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Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-14 Belén Mollá, Miguel Heredia, Pascual Sanz
Lafora disease (LD; OMIM#274780) is a fatal rare neurodegenerative disorder characterized by generalized epileptic seizures and the presence of polyglucosan inclusions (PGs), called Lafora bodies (LBs), typically in the brain. LD is caused by mutations in two genes EPM2A or EPM2B, which encode respectively laforin, a glucan phosphatase, and malin, an E3-ubiquitin ligase. Much remains unknown about
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Improvement of Rat Spinal Cord Injury Following Lentiviral Vector-Transduced Neural Stem/Progenitor Cells Derived from Human Epileptic Brain Tissue Transplantation with a Self-assembling Peptide Scaffold Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-14 Sara Abdolahi, Hadi Aligholi, Azizollah Khodakaram-Tafti, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorji
Spinal cord injury (SCI) is a disabling neurological disorder that causes neural circuit dysfunction. Although various therapies have been applied to improve the neurological outcomes of SCI, little clinical progress has been achieved. Stem cell–based therapy aimed at restoring the lost cells and supporting micromilieu at the site of the injury has become a conceptually attractive option for tissue
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Cottonseed Oil Alleviates Ischemic Stroke-Induced Oxidative Stress Injury Via Activating the Nrf2 Signaling Pathway Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-14 Min Liu, Hao Li, Lixia Zhang, Zhipeng Xu, Yuxiang Song, Xiaoyan Wang, Ruitong Chu, Yunming Xiao, Miao Sun, Yulong Ma, Weidong Mi
Oxidative stress is believed to be one of the primary causes in ischemic stroke injury, and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is the most important endogenous antioxidative stress damage pathway. Cottonseed oil (CSO), which is used mostly as a solvent for lipid-soluble drugs, has been shown to exert antioxidative effects against peripheral tissue injury. However
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Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-13 Weisong Duan, Le Yi, Yunyun Tian, Huai-peng Huang, Zhongyao Li, Yue Bi, Moran Guo, Yuanyuan Li, Yakun Liu, Yanqin Ma, Xueqin Song, Yaling Liu, Chunyan Li
Background TANK-binding kinase1 (TBK1) haploinsufficiency has been shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the mechanism is unclear. Methods Myeloid Tbk1 knockout mice (Tbk1-LKO mice) were established and motor function and pathological analyses were also performed. The level of p-TBK1 was analyzed in the ALS animal model and in patient samples
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SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-13 Mohan Kumar Muthu Karuppan, Dinesh Devadoss, Madhavan Nair, Hitendra S. Chand, Madepalli K. Lakshmana
The recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of 2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both the scale and magnitude. Although the respiratory tract is the primary target of SARS-CoV-2, accumulating evidence suggests that the virus may also invade both the central nervous system (CNS) and the peripheral nervous system
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Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-11 Peiling Zhou, Meiping Deng, Jiashan Wu, Qinghui Lan, Huifang Yang, Changzheng Zhang
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition characterized by intrusive recollections of the traumatic event, avoidance behaviors, hyper-arousal to event-related cues, cognitive disruption, and mood dysregulation. Accumulating preclinical and clinical evidence implicates dysfunction of the ventral tegmental area (VTA) dopaminergic system in PTSD pathogenesis. This article
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LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF-κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-09 Pushpa Gandi Sangaran, Zaridatul Aini Ibrahim, Zamri Chik, Zahurin Mohamed, Abolhassan Ahmadiani
Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host
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Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington’s Disease Models Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-09 Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Proper development of neuronal cells is important for brain functions, and impairment of neuronal development may lead to neuronal disorders, implying that improvement in neuronal development may be a therapeutic direction for these diseases. Huntington’s disease (HD) is a neurodegenerative disease characterized by impairment of neuronal structures, ultimately leading to neuronal death and dysfunctions
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Aging-Dependent Mitophagy Dysfunction in Alzheimer’s Disease Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Mingxue Song, Xiulan Zhao, Fuyong Song
Alzheimer’s disease (AD) is the most common late-onset dementia characterized by the deposition of extracellular amyloid plaques and formation of intracellular neurofibrillary tangles, which eventually lead to neuronal loss and cognitive deficits. Multiple lines of evidence indicate that mitochondrial dysfunction is involved in the initiation and progression of AD. As essential machinery for mitochondrial
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Opioid System Contributes to the Trifluoromethyl-Substituted Diselenide Effectiveness in a Lifestyle-Induced Depression Mouse Model Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Sabrina Grendene Müller, Natália Silva Jardim, Milene Arrial Trindade, Cristina Wayne Nogueira
Energy-dense foods and ethanol consumption are associated with mood disorders. m-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] has been a prominent pharmacological target due to its antidepressant-like effects. This study investigated if the modulation of opioid and glucocorticoid receptors and its well-known antioxidant property contribute to the (m-CF3-PhSe)2 antidepressant-like effect in young
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Müller Glia-Mediated Retinal Regeneration Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Hui Gao, Luodan A, Xiaona Huang, Xi Chen, Haiwei Xu
Müller glia originate from neuroepithelium and are the principal glial cells in the retina. During retinal development, Müller glia are one of the last cell types to be born. In lower vertebrates, such as zebrafish, Müller glia possess a remarkable capacity for retinal regeneration following various forms of injury through a reprogramming process in which endogenous Müller glia proliferate and differentiate
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Membrane Depolarization Inhibits BIM EL Upregulation but Prevents Neuronal Apoptosis Primarily by Increasing Cellular GSH Levels Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Ali A. Alshamrani, James L. Franklin
Sympathetic neurons deprived of nerve growth factor (NGF) die by apoptosis. Chronic depolarization with elevated concentrations of extracellular potassium ([K+]E) supports long-term survival of these and other types of neurons in culture. While depolarization has long been used to support neuronal cultures, little is known about the mechanism. We explored how chronic depolarization of NGF-deprived
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The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS) Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Shannon Thomson, Karen A. Waters, Rita Machaalani
Low orexin levels in the hypothalamus, and abnormal brainstem expression levels of many neurotransmitter and receptor systems in infants who died suddenly during a sleep period and diagnosed as sudden infant death syndrome (SIDS), may be linked to abnormal protein unfolding. We studied neuronal expression of the three unfolded protein response (UPR) pathways in the human infant brainstem, hypothalamus
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Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Xiaokun Geng, Jiamei Shen, Fengwu Li, James Yip, Longfei Guan, Gary Rajah, Changya Peng, Donald DeGracia, Yuchuan Ding
To demonstrate the role of the rate-limiting and ATP-dependent gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PCK) in oxidative and lactic stress and the effect of phenothiazine on PCK after stroke, a total of 168 adult male Sprague Dawley rats (3 months old, 280–300 g) underwent 2-h intraluminal middle cerebral artery occlusion (MCAO) and reperfusion for 6, 24, 48 h, or 7 days. Phenothiazine
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Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer’s Disease Mice Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Gennadiy Fonar, Baruh Polis, Dev Sharan Sams, Almog Levi, Assaf Malka, Natalia Bal, Alexander Maltsev, Evan Elliott, Abraham O. Samson
Alzheimer’s disease (AD) is the most common cause of senile dementia and one of the greatest medical, social, and economic challenges. According to a dominant theory, amyloid-β (Aβ) peptide is a key AD pathogenic factor. Aβ-soluble species interfere with synaptic functions, aggregate gradually, form plaques, and trigger neurodegeneration. The AD-associated pathology affects numerous systems, though
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Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Noopur Bhore, Bo-Jeng Wang, Po-Fan Wu, Yen-Lurk Lee, Yun-Wen Chen, Wen-Ming Hsu, Hsinyu Lee, Yi-Shuian Huang, Ding-I Yang, Yung-Feng Liao
Dual-specificity phosphatases (DUSPs) comprise a unique group of enzymes that dephosphorylate signaling proteins at both phospho-serine/threonine and phospho-tyrosine residues. Since Notch signaling is an essential pathway for neuronal cell fate determination and development that is also upregulated in Alzheimer’s disease tissues, we sought to explore whether and how DUSPs may impact Notch processing
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Differential Age-Dependent Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Induced by Neonatal Hypoxia-Ischemia in the Immature Rat Brain Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Felipe Kawa Odorcyk, R. T. Ribeiro, A. C. Roginski, L. E. Duran-Carabali, N. S. Couto-Pereira, C. Dalmaz, M. Wajner, C. A. Netto
Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental changes observed is the mitochondrial function, namely, the tricarboxylic acid (TCA)
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Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Fabrízio dos Santos Cardoso, Júlio César Claudino dos Santos, Francisco Gonzalez-Lima, Bruno Henrique Silva Araújo, Rodrigo Álvaro Brandão Lopes-Martins, Sérgio Gomes da Silva
Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative
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Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPARα Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Hongjie Wang, Mohan Kumar Muthu Karuppan, Madhavan Nair, Madepalli K. Lakshmana
Nonamyloidogenic processing of amyloid precursor protein (APP) by augmenting ADAM10 is a promising therapeutic strategy for Alzheimer’s disease (AD). Therefore identification of molecular pathways that regulate ADAM10 expression is crucial. Autophagy is strongly dysregulated in AD, and TFEB was recently shown to be a master regulator of autophagy-lysosome pathway (ALP). Here, we report that TFEB expression
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Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Mahsa Dolatshahi, Mohammadmahdi Sabahi, Mohammad Hadi Aarabi
Along with emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, a myriad of neurologic symptoms, associated with structural brain changes, were reported. In this paper, we provide evidence to critically discuss the claim that the survived patients could possibly be at increased risk for neurodegenerative diseases via various mechanisms. This virus can directly
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NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-08 Ernest T. Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buch
Cocaine use disorder is a major health crisis that is associated with increased oxidative stress and neuroinflammation. While the role of NLRP3 inflammasome in mediating neuroinflammation is well-recognized, whether cocaine induces this response remains unexplored. Based on the premise that cocaine induces both reactive oxygen species (ROS) as well as microglial activation, we hypothesized that cocaine-mediated
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Alpha-Synuclein Antibody Characterization: Why Semantics Matters Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Tiago Fleming Outeiro
In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies in cell and animal models of disease suggest that oligomeric species of different proteins might be more toxic that the larger
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TSG101 Promotes the Proliferation, Migration, and Invasion of Human Glioma Cells by Regulating the AKT/GSK3β/β-Catenin and RhoC/Cofilin Pathways Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Yufu Zhu, Yang Xu, Tianze Chen, Yujian Zhang, Qiang Ma, Sunil Rauniyar, Lei Wang, Hengliang Shi
The tumor susceptibility gene 101 (TSG101) has been reported to play important roles in the development and progression of several human cancers, such as pancreatic cancer, prostate cancer, and hepatocellular carcinoma. However, its potential roles and underlined mechanisms in human glioma are still needed to be further clarified. This study was designed to assess the expression of TSG101 in glioma
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Hippocampal and Prefrontal Cortical Brain Tissue Levels of Irisin and GDF15 Receptor Subunits in Children Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Travis C. Jackson, Kiersten Gorse, Jeremy R. Herrmann, Patrick M. Kochanek
Cold-stress hormones (CSHs) stimulate thermogenesis and have direct neuroprotective effects on the brain. The obligatory receptor components of two new CSHs (irisin and growth differentiation factor-15 [GDF15]) were recently discovered. Irisin binds integrin-αV/β5 heterodimers while GDF-15 binds to the orphan receptor glial cell-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL). In
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Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2 Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Xin Qin, Michael G. Zaki, Zhicheng Chen, Elisabet Jakova, Zhi Ming, Francisco S. Cayabyab
Chronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and increased neuronal death. Still, the mechanisms responsible for this adenosine-mediated neuronal damage following hypoxia need to be fully elucidated.
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Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Matina Tsampoula, Isaak Tarampoulous, Ivi Antoniadou, Yassemi Koutmani, Dimitrios Gkikas, Kostas Vekrellis, Panagiotis K Politis
Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is actively involved in brain homeostasis. Thus, identification of novel regulators in adult neurogenesis could significantly contribute to new therapies. We have recently unraveled the regulatory role of NR5A2 (also known as LRH1), a druggable orphan nuclear receptor, in embryonic neurogenesis. However, its involvement in adult neurogenesis
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Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Mette Habekost, Per Qvist, Mark Denham, Ida E. Holm, Arne Lund Jørgensen
Neurons produced by reprogramming of other cell types are used to study cellular mechanisms of age-related neurodegenerative diseases. To model Alzheimer’s disease and other tauopathies, it is essential that alternative splicing of the MAPT transcript in these neurons produces the relevant tau isoforms. Human neurons derived from induced pluripotent stem cells, however, express tau isoform compositions
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Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalão, Maria José Alves Rocha
Sepsis promotes an inflammatory state in the central nervous system (CNS) that may cause autonomic, cognitive, and endocrine changes. Microglia, a resident immune cell of the CNS, is activated in several brain regions during sepsis, suggesting its participation in the central alterations observed in this disease. In this study, we aimed to investigate the role of microglial activation in the neuroendocrine
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Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Guang-Jie Liu, Tao Tao, Xiang-Sheng Zhang, Yue Lu, Ling-Yun Wu, Yong-Yue Gao, Han Wang, Hai-Bin Dai, Yan Zhou, Zong Zhuang, Chun-Hua Hang, Wei Li
Excessive inflammation is a major cause contributing to early brain injury (EBI) and is associated with negative or catastrophic outcomes of subarachnoid hemorrhage (SAH). Resolvin D1 (RvD1) exerts strong anti-inflammatory and pro-resolving effects on either acute or chronic inflammation of various origin. Henceforth, we hypothesized that RvD1 potentially attenuates excessive inflammation in EBI following
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Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Lijun Dai, Li Zou, Lanxia Meng, Guifen Qiang, Mingmin Yan, Zhentao Zhang
Cholesterol is an indispensable component of the cell membrane and plays vital roles in critical physiological processes. Brain cholesterol accounts for a large portion of total cholesterol in the human body, and its content must be tightly regulated to ensure normal brain function. Disorders of cholesterol metabolism in the brain are linked to neurodegenerative diseases, including Alzheimer’s disease
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Neuroprotective Effects of Testosterone in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Agustina Lara, Iván Esperante, Maria Meyer, Philippe Liere, Noelia Di Giorgio, Michael Schumacher, Rachida Guennoun, Gisella Gargiulo-Monachelli, Alejandro Federico De Nicola, Maria Claudia Gonzalez Deniselle
Patients suffering of amyotrophic lateral sclerosis (ALS) present motoneuron degeneration leading to muscle atrophy, dysphagia, and dysarthria. The Wobbler mouse, an animal model of ALS, shows a selective loss of motoneurons, astrocytosis, and microgliosis in the spinal cord. The incidence of ALS is greater in men; however, it increases in women after menopause, suggesting a role of sex steroids in
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Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Wenbin Jia, Gofarana Wilar, Ichiro Kawahata, An Cheng, Kohji Fukunaga
Nicotine causes psychological dependence through its interactions with nicotinic acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding protein 3 (FABP3) colocalizes with dopamine D2 receptors (D2Rs) in the dorsal striatum, and FABP3 deficiency leads to impaired D2R function. Moreover, D2R null mice do not exhibit increased nicotine-induced conditioned place preference
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Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Hu Lv, Ying Li, Qian Cheng, Jiawei Chen, Wei Chen
Numerous evidences have highlighted the efficient role of dexmedetomidine (DEX) in multi-organ protection. In the present study, the neuroprotective role of DEX on cerebral ischemic injury and the underlining signaling mechanisms were explored. In order to simulate cerebral ischemic injury, we performed middle cerebral artery occlusion in mice and oxygen-glucose deprivation in neurons. Immunohistochemistry
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Disrupted Excitatory Synaptic Contacts and Altered Neuronal Network Activity Underpins the Neurological Phenotype in PCDH19-Clustering Epilepsy (PCDH19-CE) Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Stefka Mincheva-Tasheva, Alvaro F. Nieto Guil, Claire C. Homan, Jozef Gecz, Paul Q. Thomas
PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellular mechanism underpinning the neurological phenotype remains unclear. Here, we investigate
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Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Dhivya Arasappan, Simon B. Eickhoff, Charles B. Nemeroff, Hans A. Hofmann, Mbemba Jabbi
Mood disorders represent a major cause of morbidity and mortality worldwide but the brain-related molecular pathophysiology in mood disorders remains largely undefined. Because the anterior insula is reduced in volume in patients with mood disorders, RNA was extracted from the anterior insula postmortem anterior insula of mood disorder samples and compared with unaffected controls for RNA-sequencing
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In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS) Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Emily K. Don, Alina Maschirow, Rowan A. W. Radford, Natalie M. Scherer, Andrés Vidal-Itriago, Alison Hogan, Cindy Maurel, Isabel Formella, Jack J. Stoddart, Thomas E. Hall, Albert Lee, Bingyang Shi, Nicholas J. Cole, Angela S. Laird, Andrew P. Badrock, Roger S. Chung, Marco Morsch
Amyotrophic lateral sclerosis (ALS) is a form of motor neuron disease (MND) that is characterized by the progressive loss of motor neurons within the spinal cord, brainstem, and motor cortex. Although ALS clinically manifests as a heterogeneous disease, with varying disease onset and survival, a unifying feature is the presence of ubiquitinated cytoplasmic protein inclusion aggregates containing TDP-43
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Lmo4 Deficiency Enhances Susceptibility to Cisplatin-Induced Cochlear Apoptosis and Hearing Loss Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Rita Rosati, Monazza Shahab, Vickram Ramkumar, Samson Jamesdaniel
Cisplatin, a potent chemotherapeutic drug, induces ototoxicity, which limits its clinical utility. Cisplatin-induced oxidative stress plays a causal role in cochlear apoptosis while the consequent nitrative stress leads to the nitration of LIM domain only 4 (LMO4), a transcriptional regulator, and decreases its cochlear expression levels. Here, we show a direct link between cochlear LMO4 and cisplatin-induced
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Functional Differences Between Two Kv1.1 RNA Editing Isoforms: a Comparative Study on Neuronal Overexpression in Mouse Prefrontal Cortex Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Liting Zhang, Zetong Peng, Wenjun Bian, Pingping Zhu, Bin Tang, Wei-Ping Liao, Tao Su
The Shaker-related potassium channel Kv1.1 subunit has important implications for controlling neuronal excitabilities. A particular recoding by A-to-I RNA editing at I400 of Kv1.1 mRNA is an underestimated mechanism for fine-tuning the properties of Kv1.1-containing channels. Knowledge about functional differences between edited (I400V) and non-edited Kv1.1 isoforms is insufficient, especially in neurons
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Inhibition of ASIC-Mediated Currents by Activation of Somatostatin 2 Receptors in Rat Dorsal Root Ganglion Neurons Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 Ting-Ting Liu, Shuang Wei, Ying Jin, Chun-Yu Qiu, Wang-Ping Hu
Somatostatin (SST) and its analogues like octreotide (OCT) have analgesic effect on a variety of pain through peripheral SST receptors (SSTRs). However, the precise molecular mechanisms have not yet been fully elucidated. This research aimed to identify possible antinociceptive mechanisms, showing functional links of the SSTR2 and acid-sensing ion channels (ASICs). Herein, we reported that OCT inhibited
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Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-07 G. Morris, A. J. Walker, K. Walder, M. Berk, W. Marx, A. F. Carvalho, M. Maes, B. K. Puri
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2. Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but instead travels to the nucleus, where it binds to a DNA promoter and initiates transcription of anti-oxidative genes. Nrf2 upregulation is associated with increased cellular levels of glutathione disulfide, glutathione peroxidase
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Exosome Release Is Modulated by the Mitochondrial-Lysosomal Crosstalk in Parkinson’s Disease Stress Conditions Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Fatema Currim, Jyoti Singh, Anjali Shinde, Dhruv Gohel, Milton Roy, Kritarth Singh, Shatakshi Shukla, Minal Mane, Hitesh Vasiyani, Rajesh Singh
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta region of the brain. The main pathological hallmark involves cytoplasmic inclusions of α-synuclein and mitochondrial dysfunction, which is observed in other part of the central nervous system other than SN suggesting the spread of pathogenesis
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Exploring the Genetic Association of the ABAT Gene with Alzheimer’s Disease Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Quanzhen Zheng, Rui Bi, Min Xu, Deng-Feng Zhang, Li-Wen Tan, Ya-Ping Lu, Yong-Gang Yao
Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer’s disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter. In this study, we performed an integrative study at the genetic
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Telmisartan Inhibits the NLRP3 Inflammasome by Activating the PI3K Pathway in Neural Stem Cells Injured by Oxygen-Glucose Deprivation Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Hyuk Sung Kwon, Jungsoon Ha, Ji Young Kim, Hyun-Hee Park, Eun-Hye Lee, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Seong-Ho Koh
Angiotensin II receptor blockers (ARBs) have been shown to exert neuroprotective effects by suppressing inflammatory and apoptotic responses. In the present study, the effects of the ARB telmisartan on the NLRP3 inflammasome induced by oxygen-glucose deprivation (OGD) in neural stem cells (NSCs) were investigated, as well as their possible association with the activation of the PI3K pathway. Cultured
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Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Sharifa Hasana, Md. Farhad Hossain, Maroua Jalouli, Md. Tanvir Kabir, Md. Giash Uddin, Mir Imam Ibne Wahed, Tapan Behl, May N. Bin-Jumah, Mohamed M. Abdel-Daim, Lotfi Aleya, Md. Sahab Uddin
The new coronavirus (CoV), called novel coronavirus disease 2019 (COVID-19), belongs to the Coronaviridae family which was originated from the sea market in Wuhan city in China, at the end of the year 2019. COVID-19 and severe acute respiratory syndrome (SARS) are belonging to the same family (Coronaviridae). The current outbreak of COVID-19 creates public concern and threats all over the world and
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Human HINT1 Mutant Proteins that Cause Axonal Motor Neuropathy Exhibit Anomalous Interactions with Partner Proteins Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Elsa Cortés-Montero, María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Javier Garzón-Niño
The 14 kDa histidine triad nucleotide-binding protein 1 (HINT1) is critical to maintain the normal function of motor neurons. Thus, a series of human HINT1 mutants cause autosomal recessive axonal neuropathy with neuromyotonia. HINT1 establishes a series of regulatory interactions with signaling proteins, some of which are enriched in motor neurons, such as the type 1 sigma receptor or intracellular
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AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Hiago Murilo Melo, Cristiane Ribeiro de Carvalho, Alexandre Ademar Hoeller, Jefferson Luiz Brum Marques, Marcelo Neves Linhares, Mark William Lopes, Guilherme Loureiro Fialho, Peter Wolf, Katia Lin, Zuner A. Bortolotto, Jeremy M. Henley, André D’Ávila, Rodrigo Bainy Leal, Roger Walz
The central autonomic network, which is connected to the limbic system structures including the amygdala (AMY) and anterior hippocampus (aHIP), regulates the sympathetic and parasympathetic modulation of visceromotor, neuroendocrine, pain, and behavior manifestations during stress responses. Heart rate variability (HRV) is useful to estimate the cardiac autonomic tone. The levels of phosphorylation
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Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-06 Roberta Eduarda Grolli, Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Adriana Remião Luzardo, João Quevedo, Gislaine Zilli Réus, Zuleide Maria Ignácio
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Trimethyltin Increases Intracellular Ca 2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-04 Milorad Dragić, Katarina Milićević, Marija Adžić, Ivana Stevanović, Milica Ninković, Ivana Grković, Pavle Andjus, Nadežda Nedeljković
Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or chronic disorder is accompanied by reactive gliosis, which could be categorized as detrimental (A1) of beneficial (A2) for nervous tissue. Another signature of pathological astrocyte activation is disturbed Ca2+ homeostasis, a common denominator of neurodegenerative
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Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-04 Angel Toval, Daniel Garrigos, Yevheniy Kutsenko, Miroljub Popović, Bruno Ribeiro Do-Couto, Nicanor Morales-Delgado, Kuei Y. Tseng, José Luis Ferran
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy physical and cognitive development in youth athletes. The central dopamine system is of great
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High Expression of Nicotinamide N -Methyltransferase in Patients with Sporadic Alzheimer’s Disease Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-02 Altin Kocinaj, Tabassum Chaudhury, Mohammed S. Uddin, Rashad R. Junaid, David B. Ramsden, Geshanthi Hondhamuni, Fábio Klamt, Linda Parsons, Richard B. Parsons
We have previously shown that the expression of nicotinamide N-methyltransferase (NNMT) is significantly increased in the brains of patients who have died of Parkinson’s disease (PD). In this study, we have compared the expression of NNMT in post-mortem medial temporal lobe, hippocampus and cerebellum of 10 Alzheimer’s disease (AD) and 9 non-disease control subjects using a combination of quantitative
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Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex Mol. Neurobiol. (IF 4.5) Pub Date : 2021-01-02 Michele Siqueira, Ana Paula Bérgamo Araujo, Flávia Carvalho Alcantara Gomes, Joice Stipursky
Ethanol consumption during pregnancy or lactation period can induce permanent damage to the development of the central nervous system (CNS), resulting in fetal alcohol spectrum disorders (FASD). CNS development depends on proper neural cells and blood vessel (BV) development and blood-brain barrier (BBB) establishment; however, little is known about how ethanol affects these events. Here, we investigated
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Correction to: Suppression of TLR4/NF-κB Signaling Pathway Improves Cerebral Ischemia–Reperfusion Injury in Rats Mol. Neurobiol. (IF 4.5) Pub Date : 2020-11-13 Hang Zhao, Zhuo Chen, Li-Juan Xie, Gui-Feng Liu
The original version of this article unfortunately has errors and should be corrected.
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Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-09-19 S W Carlson,H Q Yan,Y Li,J Henchir,X Ma,M S Young,M D Ikonomovic,C E Dixon
Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiological consequences on neuronal function. A growing body of evidence supports an important
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Dual Specificity Phosphatases Support Axon Plasticity and Viability. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-09-21 Ambika Chandrasekhar,Prashanth Komirishetty,Aparna Areti,Anand Krishnan,Douglas W Zochodne
In peripheral neuropathies, axonal degeneration (AxD) impairs the prognosis for recovery. Here, we describe a role for dual specificity phosphatases (DUSPs; MAP kinase phosphatases, MKPs), in supporting autonomous axon plasticity and viability. Both DUSPs 1 and 4 were identified within intact or axotomized sensory neurons. Knockdown of DUSP 1 or 4 independently or combined impaired neurite outgrowth
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Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-09-21 Ghazaleh Eskandari-Sedighi,Leonardo M Cortez,Jing Yang,Nathalie Daude,Klinton Shmeit,Valerie Sim,David Westaway
Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition to generate different aggregated species, and the correlation between each species
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Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-08-31 Asmaa Abdullah,Nuraqila Mohd Murshid,Suzana Makpol
In the human body, cell division and metabolism are expected to transpire uneventfully for approximately 25 years. Then, secondary metabolism and cell damage products accumulate, and ageing phenotypes are acquired, causing the progression of disease. Among these age-related diseases, neurodegenerative diseases have attracted considerable attention because of their irreversibility, the absence of effective
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Inhibiting ER Stress Weakens Neuronal Pyroptosis in a Mouse Acute Hemorrhagic Stroke Model. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-09-03 Guang Chen,Cheng Gao,Ya'nan Yan,Tao Wang,Chengliang Luo,Mingyang Zhang,Xiping Chen,Luyang Tao
Intracerebral hemorrhage (ICH) is a form of stroke, characterized by high morbidity and mortality and currently lacks specific therapy. ICH leads to endoplasmic reticulum (ER) stress, which can induce neurological impairment through crosstalk with programmed cell death (PCD). Pyroptosis, a newly discovered form of PCD, has received attention because of its close relationship with some certain diseases
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer's Disease by Mediating the miR-129/YAP1/JAG1 Axis. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-08-24 Weiying Sun,Jun Zhao,Chunzhi Li
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that leads to progressive cognitive, memory, and learning dysfunction that affects the aging population. Dexmedetomidine (Dex) might be beneficial for postoperative cognitive function in elderly patients. However, the exact mechanism underlying the protective role of Dex against cognitive impairment requires further elucidation
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Large-Scale Analysis Reveals Gene Signature for Survival Prediction in Primary Glioblastoma. Mol. Neurobiol. (IF 4.5) Pub Date : 2020-09-01 Birbal Prasad,Yongji Tian,Xinzhong Li
Glioblastoma multiforme (GBM) is the most aggressive and common primary central nervous system tumour. Despite extensive therapy, GBM patients usually have poor prognosis with a median survival of 12–15 months. Novel molecular biomarkers that can improve survival prediction and help with treatment strategies are still urgently required. Here we aimed to robustly identify a gene signature panel for
更新日期:2020-10-07