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The Potential of Neurofilament Light as a Biomarker in Alzheimer’s Disease Eur. Neurol. (IF 1.182) Pub Date : 2021-01-21 Yong-lan Xiong; Tao Meng; Jing Luo; Hua Zhang
Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss and cognitive impairment. In 2011, the National Institute on Aging and Alzheimer’s Association (NIA-AA) Research Framework has proposed to use biomarkers to diagnose AD in living persons. AD core biomarkers show high diagnostic specificity in distinguishing AD from healthy control
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Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings Eur. Neurol. (IF 1.182) Pub Date : 2021-01-21 Pan Huang; Xiao-ying He; Min Xu
Objective: The aim is to observe the effects of argatroban injection and butylphthalide injection on blood flow rheology, clinical efficacy, and safety in patients with acute cerebral infarction. Methods: 344 patients with acute cerebral infarction within 48 h after admission were divided into treatment group and control group, with 172 cases in each group. The control group received routine treatment
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Botulinum Toxin in WW2 German and Allied Armies: Failures and Myths of Weaponization Eur. Neurol. (IF 1.182) Pub Date : 2021-01-20 Laurent Tatu; Jean-Paul Feugeas
Botulinum toxin is nowadays approved as an effective medication for various neurological disorders. The extreme toxicity of this toxin-inducing botulism, a severe lethal muscle-paralyzing illness, has been well known since the seminal works of the end of the 19th century. Because of this toxicity, botulinum toxin was one of the first agents to be considered for use as a biological weapon. The Second
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Detection of Epileptic Seizure Using Pretrained Deep Convolutional Neural Network and Transfer Learning Eur. Neurol. (IF 1.182) Pub Date : 2021-01-08 Hidir Selcuk Nogay; Hojjat Adeli
Introduction: The diagnosis of epilepsy takes a certain process, depending entirely on the attending physician. However, the human factor may cause erroneous diagnosis in the analysis of the EEG signal. In the past 2 decades, many advanced signal processing and machine learning methods have been developed for the detection of epileptic seizures. However, many of these methods require large data sets
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Association between Pre-Existing Coronary Artery Disease and 5-Year Mortality in Stroke Patients with High-Grade Carotid Artery Stenosis Eur. Neurol. (IF 1.182) Pub Date : 2020-12-23 Ching-I Wu; Chia-Lun Wu; Feng-Chieh Su; Shun-Wen Lin; Wen-Yi Huang
Background: The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of acute IS patients with high-grade CAS. Methods: From January 1, 2007, to April
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Stroke Care in the First Affiliated Hospital of Chengdu Medical College during the COVID-19 Outbreak Eur. Neurol. (IF 1.182) Pub Date : 2020-12-18 Li-Li Zhang; Yi-Jia Guo; Ya-Peng Lin; Ren-Zhong Hu; Jian-Ping Yu; Jie Yang; Xia Wang
Coronavirus disease-2019 (COVID-19) has become a pandemic disease globally. The First Affiliated Hospital of Chengdu Medical College has adopted telestroke to make stroke care accessible in remote areas. During the period January 2020 to March 2020, there was no COVID-19 case reported in our stroke center. A significant reduction of stroke admission was observed between the ischemic stroke group (235
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History of the Concept of Tuberculous Meningitis Eur. Neurol. (IF 1.182) Pub Date : 2020-12-16 Olivier Walusinski
More than a century separates the description of “dropsy of the ventricles of the brain” by Scottish physicians and Robert Koch’s identification of the causal agent of tuberculous meningitis in 1882. This article reviews the writings in Scotland and France that marked the history of the identification of this infectious entity. From John Paisley in 1734 to Robert Whytt in 1738, from Marcellin Chardel
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Exacerbation Rate in Generalized Myasthenia Gravis and Its Predictors Eur. Neurol. (IF 1.182) Pub Date : 2020-12-15 Ahmad R. Abuzinadah; Mohammed H. Alanazy; Nadeem S. Butt; Richard J. Barohn; Mazen M. Dimachkie
Objective: The aim of the study was to estimate the exacerbation incidence rate (IR) in acetylcholine receptor antibody (AChR)-positive generalized myasthenia gravis (MG) and its predictors. Methods: The primary outcome in this retrospective study was to estimate moderate-to-severe (M-S) exacerbations IR in the early course of generalized MG. The secondary outcome was to explore the predictors of MG
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Time Trends in Intracerebral Hemorrhage Associated with Oral Anticoagulation and Its Risks Factors in Spain from 2008 to 2015 Eur. Neurol. (IF 1.182) Pub Date : 2020-12-15 Sonia Quintas; Gustavo Zapata-Wainberg; Susana Arias-Rivas; Álvaro Ximénez-Carrillo; Jose Castillo; Lorena Benavente Fernández; Jaime Masjuan Vallejo; María del Mar Freijó Guerrero; José Egido; Andrés García Pastor; Pere Cardona; Aida Lago; Mar Castellanos Rodrigo; Blanca Fuentes; Mónica Sobrado; Jose Vivancos
Background: Intracerebral hemorrhage (ICH) is 7- to 10-fold higher in anticoagulated patients. Given the more extended use of oral anticoagulants, an increase in the prevalence of ICH associated with oral anticoagulation (ICH-OAC) could be expected. However, there is no previous study that assesses the time trends of ICH-OAC in Spain. Methods: We conducted a combined data analysis after creating a
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Comorbidity of Cervical Spondylogenic Myelopathy and Amyotrophic Lateral Sclerosis: When Electromyography Makes the Difference in Diagnosis Eur. Neurol. (IF 1.182) Pub Date : 2020-12-09 Maria Claudia Torrieri; Matteo Monticelli; Rosario Vasta; Fabio Cofano; Marco Ajello; Antonio Canosa; Federica Penner; Nicola Marengo; Umberto Manera; Andrea Calvo; Adriano Chiò; Diego Garbossa; Cristina Moglia
Cervical spondylogenic myelopathy (CSM) represents a common differential diagnosis for spinal onset Amyotrophic Lateral Sclerosis (ALS). Identifying occurrence of ALS in patients with CSM may be challenging. We evaluated the accuracy of Awaji criteria in the diagnosis of ALS in a cohort of patients with CSM. We screened all patients attending Turin ALS Center during the 2006–2018 period. We selected
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Treatment of Cognitive Impairment and the Role of Demographic Factors in Disease Progression: The Final Results of the Russian Observational Program “DIAMANT” Eur. Neurol. (IF 1.182) Pub Date : 2020-11-17 Vladimir Anatolyevich Parfenov; Sergey Anatolyevich Zhivolupov; Irina Evgenyevna Poverennova; Marina Valentinovna Nesterova; Svetlana Evgenyevna Ushakova; Natalia Grigoryevna Zhukova; Alexey Borisovich Glazunov; Ksenia Vladimirovna Nikulina; Mikhail Victorovich Alexandrov; Vladislav Gennadyevich Lapatukhin; Marina Grigoryevna Zhestikova
Background: Chronic cerebral ischemia (CCI) is a form of cerebrovascular disease manifested as a vascular cognitive impairment (VCI). The management of the patients with CCI is determined by a healthy lifestyle and early therapy aimed at correcting and preventing this disease. Divaza is a drug with endothelial protective and nootropic effects. We present the final efficacy and safety analysis of all-Russian
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Role of NLRP3 Inflammasomes in Neuroinflammation Diseases Eur. Neurol. (IF 1.182) Pub Date : 2020-11-17 Sen Lin; Xifan Mei
Background: Inflammasomes are large intracellular multi-protein signaling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1 and pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18
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PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis Eur. Neurol. (IF 1.182) Pub Date : 2020-11-13 Maurizio Paciaroni; Giancarlo Agnelli; Andrea Alberti; Cecilia Becattini; Francesco Guercini; Giuseppe Martini; Rossana Tassi; Giovanna Marotta; Michele Venti; Monica Acciarresi; Maria Giulia Mosconi; Simona Marcheselli; Lara Fratticci; Cataldo D’Amore; Walter Ageno; Maurizio Versino; Maria Luisa De Lodovici; Federico Carimati; Alessandro Pezzini; Alessandro Padovani; Francesco Corea; Umberto Scoditti;
Background: In this randomized trial, currently utilized standard treatments were compared with enoxaparin for the prevention of venous thromboembolism (VTE) in patients with intracerebral hemorrhage (ICH). Methods: Enoxaparin (0.4 mg daily for 10 days) was started after 72 h from the onset of ICH. The primary outcome was symptomatic or asymptomatic deep venous thrombosis as assessed by ultrasound
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Multifocal Motor Neuropathy with Persistent Conduction Block: The Seminal Case Eur. Neurol. (IF 1.182) Pub Date : 2020-11-11 François Ochsner; Laurent Tatu
Although multifocal motor neuropathy (MMN) is now recognized as a distinct, albeit rare, neurological condition, the path to its recognition was long and winding. This article provides an insight into the medical history of MMN “patient zero” and the first scientific publication that led to the recognition of MMN by the medical community. Multifocal motor neuropathy is nowadays recognized as a disease
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Charcot and His Passion for Dogs: A Historical Note Eur. Neurol. (IF 1.182) Pub Date : 2020-11-11 Fábio A. Nascimento; Carlos Henrique Ferreira Camargo; Olivier Walusinski; Hélio Afonso Ghizoni Teive
Jean-Martin Charcot, one of the most brilliant neurologists in history, was a man of few words and few gestures. He had an impenetrable and unmovable face and was described as being austere, reserved, and shy. In contrast, in his personal life, he was a softhearted man who loved animals – especially dogs. In this historical note, we sought to look into the past and learn more about Dr. Charcot’s personal
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Patients’ Experiences of Remote Neurology Consultations during the COVID-19 Pandemic Eur. Neurol. (IF 1.182) Pub Date : 2020-11-04 Mary Clare McKenna; Mahmood Al-Hinai; David Bradley; Elisabeth Doran; Isabelle Hunt; Siobhan Hutchinson; Yvonne Langan; Deirdre O’Rourke; Raga Qasem; Janice Redmond; Emma Troy; Colin P. Doherty
Telemedicine has been widely implemented during the COVID-19 global pandemic to enable continuity of care of chronic illnesses. We modified our general neurology clinic to be conducted using remote audio-only telephone consultations. We included all patients over a 10-week period who agreed to both a telephone consultation and a questionnaire afterwards in order to ascertain the patient’s perspective
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A Novel Method for Sleep-Stage Classification Based on Sonification of Sleep Electroencephalogram Signals Using Wavelet Transform and Recurrent Neural Network Eur. Neurol. (IF 1.182) Pub Date : 2020-10-29 Foad Moradi; Hiwa Mohammadi; Mohammad Rezaei; Payam Sariaslani; Nazanin Razazian; Habibolah Khazaie; Hojjat Adeli
Introduction: Visual sleep-stage scoring is a time-consuming technique that cannot extract the nonlinear characteristics of electroencephalogram (EEG). This article presents a novel method for sleep-stage differentiation based on sonification of sleep-EEG signals using wavelet transform and recurrent neural network (RNN). Methods: Two RNNs were designed and trained separately based on a database of
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Utility and Results from a Patient-Reported Online Survey in Myotonic Dystrophies Types 1 and 2 Eur. Neurol. (IF 1.182) Pub Date : 2020-10-29 Stephan Wenninger; Kristina Stahl; Federica Montagnese; Benedikt Schoser
Introduction: Myotonic dystrophies (DMs) are the most frequent autosomal dominant neuromuscular disorders in adults. Our objective was to evaluate the utility of an online survey in a rare disease as well as to assess and compare the onset and the progression of clinical symptoms in patients with myotonic dystrophy types 1 (DM1) and 2 (DM2). Methods: We conducted a patient’s reported online survey
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Predictive Value and Correlation of Neuron-Specific Enolase for Prognosis in Patients with Coma: A Systematic Review and Meta-Analysis Eur. Neurol. (IF 1.182) Pub Date : 2020-10-30 Wen Ye; Yunliang Tang; Xiaoyang Dong; Gengfa Chen; Yan Yan; Lu Zhou; Ziwen Wang; Liwei Chen; Moyi Li; Zhen Feng
Objective: Coma is the most serious disturbance of consciousness, which affects the life quality of patients and increases the burden of their family. Studies to assess the prognostic value of neuron-specific enolase (NSE) in patients with coma have not led to precise, generally accepted prognostic rules. The study aims to assess the correlation between NSE and prognosis of coma and the predictive
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Inhibition of LncRNA MALAT1 Attenuates Cerebral Ischemic Reperfusion Injury via Regulating AQP4 Expression Eur. Neurol. (IF 1.182) Pub Date : 2020-10-30 Jing Jin; Hongwei Wang; Xiaoxiao Zheng; Shangzhi Xie; Li Zheng; Renya Zhan
Stroke is one of the leading causes of mortality and disability worldwide. Long noncoding RNAs (lncRNAs) including MALAT1 have been shown to have critical roles in cerebral ischemia reperfusion injury (CIRI). However, the underlying mechanism of MALAT1 in CIRI has not been elucidated. The present study aimed to investigate the function and potential regulatory mechanism of MALAT1 in cerebral ischemic
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Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study Eur. Neurol. (IF 1.182) Pub Date : 2020-10-30 Taşkın Duman; Vildan Yayla; Derya Uludüz; Eylem Özaydın Göksu; Vedat Ali Yürekli; Hamit Genç; Uygar Utku; Nilgün Çınar; Hakan Tekeli; Mehmet Ali Sungur; Firdevs Ezgi Tokuç; Nevzat Uzuner; Mehmet Güney Şenol; Arda Yılmaz; Mustafa Gökçe; Seden Demirci; Özge Yılmaz Küsbeci; Gülnur Tekgöl Uzuner; Şevki Şahin; Hale Zeynep Batur Çağlayan; Mustafa Açıkgöz; Fatih Özdağ; Sevim Baybaş; Hakan Ekmekçi; Murat Çabalar;
Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical
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Cerebral Hyperperfusion Syndrome and Related Conditions Eur. Neurol. (IF 1.182) Pub Date : 2020-10-16 Montserrat González Delgado; Julien Bogousslavsky
Cerebral vasoconstriction is a normal physiological response under determined conditions to preserve a normal cerebral blood flow. However, there are several syndromes, with impaired cerebral autoregulation and cerebral vasoconstriction, not related with infection or inflammation, which share the same radiological and clinical presentation. We review here the cerebral hyperperfusion syndrome and related
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Erratum Eur. Neurol. (IF 1.182) Pub Date : 2020-10-12 J. Bogousslavsky; Julien Bogousslavsky; Claudio L. Bassetti; Jean-Marc Burgunder; Massimo Filippi; Eduardo Nobile-Orazio; Olivier W. Walusinski; Arne May; Matthew N. Meriggioli; Oscar L. Lopez; Russell David; Peter J. Koehler; Reiner Benecke; Francesco Graus; Kazumi Kimura; Andreas J. Steck; Selim R. Benbadis; N. Sindic; Laurent Tatu; Wolfgang H. Oertel; Alexis Brice; Karl Lovblad; Karl Olof Lövblad;
Eur Neurol
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Dissociative Language Representation in a Patient with Schizencephaly Eur. Neurol. (IF 1.182) Pub Date : 2020-10-08 Miseon Kwon; Woo Hyun Shim; Mi Jung Kim; Sang-Joon Kim; Jae-Hong Lee
Eur Neurol
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Validation of the Simplified Modified Rankin Scale Questionnaire Eur. Neurol. (IF 1.182) Pub Date : 2020-10-07 Eva Isaksson; Per Wester; Ann Charlotte Laska; Per Näsman; Erik Lundström
Introduction: The modified Rankin scale (mRS) is the most common assessment tool for measuring overall functional outcome in stroke studies. The traditional way of using mRS face-to-face is time- and cost-consuming. The aim of this study was to test the validity of the Swedish translation of the simplified modified Rankin scale questionnaire (smRSq) as compared with the mRS assessed face-to-face 6
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John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis Eur. Neurol. (IF 1.182) Pub Date : 2020-10-07 Katarzyna Kapica-Topczewska; Francois Collin; Joanna Tarasiuk; Agata Czarnowska; Monika Chorąży; Anna Mirończuk; Jan Kochanowicz; Alina Kułakowska
Introduction: Presence of anti-JC-virus antibodies (JCVAbs) is associated with the increased risk of natalizumab (NAT)-related progressive multifocal leukoencephalopathy (PML). Little is known about seroconversion rate and time to seroconversion in relapsing-remitting multiple sclerosis (RRMS) patients treated with NAT in Poland. The aim of the study was to assess the true risk of PML, seroconversion
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The Genetics Analysis of Molecular Pathogenesis for Alzheimer's Disease Eur. Neurol. (IF 1.182) Pub Date : 2020-10-07 Guanchuan Lin; Kaiyuan Ji; Shiyu Li; Wenli Ma; Xinghua Pan
Introduction: The molecular pathogenesis of Alzheimer’s disease (AD) is still not clear, and the relationship between gene expression profile for different brain regions has not been studied. Objective: Bioinformatic analysis at the genetic level has become the best way for the pathogenesis research of AD, which can analyze the abovementioned relationship. Methods: In this study, the datasets of AD
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“Stat Rosa Pristina Nomine, Nomina Nuda Tenemus”: The Many Syndromes, Diseases, and Anatomic Structures Bearing Jean-Martin Charcot’s Name Eur. Neurol. (IF 1.182) Pub Date : 2020-10-05 Matheus Kahakura Franco Pedro; Thiago Ferreira Simões De Souza
The sheer magnitude of Jean-Martin Charcot’s contributions to neurology, pathology, psychiatry, and internal medicine has allowed for the common usage of eponyms bearing the master’s name in recognition of his work. However, these are so numerous that confusion has naturally arisen concerning the exact nature of each eponym, allowing for different specialists to refer to completely different ailments
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Effectiveness, Safety, and Health-Related Quality of Life of Chronic Migraine Patients Treated with Onabotulinum Toxin A. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-23 Yesim Beckmann,Fatma Çetin Üncü,Tülay Kurt İncesu,Sabiha Türe
Objective: The present study aims to describe the efficacy and safety of onabotulinum toxin A (BonT-A) with evaluation of treatment satisfaction and impact on quality of life in chronic migraine (CM) patients in real life. Methods: This study was conducted in CM patients who were treated with BoNT-A with 12 months of follow-up. Data about outcome, adverse events, and patients’ pre- and post-treatment
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Axonal Degeneration Independent of Inflammatory Activity: Is It More Intense in the Early Stages of Relapsing-Remitting Multiple Sclerosis Disease? Eur. Neurol. (IF 1.182) Pub Date : 2020-09-21 Vedat Cilingir,Muhammed Batur
Background: This study aimed to investigate whether there are differences in the axonal degeneration rate between patients in the early years of relapsing-remitting multiple sclerosis (RRMS) disease and RRMS patients in their later years. Methods: The early-stage RRMS patients (EMS) group had 65 patients whose duration of disease was within 3 years from the date of the first attack. The late-stage
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Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-17 Oscar H Del Brutto,Robertino M Mera,Aldo F Costa,Patricia Silva,Victor J Del Brutto
Dawson fingers are used to differentiate multiple sclerosis (MS) from other conditions that affect the subcortical white matter. However, there are no studies evaluating the presence of Dawson fingers in subjects with cerebral small vessel disease (cSVD). We aimed to assess prevalence and correlates of Dawson fingers in older adults with cSVD-related moderate-to-severe white matter hyperintensities
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Therapeutic and Immunoregulatory Effects of Tacrolimus in Patients with Refractory Generalized Myasthenia Gravis. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-15 Hui Wu,Zhangyang Wang,Jianying Xi,Jue Liu,Chong Yan,Jie Song,Liang Wang,Sisi Jing,Yan Wang,Chongbo Zhao
Objectives: The aim of this study wasto investigate the efficacy of tacrolimus treatment in patients with refractory generalized myasthenia gravis (MG) and explore its impact on lymphocytic phenotypes and related cytokines mRNA expression. Methods: A total of 24 refractory generalized MG patients were enrolled. Before treatment and at 2, 6, and 12 months after tacrolimus treatment, the therapeutic
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The Merging Tracks of Anosognosia and Neglect. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-14 Karen G Langer,Julien Bogousslavsky
Anosognosia and hemineglect are among the most startling neurological phenomena identified during the 20th century. Though both are associated with right hemisphere cerebral dysfunction, notably stroke, each disorder had its own distinct literature. Anosognosia, as coined by Babinski in 1914, describes patients who seem to have no idea of their paralysis, despite general cognitive preservation. Certain
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Age and Diastolic Blood Pressure Play an Important Role in the Progression of White Matter Lesions: A Meta-Analysis. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-09 Dong Zhang,Yi Tang,Jian Ge,Yumeng Liu,Jing Jin,Mingli He
Introduction: White matter lesions (WMLs) are currently considered as a cerebral microvascular disease, and hypertension is considered as its most important risk factor. This study analysis systematically evaluated the effects of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the progression of WMLs. Methods: We searched the MeSH terms: “white matter,” “blood pressure,” “hypertension
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Uncovering the Potential Differentially Expressed miRNAs and mRNAs in Ischemic Stroke Based on Integrated Analysis in the Gene Expression Omnibus Database. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-09 Xiaotun Zhu,Xiao Liu,Ying Liu,Wansheng Chang,Yanfeng Song,Shulai Zhu
Introduction: Ischemic stroke is the third leading cause of death. There is no known treatment or cure for the disease. Moreover, the pathological mechanism of ischemic stroke remains unclear. Objective: We aimed to identify potential microRNAs (miRNAs) and mRNAs, contributing to understanding the pathology of ischemic stroke. Methods: First, the data of miRNA and mRNA were downloaded for differential
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Cerebral Venous Thrombosis: A Comprehensive Review. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-02 Pretty Sara Idiculla,Dhineshreddy Gurala,Manikandan Palanisamy,Rajendran Vijayakumar,Sindhu Dhandapani,Elanagan Nagarajan
Background: Cerebral sinus venous thrombosis (CSVT) is a relatively rare, potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. A literature search on PubMed using the keyword “Cerebral sinus venous thrombosis” was performed. We searched for the epidemiology, risk factors, pathophysiology, clinical features
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Myelography and the 20th Century Localization of Spinal Cord Lesions. Eur. Neurol. (IF 1.182) Pub Date : 2020-09-01 Bart Lutters,Rob J M Groen,Peter J Koehler
In this article, we commemorate the centenary of myelography, a neuroradiological procedure that, despite certain disadvantages, significantly contributed to the diagnosis and localization of spinal cord lesions during the 20th century. From the start, the use of myelography was characterized by different views regarding the potential dangers associated with the prolonged exposure of a “foreign body”
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Classical Clinical and Neuroimaging Findings in SMART (Stroke-Like Migraine Attacks after Radiation Therapy) Syndrome. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-31 Flávia Sprenger,Lucas Daniel Carstens,Bernardo Corrêa de Almeida Teixeira
Eur Neurol
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Worth Their Salt: One Hundred Years of Hyperosmolar Therapy. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-31 Bart Lutters,Peter J Koehler,Eelco F Wijdicks
In this article, we commemorate the centenary of the discovery and clinical implementation of hyperosmolar therapy for the treatment of increased intracranial pressure (ICP). Following the pioneering work of anatomists Weed and McKibben in 1919, the use of hypertonic solutions was soon adopted into clinical practice, even though the preferred hypertonic agent, route of administration, and ideas regarding
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Progressive Multiple Sclerosis Transcriptome Deconvolution Indicates Increased M2 Macrophages in Inactive Lesions. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-28 Sai Batchu
Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The present study aimed to quantify the relative abundances of M2 macrophages in different lesion types excised from human MS patients. CIBERSORTx, an established
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HyperCKemia in Guillain-Barré Syndrome. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-12 Seok-Jin Choi,Yoon-Ho Hong,Jun-Soon Kim,Je-Young Shin,Jung-Joon Sung
The aim of the present study was to investigate the frequency and clinical features of Guillain-Barré syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (n = 19), acute bulbar palsy (n = 3), and those whose serum creatine kinase (CK) levels were not measured (n = 45). Twelve of
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Egocentric and Allocentric Spatial Cognition in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-12 Ritsuo Hashimoto,Momoko Uechi,Noriyo Komori
Background: Topographical disorientation is one of the early symptoms of Alzheimer’s disease (AD). The nature of this symptom, however, remains unclear. Objective: The aim of the study was to investigate egocentric and allocentric spatial cognition in patients with amnestic mild cognitive impairment (aMCI) and early AD. Participants and Methods: The participants consisted of normal healthy volunteers
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Accelerated MR Evaluation of Patients with Suspected Large Arterial Vessel Occlusion: Diagnostic Performances of the FLAIR Vessel Hyperintensities. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-12 Romain Bourcier,Romain Thiaudière,Laurence Legrand,Benjamin Daumas-Duport,Hubert Desal,Grégoire Boulouis
Background: Fluid attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) document slowed vascular flow at the level and after the occlusion site patients with acute ischemic stroke (AIS). We aimed to assess the accuracy of FVH for the confirmation and location of a large vessel occlusion (LVO). Methods: Three radiologists reviewed the FLAIR sequence of the admission MRI exam of patients
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Feasibility of a Cognitive Training Game in Parkinson's Disease: The Randomized Parkin'Play Study. Eur. Neurol. (IF 1.182) Pub Date : 2020-08-05 Sjors C F van de Weijer,Annelien A Duits,Bastiaan R Bloem,Nienke M de Vries,Roy P C Kessels,Sebastian Köhler,Gerrit Tissingh,Mark L Kuijf
Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson’s disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to
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Babinski, Bektherev, Cerletti, Head, and Hitzig: European Neurologists Nominated for the Nobel Prize 1901-1950. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-30 Nils Hansson,Lotte Palmen,Giacomo Padrini,Axel Karenberg
Introduction: This article provides for the first time an overview of the most often nominated European neurologists for the Nobel Prize, who never received the award. It sheds light on candidates from France, Germany, Italy, Russia, and the UK during the first half of the 20th century. The aim is to highlight the candidates in the field of neurology, to discuss key arguments in the nomination letters
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Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-30 Pretty Sara Idiculla,Dhineshreddy Gurala,Jobin Philipose,Kartikeya Rajdev,Prateek Patibandla
Background: Cerebral cavernous malformations (CCMs) are intracranial vascular malformations that can exist as a single lesion or mixed vascular lesions. The most common mixed form is the coexistence of CCM with an associated developmental venous anomaly (DVA). In this paper, we aim to give a comprehensive review of CCM, DVA, and their coexistence as mixed lesions. A PubMed search using the keywords
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Headache and Osmophobia in Gas Station Workers Exposed to Gasoline Odor. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-28 Patrick Mesquita Sousa-Santos,Cássy Geovanna Ferreira Moura,Jean Lima Fontenele,Natalya de Carvalho Lima,Ravenna Araújo Santos,Raimundo Pereira Silva-Néto
Introduction: Headache attacks may be triggered by several factors, among them odors, especially in migraine patients. Objectives: The aim of this study wasto determine the association between gasoline odor and headache attacks in patients with migraine or tension-type headache (TTH). Subjects and Methods: The study was prospective, cross-sectional, with comparison of groups, using nonrandom sample
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Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-28 Radka Bužgová,Radka Kozáková,Monika Škutová
Background: Only a few studies have been done focusing on the quality of life (QoL) of patients with multiple sclerosis (MS) as well as their family members. The aim of our research was to determine the factors that influence the QoL of MS patients in advanced stage of disease and their caregivers. Methods: The sample of the cross-sectional study included 153 patients with MS and 74 caregivers. QoL
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Ceasing Antiquated Conceptions: A Telling of the Early and Evolving History of Epilepsy. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-27 Nadia Khalil,Selim Benbadis,Derrick Robertson
The word epilepsy is derived from the Greek word epilambanein, meaning “to seize.” This term came to embody the disease as early descriptions characterized seizures as events in which the faculties of the mind and body were “seized” from the individual. This notion of seizing the mind and body’s faculties has in essence remained a constant throughout the evolution of epilepsy. The theories elucidating
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Evaluation of Clinical Features and Stroke Etiology in Patients with Bilateral Middle Cerebellar Peduncle Infarction. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-24 Chenguang Zhou,Haixia Fan,Hao Chen,Haoyue Wang,Zuopeng Li,Ning Xu,Ruonan Sun,Yinghui Zhu,Yuanhong He
Objective: The aim of this study was to characterize clinical features, etiologies, and mechanisms of strokes due to bilateral middle cerebellar peduncle infarction (BMCPI). Methods: Cases diagnosed as BMCPI in our hospital were retrieved, and a literature review was performed. Data on clinical features and brain MRI were obtained. Extracranial and intracranial segments of the vertebrobasilar artery
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Mild Encephalitis/Encephalopathy with a Reversible Isolated Splenial Lesion (MERS) in Adult Patients: A Small Case Series. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-22 Zhen Zhang,Jing Guo,Xiaobin Li,Chuanling Li,Xiaolin Ma,Xiao Cui
Background: Mild encephalitis/encephalopathy with a reversible isolated splenial lesion (MERS) is a rare and complex clinico-radiological condition that aggregates various diseases. From a geographical point of view, most cases have been reported in Asia, especially in Japan. However, a very limited number of studies have properly evaluated Chinese patients diagnosed with MERS. Methods: Putative e
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Loss of GFAP and Vimentin Does Not Affect Peri-Infarct Depolarizations after Focal Cerebral Ischemia. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-21 Zelong Zheng,Xuxia Yi,Jianping Lv
Peri-infarct depolarization (PID), one kind of spreading depolarization, contributes to infarct volume enlargement after ischemic stroke. Astrocytes participate in PIDs by various mechanisms. The roles of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins in astrocytes, however, in PIDs induction and propagation remain unknown. Middle cerebral artery occlusion
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Conversion of Optic Neuritis to Relapsing Remitting Multiple Sclerosis: A Retrospective Comorbidity Cohort Study. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-20 Mesrure Koseoglu,Mesude Tutuncu
Objective: The aim of the study was to determine the risk of multiple sclerosis (MS) conversion after optic neuritis (ON) and to identify the predictive factors on conversion in Turkish patients. Methods: Patients whose first clinical attacks had been ON were included in the study. The primary end point was the diagnosis of clinical relapse-remitting MS. Result: Except for the bilateral involvement
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The Duels of Pierre Marie and Jules Dejerine. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-20 Hélio Teive,Matheus Gomes Ferreira,Carlos Henrique Ferreira Camargo,Renato Puppi Munhoz,Olivier Walusinski
In no country has the duel prevailed to such a great extent as in France where the matter of dueling and affairs of honor were of frequent occurrence until the 20th century. The term duel has since been established for any contest between 2 persons or parties, be they sporting, intellectual, political, or in other matters. Despite their worldwide recognition and great scientific production, Pierre
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Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-20 Panpan Yao,Liping Zhou,Lujie Zhu,Binjie Zhou,Qin Yu
Neurodegenerative disease is a kind of chronic, progressive nervous system disease characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the development of the disease. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSCs). MSCs are pluripotent stem cells with capacities for self-renewal and multidirectional differentiation
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Time Is Brain: A Call to Action to Support Stroke Centers in Low- and Middle-Income Countries during the COVID-19 Pandemic. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-15 Afshin Borhani-Haghighi,Reza Bavarsad Shahripour,Mahmoud Reza Azarpazhooh
Eur Neurol
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Lyme Neuroborreliosis with Long Meningeal Enhancement and Ischemic Stroke. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-15 Payam Dibaj,Margret Schnegelsberg,Renate Kröger
Eur Neurol
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Urodynamic Assessment of Neuronal Intranuclear Inclusion Disease. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-09 Yosuke Aiba,Ryuji Sakakibara,Fang-Ching Lee,Fuyuki Tateno
Neuronal intranuclear inclusion disease (NIID) is a disease that causes leukoencephalopathy (dementia) and peripheral neuropathy (variable manifestation including bladder dysfunction). This is the first urodynamic report to show that bladder dysfunction in NIID is a combination of detrusor overactivity, decreased bladder sensation, large post-void residual, and neurogenic changes in the sphincter electromyogram
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What Are the Minimal Detectable Changes in SDMT and Verbal Fluency Tests for Assessing Changes in Cognitive Performance in Persons with Multiple Sclerosis and Non-Multiple Sclerosis Controls? Eur. Neurol. (IF 1.182) Pub Date : 2020-07-07 Eloi Magnin,Yoshimasa Sagawa,Thierry Moulin,Pierre Decavel
Introduction: Cognitive impairment is frequent in persons with multiple sclerosis (PwMS) and can impact on activities of daily living. The capacity to differentiate real changes from background statistical noise induced by human, instrumentational, and environmental variations inherent to the evaluation would improve cognitive assessments. Objective: To assess the short-term reproducibility of cognitive
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RBM5 Acts as Tumor Suppressor in Medulloblastoma through Regulating Wnt/β-Catenin Signaling. Eur. Neurol. (IF 1.182) Pub Date : 2020-07-01 Jianzhong Yu,Guangchun Ji,Wei Shi,Rui Zhao,Wenjun Shen,Jicui Zheng,Hao Li,Fei Jiang
Introduction: RBM5 acts as a tumor suppressor gene in lung and breast cancers; however, its role in the pathogenesis of medulloblastoma (MB) remains unclear. We previously identified 4 RBM5 mutations in whole exome sequencing analysis of 40 MB patients. This study examined the role of RBM5 in MB progression. Methods: The expression patterns of RBM5 in tissues of 40 MB patients were analyzed using