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Neurobiological basis of emergence from anesthesia Trends Neurosci. (IF 15.9) Pub Date : 2024-03-14 Xue-Jun Song, Jiang-Jian Hu
The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective
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The selfish network: how the brain preserves behavioral function through shifts in neuronal network state Trends Neurosci. (IF 15.9) Pub Date : 2024-03-13 Albrecht Stroh, Susann Schweiger, Jan-Marino Ramirez, Oliver Tüscher
Neuronal networks possess the ability to regulate their activity states in response to disruptions. How and when neuronal networks turn from physiological into pathological states, leading to the manifestation of neuropsychiatric disorders, remains largely unknown. Here, we propose that neuronal networks intrinsically maintain network stability even at the cost of neuronal loss. Despite the new stable
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Targeting the intracellular neurexin interactome by in vivo proximity ligation Trends Neurosci. (IF 15.9) Pub Date : 2024-03-06 Ming-Han Wang, Yue Hao, Xia-Jing Tong
In a recent study, used the proximity ligation technique TurboID to scrupulously characterize the interactome of the intracellular domain (ICD) of neurexin, revealing that this domain may be involved in presynaptic actin assembly by interacting with actin-associated proteins.
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The emergence of multiscale connectomics-based approaches in stroke recovery Trends Neurosci. (IF 15.9) Pub Date : 2024-02-23 Shahrzad Latifi, S. Thomas Carmichael
Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments in brain readout technologies and progress in complex network modeling have revolutionized current understanding of the effects of stroke on brain networks at a macroscale, reorganization of smaller
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A noncoding role of coding mRNA in monogenic olfactory receptor choice Trends Neurosci. (IF 15.9) Pub Date : 2024-02-19 Yue Hao, Kang-Ying Qian, Qian Li
In a recent study, uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.
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Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias Trends Neurosci. (IF 15.9) Pub Date : 2024-02-14 Liedewei Van de Vondel, Jonathan De Winter, Vincent Timmerman, Jonathan Baets
International consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being
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Protein–protein interactions regulating α-synuclein pathology Trends Neurosci. (IF 15.9) Pub Date : 2024-02-13 Jiannan Wang, Lijun Dai, Sichun Chen, Zhaohui Zhang, Xin Fang, Zhentao Zhang
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the formation of Lewy bodies (LBs). The main proteinaceous component of LBs is aggregated α-synuclein (α-syn). However, the mechanisms underlying α-syn aggregation are not yet fully understood. Converging lines of evidence indicate that,
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Contiguity in perception: origins in cellular associative computations Trends Neurosci. (IF 15.9) Pub Date : 2024-02-02 C, h, r, i, s, t, i, a, n, , H, a, n, s, e, l
Our brains are good at detecting and learning associative structures; according to some linguistic theories, this capacity even constitutes a prerequisite for the development of syntax and compositionality in language and verbalized thought. I will argue that the search for associative motifs in input patterns is an evolutionary old brain function that enables contiguity in sensory perception and orientation
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Tuning neural circuits and behaviors by microglia in the adult brain Trends Neurosci. (IF 15.9) Pub Date : 2024-01-19 Shunyi Zhao, Anthony D. Umpierre, Long-Jun Wu
Microglia are the primary immune cells of the CNS, contributing to both inflammatory damage and tissue repair in neurological disorder. In addition, emerging evidence highlights the role of homeostatic microglia in regulating neuronal activity, interacting with synapses, tuning neural circuits, and modulating behaviors. Herein, we review how microglia sense and regulate neuronal activity through synaptic
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Subscription and Copyright Information Trends Neurosci. (IF 15.9) Pub Date : 2024-01-09
Abstract not available
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An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions Trends Neurosci. (IF 15.9) Pub Date : 2024-01-13 Vern Lewis, Gareth Rurak, Natalina Salmaso, Argel Aguilar-Valles
Over the past six decades, the use of ketamine has evolved from an anesthetic and recreational drug to the first non-monoaminergic antidepressant approved for treatment-resistant major depressive disorder (MDD). Subanesthetic doses of ketamine and its enantiomer (S)-ketamine (esketamine) directly bind to several neurotransmitter receptors [including N-methyl-d-aspartic acid receptor (NMDAR), κ and
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Latent-state and model-based learning in PTSD Trends Neurosci. (IF 15.9) Pub Date : 2024-01-11 Josh M. Cisler, Joseph E. Dunsmoor, Gregory A. Fonzo, Charles B. Nemeroff
Post-traumatic stress disorder (PTSD) is characterized by altered emotional and behavioral responding following a traumatic event. In this article, we review the concepts of latent-state and model-based learning (i.e., learning and inferring abstract task representations) and discuss their relevance for clinical and neuroscience models of PTSD. Recent data demonstrate evidence for brain and behavioral
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The pulvinar as a hub of visual processing and cortical integration Trends Neurosci. (IF 15.9) Pub Date : 2023-12-24 Nelson Cortes, Hugo J. Ladret, Reza Abbas-Farishta, Christian Casanova
The pulvinar nucleus of the thalamus is a crucial component of the visual system and plays significant roles in sensory processing and cognitive integration. The pulvinar’s extensive connectivity with cortical regions allows for bidirectional communication, contributing to the integration of sensory information across the visual hierarchy. Recent findings underscore the pulvinar’s involvement in attentional
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Toward individualized connectomes of brain morphology Trends Neurosci. (IF 15.9) Pub Date : 2023-12-22 Jinhui Wang, Yong He
The morphological brain connectome (MBC) delineates the coordinated patterns of local morphological features (such as cortical thickness) across brain regions. While classically constructed using population-based approaches, there is a growing trend toward individualized modeling. Currently, the methods for individualized MBCs are varied, posing challenges for method selection and cross-study comparisons
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Complement-mediated synapse loss in Alzheimer’s disease: mechanisms and involvement of risk factors Trends Neurosci. (IF 15.9) Pub Date : 2023-12-20 Lang Wen, Danlei Bi, Yong Shen
The complement system is increasingly recognized as a key player in the synapse loss and cognitive impairments observed in Alzheimer’s disease (AD). In particular, the process of complement-dependent synaptic pruning through phagocytosis is over-activated in AD brains, driving detrimental excessive synapse elimination and contributing to synapse loss, which is the strongest neurobiological correlate
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Adrenergic signaling dampens T cell activity during chronic infection and cancer Trends Neurosci. (IF 15.9) Pub Date : 2023-12-20 M, a, u, r, e, e, n, , A, ., , C, o, x
Stress contributes to infection and cancer susceptibility, but the mediating mechanisms are still being elucidated. CD8 T cells are critical players in antiviral and antitumor immune responses. A recent study by together with a growing body of literature, link norepinephrine produced during the stress response to CD8 T cell dysfunction.
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The locus coeruleus as a global model failure system Trends Neurosci. (IF 15.9) Pub Date : 2023-12-14 Rebecca Jordan
Predictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and are thought to be instructive signals that drive corrective plasticity. Recent findings support the idea that the locus coeruleus (LC) – a brain-wide neuromodulatory system – signals several types of prediction error. I discuss how these
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Toward identifying key mechanisms of progression in multiple sclerosis Trends Neurosci. (IF 15.9) Pub Date : 2023-12-14 Leila Husseini, Anastasia Geladaris, Martin S. Weber
A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the accumulation of disability over an often decades-long disease course. Disability progression can result from acute relapses as well as from CNS intrinsic parenchymal disintegration without de novo CNS lesion formation. Research focus has shifted to progression not associated with acute inflammation, as it is not
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Shared gustatory sensor for acids and ammonium Trends Neurosci. (IF 15.9) Pub Date : 2023-12-09 A, k, i, y, u, k, i, , T, a, r, u, n, o
In a recent study, demonstrated that the H-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.
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Ontogeny of the circadian system: a multiscale process throughout development Trends Neurosci. (IF 15.9) Pub Date : 2023-12-08 Maria Comas, Davide De Pietri Tonelli, Luca Berdondini, Mariana Astiz
The 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about
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White matter injury across neurodegenerative disease Trends Neurosci. (IF 15.9) Pub Date : 2023-12-04 Lindsay K. Festa, Judith B. Grinspan, Kelly L. Jordan-Sciutto
Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system (CNS), are active players in shaping neuronal circuitry and function. It has become increasingly apparent that injury to cells within the OL lineage plays a central role in neurodegeneration. In this review, we focus primarily on three degenerative disorders in which white matter loss is well documented: Alzheimer’s disease
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Eye movements in Parkinson’s disease: from neurophysiological mechanisms to diagnostic tools Trends Neurosci. (IF 15.9) Pub Date : 2023-12-02 Chrystalina A. Antoniades, Miriam Spering
Movement disorders such as Parkinson’s disease (PD) impact oculomotor function – the ability to move the eyes accurately and purposefully to serve a multitude of sensory, cognitive, and secondary motor tasks. Decades of neurophysiological research in monkeys and behavioral studies in humans have characterized the neural basis of healthy oculomotor control. This review links eye movement abnormalities
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UndERACting ion channels in neurodegeneration Trends Neurosci. (IF 15.9) Pub Date : 2023-11-29 Matisse T. Jacobs, Rebecca San Gil, Adam K. Walker
In a recent study, Guo and colleagues characterised the function of an elusive endoplasmic reticulum (ER) anion channel protein, Chloride Channel CLiC Like 1 (CLCC1), and identified rare CLCC1 variants in people with amyotrophic lateral sclerosis (ALS). CLCC1 mutants disrupted ER function in vitro and promoted ALS-like pathology and neurodegeneration in mice. This work reveals a previously uncharacterised
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Identifying vagal sensory neurons driving the Bezold-Jarisch reflex Trends Neurosci. (IF 15.9) Pub Date : 2023-11-29 Beth A. Habecker
Homeostatic reflexes are crucial for life, but the subpopulations of sensory neurons that stimulate these reflexes are largely unknown. A recent paper from Lovelace, Ma, and colleagues identified a population of sensory neurons in the cardiac ventricle that underlies the Bezold-Jarisch reflex and triggers syncope (fainting).
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Subscription and Copyright Information Trends Neurosci. (IF 15.9) Pub Date : 2023-11-21
Abstract not available
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Hidden variables in stress neurobiology research Trends Neurosci. (IF 15.9) Pub Date : 2023-11-18 Ashley L. Holloway, Talia N. Lerner
Among the central goals of stress neurobiology research is to understand the mechanisms by which stressors change neural circuit function to precipitate or exacerbate psychiatric symptoms. Yet despite decades of effort, psychiatric medications that target the biological substrates of the stress response are largely lacking. We propose that the clinical advancement of stress response-based therapeutics
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Epigenetic mechanisms underlying sex differences in the brain and behavior Trends Neurosci. (IF 15.9) Pub Date : 2023-11-15 Marija Kundakovic, Maria Tickerhoof
Sex differences are found across brain regions, behaviors, and brain diseases. Sexual differentiation of the brain is initiated prenatally but it continues throughout life, as a result of the interaction of three major factors: gonadal hormones, sex chromosomes, and the environment. These factors are thought to act, in part, via epigenetic mechanisms which control chromatin and transcriptional states
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Capturing postpandemic changes in research participants Trends Neurosci. (IF 15.9) Pub Date : 2023-11-10 Marian E. Berryhill
The impact of the COVID-19 pandemic on physical and mental health hardly need be reiterated. Yet, there are likely other indirect aftereffects of COVID-19 infection in addition to the direct effects. This article aims to initiate a conversation regarding difficult-to-capture outcomes of the pandemic that are relevant to researchers who test human participants. These considerations encourage collection
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Curiosity-driven exploration: foundations in neuroscience and computational modeling Trends Neurosci. (IF 15.9) Pub Date : 2023-11-02 Alireza Modirshanechi, Kacper Kondrakiewicz, Wulfram Gerstner, Sebastian Haesler
Curiosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and
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Mapping brain circuits for murine maternal behavior triggered by pup calls Trends Neurosci. (IF 15.9) Pub Date : 2023-10-31 Xinqi Lu, Rongfeng K. Hu
How sensory cues are integrated at the level of neural circuits to drive maternal behaviors remains incompletely understood. In a recent study, Valtcheva, Issa, and colleagues identified a previously unknown role for the posterior intralaminar (PIL) nucleus of the thalamus within the neural networks that mediate maternal behavior in mice induced by pup calls.
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Pallidal circuits drive addiction behavior Trends Neurosci. (IF 15.9) Pub Date : 2023-10-26 Rianne R. Campbell, Mary Kay Lobo
Understanding the neural mechanisms that control addiction processes, including drug-seeking and relapse, is key to finding new targets for substance use disorder (SUD) pharmacotherapies and circuit-based therapies. Addictive drugs alter activity in distinct neural circuits that can lead to SUD symptoms, including compulsive drug craving and taking. This includes the pallidum, a region in the basal
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Subscription and Copyright Information Trends Neurosci. (IF 15.9) Pub Date : 2023-10-17
Abstract not available
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The feasibility of artificial consciousness through the lens of neuroscience Trends Neurosci. (IF 15.9) Pub Date : 2023-10-18 Jaan Aru, Matthew E. Larkum, James M. Shine
Interactions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms
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Targeting LRRK2 mRNA stability in Parkinson’s disease Trends Neurosci. (IF 15.9) Pub Date : 2023-10-18 Rachel Fasiczka, Sabine Hilfiker
In a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson’s disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson’s disease
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The making of a proprioceptor: a tale of two identities Trends Neurosci. (IF 15.9) Pub Date : 2023-10-17 Joriene C. de Nooij, Niccolò Zampieri
Proprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect
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Lysosomes in retinal health and disease Trends Neurosci. (IF 15.9) Pub Date : 2023-10-16 Patricia Boya, Kai Kaarniranta, James T. Handa, Debasish Sinha
Lysosomes play crucial roles in various cellular processes – including endocytosis, phagocytosis, and autophagy – which are vital for maintaining retinal health. Moreover, these organelles serve as environmental sensors and act as central hubs for multiple signaling pathways. Through communication with other cellular components, such as mitochondria, lysosomes orchestrate the cytoprotective response
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The endolysosomal pathway and ALS/FTD Trends Neurosci. (IF 15.9) Pub Date : 2023-10-10 Tiffany W. Todd, Wei Shao, Yong-jie Zhang, Leonard Petrucelli
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be part of a disease spectrum that is associated with causative mutations and risk variants in a wide range of genes. Mounting evidence indicates that several of these genes are linked to the endolysosomal system, highlighting the importance of this pathway in ALS/FTD. Although many studies have focused on how disruption
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Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS Trends Neurosci. (IF 15.9) Pub Date : 2023-10-06 Rachael Dangarembizi, Rebecca Drummond
Cryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible
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Disrupted circadian rhythms in the plateau pika Trends Neurosci. (IF 15.9) Pub Date : 2023-10-04 Ziqing Yu, Eric Erquan Zhang
The plateau pika (Ochotona curzoniae) is the most populous mammal on the ‘third pole’, the Qinghai–Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme
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Visual attention and processing in jumping spiders Trends Neurosci. (IF 15.9) Pub Date : 2023-10-03 Alex M. Winsor, Luke Remage-Healey, Ronald R. Hoy, Elizabeth M. Jakob
Jumping spiders have extraordinary vision. Using multiple, specialized eyes, these spiders selectively gather and integrate disparate streams of information about motion, color, and spatial detail. The saccadic movements of a forward-facing pair of eyes allow spiders to inspect their surroundings and identify objects. Here, we discuss the jumping spider visual system and how visual information is attended
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A thalamocortical pathway controlling impulsive behavior Trends Neurosci. (IF 15.9) Pub Date : 2023-09-30 Robertas Guzulaitis, Lucy M. Palmer
Planning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal
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Air pollution, glymphatic impairment, and Alzheimer's disease Trends Neurosci. (IF 15.9) Pub Date : 2023-09-28 Rashad Hussain, Uschi Graham, Alison Elder, Maiken Nedergaard
Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the
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Subscription and Copyright Information Trends Neurosci. (IF 15.9) Pub Date : 2023-09-19
Abstract not available
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Internal models of self-motion: neural computations by the vestibular cerebellum Trends Neurosci. (IF 15.9) Pub Date : 2023-09-20 Kathleen E. Cullen
The vestibular cerebellum plays an essential role in maintaining our balance and ensuring perceptual stability during activities of daily living. Here I examine three key regions of the vestibular cerebellum: the floccular lobe, anterior vermis (lobules I–V), and nodulus and ventral uvula (lobules X–IX of the posterior vermis). These cerebellar regions encode vestibular information and combine it with
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Neurobiological tradeoffs of headbutting bovids Trends Neurosci. (IF 15.9) Pub Date : 2023-09-19 Nicole L. Ackermans
Bovids are notorious for their high-force headbutting fights for herd dominance. Here, I discuss the evolutionary tradeoff between headbutting and brain damage incurred by bovids’ reproductive strategy. The specific behavioral and neuroanatomical adaptations of these animals are placed in context of the neuropathology of repetitive brain trauma.
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PET reporter systems for the brain Trends Neurosci. (IF 15.9) Pub Date : 2023-09-19 Sridhar Goud Nerella, Michael Michaelides, Takafumi Minamimoto, Robert B. Innis, Victor W. Pike, Mark A.G. Eldridge
Positron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer
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Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity Trends Neurosci. (IF 15.9) Pub Date : 2023-09-16 Lynde M. Wangler, Jonathan P. Godbout
Most of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity
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The role of the hippocampus in the consolidation of emotional memories during sleep Trends Neurosci. (IF 15.9) Pub Date : 2023-09-14 Éléonore Pronier, Juan Facundo Morici, Gabrielle Girardeau
Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for contextual memory, while the ventral hippocampus (vHPC) is more involved in emotional processing. Here, we review the literature in rodents highlighting the anatomical and functional properties of the hippocampus along its dorsoventral
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Synaptic crossroads: navigating the circuits of movement Trends Neurosci. (IF 15.9) Pub Date : 2023-09-08 Eduardo Maristany de las Casas, Naoya Takahashi
The anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.
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The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans Trends Neurosci. (IF 15.9) Pub Date : 2023-09-06 Lisa Bauer, Feline F.W. Benavides, Edwin J.B. Veldhuis Kroeze, Emmie de Wit, Debby van Riel
Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI
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Synapse organizers as molecular codes for synaptic plasticity Trends Neurosci. (IF 15.9) Pub Date : 2023-08-29 Steven A. Connor, Tabrez J. Siddiqui
Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at the level of individual synapses. Their importance is demonstrated by the major brain disorders that emerge when their function is compromised. The mechanisms whereby the various families of organizers govern synapses are diverse, but converge on the structure, function
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Cold blooded vertebrates help unveil a heat-dependent trigger Trends Neurosci. (IF 15.9) Pub Date : 2023-08-29 Sebastian E. Brauchi
In a recent study, Hori and colleagues demonstrated that two specific residues located in the first ankyrin repeat of TRPV1 channels modulate the threshold for temperature activation. This study highlights the importance of considering natural diversity and comparative biology when approaching biophysical questions.
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A critical period plasticity framework for the sensorimotor–association axis of cortical neurodevelopment Trends Neurosci. (IF 15.9) Pub Date : 2023-08-28 Bart Larsen, Valerie J. Sydnor, Arielle S. Keller, B.T. Thomas Yeo, Theodore D. Satterthwaite
To understand human brain development it is necessary to describe not only the spatiotemporal patterns of neurodevelopment but also the neurobiological mechanisms that underlie them. Human neuroimaging studies have provided evidence for a hierarchical sensorimotor-to-association (S–A) axis of cortical neurodevelopment. Understanding the biological mechanisms that underlie this program of development
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Inflammasome assembly in neurodegenerative diseases Trends Neurosci. (IF 15.9) Pub Date : 2023-08-24 Jagjit Singh, Maria L. Habean, Nikhil Panicker
Neurodegenerative disorders are characterized by the progressive dysfunction and death of selectively vulnerable neuronal populations, often associated with the accumulation of aggregated host proteins. Sustained brain inflammation and hyperactivation of inflammasome complexes have been increasingly demonstrated to contribute to neurodegenerative disease progression. Here, we review molecular mechanisms