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Identifying the Neurodevelopmental Differences of Opioid Withdrawal Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-12 Nynke J. van den Hoogen, Charlie H. T. Kwok, Tuan Trang
Stopping opioid medications can result in a debilitating withdrawal syndrome in chronic users. Opioid withdrawal can occur at all ages, but mechanistic understanding of this condition is predominantly derived from adult studies. Here, we examined whether there are age-dependent differences in the behavioural phenotype and cellular indices of opioid withdrawal. We tested this by assessing the behavioural
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Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-12 Lisa L. Wilson, Soumen Chakraborty, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Chloe A. Simons, Rajendra Uprety, Susruta Majumdar, Jay P. McLaughlin
Chronic administration of opioids produces physical dependence and opioid-induced hyperalgesia. Users claim the Thai traditional tea “kratom” and component alkaloid mitragynine ameliorate opioid withdrawal without increased sensitivity to pain. Testing these claims, we assessed the combined kratom alkaloid extract (KAE) and two individual alkaloids, mitragynine (MG) and the analog mitragynine pseudoindoxyl
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Sarm1 is Essential for Anesthesia-Induced Neuroinflammation and Cognitive Impairment in Aged Mice Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-12 Huimei Lin, Zhenming Kang, Shunyuan Li, Jingyang Zeng, Jie Zhao
Postoperative cognitive dysfunction (POCD) is a common phenomenon among elderly patients with unclear etiology. Sterile alpha and TIR motif-containing 1 (Sarm1) plays important roles in neuroinflammation and cognitive function, and activates Calpain which has been shown to promote POCD through TrkB cleavage. This study aims to test the hypothesis that Sarm1 is involved in POCD through regulating Calpain
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Sidestream Smoke Affects Dendritic Complexity and Astrocytes After Model Mild Closed Head Traumatic Brain Injury Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-08 Whitney A. Ratliff, Jessica N. Saykally, Kristen L. Keeley, David C. Driscoll, Kathleen E. Murray, Maja Okuka, Ronald F. Mervis, Vedad Delic, Bruce A. Citron
Mild traumatic brain injuries can have long-term consequences that interfere with the life of the patient and impose a burden on our health care system. Oxidative stress has been identified as a contributing factor for the progression of neurodegeneration following TBI. A major source of oxidative stress for many veterans is cigarette smoking and second-hand smoke, which has been shown to have an effect
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SHARPIN: Role in Finding NEMO and in Amyloid-Beta Clearance and Degradation (ABCD) Pathway in Alzheimer’s Disease? Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-05 Dhanya Krishnan, Ramsekhar N. Menon, Srinivas Gopala
SHANK- associated RH domain-interacting protein (SHARPIN) is a multifunctional protein associated with numerous physiological functions and many diseases. The primary role of the protein as a LUBAC-dependent component in regulating the activation of the transcription factor NF-κB accounts to its role in inflammation and antiapoptosis. Hence, an alteration of SHARPIN expression or genetic mutations
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Aversive Stress Reduces Mu Opioid Receptor Expression in the Intercalated Nuclei of the Rat Amygdala Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-05 Shawn Gouty, Julia Tomoyasu Silveira, Thomas E. Cote, Brian M. Cox
The amygdala plays an important role in the integration of responses to noxious and fearful stimuli. Sensory information from many systems is integrated in the lateral and basolateral amygdala and transmitted to the central amygdala, the major output nucleus of the amygdala regulating both motor and emotional responses. The network of intercalated cells (ITC) which surrounds the lateral and basolateral
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Dysbiosis and Alzheimer’s Disease: Cause or Treatment Opportunity? Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-05 Manuel H. Janeiro, María J. Ramírez, Maite Solas
Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and human health. An imbalance of the intestinal bacteria representation (dysbiosis) could lead to different diseases, ranging from obesity and diabetes, to neurological disorders including Alzheimer’s disease (AD). The term “gut-brain axis” refers to a crosstalk between
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Concurrent Akt, ERK1/2 and AMPK Activation by Obestatin Inhibits Apoptotic Signaling Cascades on Nutrient-Deprived PC12 Cells Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-05 Agustín Sánchez-Temprano, José Luis Relova, Jesús P. Camiña, Yolanda Pazos
Targeting apoptosis in the ischemic penumbra is a rational therapeutic approach for restricting cerebral infarct volume after clinical stroke. The present work explored the capability of the obestatin peptide, as a novel approach to inhibit apoptotic signaling cascades on PC12 cells. According to the results, obestatin treatment significantly reduced nutrient deprivation-induced apoptotic cell death
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Distinct Effects of BDNF and NT-3 on the Dendrites and Presynaptic Boutons of Developing Olfactory Bulb GABAergic Interneurons In Vitro Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-04 Vanesa Nieto-Estévez, Çağla Defterali, Carlos Vicario
Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) are known to regulate neuronal morphology and the formation of neural circuits, yet the neuronal targets of each neurotrophin are still to be defined. To address how these neurotrophins regulate the morphological and synaptic differentiation of developing olfactory bulb (OB) GABAergic interneurons, we analyzed the effect of BDNF and
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Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer’s Type Neurodegeneration Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-04 Yulia K. Komleva, O. L. Lopatina, Ya V. Gorina, A. I. Chernykh, L. V. Trufanova, E. F. Vais, E. V. Kharitonova, E. L. Zhukov, L. Yu Vahtina, N. N. Medvedeva, A. B. Salmina
A common feature of neurodegenerative disorders, in particular Alzheimer's disease (AD), is a chronic neuroinflammation associated with aberrant neuroplasticity. Development of neuroinflammation affects efficacy of stem and progenitor cells proliferation, differentiation, migration, and integration of newborn cells into neural circuitry. However, precise mechanisms of neurogenesis alterations in neuroinflammation
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Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-03 Hui Cao, Sai Wang Seto, Deep Jyoti Bhuyan, Hoi Huen Chan, Wenting Song
Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased permeability of the blood–brain barrier (BBB), followed
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Prostaglandin E2 Increases Neurite Length and the Formation of Axonal Loops, and Regulates Cone Turning in Differentiating NE4C Cells Via PKA Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-03 Ashby Kissoondoyal, Dorota A. Crawford
Prostaglandin E2 (PGE2) is a membrane-derived lipid signaling molecule important in neuronal development. Abnormal levels of PGE2, due to environmental insults prenatal development, have been linked to brain pathologies. We have previously shown that the addition of PGE2 to neuroectodermal (NE4C) stem cells affects early stages of neuronal differentiation (day 0–8) including increased stem cell motility
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GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-03 Abdalla M. Albeely, Olivia O. F. Williams, Melissa L. Perreault
Alterations in glycogen synthase kinase-3β (GSK-3β) activity have been implicated in disorders of cognitive impairment, including Alzheimer’s disease and schizophrenia. Cognitive dysfunction is also characterized by the dysregulation of neuronal oscillatory activity, macroscopic electrical rhythms in brain that are critical to systems communication. A direct functional relationship between GSK-3β and
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Procalcitonin related to stroke-associated pneumonia and clinical outcomes of acute ischemic stroke after IV rt-PA treatment Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-02 Guomei Shi, Minghao Li, Rujuan Zhou, Xiaorong Wang, Wu Xu, Feng Yang, Shouru Xue
To investigate the possible relationship between procalcitonin (PCT) and stroke-associated pneumonia (SAP) as well as clinical outcomes after recombinant tissue plasminogen activator (rt-PA) treatment of AIS. From June 2015 to December 2019, 173 consecutive patients with AIS after IV rt-PA treatment were prospectively enrolled. Serum PCT concentrations were measured after admission. Multivariate logistic
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Chronic Pain Causes Peripheral and Central Responses in MIA-Induced TMJOA Rats Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-02 Henghua Jiang, Liqin Xu, Wen Liu, Mian Xiao, Jin Ke, Xing Long
Chronic pain is the predominant symptom that drives temporomandibular joint osteoarthritis (TMJOA) patients to seek medical care; however, currently used treatment modalities remain less effective. This study aimed to investigate chronic pain and the peripheral and central responses in monoiodoacetate (MIA)-induced TMJOA rats. First, the appropriate dose of MIA was determined based on pain behavior
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Regulation of Opioid Receptors by Their Endogenous Opioid Peptides Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-02 Achla Gupta, Srinivas Gullapalli, Hui Pan, Dinah L. Ramos-Ortolaza, Michael D. Hayward, Malcom J. Low, John E. Pintar, Lakshmi A. Devi, Ivone Gomes
Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin. Using a knockout approach, we sought to determine whether the absence
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Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2021-01-02 Fillipe M. de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L. Costa, Victor Diogenes A. Silva, Maria Trinidad Herrero
Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the Substantia Nigra pars compacta (SNpc) and deficit of dopamine in the basal ganglia. These motor symptoms can be preceded by pre-motor symptoms whose recognition can be useful to apply different
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MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-12-24 Rais Reskiawan A. Kadir, Mansour Alwjwaj, Ulvi Bayraktutan
Stroke continues to be the third-leading cause of death and disability worldwide. The limited availability of diagnostic tools approved therapeutics and biomarkers that help monitor disease progression or predict future events remain as the major challenges in the field of stroke medicine. Hence, attempts to discover safe and efficacious therapeutics and reliable biomarkers are of paramount importance
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The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-12-10 Mayukha Bathini, Chandavalli Ramappa Raghushaker, Krishna Kishore Mahato
Neurodegenerative diseases might be slow but relentless, as we continue to fail in treating or delaying their progression. Given the complexity in the pathogenesis of these diseases, a broad-acting approach like photobiomodulation can prove promising. Photobiomodulation (PBM) uses red and infrared light for therapeutic benefits, working by stimulating growth and proliferation. The implications of photobiomodulation
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Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-12-01 Maria Serena Paladini, Davide Marangon, Andrea C. Rossetti, Alice Guidi, Giusy T. Coppolino, Camilla Negri, Vittoria Spero, Maria Pia Abbracchio, Davide Lecca, Raffaella Molteni
One of the most substantial and established environmental risk factors for neurological and psychiatric disorders is stress exposure, whose detrimental consequences hinge on several variables including time. In this regard the gestational period is known to present an intrinsic vulnerability to environmental insults and thus stressful events during pregnancy can lead to severe consequences on the offspring’s
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Role of Altered Expression, Activity and Sub-cellular Distribution of Various Histone Deacetylases (HDACs) in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-28 Arpna Srivastava, Jyotirmoy Banerjee, Vivek Dubey, Manjari Tripathi, P. Sarat Chandra, M. C. Sharma, Sanjeev Lalwani, Fouzia Siraj, Ramesh Doddamani, Aparna Banerjee Dixit
Histone deacetylases (HDACs) have been described to have both neurotoxic and neuroprotective roles, and partly, depend on its sub-cellular distribution. HDAC inhibitors have a long history of use in the treatment of various neurological disorders including epilepsy. Key role of HDACs in GABAergic neurotransmission, synaptogenesis, synaptic plasticity and memory formation was demonstrated whereas very
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If Artificial In Vitro Microenvironment Can Influence Tumor Drug Resistance Network via Modulation of lncRNA Expression?—Comparative Analysis of Glioblastoma-Derived Cell Culture Models and Initial Tumors In Vivo Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-27 Monika Witusik-Perkowska, Dariusz J. Jaskólski, Paweł P. Liberski, Janusz Szemraj
The tumor resistance of glioblastoma cells in vivo is thought to be enhanced by their heterogeneity and plasticity, which are extremely difficult to curb in vitro. The external microenvironment shapes the molecular profile of tumor culture models, thus influencing potential therapy response. Our study examines the expression profile of selected lncRNAs involved in tumor resistance network in three
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Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-27 Cherkaouia Kibaly, Jacob A. Alderete, Steven H. Liu, Hazem S. Nasef, Ping-Yee Law, Christopher J. Evans, Catherine M. Cahill
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis
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Curcumin Improves Human Umbilical Cord-Derived Mesenchymal Stem Cell Survival via ERK1/2 Signaling and Promotes Motor Outcomes After Spinal Cord Injury Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-27 Wu Wanjiang, Chen Xin, Chen Yaxing, Wang Jie, Zhang Hongyan, Ni Fei, Ling Chengmin, Feng Chengjian, Yuan Jichao, Lin Jiangkai
Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation is thought to be a promising strategy for treating spinal cord injury (SCI). However, the low survival rate of transplanted hUC-MSCs limits their clinical application in cell replacement therapy. Curcumin can suppress inflammation after SCI; however, it remains unknown whether curcumin can modulate the survival of transplanted
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Supporting Evidence of Human Enteric Nervous System Adult Neurogenesis: Presence of Primary Cilia and Adult Neurogenesis Markers Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-25 Pablo Iruzubieta, Irene Cantarero, Marta Monzón, Manuel Lahoz, Concepción Junquera
Adult neurogenesis has been profusely studied in central nervous system. However, its presence in enteric nervous system remains elusive although it has been recently demonstrated in mice and intimately linked to glial cells. Moreover, primary cilium is an important organelle in central adult neurogenesis. In the present study, we analysed some parallelisms between central and enteric nervous system
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Non-visual Opsins and Novel Photo-Detectors in the Vertebrate Inner Retina Mediate Light Responses Within the Blue Spectrum Region Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-24 Mario E. Guido, Natalia A. Marchese, Maximiliano N. Rios, Luis P. Morera, Nicolás M. Diaz, Eduardo Garbarino-Pico, María Ana Contin
In recent decades, a number of novel non-visual opsin photopigments belonging to the family of G protein- coupled receptors, likely involved in a number of non-image-forming processes, have been identified and characterized in cells of the inner retina of vertebrates. It is now known that the vertebrate retina is composed of visual photoreceptor cones and rods responsible for diurnal/color and nocturnal/black
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Nerve Growth Factor is a Potential Treated Target in Tg(SOD1*G93A)1Gur Mice Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-24 Zhenzhen Xu, Jianxiang Jiang, Shengyuan Xu, Zunchun Xie, Pei He, Shishi Jiang, Renshi Xu
Nerve growth factor (NGF) is a protective factor of neural cells; the possible relationship between the NGF and the pathogenesis of amyotrophic lateral sclerosis (ALS) hasn’t been completely known. In this study, we observed and analyzed the expression and distribution of NGF, as well as the possible relationship between the NGF expression and distribution and the neural cell death in both SOD1 wild-type
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Targeting Caveolin-1 and Claudin-5 with AY9944, Improve Blood–Brain Barrier Permeability; Computational Simulation and Experimental Study Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-21 Leila Gholami, Safura Jokar, Yousef Fatahi, Hedayat Samandari, Javad Hamzehalipour Almaki, Marjan Hosseini, Mohsen Parviz
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Neuroprotective Effect of 2-Aminoethoxydiphenyl Borate (2-APB) in Amyloid β-Induced Memory Dysfunction: A Mechanistic Study Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-21 Pavan Thapak, Pragyanshu Khare, Mahendra Bishnoi, Shyam Sunder Sharma
β-Amyloid (Aβ) peptide is a characteristic feature of Alzheimer’s disease (AD) and accumulation of Aβ is associated with loss of synaptic plasticity and neuronal cell death. Aggregation of Aβ initiates numerous molecular signalling pathways leading to oxidative stress, mitochondrial dysfunction as well as an imbalance of calcium ion influx homeostasis. Recently, it has been shown that transient receptor
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Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-21 Sanjiv Singh, Upendr Gautam, F. V. Manvi
Extensive applications of ZnO NPs (zinc oxide nanoparticles) in daily life have created concern about their biotoxicity. Zinc oxide nanoparticles induce oxidative stress, inflammation, and apoptosis in neurons. Edaravone applies antioxidant agent and anti-inflammatory impacts in the different cells, as evaluated in both in vitro and in vivo experimental models. This study is designed to explore, how
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Purinergic Receptors Crosstalk with CCR5 to Amplify Ca 2+ Signaling Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-20 Mizuho Horioka, Emilie Ceraudo, Emily Lorenzen, Thomas P. Sakmar, Thomas Huber
Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency virus 1 (HIV-1), normally signals through the heterotrimeric G protein, Gi. However, CCR5 also exhibits G protein signaling bias and certain chemokine analogs
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Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-19 Jianbin Guo, Guoqing Yang, Yuqing He, Huiming Xu, Hong Fan, Jing An, Lingling Zhang, Rui Zhang, Guihua Cao, Dingjun Hao, Hao Yang
Abnormal excessive production and deposition of β-amyloid (Aβ) peptides in selectively susceptible brain regions are thought to be a key pathogenic mechanism underlying Alzheimer’s disease (AD), resulting in memory deficits and cognitive impairment. Genistein is a phytoestrogen with great promise for counteracting diverse Aβ-induced insults, including oxidative stress and mitochondrial dysfunction
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Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-18 Sowmithra Sowmithra, Nishtha Kusum Jain, Ramesh Bhonde, Indrani Datta
Increasing evidence suggests that mesenchymal stem cells(MSCs) have beneficial effects in hypoxic ischemic reperfusion injury, but the underlying mechanisms are unclear. Here, we first examined the effect of OGD reperfusion injury on the vulnerability of human NPs derived from human embryonic stem cells (hESCs) with regard to cell survival and oxidative stress. Cellular deregulation was assessed by
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Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-18 Saloni Rahi, Sidharth Mehan
Autism is a multifactorial neurodevelopmental condition; it demonstrates some main characteristics, such as impaired social relationships and increased repetitive behavior. The initiation of autism spectrum disorder is mostly triggered during brain development by the deregulation of signaling pathways. Sonic hedgehog (SHH) signaling is one such mechanism that influences neurogenesis and neural processes
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Correction to: Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-17 Marjo Piltonen, Andrey Krokhotin, Marc Parisien, Pierre Bérubé, Haig Djambazian, Rob Sladek, Nikolay V. Dokholyan, Svetlana A. Shabalina, Luda Diatchenko
The article “Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants”, written by Marjo Piltonen, Andrey Krokhotin, Marc Parisien, Pierre Bérubé, Haig Djambazian, Rob Sladek, Nikolay V. Dokholyan, Svetlana A. Shabalina and Luda Diatchenko was originally published electronically on the publisher’s internet portal on October 3, 2020 without open access. With
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Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-17 Baojian Xue, Jiarui Xue, Yang Yu, Shun-Guang Wei, Terry G. Beltz, Robert B. Felder, Alan Kim Johnson
Post-traumatic stress disorder (PTSD), an anxiety-related syndrome, is associated with increased risk for cardiovascular diseases. The present study investigated whether predator scent (PS) stress, a model of PTSD, induces sensitization of hypertension and anxiety-like behaviors and underlying mechanisms related to renin–angiotensin systems (RAS) and inflammation. Coyote urine, as a PS stressor, was
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Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2 Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-17 Fariba Khodagholi, Ali Maleki, Fereshteh Motamedi, Maryam Alsadat Mousavi, Shahrbanoo Rafiei, Mehdi Moslemi
Huntington disease (HD) is a progressive neurological disorder with dominant motor symptoms. It also has psychiatric manifestations, like anxiety and depression, that can emerge themselves before motor symptoms and impose a major burden on patients. Oxytocin (OXT) is a newly emerged treatment for disorders like autism and schizophrenia and recently is using to alleviate depression and anxiety. In the
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p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-17 Mingming Chen, Linlu Guo, Jie Hao, Jie Ni, Qunyu Lv, Xiaoyan Xin, Hong Liao
Astrogliosis after brain trauma can have a significant impact on functional recovery. However, little is known about the mechanisms underlying astrocyte proliferation and subsequent astrogliosis. In this study, we established a cortical stab wound injury mouse model and observed dramatic astrocyte activation and nerve growth factor receptor (p75NTR) upregulation near the lesion. We also found profound
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Mitochondria-ER Tethering in Neurodegenerative Diseases Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-16 Reza Raeisossadati, Merari F. R. Ferrari
Organelles juxtaposition has been detected for decades, although only recently gained importance due to a pivotal role in the regulation of cellular processes dependent on membrane contact sites. Endoplasmic reticulum (ER) and mitochondria interaction is a prime example of organelles contact sites. Mitochondria-associated membranes (MAM) are proposed to harbor ER-mitochondria tether complexes, mainly
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The Opioid Interactions of the Antipsychotic Medications Risperidone and Amisulpride in Mice and Their Potential Use in the Treatment of Other Non-Psychotic Medical Conditions Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-13 Shaul Schreiber, Chaim G. Pick
Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The opioid epidemic in the USA has highlighted the need for alternative treatments for pain. Following reports on the opioid interactions of various antipsychotic medications, we speculated that the involvement of the opioid system in some of the antipsychotics’ mechanism of action may
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Remote and Persistent Alterations in Glutamate Receptor Subunit Composition Induced by Spreading Depolarizations in Rat Brain Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-12 Kinsey A. Barhorst, Yara Alfawares, Jennifer L. McGuire, Steve C. Danzer, Jed A. Hartings, Laura B. Ngwenya
Spreading depolarizations (SDs) are massive breakdowns of ion homeostasis in the brain’s gray matter and are a necessary pathologic mechanism for lesion development in various injury models. However, injury-induced SDs also propagate into remote, healthy tissue where they do not cause cell death, yet their functional long-term effects are unknown. Here we induced SDs in uninjured cortex and hippocampus
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Systematic Analysis of Protein–Protein and Gene–Environment Interactions to Decipher the Cognitive Mechanisms of Autism Spectrum Disorder Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-09 Masoumeh Farahani, Mostafa Rezaei-Tavirani, Alireza Zali, Mona Zamanian-Azodi
Autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder resulting from both genetic and environmental risk factors, is manifested by deficits in cognitive function. Elucidating the cognitive disorder-relevant biological mechanisms may open up promising therapeutic approaches. In this work, we mined ASD cognitive phenotype proteins to construct and analyze protein–protein and gene–environment
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LncRNA H19 Promotes Cell Proliferation, Migration, and Angiogenesis of Glioma by Regulating Wnt5a/β-Catenin Pathway via Targeting miR-342 Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-07 Qin Zhou, Zheng-Zheng Liu, Heng Wu, Wei-Lu Kuang
Glioma is the most common malignant brain tumor and long non-coding RNAs (lncRNAs) have been reported to play an important role in the growth and angiogenesis of glioma. However, the potential mechanisms of lncRNA H19 in glioma remain unclear. In the present study, the effects of lncRNA H19 on glioma cell proliferation, migration, and angiogenesis were evaluated. The expression levels of H19, miR-342
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Ischemic Postconditioning Reduces NMDA Receptor Currents Through the Opening of the Mitochondrial Permeability Transition Pore and K ATP Channel in Mouse Neurons Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-07 Yudai Morisaki, Ichiro Nakagawa, Yoichi Ogawa, Shohei Yokoyama, Takanori Furuta, Yasuhiko Saito, Hiroyuki Nakase
Ischemic postconditioning (PostC) is known to reduce cerebral ischemia/reperfusion (I/R) injury; however, whether the opening of mitochondrial ATP-dependent potassium (mito-KATP) channels and mitochondrial permeability transition pore (mPTP) cause the depolarization of the mitochondrial membrane that remains unknown. We examined the involvement of the mito-KATP channel and the mPTP in the PostC mechanism
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Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-06 Nan Meng, Yanhong Dong, Tiantian Huo, Meiyi Song, Xin Jiang, Yining Xiao, Peiyuan Lv
Smoking is a risk factor for dementia. Cognitive function can be partially restored after quitting smoking, but still lower than never smoked group. The underlying mechanisms still remain unclear. The effects of smoking cessation combined with cerebral chronic hypoperfusion (CCH) on cognitive function have never been described. Here, we established a cigarette smoking cessation model, a CCH model,
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Epidermal Growth Factor in the CNS: A Beguiling Journey from Integrated Cell Biology to Multiple Sclerosis. An Extensive Translational Overview Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-05 Giuseppe Scalabrino
This article reviews the wealth of papers dealing with the different effects of epidermal growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs). EGF induces the in vitro and in vivo proliferation of NSCs, their migration, and their differentiation towards the neuroglial cell line. It interacts with extracellular matrix components. NSCs are distributed in different
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Exploration of Pericyte-Derived Factors Implicated in Lung Cancer Brain Metastasis Protection: A Pilot Messenger RNA Sequencing Using the Blood–Brain Barrier In Vitro Model Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-02 Kenta Ujifuku, Takashi Fujimoto, Kei Sato, Yoichi Morofuji, Hideki Muto, Hiroshi Masumoto, Shinsuke Nakagawa, Masami Niwa, Takayuki Matsuo
Metastatic brain tumors have poor prognoses and pose unmet clinical problems for the patients. The blood–brain barrier (BBB) implication is supposed to play a major role in brain metastasis. However, the role of pericytes remains to be elucidated in the brain metastasis. This pilot study described the expression profile of interactions between pericytes, endothelial cells, and cancer cells. We applied
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High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-11-02 Jaclyn Iannucci, Haripriya Vittal Rao, Paula Grammas
Diabetes is strongly linked to the development of Alzheimer’s disease (AD), though the mechanisms for this enhanced risk are unclear. Because vascular inflammation is a consistent feature of both diabetes and AD, the cerebral microcirculation could be a key target for the effects of diabetes in the brain. The goal of this study is to explore whether brain endothelial cells, injured by diabetes-related
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Correction to: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1 Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-31 Ankita Narayan, Amanda Hunkele, Jin Xu, Daniel L. Bassoni, Gavril W. Pasternak, Ying-Xian Pan
The original version of this article unfortunately contained a typo in co-author name.
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Extracellular Matrix in Neural Plasticity and Regeneration Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-31 Yurii A. Chelyshev, Ilyas M. Kabdesh, Yana O. Mukhamedshina
The extracellular matrix (ECM) is a fundamental component of biological tissues. The ECM in the central nervous system (CNS) is unique in both composition and function. Functions such as learning, memory, synaptogenesis, and plasticity are regulated by numerous ECM molecules. The neural ECM acts as a non-specific physical barrier that modulates neuronal plasticity and axon regeneration. There are two
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Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment in Acute Ischemic Stroke Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-30 Chengli Liu, Jie Xie, Shanshan Sun, Hui Li, Tianyu Li, Chao Jiang, Xuemei Chen, Junmin Wang, Anh Le, Jiarui Wang, Zhanfei Li, Jian Wang, Wei Wang
Hemorrhagic transformation (HT) is a common complication after thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article, recent research progress of HT in vivo and in vitro studies was reviewed. We have discussed new potential mechanisms and possible experimental models of HT development, as well as possible biomarkers and treatment methods. Meanwhile
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A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington’s Disease: Possible Sex-Dependent Signaling Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-27 Akanksha Baharani, Zelan Wei, William J. Roesler, Darrell D. Mousseau
The R6/2 transgenic mouse model of Huntington’s disease (HD) carries several copies of exon1 of the huntingtin gene that contains a highly pathogenic 120 CAG-repeat expansion. We used kinome analysis to screen for kinase activity patterns in neural tissues from wildtype (WT) and R6/2 mice at a pre-symptomatic (e.g., embryonic) and symptomatic (e.g., between 3 and 10 weeks postnatal) time points. We
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Knocking Out Sigma-1 Receptors Reveals Diverse Health Problems Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-23 Simon Couly, Nino Goguadze, Yuko Yasui, Yuriko Kimura, Shao-Ming Wang, Nino Sharikadze, Hsiang-En Wu, Tsung-Ping Su
Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain, lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the endoplasmic reticulum and more specifically at the mitochondria-associated membranes. Despite numerous studies showing that Sig-1R could be targeted to rescue several cellular mechanisms in different pathological conditions, less is known about
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Context-Dependent Role of miR-124 in Retinoic Acid-Induced Growth Cone Attraction of Regenerating Motorneurons Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-23 Sarah E. Walker, Adriano Senatore, Robert L. Carlone, Gaynor E. Spencer
During development and regeneration, growth cones at the tips of extending axons navigate through a complex environment to establish accurate connections with appropriate targets. Growth cones can respond rapidly to classical and non-classical guidance cues in their environment, often requiring local protein synthesis. In vertebrate growth cones, local protein synthesis in response to classical cues
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Sulforaphane Induces Glioprotection After LPS Challenge Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-20 Larissa Daniele Bobermin, Fernanda Becker Weber, Tiago Marcon dos Santos, Adriane Belló-Klein, Angela T. S. Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santos
Sulforaphane is a natural compound that presents anti-inflammatory and antioxidant properties, including in the central nervous system (CNS). Astroglial cells are involved in several functions to maintain brain homeostasis, actively participating in the inflammatory response and antioxidant defense systems. We, herein, investigated the potential mechanisms involved in the glioprotective effects of
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Epigenetic Changes and Its Intervention in Age-Related Neurodegenerative Diseases Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-19 Nuraqila Mohd Murshid, Faridah Aminullah Lubis, Suzana Makpol
Epigenetic mechanisms involving the modulation of gene activity without modifying the DNA bases are reported to have lifelong effects on mature neurons in addition to their impact on synaptic plasticity and cognition. Histone methylation and acetylation are involved in synchronizing gene expression and protein function in neuronal cells. Studies have demonstrated in experimental models of neurodegenerative
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Histamine H 3 Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at Ca V 2.1 (P/Q-Type) Calcium Channels and GIRK (K IR 3) Potassium Channels Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-17 Héctor Vázquez-Vázquez, Carolina Gonzalez-Sandoval, Ana V. Vega, José-Antonio Arias-Montaño, Jaime Barral
The striatum is innervated by histaminergic fibers and expresses a high density of histamine H3 receptors (H3Rs), present on medium spiny neurons (MSNs) and corticostriatal afferents. In this study, in sagittal slices from the rat dorsal striatum, excitatory postsynaptic potentials (EPSPs) were recorded in MSNs after electrical stimulation of corticostriatal axons. The effect of H3R activation and
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Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-15 Hui-Ling Tang, Si-Yu Chen, Huan Zhang, Ping Lu, Wei-Wen Sun, Mei-Mei Gao, Xiang-Da Zeng, Tao Su, Yue-Sheng Long
Arachidonic acid (AA), a polyunsaturated fatty acid, is involved in the modulation of neuronal excitability in the brain. Arachidonate lipoxygenase 3 (ALOXE3), a critical enzyme in the AA metabolic pathway, catalyzes the derivate of AA into hepoxilins. However, the expression pattern of ALOXE3 and its role in the brain has not been described until now. Here we showed that the levels of Aloxe3 mRNA
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Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma Cell. Mol. Neurobiol. (IF 3.606) Pub Date : 2020-10-11 Kyrylo Fotesko, Bo Schneider Vohra Thomsen, Miriam Kolko, Rupali Vohra
Estrogen is essential in maintaining various physiological features in women, and a decline in estrogen levels are known to give rise to numerous unfortunate symptoms associated with menopause. To alleviate these symptoms hormone replacement therapy with estrogen is often used, and has been shown to be fruitful in improving quality of life in women suffering from postmenopausal discomforts. An often