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The effects of the Unified Protocol and Unified Protocol skills on loneliness in the COVID-19 pandemic Depression Anxiety (IF 7.4) Pub Date : 2022-11-13 Matthew W. Southward, Douglas R. Terrill, Shannon Sauer-Zavala
Loneliness is a significant public health concern with no established first-line intervention although modular, transdiagnostic, cognitive-behavioral interventions, such as the Unified Protocol (UP), are promising candidates. The UP contains skill modules to target anxiety, depression, and related conditions, although it is unclear if the UP can reduce loneliness and if UP skill use contributes to
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Dynamics of daily positive and negative affect and relations to anxiety and depression symptoms in a transdiagnostic clinical sample Depression Anxiety (IF 7.4) Pub Date : 2022-11-13 Joyce Y. Zhu, André Plamondon, Abby L. Goldstein, Ivar Snorrason, Jasmin Katz, Thröstur Björgvinsson
Despite interest in transdiagnostic dimensional approaches to psychopathology, little is known about the dynamic interplay of affecting and internalizing symptoms that cut across diverse mental health disorders. We examined within-person reciprocal effects of negative and positive affect (NA, PA) and symptoms (depression and anxiety), and their between-person associations with affective dynamics (i
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Sex-based variations of prefrontal structure and longitudinal symptoms in pediatric posttraumatic stress disorder Depression Anxiety (IF 7.4) Pub Date : 2022-11-09 Sara A. Heyn, Sophie Bailowitz, Justin D. Russell, Ryan J. Herringa
Background: Pediatric posttraumatic stress disorder (pPTSD) is more than three times as likely to develop in trauma-exposed female youth than males. Despite the staggering sex differences in the prevalence rates of pPTSD and symptom expression, relatively little is known about the underlying biomarkers of these sex-based variations in pPTSD as compared to typically development. Methods: The Youth PTSD
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Within-day bidirectional associations between physical activity and affect: A real-time ambulatory study in persons with and without depressive and anxiety disorders Depression Anxiety (IF 7.4) Pub Date : 2022-11-07 Sonia Difrancesco, Brenda W. J. H. Penninx, Kathleen R. Merikangas, Albert M. van Hemert, Harriëtte Riese, Femke Lamers
Ambulatory assessments offer opportunities to study physical activity level (PAL) and affect at the group and person-level. We examined bidirectional associations between PAL and affect in a 3-h timeframe and evaluated whether associations differ between people with and without current or remitted depression/anxiety.
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Elucidating behavioral and functional connectivity markers of aberrant threat discrimination in PTSD Depression Anxiety (IF 7.4) Pub Date : 2022-11-06 John R. Keefe, Benjamin Suarez-Jimenez, Xi Zhu, Amit Lazarov, Ariel Durosky, Sara Such, Caroline Marohasy, Shmuel Lissek, Yuval Neria
Patients with posttraumatic stress disorder (PTSD) tend to overgeneralize threat to safe stimuli, potentially reflecting aberrant stimuli discrimination. Yet, it is not clear whether threat overgeneralization reflects general discrimination deficits, or rather a specific bias related to aversive stimuli. Here we tested this question and characterized the neural correlates of threat discrimination.
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Decision-making biases in suicide attempters with major depressive disorder: A computational modeling study using the balloon analog risk task (BART) Depression Anxiety (IF 7.4) Pub Date : 2022-11-03 Qinyu Liu, Runqing Zhong, Xinlei Ji, Samuel Law, Fan Xiao, Yiming Wei, Shulin Fang, Xinyuan Kong, Xiaocui Zhang, Shuqiao Yao, Xiang Wang
In the last decade, suicidality has been increasingly theorized as a distinct phenomenon from major depressive disorder (MDD), with unique psychological and neural mechanisms, rather than being mostly a severe symptom of MDD. Although decision-making biases have been widely reported in suicide attempters with MDD, little is known regarding what components of these biases can be distinguished from depressiveness
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Individualized prediction of consummatory anhedonia from functional connectome in major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-11-03 Fengqiong Yu, Huihua Fang, Junfeng Zhang, Zhihao Wang, Hui Ai, Veronica P. Y. Kwok, Ya Fang, Yaru Guo, Xin Wang, Chunyan Zhu, Yuejia Luo, Pengfei Xu, Kai Wang
Anhedonia is a key symptom of major depressive disorder (MDD) and other psychiatric diseases. The neural basis of anhedonia has been widely examined, yet the interindividual variability in neuroimaging biomarkers underlying individual-specific symptom severity is not well understood.
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Real-time assessment of positive and negative affective fluctuations and mood lability in a transdiagnostic sample of youth Depression Anxiety (IF 7.4) Pub Date : 2022-11-03 Reut Naim, Shannon Shaughnessy, Ashley Smith, Sarah L. Karalunas, Katharina Kircanski, Melissa A. Brotman
Emotional lability, defined as rapid and/or intense affect fluctuations, is associated with pediatric psychopathology. Although numerous studies have examined labile mood in clinical groups, few studies have used real-time assessments in a well-characterized transdiagnostic sample, and no prior study has included participants with disruptive mood dysregulation disorder (DMDD). The present study leverages
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White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions Depression Anxiety (IF 7.4) Pub Date : 2022-11-02 Deanna M. Barch, Xiao Hua, Sridhar Kandala, Michael P. Harms, Ashley Sanders, Rebecca Brady, Rebecca Tillman, Joan L. Luby
Introduction: Compared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal
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Prospective associations of text-message-based sentiment with symptoms of depression, generalized anxiety, and social anxiety Depression Anxiety (IF 7.4) Pub Date : 2022-10-25 Caitlin A. Stamatis, Jonah Meyerhoff, Tingting Liu, Garrick Sherman, Harry Wang, Tony Liu, Brenda Curtis, Lyle H. Ungar, David C. Mohr
Language patterns may elucidate mechanisms of mental health conditions. To inform underlying theory and risk models, we evaluated prospective associations between in vivo text messaging language and differential symptoms of depression, generalized anxiety, and social anxiety.
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Psychiatric morbidity among men using anabolic steroids Depression Anxiety (IF 7.4) Pub Date : 2022-10-25 Josefine Windfeld-Mathiasen, Thea Christoffersen, Niels August Willer Strand, Kim Dalhoff, Jon Trærup Andersen, Henrik Horwitz
The purpose of this study was to investigate the psychiatric morbidity among men with abuse of anabolic steroids.
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PTSD, major depression, and advanced transcriptomic age in brain tissue Depression Anxiety (IF 7.4) Pub Date : 2022-10-25 Xiang Zhao, Mark W. Logue, Sage E. Hawn, Zoe E. Neale, Zhenwei Zhou, Bertrand R. Huber, , Mark W. Miller, Erika J. Wolf
Psychiatric disorders have been associated with advanced epigenetic age in DNA methylation, yet this relationship has not been studied in the brain transcriptome. We examined transcriptomic age using an RNA-based algorithm recently developed by Ren and Kuan (“RNAAgeCalc”) and the associations between posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and alcohol use disorder with
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A pilot randomized effectiveness trial of the unified protocol in trauma-exposed veterans Depression Anxiety (IF 7.4) Pub Date : 2022-10-18 Cassidy A. Gutner, Jiyoung Song, Caroline A. Canale, Michael K. Suvak, Scott D. Litwack, Barbara L. Niles, Shannon Wiltsey Stirman
The unified protocol (UP) is a promising transdisgnostic treatment for emotional disorders; limited data exists with trauma-exposed populations. This study compared effectiveness of the UP, presented centered therapy (PCT), and treatment as usual (TAU) in trauma-exposed veterans presenting to routine care.
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The relationship between physical activity states and depressive symptoms: Using ambulatory assessment to characterize day-to-day associations among individuals with and without bipolar spectrum disorder Depression Anxiety (IF 7.4) Pub Date : 2022-10-18 Rachel F. L. Walsh, Logan T. Smith, Madison K. Titone, Tommy H. Ng, Namni Goel, Lauren B. Alloy
The role of activation in the pathogenesis of bipolar spectrum disorders (BSD) is of growing interest. Physical activity is known to improve mood, but it is unclear whether low activity levels contribute to inter-episode depressive symptoms observed in BSD. This study examined whether sedentary and vigorous activity, as well as the timing of the activity, were differentially associated with next-day
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Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study Depression Anxiety (IF 7.4) Pub Date : 2022-10-11 Jeffrey R. Strawn, Yingying Xu, Kim M. Cecil, Jane Khoury, Mekibib Altaye, Joseph M. Braun, Bruce P. Lanphear, Andreas Sjodin, Aimin Chen, Kimberly Yolton
Anxiety disorders emerge during childhood and adolescence and are frequently preceded by subsyndromal anxiety symptoms. Environmental toxicants, including gestational polybrominated diphenyl ether (PBDE) exposure, are associated with neuropsychiatric sequelae; however, the role of PBDEs as risk factors for anxiety in adolescence is unclear.
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One-year incidence, predictors, and accuracy of prediction of suicidal thoughts and behaviors from the first to second year of university Depression Anxiety (IF 7.4) Pub Date : 2022-08-18 Corina Benjet, Guilherme Borges, Sumaiya Miah, Yesica Albor, Raúl A. Gutiérrez-García, Alicia Zavala Berbena, Rebeca Guzmán, Eunice Vargas-Contreras, Alicia Edith Hermosillo de la Torre, Praxedis Cristina Hernández Uribe, Guillermo Quevedo, Anabell Covarrubias Díaz, Sinead Martínez Ruiz, Karla Patricia Valdés-García, Ana María Martínez Jerez, Philippe Mortier
Research is scarce on the prospective predictors of first onset suicidal thoughts and behaviors (STB) and the accuracy of these predictors in university students, particularly in low-and-middle income countries. Therefore, we assessed the 1-year incidence of STB among first-year students, a broad range of prospective predictors of STB incidence, and evaluated the prediction accuracy of a baseline multivariate
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100,000 lumens to treat seasonal affective disorder: A proof of concept RCT of Bright, whole-ROom, All-Day (BROAD) light therapy Depression Anxiety (IF 7.4) Pub Date : 2022-08-18 Julia F. Sandkühler, Sarah Brochhagen, Paul Rohde, Rosa C. Muscheidt, Teja W. Grömer, Helge Müller, Jan M. Brauner
Seasonal affective disorder (SAD) is common and debilitating. The standard of care includes light therapy provided by a light box; however, this treatment is restrictive and only moderately effective. Advances in LED technology enable lighting solutions that emit vastly more light than traditional light boxes. Here, we assess the feasibility of BROAD (Bright, whole-ROom, All-Day) light therapy and
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Risk of major malformations in infants after first-trimester exposure to benzodiazepines: Results from the Massachusetts General Hospital National Pregnancy Registry for Psychiatric Medications Depression Anxiety (IF 7.4) Pub Date : 2022-07-31 Mercedes J. Szpunar, Marlene P. Freeman, Lauren A. Kobylski, Phoebe S. Caplin, Peter Gaccione, Adele C. Viguera, David Chitayat, Sonia Hernández-Díaz, Lee S. Cohen
Perinatal anxiety affects 20% of women, and untreated maternal mental illness can cause deleterious effects for women and their children. Benzodiazepines are commonly used to treat anxiety disorders. The reported risk of congenital malformations after in utero benzodiazepine exposure has been inconsistent.
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Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample Depression Anxiety (IF 7.4) Pub Date : 2022-07-18 Maria Granros, Annmarie MacNamara, Heide Klumpp, K. Luan Phan, Katie L. Burkhouse
Internalizing psychopathologies (IPs) are highly comorbid and exhibit substantial overlap, such as aberrant affective reactivity. Neural reactivity to emotional images, measured via the late positive potential (LPP) event-related potential (ERP) component, has been utilized to index affective reactivity in IPs. The LPP is often examined in isolation with a specific disorder, ignoring overlap between
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Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood Depression Anxiety (IF 7.4) Pub Date : 2022-07-14 Andrea D. Spadoni, Meghan Vinograd, Bruna Cuccurazzu, Katy Torres, Laura M. Glynn, Elysia P. Davis, Tallie Z. Baram, Dewleen G. Baker, Caroline M. Nievergelt, Victoria B. Risbrough
Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the
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Association between depression and epigenetic age acceleration: A co-twin control study Depression Anxiety (IF 7.4) Pub Date : 2022-06-27 Chang Liu, Zeyuan Wang, Qin Hui, Jack Goldberg, Nicholas L. Smith, Amit J. Shah, Nancy Murrah, Lucy Shallenberger, Emily Diggers, James Douglas Bremner, Yan V. Sun, Viola Vaccarino
Prior studies have shown inconsistent findings of an association between depression and epigenetic aging. DNA methylation (DNAm) age acceleration can measure biological aging. We adopted a robust co-twin control study design to examine whether depression is associated with DNAm age acceleration after accounting for the potential confounding influences of genetics and family environment.
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The effect of war injury and combat deployment on military wives’ mental health symptoms Depression Anxiety (IF 7.4) Pub Date : 2022-06-16 Stephen J. Cozza, Christin M. Ogle, Joscelyn E. Fisher, Jing Zhou, Rafael F. Zuleta, Carol S. Fullerton, Robert J. Ursano
Although much has been learned about the physical and psychological impacts of deployment and combat injury on military service members, less is known about the effects of these experiences on military spouses.
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Structural brain features signaling trauma, PTSD, or resilience? A systematic exploration Depression Anxiety (IF 7.4) Pub Date : 2022-06-16 Sigal Zilcha-Mano, Xi Zhu, Amit Lazarov, Benjamin Suarez-Jimenez, Liat Helpman, Yoojean Kim, Carly Maitlin, Yuval Neria, Bret R. Rutherford
Studies have searched for neurobiological markers of trauma exposure, posttraumatic stress disorder (PTSD) diagnosis, and resilience to trauma to identify therapeutic targets for PTSD. Despite some promising results, findings are inconsistent.
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Targeting cognitive control to reduce anxiety in very young children: A proof of concept study Depression Anxiety (IF 7.4) Pub Date : 2022-06-16 Hans S. Schroder, Ka I. Ip, Jessica L. Hruschak, Faith Horbatch, Melissa Hall, Yanni Liu, Kristin Mannella, Maria Muzik, Kate L. Rosenblum, Jason S. Moser, Kate D. Fitzgerald
Underdeveloped cognitive control (CC)—the capacity to flexibly adjust to changing environments—may predispose some children to early onset anxiety disorders and represents a promising intervention target. The current study established and pilot-tested “Camp Kidpower”—a novel group-based, interactive CC training intervention—and assessed its impacts on behavioral and neurophysiological indices of CC
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Involvement of the brain–heart axis in the link between PTSD and cardiovascular disease Depression Anxiety (IF 7.4) Pub Date : 2022-06-16 Antonia V. Seligowski, Theresa K. Webber, Paul J. Marvar, Kerry J. Ressler, Noah S. Philip
Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number of mechanisms have been implicated to underlie this brain–heart axis relationship, such as altered functioning of the autonomic nervous system and increased systemic inflammation. While neural alterations have repeatedly been observed in PTSD, they are rarely considered in
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Altered motivation of effortful decision-making for self and others in subthreshold depression Depression Anxiety (IF 7.4) Pub Date : 2022-06-03 Rong Bi, Wanxin Dong, Zixin Zheng, Sijin Li, Dandan Zhang
Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear.
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"Editorial leadership change for Depression and Anxiety". Depression Anxiety (IF 7.4) Pub Date : 2022-06-01 Murray B Stein Md Mph Frcpc
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Trauma-focused guided self-help interventions for posttraumatic stress disorder: A meta-analysis of randomized controlled trials Depression Anxiety (IF 7.4) Pub Date : 2022-05-27 Andy P. Siddaway, Richard Meiser-Stedman, Verity Chester, Jack Finn, Cliodhna O. Leary, David Peck, Camilla Loveridge
Trauma-focused guided self-help (TF-GSH) is an important alternative to psychological therapy delivered by a therapist. This meta-analysis evaluates the efficacy of TF-GSH in reducing posttraumatic stress disorder (PTSD) symptoms and comorbid depressive and anxiety symptoms. A total of 17 trials were included that compared a TF-GSH intervention (N = 610) to various control comparators (N = 570). Control
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Depressive and anxious symptoms among young adults in the COVID-19 pandemic: Results from monitoring the future Depression Anxiety (IF 7.4) Pub Date : 2022-05-27 Noah T. Kreski, Katherine M. Keyes, Michael J. Parks, Megan E. Patrick
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is associated with worsening mental health among young adults, but further research is necessary to quantify the associations with depression and anxiety.
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Neural markers of emotion regulation difficulties moderate effects of COVID-19 stressors on adolescent depression Depression Anxiety (IF 7.4) Pub Date : 2022-05-23 Resh S. Gupta, Lindsay Dickey, Autumn Kujawa
Stressful events, such as those imposed by the COVID-19 pandemic, are associated with depression risk, raising questions about processes that make some people more susceptible to the effects of stress on mental health than others. Emotion regulation may be a key process, but methods for objectively measuring emotion regulation abilities in youth are limited. We leveraged event-related potential (ERP)
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Association of adversity with psychopathology in early childhood: Dimensional and cumulative approaches Depression Anxiety (IF 7.4) Pub Date : 2022-05-20 Cheryl R. Stein, Margaret A. Sheridan, William E. Copeland, Laura S. Machlin, Kimberly L. H. Carpenter, Helen L. Egger
The association between adversity and psychopathology in adolescents and adults is characterized by equifinality. These associations, however, have not been assessed during early childhood when psychopathology first emerges. Defining adversity using both dimensional and cumulative risk approaches, we examined whether specific types of adversity are differentially associated with psychopathology in
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The effects of varenicline, bupropion, nicotine patch, and placebo on smoking cessation among smokers with major depression: A randomized clinical trial Depression Anxiety (IF 7.4) Pub Date : 2022-05-09 Paul M. Cinciripini, George Kypriotakis, Charles Green, David Lawrence, Robert M. Anthenelli, Jennifer Minnix, Janice A. Blalock, Diane Beneventi, Chad Morris, Maher Karam-Hage
Improving treatment outcomes for smokers with major depressive disorder (MDD) can have significant public health implications.
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Longitudinal relationship between sensory impairments and depressive symptoms in older adults: The mediating role of functional limitation Depression Anxiety (IF 7.4) Pub Date : 2022-05-11 Shimin Zhang, Qiong Wang, Xiyuan Wang, Kaili Qi, Yanxin Zhou, Chengchao Zhou
The underlying mechanism between sensory impairments (SIs) and depressive symptoms among Chinese older adults is not well understood. This study aims to explore the mediating role of functional limitation on the longitudinal relationship between SIs and depressive symptoms among older adults in China.
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How does social support modify the association between psychological distress and risk of suicide death? Depression Anxiety (IF 7.4) Pub Date : 2022-05-11 Tatsui Otsuka, Yumi Sugawara, Sanae Matsuyama, Ichiro Tsuji
Social support (SS) has been reported as a factor preventing suicide death, but whether this association is independent of mental status is unclear. The present study examined the effect modification of SS on the association between psychological distress status and risk of suicide death.
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COVID-19-related posttraumatic stress disorder in adults with lived experience of psychiatric disorder Depression Anxiety (IF 7.4) Pub Date : 2022-05-10 Catrin Lewis, Katie Lewis, Alice Roberts, Claudia Evison, Bethan Edwards, Ann John, Keith Lloyd, Holly Pearce, Rob Poole, Natalie Richards, Catherine Robinson, Ian Jones, Jonathan I. Bisson
Prevalence estimates of COVID-19-related posttraumatic stress disorder (PTSD) have ranged from 1% to over 60% in the general population. Individuals with lived experience of a psychiatric disorder may be particularly vulnerable to COVID-19-related PTSD but this has received inadequate attention.
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Neural correlates of anxious distress in depression: A neuroimaging study of reactivity to emotional faces and resting-state functional connectivity Depression Anxiety (IF 7.4) Pub Date : 2022-05-10 Laura Nawijn, Richard Dinga, Moji Aghajani, Marie-José van Tol, Nic J. A. van der Wee, Andreas Wunder, Dick J. Veltman, Brenda W. H. J. Penninx
Comorbid anxiety disorders and anxious distress are highly prevalent in major depressive disorder (MDD). The presence of the DSM-5 anxious distress specifier (ADS) has been associated with worse treatment outcomes and chronic disease course. However, little is known about the neurobiological correlates of anxious distress in MDD.
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What role for cognitive remediation in the treatment of depressive symptoms? A superiority and noninferiority meta-analysis for clinicians Depression Anxiety (IF 7.4) Pub Date : 2022-05-10 Antonella Sociali, Marta Borgi, Mauro Pettorruso, Francesco Di Carlo, Chiara Di Natale, Antonio Tambelli, Maria C. Alessi, Laura Ciavoni, Alessio Mosca, Andrea Miuli, Stefano L. Sensi, Giovanni Martinotti, Francesca Zoratto, Massimo Di Giannantonio
Cognitive remediation (CR) is a promising technique in the treatment of the cognitive dimension of depression. The present study evaluated the potential of CR in treating depressive symptoms and provides practical information about its usefulness in clinical settings.
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Association of disease course and brain structural alterations in major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-04-29 Hannah Lemke, Lina Romankiewicz, Katharina Förster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinsträter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
The investigation of disease course-associated brain structural alterations in Major Depressive Disorder (MDD) have resulted in heterogeneous findings, possibly due to low reliability of single clinical variables used for defining disease course. The present study employed a principal component analysis (PCA) on multiple clinical variables to investigate effects of cumulative lifetime illness burden
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Subcortical shape in pediatric and adult obsessive-compulsive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-04-29 Zhishun Wang, Martine Fontaine, Marilyn Cyr, Moira A. Rynn, Helen Blair Simpson, Rachel Marsh, David Pagliaccio
Obsessive-compulsive disorder (OCD) implicates alterations in cortico-striato-thalamo-cortical and fronto-limbic circuits. Building on prior structural findings, this is the largest study to date examining subcortical surface morphometry in OCD.
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Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-04-14 Thomas S. Blank, Bernhard M. Meyer, Marie-Kathrin Wieser, Ulrich Rabl, Paul Schögl, Lukas Pezawas
Early-onset (EO) major depressive disorder (MDD) patients experience more depressive episodes and an increased risk of relapse. Thus, on a neurobiological level, adult EO patients might display brain structure and function different from adult-onset (AO) patients.
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Psychostimulant use and clinical outcome of repetitive transcranial magnetic stimulation treatment of major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-04-07 Scott A. Wilke, Crystal L. Johnson, Juliana Corlier, Katharine G. Marder, Andrew C. Wilson, Christopher M. Pleman, Andrew F. Leuchter
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). Psychostimulant medication use may be associated with improved rTMS outcomes, but a detailed understanding of these relationships is lacking.
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Associations of nonrestorative sleep and insomnia symptoms with incident depressive symptoms over 1–2 years: Longitudinal results from the Hispanic Community Health Study/Study of Latinos and Sueño Ancillary Study Depression Anxiety (IF 7.4) Pub Date : 2022-04-04 Kaori Saitoh, Takuya Yoshiike, Yoshiyuki Kaneko, Tomohiro Utsumi, Kentaro Matsui, Kentaro Nagao, Rei Otsuki, Sayaka Aritake-Okada, Hiroshi Kadotani, Kenichi Kuriyama, Masahiro Suzuki
Nonrestorative sleep (NRS), defined as insufficiently rested or refreshed sleep, is considered to play an important role in the development of depression. The aim of this study is to investigate the predictive ability of insomnia-related symptoms, including NRS, for incident depressive symptoms (DEPs) in a longitudinal manner.
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Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-03-31 Sofia Cussotto, Inês Delgado, Giovanni Oriolo, Jonas Kemper, Diane Begarie, Sandra Dexpert, Julie Sauvant, Marion Leboyer, Bruno Aouizerate, Rocío Martin-Santos, Martin Schaefer, Lucile Capuron
Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)−3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and in humans. However, few studies to date have investigated the role of PUFAs in antidepressant response. The primary aim of this study was to assess the link between baseline PUFA composition and
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Dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the COVID-19 pandemic: A network analysis Depression Anxiety (IF 7.4) Pub Date : 2022-03-28 Shin Tae Kim, Jun Ho Seo, Sangmin Lee, Sumoa Jeon, Chun Il Park, Se Joo Kim, Jee In Kang
The 2019 coronavirus disease (COVID-19) pandemic has had a profound impact on the mental health of people worldwide. This study examined dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the pandemic using the coronavirus anxiety scale (CAS) and examined the relationship between coronavirus anxiety and clinical symptoms using network analysis.
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A temporal analysis of mental health symptoms relative to separation from the military Depression Anxiety (IF 7.4) Pub Date : 2022-03-28 Ben Porter, Felicia R. Carey, Kimberly A. Roenfeldt, Rudolph P. Rull, Carl A. Castro
The transition from military to civilian life is a dramatic change that is often stressful for veterans. However, little is known regarding how mental health symptoms fluctuate in the period leading up to and following separation from the military.
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Does coping reduce suicidal urges in everyday life? Evidence from a daily diary study of adolescent inpatients Depression Anxiety (IF 7.4) Pub Date : 2022-03-24 Nadia Al-Dajani, Adam G. Horwitz, Ewa K. Czyz
Youth suicide has been increasing at an alarming rate. Identifying how youth at risk for suicide cope with daily distress and suicidal thoughts could inform prevention and intervention efforts. We investigated the relationship between previous-day coping and next-day suicidal urge intensity in a high-risk adolescent sample for a 4-week period. We also investigated the influence of adolescents' average
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Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Sage E. Hawn, Zoe Neale, Erika J. Wolf, Xiang Zhao, Meghan Pierce, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark Logue, Mark W. Miller
Posttraumatic stress disorder (PTSD) is associated with inflammation and various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been implicated in mechanisms of inflammation and anxiety, and methylation at a particular locus in this gene (cg10636246) has previously been shown to influence the association between PTSD and elevated C-reactive protein levels in blood.
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Meditation-based lifestyle modification in mild to moderate depression—A randomized controlled trial Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Holger C. Bringmann, Andreas Michalsen, Michael Jeitler, Christian S. Kessler, Benno Brinkhaus, Stefan Brunnhuber, Peter Sedlmeier
Depression is a global key challenge in mental health care. The implementation of effective, low-risk and cost-effective interventions to reduce its disease burden is a necessity. The aim of this study was to investigate the efficacy of the new Meditation-Based Lifestyle Modification (MBLM) program, a “second-generation” mindfulness-based intervention, in depressive outpatients.
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Atomoxetine in comorbid ADHD/PTSD: A randomized, placebo controlled, pilot, and feasibility study Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Zhewu Wang, Zachary D. Zuschlag, Ursula S. Myers, Mark Hamner
PTSD and ADHD often occur comorbidly. Research indicates that the cognitive deficits in PTSD may be related to the same disturbance of fronto-temporal systems as observed in ADHD, and ADHD has been shown to impact PTSD treatment outcomes. The presented study evaluated the safety and efficacy of atomoxetine in Veterans with comorbid ADHD/PTSD.
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Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Johannah Bashford-Largo, Ru Zhang, Avantika Mathur, Jaimie Elowsky, Amanda Schwartz, Matthew Dobbertin, Robert James R. Blair, Karina S. Blair, Sahil Bajaj
Widespread structural alterations have been shown to be implicated in individuals with generalized anxiety disorder (GAD). However, there have been inconsistent findings in cortical volume (CV) differences. Most structural neuroimaging studies looking at GAD used region-based approach with relatively small sample sizes, let alone be specific to adolescents with GAD. We believe this is the first study
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Physical multimorbidity and depression: A mediation analysis of influential factors among 34,129 adults aged ≥50 years from low- and middle-income countries Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Lee Smith, Jae Il Shin, Laurie Butler, Yvonne Barnett, Hans Oh, Louis Jacob, Karel Kostev, Nicola Veronese, Pinar Soysal, Mark Tully, Guillermo F. López Sánchez, Ai Koyanagi
There is a scarcity of literature on the association between physical multimorbidity (i.e., ≥2 chronic physical conditions) and depression among older adults, especially from low- and middle-income countries (LMICs). In addition, the mediators in this association are largely unknown. Therefore, we aimed to examine this association among adults aged ≥50 years from six LMICs (China, Ghana, India, Mexico
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Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants Depression Anxiety (IF 7.4) Pub Date : 2022-03-21 Emily Olfson, Eli R. Lebowitz, Grace Hommel, Neha Pashankar, Wendy K. Silverman, Thomas V. Fernandez
Genetic factors contribute to the development of anxiety disorders, yet few risk genes have been previously identified. One genomic approach that has achieved success in identifying risk genes in related childhood neuropsychiatric conditions is investigations of de novo variants, which has yet to be leveraged in childhood anxiety disorders.
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Postpartum hemorrhage and postpartum depressive symptoms: A retrospective cohort study Depression Anxiety (IF 7.4) Pub Date : 2022-02-15 Kewei Wang, Jun Qiu, Liping Meng, Xin Lai, Zhenzhen Yao, Songxu Peng
Many psychological and obstetrical factors contribute to the development of postpartum depression. However, little is known about how postpartum hemorrhage (PPH) influences postpartum depressive symptoms. This study explored the relationship between PPH and postpartum depressive symptoms in the Chinese population.
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Absence of early mood improvement as a robust predictor of rTMS nonresponse in major depressive disorder Depression Anxiety (IF 7.4) Pub Date : 2022-01-06 Alex M. Mirman, Juliana Corlier, Andrew C. Wilson, Reza Tadayonnejad, Katharine G. Marder, Christopher M. Pleman, David E. Krantz, Scott A. Wilke, Jennifer G. Levitt, Nathaniel D. Ginder, Rashi Ojha, Zafiris J. Daskalakis, Andrew F. Leuchter, Jonathan C. Lee
Symptoms of major depressive disorder (MDD) are reported to change early in treatment with repetitive transcranial magnetic stimulation (rTMS). We evaluated early changes in sleep, anxiety, and mood as predictors of nonresponse to rTMS treatment.
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Group autonomy enhancing treatment versus cognitive behavioral therapy for anxiety disorders: A cluster-randomized clinical trial Depression Anxiety (IF 7.4) Pub Date : 2021-12-24 Laura E. Kunst, Joyce Maas, Anton J. L. M. van Balkom, Marcel A. L. M. van Assen, Brenda Kouwenhoven, Marrie H. J. Bekker
Although cognitive behavioral therapy (CBT) is effective in the treatment of anxiety disorders, few evidence-based alternatives exist. Autonomy enhancing treatment (AET) aims to decrease the vulnerability for anxiety disorders by targeting underlying autonomy deficits and may therefore have similar effects on anxiety as CBT, but yield broader effects.
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The effect of loneliness and social support on the course of major depressive disorder among adults aged 50 years and older: A longitudinal study Depression Anxiety (IF 7.4) Pub Date : 2022-01-14 Aina Gabarrell-Pascuet, María V. Moneta, José L. Ayuso-Mateos, Marta Miret, Elvira Lara, Josep M. Haro, Beatriz Olaya, Joan Domènech-Abella
Previous research indicates that social support, loneliness, and major depressive disorder (MDD) are interrelated. Little is known about the potential pathways among these factors, in particular in the case of adults aged 50 years and older and suffering from MDD. The objective was to investigate whether loneliness mediates the association between low social support and recurrent episodes of MDD.
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Prevalence and correlates of pain and associated depression among community-dwelling older adults: Cross-sectional findings from LASI, 2017–2018 Depression Anxiety (IF 7.4) Pub Date : 2021-12-30 Thalil Muhammad, Muhammed Rashid
Health practitioners often meet older persons suffering both from pain and depression. The study aimed to examine the factors associated with pain among older individuals and its association with major depression. In addition, the interaction between self-rated health (SRH), wealth status, and pain that is associated with depression are explored.
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Efficacy of D-cycloserine augmented brief intensive cognitive-behavioural therapy for paediatric obsessive-compulsive disorder: A randomised clinical trial Depression Anxiety (IF 7.4) Pub Date : 2022-01-27 Lara J. Farrell, Allison M. Waters, Evelin Tiralongo, Sharna Mathieu, Matthew McKenzie, Vinay Garbharran, Robert S. Ware, Melanie J. Zimmer-Gembeck, Harry McConnell, Cassie Lavell, Jacinda Cadman, Thomas H. Ollendick, Jennifer L. Hudson, Ronald M. Rapee, Brett McDermott, Daniel Geller, Eric A. Storch
To examine the efficacy of weight-adjusted D-cycloserine (DCS) (35 or 70 mg) relative to placebo augmentation of intensive exposure therapy for youth with obsessive-compulsive disorder (OCD) in a double-blind, randomised controlled trial, and examine whether antidepressant medication or patient age moderated outcomes.
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A clinical trial comparing trauma-informed guilt reduction therapy (TrIGR), a brief intervention for trauma-related guilt, to supportive care therapy Depression Anxiety (IF 7.4) Pub Date : 2022-01-25 Sonya B. Norman, Christy Capone, Kaitlyn E. Panza, Moira Haller, Brittany C. Davis, Paula P. Schnurr, M. Tracie Shea, Kendall Browne, Gregory J. Norman, Ariel J. Lang, Alexander C. Kline, Shahrokh Golshan, Carolyn B. Allard, Abigail Angkaw
Trauma-related guilt is common, associated with posttraumatic mental health problems, and can persist after posttraumatic stress disorder (PTSD) treatment. We compared the efficacy of two six-session psychotherapies, Trauma-Informed Guilt Reduction (TrIGR) and Supportive Care Therapy (SCT), for reducing trauma-related guilt. TrIGR helps patients accurately appraise their role in the trauma and re-engage
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Symptom-level networks of youth- and parent-reported depression and anxiety in a transdiagnostic clinical sample Depression Anxiety (IF 7.4) Pub Date : 2022-01-24 Hannah L. Grassie, Sarah M. Kennedy, Elizabeth R. Halliday, Sierra A. Bainter, Jill Ehrenreich-May
Depression and anxiety disorders confer a significant public health concern for youth and their co-occurrence places youth at a higher risk for poorer psychosocial outcomes. In the present study, we use network analysis to investigate the role of and interactions among individual depression and anxiety symptoms in a treatment-seeking clinical sample.