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The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors Dev. Neurosci. (IF 3.041) Pub Date : 2021-01-20 Daniel J. Merk; Pengcheng Zhou; Samuel M. Cohen; Maria F. Pazyra-Murphy; Grace H. Hwang; Kristina J. Rehm; Jose Alfaro; Christopher M. Reid; Xuesong Zhao; Eunyoung Park; Pin-Xian Xu; Jennifer A. Chan; Michael J. Eck; Kellie J. Nazemi; Corey C. Harwell; Rosalind A. Segal
During neural development, stem and precursor cells can divide either symmetrically or asymmetrically. The transition between symmetric and asymmetric cell divisions is a major determinant of precursor cell expansion and neural differentiation, but the underlying mechanisms that regulate this transition are not well understood. Here, we identify the Sonic hedgehog (Shh) pathway as a critical determinant
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Long-Term Effects of Prenatal Severe Hypoxia on Central and Peripheral Components of the Glucocorticoid System in Rats Dev. Neurosci. (IF 3.041) Pub Date : 2021-01-13 Oleg Vetrovoy; Ekaterina Tyulkova; Viktor Stratilov; Kseniia Baranova; Peter Nimiritsky; Pavel Makarevich; Elena Rybnikova
Introduction: Prenatal hypoxia is a risk factor for the development of numerous neurological disorders. It is known that the maternal stress response to hypoxia determines the epigenetic impairment of the perinatal expression of glucocorticoid receptors (GR) in the hippocampus of the progeny, but so far no detailed study of how this affects the functional state of the glucocorticoid system during further
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Prenatal High-Fat Diet Rescues Communication Deficits in Fmr1 Mutant Mice in a Sex-Specific Manner Dev. Neurosci. (IF 3.041) Pub Date : 2021-01-04 Suzanne O. Nolan; Samantha L. Hodges; James T. Okoh; Matthew S. Binder; Joaquin N. Lugo
Using high-throughput analysis methods, the present study sought to determine the impact of prenatal high-fat dietary manipulations on isolation-induced ultrasonic vocalization production in both male and female Fmr1mutants on postnatal day 9. Prior to breeding, male FVB/129 Fmr1 wildtype and female Fmr1 heterozygous breeding pairs were assigned to 1 of 3 diet conditions: standard lab chow, omega-3
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Long-Term Decreases in the Expression of Calcineurin and GABAA Receptors Induced by Early Maternal Separation Are Associated with Increased Anxiety-Like Behavior in Adult Male Rats Dev. Neurosci. (IF 3.041) Pub Date : 2020-12-18 Maryam Mahmoodkhani; Maedeh Ghasemi; Leila Derafshpour; Mohammad Amini; Nasrin Mehranfard
Introduction: Early life stress is a well-described risk factor of anxiety disorders in adulthood. Dysfunction in GABA/glutamate receptors and their functional regulator, calcineurin, is linked to anxiety disorders. Here, we investigated the effect of early life stress, such as repeated maternal separation (MS; 3 h per day from postnatal day [P] 2 to 11), on changes in the expression of calcineurin
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Morphological Characterization of the Developing Greater Cane Rat (Thryonomys swinderianus) Brain Dev. Neurosci. (IF 3.041) Pub Date : 2020-12-15 Oluwaseun Mustapha; Oluwaseun Ezekiel; Francis Olaolorun; Michael Awala-Ajakaiye; Eniola Popoola; Matthew Olude; James Olopade
Developmental mode along the altricial-precocial spectrum is well known to be influenced by brain development and maturation. The greater cane rat (GCR) is an indigenous precocial African rodent with uncommon phenotypes and life traits. This study was therefore designed to characterize and describe distinctive external developmental features in the prenatal GCR brain across the entire gestational length
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Sulforaphane Protects Piglet Brains from Neonatal Hypoxic-Ischemic Injury Dev. Neurosci. (IF 3.041) Pub Date : 2020-12-10 Bing Wang; Ewa Kulikowicz; Jennifer K. Lee; Raymond C. Koehler; Zeng-Jin Yang
The striatal, primary sensorimotor cortical, and thalamic neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI that exhibits similar selective regional vulnerability, we tested the hypothesis that early treatment with sulforaphane, an activator of the Nrf2 transcription factor, protects vulnerable neurons from HI injury. Anesthetized piglets (aged 3–7 days)
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miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3 Dev. Neurosci. (IF 3.041) Pub Date : 2020-10-30 Song Yi; Chuqin Zhang; Na Li; Yajing Fu; Hongkun Li; Jun Zhang
Objective: Recent reports have corroborated that microRNAs (miRs) are related to the pathological changes of cerebral ischemia-reperfusion (CIR) induced injury. This work aimed to unearth the role and potential mechanism of miR-325-3p in regulating neuronal survival in CIR injury. Methods: To conduct this investigation, we established an in vitro model of CIR injury by subjecting neurons to oxygen-glucose
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TrkC Overexpression Protects Sevoflurane-Induced Neurotoxicity in Human Induced Pluripotent Stem Cell-Derived Neurons Dev. Neurosci. (IF 3.041) Pub Date : 2020-10-26 Jun Zhang; Zhifu Chen; Xiaoyan Luo; Zhoujing Yang
Background: Inhaled anesthetic sevoflurane (SEVO) may induce cortical neurotoxicity and memory dysfunction in both animals and humans. In this study, we investigated the toxic effects of SEVO on human induced pluripotent stem cell (iPS)-derived neurons. Methods: Human iPS-derived neurons were exposed to SEVO in vitro. SEVO-induced toxic effects were examined with the viability, live caspase 3/7, and
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Caffeine Restores Background EEG Activity Independent of Infarct Reduction after Neonatal Hypoxic Ischemic Brain Injury. Dev. Neurosci. (IF 3.041) Pub Date : 2020-08-18 Haiyan Sun,Fernando Gonzalez,Patrick S McQuillen
In human preterm newborns, caffeine increases brain activity and improves neurodevelopmental outcomes. In animal models of hypoxic ischemic brain injury, caffeine pretreatment reduces infarct volume. We studied the relationship between tissue neuroprotection and brain activity after injury to further understand caffeine neuroprotection. Rat dams received caffeine prior to birth or on postnatal day
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A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism. Dev. Neurosci. (IF 3.041) Pub Date : 2020-08-18 Devahuti Chaliha,Matthew Albrecht,Mauro Vaccarezza,Ryu Takechi,Virginie Lam,Hani Al-Salami,John Mamo
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, few pharmacological treatments exist to alleviate these socio-behavioural impairments. Prenatal administration of valproic acid (VPA) has become an accepted animal model of ASD and has been extensively used to explore
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Publisher's Note. Dev. Neurosci. (IF 3.041) Pub Date : 2020-07-16 J. LoTurco; Steven Levison; Sidhartha Tan; Pradeep G. Bhide; Kazuhiro Ikenaka; Jean M. Lauder; Richard S. Nowakowski; Carina Mallard; Francis Szele; J. V. Nixon; M.S. Levine; K. Ikenaka; Gregg D. Stanwood; Richard H. Dyck; Beth Stevens; Michael Andrew Fox; Hideyuki Okano; Akiko Nishiyama; Flávia C. Gomes; Arnold R. Kriegstein; Zhengang Yang; Susan Vannucci; Tarik F. Haydar; James E. Goldman; Jane E
Dev Neurosci
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The Development of Adolescent Chronic Pain following Traumatic Brain Injury and Surgery: The Role of Diet and Early Life Stress. Dev. Neurosci. (IF 3.041) Pub Date : 2020-07-10 Sabrina Salberg,Marissa Sgro,Rhys D Brady,Melanie Noel,Richelle Mychasiuk
Pain is evolutionarily necessary for survival in that it reduces tissue damage by signaling the body to respond to a harmful stimulus. However, in many circumstances, acute pain becomes chronic, and this is often dysfunctional. Adolescent chronic pain is a growing epidemic with an unknown etiology and limited effective treatment options. Given that the relationship between acute pain and chronic pain
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Positive Modulation of SK Channel Impedes Neuron-Specific Cytoskeletal Organization and Maturation. Dev. Neurosci. (IF 3.041) Pub Date : 2020-06-24 Amita Shrestha,Razia Sultana,Philip A Adeniyi,Charles C Lee,Olalekan M Ogundele
N-methyl-D-aspartate receptor (NMDAR) modulates the structural plasticity of dendritic spines by impacting cytoskeletal organization and kinase signaling. In the developing nervous system, activation of NMDAR is pertinent for neuronal migration, neurite differentiation, and cellular organization. Given that small conductance potassium channels (SK2/3) repress NMDAR ionotropic signaling, this study
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A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C. Dev. Neurosci. (IF 3.041) Pub Date : 2020-06-22 Alkisti Mikrogeorgiou,Yiran Chen,Byong Sop Lee,Robert Bok,R Ann Sheldon,A James Barkovich,Duan Xu,Donna M Ferriero
Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate
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Acute Lengthening of Progenitor Mitosis Influences Progeny Fate during Cortical Development in vivo. Dev. Neurosci. (IF 3.041) Pub Date : 2020-06-15 Aaron Mitchell-Dick,Andrea Chalem,Louis-Jan Pilaz,Debra L Silver
Background/Aims: Prenatal microcephaly is posited to arise from aberrant mitosis of neural progenitors, which disrupts both neuronal production and survival. Although microcephaly has both a genetic and environmental etiology, the mechanisms by which dysregulation of mitosis causes microcephaly are poorly understood. We previously discovered that prolonged mitosis of mouse neural progenitors, either
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Socioeconomic Status in Infancy and the Developing Brain: Functional Connectivity of the Hippocampus and Amygdala. Dev. Neurosci. (IF 3.041) Pub Date : 2020-06-09 Fanny Dégeilh,Miriam H Beauchamp,Élizabel Leblanc,Véronique Daneault,Annie Bernier
The development of the hippocampus and amygdala is particularly sensitive to environmental factors, including socioeconomic status (SES). Studies that have investigated associations between SES and brain development markers have rarely focused on connectivity. Accordingly, this longitudinal study examined whether SES in infancy (parental education and income-to-needs ratio) predicts the functional
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Deficit of Long-Term Potentiation Induction, but Not Maintenance, in the Juvenile Hippocampus after Neonatal Proinflammatory Stress. Dev. Neurosci. (IF 3.041) Pub Date : 2020-05-05 Irina Kudryashova,Mikhail Stepanichev,Anna Manolova,Natalia Gulyaeva
CA3-CA1 long-term potentiation (LTP) in the hippocampal slices from juvenile Wistar rats was studied to reveal factors potentially contributing to different sensitivity to neonatal proinflammatory stress (NPS). NPS was induced by intraperitoneal injections of bacterial lipopolysaccharide (LPS) to neonatal rats (two injections of LPS, or saline in the control group, consecutively on postnatal days
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White Matter Alterations in Fmr1 Knockout Mice during Early Postnatal Brain Development. Dev. Neurosci. (IF 3.041) Pub Date : 2020-04-29 Da Shi,Su Xu,Jiachen Zhuo,Mary C McKenna,Rao P Gullapalli
Fragile X syndrome (FXS) is the most commonly inherited form of intellectual disability ascribed to the autism spectrum disorder. Studies with FXS patients have reported altered white matter volume compared to controls. The Fmr1 knockout (KO) mouse, a model for FXS, showed evidence of delayed myelination during postnatal brain development. In this study, we examined several white matter regions in
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Maternal Undernourishment in Guinea Pigs Leads to Fetal Growth Restriction with Increased Hypoxic Cells and Oxidative Stress in the Brain. Dev. Neurosci. (IF 3.041) Pub Date : 2020-04-21 Yohei Maki,Karen Nygard,Robert R Hammond,Timothy R H Regnault,Bryan S Richardson
Background: We determined whether maternal nutrient restriction (MNR) in guinea pigs leading to fetal growth restriction (FGR) impacts markers for brain hypoxia and oxidative stress. Methods: Guinea pigs were fed ad libitum (control) or 70% of the control diet before pregnancy, switching to 90% at mid-pregnancy (MNR). Near term, hypoxyprobe-1 (HP-1) was injected into pregnant sows. Fetuses were then
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Integrated Effects of Neonatal Ventral Hippocampal Lesions and Impoverished Social-Environmental Rearing on Endophenotypes of Mental Illness and Addiction Vulnerability. Dev. Neurosci. (IF 3.041) Pub Date : 2020-03-11 Robert Andrew Chambers,Alena M Sentir
A wide range of mental illnesses show high rates of addiction comorbidities regardless of their genetic, neurodevelopmental, and/or adverse-environmental etiologies. Understanding how the spectrum of mental illnesses produce addiction vulnerability will be key to discovering more effective preventions and integrated treatments for adults with addiction and dual diagnosis comorbidities. A population
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Combined Treatment with Insulin-Like Growth Factor 1 and AMD3100 Improves Motor Outcome in a Murine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Dev. Neurosci. (IF 3.041) Pub Date : 2020-02-13 Eric S Peeples,Alicia Dafferner,Jiang Jiang,Elizabeth Lyden,Michael Punsoni,Devendra K Agrawal
Stem cell transplantation is a promising intervention for neonatal hypoxic-ischemic encephalopathy (HIE); however, universal feasibility and safety have not been thoroughly evaluated. AMD3100 and insulin-like growth factor 1 (IGF1) mobilize progenitor cells into peripheral circulation. The objective of this study was to assess the short-term efficacy of inducing endogenous stem cell mobilization after
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Physical Activity and Spatial Memory Are Minimally Affected by Moderate Growth Restriction in Preterm Piglets. Dev. Neurosci. (IF 3.041) Pub Date : 2020-02-03 Muqing Cao,Anders Brunse,Thomas Thymann,Per Torp Sangild
Background: Preterm birth is associated with impaired brain functions, but it is unknown whether fetal growth restriction (GR) makes these deficits worse. Using piglets as a model for preterm infants, we hypothesized that moderate GR reduces growth rate, physical activity, and spatial memory in the first weeks after preterm birth. Methods: Preterm pigs were delivered by caesarean section and fed until
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Delayed Auditory Evoked Responses in Autism Spectrum Disorder across the Life Span. Dev. Neurosci. (IF 3.041) Pub Date : 2020-01-31 Junko Matsuzaki,Matthew Ku,Marissa Dipiero,Taylor Chiang,Joni Saby,Lisa Blaskey,Emily S Kuschner,Mina Kim,Jeffrey I Berman,Luke Bloy,Yu-Han Chen,John Dell,Song Liu,Edward S Brodkin,David Embick,Timothy P L Roberts
The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of the neural correlates of auditory processing through development from children into
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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model. Dev. Neurosci. (IF 3.041) Pub Date : 2020-01-28 Åsa Jungner,Suvi Vallius Kvist,Olga Romantsik,Matteo Bruschettini,Claes Ekström,Ivo Bendix,Josephine Herz,Ursula Felderhoff-Mueser,Adnan Bibic,René In Apos T Zandt,Magnus Gram,David Ley
Neonates born with critical congenital heart defects are at risk of diffuse white matter injuries and neurodevelopmental impairments. This study aimed to determine the impact of circulating cell-free hemoglobin and hyperoxia, both present during cardiopulmonary bypass circulation, on white matter brain development. Postnatal day 6 rat pups were injected intraperitoneally with cell-free Hb or vehicle
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Regulation of Central Nervous System Development by Class I Histone Deacetylases. Dev. Neurosci. (IF 3.041) Pub Date : 2020-01-24 Santosh R D'Mello
Neurodevelopment is a highly complex process composed of several carefully regulated events starting from the proliferation of neuroepithelial cells and culminating with and refining of neural networks and synaptic transmission. Improper regulation of any of these neurodevelopmental events often results in severe brain dysfunction. Accumulating evidence indicates that epigenetic modifications of chromatin
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Presence of Mother Reduces Early-Life Social Stress: Linking the Alteration in Hypothalamic-Pituitary-Adrenal Axis and Serotonergic System. Dev. Neurosci. (IF 3.041) Pub Date : 2019-12-20 Koilmani Emmanuvel Rajan,Suba Soundarya,Christopher Karen,Vasudevan Shanmugapriya,Karuppasamy Radhakrishnan
In this study, we examined whether the presence of mother suppresses early-life stressful social experience (SSE)-induced anxiety-like behavior and impairment of short-term memory later in life. On postnatal day (PND)-5, mothers with pups were grouped as follows: (i) control; (ii) maternal separation (MS); (iii) pups with mother experience the presence of a stranger (M+P-ST); and (iv) maternal separated
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Plasma Levels, Temporal Trends and Clinical Associations between Biomarkers of Inflammation and Vascular Homeostasis after Pediatric Traumatic Brain Injury. Dev. Neurosci. (IF 3.041) Pub Date : 2019-09-25 Abhijit V Lele,Bhunyawee Alunpipatthanachai,Qian Qiu,Crystalyn Clark-Bell,Arraya Watanitanon,Anne Moore,Randall M Chesnut,William Armstead,Monica S Vavilala
Expression of inflammatory (interleukin-6 [IL-6]) and vascular homeostatic (angiopoietin-2 [AP-2], endothelin-1 [ET-1], endocan-2 [EC-2]) biomarkers in pediatric traumatic brain injury (TBI) was examined in this prospective, observational cohort study of 28 children hospitalized with mild, moderate, and severe TBI by clinical measures (age, sex, Glasgow Coma Scale score [GCS], Injury Severity Score
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Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury. Dev. Neurosci. (IF 3.041) Pub Date : 2019-09-25 Shiyu Shu,Zhi Zhang,Dawn Spicer,Ewa Kulikowicz,Ke Hu,Savalan Babapoor-Farrokhran,Sujatha Kannan,Raymond C Koehler,Courtney L Robertson
The arachidonic acid pathway metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to ischemia/reperfusion brain injury. Inhibition of 20-HETE formation can protect the developing brain from global ischemia. Here, we examined whether treatment with the 20-HETE synthesis inhibitor N-hydroxy-N-4-butyl-2-methylphenylformamidine (HET0016) can protect the immature brain from traumatic brain injury
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Postnatal Expression Patterns of Estrogen Receptor Subtypes and Choline Acetyltransferase in Different Regions of the Papez Circuit. Dev. Neurosci. (IF 3.041) Pub Date : 2019-09-19 Yu-Xiang Wang,Lin Zhu,Li-Xia Li,Hui-Nan Xu,Hong-Gang Wang,Di An,Bin Heng,Qiang Zhao,Yan-Qiang Liu
The Papez circuit is crucial for several brain functions, including long-term memory and emotion. Estradiol modulates cognitive functions based on the expression pattern of its receptor subtypes including estrogen receptor (ER) α, β, and G protein-coupled receptor 30 (GPR30). Similarly, the activity in the cholinergic system correlates with several brain functions, such as learning and memory. In this
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Subcortical Volume Correlates of Psychological Distress in Early Adolescence. Dev. Neurosci. (IF 3.041) Pub Date : 2019-09-03 Kathryn M Broadhouse,Amanda Boyes,Natalie Winks,Tayla Dokonal,Larisa McLoughlin,Marcella Parker,Denise Beaudequin,Gabrielle Simcock,Jim Lagopoulos,Daniel F Hermens
The hippocampus and amygdala have justifiably been the focus of much mental health research due to their putative roles in top-down processing control of emotion, fear, and anxiety. However, understanding the causal relationship between these regions and mental illness has been limited as current literature is lacking in the observation of neuro-structural changes preceding first episodes. Here, we
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Expression Analyses of POGZ, A Responsible Gene for Neurodevelopmental Disorders, during Mouse Brain Development. Dev. Neurosci. (IF 3.041) Pub Date : 2019-08-21 Kyoko Ibaraki,Nanako Hamada,Ikuko Iwamoto,Hidenori Ito,Noriko Kawamura,Rika Morishita,Hidenori Tabata,Koh-Ichi Nagata
POGZ is a heterochromatin protein 1 α-binding protein and regulates gene expression. On the other hand, accumulating pieces of evidence indicate that the POGZ gene abnormalities are involved in various neurodevelopmental disorders. In this study, we prepared a specific antibody against POGZ, anti-POGZ, and carried out biochemical and morphological characterization with mouse brain tissues. Western
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Sex Differences and Similarities in Hippocampal Cellular Proliferation and the Number of Immature Neurons during Adolescence in Rats. Dev. Neurosci. (IF 3.041) Pub Date : 2019-08-21 Alina Siddiqui,Russell D Romeo
Adolescence is associated with significant reductions in hippocampal cellular proliferation and neurogenesis, the physiological and behavioral implications of which are unclear. Though sex differences exist in these proliferative processes in adulthood, relatively little is known about the role sex plays in these adolescent-related changes. To address this gap, we examined cross-sectional area of the
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Cellular Dynamics during Spinal Cord Regeneration in Larval Zebrafish. Dev. Neurosci. (IF 3.041) Pub Date : 2019-08-08 Consuelo Anguita-Salinas,Mario Sánchez,Rodrigo A Morales,María Laura Ceci,Diego Rojas-Benítez,Miguel L Allende
The study of spinal cord regeneration using diverse animal models, which range from null to robust regenerative capabilities, is imperative for understanding how regeneration evolved and, eventually, to treat spinal cord injury and paralysis in humans. In this study, we used electroablation to fully transect the spinal cord of zebrafish larvae (3 days postfertilization) and examined regeneration of
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Abnormal Auditory Mismatch Fields in Children and Adolescents with 47,XYY Syndrome. Dev. Neurosci. (IF 3.041) Pub Date : 2019-07-05 Junko Matsuzaki,Luke Bloy,Lisa Blaskey,Judith Miller,Emily S Kuschner,Matthew Ku,Marissa Dipiero,Megan Airey,J Christopher Edgar,David Embick,Judith L Ross,Timothy P L Roberts
47,XYY syndrome (XYY) is one of the common forms of sex chromosome aneuploidy in males. XYY males tend to have tall stature, early speech, motor delays, social and behavioral challenges, and a high rate of language impairment. Recent studies indicate that 20-40% of males with XYY meet diagnostic criteria for autism spectrum disorder (ASD; the rate in the general population is 1-2%). Although many studies
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Perinatal Ischemia Alters Global Expression of Synaptosomal Proteins Critical for Neural Plasticity in the Developing Mouse Brain. Dev. Neurosci. (IF 3.041) Pub Date : 2019-06-18 Amanda K Barks,Montana M Beeson,Tatyana Matveeva,Jonathan J Gale,Raghavendra Rao,Phu V Tran
Ischemic perinatal stroke (IPS) affects 1 in 2,300-5,000 live births. Despite a survival rate >95%, approximately 60% of IPS infants develop motor and cognitive impairments. Given the importance of axonal growth and synaptic plasticity in neurocognitive development, our objective was to identify the molecular pathways underlying IPS-associated synaptic dysfunction using a mouse model. IPS was induced
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Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects. Dev. Neurosci. (IF 3.041) Pub Date : 2019-06-18 Sarah A Jablonski,Michael T Williams,Charles V Vorhees
Methamphetamine (MA) abuse is a worldwide issue that produces health and cognitive effects in the user. MA is abused by some women who then become pregnant and expose their developing child to the drug. Preclinical rodent models demonstrate cognitive deficits following developmental MA exposure, an effect observed in children exposed to MA in utero. To determine if the dopamine receptor D1 (DRD1) is
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Rapid and Efficient Differentiation of Rodent Neural Stem Cells into Oligodendrocyte Progenitor Cells. Dev. Neurosci. (IF 3.041) Pub Date : 2019-06-06 Shen Li,Jiao Zheng,Linlin Chai,Mengsi Lin,Ruocheng Zeng,Jianhong Lu,Jing Bian
Oligodendrocyte progenitor cells (OPCs) may have beneficial effects in cell replacement therapy of neurodegenerative disease owing to their unique capability to differentiate into myelinogenic oligodendrocytes (OLs) in response to extrinsic signals. Therefore, it is of significance to establish an effective differentiation methodology to generate highly pure OPCs and OLs from some easily accessible
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Ascending Lipopolysaccharide-Induced Intrauterine Inflammation in Near-Term Rabbits Leading to Newborn Neurobehavioral Deficits. Dev. Neurosci. (IF 3.041) Pub Date : 2019-06-05 Zhongjie Shi,Jeannette Vasquez-Vivar,Kehuan Luo,Yan Yan,Frances Northington,Mohammad Mehrmohammadi,Sidhartha Tan
BACKGROUND Chorioamnionitis from ascending bacterial infection through the endocervix is a potential risk factor for cerebral palsy. Tetrahydrobiopterin, an essential cofactor for nitric oxide synthase (NOS) and amino acid hydroxylases, when augmented in the fetal brain, prevents some of the cerebral palsy-like deficits in a rabbit hypoxia-ischemia model. OBJECTIVES To study the effect of lipopolysaccharide
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Preschool Language Outcomes following Perinatal Hypoxic-Ischemic Encephalopathy in the Age of Therapeutic Hypothermia. Dev. Neurosci. (IF 3.041) Pub Date : 2019-06-05 Eric M Chin,Srishti Jayakumar,Ezequiel Ramos,Gwendolyn Gerner,Bruno P Soares,Elizabeth Cristofalo,Mary Leppert,Marilee Allen,Charla Parkinson,Michael Johnston,Frances Northington,Vera Joanna Burton
Early studies following perinatal hypoxic-ischemic encephalopathy (HIE) suggested expressive language deficits and academic difficulties, but there is only limited detailed study of language development in this population since the widespread adoption of therapeutic hypothermia (TH). Expressive and receptive language testing was performed as part of a larger battery with 45 children with a mean age
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Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-30 Charlotte Holme Nielsen,Anne Bladt Brandt,Thomas Thymann,Karina Obelitz-Ryom,Pingping Jiang,Charlotte Vanden Hole,Chris van Ginneken,Stanislava Pankratova,Per Torp Sangild
Preterm birth interrupts intrauterine brain growth and maturation and may induce a delay in postnatal neurodevelopment. Such developmental delays can result from the reduced fetal age at birth, together with the clinical compli-cations of preterm birth (e.g., hypoxia, ischemia, and inflammation). We hypothesized that late preterm birth, inducing only mild clinical complications, has minimal effects
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Neonatal Inhibition of Connexin 36 Ameliorates Fetal Brain Injury Induced by Maternal Noninfectious Fever in Mice. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-22 Ruifen Wang,Yueqing Yang,Min Xiao,Binfang Guo,Weili Liu,Haiyan Wang
Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of iNOS and COX-2 were measured as an index of neuroinflammation in the brain of newborn
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Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-22 Francesca M Notarangelo,Sarah Beggiato,Robert Schwarcz
Several lines of evidence support the hypothesis that abnormally elevated brain levels of kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan degradation, play a pathophysiologically significant role in schizophrenia and other major neurodevelopmental disorders. Studies in experimental animal models suggest that KP impairments in these diseases may originate already in
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Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-21 Caitlin E O'Brien,Polan T Santos,Ewa Kulikowicz,Michael Reyes,Raymond C Koehler,Lee J Martin,Jennifer K Lee
Therapeutic hypothermia is the standard of clinical care for moderate neonatal hypoxic-ischemic encephalopathy. We investigated the independent and interactive effects of hypoxia-ischemia (HI) and temperature on neuronal survival and injury in basal ganglia and cerebral cortex in neonatal piglets. Male piglets were randomized to receive HI injury or sham procedure followed by 29 h of normothermia,
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Exogenous Ketone Bodies as Promising Neuroprotective Agents for Developmental Brain Injury. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-16 Thomas R Wood,Brianna J Stubbs,Sandra E Juul
Ketone bodies are a promising area of neuroprotection research that may be ideally suited to the injured newborn. During normal development, the human infant is in significant ketosis for at least the first week of life. Ketone uptake and metabolism is upregulated in the both the fetus and neonate, with ketone bodies providing at least 10% of cerebral metabolic energy requirements, as well as being
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A Ferret Model of Encephalopathy of Prematurity. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-10 Thomas Wood,Daniel Moralejo,Kylie Corry,Jessica M Snyder,Christopher Traudt,Chad Curtis,Elizabeth Nance,Pratik Parikh,Sandra E Juul
There is an ongoing need for relevant animal models in which to test therapeutic interventions for infants with neurological sequelae of prematurity. The ferret is an attractive model species as it has a gyrified brain with a white-to-gray matter ratio similar to that in the human brain. A model of encephalopathy of prematurity was developed in postnatal day 10 (P10) ferret kits, considered to be developmentally
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Comparison of Frequency- and Time-Domain Autoregulation and Vasoreactivity Indices in a Piglet Model of Hypoxia-Ischemia and Hypothermia. Dev. Neurosci. (IF 3.041) Pub Date : 2019-05-02 Rathinaswamy B Govindan,Ken M Brady,An N Massaro,Jamie Perin,Jacky M Jennings,Adre J DuPlessis,Raymond C Koehler,Jennifer K Lee
INTRODUCTION The optimal method to detect impairments in cerebrovascular pressure autoregulation in neonates with hypoxic-ischemic encephalopathy (HIE) is unclear. Improving autoregulation monitoring methods would significantly advance neonatal neurocritical care. METHODS We tested several mathematical algorithms from the frequency and time domains in a piglet model of HIE, hypothermia, and hypotension
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Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats. Dev. Neurosci. (IF 3.041) Pub Date : 2019-04-19 Marcelo Volpon Santos,Luiza da Silva Lopes,Hélio Rubens Machado,Ricardo Santos de Oliveira
INTRODUCTION Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment. OBJECTIVES To analyze the clinical, radiological, histopathological, and
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The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia. Dev. Neurosci. (IF 3.041) Pub Date : 2019-04-18 Jana Krystofova,Praneeti Pathipati,Jeffrey Russ,Ann Sheldon,Donna Ferriero
Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular
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Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study. Dev. Neurosci. (IF 3.041) Pub Date : 2019-04-18 Shiyu Tang,Su Xu,Jaylyn Waddell,Wenjun Zhu,Rao P Gullapalli,Sandra M Mooney
Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic
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Assessing Cerebral Metabolism in the Immature Rodent: From Extracts to Real-Time Assessments. Dev. Neurosci. (IF 3.041) Pub Date : 2019-04-17 Alkisti Mikrogeorgiou,Duan Xu,Donna M Ferriero,Susan J Vannucci
Brain development is an energy-expensive process. Although glucose is irreplaceable, the developing brain utilizes a variety of substrates such as lactate and the ketone bodies, β-hydroxybutyrate and acetoacetate, to produce energy and synthesize the structural components necessary for cerebral maturation. When oxygen and nutrient supplies to the brain are restricted, as in neonatal hypoxia-ischemia
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How Early Can a Seizure Happen? Pathophysiological Considerations of Extremely Premature Infant Brain Development. Dev. Neurosci. (IF 3.041) Pub Date : 2019-04-05 Melisa Carrasco,Carl E Stafstrom
Seizures in neonates represent a neurologic emergency requiring prompt recognition, determination of etiology, and treatment. Yet, the definition and identification of neonatal seizures remain challenging and controversial, in part due to the unique physiology of brain development at this life stage. These issues are compounded when considering seizures in premature infants, in whom the complexities
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Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-28 Tracylyn R Yellowhair,Shahani Noor,Brittney Mares,Clement Jose,Jessie C Newville,Jessie R Maxwell,Frances J Northington,Erin D Milligan,Shenandoah Robinson,Lauren L Jantzie
Preterm birth is an important cause of perinatal brain injury (PBI). Neurological injury in extremely preterm infants often begins in utero with chorioamnionitis (CHORIO) or inflammation/infection of the placenta and concomitant placental insufficiency. Studies in humans have shown dysregulated inflammatory signaling throughout the placental-fetal brain axis and altered peripheral immune responses
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Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-25 Daria S Kalinina,Dmitrii S Vasilev,Anna B Volnova,Natalia N Nalivaeva,Igor A Zhuravin
Using electrocorticogram (ECoG) analysis, we compared age-related dynamics of general neuronal activity and convulsive epileptiform responsiveness induced by intracortical microinjections of 4-aminopyridine (4-AP) in control Wistar rats and those subjected to prenatal hypoxia (Hx; E14; 7% O2, 3 h). The studies were carried out in three age periods roughly corresponding to childhood (P20-27), adolescence
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Golgipathies in Neurodevelopment: A New View of Old Defects. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-18 Sowmyalakshmi Rasika,Sandrine Passemard,Alain Verloes,Pierre Gressens,Vincent El Ghouzzi
The Golgi apparatus (GA) is involved in a whole spectrum of activities, from lipid biosynthesis and membrane secretion to the posttranslational processing and trafficking of most proteins, the control of mitosis, cell polarity, migration and morphogenesis, and diverse processes such as apoptosis, autophagy, and the stress response. In keeping with its versatility, mutations in GA proteins lead to a
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Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-13 Andra L Dingman,Krista M Rodgers,Robert M Dietz,Sean P Hickey,Alexandra P Frazier,Amy C Clevenger,Joan C Yonchek,Richard J Traystman,Wendy B Macklin,Paco S Herson
The incidence of stroke in children is 2.4 per 100,000 person-years and results in long-term motor and cognitive disability. In ischemic stroke, white matter (WM) is frequently injured, but is relatively understudied compared to grey matter injury. Previous research suggests that the cellular response to WM ischemic injury is different at different ages. Little is known about whether WM repair mechanisms
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Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-12 Janasha Goffigan-Holmes,Dafne Sanabria,Johana Diaz,Debra Flock,Raul Chavez-Valdez
Hippocampal injury following neonatal hypoxia-ischemia (HI) leads to memory impairments despite therapeutic hypothermia (TH). In the hippocampus, the expression of calbindin-1 (Calb1), a Ca2+-buffering protein, increases during postnatal development and decreases with aging and neurodegenerative disorders. Since persistent Ca2+ dysregulation after HI may lead to ongoing injury, persistent changes in
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The Effect of Antenatal Betamethasone on White Matter Inflammation and Injury in Fetal Sheep and Ventilated Preterm Lambs. Dev. Neurosci. (IF 3.041) Pub Date : 2019-03-07 Vanesa Stojanovska,Samantha K Barton,Mary Tolcos,Andrew W Gill,Martin Kluckow,Suzanne L Miller,Valerie Zahra,Stuart B Hooper,Robert Galinsky,Graeme R Polglase
Antenatal administration of betamethasone (BM) is a common antecedent of preterm birth, but there is limited information about its impact on the acute evolution of preterm neonatal brain injury. We aimed to compare the effects of maternal BM in combination with mechanical ventilation on the white matter (WM) of late preterm sheep. At 0.85 of gestation, pregnant ewes were randomly assigned to receive
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