbon dioxide (CO2) are tolerated in ventilated preterm infants to minimise lung injury, but hypercapnia could directly impair oxygenation. We aimed to quantify the association of elevated CO2 with oxygenation impairment in preterm infants by measuring the right-to-left shunt and the ventilation/perfusion (VA/Q) ratio. Methods Pre-existing datasets from
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Effects of acute resistance exercise on exhaled nitric oxide levels in non-asthmatic male Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-23 Tomoko Imai, Koichi Watanabe
Fractional nitric oxide (FeNO) is an index of eosinophilic airway inflammation. However, the effect of acute resistance exercise on FeNO is not completely known, in non-asthmatics. In this study, we aimed to assess the effects of acute resistance exercise on FeNO levels in non-asthmatics. Ten participants completed both exercise and control sessions. The resistance exercise routine consisted of three
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Increased CTGF expression in alveolar epithelial cells by cyclic mechanical stretch: Its mechanism and the therapeutic effect of pirfenidone Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-23 Junichi Aoyama, Yoshinobu Saito, Kuniko Matsuda, Toru Tanaka, Koichiro Kamio, Akihiko Gemma, Masahiro Seike
The mechanisms of fibrosis onset and development remain to be elucidated. However, it has been reported that mechanical stretch promotes fibrosis in various organs and cells, and may be involved in the pathogenesis of pulmonary fibrosis. We demonstrated that ventilator-induced lung hyperextension stimulation in mice increased the expression of connective tissue growth factor (CTGF), a profibrotic cytokine
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Regulation of vagally-evoked respiratory responses by the lateral parabrachial nucleus in the mouse Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-18 Robert Behrens, Mathias Dutschmann, Matthew Trewella, Stuart B. Mazzone, Aung Aung Kywe Moe
Vagal sensory inputs to the brainstem can alter breathing through the modulation of pontomedullary respiratory circuits. In this study, we set out to investigate the localised effects of modulating lateral parabrachial nucleus (LPB) activity on vagally-evoked changes in breathing pattern. In isoflurane-anaesthetised and instrumented mice, electrical stimulation of the vagus nerve (eVNS) produced stimulation
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Determinants of daily physical activity limitation in patients with idiopathic pulmonary fibrosis Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-12 Marcin Sikora, Dariusz Jastrzębski, Katarzyna Pilzak, Grażyna Osiadło, Dariusz Ziora, Aleksandra Żebrowska
The purpose of the study was to determine the level of physical fitness assessed based on the physiological parameters and intensity of daily physical activity (PA) of patients with idiopathic pulmonary fibrosis (IPF). Additionally, we aimed to determine the intensity and duration of exercise that would bring beneficial modifications in the cardio-respiratory system of the patients with IPF. Eighteen
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Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1–7 Respir. Physiol. Neurobiol. (IF 2.3) Pub Date : 2023-08-16 Yoshihiko Chiba, Mana Ito, Yusuke Ando, Chihiro Ueda, Michio Yamashita, Wataru Suto, Shota Ishizaka, Ai Torizuka, Chie Watanabe, Fumiko Takenoya, Motohiko Hanazaki, Hiroyasu Sakai
Objective Evidence suggest that the renin-angiotensin system (RAS) is activated in people with asthma, although its pathophysiological role is unclear. Angiotensin-converting enzyme 2 (ACE2) is the major enzyme that converts angiotensin II to angiotensin 1–7 (Ang-1–7), and is also known as a receptor of SARS-CoV-2. The current study was conducted to identify the change in RAS-related gene expression