Purpose The main aim was to evaluate the measurement properties of the Family Needs Questionnaire-Revised (FNQ-R) in family members of individuals living with severe traumatic brain injury (TBI). Methods A total of 309 family members of individuals with severe TBI from Colombia, Denmark, Mexico, Norway and Spain participated. Rasch analysis of the FNQ-R and its 6 subscales was conducted. Results The

Background Recent studies suggest that late recovery from vegetative state (VS) is more prevalent today than previously thought. This study examined the decline in the rate of recovery from VS with time after admission to rehabilitation, and established a new time frame, in which the odds of recovery from VS remain substantial. Methods Data of 206 patients with VS after traumatic and non-traumatic

Objective To examine the extent to which race/ethnicity, length of rehabilitation hospital stay (LOS), and payer source contribute to functional status following inpatient rehabilitation in children with acquired brain injury (ABI). Design Retrospective cohort study from a pediatric rehabilitation hospital including 485 individuals with ABI. Methods Functional Independence Measure for Children (WeeFIM)

Primary objective: The objective of this study was to design an instrument to screen for burden in the daily life of both the client with acquired brain injury (ABI) and their nonprofessional caregiver. Research Design: Exploratory research Methods and Procedures: Based on a survey amongst stakeholder organizations, the FINAH-instrument is designed as a digital self-assessment questionnaire, based

Objectives To evaluate how blast exposure impacts peripheral biomarkers in military personnel enrolled in 10-day blast training. Methods On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain

Primary Objective: Chemokine C-C motif ligand 2 (CCL2) plays a critical role in inflammation-related diseases in the central nervous system (CNS). However, the role of CCL2 in ischemic stroke remains unclear. Research Design: To investigate the role of CCL2 in ischemic stroke, we performed oxygen–glucose deprivation (OGD) on human brain astrocytes. Methods and Procedures: To assess cell proliferation

Objective There is enormous research and clinical interest in blood-based biomarkers of mild traumatic brain injury (MTBI) sustained in sports, daily life, or military service. We examined the reliability of a commercially available assay for S100B used on the same samples by two different laboratories separated by 2 years in time. Methods and Procedures A cohort of 163 adult patients (head CT-scanned

Objectives To analyze the influences of mild and severe intracranial hypertension on cerebral autoregulation (CA). Patients and Methods Duroc piglets were monitored with an intracranial pressure (ICP) catheter. Intracranial hypertension was induced via infusion of 4 or 7 ml of saline solution by a bladder catheter that was inserted into the parietal lobe. The static cerebral autoregulation (sCA) index

Purpose This study was primarily aimed at establishing the incidence and impact of hypotension in patients with blunt traumatic brain injury based on National Trauma Registry Database. Methods A retrospective cohort study using the National Trauma Registry was conducted. Patients with TBI following blunt mechanisms of injury were examined, comparing those with and without hypotension (SBP < 90 mm Hg)

Objectives We imaged the dentato-rubro-thalamic tract (DRTT) and cortico-ponto-cerebellar tract (CPCT) using diffusion tensor tractography (DTT) to evaluate the cortico-cerebellar-cortical circuit in a patient with tremor in both hands after mild TBI. We found bilateral DRTT injury in the DTT. Method A 50-year-old male presented with action tremor in both hands 1 week after mild TBI. One month before

Purpose The aim of this study is to assess the association between the Computed Tomography (CT) findings on admission, according to the Helsinki computed tomography CT score, and patient’s Quality of Life (QoL) following traumatic brain injury (TBI) in Lebanon. Methods A retrospective study was performed on 49 males suffering from war induced TBI. Participants were stratified into two groups based

Primary Objectives The aim of this paper was to conduct a review of the misconception literature relating to traumatic brain injury (TBI) and to critically review the comprehensiveness, psychometric properties and other qualities of existing scales designed to measure knowledge and misconceptions of TBI. Methods Terms relating to misconceptions, misconception scales, public perceptions and traumatic

Objectives To investigate criteria acute care interdisciplinary providers use to select discharge destination for patients with traumatic brain injury (TBI). Design Cross-sectional, exploratory survey study. Methods Data were collected from interdisciplinary providers at a U.S. Level I trauma centre via electronic survey. We invited 199 providers to participate and 27 responded (13.5% response rate)

Objectives Mild traumatic brain injury (mTBI) is a controversial and under-researched area, despite most traumatic brain injuries being classed as mild. Our objective was to review the evidence underpinning these approaches to treat mTBI including educational, psychological, rehabilitative and pharmacological approaches and discuss their efficacy. Methods A systematic review of literature was carried

Primary Objective This study determined whether initial GCS score, head CT results, cognitive performance on IMPACT testing, or APOE genotype most effectively predicted 1-month functional outcome after mild traumatic brain injury (mTBI). This study tested the hypotheses that participants with poor performance on initial cognitive testing and those with an APOEe4 genotype would exhibit a poorer 1-month

Objectives To investigate the oral health status in patients with acquired brain injury (ABI) admitted at neurorehabilitation setting. Methods 132 individuals with ABI were examined within their first week of admission. Individuals’ socio-behavioral history, length of stay in acute care etc. were recorded. Comprehensive clinical oral examination consisting of acute conditions [dental plaque, bleeding

Objective The objective of this study is to describe concussion reporting and return to learn and play among high school students. Methods Self-reported survey data of 1,999 New England private preparatory high school students who played sports or engaged in recreational activities were collected in 2018. Descriptive and bivariate statistics are presented. Results Three in ten respondents (31.4%) reported

Objective With the increasing global prevalence of acquired brain injury (ABI), the burden of visual problems as a sequelae to ABI is on the rise. This study reports the visual profile of patients with ABI seen in Neuro-Optometry Clinic (NOC) at a tertiary eye-care center in Southern India. Methods A retrospective study was carried out between January 2014 and December 2015. Medical records of patients

ABSTRACT Objective To determine knowledge, attitudes, and behavior toward concussion in cyclists and to identify predictors of concussion knowledge. Methods Cycling organizations sent members a web link to online information about the study and a questionnaire. Anyone aged >16 years, living in New Zealand and engaged in a cycling activity was invited to participate. The 36-item questionnaire included

Primary Objective Research is increasingly demonstrating the significant impact that non-medical factors can have on outcomes of service members (SMs) with mild traumatic brain injury (mTBI). Thus, the current study examined which demographic, TBI-related factors, and psychological variables are most predictive of functional outcomes. Research Design Retrospective database analysis from medical chart

Objectives The need for support following traumatic brain injury (TBI) is well documented. Yet the evidence is limited about the types of support required, how support needs change over time, and the effect of level of disability. This study addresses this limitation in the evidence. Method Longitudinal design with a state-wide inception cohort of 131 people with severe TBI. Support needs were assessed

ABSTRACT Objective Post-concussion syndrome (PCS) occurs following mild traumatic brain injury (mTBI). Patients with mTBI are often assessed using self-report instruments that rely on perception of current symptoms compared to how they felt and functioned pre-injury. The objective was to examine reliability of patients’ post-injury reporting of their pre-injury symptoms. Methods We included two control

Purpose Numbers of traumatic brain injury (TBI) are increasing, and with suicidality post-injury presenting at 3–4 times higher than in the general population, understanding this is crucial in reducing a devastating outcome. Given the lack of literature, this study investigated the experiences of living with suicidality after TBI. Methods Interview data from nineteen participants with TBI from a Brain

Objective To investigate current speech pathology practice regarding working with friends. Method An online survey was conducted with 68 speech pathologists who worked with TBI across metropolitan and rural settings in Australia. The survey investigated the reasons speech pathologists work with friends, barriers to working with friends and perceptions of successful friendships post TBI. Descriptive

Purpose As part of a larger study to test the efficacy of the Concussion Coach cell phone application for patients with post-concussion symptoms, qualitative data were gathered to assess barriers and facilitators for app use and differences in use of the app among those who declined or improved in symptom severity, or were low-use users. Materials and Methods Using a prospective descriptive study design

Primary Objective The primary objective of this study was to explore the pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats. Research Design Weight drop model of traumatic brain injury. Methods and Procedures After TBI, the animals were treated with doxycycline (50 and 100 mg/kg; p.o), tocopherol (5 and 10 mg/kg; p.o) alone

Aim To evaluate the combined effect of compensation therapy and functional training on working memory (WM) in patients with acquired injury and chronic cognitive deficits by investigating the dose-response relationship and specificity of transfer effects. Research design Double-blind randomized controlled trial. Methods All patients underwent 4 weeks of compensation therapy in a day-care setting. In

Objectives To explore the relationship between shame and self-discrepancies and the extent that these factors predict adjustment after an acquired brain injury (ABI). Method 62 participants with an ABI completed the following self-report qualitative questionnaires: the Hospital Anxiety and Depression Scale, the Quality of Life after Brain Injury Scale, the Internalized Shame Scale, and the Head Injury

Primary objective The purpose of this study is to explore changes in mood in youth with persistent post-concussion symptoms following participation in a six-week active rehabilitation program. Research design A pre-post test design was used. Methods and procedures Participants (N = 40 children and adolescents with concussion symptoms >2 weeks post-injury) were recruited from the concussion services

Objectives 1. Evaluate reliability and construct validity of the newly-developed Family Needs Questionnaire – Pediatric (FNQ-P), a 40-item measure assessing the extent to which family’s needs are met after a child has an acquired brain injury (ABI). 2. Explore the impact of selected child characteristics on FNQ-P scores. Research Design: Measurement study Methods: Parents/caregivers of children with

Background Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application of amantadine in UWS after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the treatment of UWS resulting from a severe cerebral hemorrhage. Methods We observed the

Objective Relationship continuity/discontinuity refers to whether a spouse/partner experiences their current relationship with someone with an acquired brain injury (ABI) as a continuation of their loving pre-injury relationship or as radically changed. The aim of this study was to adapt a questionnaire measure of continuity/discontinuity from dementia research for use in an ABI context and to evaluate

Objectives The growing concern over player safety and long-term health effects of sport-related concussion (SRC) led the Atlantic Coast Conference (ACC) to implement the medical observer, whose primary job is to identify SRCs not seen by sideline medical staff. The primary aim of this survey was to determine if the MO identifies SRCs the sideline medical staff missed during gameplay. Methods The authors

Objective To assess variables associated with decannulation in patients with traumatic brain injury (TBI). Participants 79 patients with TBI requiring tracheostomy and ICU admission from January 1st to December 31st, 2014. Design Retrospective analysis. Measures Patients decannulated prior to 90 days were compared with patients who remained cannulated. Two Cox Proportional Hazards models were used

Objective In this pilot study, we investigated the impact of a sport-related concussion (SRC) on the ability to form cognitive maps, mental representations of the environment that are critical for spatial orientation and navigation. Participants We recruited 18 adolescent hockey players suffering from a SRC, and 19 age, sex and handedness-matched hockey players with no history of concussion. Main measure

Objective To compare the impacts of yoga-based physical therapy versus a seated rest within the context of standard rehabilitation practice on sleep, heart rate variability (HRV), anxiety, and fatigue during acute traumatic brain injury (TBI) rehabilitation. Methods Eleven individuals participated in this crossover study involving the following interventions in a randomized order: group yoga-based

Objective To review the historical, clinical, radiographic, and outcome characteristics of individuals diagnosed with an acquired brain injury (ABI) due to cerebral fat embolism syndrome (CFES) with and without features of traumatic brain injury (TBI) Methods A retrospective chart review of individuals with the diagnosis of CFES admitted to an ABI rehabilitation program. Cases were divided into two

(2020). Discontinuation of artificial nutrition and hydration and covert cognition. Brain Injury: Vol. 34, No. 8, pp. 1135-1135.

(2020). COVID-19 neuropsychological factors and considerations within the acute physical medicine and rehabilitation setting. Brain Injury: Vol. 34, No. 8, pp. 1136-1137.

Objectives The aim of this research was to assess cognitive-motor interactions though dual tasks of working memory in patients with traumatic brain injury (TBI) and control subjects. Methods: Twenty patients with chronic TBI with good functional level and 19 matched healthy controls performed dual working memory tasks (1-back numeric and 1-back spatial (S)) while sitting, standing, and walking. The

Background Peer support groups can be a way to obtain support, problem solve, and widen social networks. However, there has been no systematic literature review examining the evidence for the use of peer support groups after an acquired brain injury (ABI). Objective This review sought to systematically evaluate the evidence for (1) the psychosocial effectiveness, and (2) the experience of peer support

Objective To assess the proportion of pediatric patients who develop post-traumatic stress disorder (PTSD) attributed to traumatic brain injury (TBI). Methods PubMed and Embase were searched from database inception until January 26, 2019. Two independent investigators screened titles, abstracts, and subsequently, full-text articles. Following this, the same investigators also extracted data relevant

Objective To explore which intraventricular fibrinolytic agent – urokinase (UK) or recombinant tissue plasminogen activator (rt-PA) – combined with extraventricular drainage (EVD) is most suitable for patients with spontaneous intraventricular hemorrhage (IVH). Patients and Methods We searched PubMed, MEDLINE, OVID, Embase, and Cochrane Library databases for relevant articles and assessed their quality

Study Design Prospective longitudinal cohort study Background Adolescent athletes may be more susceptible to the long-term effects of mild traumatic brain injury (mTBI). A diagnostic and prognostic neuromarker may optimize management and return-to-activity decision-making in athletes who experience mTBI. Objective Measure an event-related potential (ERP) component captured with electroencephalography

Objective The Modified Mini-Mental State Examination (3MS) could provide useful information about cognitive status in traumatic brain injury (TBI), yet has not been validated in this population. We studied the reliability, construct validity, clinical responsiveness, and cognitive impairment classification-ability of the 3MS compared to the Mini-Mental State Examination (MMSE). Methods Adult participants

Objective: To estimate national frequency of posttraumatic epilepsy (PTE) after severe traumatic brain injury (TBI) and assess injury severity (Glasgow Coma Scale (GCS) and posttraumatic amnesia (PTA)) as prognostic factors for PTE. Methods Data on patients ≥18 years surviving severe TBI 2004–2016 were retrieved from the Danish Head Trauma Database (n = 1010). The cumulative incidence proportion (CIP)

Primary objective: The neurophysiological effects of pediatric concussion several years after injury remain inadequately characterized. The objective of this study was to determine if a history of concussion was associated with BOLD response differences during an n-back working memory task in youth. Research Design: Observational, cross-sectional. Methods and Procedures: Participants include 52 children

Objective Describe the extent to which concussion education provided to coaches of US high school and youth sport is inclusive of information necessary for them to engage in target behaviors related to the prevention, identification and management of concussion. Methods Sport organizations included in the sample were US state high school governing bodies and national governing bodies (NGBs) for youth

Objective To assess the validity of the Westmead PTA scale in school-aged children treated with opiate analgesics. Method Twenty-eight hospitalized children without brain injury, aged between 8 and 16 years treated with opiate analgesics for pain relief following surgery were tested on the Westmead PTA scale. Pain and stress levels were also self-reported each day. Results Only 29% (n = 7) of children

Objective To assess a simple technology solution to support basic communication and leisure in people with neurological disorders, extensive motor impairment, and absence of speech. Design The design was a non-concurrent multiple baseline across participants. Methods The study included eight participants and assessed a technology setup including a Samsung Galaxy Tab S2 LTE tablet and a Samsung Galaxy

ABSTRACT Objectives The purpose of our investigation was to compare post-concussion symptom profiles and postural control measures among female youth artistic athletes (gymnasts and cheerleaders) relative to female ball sport athletes (volleyball or basketball). Methods/Findings We compared 27 artistic athletes (median age = 15.0 years; evaluated median = 13 days post-injury) and 49 ball sport athletes

Primary objective To explore the clinical practice of communication partner training by Speech and Language Therapists for people with traumatic brain injury in the UK. Study design Online 97-item survey which addressed the practice of training both familiar and unfamiliar communication partners, and barriers and facilitators to implementation informed by the Theoretical Domains Framework. Participants

Primary objective The purpose of this study was to investigate the influence of perceived personal responsibility for an acquired ABI (ABI) on shame, and whether self-compassion moderates this relationship. We hypothesized that people who perceived themselves to be responsible for their injury would have high levels of shame and poorer recovery outcomes. Research design A mixed-methods design was employed

ABSTRACT Objective Hyperoxia is associated with adverse outcome in severe traumatic brain injury (TBI). This study explored differences in patient classification of oxygen exposure by PaO2 cutoff and cumulative area-under-the-curve (AUC) analysis. Methods Retrospective, explorative study including children (<18 years) with accidental severe TBI (2002–2015). Oxygen exposure analysis used three PaO2

Background Detection of brain-specific miRNAs in the peripheral blood could serve as a surrogate marker of traumatic brain injury (TBI). Here, we systematically identified brain-enriched miRNAs, and tested their utility as TBI biomarkers in the acute phase of care. Methods Publically available microarray data generated from 29 postmortem human tissues were used to rank 1,364 miRNAs in terms of their

Background To explore the combined influences of temperature-sensitive bone mesenchymal stem cells (tsBMSCs) and mild hypothermia (MH) on neurological function and glucose metabolism in rats with severe traumatic brain injury (TBI). Methods SD rats were randomly divided into sham, TBI, TBI + MH, TBI + BMSCs and TBI + MH +tsBMSCs groups. Then, the brain water content, serum-specific proteins (S100β

Primary Objective Traumatic brain injury (TBI) is associated with higher incidence of neurodegenerative disease and the effects of aging appear more pronounced after TBI. This paper examines the potential interaction of aging, TBI, and change in male testosterone production. Methods and Procedures An abbreviated review of literature documenting hypogonadism after TBI is provided. Potential mechanisms

(2020). Family experience of brain injury: surviving, coping, adjusting. Brain Injury: Vol. 34, No. 7, pp. 988-988.

(2020). Family experience of brain injury: surviving, coping, adjusting. Brain Injury. Ahead of Print.

OBJECTIVE To evaluate the efficacy of a novel intervention facilitating volunteer activity to improve well-being in individuals with traumatic brain injury (TBI). DESIGN Randomized two-arm controlled trial, with a wait-list control condition (ClinicalTrials.gov NCT#01728350). SETTING Community-based setting. PARTICIPANTS Seventy-four community-dwelling individuals at least 1-year post TBI, who had