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Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-16 Harkomal Verma, Sharanjot Kaur, Sukhchain Kaur, Prabhakar Gangwar, Monisha Dhiman, Anil Kumar Mantha
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Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-15 Bei Jing, Zhen-ni Chen, Wai-mei Si, Jia-ji Zhao, Guo-ping Zhao, Di Zhang
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TrkB-BDNF Signalling and Arc/Arg3.1 Immediate Early Genes in the Anterior Cingulate Cortex and Hippocampus: Insights into Novel Memory Milestones Through Behavioural Tagging Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-15 Mehar Naseem, Hiba Khan, Suhel Parvez
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Influenza A Virus PB1-F2 Induces Affective Disorder by Interfering Synaptic Plasticity in Hippocampal Dentate Gyrus Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-15 Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yang
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Compositional Features and Codon Usage Pattern of Genes Associated with Parkinson’s Disease Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-15 Arif Uddin
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Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-14 Shaojun Wu, Jie Miao, Susu Zhu, Xinyuan Wu, Jindan Shi, Jichao Zhou, Yi Xing, Kun Hu, Jie Ren, Hao Yang
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Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-14 Xin Cheng, Yejun Tan, Hongli Li, Zhen Zhang, Shan Hui, Zheyu Zhang, Weijun Peng
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A Novel Peptide Driving Neurodegeneration Appears Exclusively Linked to the α7 Nicotinic Acetylcholine Receptor Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-14 Sanskar Ranglani, Sibah Hasan, Joanna Komorowska, Nathalia Mayag Medina, Kashif Mahfooz, Anna Ashton, Sara Garcia-Ratés, Susan Greenfield
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Antitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-14 Natália Pontes Bona, Nathalia Stark Pedra, Luiza Spohr, Francieli da Silva dos Santos, Juliane Torchelsen Saraiva, Fabiano Barbosa Carvalho, Marilda da Cruz Fernandes, Ana Sofia Fernandes, Nuno Saraiva, Marta Filipa Martins, Rejane Giacomelli Tavares, Roselia Maria Spanevello, Mayara Sandrielly Soares de Aguiar, Francieli Moro Stefanello
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BMSC-Derived Exosomes Carrying miR-26a-5p Ameliorate Spinal Cord Injury via Negatively Regulating EZH2 and Activating the BDNF-TrkB-CREB Signaling Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-13 Min Chen, Yu Lin, Wenbin Guo, Lihui Chen
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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-13
Abstract Previous studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS), including rs17824933 in the CD6 gene, rs1883832 in the CD40 gene, rs2300747 in the CD58 gene, rs763361 in the CD226 gene, rs16944 in the IL-1β gene, rs2243250 in the IL-4 gene, and rs12722489 and rs2104286 in the IL-2Rα gene. However, the results remained
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High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-13
Abstract HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein superfamilies that make up the HMG (high mobility group) protein group. HMGB1 is involved in a variety of physiological and pathological processes in the human body, including a structural role in the cell nucleus as well as replication, repair, DNA transcription, and assembly of nuclear proteins. It functions
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The Role of Dietary Peptides Gluten and Casein in the Development of Autism Spectrum Disorder: Biochemical Perspectives Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-12 Geir Bjørklund, Nagwa A Meguid, Maha Hemimi, Elen Sahakyan, Katarine Fereshetyan, Konstantin Yenkoyan
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Chronic Pain–Related Cognitive Deficits: Preclinical Insights into Molecular, Cellular, and Circuit Mechanisms Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-12 Siyi Han, Jie Wang, Wen Zhang, Xuebi Tian
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Involvement of Calpain in Neurovascular Unit Damage through Up-regulating PARP-NF-κB Signaling during Experimental Ischemic Stroke Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-12
Abstract Calpain and PARP-NF-κB signaling are reported to participate in the ischemic brain injury. In this study, it was investigated whether calpain was contributed to the neurovascular unit (NVU) damage through up-regulating PARP-NF-κB signaling during experimental ischemic stroke. Male Sprague-Dawley rats were suffered from 90 min of middle cerebral artery occlusion, followed by reperfusion. The
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The Interplay of Mitochondrial Bioenergetics and Dopamine Agonists as an Effective Disease-Modifying Therapy for Parkinson’s Disease Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-11 Neha, Iqra Mazahir, Sara Akhtar Khan, Pooja Kaushik, Suhel Parvez
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Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-09 Yiyuan Zhang, Chunyun Luo, Puxin Huang, Yahong Cheng, Yufang Ma, Jiefang Gao, Hong Ding
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TXNIP Regulates NLRP3 Inflammasome-Induced Pyroptosis Related to Aging via cAMP/PKA and PI3K/Akt Signaling Pathways Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-09 Xiaoshuang Xi, Rong Zhang, Yijia Chi, Ziman Zhu, Ruifeng Sun, Weijun Gong
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Plasmalogens and Octanoylcarnitine Serve as Early Warnings for Central Retinal Artery Occlusion Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-08
Abstract Central retinal artery occlusion (CRAO) is a kind of ophthalmic emergency which may cause loss of functional visual acuity. However, the limited treatment options emphasize the significance of early disease prevention. Metabolomics has the potential to be a powerful tool for early identification of individuals at risk of CRAO. The aim of the study was to identify potential biomarkers for CRAO
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m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-08 Xin Ren, Zhuxiao Feng, Xiaodong Ma, Lijuan Huo, Huiying Zhou, Ayu Bai, Shujie Feng, Ying Zhou, Xuchu Weng, Changhe Fan
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Inulae Flos has Anti-Depressive Effects by Suppressing Neuroinflammation and Recovering Dysfunction of HPA-axis Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-08 Jin Se Kim, Jin Hee Kim, Hyeyoon Eo, In Gyoung Ju, So-ri Son, Ji-Woon Kim, Dae Sik Jang, Myung Sook Oh
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Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-07 Yan-Lin Ren, Zheng Jiang, Jia-Yi Wang, Qin He, Si-Xu Li, Xiao-Jing Gu, Yang-Ran Qi, Min Zhang, Wen-Jie Yang, Bei Cao, Jing-Yu Li, Yi Wang, Yong-Ping Chen
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Interferon Regulatory Factor 5 Gene Polymorphisms and mRNA Expression Levels Are Associated with Neuromyelitis Optica Spectrum Disorder Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-07 Gaoning Wang, Liu Jing, Ying Wang, Arshad Mehmood, Huining Zhang, Ruoyi Guo, Lu Zhang, Bin Li
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Andrographolide Improves ApoE4-Mediated Blood–Brain Barrier Injury by Alleviating Inflammation Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-06 Xuebin Zhou, Jinhua Li, Shengli Quan, Xinyue Zhang, Lili Gu, Min Hu, Wenhai Huang, Qin Li
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Selective Medial Septum Lesions in Healthy Rats Induce Longitudinal Changes in Microstructure of Limbic Regions, Behavioral Alterations, and Increased Susceptibility to Status Epilepticus Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-05 Hiram Luna-Munguia, Deisy Gasca-Martinez, Alejandra Garay-Cortes, Daniela Coutiño, Mirelta Regalado, Ericka de los Rios, Paulina Villaseñor, Fernando Hidalgo-Flores, Karen Flores-Guapo, Brandon Yair Benito, Luis Concha
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Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-05
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Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-05
Abstract The aim of this study is to explore paroxetine’s effect on nerve growth factor (NGF), human neurotrophin-4 (NT-4), and brain-derived neurotrophic factor (BDNF) levels in post-stroke depression. Ninety-two post-stroke depression patients from April 2021 to April 2023 in our hospital were selected and numbered 1 to 92 after enrollment. Forty-six patients with odd number and 46 patients with
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Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-05 Ting Zheng, Taotao Jiang, Hongxiang Ma, Yanping Zhu, Manxia Wang
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SOX9 Promotes Collagen VI Secretion by Upregulating PCOLCE in Neurofibroma Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-04 Xuan Yao, Bo Wang, Yuanping Su, Zhitong Bing, Qiao Li, Qiang Dong, Hang Yin, Jianying Wang, Yawen Pan, Guoqiang Yuan
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Comprehensive Insight into the Functional Roles of NK and NKT Cells in HTLV-1-Associated Diseases and Asymptomatic Carriers Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-04 Maryam Mahdifar, Reza Boostani, Graham P. Taylor, Seyed Abdolrahim Rezaee, Houshang Rafatpanah
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M2 Microglia-Derived Exosomes Protect Against Glutamate-Induced HT22 Cell Injury via Exosomal miR-124-3p Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-04 Lan Zhu, Limei Ma, Xin Du, Yuhao Jiang, Jiake Gao, Zihao Fan, Hengheng Zheng, Jianjun Zhu, Gaofeng Zhang
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Arginine Methylation of β-Catenin Induced by PRMT2 Aggravates LPS-Induced Cognitive Dysfunction and Depression-Like Behaviors by Promoting Ferroptosis Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Lei Mao, Jiyue You, Min Xie, Yunxia Hu, Qin Zhou
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The Protective Effects of Syringic Acid on Bisphenol A–Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Bizhan Helli, Seyedeh Parisa Navabi, Seyed Ahmad Hosseini, Ali Sabahi, Layasadat Khorsandi, Nasrin Amirrajab, Masoud Mahdavinia, Sohrab Rahmani, Mohammad Amin Dehghani
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The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)—Implications for Parkinson’s Disease and Rett Syndrome Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Ina Schmitt, Bernd O. Evert, Amit Sharma, Hassan Khazneh, Chris Murgatroyd, Ullrich Wüllner
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Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Irena Majkutewicz, Ewelina Kurowska-Rucińska, Jan Ruciński, Dorota Myślińska, Beata Grembecka, Jagoda Mantej, Katarzyna P. Dzik
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Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer’s Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevello
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Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-02 Andrey Y. Vinokurov, Alexander A. Palalov, Kristina A. Kritskaya, Svetlana V. Demyanenko, David G. Garbuz, Michael B. Evgen’ev, Noemi Esteras, Andrey Y. Abramov
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Protective Effects of Plant-Derived Compounds Against Traumatic Brain Injury Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Maryam Khanahmadi, Amirreza Samanian, Saeideh Momtaz, Vasily N. Sukhorukov, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, George E. Barreto, Amirhossein Sahebkar
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The Role of Nicotine Metabolic Rate on Nicotine Dependence and Rewarding: Nicotine Metabolism in Chinese Male Smokers and Male Mice Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Mingda Liu, Hongjuan Wang, Yaning Fu, Xiangyu Li, Ping Wu, Guanglin Liu, Ruiyan Wang, Yuan Zhang, Huan Chen, Hongwei Hou, Qingyuan Hu
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Single-Cell RNA Sequencing Transcriptomics Revealed HCMV IE2-Related Microglia Responses in Alzheimer’s-Like Disease in Transgenic Mice Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Fengjun Liu, Zhifei Wang, Delei Niu, Xianjuan Zhang, Fulong Nan, Shasha Jiang, Jun Li, Meng Yu, Xiaoli Yang, Shuyun Zhang, Xiaoqiong Zhou, Hui Wang, Xueming Zhang, Wenxuan Liu, Zonghui Li, Yunyang Wang, Bin Wang
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A New Approach for Exploring Reperfusion Brain Damage in Hypoxic Ischemic Encephalopathy Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Tianlei Zhang, Zhiwei Zhang, Jiayi Geng, Kexin Lin, Xinru Lin, Mengdie Jiao, Jianghu Zhu, Xiaoling Guo, Zhenlang Lin
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MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Yu Zhan, Yong Wen, Fan Zheng, Li-juan Du, Tai-yu Chen, Xu-long Shen, Rong Wu, Xue-gui Tang
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Inflammation and Brain Structure in Alzheimer’s Disease and Other Neurodegenerative Disorders: a Mendelian Randomization Study Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
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FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01 Lisha Wang, Jakub Wojcieszak, Rajnish Kumar, Zhe Zhao, Xuelian Sun, Shaoxun Xie, Bengt Winblad, Pavel F. Pavlov
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Serum Uric Acid Levels and Outcome of Acute Ischemic Stroke: a Dose–Response Meta-analysis Mol. Neurobiol. (IF 5.1) Pub Date : 2024-03-01
Abstract Previous meta-analyses have reported conflicting results regarding the relationship between baseline uric acid (UA) levels and acute ischemic stroke (AIS) outcomes. Therefore, we conducted a dose–response meta-analysis to elucidate the association’s strength and shape. Studies on the association between baseline UA levels and AIS outcomes in the PubMed and EMBASE databases were searched from
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Transcriptomics and Metabolomics Unveil the Neuroprotection Mechanism of AnGong NiuHuang (AGNH) Pill Against Ischaemic Stroke Injury Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-24 Liangliang Tian, Guangzhao Cao, Xiaotong Zhu, Lihan Wang, Jingyi Hou, Yi Zhang, He Xu, Lixia Wang, Shicong Wang, Chen Zhao, Hongjun Yang, Jingjing Zhang
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NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer’s Disease Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-24 Zhi Tang, Zhuyi Chen, Min Guo, Yaqian Peng, Yan Xiao, Zhizhong Guan, Ruiqing Ni, Xiaolan Qi
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The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-23 Dejiang Pang, Yujiao Yu, Bi Zhao, Jingxuan Huang, Yiyuan Cui, Tengfei Li, Chunyu Li, Huifang Shang
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Effects of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Central Nervous System Diseases Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-23 Miao Chai, Gang Su, Wei Chen, Juan Gao, Qionghui Wu, Jinyang Song, Zhenchang Zhang
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Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Yinggang Xiao, Yang Zhang, Wenjuan Yuan, Cunjin Wang, Yali Ge, Tianfeng Huang, Ju Gao
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Genes in Axonal Regeneration Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Wenshuang Wu, Jing Zhang, Yu Chen, Qianqian Chen, Qianyan Liu, Fuchao Zhang, Shiying Li, Xinghui Wang
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Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Ki-Joong Kim, Jinyeon Hwang, Kang-Woo Lee, Jieun Kim, Yunha Han, Uk Namgung
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High Homocysteine-Thiolactone Leads to Reduced MENIN Protein Expression and an Impaired DNA Damage Response: Implications for Neural Tube Defects Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Baoling Bai, Chunlei Wan, Zonghui Xiao, Dan Li, Lingyun Liu, Kexin Zhang, Ting Zhang, Qin Zhang
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RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Junyi Zhao, Siyu Liu, Kunyu Li, Yulu Yang, Yue Zhao, Xinzhou Zhu
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Neuroinflammation Targeting Pyroptosis: Molecular Mechanisms and Therapeutic Perspectives in Stroke Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-22 Xiwen Yuan, Yiwen Xia, Pei Jiang, Jing Chen, Chunmei Wang
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Ferroptosis and Pyroptosis in Epilepsy Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-21 Fan Feng, Rong Luo, Dezhi Mu, Qianyun Cai
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Correction: Mitochondrial Transfusion Improves Mitochondrial Function Through Up-regulation of Mitochondrial Complex II Protein Subunit SDHB in the Hippocampus of Aged Mice Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-21 A. Adlimoghaddam, T. Benson, B. C. Albensi
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Considering Context-Specific microRNAs in Ischemic Stroke with Three “W”: Where, When, and What Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-21
Abstract MicroRNAs are short non-coding RNA molecules that function as critical regulators of various biological processes through negative regulation of gene expression post-transcriptionally. Recent studies have indicated that microRNAs are potential biomarkers for ischemic stroke. In this review, we first illustrate the pathogenesis of ischemic stroke and demonstrate the biogenesis and transportation
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Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-21 Yong Peng, Jiaoying Jia, Mingming Zhang, Wenjia Ma, Yan Cui, Mengqiang Yu
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Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats Mol. Neurobiol. (IF 5.1) Pub Date : 2024-02-20 Sarah E. Svirsky, Jeremy Henchir, Youming Li, Shaun W. Carlson, C. Edward Dixon