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3-Dimensional ultrastructural analysis of the rat pinealocyte; presence of secretory bulbous projections delineated from the cell body by junctional complexes. Neuroendocrinology (IF 4.1) Pub Date : 2023-11-29 Morten Møller,Jens Midtgaard,Klaus Qvortrup,Martin Fredensborg Rath
INTRODUCTION The superficial pineal gland of the Sprague Dawley rat is a neuroendocrine structure secreting the hormone melatonin. By use of block face scanning electron microscopy, our aim here was to identify the 3-dimensional ultrastructure of the gland. METHODS A series of 2,731 block face images of the rat pineal tissue, 30 nm in thickness, was obtained in a Teneo Video Volume scanning electron
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Electroacupuncture Alleviates Obesity and Insulin Resistance via the GLP-1-VTA DA Reward Circuit. Neuroendocrinology (IF 4.1) Pub Date : 2023-11-21 Ye Zhu,Jun Tian,Xiali Wei,Shaohui Jia,Qing Shu
OBJECTIVE We investigated the effects of electroacupuncture (EA) on improving obesity and insulin resistance (IR) in high-fat-diet-induced (HFDI) obese rats by modulating the nucleus tractus solitarius (NTS) glucagon-like peptide-1 (GLP-1)-ventral tegmental area (VTA) dopamine (DA) neural reward circuit, thereby uncovering a possible central mechanism underlying EA's actions in improving obesity and
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Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2. Neuroendocrinology (IF 4.1) Pub Date : 2023-11-04 Qing Xie,Wenyuan Zhou,Xiangxi Meng,Jin Ding,Dan Li,Ming Lu,Zhi Yang,Jiangyuan Yu
INTRODUCTION Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes, and to analyze the correlation between the image and pathology parameters. METHOD Tumor bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the
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Exposure to low doses of phthalates in male rodents: Effects on reproductive and cognitive behaviors. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-30 Suzanne Ducroq,Valerie Grange-Messent,Sakina Mhaouty-Kodja
The nervous system is a sensitive target for exposure to environmental endocrine-disrupting compounds (EDC). This vulnerability is particularly important during the critical windows of development and puberty and lasts even at later stages of life. Among these environmental EDC, phthalates have largely been described for their neurotoxic effects. These effects have been reported for a large majority
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Expression of apelin and apelin receptor protein in the hypothalamo-pituitary-ovarian axis during estrous cycle of mice. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-27 Borgohain Anima,Guruswami Gurusubramanian,Vikas Kumar Roy
INTRODUCTION Apelin is an endogenous neuropeptide expressed in the hypothalamus, pituitary and ovary; binds to apelin receptor for various functions. Hypothalamus, pituitary and ovarian axis is tightly regulated during estrous cycle. The status of apelin and its receptor has not been investigated in HPO axis during estrous cycle. METHODS To explore the expression of apelin and APJ in HPO axis of mice
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Inhibition of estradiol signaling in the basolateral amygdala impairs extinction memory recall for heroin-conditioned cues in a sex-specific manner. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-17 Jordan S Carter,Caitlyn C Costa,Angela M Kearns,Carmela M Reichel
Relapse is a major treatment barrier for opioid use disorder (OUD). Environmental cues become associated with the rewarding effects of opioids and can precipitate relapse, even after numerous unreinforced cue presentations, due to deficits in extinction memory recall (EMR). Estradiol (E2) modulates EMR of fear-related cues, but it is unknown whether E2 impacts EMR of reward cues and what brain region(s)
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Correlation of Neuroendocrine Differentiation with A Distinctively Suppressive Immune Microenvironment in Gastric Cancer. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-12 Yi Zou,Dan Li,Xiaoyan Yu,Chenqi Zhou,Chunpeng Zhu,Ying Yuan
Introduction Neuroendocrine neoplasms (NENs) harbored significantly suppressive tumor immune microenvironments (TIMEs). However, the immunological effects of neuroendocrine differentiation (NED) on non-NE neoplasms, such as gastric cancer (GC), were unknown. Methods Between pure gastric cancer (PGC) and GC-NED, TIME features were scored based on expression data and validated on serial whole-tissue
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Identifying genetic factors of polycystic ovary syndrome in women with epilepsy: a whole-genome sequencing study. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-12 Wanlin Lai,Yiming Wu,Leihao Sha,Qi Lai,Ximeng Yang,Fandi Ai,Qian Zhang,Fengxiao Bu,Shixu He,Xi Zhu,Lei Chen
INTRODUCTION Women with epilepsy (WWE) are more likely to develop reproductive endocrine disorders, especially polycystic ovary syndrome (PCOS). This study aimed to explore the genetic factors of PCOS in WWE in hope of improving individual precision diagnosis and treatment. METHODS WWE registered at West China Hospital between January 2021 and October 2021 were enrolled in this study. Demographic and
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Dual oxytocin receptor-G protein signaling in the autoregulation of activities of oxytocin neurons. Neuroendocrinology (IF 4.1) Pub Date : 2023-10-06 Xiao-Yu Liu,Shuo Ling,Yang Liu,Shuwei Jia,Xiaoran Wang,Tong Li,Dongyang Li,Chunmei Hou,Nand Lal,Hui Zhu,Yu-Feng Wang
Oxytocin (OT), a hypothalamic nonaneuropeptide, can extensively modulate mental and physical activities; however, the regulation of its secretion from hypothalamic OT neurons remains poorly understood. OT neuronal activity is generally modulated by neurochemical environment, synaptic inputs, astrocytic plasticity, and interneuronal interactions. By changing intracellular signals and ion channel activity
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Hippocampal dynamic functional connectivity, HPA axis activity, and personality trait in bipolar disorder with suicidal attempt. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-20 Shuming Zhong,Pan Chen,Shunkai Lai,Yiliang Zhang,Guanmao Chen,Jiali He,Youling Pan,Guixian Tang,Ying Wang,Yanbin Jia
Introduction Suicide in bipolar disorder (BD) is a multifaceted behavior, involving specific neuroendocrine and psychological mechanisms. According to previous studies, we hypothesized that suicidal BD patients may exhibit impaired dynamic functional connectivity (dFC) variability of hippocampal subregions and hypothalamic-pituitary-adrenal (HPA) axis activity, which may be associate with suicide-related
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Predictive factors of early FDG-PET response to [131I] MIBG treatment for unresectable or metastatic pheochromocytomas and paragangliomas (PPGLs). Neuroendocrinology (IF 4.1) Pub Date : 2023-09-19 Junki Takenaka,Shiro Watanabe,Takashige Abe,Takahiro Tsuchikawa,Satoshi Takeuchi,Kenji Hirata,Rina Kimura,Naoto Wakabayashi,Nobuo Shinohara,Kohsuke Kudo
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours that produce catecholamines. [131I] MIBG-avid unresectable or metastatic PPGLs are treated with [131I] MIBG therapy. A high metabolic tumour volume (MTV) and total lesion glycolysis (TLG) can be poor prognostic factors. Therefore, we evaluated the metabolic responses to [131I] MIBG therapy with respect to other clinical factors
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Sex Hormone-Binding Globulin and Risk of Incident Dementia in Middle-aged to older Women: Results from the UK Biobank Cohort Study. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-19 Junlin Huang,Bingyan Xu,Xiaomin Chen,Linjie Yang,Deying Liu,Jiayang Lin,Yating Liu,Xuzhen Lei,Chensihan Huang,Weijuan Dou,Dan Guo,Xueyun Wei,Peizhen Zhang,Yan Huang,Xuejiang Gu,Huijie Zhang
INTRODUCTION The association of serum sex hormone-binding globulin (SHBG) concentrations with dementia risk remains uncertain in middle-aged to older women. We examined associations of serum SHBG levels with incidence of all-cause dementia and its subtypes in middle-aged to older women from the large population-based UK Biobank cohort study. METHODS Serum total SHBG levels were measured by immunoassay
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Low Prognostic Nutritional Index is Common and Associated with Poor Outcomes Following Curative-intent Resection for Gastro-entero-pancreatic Neuroendocrine Tumors. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-13 Jun-Xi Xiang,Ye-Rong Qian,Jin He,Alexandra G Lopez-Aguiar,George Poultsides,Flavio Rocha,Sharon Weber,Ryan Fields,Kamran Idrees,Cliff Cho,Shishir K Maithel,Yi Lv,Xu-Feng Zhang,Timothy M Pawlik
INTRODUCTION To investigate the impact of prognostic nutritional index (PNI) on short- and long-term outcomes of patients who underwent curative-intent resection for gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs). METHODS Patients with GET-NETs who underwent curative-intent resection were identified from a multi-center database. The prognostic impact of clinicopathological factors including
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Clinicoradiological Factors Predicting Lymph Node Metastasis in Patients with Nonfunctioning Pancreatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-13 Boryeong Jeong,Subin Heo,Dong Wook Kim,Kyung Won Kim
INTRODUCTION Lymph node metastasis of nonfunctioning pancreatic neuroendocrine neoplasms (pNENs) potentially leads to poor survival. Given the contradictory results in the literature regarding factors associated with lymph node metastasis of nonfunctioning pNENs, we conducted a systematic review and meta-analysis to determine the preoperative predictors of lymph node metastasis. METHODS Original studies
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Functional characterization of gonadotropin-releasing hormone and corazonin signaling systems in Pacific abalone: toward reclassification of invertebrate neuropeptides. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-13 Mi Ae Kim,Tae Ha Kim,Priyadharshini Kannan,Kang Hee Kho,Keunwan Park,Young Chang Sohn
INTRODUCTION The proposed evolutionary origins and corresponding nomenclature of bilaterian gonadotropin-releasing hormone (GnRH)-related neuropeptides have changed tremendously with the aid of receptor deorphanization. However, the reclassification of the GnRH and corazonin (CRZ) signaling systems in Lophotrochozoa remains unclear. METHODS We characterized GnRH and CRZ receptors in the mollusk Pacific
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Differential G-Protein-Coupled Estrogen Receptor-1 Regulation of Counter-Regulatory Transmitter Marker and 5'-AMP-Activated Protein Kinase Expression in Ventrolateral versus Dorsomedial Ventromedial Hypothalamic Nucleus. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-12 Khaggeswar Bheemanapally,Karen P Briski
The ventromedial hypothalamic nucleus (VMN) is an estrogen receptor (ER)-rich structure that regulates glucostasis. The role of nuclear, but not membrane G-protein-coupled ER-1 (GPER) in that function has been studied. Gene silencing and laser-catapult-microdissection/immunoblot tools were used to examine whether GPER regulates transmitter and energy sensor function in dorsomedial (VMNdm) and/or ventrolateral
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DNA methylation pattern in somatotroph pituitary neuroendocrine tumors. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-12 Paulina Kober,Julia Rymuza,Szymon Baluszek,Maria Maksymowicz,Aleksandra Nyc,Beata J Mossakowska,Grzegorz Zieliński,Jacek Kunicki,Mateusz Bujko
INTRODUCTION Growth hormone secretion by sporadic somatotroph neuroendocrine pituitary tumors (PitNETs) is major cause of acromegaly. These tumors are relatively heterogenous in terms of histopathological and molecular features. Our previous transcriptomic profiling of somatotroph tumors revealed three distinct molecular subtypes. This study was aimed to investigate difference in DNA methylation pattern
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Relation between WHO classification and location- and functionality-based classifications of neuroendocrine neoplasms of the digestive tract. Neuroendocrinology (IF 4.1) Pub Date : 2023-09-08 Noah C Helderman,Manon Suerink,Gül Kilinç,José G Van Den Berg,Maartje Nielsen,Margot E T Tesselaar
Practice of neuroendocrine neoplasms (NENs) of the digestive tract, which comprise a highly diverse group of tumors with a rising incidence, faces multiple biological, diagnostic, and therapeutic issues. Part of these issues are due to misuse and misinterpretation of the classification and terminology of NENs of the digestive tract, which make it increasingly challenging to evaluate and compare literature
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Pediatric Macrocorticotropinoma: Do They Differ from Microcorticotropinoma? Neuroendocrinology (IF 4.1) Pub Date : 2023-08-25 Chethan Yamichannaiah,Saba Samad Memon,Vijaya Sarathi,Anurag Ranjan Lila,Shilpa Sankhe,Sneha Arya,Manjiri Karlekar,Virendra Ashokrao Patil,Nalini Shah,Tushar Bandgar
INTRODUCTION Cushing's disease (CD) due to macrocorticotropinoma (MC) in children and adolescents is a rare entity with limited information regarding its characteristics. The objective of the study is to describe the clinical, biochemical, imaging, management, outcome and genetic characteristics of children and adolescents with CD due to MC and compare them with those of microcorticotropinoma (mc)
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Elevated insulin levels engage the salience network during multisensory perception. Neuroendocrinology (IF 4.1) Pub Date : 2023-08-25 Katja Schumann,Rea Rodriguez-Raecke,Rik Sijben,Jessica Freiherr
INTRODUCTION Brain insulin reactivity has been reported in connection with systematic energy metabolism, enhancement in cognition, olfactory sensitivity and neuroendocrine circuits. High receptor densities exist in regions important for sensory processing. The main aim of the study was to examine whether intranasal insulin would modulate the activity of areas in charge of olfactory-visual integration
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The Regulatory Effect of the Paraventricular Nucleus on Hypertension. Neuroendocrinology (IF 4.1) Pub Date : 2023-08-19 Hanyu Xi,Xingru Li,Yun Zhou,Yaojun Sun
Hypertension is among the most harmful factors of cardiovascular and cerebrovascular diseases and poses an urgent problem for the development of human society. In addition to previous studies on its pathogenesis focusing on the peripheral sympathetic nervous system, investigating the central causes of high blood pressure involving the neuroendocrine and neuroinflammatory mechanisms of the hypothalamic
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MiR-320a acts as a tumor suppressor in somatotroph PitNETs by targeting BCAT1. Neuroendocrinology (IF 4.1) Pub Date : 2023-08-17 Sida Zhao,Bin Li,Hua Gao,Yazhuo Zhang
INTRODUCTION Aberrant miR-320a has been reported to be involved in the tumorigenesis of several cancers. In our previous study, we identified the low expression of circulating miR-320a in patients with somatotroph PitNET; however, the role of miR-320a in somatotroph PitNET proliferation is still unclear. METHODS Cell viability and colony formation assays were used to detect the effect of miR-320a and
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Role of Hormones in Substance Use Disorders. Neuroendocrinology (IF 4.1) Pub Date : 2023-08-10 Emilie F Rissman,Wendy J Lynch
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A Common Genetic Factor Underlies Genetic Risk for Gynaecological and Reproductive Disorders and Is Correlated with Risk to Depression. Neuroendocrinology (IF 4.1) Pub Date : 2023-08-04 Jacqueline Kiewa,Sally Mortlock,Samantha Meltzer-Brody,Christel Middeldorp,Naomi R Wray,Enda M Byrne
INTRODUCTION Sex steroid hormone fluctuations may underlie both reproductive disorders and sex differences in lifetime depression prevalence. Previous studies report high comorbidity among reproductive disorders and between reproductive disorders and depression. This study sought to assess the multivariate genetic architecture of reproductive disorders and their loading onto a common genetic factor
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Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus. Neuroendocrinology (IF 4.1) Pub Date : 2023-07-29 Tenna Bering,Aurea Susana Blancas-Velazquez,Martin Fredensborg Rath
INTRODUCTION In the hippocampus, clock gene expression is important for memory and mood; however, the signaling mechanism controlling clock gene expression in the hippocampus is unknown. Recent findings suggest that circadian glucocorticoid rhythms driven by the suprachiasmatic nucleus (SCN) control rhythmic clock gene expression in neurons; in addition, dexamethasone modulates hippocampal clock gene
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From Nose to Lumbar Spinal Cord - Reduced Sperm Numbers Occur by Olfactory Bulbectomy-Related Onuf's Nucleus Degeneration: New Experimental Evidence for Kallmann Syndrome. Neuroendocrinology (IF 4.1) Pub Date : 2023-07-27 Coskun Yolas,Ayhan Kanat,Mete Zeynal,Mehmet H Sahin,Mehmet K Karadag,Osman N Keles,Nezih Akca,Eyup Dil,Mehmet D Aydin,Omer Lutfi Gundogdu
INTRODUCTION Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy (OBX) causes dysfunction in spermatogenesis as a result of Onuf's nucleus damage. METHODS Twenty-eight male rats were divided
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Sex Steroid Hormone Receptor Content of Medial Preoptic Efferents to the Ventral Tegmental Area Is Sexually Dimorphic: Implications for Sex Differences in Mesolimbic Reward Processing. Neuroendocrinology (IF 4.1) Pub Date : 2023-07-10 Julia R Martz,Adriana Vasquez,Juan M Dominguez
INTRODUCTION The medial preoptic area (mPOA) is an important regulator of natural and drug-induced reward. However, despite the mPOA being implicated in sexually dimorphic reward responses, sex differences in medial preoptic efferents to the ventral tegmental area (VTA) have not been fully investigated. METHODS Two cohorts of male and female rats received unilateral injections of the tract-tracer Fluoro-Gold
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Endoscopic and Surgical Management of Non-Metastatic Ampullary Neuroendocrine Neoplasia: A Multi-Institutional Pancreas2000/EPC Study. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-27 Elias Karam,Marcus Hollenbach,Einas Abou Ali,Francesco Auriemma,Andrea Anderloni,Louise Barbier,Giulio Belfiori,Fabrice Caillol,Stefano Crippa,Marco Del Chiaro,Charles De Ponthaud,Yanis Dahel,Massimo Falconi,Marc Giovannini,Dominik Heling,Yosuke Inoue,William R Jarnagin,Galen Leung,Renato M Lupinacci,Alberto Mariani,Viliam Masaryk,Rainer Christoph Miksch,Nicolas Musquer,Bertrand Napoleon,Atsushi Oba
INTRODUCTION Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management. METHODS From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduodenal
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Endocrine Disrupting Chemicals and Hippocampal Development: The Role of Estrogen and Androgen Signalling. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-24 Diana-Ioana Lupu,Andrea Cediel Ulloa,Joëlle Rüegg
Hormones are important regulators of key processes during fetal brain development. Thus, the developing brain is vulnerable to the action of chemicals that can interfere with endocrine signals. Epidemiological studies have pointed toward sexually dimorphic associations between neurodevelopmental outcomes, such as cognitive abilities, in children and prenatal exposure to endocrine disrupting chemicals
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Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-22 Aaron L Le,Wendy J Lynch,Emilie F Rissman
INTRODUCTION Women are more vulnerable to cocaine's reinforcing effects and have a more rapid course to addiction after initial cocaine use as compared to men. Studies in rodents similarly indicate an enhanced sensitivity to the reinforcing effects of cocaine in females versus males. Levels of estradiol (E2) are correlated with vulnerability to the rewarding actions of cocaine. Here, we asked if sex
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Melatonin Attenuates Cerebral Ischemia/Reperfusion Injury through Inducing Autophagy. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-15 Umit Yilmaz,Kevser Tanbek,Semir Gul,Mehmet Gul,Ahmet Koc,Suleyman Sandal
INTRODUCTION The aim of this study was to investigate how melatonin administration for 3 days or 7 days following cerebral ischemia (CI) injury would affect autophagy and, therefore, survival in neurons of the penumbra region. Moreover, it was also aimed at determining how this melatonin treatment would affect the neurological deficit score and rotarod and adhesive removal test durations. METHODS Focal
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Isoflurane Rapidly Modifies Synaptic and Cytoskeletal Phosphoproteomes of the Supraoptic Nucleus of the Hypothalamus and the Cortex. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-02 Soledad Bárez-López,George J Gadd,Audrys G Pauža,David Murphy,Michael P Greenwood
INTRODUCTION Despite the widespread use of general anaesthetics, the mechanisms mediating their effects are still not understood. Although suppressed in most parts of the brain, neuronal activity, as measured by FOS activation, is increased in the hypothalamic supraoptic nucleus (SON) by numerous general anaesthetics, and evidence points to this brain region being involved in the induction of general
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Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle. Neuroendocrinology (IF 4.1) Pub Date : 2023-06-02 Claire M Corbett,Emily N D Miller,Erin E Wannen,Benjamin D Rood,Daniel J Chandler,Jessica A Loweth
INTRODUCTION Sex and ovarian hormones influence cocaine seeking and relapse vulnerability, but less is known regarding the cellular and synaptic mechanisms contributing to these behavioral sex differences. One factor thought to influence cue-induced seeking behavior following withdrawal is cocaine-induced changes in the spontaneous activity of pyramidal neurons in the basolateral amygdala (BLA). However
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Clinical and Proteomic-Based Molecular Characterizations of Invasive and Noninvasive Somatotroph PitNETs. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-30 Meiping Chen,Lian Duan,Wei Sun,Zhengguang Guo,Hui Miao,Na Yu,Shengmin Yang,Linjie Wang,Fengying Gong,Yong Yao,Huijuan Zhu
INTRODUCTION Somatotroph pituitary neuroendocrine tumours (PitNETs) are characterized by complex and variable biological behaviours with unpredictable patterns of growth and invasiveness. The molecular mechanisms and reliable predictors of biological markers of invasiveness remain unknown. METHODS Seventy-two acromegaly patients were consecutively enrolled. Data-independent acquisition-based proteomics
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Safety of Growth Hormone Replacement Therapy in Childhood-Onset Craniopharyngioma: A Systematic Review and Cohort Study. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-25 Jiska van Schaik,Eline Kormelink,Eda Kabak,Elvira C van Dalen,Antoinette Y N Schouten-van Meeteren,Evelien de Vos-Kerkhof,Boudewijn Bakker,Marta Fiocco,Eelco W Hoving,Wim J E Tissing,Hanneke M van Santen
INTRODUCTION Survival of childhood-onset craniopharyngioma (cCP) is excellent; however, many survivors suffer from hypothalamic-pituitary dysfunction. Growth hormone replacement therapy (GHRT) is of high importance for linear growth and metabolic outcome. Optimal timing for initiation of GHRT in cCP is on debate because of concerns regarding tumor progression or recurrence. METHODS A systematic review
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Sex Hormones, Neurosteroids, and Glutamatergic Neurotransmission: A Review of the Literature. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-20 Meredith J Goyette,Sidney L Murray,Colin J Saldanha,Kathleen Holton
Glutamatergic dysfunction has been implicated in the pathophysiology of multiple conditions including epilepsy, chronic pain, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD), raising interest in potential ways of modifying glutamate in the nervous system. Emerging research has suggested an interactive effect between sex hormones and glutamatergic neurotransmission
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Oral Oxytocin Facilitates Responses to Emotional Faces in Reward and Emotional-Processing Networks in Females. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-13 Chunmei Lan,Yuanshu Chen,Yingying Zhang,Juan Kou,Linghong Huang,Ting Xu,Xi Yang,Dan Xu,Wenxu Yang,Keith M Kendrick,Weihua Zhao
INTRODUCTION Oxytocin (OXT) is proposed as a potential therapeutic peptide for social dysfunction due to its modulatory actions on socioemotional regulation in humans. While the majority of studies have used intranasal OXT administration, we have recently shown that oral (lingual spray), but not intranasal, administration can significantly enhance activity of the brain reward system in response to
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Estrogen Receptor Beta Mediates the Dipsogenic Effect of Estradiol in Ovariectomized Female Rats. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-12 Jessica Santollo,Andrea A Edwards
INTRODUCTION Although the fluid inhibitory effects of estradiol are well characterized, a dipsogenic role of the hormone was recently identified. In ovariectomized (OVX) rats, unstimulated water intake, in the absence of food, was increased after estradiol treatment. METHODS The goals for these experiments were to further characterize the fluid enhancing effects of estradiol by determining the estrogen
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Molecular and Functional Heterogeneity of Primary Pancreatic Neuroendocrine Tumors and Metastases. Neuroendocrinology (IF 4.1) Pub Date : 2023-05-12 Yiying Guo,Chao Tian,Zixuan Cheng,Ruao Chen,Yuanliang Li,Fei Su,Yanfen Shi,Huangying Tan
INTRODUCTION Treatment response to the standard therapy is low for metastatic pancreatic neuroendocrine tumors (PanNETs) mainly due to the tumor heterogeneity. We investigated the heterogeneity between primary PanNETs and metastases to improve the precise treatment. METHODS The genomic and transcriptomic data of PanNETs were retrieved from the Genomics, Evidence, Neoplasia, Information, Exchange (GENIE)
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Alpha-melanocyte-stimulating hormone-mediated appetite regulation in the central nervous system Neuroendocrinology (IF 4.1) Pub Date : 2023-04-24 Qiwen Wu, Jingmei Chen, Tingyu Hua, Jinyan Cai
Understanding the complex action mechanism of appetite regulation peptides can significantly impact therapeutic options in the treatment of obesity and other metabolic diseases. Hypothalamic α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide, closely related to the occurrence of obesity, playing a central role in food intake and energy expenditure. In the central nervous system (CNS)
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Changes in Visual Long-term Potentiation Show Preserved Cyclicity in Human Females Taking Combined Oral Contraceptives Neuroendocrinology (IF 4.1) Pub Date : 2023-04-24 Elizabeth Stone, Malak Alshakhouri, Alexander Shaw, Suresh Muthukumaraswamy, Rachael L. Sumner
Introduction: The combined oral contraceptive pill (COC) is often employed to address physical and neurological symptoms in menstrual cycle-related disorders by suppressing shifts in endogenous gonadal hormone fluctuations. Symptom persistence, especially in the lead up to the hormone free interval (HFI) suggests an underlying neurobiological mechanism of preserved cycling. Our study utilised a non-invasive
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Prognostic Value of SSTR-derived Volumetric Parameters from a Hybrid Standardized Uptake Value Thresholding Method in Patients with 68Ga-DOTATATE-avid Stage IV Neuroendocrine Neoplasms: A preliminary study Neuroendocrinology (IF 4.1) Pub Date : 2023-04-21 Zhaoting Cheng, Sijuan Zou, Jianyuan Zhou, Shuang Song, Yuankai Zhu, Jun Zhao, Xiaohua Zhu
Introduction: The ability of PET/CT imaging to delineate neuroendocrine neoplasms (NENs) and predict prognosis in affected patients is often compromised by substantial uptake heterogeneity. We hereby proposed a hybrid standardized uptake value (SUV) thresholding algorithm to extract volumetric parameters from somatostatin receptor (SSTR) PET/CT imaging, and investigate their prognostic performance
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Variant in the dopamine-4-receptor gene (DRD4) in patients with type 1 diabetes Neuroendocrinology (IF 4.1) Pub Date : 2023-04-20 Bartosz Słomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowski
IIntroduction Because dopaminergic signaling pathways are one of the regulators of autoimmunity, we hypothesize that the -521C>T DRD4 gene polymorphism may correlate with the risk of diabetes mellitus type 1 (DM1) and its comorbidities. Methods The connection of the -521C>T DRD4 gene polymorphism with the DM1 and its comorbidities as well as the levels of serum pro- and anti-inflammatory markers, lipid
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Cortexin® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons Neuroendocrinology (IF 4.1) Pub Date : 2023-04-20 Uğur Yazar, Ahmet AYAR
Introduction: The aim of this study was to investigate whether Cortexin®, a brain peptide containing agent, has any mitigating effect on high glucose-induced neuropathy using primary cultured rat sensory neurons. Materials and Methods: Dorsal root ganglia (DRG) were excised from decapitated adult rats. Individual neurons were isolated following enzymatic and mechanical procedures. Cells were seeded
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Glucocorticoids and Water Balance: Implications for Hyponatremia Management and Pituitary Surgery Neuroendocrinology (IF 4.1) Pub Date : 2023-04-15 Mendel Castle-Kirszbaum, Tony Goldschlager, Margaret DY Shi, Peter Fuller
Water balance is fundamental to all homeostasis. The hypothalamic pituitary adrenal (HPA) axis influences water balance through the effects of corticotropin releasing hormone (CRH) and cortisol on arginine vasopressin (AVP) secretion, and the peripheral effects of cortisol on hemodynamic and renal water handling. In this review, we explore the complex interplay of glucocorticoids with water balance
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The Effects of Chronic Asprosin Administration on Sense of Smell and Sexual Behavior in Female Rats Neuroendocrinology (IF 4.1) Pub Date : 2023-04-11 Zeynep Dila Oz, Emine Kacar, Ihsan Serhatlioglu, Mehmet Ridvan Ozdede , Busra Atila, Mert Ali Horoz, Gaye Goksu Avcu, Gulendam Ozbeg, Aslisah Ozgen, Fatih Tan, Gokhan Zorlu, Abdullah Yasar, Bayram Yılmaz, Haluk Kelestimur
Introduction Asprosin is an adipokine released from white adipose tissue during fasting and acts through the olfactory receptor. It is known that adipokines play roles in reproductive physiology in mammals. However, there are very few studies conducted on role of asprosin in reproductive functions. There are no studies on its relationship with sexual motivation. It was shown in the literature that
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Sex Differences in Cocaine Sensitization Vary by Mouse Strain Neuroendocrinology (IF 4.1) Pub Date : 2023-04-11 Andrew D Chapp, Chinonso A Nwakama, Mark J Thomas, Robert L Meisel, Paul G. Mermelstein
Introduction: Preclinical literature, frequently utilizing rats, suggest females display a more rapid advancement of substance abuse and a greater risk of relapse following drug abstinence. In clinical populations, it is less clear as to what extent biological sex is a defining variable in the acquisition and maintenance of substance use. Even without considering environmental experiences, genetic
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MiRNA-383 AND MiRNA-384 SUPPRESS PROOPIOMELANOCORTIN GENE EXPRESSION IN THE HYPOTHALAMUS: EFFECTS OF EARLY LIFE ETHANOL EXPOSURE Neuroendocrinology (IF 4.1) Pub Date : 2023-03-22 Omkaram Gangisetty, Shaista Chaudhary, Prashant Tarale, Miguel Cabrera, Dipak Kumar Sarkar
Introduction: Early life ethanol exposure is known to program hypothalamic proopiomelanocortin (POMC) neurons to express a reduced level of POMC and its control of stress axis functions throughout the life span. In this study we tested whether miRNAs contribute to the ethanol-induced suppression of Pomc gene expression during the developmental period. Methods: In in vivo studies, POMC-EGFP male mice
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Second primary malignancies in patients with a neuroendocrine neoplasm in England Neuroendocrinology (IF 4.1) Pub Date : 2023-03-20 Beth Russell, Benjamin E White, Brian Rous, Kwok Wong, Catherine Bouvier Ellis, Rajaventhan Srirajaskanthan, Mieke Van Hemelrijck, John K Ramage
Introduction Patients with neuroendocrine neoplasms (NENs) may often develop other malignancies. This study aimed to identify the frequency at which these second malignancies occurred in England. Methods Data was extracted from the National Cancer Registration and Analysis Service (NCRAS) on all patients diagnosed with a NEN at one of eight NEN site groups between 2012-2018: appendix, caecum, colon
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Changes in corticotropin releasing factor receptor type 1, co-expression with tyrosine hydroxylase and oxytocin neurons, and anxiety-like behaviors across the postpartum period in mice Neuroendocrinology (IF 4.1) Pub Date : 2023-03-14 Rose M De Guzman, Zachary J Rosinger, Krystyna A Rybka, Jason S Jacobskind, Christina A Thrasher, Aya L Caballero, Kassandra L Sturm, Massoud S Sharif, Marawan S Abbas, Katherine E Parra, Kristen L Zuloaga, Nicholas J Justice, Damian G. Zuloaga
Introduction: Corticotropin-releasing factor (CRF) and its primary receptor (CRFR1) are critical regulators of behavioral and neuroendocrine stress responses. CRFR1 has also been associated with stress-related behavioral changes in postpartum mice. Our previous studies indicate dynamic changes in CRFR1 levels and coupling of CRFR1 with tyrosine hydroxylase (TH) and oxytocin (OT) neurons in postpartum
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Chromosome 18 loss of heterozygosity in small intestinal neuroendocrine tumours: Multi-omic and tumour composition analyses Neuroendocrinology (IF 4.1) Pub Date : 2023-03-10 Scott Waterfield, Paul Yousefi, Amy Webster, Caroline Relton, Chrissie Thirlwell, Matt Suderman
Background: Small intestinal neuroendocrine tumours (siNETs) are rare neoplasms which present with low mutational burden and can be subtyped based on copy number variation (CNV). Currently, siNETs can be molecularly classified as having chromosome 18 loss of heterozygosity (18LOH), multiple CNVs (MultiCNV), or no CNVs. 18LOH tumours have better progression free survival when compared to MultiCNV and
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Estradiol Enhances the Development of Addition-Like Features in a Female Rat Model of Opioid Use Disorder Neuroendocrinology (IF 4.1) Pub Date : 2023-03-06 Eleanor Blair Towers, Ben Setaro, Wendy J. Lynch
Rationale: Women are more vulnerable than men in many aspects of opioid use disorder (OUD); a major theory of sex differences in substance use disorders is that these differences are due to ovarian hormones with estradiol enhancing vulnerability in females. However, most of this evidence is for psychostimulants and alcohol; evidence with opioids is sparse. Objective: The goal of this study was to determine
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Identification of the immune subtypes for the prediction of metastasis in pancreatic neuroendocrine tumors Neuroendocrinology (IF 4.1) Pub Date : 2023-03-03 Di Meng, Lei Zhao, Jinyang Liu, Chunlin Ge, Cheng Zhang
Introduction: Most patients with pancreatic neuroendocrine tumors (pNETs) present with unresectable or metastatic disease. Increasing evidence shows that the immune cell infiltration patterns play a pivotal role in tumor progression in pNETs. Nonetheless, there has been no comprehensive analysis of the effect of immune infiltration patterns on metastasis. Methods: The gene expression profiling dataset
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Endogenous sex hormones modulate the analgesic effect of tramadol in lean and high fat diet-induced obese Wistar rats: a preclinical molecular approach Neuroendocrinology (IF 4.1) Pub Date : 2023-02-16 Shakta Mani Satyam, Laxminarayana Kurady Bairy, Prakashchandra Shetty
Introduction: Differences in pain thresholds may have implications in pain management, as they may account in part for the variability in analgesic requirements between individuals. We planned to investigate the influence of endogenous sex hormones on the analgesic modulation of tramadol in lean and high-fat diet-induced obese Wistar rats. Methods: The whole study was carried out on 48 adult Wistar
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SILIBININ, AN HSP90 INHIBITOR, ON HUMAN ACTH-SECRETING ADENOMAS Neuroendocrinology (IF 4.1) Pub Date : 2023-02-15 Francesca Pecori Giraldi, Maria Francesca Cassarino, Antonella Sesta, Giovanni Lasio, Marco Losa
Introduction. The glucocorticoid receptor is pivotal to control corticotrophin (ACTH) secretion and its function is closely linked to the heat shock protein 90 (HSP90) chaperone complex. Impaired sensitivity to glucocorticoid feedback is a hallmark of human corticotroph adenomas, i.e., Cushing’s disease, a disorder with few medical treatment options. Silibinin, a HSP90 inhibitor, has been studied in
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Author Index Vol. 113, No. 2, 2023 Neuroendocrinology (IF 4.1) Pub Date : 2023-02-10
Neuroendocrinology 2023;113:279
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Subject Index Vol. 113, No. 2, 2023 Neuroendocrinology (IF 4.1) Pub Date : 2023-02-10
Neuroendocrinology 2023;113:280
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SIN3A defects associated with syndromic congenital hypogonadotropic hypogonadism: an overlap with Witteveen-Kolk syndrome Neuroendocrinology (IF 4.1) Pub Date : 2023-02-09
Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare condition caused by GnRH deficiency. More than 40 genes have been associated with the pathogenesis of CHH, but most cases still remain without a molecular diagnosis. Mutations involving the same gene (e.g. FGFR1, PROK2/PROKR2, CHD7) were found to cause normosmic CHH and Kallmann syndrome, with and without associated phenotypes,
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5-Iodotubercidin Inhibits the Growth of Insulinoma Cells by Inducing Apoptosis Neuroendocrinology (IF 4.1) Pub Date : 2023-02-09 Biaolin Zheng, Xiubing Chen, Fengping Chen, Xiaomin Liao, Feng Wang, Zhe Yang, Nan Yi, Xiaoyan Shi, Shanyu Qin, Haixing Jiang
Background/Aims: 5-Iodotubercidin, a type of purine derivative, has attracted increasingly attention in tumor chemotherapy because of its potential as an anti-tumor agent in recent years. In this study, we confirmed the effects on apoptosis in insulinoma cell lines induced by 5-iodotubercidin and try to illuminate the underlying mechanisms. Methods: we used 5-Iodotubercidin in the treatment of insulinoma