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Oxidative stress accompanies HIF1-dependent impairment of glucose metabolism in the hippocampus of adult rats survived prenatal severe hypoxia. Dev. Neurosci. (IF 2.9) Pub Date : 2023-11-17 Oleg Vetrovoy,Viktor Stratilov,Sofiya Potapova,Ekaterina Tyulkova
INTRODUCTION Many socially significant diseases are associated with prenatal developmental disorders. Previously, we showed the pathological role of hypoxia-inducible factor HIF1 in post-hypoxic reoxygenation. This study aimed to investigate the effect of prenatal severe hypoxia (PSH) on HIF1α protein expression as well as on HIF1-dependent activity of the pentose phosphate pathway (PPP) and anaerobic
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Transcranial Magnetic Stimulation for Developmental Neuropsychiatric Disorders with Inflammation. Dev. Neurosci. (IF 2.9) Pub Date : 2023-11-09 Sandeep Vaishnavi
BACKGROUND Transcranial Magnetic Stimulation (TMS) is a noninvasive brain stimulation technique that may potentially be helpful for neuropsychiatric symptoms of developmental disorders with inflammatory aspects. TMS utilizes a varying magnetic field to induce electrical changes in the brain. Repetitive use of TMS modulates plasticity at multiple levels, particularly at the synapse and network level
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Expanding Spectrum and Therapeutic Insights in Inflammatory Brain Disorders. Dev. Neurosci. (IF 2.9) Pub Date : 2023-11-07 Samuel J Pleasure
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Brain Injury Outcomes after Adjuvant Erythropoietin Neuroprotection for Moderate or Severe Neonatal Hypoxic-Ischemic Encephalopathy: A Report from the HEAL Trial. Dev. Neurosci. (IF 2.9) Pub Date : 2023-10-31 Jessica L Wisnowski,Sarah E Monsell,Stefan Bluml,Amy M Goodman,Yi Li,Bryan Comstock,Patrick Heagerty,Sandra E Juul,Yvonne W Wu,Robert C McKinstry,Amit Mathur,
INTRODUCTION Erythropoietin (Epo) is a putative neuroprotective therapy that did not improve overall outcomes in a phase 3 randomized controlled trial for neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). However, HIE is a heterogeneous disorder, and it remains to be determined whether Epo had beneficial effects on a subset of perinatal brain injuries. METHODS This study was a
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Expression analyses of C-terminal-binding protein 1 (CtBP1) during mouse brain development. Dev. Neurosci. (IF 2.9) Pub Date : 2023-10-31 Nanako Hamada,Tohru Matsuki,Ikuko Iwamoto,Takuma Nishijo,Mariko Noda,Hidenori Tabata,Atsuo Nakayama,Koh-Ichi Nagata
INTRODUCTION CtBP1 (C-terminal-binding protein 1) is a multi-functional protein with well-established roles as a transcriptional co-repressor in the nucleus and a regulator of membrane fission in the cytoplasm. Although CtBP1 gene abnormalities have been reported to cause neurodevelopmental disorders, the physiological role and expression profile of CtBP1 remains to be elucidated. METHODS In this study
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Therapeutic hypothermia is limited in preventing developmental impairments after neonatal hypoxia-ischemia. Dev. Neurosci. (IF 2.9) Pub Date : 2023-10-31 Ricardo Ribeiro Nunes,Isadora D'Ávila Tassinari,Janaína Zang,Mirella Kielek Galvan Andrade,Anna Clara Machado Colucci,Mariana Leivas Müller Hoff,Maikel Rosa De Oliveira,Ana Helena Paz,Luciano Stürmer de Fraga
The only current treatment for neonatal hypoxia-ischemia (HI) is therapeutic hypothermia (TH), which still shows some limitations. Specific effects of TH in the several processes involved in brain injury progression remain unclear. In this study, the effects of TH treatment on developmental parameters, behavioral outcomes, and peripheral leukocytes were evaluated in neonatal male and female rats. In
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ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-27 Xiaohong Yin,Keshun Xia,Song Peng,Bo Tan,Yaohui Huang,Mao Wang,Mingfang He
Glioblastoma (GBM) is the most prevalent and fatal form of brain tumor, which is associated with a poor prognosis. ATP-binding cassette subfamily F member 1 (ABCF1) is an E2 ubiquitin-conjugating enzyme, which is implicated in regulating immune responses and tumorigenesis. Aberrant E3 ubiquitylation has been evidenced in GBM. However, the role of ABCF1 in GBM needs to be further explored. The expression
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Post-infectious inflammation, autoimmunity, and OCD: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infection (PANDAS), and Pediatric Acute-onset Neuropsychiatric Disorder (PANS). Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-22 Allison Vreeland,Denise Calaprice,Noga Or-Geva,Richard E Frye,Dritan Agalliu,Herbert M Lachman,Christopher Pittenger,Stefano Pallanti,Kyle Williams,Meiqian Ma,Margo Thienemann,Antonella Gagliano,Elizabeth Mellins,Jennifer Frankovich
Post-infectious neuroinflammation has been implicated in multiple models of acute onset obsessive-compulsive disorder (OCD) including Sydenham's chorea (SC), pediatric acute-onset neuropsychiatric syndrome (PANS), and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). These conditions are associated with a range of autoantibodies which are thought to
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Prospects and pitfalls of plasma complement C4 in schizophrenia: building a better biomarker. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-21 Emily G Severance,Emese Prandovszky,Shuojia Yang,Flora Leister,Ashley Lea,Ching-Lien Wu,Ryad Tamouza,Marion Leboyer,Faith Dickerson,Robert H Yolken
Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors interacting during neurodevelopment. Infections, inflammation, and autoimmune diseases are over-represented in schizophrenia leading to immune system-centered hypotheses. Complement component C4 is genetically and neurobiologically associated with schizophrenia, and its
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New Insights into the Developmental Neurobiology of Brain Tumors. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-18 Timothy N Phoenix
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Preterm birth by cesarean section: the gut-brain axis, a key regulator of brain development. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-15 Cécile Morin,Cindy Bokobza,Bobbi Fleiss,Elisa L Hill-Yardin,Juliette Van Steenwinckel,Pierre Gressens
Understanding the long-term functional implications of gut microbial communities during the perinatal period is a bourgeoning area of research. Numerous studies have revealed the existence of a "gut-brain axis" and the impact of an alteration of gut microbiota composition in brain diseases. Recent research has highlighted how gut microbiota could affect brain development and behavior. Many factors
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miR-26a improves microglial activation and neuronal apoptosis in a rat model of cerebral infarction by regulating the TREM1-TLR4/MyD88/NF-κB axis. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-13 Daxiong Xu,Qi'an Guo
Emerging studies have indicated that abnormally expressed microRNAs (miRNAs) are related to the pathogenesis of cerebral ischemia. Nevertheless, the function of miR-26a in neuronal damage and microglial activation during cerebral infarction remains elusive. It was revealed that miR-26a was downregulated in oxygen-glucose deprivation (OGD)-treated microglia and neurons. Overexpressing miR-26a reduced
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CASE REPORT: Clinicopathologic characteristics of PANDAS in a young adult. Dev. Neurosci. (IF 2.9) Pub Date : 2023-09-12 Lakshmi Shree Kulumani Mahadevan,Melissa Murphy,Marina Selenica,Elizabeth Latimer,Brent T Harris
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections) is an acute onset or exacerbation of neuropsychiatric symptoms following a group A streptococcus (GAS) infection. It is believed to be a result of autoimmune response to streptococcal infection, but there is insufficient evidence to fully support this theory. Although this disease is primarily thought to
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From early motor ability to global cognitive development seven years after neonatal arterial ischemic stroke. Dev. Neurosci. (IF 2.9) Pub Date : 2023-08-30 Antoine Giraud,Pauline Garel,Brian H Walsh,Stéphane Chabrier
The developmental condition of children after neonatal arterial ischemic stroke (NAIS) is characterized by cognitive and motor impairments. We hypothesized that independent walking age would be a predictor of later global cognitive functioning in this population. Sixty-one children with an available independent walking age and full-scale IQ score seven years after NAIS were included in this study.
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MYC promotes aggressive growth and metastasis of a WNT-medulloblastoma mouse model. Dev. Neurosci. (IF 2.9) Pub Date : 2023-08-05 Rachel Hartley,Timothy N Phoenix
Medulloblastoma (MB), the most common malignant pediatric brain tumor, comprises four molecularly and clinically distinct subgroups (termed WNT, SHH, Group3, and Group4). Prognosis varies based on genetic and pathological features associated with each molecular subgroup. WNT-MB, considered low-risk, are rarely metastatic and contain activating mutations in CTNNB1; Group3-MB, commonly classified as
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Disrupted small-world networks in children with drug-naïve atten-tion-deficit/hyperactivity disorder: a DTI-based network analysis. Dev. Neurosci. (IF 2.9) Pub Date : 2023-08-02 Liuhui Wu,Shu Su,Yan Dai,Huaqiong Qiu,Liping Lin,Mengsha Zou,Long Qian,Meina Liu,Hongyu Zhang,Yingqian Chen,Zhiyun Yang
OBJECTIVES To explore the alterations in the white matter (WM) structural connectome in children with drug-naïve attention-deficit/hyperactivity disorder (ADHD). METHODS Forty-nine pediatric ADHD and 51 age- and gender-matched typically developing (TD) children aged 6-14 years old were enrolled. This cross-sectional study applied graph theoretical analysis to assess the white matter organization based
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Evaluating Injury Severity in Neonatal Encephalopathy Using Automated Quantitative Electroencephalography Analysis: A Pilot Study. Dev. Neurosci. (IF 2.9) Pub Date : 2023-07-19 Eva Catenaccio,Rachel J Smith,Raul Chavez-Valdez,Vera J Burton,Ernest Graham,Charlamaine Parkinson,Dhananjay Vaidya,Aylin Tekes,Frances J Northington,Allen D Everett,Carl E Stafstrom,Eva K Ritzl
Quantitative analysis of electroencephalography (qEEG) is a potential source of biomarkers for neonatal encephalopathy (NE). However, prior studies using qEEG in NE were limited in their generalizability due to individualized techniques for calculating qEEG features or labor-intensive pre-selection of EEG data. We piloted a fully automated method using commercially available software to calculate the
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Evaluation of C4 gene copy number in Pediatric Acute Neuropsychiatric Syndrome. Dev. Neurosci. (IF 2.9) Pub Date : 2023-06-28 Agnieszka Kalinowski,Lu Tian,Reenal Pattni,Hanna Ollila,Maroof Khan,Cindy Manko,Melissa Silverman,Meiqian Ma,Laurie Columbo,Bahare Farhadian,Susan Swedo,Tanya Murphy,Mats Johnson,Elisabeth Fernell,Christopher Gillberg,Margo Thienemann,Elizabeth D Mellins,Douglas F Levinson,Alexander E Urban,Jennifer Frankovich
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is an abrupt-onset neuropsychiatric disorder. PANS patients have an increased prevalence of co-morbid autoimmune illness, most commonly arthritis. In addition, an estimated one-third of PANS patients present with low serum C4 protein, suggesting decreased production or increased consumption of C4 protein. To test the possibility that copy number
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Neuroprotective Effects of Delayed TGF-β1 Receptor Antagonist Administration On Perinatal Hypoxic-Ischemic Brain Injury. Dev. Neurosci. (IF 2.9) Pub Date : 2023-06-22 Hur Dolunay Kanal,Steven W Levison
Hypoxic-ischemic (HI) brain injury in neonatal encephalopathy triggers a wave of neuroinflammatory events attributed to causing the progressive degeneration and functional deficits seen weeks after the primary damage. The cellular processes mediating this prolonged neurodegeneration in HI injury are not sufficiently understood. Consequently, current therapies are not fully protective. In a recent study
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Fluoxetine Can Cause Epileptogenesis and Aberrant Neurogenesis in Male Wild Type Mice. Dev. Neurosci. (IF 2.9) Pub Date : 2023-06-09 Ksenia Musaelyan,Mark A Horowitz,Stephen McHugh,Francis G Szele
Antidepressants in general, and fluoxetine in particular, increase adult hippocampal neurogenesis (AHN) in mice. Here we asked how the antidepressant fluoxetine affects behavior and AHN in a corticosterone model of depression. In three groups of adult male C57BL/6j mice we administered either vehicle (VEH), corticosterone (CORT) treatment to induce a depression-like state or corticosterone plus a standard
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Fetal origins of health disparities: transgenerational consequences of racism. Dev. Neurosci. (IF 2.9) Pub Date : 2023-06-08 Nana Matoba,James W Collins,Maria Dizon
Despite advances in perinatal medicine, racial disparity in birth outcomes remains a public health problem in the United States. The underlying mechanisms for this long-standing racial disparity are incompletely understood. This review presents transgenerational risk factors for racial disparities in preterm birth, exploring the impact of interpersonal and structural racism, theoretical models of stress
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Early gray matter structural covariance predicts longitudinal gain in arithmetic ability in children. Dev. Neurosci. (IF 2.9) Pub Date : 2023-06-06 Tian Ren,Zheng Li,Chunjie Wang,Bao-Ming Li
Previous neuroimaging studies on arithmetic development have mainly focused on functional activation or functional connectivity between brain regions. It remains largely unknown how brain structures support arithmetic development. The present study investigated whether early gray matter structural covariance contributes to later gain in arithmetic ability in children. We used a public longitudinal
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Hypothermia Treatment After Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-24 R Ann Sheldon,Christine Windsor,Fuxin Lu,Nicholas R Stewart,Xiangning Jiang,Donna M Ferriero
The developing brain is uniquely susceptible to oxidative stress and endogenous antioxidant mechanisms are not sufficient to prevent injury from a hypoxic-ischemic challenge. Glutathione peroxidase (GPX1) activity reduces hypoxic-ischemic injury. Therapeutic hypothermia also reduces hypoxic-ischemic injury, in the rodent and the human brain, but the benefit is limited. Here, we combined GPX1 overexpression
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Arthritis in children with psychiatric deteriorations: a case series. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-12 Meiqian Ma,Jesse Sandberg,Bahare Farhadian,Melissa Silverman,Yuhuan Xie,Margo Thienemann,Jennifer Frankovich
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS), Sydenham chorea and other post-infectious psychiatric deteriorations are thought to be caused by inflammatory/autoimmune mechanisms, likely involving the basal ganglia based on imaging studies. Patients have a relapsing-remitting course and some develop
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Pediatric Glioma Models Provide Insights into Tumor Development and Future Therapeutic Strategies. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-12 Amelia Foss,Manav Pathania
In depth study of pediatric gliomas has been hampered due to difficulties in accessing patient tissue and a lack of clinically-representative tumor models. Over the last decade, however, profiling of carefully curated cohorts of pediatric tumors has identified genetic drivers that molecularly segregate pediatric gliomas from adult gliomas. This information has inspired the development of a new set
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Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-10 Hannah Musco,Kate Beecher,Kirat K Chand,Paul B Colditz,Julie A Wixey
Fetal growth restriction (FGR) and small for gestational age (SGA) infants have increased risk of mortality and morbidity. Although both FGR and SGA infants have low birthweights for gestational age, a diagnosis of FGR also requires assessments of umbilical artery Doppler, physiological determinants, neonatal features of malnutrition and in utero growth retardation. Both FGR and SGA are associated
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Quantification of diffusion MRI for prognostic prediction of neonatal hypoxic-ischemic encephalopathy. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-10 Kengo Onda,Raul Chavez-Valdez,Ernest M Graham,Allen D Everett,Frances J Northington,Kenichi Oishi
Neonatal-hypoxic ischemic encephalopathy (HIE) is the leading cause of acquired neonatal brain injury with the risk of developing serious neurologic sequelae and death. An accurate and robust prediction of short- and long-term outcomes may provide clinicians and families with fundamental evidence for their decision-making, the design of treatment strategies, and the discussion of developmental intervention
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Characterization of gene regulatory elements in human fetal cortical development: Enhancing our understanding of neurodevelopmental disorders and evolution. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-10 Qiuyu Guo,Sarah Wu,Daniel H Geschwind
The neocortex is the region that most distinguishes human brain from other mammals and primates [1]. Studying the development of human cortex is important in understanding the evolutionary changes occurring in humans relative to other primates, as well as in elucidating mechanisms underlying neurodevelopmental disorders. Cortical development is a highly regulated process, spatially and temporally coordinated
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Out of Line or Altered States? Neural Progenitors as a target in a Polygenic Neurodevelopmental Disorder. Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-10 Shah Rukh,Daniel W Meechan,Thomas M Maynard,Anthony-Samuel Lamantia
The genesis of a mature complement of neurons is thought to require, at least in part, lineages in which neural progenitors have distinct identities recognized by exclusive expression of one or a few molecular markers. Nevertheless, limited progenitor types distinguished by specific markers and lineal progression through these subclasses cannot easily yield the magnitude of neuronal diversity in most
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Does perinatal intermittent hypoxia affect cerebrovascular network development? Dev. Neurosci. (IF 2.9) Pub Date : 2023-05-09 Vanessa Coelho-Santos,Anne-Jolene N Cruz,Andy Y Shih
Perinatal hypoxia is an inadequate delivery of oxygen to the fetus in the period immediately before, during, or after the birth process. The most frequent form of hypoxia occurring in human development is chronic intermittent hypoxia (CIH) due to sleep-disordered breathing (apnea) or bradycardia events. CIH incidence is particularly high with premature infants. During CIH, repetitive cycles of hypoxia
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Hippo Pathway in Schwann Cells and Regeneration of Peripheral Nervous System Dev. Neurosci. (IF 2.9) Pub Date : 2023-04-20 Jingyuan Wang, Haofeng Chen, Wulei Hou, Qingjian Han, Zuoyun Wang
Hippo pathway is an evolutionarily conserved signaling pathway consisting of a series of MST/LATS kinase complexes. Its key transcriptional co-activators YAP and TAZ regulate transcription factors such as TEAD family to direct gene expression. The regulation of Hippo pathway, especially the nuclear level change of YAP and TAZ, significantly influences the cell fate switching from proliferation to differentiation
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Developmental brain injury and social determinants of health: opportunities to combine preclinical models for mechanistic insights into recovery Dev. Neurosci. (IF 2.9) Pub Date : 2023-04-20 Danielle Guez-Barber, Amelia Eisch, Ana G. Cristancho
Epidemiological studies show that social determinants of health are amongst the strongest factors associated with developmental outcomes after prenatal and perinatal brain injuries, even when controlling for the severity of the initial injury. Elevated socioeconomic status and a higher level of parental education correlate with improved neurologic function after premature birth. Conversely, children
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In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice Dev. Neurosci. (IF 2.9) Pub Date : 2023-04-12 Takayuki Mitsuhashi, Satoko Hattori, Kimino Fujimura, Shinsuke Shibata, Tsuyoshi Miyakawa, Takao Takahashi
Valproic acid (VPA) is an antiepileptic drug that inhibits the epileptic activity of neurons mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit histone deacetylases, which epigenetically modify the cell proliferation/differentiation characteristics of stem/progenitor cells within developing tissues. Recent clinical studies in humans have indicated that VPA exposure
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Beyond the rainbow: a review of advanced lineage tracing methodologies for interrogating the initiation, evolution, and recurrence of brain tumors Dev. Neurosci. (IF 2.9) Pub Date : 2023-04-04 Sara Sabet, Joshua J. Breunig
The mammalian forebrain is perhaps the pinnacle of evolution and one of the most complex structures in known existence. The origin of this complexity and diversity partly lies in dynamic behavior of progenitors during embryonic neural development, all of which is under the control of regulatory mechanisms that ensure all the elements end up in the right place at the right time. Historically, dye-base
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Sexual dimorphism in the closure of the hippocampal postnatal critical period of synaptic plasticity after intrauterine growth restriction – link to oligodendrocyte and glial dysregulation Dev. Neurosci. (IF 2.9) Pub Date : 2023-04-05 Michael Nugent, Mark St. Pierre, Ashley Brown, Salma Nassar, Pritika Parmar, Yuma Kitase, Sarah Ann Duck, Charles Pinto, Lauren Jantzie, Camille Fung, Raul Chavez-Valdez
Intrauterine growth restriction (IUGR) resulting from hypertensive disease of pregnancy (HDP) leads to sexually dimorphic hippocampal-dependent cognitive and memory impairment in humans. In our translationally-relevant mouse model of IUGR incited by HDP, we have previously shown that the synaptic development in the dorsal hippocampus including GABAergic development, NPTX2+ excitatory synaptic formation
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Prenatal stress induces translational disruption associated with myelination deficits Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-31 Gabrielle K. Crombie, Hannah K. Palliser, Julia C Shaw, Bethany A Hanley, Roisin A Moloney, Jonathan J. Hirst
Background: Disruptions to neurodevelopment is known to be linked to behavioural disorders in childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter inhibitory GABAergic pathways and critical myelination processes programming long-term neurobehavioural disruption. The maturation of the GABAergic system into the major inhibitory pathway in the brain, and the development
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Dendrimer conjugated glutamate carboxypeptidase II inhibitor restores microglial changes in a rabbit model of cerebral palsy Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-29 Nirnath Sah, Zhi Zhang, Alicia Chime, Amanda Fowler, Antonio Mendez-Trendler, Anjali Sharma, Kannan Rangaramanujam, Barbara Slusher, Sujatha Kannan
We have previously shown that maternal endotoxin exposure leads to a phenotype of cerebral palsy and pro-inflammatory microglia in the brain in neonatal rabbits. ‘Activated’ microglia overexpress the enzyme glutamate carboxypeptidase II (GCPII) that hydrolyzes N-acetylaspartylglutamate (NAAG) to N-acetylaspartate (NAA) and glutamate, and we have shown previously that inhibiting microglial GCPII is
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A Proposed Human Structural Brain Connectivity Matrix in the Center for Morphometric Analysis Harvard-Oxford Atlas Framework: A historical perspective and future direction for enhancing the precision of human structural connectivity with a novel neuroanatomical typology. Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-28 Nikos Makris, Richard Rushmore, Jonathan Kaiser, Matthew Albaugh, Marek Kubicki, Yogesh Rathi, Fan Zhang, Lauren J. O'Donnell, Edward Yeterian, Verne S. Caviness, David N. Kennedy
A complete structural definition of the human nervous system must include delineation of its wiring diagram (e.g., [1]). The complete formulation of the human brain circuit diagram (BCD; [2]) has been hampered by an inability to determine connections in their entirety (i.e., not only pathway stems, but also origins and terminations). From a structural point of view, a neuroanatomic formulation of the
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The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-21 Sophia M Loewen, Adriano M. Chavesa, Colin J Murray, Marianela E. Traetta, Sophia E Burns, Keelin H. Pekarik , Marie-Ève Tremblay
Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors, including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA has been consistently recognized as a major risk factor for neurodevelopmental disorders, and this association seems to be especially important for viral infections, as viral exposure during pregnancy was associated
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Paternal Deprivation and Female Biparental Family Rearing Induce Dendritic and Synaptic Changes in Octodon degus: II. Nucleus Accumbens Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-09 Tony de Schultz, Katharina Braun, Joerg Bock
While the majority of studies on the importance of parental caregiving on offspring behavioral and brain development focus on the role of the mother, the paternal contribution is still an understudied topic. We investigated if growing up without paternal care affects dendritic and synaptic development in the nucleus accumbens of male and female offspring, and if replacement of the father by a female
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Alterations in the proteome of developing neocortical synaptosomes in the absence of MET signaling revealed by comparative proteomics Dev. Neurosci. (IF 2.9) Pub Date : 2023-03-07 Kathie L. Eagleson, Pat Levitt
Alterations in the expression of genes encoding proteins involved in synapse formation, maturation and function are a hallmark of many neurodevelopmental and psychiatric disorders. For example, there is reduced neocortical expression of the MET receptor tyrosine kinase (MET) transcript and protein in autism spectrum disorder and Rett syndrome. Preclinical in vivo and in vitro models manipulating MET
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Impact of macrocephaly, as an isolated trait, on EEG signal as measured by spectral power and multiscale entropy during the first year of life Dev. Neurosci. (IF 2.9) Pub Date : 2023-02-23 Gabriela López-Arango, Florence Deguire, Kristian Agbogba, Élisabeth Audet-Duchesne, Marc-Antoine Boucher, Inga S. Knoth, Ramy El-Jalbout, Amélie Damphousse, Samuel Kadoury, Sarah Lippé
Macrocephaly has been associated with neurodevelopmental disorders; however, it has been mainly studied in the context of pathological or high-risk populations and little is known about its impact, as an isolated trait, on brain development in general population. Electroencephalographic (EEG) power spectral density (PSD) and signal complexity have shown to be sensitive to neurodevelopment and its alterations
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Maternal immune activation by poly (I:C) exposure causes cerebral cortical dysgenesis through dysregulated cell cycle kinetics of neural stem/progenitor cells Dev. Neurosci. (IF 2.9) Pub Date : 2023-01-24 Marie Sasaki, Takayuki Mitsuhashi, Fumiko Goto, Shinsuke Shibata, Ken-ichiro Kubo, Shinju Oku, Akihiro Owashi, Takao Takahashi
Maternal immune activation reportedly causes dysregulation of the cell cycle in stem cells, and impairment of higher cortical function in rodents. Furthermore, in humans’ maternal immune activation during the first to second trimester of pregnancy is strongly correlated with increased incidence of autism spectrum disorder in the offspring. Here, we show that in utero exposure to polyinosinic-polycytidylic
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Cilia at the Crossroads of Tumor Treating Fields and Chemotherapy Dev. Neurosci. (IF 2.9) Pub Date : 2023-01-17 Loic P. Deleyrolle, Matthew R. Sarkisian
Glioblastoma (GBM), the most common and lethal primary brain tumor in adults, requires multi-treatment intervention which unfortunately barely shifts the needle in overall survival. The treatment options after diagnosis and surgical resection (if possible) include irradiation, temozolomide (TMZ) chemotherapy, and now Tumor Treating Fields (TTFields). TTFields are electric fields delivered locoregionally
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Caspase-3 inhibition toward perinatal protection of the developing brain from environmental stress Dev. Neurosci. (IF 2.9) Pub Date : 2023-01-13 Anna Arjun Kaji, Masaaki Torii, Seiji Ishii
Throughout our lives, we are exposed to a variety of hazards, such as environmental pollutants and chemical substances that affect our health, and viruses and bacteria that cause infectious diseases. These external factors that are undesirable to an organism are called environmental stress. During the perinatal period, when neural networks are drastically reorganized and refined, the tolerance of the
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Expression analyses of Rich2/Arhgap44, a Rho family GTPase-activating protein, during mouse brain development Dev. Neurosci. (IF 2.9) Pub Date : 2023-01-11 Naoki Goto, Masashi Nishikawa, Hidenori Ito, Mariko Noda, Nanako Hamada, Hidenori Tabata, Makoto Kinoshita, Koh-ichi Nagata
Rho family small GTPases, such as Rho, Rac, and Cdc42, play essential roles during brain development, through regulating cellular signaling and actin cytoskeletal reorganization. Rich2/Arhgap44, a Rac- and Cdc42-specific GTPase-activating protein, has been reported to be a key regulator for dendritic spine morphology and synaptic function. Given the essential roles of Rac and Cdc42 in brain development
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Microglial characterisation in transient human neurodevelopmental structures Dev. Neurosci. (IF 2.9) Pub Date : 2023-01-05 David A. Menassa, Janja Kopić, Alisa Junaković, Ivica Kostovic, Željka Krsnik
Human neurodevelopment is characterised by the appearance, development and disappearance or transformation of various transient structures that underlie the establishment of connectivity within and between future cortical and subcortical areas. Examples of transient structures in the forebrain (amongst many others) include the subpial granular layer and the subplate zone. We have previously characterised
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Auditory Outcomes in Adolescents with Prenatal Alcohol Exposure Dev. Neurosci. (IF 2.9) Pub Date : 2022-12-29 Humberto de Oliveira Simões, Eduardo Tanaka Massuda, Erikson Felipe Furtado, Sthella Zanchetta
Investigate three aspects of auditory function (auditory acuity, cochlear dysfunction, and auditory processing) in adolescents with fetal alcohol exposure without phenotypic changes. Fifty-one adolescents with and without intrauterine exposure to alcohol were selected from a cohort study. The summons, evaluation, and analysis of the results were carried out blindly regarding the respective exposure
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Cross-sectional Observational Study of Typical in-utero Fetal Movements using Machine Learning Dev. Neurosci. (IF 2.9) Pub Date : 2022-12-20 Lana Vasung, Junshen Xu, Esra Abaci-Turk, Cindy Zhou, Elizabeth Holland, William H. Barth, Carol Barnewolt, Susan Connolly, Judy Estroff, Polina Golland, Henry A. Feldman, Elfar Adalsteinsson, P. Ellen Grant
Early variations of fetal movements are the hallmark of a healthy developing central nervous system. However, there are no automatic methods to quantify the complex 3D motion of the developing fetus in-utero. The aim of this prospective study was to use machine learning (ML) on in-utero MRI to perform quantitative kinematic analysis of fetal limb movement, assessing the impact of maternal, placental
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Neurochemical profile of BRAFV600E/AktT308D/S473D mouse gangliogliomas reveals impaired GABAergic system inhibition Dev. Neurosci. (IF 2.9) Pub Date : 2022-12-20 Maria Kyriazi, Philipp Müller, Julika Pitsch, Karen M.J. van Loo, Anne Quatraccioni, Thoralf Opitz, Susanne Schoch, Albert J. Becker, Silvia Cases-Cunillera
Gangliogliomas (GGs), composed of dysmorphic neurons and neoplastic astroglia, represent the most frequent tumor entity associated with chronic recurrent epileptic seizures. So far, a systematic analysis of potential differences in neurochemical profiles of dysmorphic tumoral neurons as well as neurons of the peritumoral microenvironment (PTME) was hampered by the inability to unequivocally differentiate
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miR-506-3p relieves neuropathic pain following brachial plexus avulsion via mitigating microglial activation through targeting the CCL2-CCR2 axis Dev. Neurosci. (IF 2.9) Pub Date : 2022-12-05
Neuroinflammation results in neuropathic pain following brachial plexus avulsion (BPA). This research was designed for investigating the function of miR-506-3p in BPA-induced neuropathic pain (NP). A total brachial plexus root avulsion (tBPRA) model was produced in adult rats as well as IL-1β-treated motoneuron-like NSC-34 cells and the LPS-treated microglia cell line BV2 for in vivo and in vitro experiments
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miR-506-3p relieves neuropathic pain following brachial plexus avulsion via mitigating microglial activation through targeting the CCL2-CCR2 axis Dev. Neurosci. (IF 2.9) Pub Date : 2022-12-05 Xing Jin, Wei Zheng, Songyuan Chi, Taihao Cui, Wei He
Neuroinflammation results in neuropathic pain following brachial plexus avulsion (BPA). This research was designed for investigating the function of miR-506-3p in BPA-induced neuropathic pain (NP). A total brachial plexus root avulsion (tBPRA) model was produced in adult rats as well as IL-1β-treated motoneuron-like NSC-34 cells and the LPS-treated microglia cell line BV2 for in vivo and in vitro experiments
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Progesterone as a neuroprotective agent in neonatal hypoxic-ischaemic encephalopathy - a systematic review Dev. Neurosci. (IF 2.9) Pub Date : 2022-11-25 Ming-Te Lee, Rosin McNicholas, Lawrence Miall, Nigel Simpson, Kevin C.W. Goss, Nicola J. Robertson, Paul Chumas
Hypoxic-ischaemic encephalopathy (HIE) in the newborn baby is a major contributor to neonatal mortality and morbidity across the world. Therapeutic hypothermia (HT) is the current standard treatment for moderate to severe HIE, but not all babies benefit. Potential neuroprotective actions of PROG include anti-apoptotic, anti-inflammatory and anti-oxidative effects and reduction of energy depletion,
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Progesterone as a neuroprotective agent in neonatal hypoxic-ischaemic encephalopathy - a systematic review Dev. Neurosci. (IF 2.9) Pub Date : 2022-11-25
Hypoxic-ischaemic encephalopathy (HIE) in the newborn baby is a major contributor to neonatal mortality and morbidity across the world. Therapeutic hypothermia (HT) is the current standard treatment for moderate to severe HIE, but not all babies benefit. Potential neuroprotective actions of PROG include anti-apoptotic, anti-inflammatory and anti-oxidative effects and reduction of energy depletion,
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Association of Nogo-A gene polymorphisms with cerebral palsy in Southern China: a case-control study Dev. Neurosci. (IF 2.9) Pub Date : 2022-11-02 Yuxin Wang, Lu He, Jingyu Huang, Jinling Li, Liru Liu, Yunxian Xu, Tingting Peng, Xubo Yang, Yiting Zhao, Chaoqiong Fu, Shiya Huang, Hongmei Tang, Kaishou Xu
Cerebral palsy (CP) is a motor and postural disorder syndrome caused by the nonprogressive dysfunction of the developing brain. Previous studies strongly indicated that the Nogo-A gene might be related to the pathogenesis of CP. The objective of this research was to explore the relationship between Nogo-A polymorphisms (rs1012603, rs12464595 and rs2864052) and CP in Southern China. The Hardy-Weinberg
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Association of Nogo-A gene polymorphisms with cerebral palsy in Southern China: a case-control study Dev. Neurosci. (IF 2.9) Pub Date : 2022-11-02
Cerebral palsy (CP) is a motor and postural disorder syndrome caused by the nonprogressive dysfunction of the developing brain. Previous studies strongly indicated that the Nogo-A gene might be related to the pathogenesis of CP. The objective of this research was to explore the relationship between Nogo-A polymorphisms (rs1012603, rs12464595 and rs2864052) and CP in Southern China. The Hardy-Weinberg
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Orthographic depth may influence the degree of severity of maze learning performance in children at risk for reading disorder Dev. Neurosci. (IF 2.9) Pub Date : 2022-10-12 Lisa A. Gabel, Alexandria Battison, Dongnhu T. Truong, Esther R. Lindström, Kelsey Voss, Yih-Choung Yu, Sorawit Roongruengratanakul, Khaknazar Shyntassov, Samantha Riebesell, Nicole Toumanios, Christiana M. Nielsen-Pheiffer, Steven Paniagua, Jeffrey R. Gruen
Reading disability (RD), which affect between 5-17% of the population worldwide, is the most prevalent form of learning disability, and is associated with underactivation of a universal reading network in children. However, recent research suggests there are differences in learning rates on cognitive predictors of reading performance, as well as differences in activation patterns within the reading
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Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder Dev. Neurosci. (IF 2.9) Pub Date : 2022-10-12
Reading disability (RD), which affects between 5 and 17% of the population worldwide, is the most prevalent form of learning disability, and is associated with underactivation of a universal reading network in children. However, recent research suggests there are differences in learning rates on cognitive predictors of reading performance, as well as differences in activation patterns within the reading