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The unconditioned fear response in vertebrates deficient in dystrophin Prog. Neurobiol. (IF 6.7) Pub Date : 2024-03-12 Saba Gharibi, Cyrille Vaillend, Angus Lindsay
Dystrophin loss due to mutations in the Duchenne muscular dystrophy (DMD) gene is associated with a wide spectrum of neurocognitive comorbidities, including an aberrant unconditioned fear response to stressful/threat stimuli. Dystrophin-deficient animal models of DMD demonstrate enhanced stress reactivity that manifests as sustained periods of immobility. When the threat is repetitive or severe in
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Fundamentals of sleep regulation: Model and benchmark values for fractal and oscillatory neurodynamics Prog. Neurobiol. (IF 6.7) Pub Date : 2024-03-07 Róbert Bódizs, Bence Schneider, Péter P. Ujma, Csenge G. Horváth, Martin Dresler, Yevgenia Rosenblum
Homeostatic, circadian and ultradian mechanisms play crucial roles in the regulation of sleep. Evidence suggests that ratios of low-to-high frequency power in the electroencephalogram (EEG) spectrum indicate the instantaneous level of sleep pressure, influenced by factors such as individual sleep-wake history, current sleep stage, age-related differences and brain topography characteristics. These
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Accumulation of NMDA receptors in accumbal neuronal ensembles mediates increased conditioned place preference for cocaine after prolonged withdrawal Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-22 Ziqing Huai, Bing Huang, Guanhong He, Haibo Li, Yonghui Liu, Qiumin Le, Feifei Wang, Lan Ma, Xing Liu
Cue-induced cocaine craving gradually intensifies following abstinence, a phenomenon known as the incubation of drug craving. Neuronal ensembles activated by initial cocaine use, are critically involved in this process. However, the mechanisms by which neuronal changes occurring in the ensembles after withdrawal contribute to incubation remain largely unknown. Here we labeled neuronal ensembles in
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Epilepsy and demyelination: towards a bidirectional relationship Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-18 Jiayi Li, Honggang Qi, Yuzhou Chen, Xinjian Zhu
Demyelination stands out as a prominent feature in individuals with specific types of epilepsy. Concurrently, individuals with demyelinating diseases, such as multiple sclerosis (MS) are at a greater risk of developing epilepsy compared to non-MS individuals. These bidirectional connections raise the question of whether both pathological conditions share common pathogenic mechanisms. This review focuses
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A Cytoskeleton Symphony: Actin and Microtubules in Microglia Dynamics and Aging Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-16 Renato Socodato, João B. Relvas
Microglia dynamically reorganize their cytoskeleton to perform essential functions such as phagocytosis of toxic protein aggregates, surveillance of the brain parenchyma, and regulation of synaptic plasticity during neuronal activity bursts. Recent studies have shed light on the critical role of the microtubule cytoskeleton in microglial reactivity and function, revealing key regulators like cyclin-dependent
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The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-15 Valentina La Cognata, Giovanna Morello, Maria Guarnaccia, Sebastiano Cavallaro
Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease with complex genetic basis and still no clear etiology. Multiple intertwined layers of immune system-related dysfunctions and neuroinflammatory mechanisms are emerging as substantial determinants in ALS onset and progression. In this review, we collect the increasingly arising evidence implicating four main CXC chemokines/cognate
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Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-15 Riccardo Maccioni, Caterina Travisan, Jack Badman, Stefania Zerial, Annika Wagener, Yuniesky Andrade-Talavera, Federico Picciau, Caterina Grassi, Gefei Chen, Laetitia Lemoine, André Fisahn, Richeng Jiang, Regina Fluhrer, Torben Mentrup, Bernd Schröder, Per Nilsson, Simone Tambaro
Alzheimer's disease (AD) is a multifactorial disorder driven by abnormal amyloid β-peptide (Aβ) levels. In this study, we investigated the role of presenilin-like signal peptide peptidase-like 2b (SPPL2b) in AD pathophysiology and its potential as a druggable target within the Aβ cascade. Exogenous Aβ42 influenced SPPL2b expression in human cell lines and acute mouse brain slices. SPPL2b and its AD-related
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Mesoscale organization of ventral and dorsal visual pathways in macaque monkey revealed by 7T fMRI Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-02 Jianbao Wang, Xiao Du, Songping Yao, Lihui Li, Hisashi Tanigawa, Xiaotong Zhang, Anna Wang Roe
In human and nonhuman primate brains, columnar (mesoscale) organization has been demonstrated to underlie both lower and higher order aspects of visual information processing. Previous studies have focused on identifying functional preferences of mesoscale domains in specific areas; but there has been little understanding of how mesoscale domains may cooperatively respond to single visual stimuli across
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Contralateral delay activity and alpha lateralization reflect retinotopic and screen-centered reference frames in visual memory Prog. Neurobiol. (IF 6.7) Pub Date : 2024-02-02 Wanja A. Mössing, Svea C.Y. Schroeder, Anna Lena Biel, Niko A. Busch
The visual system represents objects in a lateralized manner, with contralateral cortical hemispheres responsible for left and right visual hemifields. This organization extends to visual short-term memory (VSTM), as evidenced by electrophysiological indices of VSTM maintenance: contralateral delay activity (CDA) and alpha-band lateralization. However, it remains unclear if VSTM represents object locations
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The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-26 Mario O. Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M. Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A. Cavieres, Tammy P. Pástor, Juan S. Bonifacino, Gonzalo A. Mardones, María-Paz Marzolo
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The glymphatic system and Amyotrophic lateral sclerosis Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-22 Andrew Eisen, Maiken Nedergaard, Emma Gray, Matthew C. Kiernan
The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is applicable for TDP-43 and glutamate, both major elements in disease pathogenesis. Flow is propelled by arterial pulsation, respiration, posture, as well as the positioning and proportion of aquaporin-4 channels (AQP4)
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Digging into the intrinsic capacity concept: Can it be applied to Alzheimer’s disease? Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-22 Susana López-Ortiz, Giuseppe Caruso, Enzo Emanuele, Héctor Menéndez, Saúl Peñín-Grandes, Claudia Savia Guerrera, Filippo Caraci, Robert Nisticò, Alejandro Lucia, Alejandro Santos-Lozano, Simone Lista
Historically, aging research has largely centered on disease pathology rather than promoting healthy aging. The World Health Organization’s (WHO) policy framework (2015–2030) underscores the significance of fostering the contributions of older individuals to their families, communities, and economies. The WHO has introduced the concept of intrinsic capacity (IC) as a key metric for healthy aging, encompassing
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Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson’s disease. Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-20 A Muñoz, N Benseny-Cases, S Guha, , KA Caldwell, GA Caldwell, L Agulló, VJ Yuste, A Laromaine, E Dalfó
Patients with Parkinson’s disease (PD) display non-motor symptoms arising prior to the appearance of motor signs and before a clear diagnosis. Motor and non-motor symptoms correlate with progressive deposition of the protein alpha-synuclein (Asyn) both within and outside of the central nervous system, and its accumulation parallels neurodegeneration. The genome of Caenorhabditis elegans does not encode
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Barrel cortex development lacks a key stage of hyperconnectivity from deep to superficial layers in a rat model of Absence Epilepsy Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-19 Simona Plutino, Emel Laghouati, Guillaume Jarre, Antoine Depaulis, Isabelle Guillemain, Ingrid Bureau
During development of the sensory cortex, the ascending innervation from deep to upper layers provides a temporary scaffold for the construction of other circuits that remain at adulthood. Whether an alteration in this sequence leads to brain dysfunction in neuro-developmental diseases remains unknown. Using functional approaches in a genetic model of Absence Epilepsy (GAERS), we investigated in barrel
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Predictable navigation through spontaneous brain states with cognitive-map-like representations Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-15 Siyang Li, Zhipeng Li, Qiuyi Liu, Peng Ren, Lili Sun, Zaixu Cui, Xia Liang
Just as navigating a physical environment, navigating through the landscapes of spontaneous brain states may also require an internal cognitive map. Contemporary computation theories propose modeling a cognitive map from a reinforcement learning perspective and argue that the map would be predictive in nature, representing each state as its upcoming states. Here, we used resting-state fMRI to test
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Grid codes underlie multiple cognitive maps in the human brain Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-15 Dong Chen, Nikolai Axmacher, Liang Wang
Grid cells fire at multiple positions that organize the vertices of equilateral triangles tiling a 2D space and are well studied in rodents. The last decade witnessed rapid progress in two other research lines on grid codes—empirical studies on distributed human grid-like representations in physical and multiple non-physical spaces, and cognitive computational models addressing the function of grid
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Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity Prog. Neurobiol. (IF 6.7) Pub Date : 2024-01-10 Xingliang Zhu, Yuyoung Joo, Simone Bossi, Ross A. McDevitt, Aoji Xie, Yue Wang, Yutong Xue, Shuaikun Su, Seung Kyu Lee, Nirnath Sah, Shiliang Zhang, Rong Ye, Alejandro Pinto, Yongqing Zhang, Kimi Araki, Masatake Araki, Marisela Morales, Mark P. Mattson, Henriette van Praag, Weidong Wang
The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex that can alter both DNA and RNA topology in animals. TOP3B mutations in humans are associated with schizophrenia, autism and cognitive disorders; and Top3b-null mice exhibit several phenotypes observed in animal models of psychiatric and cognitive disorders, including impaired
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ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-28 Mengping Wei, Lei Yang, Feng Su, Ying Liu, Xinyi Zhao, Lin Luo, Xinyue Sun, Sen Liu, Zhaoqi Dong, Yong Zhang, Yun Stone Shi, Jing Liang, Chen Zhang
Trafficking of α‐Amino‐3–hydroxy‐5–methylisoxazole‐4–propionic acid (AMPA) receptors (AMPARs), mediated by AMPAR interacting proteins, enabled neurons to maintain tuning capabilities at rest or active state. α/β-Hydrolase domain-containing 6 (ABHD6), an endocannabinoid hydrolase, was an AMPAR auxiliary subunit found to negatively regulate the surface delivery of AMPARs. While ABHD6 was found to prevent
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Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-21 Nicha Puangmalai, Nemil Bhatt, Alice Bittar, Cynthia Jerez, Nikita Shchankin, Rakez Kayed
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Phase of neural oscillations as a reference frame for attention-based routing in visual cortex Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-23 Ehsan Aboutorabi, Sonia Baloni Ray, Daniel Kaping, Farhad Shahbazi, Stefan Treue, Moein Esghaei
Selective attention allows the brain to efficiently process the image projected onto the retina, selectively focusing neural processing resources on behaviorally relevant visual information. While previous studies have documented the crucial role of the action potential rate of single neurons in relaying such information, little is known about how the activity of single neurons relative to their neighboring
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Dissecting neural circuits from rostral ventromedial medulla to spinal trigeminal nucleus bidirectionally modulating craniofacial mechanical sensitivity Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-22 Yang Xue, Siyi Mo, Yuan Li, Ye Cao, Xiaoxiang Xu, Qiufei Xie
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FAME4-associating YEATS2 knockdown impairs dopaminergic synaptic integrity and leads to seizure-like behaviours in Drosophila melanogaster Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-20 Luca Lo Piccolo, Ranchana Yeewa, Sureena Pohsa, Titaree Yamsri, Daniel Calovi, Jutarop Phetcharaburanin, Manida Suksawat, Thanaporn Kulthawatsiri, Vorasuk Shotelersuk, Salinee Jantrapirom
Familial adult myoclonus epilepsy (FAME) is a neurological disorder caused by a TTTTA/TTTCA intronic repeat expansion. FAME4 is one of the six types of FAME that results from the repeat expansion in the first intron of the gene YEATS2. Although the RNA toxicity is believed to be the primary mechanism underlying FAME, the role of genes where repeat expansions reside is still unclear, particularly in
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Pax3 induces target-specific reinnervation through axon collateral expression of PSA-NCAM Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-12 J. Sebastian Jara, Hasan X. Avci, Ioanna Kouremenou, Mohamed Doulazmi, Joelle Bakouche, Caroline Dubacq, Catherine Goyenvalle, Jean Mariani, Ann M. Lohof, Rachel M. Sherrard
Damaged or dysfunctional neural circuits can be replaced after a lesion by axon sprouting and collateral growth from undamaged neurons. Unfortunately, these new connections are often disorganized and rarely produce clinical improvement. Here we investigate how to promote post-lesion axonal collateral growth, while retaining correct cellular targeting. In the mouse olivocerebellar path, brain-derived
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Nanoparticle-mediated delivery of non-viral gene editing technology to the brain Prog. Neurobiol. (IF 6.7) Pub Date : 2023-12-01 Lucian Williams, Jessica Larsen
Neurological disorders pose a significant burden on individuals and society, affecting millions worldwide. These disorders, including but not limited to Alzheimer's disease, Parkinson's disease, and Huntington's disease, often have limited treatment options and can lead to progressive degeneration and disability. Gene editing technologies, including Zinc Finger Nucleases (ZFN), Transcription Activator-Like
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Configuration-sensitive face-body interactions in primate visual cortex Prog. Neurobiol. (IF 6.7) Pub Date : 2023-11-30 Yordanka Zafirova, Anna Bognár, Rufin Vogels
Traditionally, the neural processing of faces and bodies is studied separately, although they are encountered together, as parts of an agent. Despite its social importance, it is poorly understood how faces and bodies interact, particularly at the single-neuron level. Here, we examined the interaction between faces and bodies in the macaque inferior temporal (IT) cortex, targeting an fMRI-defined patch
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Neuroplasticity in levodopa-induced dyskinesias: An overview on pathophysiology and therapeutic targets Prog. Neurobiol. (IF 6.7) Pub Date : 2023-11-30 Francesco Bove, Benedetta Angeloni, Pasquale Sanginario, Paolo Maria Rossini, Paolo Calabresi, Riccardo Di Iorio
Levodopa-induced dyskinesias (LIDs) are a common complication in patients with Parkinson’s disease (PD). A complex cascade of electrophysiological and molecular events that induce aberrant plasticity in the cortico-basal ganglia system plays a key role in the pathophysiology of LIDs. In the striatum, multiple neurotransmitters regulate the different forms of physiological synaptic plasticity to provide
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Orbitofrontal intronic circular RNA from Nrxn3 mediates reward learning and motivation for reward Prog. Neurobiol. (IF 6.7) Pub Date : 2023-11-29 Konrad R. Dabrowski, Gabriele Floris, Aria Gillespie, Stephanie E. Sillivan
The orbitofrontal cortex (OFC) is a vital component of brain reward circuitry that is important for reward seeking behavior. However, OFC-mediated molecular mechanisms underlying rewarding behavior are understudied. Here, we report the first circular RNA (circRNA) profile associated with appetitive reward and identify regulation of 92 OFC circRNAs by sucrose self-administration. Among these changes
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EBP50 is a key molecule for the Schwann cell-axon interaction in peripheral nerves Prog. Neurobiol. (IF 6.7) Pub Date : 2023-11-07 Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Peripheral nerve injury disrupts the Schwann cell-axon interaction and the cellular communication between them. The peripheral nervous system has immense potential for regeneration extensively due to the innate plastic potential of Schwann cells (SCs) that allows SCs to interact with the injured axons and exert specific repair functions essential for peripheral nerve regeneration. In this study, we
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Cortical surface plasticity promotes map remodeling and alleviates tinnitus in adult mice Prog. Neurobiol. (IF 6.7) Pub Date : 2023-11-02 Sojeong Pak, Minseok Lee, Sangwon Lee, Huilin Zhao, Eunha Baeg, Sunggu Yang, Sungchil Yang
Tinnitus induced by hearing loss is caused primarily by irreversible damage to the peripheral auditory system, which results in abnormal neural responses and frequency map disruption in the central auditory system. It remains unclear whether and how electrical rehabilitation of the auditory cortex can alleviate tinnitus. We hypothesize that stimulation of the cortical surface can alleviate tinnitus
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Phase separation modulates the functional amyloid assembly of human CPEB3 Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-28 Daniel Ramírez de Mingo, Paula López-García, María Eugenia Vaquero, Rubén Hervás, Douglas V. Laurents, Mariano Carrión-Vázquez
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STED microscopy reveals dendrite-specificity of spines in turtle cortex Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-26 Jan A. Knobloch, Gilles Laurent, Marcel A. Lauterbach
Dendritic spines are key structures for neural communication, learning and memory. Spine size and shape probably reflect synaptic strength and learning. Imaging with superresolution STED microscopy the detailed shape of the majority of the spines of individual neurons in turtle cortex (Trachemys scripta elegans) revealed several distinguishable shape classes. Dendritic spines of a given class were
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Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-26 Archana Proddutur, Susan Nguyen, Chia-Wei Yeh, Akshay Gupta, Vijayalakshmi Santhakumar
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NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-12 Yuri Zilberter, Dennis R. Tabuena, Misha Zilberter
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile, major sporadic NDDs share many risk factors and exhibit similar pathologies in their early stages, indicating the existence of common initiation pathways. Glucose hypometabolism associated with oxidative stress is one such primary
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Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-12 R.J. Bufacchi, A. Battaglia-Mayer, G.D. Iannetti, R. Caminiti
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Adverse and compensatory neurophysiological slowing in Parkinson’s disease Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-11 Alex I. Wiesman, Jason da Silva Castanheira, Clotilde Degroot, Edward A. Fon, Sylvain Baillet, , Quebec Parkinson Network
Patients with Parkinson’s disease (PD) exhibit multifaceted changes in neurophysiological brain activity, hypothesized to represent a global cortical slowing effect. Using task-free magnetoencephalography and extensive clinical assessments, we found that neurophysiological slowing in PD is differentially associated with motor and non-motor symptoms along a sagittal gradient over the cortical anatomy
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The role of N-methyl-D-aspartate glutamate receptors in Alzheimer’s disease: From pathophysiology to therapeutic approaches Prog. Neurobiol. (IF 6.7) Pub Date : 2023-09-30 Wenying Liu, Yan Li, Tan Zhao, Min Gong, Xuechu Wang, Yue Zhang, Lingzhi Xu, Wenwen Li, Yan Li, Jianping Jia
N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple physiopathological processes, including synaptic plasticity, neuronal network activities, excitotoxic events, and cognitive impairment. Abnormalities in NMDARs can initiate a cascade of pathological events, notably in Alzheimer’s disease (AD) and even other neuropsychiatric disorders. The subunit composition of NMDARs is plastic
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A mouse model of sleep disorders in Parkinson’s disease showing distinct effects of dopamine D2-like receptor activation Prog. Neurobiol. (IF 6.7) Pub Date : 2023-10-05 Daniel de Castro Medeiros, Carina Plewnia, Renan Viana Mendes, Clarissa Anna Pisanò, Laura Boi, Marcio Flávio Dutra Moraes, Cleiton Lopes Aguiar, Gilberto Fisone
Excessive daytime sleepiness (EDS) and sleep fragmentation are often observed in Parkinson’s disease (PD) patients and are poorly understood despite their considerable impact on quality of life. We examined the ability of a neurotoxin-based mouse model of PD to reproduce these disorders and tested the potential counteracting effects of dopamine replacement therapy. Experiments were conducted in female
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Neuronal plasticity contributes to postictal death Prog. Neurobiol. (IF 6.7) Pub Date : 2023-09-29 Anastasia Brodovskaya, Huayu Sun, Nadia Adotevi, Ian C. Wenker, Keri E. Mitchell, Rachel T. Clements, Jaideep Kapur
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Dysregulation of alternative splicing underlies synaptic defects in familial Amyotrophic Lateral Sclerosis Prog. Neurobiol. (IF 6.7) Pub Date : 2023-09-20 Veronica Verdile, Ramona Palombo, Gabriele Ferrante, Alberto Ferri, Susanna Amadio, Cinzia Volonté, Maria Paola Paronetto
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles. A hallmark of ALS is the frequent nuclear loss and cytoplasmic accumulation of RNA binding proteins (RBPs) in motor neurons (MN), which leads to aberrant alternative splicing regulation. However, whether
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TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis Prog. Neurobiol. (IF 6.7) Pub Date : 2023-09-20 Peiwu Ye, Qiuyuan Fang, Xupang Hu, Wenjuan Zou, Miaodan Huang, Minjing Ke, Yunhao Li, Min Liu, Xiaobo Cai, Congyi Zhang, Ning Hua, Umar Al-Sheikh, Xingyu Liu, Peilin Yu, Peiran Jiang, Ping-Yue Pan, Jianhong Luo, Lin-Hua Jiang, Suhong Xu, Evandro F. Fang, Wei Yang
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Early top-down control of internal selection induced by retrospective cues in visual working memory: advantage of peripheral over central cues Prog. Neurobiol. (IF 6.7) Pub Date : 2023-09-04 Sizhu Han, Huihui Zhou, Yonghong Tian, Yixuan Ku
Attention can be deployed among external sensory stimuli or internal working memory (WM) representations, and recent primate studies have revealed that these external and internal selections share a common neural basis in the prefrontal cortex (PFC). However, it remains to be elucidated how PFC implements these selections, especially in humans. The present study aimed to further investigate whether
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Remote ischemic conditioning alleviates chronic cerebral hypoperfusion-induced cognitive decline and synaptic dysfunction via the miR-218a-5p/SHANK2 pathway Prog. Neurobiol. (IF 6.7) Pub Date : 2023-08-11 Ning Li, Changhong Ren, Sijie Li, Wantong Yu, Kunlin Jin, Xuming Ji
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A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome Prog. Neurobiol. (IF 6.7) Pub Date : 2023-08-01 Kara A. Lau, Xin Yang, Mengia S. Rioult-Pedotti, Stephen Tang, Mark Appleman, Jianan Zhang, Yuyang Tian, Caitlin Marino, Mudi Yao, Qin Jiang, Ayumi C. Tsuda, Yu-Wen Alvin Huang, Cong Cao, John Marshall
Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported a deficit in brain-derived neurotrophic factor (BDNF) signaling, and set out to develop a therapeutic that would restore normal signaling. We demonstrate that CN2097, a peptidomimetic compound that binds postsynaptic density protein-95
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An autonomic mode of brain activity Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-27 Ehsan Shokri-Kojori, Dardo Tomasi, Sukru B. Demiral, Gene-Jack Wang, Nora D. Volkow
The relevance of interactions between autonomic and central nervous systems remains unclear for human brain function and health, particularly when both systems are challenged under sleep deprivation (SD). We measured brain activity (with fMRI), pulse and respiratory signals, and baseline brain amyloid beta burden (with PET) in healthy participants. We found that SD relative to rested wakefulness (RW)
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The state of brain activity modulates cerebrospinal fluid transport Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-22 Leo M. Miyakoshi, Frederik F. Stæger, Qianliang Li, Chenchen Pan, Lulu Xie, Hongyi Kang, Chiara Pavan, Juliana Dang, Qian Sun, Ali Ertürk, Maiken Nedergaard
Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger
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Neurobiological mechanisms for language, symbols and concepts: Clues from brain-constrained deep neural networks Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-22 Friedemann Pulvermüller
Neural networks are successfully used to imitate and model cognitive processes. However, to provide clues about the neurobiological mechanisms enabling human cognition, these models need to mimic the structure and function of real brains. Brain-constrained networks differ from classic neural networks by implementing brain similarities at different scales, ranging from the micro- and mesoscopic levels
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Selective neuronal vulnerability to deficits in RNA processing Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-16
Emerging evidence indicates that errors in RNA processing can causally drive neurodegeneration. Given that RNA produced from expressed genes of all cell types undergoes processing (splicing, polyadenylation, 5′ capping, etc.), the particular vulnerability of neurons to deficits in RNA processing calls for careful consideration. The activity-dependent transcriptome remodeling associated with synaptic
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A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-13
Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry mechanisms remain largely unknown. Here, we found that activating but not inhibiting ventral tegmental area (VTA) DA neurons reduces mouse food intake. Furthermore, DA neurons in ventral VTA, especially neurons projecting
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Parallel neurodegenerative phenotypes in sporadic Parkinson’s disease fibroblasts and midbrain dopamine neurons Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-13 MJ Corenblum, A. McRobbie-Johnson, E. Carruth, K. Bernard, M. Luo, LJ Mandarino, S. Peterson, MA Sans-Fuentes, D. Billheimer, T. Maley, ED Eggers, L. Madhavan
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Macaque monkeys and humans sample temporal regularities in the acoustic environment Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-12 Antonio Criscuolo, Michael Schwartze, Luis Prado, Yaneri Ayala, Hugo Merchant, Sonja A. Kotz
Many animal species show comparable abilities to detect basic rhythms and produce rhythmic behavior. Yet, the capacities to process complex rhythms and synchronize rhythmic behavior appear to be species-specific: vocal learning animals can, but some primates might not. This discrepancy is of high interest as there is a putative link between rhythm processing and the development of sophisticated sensorimotor
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Uncovering and leveraging the return of voluntary motor programs after paralysis using a bi-cortical neuroprosthesis Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-05 Maude Duguay, Marco Bonizzato, Hugo Delivet-Mongrain, Nicolas Fortier-Lebel, Marina Martinez
Rehabilitative and neuroprosthetic approaches after spinal cord injury (SCI) aim to reestablish voluntary control of movement. Promoting recovery requires a mechanistic understanding of the return of volition over action, but the relationship between re-emerging cortical commands and the return of locomotion is not well established. We introduced a neuroprosthesis delivering targeted bi-cortical stimulation
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Ventrolateral prefrontal neurons of the monkey encode instructions in the ‘pragmatic’ format of the associated behavioral outcomes Prog. Neurobiol. (IF 6.7) Pub Date : 2023-07-08 Stefano Rozzi, Alfonso Gravante, Claudio Basile, Giorgio Cappellaro, Marzio Gerbella, Leonardo Fogassi
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A recruitment through coherence theory of working memory Prog. Neurobiol. (IF 6.7) Pub Date : 2023-06-29 Phillip Comeaux, Kelsey Clark, Behrad Noudoost
The interactions between prefrontal cortex and other areas during working memory have been studied for decades. Here we outline a conceptual framework describing interactions between these areas during working memory, and review evidence for key elements of this model. We specifically suggest that a top-down signal sent from prefrontal to sensory areas drives oscillations in these areas. Spike timing
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Diverse beta burst waveform motifs characterize movement-related cortical dynamics Prog. Neurobiol. (IF 6.7) Pub Date : 2023-06-28 Maciej J Szul, Sotirios Papadopoulos, Sanaz Alavizadeh, Sébastien Daligaut, Denis Schwartz, Jérémie Mattout, James J Bonaiuto
Classical analyses of induced, frequency-specific neural activity typically average band-limited power over trials. More recently, it has become widely appreciated that in individual trials, beta band activity occurs as transient bursts rather than amplitude-modulated oscillations. Most studies of beta bursts treat them as unitary, and having a stereotyped waveform. However, we show there is a wide
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Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling Prog. Neurobiol. (IF 6.7) Pub Date : 2023-06-23 Xinyue Chen, Ruiqi Gao, Yizhi Song, Tao Xu, Liangyun Jin, Wanning Zhang, Ziyan Chen, Hongqi Wang, Wenxing Wu, Suli Zhang, Guitao Zhang, Ning Zhang, Lirong Chang, Huirong Liu, Hui Li, Yan Wu
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Neutrophil biology in injuries and diseases of the central and peripheral nervous systems Prog. Neurobiol. (IF 6.7) Pub Date : 2023-06-23 Brian M. Balog, Anisha Sonti, Richard E. Zigmond
The role of inflammation in nervous system injury and disease is attracting increased attention. Much of that research has focused on microglia in the central nervous system (CNS) and macrophages in the peripheral nervous system (PNS). Much less attention has been paid to the roles played by neutrophils. Neutrophils are part of the granulocyte subtype of myeloid cells. These cells, like macrophages
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Changing connectivity between premotor and motor cortex changes inter-areal communication in the human brain Prog. Neurobiol. (IF 6.7) Pub Date : 2023-06-22 Jelena Trajkovic, Vincenzo Romei, Matthew F.S. Rushworth, Alejandra Sel
The ventral premotor cortex (PMv) is an important component of cortico-cortical pathways mediating prefrontal control over primary motor cortex (M1) function. Paired associative stimulation (ccPAS) is known to change PMv influence over M1 in humans, which manifests differently depending on the behavioural context. Here we show that these changes in influence are functionally linked to PMv-M1 phase